dc.contributor.advisorArévalo Leal, José Sinay
dc.contributor.advisorMorón Duarte, Lina Sofía
dc.creatorHerrera Malo, Yariela Edith
dc.creatorArévalo Leal, José Sinay
dc.creatorMejía López, Arturo
dc.date.accessioned2014-01-16T19:21:39Z
dc.date.available2014-01-16T19:21:39Z
dc.date.created2013-11-22
dc.date.issued2014-01-16
dc.identifier.urihttp://repository.urosario.edu.co/handle/10336/4835
dc.descriptionIntroducción: los tumores neuroendocrinos gastroenteropancreáticos se diagnostican en estadio avanzado en 60 - 80% de los pacientes y las opciones terapéuticas son limitadas. Se realizó una revisión sobre el beneficio clínico del tratamiento con [177Lu - DOTA - Tyr3] - Octreotate en pacientes con enfermedad metastásica o inoperable. Objetivos: evaluar la eficacia, impacto en calidad de vida y toxicidad de la terapia con 177Lu DOTATE en pacientes con tumores neuroendocrinos gastroenteropancreáticos avanzados. Materiales y Métodos: se condujo una revisión sistemática de la literatura mediante la búsqueda de estudios clínicos prospectivos y retrospectivos en bases electrónicas (MEDLINE, EMBASE, LILACS, SCIELO, OVID y la Biblioteca Cochrane) de cualquier idioma, año y estado de publicación. Se incluyeron 5 estudios, por la heterogeneidad existente entre los estudios no se realizó un metaanálisis. Resultados: la respuesta tumoral global fue del 45 - 57%, la enfermedad permaneció estable en 27% - 38% y progresó en 6% - 21% de casos en las series incluidas. El tiempo libre de progresión osciló entre 31 - 40 meses y la sobrevida global de 31– 51 meses. Se observó toxicidad hematológica grado 3-4 hasta en 9.5% de pacientes. Hubo mejoría significativa en la calidad de vida de pacientes tratados con 177LuDOTATATE. Conclusiones: la terapia con 177Lu- DOTATATE ofrece un beneficio clínico a los pacientes con tumores neuroendocrinos bien diferenciados avanzados por su impacto positivo en calidad de vida, control de síntomas, ralentiza la progresión tumoral y su toxicidad es baja.
dc.description.abstractGastroenteropancreatic neuroendocrine tumors are diagnosed in advanced state in approximately 60 – 80% of patients, their treatment options are limited. We reviewed the clinical benefit of radionuclide therapy with 177Lu – DOTA – Tyr3] – Octreotate in patients with advanced or inoperable disease. Objective: To assess the efficacy, impact on quality of life and side effects of therapy with 177Lu DOTATE in patients with advanced gastroenteropancreatic neuroendocrine tumors. Materials and Methods: We conducted a systematic review using a peer – reviewed search for clinical prospective and retrospective trials. This search was done in electronic databases (MEDLINE, EMBASE, LILACS, SCIELO, OVID and the Cochrane Library) without language, year or publication status limitations. We included 5 studies; because they were heterogeneous no meta analysis was done. Results: Overall tumor response was seen in 45- 57% of cases, stable disease in 27-38% and progression in 6-21% of cases included in the studies. Time to progression was 31 - 40 months and overall survival 31 – 51 months. Hematologic toxicity grade 3-4 presented in up to 9.5% of patients. Treatment had a significant positive impact in quality of life. Conclusions: Therapy with 177Lu- DOTATATE offers a clinical benefit to patients with advanced gastroenteropancreatic neuroendocrine tumors by improving quality of life, controlling symptoms and limiting progression of disease. The toxicity of the drug is low.
dc.format.mimetypeapplication/pdf
dc.language.isospa
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/2.5/co/
dc.sourceinstname:Universidad del Rosario
dc.sourcereponame:Repositorio Institucional EdocUR
dc.subject177Lu- DOTATATE
dc.subject177Lu-octreotate
dc.subjectcarcinoma neuroendocrino
dc.subjectgastroenteropancreatic neuroendocrine tumor
dc.subjectreceptores de somatostatina
dc.subject.lembCarcinoma neuroendocrino
dc.subject.lembMedicina nuclear::Investigaciones
dc.subject.lembNeoplasias pancreáticas
dc.subject.lembOctreótido::Utilización
dc.subject.lembTumores neuroendocrinos::Diagnóstico
dc.subject.lembTUMORES NEUROENDOCRINOS - TRATAMIENTO
dc.title[177Lu – DOTA – Tyr3] – OCTREOTATE para el tratamiento de tumores neuroendocrinos gastroenteropancreáticos. Revisión sistemática de la literatura.
dc.typeinfo:eu-repo/semantics/bachelorThesis
dc.publisherUniversidad del Rosario
dc.creator.degreeEspecialista en Medicina Nuclear
dc.publisher.programEspecialización en Medicina Nuclear
dc.publisher.departmentFacultad de Medicina
dc.subject.keyword177Lu- DOTATATE
dc.subject.keyword177Lu-octreotate
dc.subject.keywordgastroenteropancreatic neuroendocrine tumor
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.type.spaTrabajo de grado
dc.rights.accesoAbierto (Texto completo)
dc.type.hasVersioninfo:eu-repo/semantics/acceptedVersion
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