dc.creatorPatarroyo, Manuel E
dc.creatorPatricia Alba, Martha
dc.creatorCurtidor, Hernando
dc.date.accessioned2014-08-12T16:23:29Z
dc.date.available2014-08-12T16:23:29Z
dc.date.created2014-02
dc.identifier.issnISSN:ISSN:ISSN:1932-6203spa
dc.identifier.urihttp://repository.urosario.edu.co/handle/10336/8808
dc.description.abstractPlasmodium falciparum (Pf) malaria causes 200 million cases worldwide, 8 million being severe and complicated leading to similar to 1 million deaths and similar to 100,000 abortions annually. Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) has been implicated in cytoadherence and infected erythrocyte rosette formation, associated with cerebral malaria; chondroitin sulphate-A attachment and infected erythrocyte sequestration related to pregnancy-associated malaria and other severe forms of disease. An endothelial cell high activity binding peptide is described in several of this similar to 300 kDa hypervariable protein's domains displaying a conserved motif (GACxPxRRxxLC); it established H-bonds with other binding peptides to mediate red blood cell group A and chondroitin sulphate attachment. This motif (when properly modified) induced PfEMP1-specific strain-transcending, fully-protective immunity for the first time in experimental challenge in Aotus monkeys, opening the way forward for a long sought-after vaccine against severe malaria.spa
dc.format.mediumRecurso Electrónico
dc.format.mimetypeapplication/pdfspa
dc.language.isoengspa
dc.relation.ispartofPLOS ONE ISSN: 1932-6203 V. 9 N. 2 Feb 7, 2014spa
dc.relation.urihttp://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0088420spa
dc.sourceinstname:Universidad del Rosariospa
dc.sourcereponame:Repositorio Institucional EdocURspa
dc.subject.ddc616.9362spa
dc.titleUsing the PfEMP1 Head Structure Binding Motif to Deal a Blow at Severe Malariaspa
dc.typeinfo:eu-repo/semantics/articlespa
dc.audienceComunidad Rosarista
dc.publisherUniversidad del Rosario
dc.subject.keywordERYTHROCYTE-MEMBRANE PROTEIN-1spa
dc.subject.keywordCHONDROITIN-SULFATE-Aspa
dc.subject.keywordPLASMODIUM-FALCIPARUMspa
dc.subject.keywordANTIMALARIAL VACCINEspa
dc.subject.keywordPLACENTAL MALARIAspa
dc.subject.keywordALPHA-DOMAINSspa
dc.subject.keywordEXPRESSIONspa
dc.subject.keywordANTIBODIESspa
dc.subject.keywordPARASITESspa
dc.subject.keywordPEPTIDESspa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccessspa
dc.subject.decsPlasmodiumspa
dc.subject.decsMalariaspa
dc.subject.decsInmunologíaspa
dc.type.spaArtículospa
dc.rights.accesoAbierto (Texto Completo)spa
dc.type.hasVersioninfo:eu-repo/semantics/acceptedVersionspa
dc.format.tipoDocumentosspa
dc.rights.licenciaEL AUTOR, manifiesta que la obra objeto de la presente autorización es original y la realizó sin violar o usurpar derechos de autor de terceros, por lo tanto la obra es de exclusiva autoría y tiene la titularidad sobre la misma.


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