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Development of designed site-directed pseudopeptide-peptido-mimetic immunogens as novel minimal subunit-vaccine candidates for malaria

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dc.audienceComunidad Rosaristaspa
dc.creatorLozano, Jose Manuel
dc.creatorLesmes, Liliana P
dc.creatorCarreno, Luisa
dc.creatorGallego, Gina M.
dc.creatorPatarroyo, Manuel E.
dc.creator.googleLozano, José Manuel
dc.creator.googleLesmes, Liliana P.
dc.creator.googleCarreño, Luisa F.
dc.creator.googleGallego, Gina M.
dc.creator.googlePatarroyo, Manuel Elkin
dc.date.accessioned2014-08-12T16:59:41Z
dc.date.available2014-08-12T16:59:41Z
dc.date.created2010-12
dc.date.issued2010
dc.description.abstractSynthetic vaccines constitute the most promising tools for controlling and preventing infectious diseases. When synthetic immunogens are designed from the pathogen native sequences, these are normally poorly immunogenic and do not induce protection, as demonstrated in our research. After attempting many synthetic strategies for improving the immunogenicity properties of these sequences, the approach consisting of identifying high binding motifs present in those, and then performing specific changes on amino-acids belonging to such motifs, has proven to be a workable strategy. In addition, other strategies consisting of chemically introducing non-natural constraints to the backbone topology of the molecule and modifying the a-carbon asymmetry are becoming valuable tools to be considered in this pursuit. Non-natural structural constraints to the peptide backbone can be achieved by introducing peptide bond isosters such as reduced amides, partially retro or retro-inverso modifications or even including urea motifs. The second can be obtained by strategically replacing L-amino-acids with their enantiomeric forms for obtaining both structurally site-directed designed immunogens as potential vaccine candidates and their Ig structural molecular images, both having immunotherapeutic effects for preventing and controlling malaria.eng
dc.format.mediumRecurso electrónicospa
dc.format.mimetypeapplication/pdf
dc.format.tipoDocumentospa
dc.identifier.issnISSN:1420-3049
dc.identifier.urihttp://repository.urosario.edu.co/handle/10336/8812
dc.language.isoeng
dc.publisherUniversidad del Rosariospa
dc.relation.citationIssueNo. 12
dc.relation.citationTitleMOLECULES
dc.relation.citationVolumeVol. 15
dc.relation.ispartofMOLECULES ISSN: 1420-3049 V. 15 N. 12 Dic, 2010spa
dc.relation.urihttp://www.mdpi.com/1420-3049/15/12/8856
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto completo)spa
dc.rights.licenciaEL AUTOR, manifiesta que la obra objeto de la presente autorización es original y la realizó sin violar o usurpar derechos de autor de terceros, por lo tanto la obra es de exclusiva autoría y tiene la titularidad sobre la misma.spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.ddcIncidencia & prevención de la enfermedad
dc.subject.decsMalariaspa
dc.subject.decsEnfermedades autoinmunesspa
dc.subject.decsEnfermedades infecciosasspa
dc.subject.decsInmunologíaspa
dc.subject.keywordPLASMODIUM-FALCIPARUM MALARIAeng
dc.subject.keywordMEROZOITE SURFACE PROTEIN-1eng
dc.subject.keywordSOLID-PHASE SYNTHESISeng
dc.subject.keywordMHC CLASS-IIeng
dc.subject.keywordCRYSTAL-STRUCTUREeng
dc.subject.keywordAMINO-ACIDSeng
dc.subject.keywordSYNTHETIC PEPTIDESeng
dc.subject.keywordIMMUNE EVASIONeng
dc.subject.keywordBOND ANALOGeng
dc.subject.keywordRECOGNITIONeng
dc.titleDevelopment of designed site-directed pseudopeptide-peptido-mimetic immunogens as novel minimal subunit-vaccine candidates for malariaspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/acceptedVersion
dc.type.spaArtículospa
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