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Evaluación del desempeño diagnóstico de pruebas rápidas para Leishmaniasis Visceral

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dc.contributorAyala, Martha
dc.contributorFlórez, Carolina
dc.contributorCastillo, Adriana
dc.contributorCantillo, Omar
dc.contributor.advisorRamírez, Juan David
dc.contributor.advisorOlivera, Mario
dc.creatorHerrera Ossa, Giovanny Andrés
dc.creator.degreeMagíster en epidemiologíaspa
dc.creator.degreetypePart timespa
dc.date.accessioned2019-06-04T20:22:20Z
dc.date.available2019-06-04T20:22:20Z
dc.date.created2019-04-11
dc.date.issued2019
dc.descriptionLa Leishmaniasis Visceral (LV) es la forma mortal de las Leishmaniasis, la cual causa la muerte a más del 90% de los pacientes que la padecen. El diagnóstico de la LV se realiza a través de la observación directa del parásito lo que requiere procedimientos complejos restringiendo su uso a centros especializados. Las pruebas inmunocromatográficas (ICT) son una alternativa de fácil realización y permiten un diagnóstico presuntivo de la enfermedad, tanto en humanos como en caninos, los cuales desempeñan un papel fundamental en el circuito epidemiológico de transmisión. Sin embargo, se ha demostrado la variabilidad que pueden presentar las pruebas de acuerdo con la zona geográfica donde se aplican. Por lo anterior, este estudio evaluó el desempeño diagnóstico de 4 pruebas inmunocromatográficas para LV en sueros provenientes de humanos y caninos de zonas endémicas de Colombia. Se seleccionaron 82 sueros de humanos y 70 de caninos diagnosticados como positivos por Inmunofluorescencia Indirecta (IFI) y 74 sueros de humanos y 54 sueros de caninos diagnosticados como negativos. La sensibilidad (S) de las pruebas para humanos fue 91,5% y la especificidad estuvo entre 89,2 y 93,2%, mientras que las pruebas evaluadas en caninos mostraron valores de sensibilidad entre 82,9 y 85,7% y de especificidad entre 79.6 y 92,6%. Se concluye que las pruebas rápidas representan una herramienta de gran utilidad para la tamización de la LV, cuando se acompañan de un cuadro clínico sugestivo de la enfermedad. Se recomienda desarrollar pruebas rápidas basadas en las cepas del parásito circulantes en el país.spa
dc.description.embargo2021-06-05 01:01:01: Script de automatizacion de embargos. info:eu-repo/date/embargoEnd/2021-06-04
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dc.identifier.doihttps://doi.org/10.48713/10336_19826
dc.identifier.urihttp://repository.urosario.edu.co/handle/10336/19826
dc.language.isospa
dc.publisherUniversidad del Rosariospa
dc.publisher.departmentMaestría en Actividad Física y Saludspa
dc.publisher.otherUniversidad CESspa
dc.publisher.programMaestría en Epidemiologíaspa
dc.rightsAtribución-NoComercial-SinDerivadas 2.5 Colombiaspa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
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dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subjectPruebas rápidasspa
dc.subjectDesempeño diagnósticospa
dc.subject.ddcEnfermedadesspa
dc.subject.lembLeishmaniasis Visceralspa
dc.subject.lembMétodos rápidos (Microbiología)spa
dc.subject.lembDiagnósticospa
dc.titleEvaluación del desempeño diagnóstico de pruebas rápidas para Leishmaniasis Visceralspa
dc.typemasterThesiseng
dc.type.documentTesisspa
dc.type.hasVersioninfo:eu-repo/semantics/acceptedVersion
dc.type.spaTesis de maestríaspa
local.department.reportEscuela de Medicina y Ciencias de la Saludspa
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