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Caracterización del complejo mayor de histocompatibilidad clase II en primates del género Aotus

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dc.contributor.advisorCadavid Gutiérrez, Luis Fernando
dc.contributor.advisorPatarroyo, Manuel A.
dc.creatorSuarez Martinez, Carlos Fernando
dc.creator.degreeDoctor en Ciencias Biomédicas
dc.date.accessioned2017-10-11T13:59:03Z
dc.date.available2017-10-11T13:59:03Z
dc.date.created2017-10-05
dc.date.issued2017
dc.descriptionEl presente trabajo tiene como propósito contribuir al conocimiento del complejo mayor de histocompatibilidad clase II (CMH-II) de los monos Aotus, contribuyendo a la validación de este primate como modelo experimental, y aumentando el conocimiento en la evolución de los genes del CMH en primates. Además, se profundizó en el análisis de convergencia y polimorfismo de los genes del CMH-DR en primates. Se implementaron metodologías de modelación computacional de la unión CMH-péptido, como herramientas necesarias para entender los mecanismos de presentación de péptidos por parte del CMH clase II a los linfocitos T. El estudio del polimorfismo de la región de unión al péptido, permitió el desarrollo de estrategias para reducir eficientemente el número de sistemas a considerar en el diseño de péptidos a ser usados como candidatos a vacuna contra la malaria. Usando minería de datos sobre distribuciones de Ramachandran, se desarrolló una escala de similitud estructural de aminoácidos, con el fin de implementar su uso en el desarrollo de péptidos candidatos a vacunas. Adicionalmente, se encontró que la estructura secundaria de las proteínas tiene una relación clara con los patrones evolutivos de sustitución y la mutabilidad de los aminoácidos. Así, se ha generado un marco de conceptual que contribuye al desarrollo de vacunas basadas en péptidos, que tiene como base el estudio del polimorfismo del complejo mayor de histocompatibilidad, las restricciones fisicoquímicas/estructurales que moldean el proceso de reconocimiento molecular involucrado en la interacción CMH-péptido y la aplicación de metodologías computacionales para cuantificar el proceso de unión CMH-péptido.spa
dc.description.abstractThis work was aimed to contribute to increase our knowledge on the MHC class II in monkeys from the genus Aotus. Determining the sequences of MHC-DPA and MHC-DRA genes has allowed to complete the characterisation of the Aotus MHC, contributing towards validating the role of this primate as experimental model and increasing our knowledge regarding MHC gene evolution in primates. It also dealt with in–depth analysis of MHC-DR genes’ convergence and polymorphism in primates. The study involves computational modelling of MHC-peptide binding methodologies (based on quantum chemistry and neural networks) as necessary tools for understanding the mechanisms of MHC class II peptide presentation to T-lymphocytes. Studying peptide binding region polymorphism has enabled developing strategies (pocket profiles) for efficiently reducing the amount of systems to be considered when designing peptides to be used as candidates for an antimalarial vaccine. Data-mining regarding Ramachandran distribution led to developing an amino acid structural similarity scale for use in developing/designing peptides as vaccine candidates. It was found that protein secondary structure has a clear relationship with amino acid substitution and mutability evolutionary patterns. A conceptual framework thus emerged aimed at developing peptide-based vaccines as a basis for studying the mayor histocompatibility complex polymorphism, the physicochemical/structural restrictions shaping the molecular recognition involved in MHC-peptide interaction and using computational methodologies for quantifying MHC-peptide binding. eng
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dc.identifier.doihttps://doi.org/10.48713/10336_13809
dc.identifier.urihttp://repository.urosario.edu.co/handle/10336/13809
dc.language.isospa
dc.publisherUniversidad del Rosariospa
dc.publisher.departmentFacultad de Ciencias Naturales y Matemáticasspa
dc.publisher.programDoctorado en Ciencias Biomédicasspa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto completo)spa
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dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subjectComplejo mayor de histocompatibilidadspa
dc.subjectEvolución molecularspa
dc.subjectMonos del nuevo mundospa
dc.subjectPlatyrrhinispa
dc.subjectMicrosatélite D6S2878spa
dc.subjectConvergencia molecularspa
dc.subjectEstructura secundaria de proteínasspa
dc.subjectSustituciones de aminoácidosspa
dc.subjectMatrices de mutaciónspa
dc.subjectPrimatesspa
dc.subjectPM7spa
dc.subjectFMO-PIEDAspa
dc.subjectDFTBspa
dc.subjectInteracción proteína-proteínaspa
dc.subjectUnión CMH-péptidospa
dc.subject.ddcBiología
dc.subject.decsInmunologíaspa
dc.subject.decsHistocompatibilidadspa
dc.subject.decsPolimorfismo genéticospa
dc.subject.keywordMajor histocompatibility complexeng
dc.subject.keywordMolecular evolutioneng
dc.subject.keywordNew world monkeyseng
dc.subject.keywordPlatyrrhinieng
dc.subject.keywordD6S2878 microsatelliteeng
dc.subject.keywordMolecular convergenceeng
dc.subject.keywordMHC-peptide bindingeng
dc.subject.keywordProtein secondary structureeng
dc.subject.keywordSubstitution matriceseng
dc.subject.keywordPrimateseng
dc.subject.keywordPM7eng
dc.subject.keywordDFTBeng
dc.subject.keywordFMO-PIEDAeng
dc.subject.keywordprotein-protein interactioneng
dc.subject.lembInmunologíaspa
dc.titleCaracterización del complejo mayor de histocompatibilidad clase II en primates del género Aotusspa
dc.typedoctoralThesiseng
dc.type.hasVersioninfo:eu-repo/semantics/acceptedVersion
dc.type.spaTesis de doctoradospa
local.department.reportEscuela de Medicina y Ciencias de la Saludspa
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