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Caracterización de manifestaciones endocrinológicas de pacientes pediátricos con tumores cerebrales en Clínica Infantil Colsubsidio entre 2008 - 2014

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dc.contributor.advisorBuendia, Richard
dc.contributor.advisorRoa Rodríguez, Sandra Maricela
dc.creatorReino Escobar, Adelaida Andrea
dc.creator.degreeEspecialista en Pediatría
dc.date.accessioned2017-07-17T18:06:21Z
dc.date.available2017-07-17T18:06:21Z
dc.date.created2017-07-10
dc.date.issued2017
dc.descriptionIntroducción Debido a nuevas terapias para el tratamiento del cáncer en niños, son más los sobrevivientes. Presentan frecuentemente efectos secundarios a agentes específicos. Los pacientes con tumores cerebrales, por las terapias dirigidas al sistema nervioso central, tienen mayor riesgo de presentar manifestaciones endocrinas que de no recibir un diagnóstico oportuno y manejo adecuado pueden aumentar la morbi-mortalidad en la evolución del paciente. Este estudio pretende caracterizar las manifestaciones endocrinas en sobrevivientes de tumores cerebrales, que acudieron a la consulta de endocrinología pediátrica en la Clínica Infantil Colsubsidio, Bogotá. Metodología Estudio descriptivo, retrospectivo de corte transversal. Se estableció la correlación entre el antecedente de tumor cerebral y alteraciones hormonales, que determinarían la presencia o no de manifestaciones endocrinas con otros factores asociados mediante un análisis multivariado. Resultados Se incluyeron 30 pacientes, 18 niñas (60%) y 12 niños (40%) y se encontró que de estos, 13 y 10 respectivamente, presentaron alguna manifestación endocrina. Algunos tumores cerebrales, no presentaron manifestación, otros una o varias manifestaciones endocrinas, las más frecuentes fueron baja talla, diabetes insípida, obesidad, hipotiroidismo central y pubertad precoz. Hubo valoración tardía por endocrinología pediátrica, después de la enfermedad 14.9 +/- 23,57 meses. Conclusión Los niños sobrevivientes a tumores cerebrales, pueden tener varias manifestaciones endocrinas. Se desconoce el momento exacto, en el cual presentaran alteraciones del eje hipotálamo-hipófisis por lo que deben tener un seguimiento multidisciplinario, guiado desde el punto de vista hormonal por el endocrinólogo pediatra, vigilando repercusiones sobre órganos endocrinos que pueden tener a su vez repercusiones sistémicas.spa
dc.description.abstractIntroductionBecause of new therapies for the treatment of cancer in children, more survivors. They often have side effects to specific agents. Patients with brain tumors, due to therapies directed to the central nervous system, are at increased risk of endocrine manifestations, which, if not promptly diagnosed and adequately managed, may increase morbidity and mortality in patient evolution. This study aims to characterize endocrine manifestations in survivors of brain tumors, who attended the pediatric endocrinology consultation at the Colsubsidio Children`s Clinic in Bogotá. MethodologyDescriptive, retrospective cross-sectional study. The correlation between the antecedent of brain tumor and hormonal alterations was established, which would determine the presence or not of endocrine manifestations with other associated factors through a multivariate analysis. ResultsWe included 30 patients, 18 girls (60%) and 12 children (40%), and found that of these, 13 and 10 respectively, presented some endocrine manifestation. Some brain tumors showed no manifestation, others one or more endocrine manifestations, the most frequent were low stature, diabetes insipidus, obesity, central hypothyroidism and precocious puberty. There was a late evaluation by pediatric endocrinology, after the disease 14. 9 +/- 23. 57 months. ConclusionChildren surviving brain tumors may have several endocrine manifestations. The exact moment in which they present alterations of the hypothalamus-pituitary axis is unknown, so they must have a multidisciplinary follow-up, guided from the hormonal point of view by the pediatric endocrinologist, monitoring repercussions on endocrine organs that may have systemic repercussions eng
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dc.identifier.doihttps://doi.org/10.48713/10336_13537
dc.identifier.urihttp://repository.urosario.edu.co/handle/10336/13537
dc.language.isospa
dc.publisherUniversidad del Rosariospa
dc.publisher.departmentFacultad de medicinaspa
dc.publisher.programEspecialización en Pediatríaspa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto completo)spa
dc.rights.ccAtribución-NoComercial-SinDerivadas 2.5 Colombiaspa
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dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subjectTumor cerebralspa
dc.subjectManifestación endocrinaspa
dc.subjectSobrevivientes al cáncerspa
dc.subjectNiñosspa
dc.subject.ddcEnfermedades
dc.subject.decsEndocrinologíaspa
dc.subject.decsNeoplasias encefálicasspa
dc.subject.decsHipopituitarismospa
dc.subject.decsHiperprolactinemiaspa
dc.subject.keywordBrain tumoreng
dc.subject.keywordEndocrine manifestationeng
dc.subject.keywordCancer survivorseng
dc.subject.keywordChildreneng
dc.subject.lembEndocrinologíaspa
dc.titleCaracterización de manifestaciones endocrinológicas de pacientes pediátricos con tumores cerebrales en Clínica Infantil Colsubsidio entre 2008 - 2014spa
dc.typemasterThesiseng
dc.type.hasVersioninfo:eu-repo/semantics/acceptedVersion
dc.type.spaTrabajo de gradospa
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