dc.contributor.advisorLaissue, Paul 
dc.contributor.advisorFonseca-Mendoza, Dora Janeth 
dc.creatorFestiva Mora, María Camila 
dc.date.accessioned2017-04-03T18:11:01Z
dc.date.available2017-04-03T18:11:01Z
dc.date.created2017-03-03
dc.identifier.urihttp://repository.urosario.edu.co//handle/10336/13218
dc.descriptionLas proteínas ADAMTS (desintegrinas y metaloproteinasas con motivos trombospondina) han sido asociadas a diversos procesos biológicos entre ellos el desarrollo folicular y la ovulación. Algunos miembros son considerados proteínas huérfanas debido a que no se han descrito sus sustratos específicos (e.g. ADAMTS19). Específicamente ADAMTS19 ha sido sugerido recientemente como un gen candidato de FOP. En el presente trabajo se realizó un tamizaje de las potenciales proteínas de interacción (partners) de ADAMTS19 mediante el sistema de doble híbrido en levaduras. Se realizó coinmunoprecipitación en células transfectadas y en líquido folicular humano para verificar la interacción directa entre ADAMTS19 y COL6A2. Ensayos de RT-PCR efectuados para evaluar la coexpresión de Adamts19 y Col6a2 en ovarios de ratón. Adicionalmente, la técnica de inmunoflurescencia indirecta usó para evaluar la colocalización de las proteínas. Se encontró que ADAMTS19 se une directamente a COL6A2 en un contexto ovárico lo que se correlaciona con los hallazgos de coexpresión y de colocalización en líquido folicular humano. Proponemos que ADAMTS19 actúa sobre las microfibras de COL6A2 durante el crecimiento folicular y la expansión de la lámina basal. Encontramos que la mutación p.Thr943Ile ADAMTS19 identificada previamente en una paciente con FOP no alteraba la interacción ADAMTS19/COL6A2. Sin embargo, no descartamos que la mutación contribuya al fenotipo de FOP. Los resultados de este trabajo, que describen la primera proteína de interacción directa de ADAMTS19, arrojan nuevos datos sobre la función de las metaloproteinasas en la biología del ovario y la fertilidad.
dc.description.abstractADAMTS proteins (disintegrins and metalloproteinases with thrombospondin motifs) have been associated with various biological processes including follicular development and ovulation. Some members are considered orphan proteins because their specific substrates have not been described (e.g. ADAMTS19). Specifically ADAMTS19 has recently been suggested as a candidate gene for FOP. In the present study a screening of the potential interaction proteins (partners) of ADAMTS19 was carried out using yeast two hybrid assay. Co-immunoprecipitation was performed on transfected cells and human follicular fluid to verify the direct interaction between ADAMTS19 and COL6A2. RT-PCR assays werw performed to evaluate co-expression of Adamts19 and Col6a2 in mouse ovaries. In addition, the indirect immunofluorescence technique used to evaluate the colocalization of proteins. It was found that ADAMTS19 binds directly to COL6A2 in an ovarian context which correlates with the findings of coexpression and colocalization in human follicular fluid. We propose that ADAMTS19 acts on the microfibers of COL6A2 during follicular growth and expansion of the basal lamina. We found that the p.Thr943Ile ADAMTS19 mutation previously identified in a patient with FOP did not alter the ADAMTS19 / COL6A2 interaction. However, we do not rule out that the mutation contributes to the FOP phenotype. The results of this work, which describe the first direct interaction protein of ADAMTS19, yield new data on the role of metalloproteinases in ovarian biology and fertility.
dc.description.sponsorshipUniversidad del Rosario
dc.format.mimetypeapplication/pdf
dc.language.isospa
dc.sourcereponame:Repositorio Institucional EdocUR
dc.sourceinstname:Universidad del Rosario
dc.subjectADAMTS19
dc.subjectFalla ovárica prematura
dc.subjectOvario
dc.subjectInteracción proteica
dc.subjectCOL6A2
dc.subject.ddc575.1
dc.subject.lembGenética
dc.titleIdentificación de interacciones proteicas de ADAMTS19 en un contexto ovárico
dc.typemasterThesis
dc.publisherUniversidad del Rosario
dc.creator.degreeMagíster en Ciencias con Énfasis en Genética Humana
dc.publisher.programMaestría en Ciencias con Énfasis en Genética Humana
dc.publisher.departmentFacultad de medicina
dc.subject.keywordADAMTS19
dc.subject.keywordOvary
dc.subject.keywordProteic interaction
dc.subject.keywordPremature ovarian failure
dc.subject.keywordCOL6A2
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.subject.decsGenética
dc.subject.decsProcesos biológicos
dc.subject.decsEnfermedades del ovario
dc.type.spaTesis de maestría
dc.rights.accesoAbierto (Texto completo)
dc.type.hasVersioninfo:eu-repo/semantics/acceptedVersion
dc.source.bibliographicCitationAdriaenssens T, Mazoyer C, Segers I, Wathlet S, Smitz J, Blanche G. 2009. Differences in Collagen Expression in Cumulus Cells after Exposure to Highly Purified Menotropin or Recombinant Follicle-Stimulating Hormone in a Mouse Follicle Culture Model 1. Biol Reprod 1025:1015–1025.
dc.source.bibliographicCitationAittomäki K, Lucena JL, Pakarinen P, Sistonen P, Tapanainen J, Gromoll J, Kaskikari R, Sankila EM, Lehväslaiho H, Engel AR, Nieschlag E, Huhtaniemi I, et al. 1995. Mutation in the follicle-stimulating hormone receptor gene causes hereditary hypergonadotropic ovarian failure. Cell 82:959–68.
dc.source.bibliographicCitationAllen EG, Sullivan AK, Marcus M, Small C, Dominguez C, Epstein MP, Charen K, He W, Taylor KC, Sherman SL. 2007. Examination of reproductive aging milestones among women who carry the FMR1 premutation. Hum Reprod 22:2142–2152.
dc.source.bibliographicCitationAllen LA, Achermann JC, Pakarinen P, Kotlar TJ, Huhtaniemi IT, Jameson JL, Cheetham TD, Ball SG. 2003. A novel loss of function mutation in exon 10 of the FSH receptor gene causing hypergonadotrophic hypogonadism : clinical and molecular characteristics. Hum Reprod 18:251–256.
dc.source.bibliographicCitationAmato P, Roberts AC, D M. 2001. Transient ovarian failure : a complication of uterine artery embolization. Fertil Steril 75:438–439.
dc.source.bibliographicCitationAnders A, Gilbert S, Garten W, Postina R, Fahrenholz F. 2001. Regulation of the α -secretase ADAM10 by its prodomain and proprotein convertases. FASEB J 15:1837–1839.
dc.source.bibliographicCitationApte SS. 2009. A Disintegrin-like and Metalloprotease Thrombospondin Type 1 Motif ( ADAMTS ) Superfamily : Functions and Mechanisms *. J Biol Chem 284:31493–31497.
dc.source.bibliographicCitationAscoli M, Fanelli F, Segaloff DL. 2002. A 2002 Perspective. Endocr Rev 23:141–174.
dc.source.bibliographicCitationAten RF, Kolodecik TR, Macdonald GJ, Behrman HR. 1995. Modulation of Cholesteryl Ester Hydrolase Messenger Ribonucleic Acid Levels , Protein Levels , and Activity in the Rat Corpus Luteum ’. Biol Reprod 1117:1110–1117.
dc.source.bibliographicCitationAugustin HG, Braun K, Telemenakis I, Modlich U. 1995. Ovarian Angiogenesis Phenotypic Characterization of Endothelial Cells in a Physiological Model of Blood Vessel Growth and Regression. Am J Pathol 147:339–351.
dc.source.bibliographicCitationAyad S, Marriott a, Morgan K, Grant ME. 1989. Bovine cartilage types VI and IX collagens. Characterization of their forms in vivo. Biochem J 262:753–761.
dc.source.bibliographicCitationBadenas C, Quinto L, Puigoriol E, Tazo B, Rife M, Sa A, Mila M. 2004. Analysis of CGG variation through 642 meioses in Fragile X families. Mol Hum Reprod 10:773–776.
dc.source.bibliographicCitationBaere E De, Beysen D, Oley C, Lorenz B, Cocquet J, Sutter P De, Devriendt K, Dixon M, Fellous M, Fryns J-P, Garza A, Jonsrud C, et al. 2003. FOXL2 and BPES: mutational hotspots, phenotypic variability, and revision of the genotype-phenotype correlation. Am J Hum Genet 72:478–87.
dc.source.bibliographicCitationBaerwald AR, Adams GP, Pierson R a. 2012. Ovarian antral folliculogenesis during the human menstrual cycle: A review. Hum Reprod Update 18:73–91.
dc.source.bibliographicCitationBakalov VK, Anasti JN, Calis KA, Pharm D. 2005. Autoimmune oophoritis as a mechanism of follicular dysfunction in women with 46 , XX spontaneous premature ovarian failure. Fertil Steril 84:.
dc.source.bibliographicCitationBaker AH, Edwards DR, Murphy G. 2002. Metalloproteinase inhibitors: biological actions and therapeutic opportunities. J Cell Sci 115:3719–3727.
dc.source.bibliographicCitationBall AR, Chen Y, Yokomori K. 2014. Biochimica et Biophysica Acta Mechanisms of cohesin-mediated gene regulation and lessons learned from cohesinopathies ☆. BBA - Gene Regul Mech 1–12.
dc.source.bibliographicCitationBardhan A. 2010. Many functions of the meiotic cohesin Central element. Chromosom Res 18:909–924.
dc.source.bibliographicCitationBarlow C, Hirotsune S, Paylor R, Liyanage M, Eckhaus M, Collins F, Shiloh Y, Crawley JN, Ried T, Tagle D, Wynshaw-Boris A. 1996. Atm-deficient mice: a paradigm of ataxia telangiectasia. Cell 86:159–71.
dc.source.bibliographicCitationBarnett KR, Schilling C, Greenfeld CR, Tomic D, Flaws JA. 2006. Ovarian follicle development and transgenic mouse models. Hum Reprod Update 12:537–55.
dc.source.bibliographicCitationBayne RAL, Martins da Silva SJ, Anderson RA. 2004. Increased expression of the FIGLA transcription factor is associated with primordial follicle formation in the human fetal ovary. Mol Hum Reprod 10:373–81.
dc.source.bibliographicCitationBeau I, Touraine P, Meduri G, Gougeon A, Desroches A, Matuchansky C, Milgrom E, Kuttenn F, Misrahi M. 1998. A Novel Phenotype Related to Partial Loss of Function Mutations of the Follicle Stimulating Hormone Receptor. J Clin Invest 102:1352–1359.
dc.source.bibliographicCitationBedell MA, Brannan CI, Evans EP, Copeland NG, Jenkins NA, Donovan PJ. 1995. DNA rearrangements located over 100 kb 5’ of the Steel (Sl)-coding region in Steel-panda and Steel-contrasted mice deregulate Sl expression and cause female sterility by disrupting ovarian follicle development. Genes Dev 9:455–70.
dc.source.bibliographicCitationBell M V, Hirst MC, Nakahori Y, Jacobs PA, Tommerup N, Tranebjaerg L, Kerr B, Turner G, Lindenbaum RH, Thibodeau S. 1991. Physical Mapping across the Fragile X : Hypermethylation and Clinical Expression of the Fragile X Syndrome. Cell 64:861–866.
dc.source.bibliographicCitationBenayoun BA, Georges AB, L’Hôte D, Andersson N, Dipietromaria A, Todeschini A-L, Caburet S, Bazin C, Anttonen M, Veitia RA. 2011. Transcription factor FOXL2 protects granulosa cells from stress and delays cell cycle: role of its regulation by the SIRT1 deacetylase. Hum Mol Genet 20:1673–86.
dc.source.bibliographicCitationBevitt DJ, Li Z, Lindrop JL, Barker MD, Clarke MP, Mckie N. 2005. Analysis of full length ADAMTS6 transcript reveals alternative splicing and a role for the 5 V untranslated region in translational control B. Gene 359:99–110.
dc.source.bibliographicCitationBharath R, Unnikrishnan AG, Thampy M V, Anilkumar A, Nisha B, Praveen VP, Nair V, Jayakumar R V, Kumar H, Turner TA, Distribution SV-. 2010. Turner Syndrome and its Variants. 77:2008–2010.
dc.source.bibliographicCitationBouilly J, Bachelot A, Broutin I, Touraine P, Binart N. 2011. Novel NOBOX loss-of-function mutations account for 6.2% of cases in a large primary ovarian insufficiency cohort. Hum Mutat 32:1108–13.
dc.source.bibliographicCitationBouilly J, Roucher-Boulez Gompel, Bry-Gauillard F, Hélène A, Azibi K, Beldjord7 C, Dodé7 C, Bouligand1 J, Mantel1 AG, Hécart A-C, Delemer B, Young J, et al. 2015. New NOBOX Mutations identified in a Large Cohort decrease KIT-L Expression. J Clin Endocrinol Metab 10:1–9.
dc.source.bibliographicCitationBouma GJ, Albrecht KH, Washburn LL, Recknagel AK, Churchill GA, Eicher EM. 2005. Gonadal sex reversal in mutant Dax1 XY mice : a failure to upregulate Sox9 in pre-Sertoli cells. Development 132:3045–3054.
dc.source.bibliographicCitationBouma GJ, Hart GT, Washburn LL, Recknagel AK, Eicher EM. 2004. Using real time RT-PCR analysis to determine multiple gene expression patterns during XX and XY mouse fetal gonad development. Gene Expr Patterns 5:141–149.
dc.source.bibliographicCitationBrannstrom M, Woessner JF, Koos RD. 1988. Inhibitors of Mammalian Tissue Collagenase and Metalloproteinases Suppress Ovulation in the Perfused Rat Ovary *. Endocrinology 122:.
dc.source.bibliographicCitationBrocker CN, Vasiliou V, Nebert DW. 2009. Evolutionary divergence and functions of the ADAM and ADAMTS gene families. Hum Genomics 4:43–55.
dc.source.bibliographicCitationBrooks PC, Stro S, Sanders LC, Schalscha TL Von, Aimes RT, Stetler-stevenson WG, Quigley JP, Cheresh DA. 1996. Localization of Matrix Metalloproteinase MMP-2 to the Surface of Invasive Cells by Interaction with Integrin ␣ v ␤ 3. Cell 85:683–693.
dc.source.bibliographicCitationBruns R, Lu G, Pugsley T. 1986. Characterization of the A2 adenosine receptor labeled by [3H]NECA in rat striatal membranes. Mol Pharmacol 4:331–346.
dc.source.bibliographicCitationBurks DJ, Mora JF De, Schubert M, Withers DJ, Myers MG, Towery HH, Altamuro SL, Flint CL, White MF. 2000. IRS-2 pathways integrate female reproductionand energy homeostasis. 407:377–382.
dc.source.bibliographicCitationCaburet S, Arboleda VA, Llano E, Overbeek PA, Barbero JL, Oka K, Harrison I, Vaiman D, Ben-Neriah Z, García-Tuñón I, Fellous M, Pendás AM, et al. 2014. Mutant Cohesin in Premature Ovarian Failure. N Engl J Med 10:943–949.
dc.source.bibliographicCitationCaburet S, Zavadakova P, Ben-Neriah Z, Bouhali K, Dipietromaria A, Charon C, Besse C, Laissue P, Chalifa-Caspi V, Christin-Maitre S, Vaiman D, Levi G, et al. 2012. Genome-Wide Linkage in a Highly Consanguineous Pedigree Reveals Two Novel Loci on Chromosome 7 for Non-Syndromic Familial Premature Ovarian Failure. PLoS One 7:1–6.
dc.source.bibliographicCitationCal S, Obaya AJ, Llamazares M, Garabaya C, Quesada V, Carlos Lopez-Otin. 2002. Cloning , expression analysis , and structural characterization of seven novel human ADAMTSs , a family of metalloproteinases with disintegrin and thrombospondin-1 domains. Gene 283:49–62.
dc.source.bibliographicCitationCarre G, Couty I, Hennequet-antier C, Govoroun MS. 2011. Gene Expression Profiling Reveals New Potential Players of Gonad Differentiation in the Chicken Embryo. PLoS One 6:1–12.
dc.source.bibliographicCitationChang H, Brown CW, Matzuk MM. 2002. Genetic analysis of the mammalian transforming growth factor-beta superfamily. Endocr Rev 23:787–823.
dc.source.bibliographicCitationChoi J, Smitz J. 2014. Molecular and Cellular Endocrinology Luteinizing hormone and human chorionic gonadotropin : Origins of difference. Mol Cell Endocrinol 383:203–213.
dc.source.bibliographicCitationChoi Y, Rajkovic A. 2006. Characterization of NOBOX DNA binding specificity and its regulation of Gdf9 and Pou5f1 promoters. J Biol Chem 281:35747–56.
dc.source.bibliographicCitationChristin-Maitre S, Vasseur C, Portnoı̈ M-F, Bouchard P. 1998. Genes and premature ovarian failure. Mol Cell Endocrinol 145:75–80.
dc.source.bibliographicCitationChun SY, Eisenhauer KM, Minami S, Billig H, Perlas E, Hsueh AJ. 1996. Hormonal regulation of apoptosis in early antral follicles: follicle-stimulating hormone as a major survival factor. Endocrinology 137:1447–56.
dc.source.bibliographicCitationConnell MRO, Roland Gamsjaeger, Mackay JP. 2009. The structural analysis of protein – protein interactions by NMR spectroscopy. Proteomics 9:5224–5232.
dc.source.bibliographicCitationConway GS. 2000. Premature ovarian failure. Br Med Bull 56:643–649.
dc.source.bibliographicCitationCordts EB, Christofolini DM, Santos AA Dos, Bianco B, Barbosa CP. 2011. Genetic aspects of premature ovarian failure: A literature review. Arch Gynecol Obstet 283:635–643.
dc.source.bibliographicCitationCorrea SM, Washburn LL, Kahlon RS, Musson MC, Bouma GJ, Eicher EM, Albrecht KH. 2012. Sex reversal in C57BL/6J XY mice caused by increased expression of ovarian genes and insufficient activation of the testis determining pathway. PLoS Genet 8:.
dc.source.bibliographicCitationCoulam CB, Adamson SC, Annegers JF. 1986. Incidence of premature ovarian failure. Obstet Gynecol 67:604–6.
dc.source.bibliographicCitationCrisponi L, Deiana M, Loi A, Chiappe F, Uda M, Amati P, Bisceglia L, Zelante L, Nagaraja R, Porcu S, Ristaldi MS, Marzella R, et al. 2001. The putative forkhead transcription factor FOXL2 is mutated in blepharophimosis/ptosis/epicanthus inversus syndrome. Nat Genet 27:159–66.
dc.source.bibliographicCitationCurry TE, Osteen KG. 2001. Cyclic changes in the matrix metalloproteinase system in the ovary and uterus. Biol Reprod 64:1285–1296.
dc.source.bibliographicCitationDaley WP, Peters SB, Larsen M. 2008. Extracellular matrix dynamics in development and regenerative medicine. J Cell Sci 121:255–64.
dc.source.bibliographicCitationDavid Vantman B, Margarita Vega B. 2010. Fisiología reproductiva y cambios evolutivos con la edad de la mujer. Rev Médica Clínica Las Condes 21:348–362.
dc.source.bibliographicCitationDavies J a. 2001. Extracellular Matrix. Encycl Life Sci 1–7.
dc.source.bibliographicCitationDiaz FJ, Wigglesworth K, Eppig JJ. 2007. Oocytes determine cumulus cell lineage in mouse ovarian follicles. 1330–1340.
dc.source.bibliographicCitationDijke P, Arthur HM. 2007. Extracellular control of TGF β signalling in vascular development and disease. Nat Rev Mol Cell Biol 8:857–869.
dc.source.bibliographicCitationDoherty E, Pakarinen P, Tiitinen A, Kiilavuori A, Huhtaniemi I, Forrest S, Aittoma K. 2002. A Novel Mutation in the FSH Receptor Inhibiting Signal Transduction and Causing Primary Ovarian Failure. J Clin Endocrinol Metab 87:1151–1155.
dc.source.bibliographicCitationDoyle KMH, Russell DL, Sriraman V, Richards JS. 2015. Coordinate Transcription of the ADAMTS-1 Gene by Luteinizing Hormone and Progesterone Receptor. Mol Endocrinol 18(10)2463–2478 18:2463–2478.
dc.source.bibliographicCitationDroesch K, Navot D, Scott R, Kreiner D, Liu H, Rosenwaks Z. 1988. Transdermal estrogen replacement in ovarian failure for ovum donation. Fertil Steril 259:1353–1356.
dc.source.bibliographicCitationDube JL, Wang P, Elvin J, Lyons KM, Celeste AJ, Matzuk MM. 1998. The bone morphogenetic protein 15 gene is X-linked and expressed in oocytes. Mol Endocrinol 12:1809–17.
dc.source.bibliographicCitationDube JL, Wang P, Elvin J, Lyons KM, Celeste AJ, Matzuk MM. 2016. The Bone Morphogenetic Protein 15 Gene Is X-Linked and Expressed in Oocytes. Mol Endocrinol 12:1809–1817.
dc.source.bibliographicCitationEdson M a., Nagaraja AK, Matzuk MM. 2009. The mammalian ovary from genesis to revelation. Endocr Rev 30:624–712.
dc.source.bibliographicCitationEdwards DR, Handsley MM, Pennington CJ. 2009. The ADAM metalloproteinases. Mol Aspects Med 29:258–289.
dc.source.bibliographicCitationEgeblad M, Rasch MG, Weaver VM. 2010. Dynamic interplay between the collagen scaffold and tumor evolution. Curr Opin Cell Biol 22:697–706.
dc.source.bibliographicCitationElsheikh M, Dunger DB, Conway GS, Wass JAH, Infirmary R, Kingdom U. 2015. Turner ’ s Syndrome in Adulthood. Endocr Rev 23:120–140.
dc.source.bibliographicCitationElvin JA, Yan C, Wang P, Nishimori K, Matzuk MM. 1999. Molecular characterization of the follicle defects in the growth differentiation factor 9-deficient ovary. Mol Endocrinol 13:1018–34.
dc.source.bibliographicCitationErickson GF, Shimasaki S. 2003. The spatiotemporal expression pattern of the bone morphogenetic protein family in rat ovary cell types during the estrous cycle. Reprod Biol Endocrinol 20:1–20.
dc.source.bibliographicCitationEspey LL, Yoshioka S, Russell DL, Robker RL, Fujii S, Richards JS. 2000. Ovarian Expression of a Disintegrin and Metalloproteinase with Thrombospondin Motifs During Ovulation in the Gonadotropin-Primed Immature Rat 1. Biol Reprod 1095:1090–1095.
dc.source.bibliographicCitationFarin CE, Moeller CL, Sawyer HR, Niswender GD. 1986. Morphometric Analysis of Cell Types in the Ovine throughout the Estrous Cycle ’ Corpus Luteum. Biol Reprod 35:1299–1308.
dc.source.bibliographicCitationFechner PY, Davenport ML, Qualy RL, Ross JL, Gunther DF, Eugster EA, Huseman C, Zagar AJ, Quigley CA. 2006. Differences in Follicle-Stimulating Hormone Secretion between 45 , X Monosomy Turner Syndrome and and 45, X/46, XX mosaicism are evident at an early age. J Clin Endocrinol Metab 91:4896–4902.
dc.source.bibliographicCitationFernandes RJ, Hirohata S, Engle JM, Colige A, Cohn DH, Eyre DR, Apte SS. 2001. Procollagen II Amino Propeptide Processing by ADAMTS-3. Biochem Mol Biol 276:31502–31509.
dc.source.bibliographicCitationFields S, Song O. 1989. A novel genetic system to detect protein-protein interactions. Nature 245–246.
dc.source.bibliographicCitationFlannery CR, Zeng W, Corcoran C, Collins-racie LA, Chockalingam PS, Hebert T, Mackie SA, Mcdonagh T, Crawford TK, Tomkinson KN, Lavallie ER, Morris EA, et al. 2002. Autocatalytic Cleavage of ADAMTS-4 ( Aggrecanase-1 ) Reveals Multiple Glycosaminoglycan-binding Sites *. J Biol Chem 277:42775–42780.
dc.source.bibliographicCitationFolgueras AR, Pendás AM, Sánchez LM, López-otín C. 2004. Matrix metalloproteinases in cancer : from new functions to improved inhibition strategies. Int J Dev Biol 48:411–424.
dc.source.bibliographicCitationFonseca DJ, Patiño LC, Suárez Y, Rodríguez A, Mateus H, Jiménez KM, O O-R, Díaz-Yamal I, Laissue P. 2015. Next generation sequencing in women affected by nonsyndromic premature ovarian failure displays new potential causative genes and mutations. Fertil Steril 104:154–62.
dc.source.bibliographicCitationFortune JE, Willis EL, Bridges PJ, Yang CS. 2010. The periovulatory period in cattle: progesterone, prostaglandins, oxytocin and ADAMTS proteases. Anim Reprod 6:60–71.
dc.source.bibliographicCitationFreimann S, Ben-Ami I, Dantes A, Armon L, YaÕcov-Klein A Ben, Ron-El R, Amsterdam A. 2005. Differential expression of genes coding for EGF-like factors and ADAMTS1 following gonadotropin stimulation in normal and transformed human granulosa cells. Biochem Biophys Res Commun 333:935–943.
dc.source.bibliographicCitationFriedl P, Gilmour D. 2009. Collective cell migration in morphogenesis, regeneration and cancer. Nat Rev Mol Cell Biol 10:445–457.
dc.source.bibliographicCitationG. Meduri P, Touraine I, Beau O, Lahuna A, Desroches M, Vacher-lavenuF. C, Kuttenn, Misrahi. 2003. Delayed Puberty and Primary Amenorrhea Associated with a Novel Mutation of the Human Follicle-Stimulating Hormone Receptor : Clinical , Histological , and Molecular Studies. J Clin Endocrinol Metab 88:3491–3498.
dc.source.bibliographicCitationGao G, Plaas A, Thompson VP, Jin S, Zuo F, Sandy JD, Gao G, Plaas A, Thompson VP, Jin S, Zuo F, Sandy JD. 2004. Glycobiology and Extracellular Matrices : the Cell Surface Involves C-terminal Cleavage by Glycosylphosphatidyl Inositol-anchored Membrane Type 4-Matrix Metalloproteinase and Binding of the Activated Proteinase to Chondroitin Sulfate and Heparan Sulfate o. J Biol Chem 279:10042–10051.
dc.source.bibliographicCitationGao S, Geyter C De, Kossowska K, Zhang H. 2007. FSH stimulates the expression of the ADAMTS-16 protease in mature human ovarian follicles. Mol Hum Reprod 13:465–71.
dc.source.bibliographicCitationGarcia-Cruz1 R, Brienño MA, Roig I, Grossmann M, Velilla E, Brien MA, Pujol A, Cabero L, Pessarrodona A, Barbero JL. 2010. Dynamics of cohesin proteins REC8 , STAG3 , SMC1 b and SMC3 are consistent with a role in sister chromatid cohesion during meiosis in human oocytes. 25:2316–2327.
dc.source.bibliographicCitationGelse K, Po E, Aigner T. 2003. Collagens — structure , function , and biosynthesis. Adv Drug Deliv Rev 55:1531–1546.
dc.source.bibliographicCitationGoor H van, Melenhorst WB, Turner AJ, Holgate ST. 2010. Adamalysins in biology and disease. J Pathol 220:114–125.
dc.source.bibliographicCitationGoswami D, Conway GS. 2005. Premature ovarian failure. Hum Reprod Update 11:391–410.
dc.source.bibliographicCitationGuo F, Lai Y, Tian Q, Lin EA, Kong L, Liu C. 2010. Granulin-Epithelin Precursor Binds Directly to ADAMTS-7 and ADAMTS-12 and Inhibits Their Degradation of Cartilage Oligomeric Matrix Protein. Arthritis Rheum 62:2023–2036.
dc.source.bibliographicCitationHagglund A-C, Basset P, Ny T. 2001. Stromelysin-3 Is Induced in Mouse Ovarian Follicles Undergoing Hormonally Controlled Apoptosis , but This Metalloproteinase Is Not Required for Follicular Atresia 1. Biol Reprod 463:457–463.
dc.source.bibliographicCitationHagglund A-C, Leonardsson AN, Goran Ny T or. 1999. Regulation and Localization of Matrix Metalloproteinases and Tissue Inhibitors of Metalloproteinases in the Mouse Ovary during. Society 140:.
dc.source.bibliographicCitationHannenhalli S, Kaestner KH. 2009. The evolution of Fox genes and their role in development and disease. Nat Rev Genet 10:233–40.
dc.source.bibliographicCitationHarris SE, Chand AL, Winship IM, Gersak K, Aittomäki K, Shelling AN. 2002. Identification of novel mutations in FOXL2 associated with premature ovarian failure. Mol Hum Reprod 8:729–33.
dc.source.bibliographicCitationHashimoto O, Moore RK, Shimasaki S. 2005. Posttranslational processing of mouse and human BMP-15 : Potential implication in the determination of ovulation quota.
dc.source.bibliographicCitationHashimotoa Yb G, Aokic T, Nakamuraa H, Tanzawad K, Yasunori Okadaa. 2001. Inhibition of ADAMTS4 ( aggrecanase-1 ) by tissue inhibitors of metalloproteinases (TIMP-1, 2, 3 and 4). FEBS Lett 494:192–195.
dc.source.bibliographicCitationHinsbergh VWM Van, Koolwijk P. 2008. Endothelial sprouting and angiogenesis : matrix metalloproteinases in the lead. Cardiovasc Res 78:203–212.
dc.source.bibliographicCitationHirshfield AN. 1991. Development of follicles in the mammalian ovary. Int Rev Cytol 124:43–101.
dc.source.bibliographicCitationHo Y, Gargano M, Cao J, Bronson RT, Heimler I, Hutz RJ, Ho Y, Gargano M, Cao J, Bronson RT, Heimler I, Hutz RJ. 1998. NUCLEIC ACIDS , PROTEIN SYNTHESIS , AND MOLECULAR GENETICS : Reduced Fertility in Female Mice Lacking Reduced Fertility in Female Mice Lacking Copper-Zinc Superoxide Dismutase *. Biol Chem 273:7765–7769.
dc.source.bibliographicCitationHoumard B, Small C, Yang L, Naluai-cecchini T, Cheng E, Hassold T, Griswold M. 2009. Global Gene Expression in the Human Fetal Testis and Ovary 1. Biol Reprod 443:438–443.
dc.source.bibliographicCitationHowell S, Shalet S. 1998. Gonadal Damage From Chemotherapy And Radiotherapy. Gonadal Disord 27:927–943.
dc.source.bibliographicCitationHuet C, Monget P, Pisselet C, Monniaux D. 1997. Changes in extracellular matrix components and steroidogenic enzymes during growth and atresia of antral ovarian follicles in the sheep. Biol Reprod 56:1025–34.
dc.source.bibliographicCitationHuntriss J, Gosden R, Hinkins M, Oliver B, Miller D, Rutherford AJ, Picton HM. 2002. Isolation , characterization and expression of the human Factor In the Germline alpha ( FIGLA ) gene in ovarian follicles and oocytes. Mol Hum Reprod 8:1087–1095.
dc.source.bibliographicCitationHutt KJ, Albertini DF. 2007. An oocentric view of folliculogenesis and embryogenesis. Reprod Biomed Online 14:758–764.
dc.source.bibliographicCitationHynes RO. 2009. The Extracellular Matrix: Not Just Pretty Fibrils. Relat Res Sci (New York, NY) 326:2009.
dc.source.bibliographicCitationIruela-arispe ML, Lombardo M, Krutzsch HC, Lawler J, Roberts DD. 1999. Inhibition of Angiogenesis by Thrombospondin-1 Is Mediated by 2 Independent Regions Within the Type 1 Repeats. Circulation 100:1423–1431.
dc.source.bibliographicCitationIrving-Rodgers HF, Friden BE, Morris SE, Mason HD, Brannstrom M, Sekiguchi K, Sanzen N, Sorokin LM, Sado Y, Ninomiya Y, Rodgers RJ. 2006. Extracellular matrix of the human cyclic corpus luteum. Mol Hum Reprod 12:525–534.
dc.source.bibliographicCitationIrving-Rodgers HF, Harland ML, Rodgers RJ. 2004. A novel basal lamina matrix of the stratified epithelium of the ovarian follicle. Matrix Biol 23:207–217.
dc.source.bibliographicCitationIwahashi M, Muragaki Y, Ooshima A, Nakano R. 2000. Type VI collagen expression during growth of human ovarian follicles. Fertil Steril 74:343–347.
dc.source.bibliographicCitationJacobi CLJ, Rudigier LJ, Scholz H, Kirschner KM. 2013. Developmental Biology : Transcriptional regulation by the Wilms tumor protein , Wt1 , suggests a role of the metalloproteinase Adamts16 in murine genitourinary development. J Biol Chem 288:0–27.
dc.source.bibliographicCitationJiao X, Qin Y, Li G, Zhao S, You L, Ma J, Simpson JL, Chen Z-J. 2015. Novel NR5A1 missense mutation in premature ovarian failure: detection in han chinese indicates causation in different ethnic groups. PLoS One 8:e74759.
dc.source.bibliographicCitationJin P, Warren ST. 2000. Understanding the molecular basis of fragile X syndrome. Hum Mol Genet 9:901–908.
dc.source.bibliographicCitationJirawatnotai S, Moons DS, Stocco CO, Franks R, Hales DB, Gibori G, Kiyokawa H. 2003. The cyclin-dependent kinase inhibitors p27Kip1 and p21Cip1 cooperate to restrict proliferative life span in differentiating ovarian cells. J Biol Chem 278:17021–7.
dc.source.bibliographicCitationJones GC, Riley GP. 2005. Review ADAMTS proteinases : a multi-domain , multi-functional family with roles in extracellular matrix turnover and arthritis. Arthritis Res Ther 7:160–169.
dc.source.bibliographicCitationJoshi S, Davies H, Sims LP, Levy SE, Dean J. 2007. Ovarian gene expression in the absence of FIGLA, an oocyte-specific transcription factor. BMC Dev Biol 7:67.
dc.source.bibliographicCitationJr CTA, Wilkinson KD, Reines D, Warren ST. 1993. FMR1 Protein : Conserved RNP Family Domains and Selective RNA Binding. Science (80- ) 939:.
dc.source.bibliographicCitationJuenguel JL, Garverick HA, Johnson AL, Youngquist RS, Smith F. 1993. Apoptosis during Luteal Regression. Endocrinology 132:2–7.
dc.source.bibliographicCitationKaboord B, Perr M. 2008. Isolation of proteins and protein complexes by immunoprecipitation. Methods Mol Biol 424:349–364.
dc.source.bibliographicCitationKashiwagi M, Tortorella M, Nagase H, Brew K. 2001. TIMP-3 Is a Potent Inhibitor of Adam-ts aggrecanase. J Biol Chem 1:12501–12505.
dc.source.bibliographicCitationKelwick R, Desanlis I, Wheeler GN, Edwards DR. 2015. The ADAMTS ( A Disintegrin and Metalloproteinase with Thrombospondin motifs ) family. Genome Biol 16:113.
dc.source.bibliographicCitationKevorkian L, Young DA, Darrah C, Donell ST, Shepstone L, Porter S, Brockbank SM V, Edwards DR, Parker AE, Clark IM. 2004. Expression Profiling of Metalloproteinases and Their Inhibitors in Cartilage. Arthritis Rheum 50:131–141.
dc.source.bibliographicCitationKhole V. 2010. Does ovarian autoimmunity play a role in the pathophysiology of premature ovarian insufficiency? J Midlife Health 1:9–13.
dc.source.bibliographicCitationKim JY. 2012. Control of ovarian primordial follicle activation. Clin Exp Reprod Med 39:10–14.
dc.source.bibliographicCitationKnauff E a H, Franke L, Es M a van, Berg LH van den, Schouw YT van der, Laven JSE, Lambalk CB, Hoek A, Goverde AJ, Christin-Maitre S, Hsueh AJ, Wijmenga C, et al. 2009a. Genome-wide association study in premature ovarian failure patients suggests ADAMTS19 as a possible candidate gene. Hum Reprod 24:2372–2378.
dc.source.bibliographicCitationKnauff EAH, Franke L, Es MA Van, Berg LH Van Den, Schouw YT Van Der, Laven JSE, Lambalk CB, Hoek A, Goverde AJ, Christin-maitre S, Hsueh AJ, Wijmenga C, et al. 2009b. Genome-wide association study in premature ovarian failure patients suggests ADAMTS19 as a possible candidate gene. Hum Reprod 24:2372–2378.
dc.source.bibliographicCitationKokcu A, Yavuz E, Celik H, Bildircin D. 2012. A panoramic view to relationships between reproductive failure and immunological factors. Arch Gynecol Obstet 286:1283–9.
dc.source.bibliographicCitationKozak M. 2002. Emerging links between initiation of translation and human diseases. Mamm Genome 410:.
dc.source.bibliographicCitationKrege JH, HODGIN JB, COUSE JF, ENMARK E, WARNER M, MAHLER JF, SAR M, KORACH KS, GUSTAFSSON J-A, SMITHIES O. 1998. Generation and reproductive phenotypes of mice lacking estrogen receptor ␤. Med Sci 95:15677–15682.
dc.source.bibliographicCitationKuechler A, Kleinau G, Albrecht B, Hauffa BP, Ko A, Horsthemke B. 2010. An unbalanced translocation unmasks a recessive mutation in the follicle-stimulating hormone receptor ( FSHR ) gene and causes FSH resistance. Eur J Hum Genet 656–661.
dc.source.bibliographicCitationKuno K, Matsushima K. 1998. ADAMTS-1 protein anchors at the extracellular matrix through the thrombospondin type I motifs and its spacing region. J Biol Chem 273:13912–13917.
dc.source.bibliographicCitationLaissue P. 2015. Aetiological coding sequence variants in non-syndromic premature ovarian failure : From genetic linkage analysis to next generation sequencing. Mol Cell Endocrinol 411:243–257.
dc.source.bibliographicCitationLaissue P, Christin-maitre S, Touraine P, Kuttenn F, Ritvos O, Aittomaki K, Bourcigaux N, Jacquesson L, Bouchard P, Frydman R, Dewailly D, Jeffery L, et al. 2006. Mutations and sequence variants in GDF9 and BMP15 in patients with premature ovarian failure. Eur J Endocrinol 154:22–24.
dc.source.bibliographicCitationLaissue P, Lakhal B, Benayoun BA, Dipietromaria A, Braham R, Elghezal H, Philibert P, Saâd A, Sultan C, Fellous M, Veitia RA. 2009. Functional evidence implicating FOXL2 in non-syndromic premature ovarian failure and in the regulation of the transcription factor OSR2. J Med Genet 46:455–7.
dc.source.bibliographicCitationLaissue P, Vinci G, Veitia RA, Fellous M. 2008. Recent advances in the study of genes involved in non-syndromic premature ovarian failure. Mol Cell Endocrinol 282:101–111.
dc.source.bibliographicCitationLalli E, Doghman M, Late PL De, Wakil A El, Mus-veteau I. 2013. Molecular and Cellular Endocrinology Beyond steroidogenesis : Novel target genes for SF-1 discovered by genomics. Mol Cell Endocrinol 371:154–159.
dc.source.bibliographicCitationLampe A, Flanigan K, Bushby K, Hicks D. 2012. Genetics Home Reference. J Med Libr Assoc 92:282–283.
dc.source.bibliographicCitationLarsen M, Wei C, Yamada KM. 2006. Cell and fibronectin dynamics during branching morphogenesis. J Cell Sci 119:3376–84.
dc.source.bibliographicCitationLatronico AC, Anasti J, Arnhold IJ, Rapaport R, Mendonca BB, Bloise W, Castro M, Tsigos C, Chrousos GP. 1996. Brief report: testicular and ovarian resistance to luteinizing hormone caused by inactivating mutations of the luteinizing hormone-receptor gene. N Engl J Med 334:507–12.
dc.source.bibliographicCitationLatronico AC, Chai Y, Arnhold IJP, Liu X, Mendonca BB, Segaloff DL. 1998. A Homozygous Microdeletion in Helix 7 of the Luteinizing Hormone Receptor Associated with Familial Testicular and Ovarian Resistance Is Due to Both Decreased Cell Surface Expression and Impaired Effector Activation by the Cell Surface Receptor. 442–450.
dc.source.bibliographicCitationLehmann OJ, Sowden JC, Carlsson P, Jordan T, Bhattacharya SS. 2003. Fox’s in development and disease. Trends Genet 19:339–44.
dc.source.bibliographicCitationLi Q, Rajanahally S, Edson M a, Matzuk MM. 2009. Stable expression and characterization of N-terminal tagged recombinant human bone morphogenetic protein 15. Mol Hum Reprod 15:779–88.
dc.source.bibliographicCitationLi SW, Arita M, Fertala A, Bao Y, Kopen GC, Långsjö TK, Hyttinen MM, Helminen HJ, Prockop DJ. 2001. Transgenic mice with inactive alleles for procollagen N-proteinase (ADAMTS-2) develop fragile skin and male sterility. Biochem J 355:271–8.
dc.source.bibliographicCitationLiang L, Soyal SM, Dean J. 1997. FIGalpha, a germ cell specific transcription factor involved in the coordinate expression of the zona pellucida genes. Development 124:4939–47.
dc.source.bibliographicCitationLin L, Achermann JC. 2008. Steroidogenic factor-1 (SF-1, Ad4BP, NR5A1) and disorders of testis development. Sex Dev 2:200–9.
dc.source.bibliographicCitationLiu K, Olofsson JI, Wahlberg P, Ny T. 1999. Distinct expression of gelatinase A [matrix metalloproteinase (MMP)-2], collagenase-3 (MMP-13), membrane type MMP 1 (MMP-14), and tissue inhibitor of MMPs type 1 mediated by physiological signals during formation and regression of the rat corpus luteum. Endocrinology 140:5330–5338.
dc.source.bibliographicCitationLoesch DZ, Bui QM, Huggins RM, Mitchell RJ, Hagerman RJ. 2007. Transcript levels of the intermediate size or grey zone fragile X mental retardation 1 alleles are raised, and correlate with the number of CGG repeats. J med Genet 44:200–205.
dc.source.bibliographicCitationLourenço D, Brauner R, Lin L, Perdigo A De, Weryha G, Muresan M, Boudjenah R, Guerra-Junior G, Maciel-Guerra AT, Achermann JC, McElreavey K, Bashamboo A. 2009. Mutations in NR5A1 associated with ovarian insufficiency. N Engl J Med 360:1200–10.
dc.source.bibliographicCitationLu B, Poirier C, Gaspar T, Gratzke C, Harrison W, Busija D, Matzuk MM, Andersson K, Overbeek PA, Bishop CE, Al LUET. 2008. A Mutation in the Inner Mitochondrial Membrane Peptidase 2-Like Gene ( Immp2l ) Affects Mitochondrial Function and Impairs Fertility in Mice 1. Biol Reprod 610:601–610.
dc.source.bibliographicCitationLu P, Takai K, Weaver VM, Werb Z. 2011a. Extracellular Matrix degradation and remodeling in development and disease. Cold Spring Harb Perspect Biol 3:.
dc.source.bibliographicCitationLu P, Takai K, Weaver VM, Werb Z, Lu P, Takai K, Weaver VM, Hynes RO, Naba A, Huttenlocher A, Horwitz AR, Geiger B, et al. 2011b. Extracellular Matrix Degradation and Remodeling. Cold Spring Harb Perspect Biol 3:.
dc.source.bibliographicCitationLubahn DB, Moyer JS, Thomas S, Couse JF. 1993. Alteration of reproductive function but not prenatal sexual development after insertional disruption of the mouse estrogen receptor gene. Genetics 90:11162–11166.
dc.source.bibliographicCitationLuo X, Ikeda Y, Parker KL. 1994. A cell-specific nuclear receptor is essential for adrenal and gonadal development and sexual differentiation. Cell 77:481–90.
dc.source.bibliographicCitationMaclaran K, Horner E, Panay N. 2010. Premature ovarian failure : long-term sequelae. Menopause Int 16:38–41.
dc.source.bibliographicCitationMaclaran K, Panay N. 2011. Premature ovarian failure. 35–42.
dc.source.bibliographicCitationMagoffin DA. 2005. Ovarian theca cell. Biochem cell Biol 37:1344–1349.
dc.source.bibliographicCitationManzaneque JCR, Milchanowski AB, Erick K. Dufour R, Iruela-Arispe L a, Luisa M. 2000. Post-Translation Modification And Degradation : Forms Characterization of METH-1 / ADAMTS1 Processing Reveals Two Distinct Active Forms. J Biol Chem 275:33471–33479.
dc.source.bibliographicCitationMaraldi NM, Sabatelli P, Columbaro M, Zamparelli A, Manzoli FA, Bernardi P, Bonaldo P, Merlini L. 2009. Advances in Enzyme Regulation Collagen VI myopathies : From the animal model to the clinical trial. Adv Enzyme Regul 49:197–211.
dc.source.bibliographicCitationMassagué J, Seoane J, Wotton D. 2005. Smad transcription factors. Genes Dev 19:2783–2810.
dc.source.bibliographicCitationMatzuk MM. 1998. Printed in U.S.A. 4008. 139:4008–4011.
dc.source.bibliographicCitationMcClelland KS, Wainwright EN, Bowles J, Koopman P. 2015. Rapid screening of gene function by systemic delivery of morpholino oligonucleotides to live mouse embryos. PLoS One 10:e0114932.
dc.source.bibliographicCitationMcculloch DR, Nelson CM, Dixon LJ, Silver DL, Wylie JD, Lindner V, Sasaki T, Cooley MA, Argraves WS, Apte SS. 2009. Article ADAMTS Metalloproteases Generate Active Versican Fragments that Regulate Interdigital Web Regression. Dev Cell 17:687–698.
dc.source.bibliographicCitationMehta GD, Kumar R, Srivastava S, Ghosh SK. 2013. Cohesin : Functions beyond sister chromatid cohesion. FEBS Lett 587:2299–2312.
dc.source.bibliographicCitationMenke DB, Koubova J, Page DC. 2003. Sexual differentiation of germ cells in XX mouse gonads occurs in an anterior-to-posterior wave. Dev Biol 262:303–312.
dc.source.bibliographicCitationMenke DB, Page DC. 2002. Sexually dimorphic gene expression in the developing mouse gonad. Gene Expr Patterns 2:359–367.
dc.source.bibliographicCitationMittaz L, Russell DL, Wilson T, Brasted M, Tkalcevic J, Salamonsen LA, Hertzog PJ, Pritchard MA. 2004. Adamts-1 is essential for the development and function of the urogenital system. Biol Reprod 70:1096–105.
dc.source.bibliographicCitationMochizuki S, Okada Y. 2007. ADAMs in cancer cell proliferation and progression. Cancer Sci 98:621–628.
dc.source.bibliographicCitationMott JD, Werb Z. 2004. Regulation of matrix biology by matrix metalloproteinases.
dc.source.bibliographicCitationN. Camats A, Pandey M V., Fernandez-cancio P, Andaluz M, Janner N, Tora´ n F, Moreno A, Bereket T, Akcay E, García-garcía M, Oz TM, R. Gracia M, et al. 2012. Ten Novel Mutations in the NR5A1 Gene Cause Disordered Sex Development in 46 , XY and Ovarian Insufficiency in 46 , XX Individuals. J Clin Endocrinol Metab 97:1294–1306.
dc.source.bibliographicCitationNelson RM, Long GL. 1991. Solution-Phase Equilibrium Binding Interaction. Biochemestry 30:2384–2390.
dc.source.bibliographicCitationNett TM, McClellan MC, Niswender GD. 1976. Effects of Prostaglandins Flow , Secretion on the Ovine of Progesterone Corpus Luteum : and Morphology ’ of intact. Biol Reprod 66–78.
dc.source.bibliographicCitationNicholson AC, Malik S-B, Logsdon JM, Meir EG Van. 2005. Functional evolution of ADAMTS genes: evidence from analyses of phylogeny and gene organization. BMC Evol Biol 5:11.
dc.source.bibliographicCitationNusgens B, Verellen-Dumoulin C, Hermanns-Lê T, Paepe A De, Nuytinck L, Piérard G, Lapière C. 1992. Evidence for a relationship between Ehlers-Danlos type VII C in humans and bovine dermatosparaxis. Nat Genet 1:214–217.
dc.source.bibliographicCitationNy. T, Peng X-R, Ohlsson M. 1993. of Cell and Molecular Biology, University. Thromb Res 1:3848.
dc.source.bibliographicCitationNy T, Wahlberg P, Brändström IJM. 2002. Matrix remodeling in the ovary: Regulation and functional role of the plasminogen activator and matrix metalloproteinase systems. Mol Cell Endocrinol 187:29–38.
dc.source.bibliographicCitationOjeda D, Lakhal B, Fonseca DJ, Braham R, Landolsi H, Mateus HE, Restrepo CM, Elghezal H, Saâd A, Laissue P. 2011. Sequence analysis of the CDKN1B gene in patients with premature ovarian failure reveals a novel mutation potentially related to the phenotype. Fertil Steril 95:2658–2661.
dc.source.bibliographicCitationOtsuka F, Yao Z, Lee T, Yamamoto S, Erickson GF, Shimasaki S. 2000. Bone morphogenetic protein-15. Identification of target cells and biological functions. J Biol Chem 275:39523–8.
dc.source.bibliographicCitationOtte A, Roy D, Siemerink M, Koster C, Hochstenbach F, Timmermans A, J A. 1990. Characterization of a Maternal Type VI Collagen in. J Cell Biol 111:271–278.
dc.source.bibliographicCitationOverall CM, Lopez-Otin C. 2002. Strategies for MMP inhibition in cancer: innovations for the post-trial era. Nat Rev Cancer 2:657–672.
dc.source.bibliographicCitationPapers JBC, Doi M, Russell DL, Doyle KMH, Ochsner SA, Sandy JD, Richards JS. 2003. Processing and Localization of ADAMTS-1 and Proteolytic Cleavage of Versican during Cumulus Matrix Expansion and Ovulation *. J Biol Chem 278:42330–42339.
dc.source.bibliographicCitationPasquale E Di, Beck-Peccoz P, Persani L. 2004. Hypergonadotropic ovarian failure associated with an inherited mutation of human bone morphogenetic protein-15 (BMP15) gene. Am J Hum Genet 75:106–11.
dc.source.bibliographicCitationPatel DH, Wi SG, Bae HJ. 2009. Modification of overlap extension PCR : A mutagenic approach. 8:183–186.
dc.source.bibliographicCitationPeng J, Li Q, Wigglesworth K, Rangarajan A, Kattamuri C, Peterson RT, Eppig JJ, Thompson TB, Matzuk MM. 2013. Growth differentiation factor 9:bone morphogenetic protein 15 heterodimers are potent regulators of ovarian functions. Proc Natl Acad Sci U S A 110:E776-85.
dc.source.bibliographicCitationPersani L, Rossetti R, Cacciatore C. 2010. Genes involved in human premature ovarian failure. J Mol Endocrinol 45:257–279.
dc.source.bibliographicCitationPersani L, Rossetti R, Cacciatore C, Fabre S. 2011. Genetic defects of ovarian TGF-β-like factors and premature ovarian failure. J Endocrinol Invest 34:244–51.
dc.source.bibliographicCitationPhilibert P, Paris F, Lakhal B, Audran F, Gaspari L, Saâd A, Christin-Maître S, Bouchard P, Sultan C. 2013. NR5A1 (SF-1) gene variants in a group of 26 young women with XX primary ovarian insufficiency. Fertil Steril 99:484–9.
dc.source.bibliographicCitationPieretti M, Zhang F, Fu Y, Warren ST, Oostra BA, Caskey CT, Nelson DL. 1991. Absence of Expression in Fragile X Syndrome of the HIM-7 Gene. Cell 66:817–822.
dc.source.bibliographicCitationPorter S, Clark IM, Kevorkian L, Edwards DR. 2005. The ADAMTS metalloproteinases. Biochem J 386:15–27.
dc.source.bibliographicCitationPratta MA, Yao W, Decicco C, Tortorella MD, Liu R, Copeland RA, Magolda R, Newton RC, Trzaskos JM, Arner EC. 2003. Aggrecan Protects Cartilage Collagen from Proteolytic Cleavage *. Biol Chem 278:45539–45545.
dc.source.bibliographicCitationPrimakoff P, Myles DG. 2002. Penetration , Adhesion , and Fusion in Mammalian Sperm-Egg Interaction. Science (80- ) 2183:2183–2184.
dc.source.bibliographicCitationPyun J a., Kim S, Cha DH, Kwack K. 2013. Epistasis between IGF2R and ADAMTS19 polymorphisms associates with premature ovarian failure. Hum Reprod 28:3146–3154.
dc.source.bibliographicCitationPyun J, Kim S, Kwack K. 2015. Epistasis between polymorphisms in ACVR2B and ADAMTS19 is associated with premature ovarian failure. Menopause 22:212–216.
dc.source.bibliographicCitationQin Y, Choi Y, Zhao H, Simpson JL, Chen Z-J, Rajkovic A. 2007. NOBOX homeobox mutation causes premature ovarian failure. Am J Hum Genet 81:576–581.
dc.source.bibliographicCitationQin Y, Jiao X, Simpson JL, Chen ZJ. 2015. Genetics of primary ovarian insufficiency: New developments and opportunities. Hum Reprod Update 21:787–808.
dc.source.bibliographicCitationRajkovic A, Pangas S a, Matzuk MM. 2006. Follicular Development : Mouse , Sheep , and Human Models. p 318–423.
dc.source.bibliographicCitationRajkovic A, Pangas SA, Ballow D, Suzumori N, Matzuk MM. 2004. NOBOX deficiency disrupts early folliculogenesis and oocyte-specific gene expression. Science 305:1157–9.
dc.source.bibliographicCitationRannikko A, Pakarinen P, Manna PR, Beau I, Misrahi M, Huhtaniemi I. 2002. Functional characterization of the human FSH receptor with an inactivating Ala189Val mutation. Mol Hum Reprod 8:311–317.
dc.source.bibliographicCitationRao C, Foernzler D, Loftus SK, Liu S, McPherson JD, Jungers KA, Apte SS, Pavan WJ, Beier DR. 2003. A defect in a novel ADAMTS family member is the cause of the belted white-spotting mutation. Development 130:4665–72.
dc.source.bibliographicCitationRawlings ND, Barrett AJ. 1995. [13] Evolutionary families of metallopeptidases. In: Enzymology BT-M in, editor. Proteolytic Enzymes: Aspartic and Metallo Peptidases, Academic Press, p 183–228.
dc.source.bibliographicCitationReynaud K, Ph D, Cortvrindt R, Sc M, Verlinde F. 2004. Number of ovarian follicles in human fetuses with the 45 , X karyotype. 81:.
dc.source.bibliographicCitationRhodes JM, Simons M. 2007. The extracellular matrix and blood vessel formation : not just a scaffold. J Cell Mol Med 11:176–205.
dc.source.bibliographicCitationRichards JS. 1994. Hormonal Control of Gene Expression in the Ovary. Endocr Rev 15:725–751.
dc.source.bibliographicCitationRichards JS, Liu Z, Shimada M. 2008. Immune-like mechanisms in ovulation. Endocrinol Metab 19:191–196.
dc.source.bibliographicCitationRobker RL, Russell DL, Espey LL, Lydon JP, Malley BWO, Richards JS. 2000. Progesterone-regulated genes in the ovulation process : ADAMTS-1 and cathepsin L proteases. Proc Natl Acad Sci U S A 97:.
dc.source.bibliographicCitationRoby KF, Son D, Terranova PF. 1999. Alterations of Events Related to Ovarian Function in Tumor Necrosis Factor Receptor Type I Knockout Mice 1. Biol Reprod 1621:1616–1621.
dc.source.bibliographicCitationRodgers RJ, Helen. F I-R, Russell DL. 2003a. Extracellular matrix of the developing ovarian follicle. Semin Reprod Med 24:195–203.
dc.source.bibliographicCitationRodgers RJ, Ir HF. 2002. Extracellular matrix of the bo v ine o v arian membrana granulosa. 191:57–64.
dc.source.bibliographicCitationRodgers RJ, Irving-rodgers HF, Russell DL. 2003b. Review Extracellular matrix of the developing ovarian follicle. Reprod Biol 126:415–424.
dc.source.bibliographicCitationRodgers RJ, Irving-Rodgers HF, Wezel IL Van. 2000. Extracellular matrix in ovarian follicles. Mol Cell Endocrinol 163:73–79.
dc.source.bibliographicCitationRodríguez D, Morrison CJ, Overall CM. 2010. Matrix metalloproteinases : What do they not do ? New substrates and biological roles identified by murine models and proteomics. Biochim Biophys Acta 39–54.
dc.source.bibliographicCitationRosewell KL, Al-alem L, Ph D, Zakerkish F, Mccord L. 2014. Induction of proteinases in the human preovulatory follicle of the menstrual cycle by human chorionic gonadotropin. 1–8.
dc.source.bibliographicCitationRozario T, Desimone DW. 2010. The extracellular matrix in development and morphogenesis : A dynamic view. Dev Biol 341:126–140.
dc.source.bibliographicCitationRubio-Gozalbo, Gubbels CS, Bakker JA, Menheere PPCA, Wodzig WKWH, Land JA. 2010. Gonadal function in male and female patients with classic galactosemia. Hum Reprod Update 16:177–188.
dc.source.bibliographicCitationRussell DL, Brown HM, Dunning KR. 2014. ADAMTS proteases in fertility. Matrix Biol 44–46:54–63.
dc.source.bibliographicCitationSagane K, Yamazaki K, Mizui Y, Tanaka I. 1999. Cloning and chromosomal mapping of mouse ADAM11 ,. Gene 236:79–86.
dc.source.bibliographicCitationSantos MG, Machado AZ, Martins CN, Domenice S, Costa EMF, Nishi MY, Ferraz-de-souza B, Jorge SAC, Pereira CA, Soardi FC, Mello MP De, Maciel-guerra AT, et al. 2014. Homozygous Inactivating Mutation in NANOS3 in Two Sisters with Primary Ovarian Insufficiency. Biomed Res Int 2014:1–9.
dc.source.bibliographicCitationSawyer HR, Smith P, Heath DA, Juengel JL, Wakefield SJ, Mcnatty KP. 2002. Formation of Ovarian Follicles During Fetal Development in Sheep 1. Biol Reprod 1150:1134–1150.
dc.source.bibliographicCitationScacheri PC, Gillanders EM, Subramony SH, Vedanarayanan V, Crowe CA. 2002. Novel mutations in collagen VI genes Expansion of the Bethlem myopathy phenotype. Neurology 58:593–602.
dc.source.bibliographicCitationScheiflinger F, Knöbl P, Trattner B, Plaimauer B, Mohr G, Dockal M, Dorner F, Rieger M. 2003. Nonneutralizing IgM and IgG antibodies to von Willebrand factor-cleaving protease (ADAMTS-13) in a patient with thrombotic thrombocytopenic purpura. Blood 102:3241–3.
dc.source.bibliographicCitationShelling AN. 2010. Premature ovarian failure.
dc.source.bibliographicCitationShiloh Y. 2003. ATM and related protein kinases: safeguarding genome integrity. Nat Rev Cancer 3:155–68.
dc.source.bibliographicCitationShimasaki S, Moore RK, Otsuka F, Erickson GF. 2004. The bone morphogenetic protein system in mammalian reproduction. Endocr Rev 25:72–101.
dc.source.bibliographicCitationShindo T, Kurihara H, Kuno K, Yokoyama H, Wada T, Kurihara Y, Imai T, Wang Y, Ogata M, Nishimatsu H, Moriyama N, Oh-hashi Y, et al. 2000a. ADAMTS-1 : a metalloproteinase-disintegrin essential for normal growth , fertility , and organ morphology and function. J Clin Invest 105:1345–1352.
dc.source.bibliographicCitationShindo T, Kurihara H, Kuno K, Yokoyama H, Wada T, Kurihara Y, Imai T, Wang Y, Ogata M, Nishimatsu H, Moriyama N, Oh-hashi Y, et al. 2000b. ADAMTS-1: a metalloproteinase-disintegrin essential for normal growth, fertility, and organ morphology and function. J Clin Invest 105:1345–52.
dc.source.bibliographicCitationSillem M, Prifti S, Neher M, Runnebaum B. 1998. Extracellular matrix remodelling in the endometrium and its possible relevance to the pathogenesis of endometriosis. Hum Reprod Update 4:730–735.
dc.source.bibliographicCitationSilvera LA, Barrios C. 2012. La matriz extracelular: El ecosistema de la célula. Salud Uninorte 16:9–18.
dc.source.bibliographicCitationSmith MF, Ricke W a., Bakke LJ, Dow MPD, Smith GW. 2002. Ovarian tissue remodeling: role of matrix metalloproteinases and their inhibitors. Mol Cell Endocrinol 191:45–56.
dc.source.bibliographicCitationSoejima K, Matsumoto M, Kokame K, Yagi H, Ishizashi H, Maeda H, Nozaki C. 2003. ADAMTS-13 cysteine-rich / spacer domains are functionally essential for von Willebrand factor cleavage. HEMOSTASIS, Thromb Vasc Biol 102:3232–3238.
dc.source.bibliographicCitationSomerville RPT, Longpre J-M, Jungers KA, Engle JM, Ross M, Evanko S, Wight TN, Leduc R, Apte SS. 2003. Characterization of ADAMTS-9 and ADAMTS-20 as a distinct ADAMTS subfamily related to Caenorhabditis elegans GON-1. J Biol Chem 278:9503–13.
dc.source.bibliographicCitationSoyal SM, Amleh A, Dean J. 2000. FIGalpha, a germ cell-specific transcription factor required for ovarian follicle formation. Development 127:4645–54.
dc.source.bibliographicCitationSpicer LJ, Aad PY. 2007. Insulin-Like Growth Factor ( IGF ) 2 Stimulates Steroidogenesis and Mitosis of Bovine Granulosa Cells Through the IGF1 Receptor : Role of Follicle-Stimulating Hormone and IGF2 Receptor 1. Biol Reprod 27:18–27.
dc.source.bibliographicCitationStamouli A, Sullivan O, Frankel S, Thomas EJ, Richardson MC. 1996. Suppression of matrix metalloproteinase production by hCG in cultures of human luteinized granulosa cells as a model for. J Reprod Fertil 105:235–239.
dc.source.bibliographicCitationStavrou S s., Zhu Y, Cai L, Katz melissa d., Herrera C, Defillo-ricart M, Imperato-mcginley J. 1998. A Novel Mutation of the Human Luteinizing Hormone Receptor in 46XY and 46XX Sisters *. J Clin Endocrinol Metab 83:2091–2098.
dc.source.bibliographicCitationSterchi EE. 2009. Special issue: Metzincin metalloproteinases. Mol Aspects Med 29:255–257.
dc.source.bibliographicCitationStrickland S, Richards WG. 1992. Invasion of the trophoblasts. Cell 71:355–7.
dc.source.bibliographicCitationStrongin A., I C, G. B, BL. M, Grant G A, Goldberg. 1995. Mechanism of cell surface activa- tion of 72-kDa type IV collagenase. Isolation of the activated form of the membrane metalloprotease. J Biol 270:5331–5338.
dc.source.bibliographicCitationSu Y, Wigglesworth K, Pendola FL, Brien MJO, Eppig JJ, Harbor B. 2002. Mitogen-Activated Protein Kinase Activity in Cumulus Cells Is Essential for Gonadotropin-Induced Oocyte Meiotic Resumption and Cumulus Expansion in the Mouse. Endocrinology 143:2221–2232.
dc.source.bibliographicCitationSuwanai AS, Ishii T, Haruna H, Yamataka A, Narumi S. 2013. A report of two novel NR5A1 mutation families : possible clinical phenotype of psychiatric symptoms of anxiety and / or depression. Clin Endocrinol (Oxf) 78:957–965.
dc.source.bibliographicCitationSuzuki A, Saga Y. 2008. Nanos2 suppresses meiosis and promotes male germ cell differentiation. Genes Dev 22:430–435.
dc.source.bibliographicCitationSuzuki H, Tsuda M, Kiso M, Saga Y. 2008. Nanos3 maintains the germ cell lineage in the mouse by suppressing both Bax-dependent and -independent apoptotic pathways. Dev Biol 318:133–142.
dc.source.bibliographicCitationSuzumori N, Yan C, Matzuk MM, Rajkovic A. 2002. Nobox is a homeobox-encoding gene preferentially expressed in primordial and growing oocytes. Mech Dev 111:137–41.
dc.source.bibliographicCitationSybert VP, Mccauley E. 2004. Turner’s Syndrome. N Engl J Med 1227–1238.
dc.source.bibliographicCitationTassone F, Hagerman RJ, Taylor AK, Mills JB, Harris SW, Gane LW, Hagerman PJ. 2000. Clinical Involvement and Protein Expression in Individuals With the FMR1 Premutation. 152:144–152.
dc.source.bibliographicCitationTedesco TA, Miller KL. 1979. Galactosemia : Alterations in Sulfate Metabolism Secondary. Science 666:1395–7.
dc.source.bibliographicCitationThemmen APN, Huhtaniemi IT. 2000. Mutations of Gonadotropins and Gonadotropin Receptors : Elucidating the Physiology and Pathophysiology of Pituitary-Gonadal Function. Endocr Rev 21:551–583.
dc.source.bibliographicCitationTheocharis AD, Skandalis SS, Gialeli C, Karamanos NK. 2015. Extracellular matrix structure. Adv Drug Deliv Rev 97:4–27.
dc.source.bibliographicCitationTimpl R, Brown JC. 1996. Supramolecular assembly of basement membranes. BioEssays news Rev Mol Cell Dev Biol 18:123–32.
dc.source.bibliographicCitationToledo SP, Brunner HG, Kraaij R, Post M, Dahia PL, Hayashida CY, Themmen APKH. 1996.
dc.source.bibliographicCitationToniolo D. 2006. X-linked premature ovarian failure : a complex disease. Genet Dis 16:293–300.
dc.source.bibliographicCitationTortorella M, Pratta M, Liu RQ, Abbaszade I, Ross H, Burn T, Arner E. 2000. The thrombospondin motif of Aggrecanase-1 (ADAMTS-4) is critical for aggrecan substrate recognition and cleavage. J Biol Chem 275:25791–25797.
dc.source.bibliographicCitationTortorella MD, Malfait A, Deccico C, Arner E. 2001. The role of ADAM-TS4 ( aggrecanase-1 ) and ADAM-TS5 ( aggrecanase-2 ) in a model of cartilage degradation. Osteoarthr Cartil 4:539–552.
dc.source.bibliographicCitationTortorella MD, Malfait F, Barve RA, Shieh H-S, Malfait A-M. 2009. A review of the ADAMTS family, pharmaceutical targets of the future. Curr Pharm Des 15:2359–74.
dc.source.bibliographicCitationTouraine P, Beau I, Gougeon A, Meduri G, Desroches A, Pichard C, Detoeuf M, Paniel B, Prieur M, Zorn J, Milgrom E, Kuttenn F, et al. 1999. New Natural Inactivating Mutations of the Follicle-Stimulating Hormone Receptor : Correlations between Receptor Function and Phenotype. Mol Endocrinol 13:1844–1854.
dc.source.bibliographicCitationTousseyn T, Jorissen E, Reiss K, Hartmann D. 2006. (Make) stick and cut loose - Disintegrin metalloproteases in development and disease. Birth Defects Res Part C - Embryo Today Rev 78:24–46.
dc.source.bibliographicCitationTsuda M, Sasaoka Y, Kiso M, Abe K, Haraguchi S, Kobayashi S. 2003. Conserved Role of nanos Proteins in Germ Cell Development. Science (80- ) 301:1239–41.
dc.source.bibliographicCitationTyfield L, Reichardt J, Fridovich-Keil J, Croke DT, Elsas LJ, Strobl W, Kozak L, Coskun T, Novelli G, Okano Y, Zekanowski C, Shin Y, et al. 1999. Classical galactosemia and mutations at the galactose-1-phosphate uridyl transferase (GALT) gene. Hum Mutat 13:417–30.
dc.source.bibliographicCitationUda M, Ottolenghi C, Crisponi L, Garcia JE, Deiana M, Kimber W, Forabosco A, Cao A, Schlessinger D, Pilia G. 2004. Foxl2 disruption causes mouse ovarian failure by pervasive blockage of follicle development. Hum Mol Genet 13:1171–81.
dc.source.bibliographicCitationVakonakis I, Campbell ID. 2007. Extracellular matrix : from atomic resolution to ultrastructure. Curr Opin Cell Biol 19:578–583.
dc.source.bibliographicCitationVenter JC, Adams MD, Myers EW, Li PW, Mural RJ, Sutton GG, Smith HO, Yandell M, Evans CA, Holt RA, Gocayne JD, Amanatides P, et al. 2001. The Sequence of the Human Genome. Hum Genome 291:.
dc.source.bibliographicCitationWagenseil JE, Mecham RP. 2007. New insights into elastic fiber assembly. Birth Defects Res Part C - Embryo Today Rev 81:229–240.
dc.source.bibliographicCitationWang P, Tortorella M, England K, Malfait A, Thomas G, Arner EC, Pei D. 2004. Proprotein Convertase Furin Interacts with and Cleaves Pro-ADAMTS4 ( Aggrecanase-1 ) in the trans -Golgi Network *. J Biol Chem 279:15434–15440.
dc.source.bibliographicCitationWassarman PM, Jovine L, Litscher ES. 2004. Mouse zona pellucida genes and glycoproteins. Cytogenet Genome Res 234:228–234.
dc.source.bibliographicCitationWeber. Kt, Facc. Pier Anversa, Paul W. Armstrong M, Facc, Christian G. Brilla, Md, Plrd, John C. Burnett. Jr. M, John M. Cruickshank et al.,1992. Remodeling and reparation of the cardiovascular system. J Am Coll Cardiol 20:3–16.
dc.source.bibliographicCitationWeiss A, Attisano L. 2013. The TGFbeta Superfamily Signaling Pathway. Wires Dev Biol 2:47–63.
dc.source.bibliographicCitationWeiss J, Meeks JJ, Hurley L, Raverot G, Frassetto A, Jameson JL. 2003. Sox3 Is Required for Gonadal Function , but Not Sex Determination , in Males and Females. 23:8084–8091.
dc.source.bibliographicCitationWhite JM. 2003. ADAMs : modulators of cell – cell and cell – matrix interactions. Curr Opin Cell Biol 15:598–606.
dc.source.bibliographicCitationWoad KJ, Watkins WJ, Prendergast D, Shelling AN. 2006. The genetic basis of premature ovarian failure. Aust New Zeal Obstet Gynaecol 46:242–244.
dc.source.bibliographicCitationWolfram B, Franz-Xaver G-R, Stiickler W. 1993. Astacins , serralysins , snake venom and matrix metalloproteinases exhibit identical zinc-binding environments ( HEXXHXXGXXH and Met-turn ) and topologies and should be grouped into a common family , the. FEBS Lett 331:134–140.
dc.source.bibliographicCitationWu X, Wang B, Dong Z, Zhou S, Liu Z, Shi G, Cao Y, Xu Y. 2013. A NANOS3 mutation linked to protein degradation causes premature ovarian insufficiency. Cell Death Dis 4:e825.
dc.source.bibliographicCitationYan C, Wang P, Demayo J, Demayo FJ, Elvin JA, Carino C, Prasad S V, Skinner SS, Dunbar BS, Dube JL, Celeste AJ, Matzuk MM. 2001. Synergistic Roles of Bone Morphogenetic Protein 15 and Growth Differentiation Factor 9 in Ovarian Function. Mol Endocrinol 9:854–866.
dc.source.bibliographicCitationYu H, Mouw JK, Weaver VM. 2010. Forcing form and function : biomechanical regulation of tumor evolution. Trends Cell Biol 21:47–56.
dc.source.bibliographicCitationYu W, Yu SC, Meng Q, Brew K, Woessner JF. 2000. TIMP-3 Binds to Sulfated Glycosaminoglycans of the Extracellular Matrix * portant for the cellular regulation of activity of the ma-. J Biol Chem 275:31226–31232.
dc.source.bibliographicCitationYurchenco P, Schittny J. 1990. Molecular architecture of basement membranes . FASEB J 4:1577–1590.
dc.source.bibliographicCitationZhang X, Fei K, Agbas A, Yan L, Zhang J, O’Reilly B, Deutzmann R, Sarras MP. 2002. Structure and function of an early divergent form of laminin in hydra: A structurally conserved ECM component that is essential for epithelial morphogenesis. Dev Genes Evol 212:159–172.
dc.source.bibliographicCitationZhao H, Chen Z-J, Qin Y, Shi Y, Wang S, Choi Y, Simpson JL, Rajkovic A. 2008. Transcription factor FIGLA is mutated in patients with premature ovarian failure. Am J Hum Genet 82:1342–8.
dc.source.bibliographicCitationZhao Y, Luck MR. 1995. Gene expression and protein distribution of collagen, fibronectin and laminin in bovine follicles and corpora lutea. J Reprod Fertil 104:115–123.
dc.source.bibliographicCitationZheng X, Chung D, Takayama TK, Majerus EM, Sadler JE, Fujikawa K. 2001. Structure of von Willebrand factor-cleaving protease (ADAMTS13), a metalloprotease involved in thrombotic thrombocytopenic purpura. J Biol Chem 276:41059–63.
dc.source.bibliographicCitationZinn R, Ross JL, Epstein C. 1998. Turner syndrome and haploinsufficiency. Curr Opin Genet Dev 8:322–327.
dc.source.bibliographicCitationZlotogora J, Sagi M, Cohen T. 1983. The blepharophimosis, ptosis, and epicanthus inversus syndrome: delineation of two types. Am J Hum Genet 35:1020–7.
dc.rights.licenciaEL AUTOR, manifiesta que la obra objeto de la presente autorización es original y la realizó sin violar o usurpar derechos de autor de terceros, por lo tanto la obra es de exclusiva autoría y tiene la titularidad sobre la misma. PARGRAFO: En caso de presentarse cualquier reclamación o acción por parte de un tercero en cuanto a los derechos de autor sobre la obra en cuestión, EL AUTOR, asumirá toda la responsabilidad, y saldrá en defensa de los derechos aquí autorizados; para todos los efectos la universidad actúa como un tercero de buena fe. EL AUTOR, autoriza a LA UNIVERSIDAD DEL ROSARIO, para que en los términos establecidos en la Ley 23 de 1982, Ley 44 de 1993, Decisión andina 351 de 1993, Decreto 460 de 1995 y demás normas generales sobre la materia, utilice y use la obra objeto de la presente autorización. -------------------------------------- POLITICA DE TRATAMIENTO DE DATOS PERSONALES. Declaro que autorizo previa y de forma informada el tratamiento de mis datos personales por parte de LA UNIVERSIDAD DEL ROSARIO para fines académicos y en aplicación de convenios con terceros o servicios conexos con actividades propias de la academia, con estricto cumplimiento de los principios de ley. Para el correcto ejercicio de mi derecho de habeas data cuento con la cuenta de correo habeasdata@urosario.edu.co, donde previa identificación podré solicitar la consulta, corrección y supresión de mis datos.


Archivos en el ítem

Thumbnail

Este ítem aparece en la(s) siguiente(s) colección(ones)

 

Reconocimientos: