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The insulin-like growth factor system is modulated by exercise in breast cancer survivors: a systematic review and metaanalysis
dc.contributor.gruplac | Centro de Estudios en Medición de la Actividad Física (CEMA) | spa |
dc.creator | Meneses Echávez, José Francisco | |
dc.creator | González Jiménez, Emilio | |
dc.creator | Schmidt Rio-Valle, Jacqueline | |
dc.creator | Correa Bautista, Jorge Enrique | |
dc.creator | Ramírez-Vélez, Robinson | |
dc.creator | Izquierdo, Mikel | |
dc.creator.google | Meneses Echávez, Jose Francisco | |
dc.creator.google | González Jiménez, Emilio | |
dc.creator.google | Schmidt Rio-Valle, Jacqueline | |
dc.creator.google | Correa Bautista, Jorge Enrique | |
dc.creator.google | Izquierdo, Mikel | |
dc.creator.google | Ramírez-Vélez, Robinson | |
dc.date.accessioned | 2018-02-21T20:08:13Z | |
dc.date.available | 2018-02-21T20:08:13Z | |
dc.date.created | 2016 | |
dc.date.issued | 2016 | |
dc.description.abstract | Background: Insulin-like growth factors (IGF´s) play a crucial role in controlling cancer cell proliferation, differentiation and apoptosis. Exercise has been postulated as an effective intervention in improving cancerrelated outcomes and survival, although its effects on IGF´s are not well understood. This meta-analysis aimed to determine the effects of exercise in modulating IGF´s system in breast cancer survivors. Methods: Databases of PuMed, EMBASE, Cochrane Central Register of Controlled Trials, EMBASE, ClinicalTrials. gov, SPORTDiscus, LILACS and Scopus were systematically searched up to November 2014. Effect estimates were calculated through a random-effects model of meta-analysis according to the DerSimonian and Laird method. Heterogeneity was evaluated with the I 2 test. Risk of bias and methodological quality were evaluated using the PEDro score. Results: Five randomized controlled trials (n = 235) were included. Most women were post-menopausal. Highquality and low risk of bias were found (mean PEDro score = 6.2 ± 1). Exercise resulted in significant improvements on IGF-I, IGF-II, IGFBP-I, IGFBP-3, Insulin and Insulin resistance (P 0.05). Non-significant differences were found for Glucose. Aerobic exercise improved IGF-I, IGFBP-3 and Insulin. No evidence of publication bias was detected by Egger´s test (p = 0.12). Conclusions: Exercise improved IGF´s in breast cancer survivors. These findings provide novel insight regarding the molecular effects of exercise on tumoral microenvironment, apoptosis and survival in breast cancer survivors. | eng |
dc.format.mimetype | application/pdf | |
dc.identifier.uri | http://repository.urosario.edu.co/handle/10336/14426 | |
dc.language.iso | eng | |
dc.relation.citationEndPage | 10 | |
dc.relation.citationStartPage | 2 | |
dc.relation.citationTitle | BMC Cancer | |
dc.relation.ispartof | BMC Cancer, ISSN 1471-2407, (2016); pp. 2-10 | spa |
dc.relation.uri | https://bmccancer.biomedcentral.com/articles/10.1186/s12885-016-2733-z | |
dc.rights.accesRights | info:eu-repo/semantics/openAccess | |
dc.rights.acceso | Abierto (Texto Completo) | spa |
dc.rights.uri | http://www.sap.org.ar/publicaciones/contenidos/28/consentimiento-informado.html | |
dc.source.instname | instname:Universidad del Rosario | |
dc.source.reponame | reponame:Repositorio Institucional EdocUR | |
dc.subject | Breast Cancer | spa |
dc.subject | Exercise | spa |
dc.subject | Insulin-Like Growth Factor Binding Proteins | spa |
dc.subject | Tumor Microenvironment | spa |
dc.subject.ddc | Fisiología humana | |
dc.subject.lemb | Cáncer | spa |
dc.title | The insulin-like growth factor system is modulated by exercise in breast cancer survivors: a systematic review and metaanalysis | spa |
dc.type | article | eng |
dc.type.hasVersion | info:eu-repo/semantics/publishedVersion | |
dc.type.spa | Artículo | spa |
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