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Protección miocárdica con custodiol y trastornos de la osmolalidad

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dc.contributor.advisorMontes Romero, Felix Ramon
dc.creatorValero Garzón, Wilmer
dc.creator.degreeEspecialista en Anestesia Cardiotorácica
dc.date.accessioned2015-08-10T16:26:57Z
dc.date.available2015-08-10T16:26:57Z
dc.date.created2015-08-05
dc.date.issued2015
dc.descriptionEn análisis retrospectivo evaluamos 91 pacientes llevados a cirugía cardiaca entre 2013 y 2014 en la Fundación Cardioinfantil, en quienes se administro Custodiol, analizando los niveles de sodio y osmolalidad plasmática efectiva antes, durante y después del procedimiento quirúrgico. Nosotros evaluamos la relación entre administración de Custodiol y cambios en el sodio y osmolalidad plasmática del paciente llevado a cirugía cardiaca.spa
dc.description.abstractIntroduction: Hyponatremia and osmolality disorders have been identified as independent predictors of increased morbidity, mortality and length of hospital stay in patients after cardiac surgery. Administration of Custodiol for myocardial protection may alter serum sodium levels and thereby alter the effective plasma osmolality. We evaluated the relationship between administration of Custodiol, and the fluctuation of sodium concentration and plasma osmolality in heart surgery patients. Methods: In this retrospective analysis we reviewed 91 patients who underwent cardiac surgery from 2013 to 2014 in the Fundación Cardioinfantil. Custodiol was administered to all patients. Sodium levels were analyzed and effective plasma osmolality was calculated before, during and after the surgical procedure. Results: All patients were normonatremic at start of surgery. 93.47% of patients developed hyponatremia after administering Custodiol with a significant decrease in mean serum sodium 12.43 mEq/l (P <0.001). Upon completion of the surgical procedure average effective plasma osmolality was 278.47 ± 8.11 mOsm/L (median=278) and the mean serum sodium was 135.35 ± 4.18 mEq / L (median=135). Presenting a significant difference before and after cardiopulmonary bypass (p<0.001, repeated measures ANOVA Friedman, CM). Conclusions: The use of Custodiol produces a significant decrease on the effective plasmatic osmolality and serum sodium. However the median of effective plasmatic osmolality and serum sodium are in normal range at the end of the cardiac surgery. It is not recommended as a routine to treat the hyponatremia caused by the use of Custodiol during the cardiopulmonary bypass.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.48713/10336_10700
dc.identifier.urihttp://repository.urosario.edu.co/handle/10336/10700
dc.language.isospa
dc.publisherUniversidad del Rosariospa
dc.publisher.departmentFacultad de Medicinaspa
dc.publisher.programEspecialización en Anestesia Cardiotorácicaspa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto completo)spa
dc.rights.licenciaEL AUTOR, manifiesta que la obra objeto de la presente autorización es original y la realizó sin violar o usurpar derechos de autor de terceros, por lo tanto la obra es de exclusiva autoría y tiene la titularidad sobre la misma. PARGRAFO: En caso de presentarse cualquier reclamación o acción por parte de un tercero en cuanto a los derechos de autor sobre la obra en cuestión, EL AUTOR, asumirá toda la responsabilidad, y saldrá en defensa de los derechos aquí autorizados; para todos los efectos la universidad actúa como un tercero de buena fe. EL AUTOR, autoriza a LA UNIVERSIDAD DEL ROSARIO, para que en los términos establecidos en la Ley 23 de 1982, Ley 44 de 1993, Decisión andina 351 de 1993, Decreto 460 de 1995 y demás normas generales sobre la materia, utilice y use la obra objeto de la presente autorización. -------------------------------------- POLITICA DE TRATAMIENTO DE DATOS PERSONALES. Declaro que autorizo previa y de forma informada el tratamiento de mis datos personales por parte de LA UNIVERSIDAD DEL ROSARIO para fines académicos y en aplicación de convenios con terceros o servicios conexos con actividades propias de la academia, con estricto cumplimiento de los principios de ley. Para el correcto ejercicio de mi derecho de habeas data cuento con la cuenta de correo habeasdata@urosario.edu.co, donde previa identificación podré solicitar la consulta, corrección y supresión de mis datos.spa
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dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subjectHiponatremiaspa
dc.subjectCustodiolspa
dc.subjectBypass cardiopulmonarspa
dc.subjectCirugía cardiacaspa
dc.subject.ddcVarias ramas de la medicina, Cirugía
dc.subject.decsCirugía torácicaspa
dc.subject.decsAnestésicosspa
dc.subject.keywordHyponatremiaeng
dc.subject.keywordCustodioleng
dc.subject.keywordCardiopulmonary bypasseng
dc.subject.keywordCardiac surgeryeng
dc.subject.lembAnestesiologíaspa
dc.subject.lembCirugía cardiacaspa
dc.subject.lembAnestesia en cardiologíaspa
dc.titleProtección miocárdica con custodiol y trastornos de la osmolalidadspa
dc.typemasterThesiseng
dc.type.hasVersioninfo:eu-repo/semantics/acceptedVersion
dc.type.spaTrabajo de gradospa
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