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Distribution patterns of infection with multiple types of human papillomaviruses and their association with risk factors

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dc.audienceComunidad Rosaristaspa
dc.creatorSoto De Leon, Sara C
dc.creatorCamargo, Milena
dc.creatorSánchez, Ricardo
dc.creatorMunoz, Marina
dc.creatorPerez-Prados, Antonio
dc.creatorPurroy, Antonio
dc.creatorPatarroyo, Manuel E.
dc.creatorPatarroyo, Manuel A.
dc.creator.googleSoto-De Leon, Sara
dc.creator.googleCamargo, Milena
dc.creator.googleSanchez, Ricardo
dc.creator.googleMuñoz, Marina
dc.creator.googlePerez-Prados, Antonio
dc.creator.googlePurroy, Antonio
dc.creator.googlePatarroyo, Manuel Elkin
dc.creator.googlePatarroyo, Manuel Alfonso
dc.date.accessioned2014-08-13T19:41:08Z
dc.date.available2014-08-13T19:41:08Z
dc.date.created2011-02-17
dc.date.issued2011
dc.description.abstractBackground: Infection with multiple types of human papillomavirus (HPV) is one of the main risk factors associated with the development of cervical lesions. In this study, cervical samples collected from 1,810 women with diverse sociocultural backgrounds, who attended to their cervical screening program in different geographical regions of Colombia, were examined for the presence of cervical lesions and HPV by Papanicolau testing and DNA PCR detection, respectively. Principal Findings: The negative binomial distribution model used in this study showed differences between the observed and expected values within some risk factor categories analyzed. Particularly in the case of single infection and coinfection with more than 4 HPV types, observed frequencies were smaller than expected, while the number of women infected with 2 to 4 viral types were higher than expected. Data analysis according to a negative binomial regression showed an increase in the risk of acquiring more HPV types in women who were of indigenous ethnicity (+37.8%), while this risk decreased in women who had given birth more than 4 times (-31.1%), or were of mestizo (-24.6%) or black (-40.9%) ethnicity. Conclusions: According to a theoretical probability distribution, the observed number of women having either a single infection or more than 4 viral types was smaller than expected, while for those infected with 2-4 HPV types it was larger than expected. Taking into account that this study showed a higher HPV coinfection rate in the indigenous ethnicity, the role of underlying factors should be assessed in detail in future studies.eng
dc.format.mediumRecurso electrónicospa
dc.format.mimetypeapplication/pdf
dc.format.tipoDocumentospa
dc.identifier.doihttps://doi.org/10.1371/journal.pone.0014705
dc.identifier.issn1932-6203
dc.identifier.urihttp://repository.urosario.edu.co/handle/10336/8840
dc.language.isoeng
dc.publisherUniversidad del Rosariospa
dc.relation.citationIssueNo. 2
dc.relation.citationTitlePLOS ONE
dc.relation.citationVolumeVol. 6
dc.relation.ispartofPLOS ONE ISSN: 1932-6203 V. 6 N. 2 Feb 17, 2011spa
dc.relation.urihttp://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0014705
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto completo)spa
dc.rights.licenciaEL AUTOR, manifiesta que la obra objeto de la presente autorización es original y la realizó sin violar o usurpar derechos de autor de terceros, por lo tanto la obra es de exclusiva autoría y tiene la titularidad sobre la misma.spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.ddcEnfermedades
dc.subject.decsSíndrome de Inmunodeficiencia Adquirida. SIDAspa
dc.subject.decsVirus del papiloma humano. VPHspa
dc.subject.decsEnfermedades infecciosasspa
dc.subject.decsEnfermedades autoinmunesspa
dc.subject.keywordInvasive carvical -cancereng
dc.subject.keywordHPV infectioneng
dc.subject.keywordGenetic susceptiblityeng
dc.subject.keywordUnversity-studentseng
dc.subject.keywordAfrican -americaneng
dc.subject.keywordPCR detectioneng
dc.subject.keywordPrimer setseng
dc.subject.keywordWomeneng
dc.subject.keywordEpidemiologyeng
dc.subject.keywordPrevalenceeng
dc.titleDistribution patterns of infection with multiple types of human papillomaviruses and their association with risk factorsspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/acceptedVersion
dc.type.spaArtículospa
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