dc.creatorPatarroyo, Manuel A. 
dc.creatorBermudez, Adriana 
dc.creatorLópez, Carolina 
dc.creatorYepes, Gloria 
dc.creatorPatarroyo, Manuel E. 
dc.date.accessioned2014-08-12T16:06:42Z
dc.date.available2014-08-12T16:06:42Z
dc.date.created2010-03
dc.identifier.issnISSN:1932-6203
dc.identifier.urihttp://repository.urosario.edu.co/handle/10336/8806
dc.description.abstractT-cell receptor gene rearrangements were studied in Aotus monkeys developing high antibody titers and sterilizing immunity against the Plasmodium falciparum malaria parasite upon vaccination with the modified synthetic peptide 24112, which was identified in the Merozoite Surface Protein 2 (MSP-2) and is known to bind to HLA-DR beta 1*0403 molecules with high capacity. Spectratyping analysis showed a preferential usage of V beta 12 and V beta 6 TCR gene families in 67% of HLA-DR beta 1*0403-like genotyped monkeys. Docking of peptide 24112 into the HLA-DR beta 1*0401-HA peptide-HA1.7TCR complex containing the VDJ rearrangements identified in fully protected monkeys showed a different structural signature compared to nonprotected monkeys. These striking results show the exquisite specificity of the TCR/pMHCII complex formation needed for inducing sterilizing immunity and provide important hints for a logical and rational methodology to develop multiepitopic, minimal subunit-based synthetic vaccines against infectious diseases, among them malaria.
dc.format.mediumRecurso electrónico
dc.format.mimetypeapplication/pdf
dc.language.isoeng
dc.relation.ispartofPLOS ONE ISSN: 1932-6203 V. 5 N. 3 Mar 19, 2010
dc.relation.urihttp://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0009771
dc.sourcereponame:Repositorio Institucional EdocUR
dc.sourceinstname:Universidad del Rosario
dc.subject.ddc616.9362
dc.title3D Analysis of the TCR/pMHCII Complex Formation in Monkeys Vaccinated with the First Peptide Inducing Sterilizing Immunity against Human Malaria
dc.typearticle
dc.audienceComunidad Rosarista
dc.publisherUniversidad del Rosario
dc.subject.keywordT-CELL-RECEPTOR
dc.subject.keywordMHC CLASS-II
dc.subject.keywordNEW-WORLD MONKEYS
dc.subject.keywordRED-BLOOD-CELLS
dc.subject.keywordPLASMODIUM-FALCIPARUM
dc.subject.keywordCRYSTAL-STRUCTURE
dc.subject.keywordHLA-DR4 DRA-ASTERISK-0101
dc.subject.keywordAOTUS-NANCYMAAE
dc.subject.keywordAMINO-ACIDS
dc.subject.keywordDIVERSITY
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.subject.decsMalaria
dc.subject.decsPlasmodium
dc.subject.decsEnfermedades autoinmunes
dc.subject.decsInmunología
dc.type.spaArtículo
dc.rights.accesoAbierto (Texto completo)
dc.type.hasVersioninfo:eu-repo/semantics/acceptedVersion
dc.format.tipoDocumentos
dc.rights.licenciaEL AUTOR, manifiesta que la obra objeto de la presente autorización es original y la realizó sin violar o usurpar derechos de autor de terceros, por lo tanto la obra es de exclusiva autoría y tiene la titularidad sobre la misma.
dc.creator.googlePatarroyo, Manuel A.
dc.creator.googleBermúdez, Adriana
dc.creator.googleLópez, Carolina
dc.creator.googleYepes, Gloria
dc.creator.googlePatarroyo, Manuel E.


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