dc.creatorVatin, Magalie 
dc.creatorBurgio, Gaetan 
dc.creatorRenault, Gilles 
dc.creatorLaissue, Paul 
dc.creatorFirlej, Virginie 
dc.creatorMondon, Françoise 
dc.creatorMontagutelli, Xavier 
dc.creatorVaiman, Daniel 
dc.creatorSerres, Catherine 
dc.creatorZiyyat, Ahmed 
dc.date.accessioned2014-08-12T18:45:21Z
dc.date.available2014-08-12T18:45:21Z
dc.date.created2012-08-16
dc.identifier.issnISSN:1932-6203
dc.identifier.urihttp://repository.urosario.edu.co/handle/10336/8814
dc.description.abstractRecurrent spontaneous abortion (RSA) is defined as the loss of three or more consecutive pregnancies during the first trimester of embryonic intrauterine development. This kind of human infertility is frequent among the general population since it affects 1 to 5% of women. In half of the cases the etiology remains unelucidated. In the present study, we used interspecific recombinant congenic mouse strains (IRCS) in the aim to identify genes responsible for embryonic lethality. Applying a cartographic approach using a genotype/phenotype association, we identified a minimal QTL region, of about 6 Mb on chromosome 1, responsible for a high rate of embryonic death (similar to 30%). Genetic analysis suggests that the observed phenotype is linked to uterine dysfunction. Transcriptomic analysis of the uterine tissue revealed a preferential deregulation of genes of this region compared to the rest of the genome. Some genes from the QTL region are associated with VEGF signaling, mTOR signaling and ubiquitine/proteasome-protein degradation pathways. This work may contribute to elucidate the molecular basis of a multifactorial and complex human disorder as RSA.
dc.format.mediumRecurso electrónico
dc.format.mimetypeapplication/pdf
dc.language.isoeng
dc.relation.ispartofPLOS ONE ISSN: 1932-6203 V. 7 N. 8 Ago 16, 2012
dc.relation.urihttp://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0043356
dc.sourcereponame:Repositorio Institucional EdocUR
dc.sourceinstname:Universidad del Rosario
dc.subject.ddc618.392
dc.subject.lembEmbarazo
dc.subject.lembAborto
dc.subject.lembPreeclampsia
dc.subject.lembGinecología
dc.titleRefined mapping of a quantitative trait locus on chromosome 1 responsible for mouse embryonic death
dc.typearticle
dc.audienceComunidad Rosarista
dc.publisherUniversidad del Rosario
dc.subject.keywordRECURRENT MISCARRIAGE
dc.subject.keywordSPONTANEOUS-ABORTION
dc.subject.keywordCYTOGENETIC ANALYSIS
dc.subject.keywordCELL-PROLIFERATION
dc.subject.keywordMICE
dc.subject.keywordGENE
dc.subject.keywordPREGNANCIES
dc.subject.keywordPREECLAMPSIA
dc.subject.keywordDISRUPTION
dc.subject.keywordLETHALITY
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.type.spaArtículo
dc.rights.accesoAbierto (Texto completo)
dc.type.hasVersioninfo:eu-repo/semantics/acceptedVersion
dc.format.tipoDocumentos
dc.rights.licenciaEL AUTOR, manifiesta que la obra objeto de la presente autorización es original y la realizó sin violar o usurpar derechos de autor de terceros, por lo tanto la obra es de exclusiva autoría y tiene la titularidad sobre la misma.
dc.creator.googleVatin, Magalie
dc.creator.googleBurgio, Gaetan
dc.creator.googleRenault, Gilles
dc.creator.googleLaissue, Paul
dc.creator.googleFirlej, Virginie
dc.creator.googleMondon, Françoise
dc.creator.googleMontagutelli, Xavier
dc.creator.googleVaiman, Daniel
dc.creator.googleSerres, Catherine
dc.creator.googleZiyyat, Ahmed


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