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Soluciones hipertónicas en trauma craneoencefálico: revisión sistemática de la literatura

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dc.contributor.advisorVillabona Luna, Rafael
dc.creatorVitola Domínguez, Alexander
dc.creatorPerdomo, Andrés Mauricio
dc.creator.degreeEspecialista en Neurocirugía
dc.date.accessioned2014-08-12T13:49:19Z
dc.date.available2014-08-12T13:49:19Z
dc.date.created2014-06-06
dc.date.issued2014
dc.descriptionEl traumatismo craneoencefálico, es la epidemia silenciosa de nuestra época, que genera gastos en salud, en países como Estados Unidos, cercanos a los 60 billones de dólares anuales, y cerca de 400 billones en rehabilitación de los discapacitados. El pilar del manejo médico del trauma craneoencefálico moderado o severo, es la osmoterapia, principalmente con sustancias como el manitol y las soluciones hipertónicas. Se realizó la revisión de 14 bases de datos, encontrando 4657754 artículos, quedando al final 40 artículos después de un análisis exhaustivo, que se relacionaban con el manejo de la hipertensión endocraneana y terapia osmótica. Resultados: Se compararon diferentes estudios, encontrando gran variabilidad estos, sin homogenización en los análisis estadísticos, y la poca rigurosidad no permitieron, la recolección de datos y la comparación entre los diferentes estudios, no permitió realizar el meta-análisis y por esto se decidió la realización de una revisión sistemática de la literatura. Se evidenció principalmente tres cosas: la primera es la poca rigurosidad con la que se realizan los estudios clínicos; la segunda, es que aún falta mucha más investigación principalmente, la presencia de estudios clínicos aleatorizados multicéntricos, que logren dar una sólida evidencia y que genere validez científica que se requiere, a pesar de la evidencia clara en la práctica clínica; la tercera es la seguridad para su uso, con poca presencia de complicaciones para las soluciones salinas hipertónicas.spa
dc.description.abstractTraumatic Brain Injury is the silent epidemic disease actually, and generates spent of health costs about 60 billion dollars per year, and almost 400 billion dollars in rehabilitation in survivors. The cornerstone, in the treatment of moderate and severe traumatic brain injury, is the Osmotherapy, mainly with substances like Mannitol and Hypertonic Solutions. It was made the research of 14 databases, finding 4657754 articles, leaving 40 trials after an exhaustive analysis, that they were related with intracranial hypertension and osmotic therapy. Comparing the different articles, it was found a great variability in the type of trials without homogenization about statistical analysis, and the lack of stringency, that not allowed the meta-analysis, so the realization of a systematic review of the literature was decided. It was evidenced three things mainly: first, is the lack of stringency how the clinical trials were made; second, it was the deficiency of multicentric random clinical trials, that could give the solid evidence and scientific validity is required, despite the clear evidence in clinical practice; the third is the security for their use with low presence of complications for hypertonic saline solutions.eng
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dc.identifier.doihttps://doi.org/10.48713/10336_8787
dc.identifier.urihttp://repository.urosario.edu.co/handle/10336/8787
dc.language.isospa
dc.publisherUniversidad del Rosariospa
dc.publisher.departmentFacultad de Medicinaspa
dc.publisher.programEspecialización en Neurologíaspa
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dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subjectTrauma Craneoencefálicospa
dc.subjectEdema Cerebralspa
dc.subjectOsmoterapiaspa
dc.subjectTerapia Osmóticaspa
dc.subjectSalina Hipertónicaspa
dc.subjectSoluciones Hipertónicasspa
dc.subjectSoluciones Salinas Hipertónicasspa
dc.subjectManitol.spa
dc.subject.ddcCiencias médicas, Medicina
dc.subject.decsTrauma Craneoencefálicospa
dc.subject.decsEdema Cerebralspa
dc.subject.decsTerapia osmóticaspa
dc.subject.decsSoluciones hipertónicasspa
dc.subject.keywordTraumatic Brain Injuryeng
dc.subject.keywordBrain Edemaeng
dc.subject.keywordOsmotherapyeng
dc.subject.keywordOsmotic Therapyeng
dc.subject.keywordHypertonic Salineeng
dc.subject.keywordHypertonic Solutionseng
dc.subject.keywordHypertonic Saline Solutionseng
dc.subject.keywordMannitol.eng
dc.titleSoluciones hipertónicas en trauma craneoencefálico: revisión sistemática de la literaturaspa
dc.typemasterThesiseng
dc.type.hasVersioninfo:eu-repo/semantics/acceptedVersion
dc.type.spaTrabajo de gradospa
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