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Fibrolamellar Hepatocellular Carcinoma and Noncirrhotic Hyperammonemic Encephalopathy

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Autores
Suarez, Oscar
Pérez, María
Garzón Olarte, Martín Alonso
Daza, Rodrigo
Hernandez, Geovanny
Salinas, Carolina
Ceballos, Jorge
De Leon, Enrique P.
Mugnier, Jacqueline
Beltrán, Oscar

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Fecha
2018-12-03

Directores
Garzón Olarte, Martín Alonso

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Editor
Universidad del Rosario

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Resumen
Abstract
Fibrolamellar hepatocarcinoma is an infrequent liver tumor, currently considered to be a variant different from hepatocarcinoma. The differences lie in genomic alterations, a greater prevalence of fibrolamellar hepatocarcinoma in young patients, and its lack of association with underlying liver disease. The clinical presentation is unspecific, with symptoms ranging from abdominal pain, malaise, and weight loss to atypical manifestation which include hyperammonemic encephalopathy. We present the case of a 33-year-old woman with no prior medical history who presented with a coma and a diagnosis of inoperable fibrolamellar hepatocarcinoma requiring a cadaver donor transplant. While she was on the waiting list, she received hemofiltration and ammonium benzoate treatment, with progressive improvement in her state of consciousness.
Palabras clave
Fibrolamellar hepatocellular carcinoma , Noncirrhotic hyperammonemic encephalopathy
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