Ítem
Acceso Abierto

Identification and Diversity of Killer Cell Ig-Like Receptors in Aotus vociferans, a New World Monkey

Mostrar el registro sencillo de la publicación
dc.audienceComunidad Rosaristaspa
dc.creatorGarzón-Ospina, Diego
dc.creatorLópez, Carolina
dc.creatorCadavid, Luis
dc.creatorPatarroyo, Manuel Elkin
dc.creatorPatarroyo, Manuel A.
dc.creator.googleGarzón-Ospina, Diego
dc.creator.googleLópez, Carolina
dc.creator.googleCadavid, Luis F.
dc.creator.googlePatarroyo, Manuel E.
dc.creator.googlePatarroyo, Manuel A.
dc.date.accessioned2014-08-12T19:10:37Z
dc.date.available2014-08-12T19:10:37Z
dc.date.created2013-11-06
dc.date.issued2013
dc.description.abstractPrevious BAC clone analysis of the Platyrrhini owl monkey KIRs have shown an unusual genetic structure in some loci. Therefore, cDNAs encoding KIR molecules from eleven Aotus vociferans monkeys were characterized here; tenputative KIR loci were found, some of which encoded atypical proteins such as KIR4DL and transcripts predicted to encode a D0+D1 configuration (AOTVOKIR2DL1*01v1) which appear to be unique in the Aotus genus. Furthermore, alternative splicing was found as a likely mechanism for producing activator receptors in A. vociferans species. KIR proteins from New World monkeys may be split into three new lineages according to domain by domain phylogenetic analysis. Although the A. vociferans KIR family displayed a high divergence among paralogous genes, individual loci were limited in their genetic polymorphism. Selection analysis showed that both constrained and rapid evolution may operate within the AvKIR family. The frequent alternative splicing (as a likely mechanism generating activator receptors), the presence of KIR4DL and KIR2DL1 (D0+D1) molecules and other data reported here suggest that the KIR family in Aotus has had a rapid evolution, independent from its Catarrhini counterparts.from its Catarrhini counterparts.eng
dc.format.mediumRecurso electrónicospa
dc.format.mimetypeapplication/pdf
dc.format.tipoDocumentospa
dc.identifier.doihttps://doi.org/10.1371/journal.pone.0079731
dc.identifier.issn1932-6203
dc.identifier.urihttp://repository.urosario.edu.co/handle/10336/8816
dc.language.isoeng
dc.publisherUniversidad del Rosariospa
dc.relation.citationIssueNo. 11
dc.relation.citationTitlePLOS ONE
dc.relation.citationVolumeVol. 8
dc.relation.ispartofPLOS ONE, ISSN 1932-6203, V. 8 N. 11 Nov, 2013spa
dc.relation.urihttp://www.ncbi.nlm.nih.gov.ez.urosario.edu.co/pmc/articles/PMC3819253/pdf/pone.0079731.pdf
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto completo)spa
dc.rights.licenciaEL AUTOR, manifiesta que la obra objeto de la presente autorización es original y la realizó sin violar o usurpar derechos de autor de terceros, por lo tanto la obra es de exclusiva autoría y tiene la titularidad sobre la misma.spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.ddcEvolución & genética
dc.subject.decsAanálisis filogenéticospa
dc.subject.decsGenéticaspa
dc.subject.decsGenesspa
dc.subject.keywordAlternative splicingeng
dc.subject.keywordGenetic locieng
dc.subject.keywordGorillas; Monkeyseng
dc.subject.keywordPhylogenetic analysiseng
dc.subject.keywordPrimateseng
dc.subject.keywordProtein sequencingeng
dc.subject.keywordSequence alignmenteng
dc.titleIdentification and Diversity of Killer Cell Ig-Like Receptors in Aotus vociferans, a New World Monkeyspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/acceptedVersion
dc.type.spaArtículospa
Archivos
Bloque original
Mostrando1 - 1 de 1
Miniatura
Nombre:
Identification and Diversity.pdf
Tamaño:
3.56 MB
Formato:
Adobe Portable Document Format
Descripción:
Descargar
Colecciones
Artículos