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What is next after the genes for autoimmunity?

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dc.audienceComunidad Rosaristaspa
dc.creatorCastiblanco, John
dc.creatorArcos-Burgos, Mauricio
dc.creatorAnaya, Juan-Manuel
dc.creator.googleCastiblanco, John
dc.creator.googleArcos-Burgos, Mauricio
dc.creator.googleAnaya, Juan-Manuel
dc.date.accessioned2014-08-11T16:58:05Z
dc.date.available2014-08-11T16:58:05Z
dc.date.created2013-09
dc.date.issued2013
dc.description.abstractClinical pathologies draw us to envisage disease as either an independent entity or a diverse set of traits governed by common physiopathological mechanisms, prompted by environmental assaults throughout life. Autoimmune diseases are not an exception, given they represent a diverse collection of diseases in terms of their demographic profile and primary clinical manifestations. Although they are pleiotropic outcomes of non-specific disease genes underlying similar immunogenetic mechanisms, research generally focuses on a single disease. Drastic technologic advances are leading research to organize clinical genomic multidisciplinary approaches to decipher the nature of human biological systems. Once the currently costly omic-based technologies become universally accessible, the way will be paved for a cleaner picture to risk quantification, prevention, prognosis and diagnosis, allowing us to clearly define better phenotypes always ensuring the integrity of the individuals studied. However, making accurate predictions for most autoimmune diseases is an ambitious challenge, since the understanding of these pathologies is far from complete. Herein, some pitfalls and challenges of the genetics of autoimmune diseases are reviewed, and an approximation to the future of research in this field is presented.eng
dc.format.mediumRecurso electrónicospa
dc.format.mimetypeapplication/pdf
dc.format.tipoDocumentospa
dc.identifier.issnISSN:17417015
dc.identifier.urihttp://repository.urosario.edu.co/handle/10336/8770
dc.language.isoeng
dc.publisherUniversidad del Rosariospa
dc.relation.citationIssueNo. 1
dc.relation.citationTitleBMC Medicine
dc.relation.citationVolumeVol. 11
dc.relation.ispartofBMC Medicine ISSN: 17417015 V. 11 N. 1 Sep, 2014spa
dc.relation.urihttp://www.biomedcentral.com/content/pdf/1741-7015-11-197.pdf
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto completo)spa
dc.rights.licenciaEL AUTOR, manifiesta que la obra objeto de la presente autorización es original y la realizó sin violar o usurpar derechos de autor de terceros, por lo tanto la obra es de exclusiva autoría y tiene la titularidad sobre la misma.spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.ddcAntropología física
dc.subject.decsEnfermedades autoinmunesspa
dc.subject.decsMedicina transnacionalspa
dc.subject.decsGenéticaspa
dc.subject.decsGenoma humanospa
dc.subject.keywordAutoimmunityeng
dc.subject.keywordCommoneng
dc.subject.keywordGeneticseng
dc.subject.keywordGenomicseng
dc.subject.keywordPersonalizedeng
dc.subject.keywordPredictive medicineeng
dc.subject.keywordPolyautoimmunityeng
dc.subject.keywordTranslational medicineeng
dc.titleWhat is next after the genes for autoimmunity?spa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/acceptedVersion
dc.type.spaArtículospa
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