Ítem
Acceso Abierto

Infección por virus sincitial respiratorio y su relación con valores de IGG en niños críticos

Mostrar el registro sencillo de la publicación
dc.contributor.advisorRuiz, Diana Alejandra
dc.creatorBonilla González, Carolina
dc.creator.degreeEspecialista en Cuidado Intensivo Pediátrico
dc.date.accessioned2016-08-30T21:16:37Z
dc.date.available2016-08-30T21:16:37Z
dc.date.created2016-08-02
dc.date.issued2016
dc.descriptionAntecedente: La infección por el virus sincitial respiratorio (VSR) representa una elevada morbimortalidad, y en algunos casos necesidad de manejo en unidades de cuidado intensivo pediátrico (UCIP). La respuesta inmunológica influye de manera directa en la expresión de la severidad y pronóstico de los pacientes con infección respiratoria. Metodología: Estudio de una cohorte retrospectiva de pacientes con infección respiratoria grave secundaria a VSR, sin historia de inmunodeficiencia, atendidos en la UCIP del Hospital Universitario Clínica San Rafael. Se realizó análisis descriptivoglobaly de acuerdo a la categorización de las prueba de IgG. Resultados: De 188 pacientes que ingresaron a la UCIP, 13% presentaron infección por VSR (24), con una edad promedio de 7,3 (DE=3,6) meses. Pertenecían al sexo masculino79,83%. Se encontró que 12,5% tenían un valor de IgGbajo para su edad, 58,33% tenían valores en límite inferior y el 29,17% dentro de rangos normales para su edad. En los pacientes con IgG baja, fue mayor la presentación de choque séptico que no responde a líquidos (100 vs 92 vs 86%), la mediana de días de ventilación mecánica fue mayor (8 vs 6 vs 5 respectivamente), así como la mortalidad (67 vs 7,1 vs 0%). Conclusión: Nuestra serie encontró que aquellos pacientes con niveles bajos o valores en el límite inferior de IgG sérica tuvieron mayor compromiso sistémico, mayor duración de ventilación mecánica y mayor mortalidad. Se necesitan estudios prospectivos que relaciones niveles bajos de IgG con severidad y pronostico en estos pacientes con infección grave por VSR.spa
dc.description.abstractBackground: Respiratory Syncytial Virus (RSV) infection represents a high morbidity and mortality, and in some cases management in pediatric intensive care units (PICU). The immune response directly influences the severity and prognosis of patients with respiratory infection. Methodology: A retrospective study of a cohort of patients with severe RSV respiratory infection and no history of immunodeficiency was conducted in the PICU of San Rafael University Hospital Clinic. Global descriptive analysis was performed and according to the categorization of IgG tests analysis. Results: Of 188 patients admitted to the PICU, 13% had RSV infection (24), with an average age of 7. 3 (SD = 3. 6) months; 79. 83% were male. Twelve point five percent had a low value of IgG, 58. 33% had a lower limit value and 29. 17% within the normal range for their age. In patients with low IgG was higher septic shock unresponsive to liquids (100 vs 92 vs 86%), median days of mechanical ventilation (8 vs 6 vs 5, respectively) and mortality (67 vs 7. 1 vs 0%). Conclusion: Our series found that patients with low levels or lower limit values of IgG had more systemic involvement, longer duration of mechanical ventilation and increased mortality. Prospective studies are needed that low levels of IgG relationships with severity and prognosis for these patients with severe RSV infection. eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.48713/10336_12322
dc.identifier.urihttp://repository.urosario.edu.co/handle/10336/12322
dc.language.isospa
dc.publisherUniversidad del Rosariospa
dc.publisher.departmentFacultad de medicinaspa
dc.publisher.programEspecialización en Cuidado Intensivo Pediátricospa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto completo)spa
dc.rights.ccAtribución-NoComercial-SinDerivadas 2.5 Colombiaspa
dc.rights.licenciaEL AUTOR, manifiesta que la obra objeto de la presente autorización es original y la realizó sin violar o usurpar derechos de autor de terceros, por lo tanto la obra es de exclusiva autoría y tiene la titularidad sobre la misma. PARGRAFO: En caso de presentarse cualquier reclamación o acción por parte de un tercero en cuanto a los derechos de autor sobre la obra en cuestión, EL AUTOR, asumirá toda la responsabilidad, y saldrá en defensa de los derechos aquí autorizados; para todos los efectos la universidad actúa como un tercero de buena fe. EL AUTOR, autoriza a LA UNIVERSIDAD DEL ROSARIO, para que en los términos establecidos en la Ley 23 de 1982, Ley 44 de 1993, Decisión andina 351 de 1993, Decreto 460 de 1995 y demás normas generales sobre la materia, utilice y use la obra objeto de la presente autorización. -------------------------------------- POLITICA DE TRATAMIENTO DE DATOS PERSONALES. Declaro que autorizo previa y de forma informada el tratamiento de mis datos personales por parte de LA UNIVERSIDAD DEL ROSARIO para fines académicos y en aplicación de convenios con terceros o servicios conexos con actividades propias de la academia, con estricto cumplimiento de los principios de ley. Para el correcto ejercicio de mi derecho de habeas data cuento con la cuenta de correo habeasdata@urosario.edu.co, donde previa identificación podré solicitar la consulta, corrección y supresión de mis datos.spa
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/2.5/co/
dc.source.bibliographicCitation1. Secretaría Distrital de Salud de Bogotá. Boletin II trimestre de 2014. Boletin enfermedad respiratoria aguda ERA [Internet]. 2014. [CItado 5 de julio de 2016]. Disponible en:http://www.saludcapital.gov.co/DSP/ERA/Bolet%C3%ADn%20ERA%20II%20Trimest re%202014.pdf
dc.source.bibliographicCitation2. Casto J RD. Caracterizaciòn del Virus Sincitial Respiratorio en la Unidad de Cuidados Intensivos Pediàtricos del Hospital Universitario Clìnica San Rafael de Bogotà en el Periodo de enero 1 a junio 30 de los años 2010 y 2011: Universidad Militar Nueva Granada 2012.
dc.source.bibliographicCitation3. K. M. Developments in respiratory syncytial virus (RSV) I: pathogenesis. Medwave. 2008;8(9):1713.
dc.source.bibliographicCitation4. Walsh EE, Peterson DR, Falsey AR. Risk factors for severe respiratory syncytial virus infection in elderly persons. J Infect Dis. 2004;189(2):233-8.
dc.source.bibliographicCitation5. Fields BN, Knipe DM, Howley PM. Paramyxoviridae: Respiratory Syncytial Virus and Metapneumovirus. Fields' Virology. II: Wolters Kluwer Health/Lippincott Williams & Wilkins; 2007. p. 3177.
dc.source.bibliographicCitation6. Johnson PR, Spriggs MK, Olmsted RA, Collins PL. The G glycoprotein of human respiratory syncytial viruses of subgroups A and B: extensive sequence divergence between antigenically related proteins. Proc Natl Acad Sci U S A. 1987;84(16):5625-9.
dc.source.bibliographicCitation7. Murphy BR. WR. Orthomyxoviruses. In: Knippe DM HP, editor. Fields BN. 3 ed. Nueva York: Lippincot-Raven 1996. p. 1397.
dc.source.bibliographicCitation8. Eiros JM, Ortiz de Lejarazu R, Tenorio A, Casas I, Pozo F, Ruiz G, et al. [Microbiological diagnosis of viral respiratory infections]. Enferm Infecc Microbiol Clin. 2009;27(3):168-77.
dc.source.bibliographicCitation9. Yamaguchi M, Sano Y, Dapat IC, Saito R, Suzuki Y, Kumaki A, et al. High frequency of repeated infections due to emerging genotypes of human respiratory syncytial viruses among children during eight successive epidemic seasons in Japan. J Clin Microbiol. 2011;49(3):1034-40.
dc.source.bibliographicCitation10. Hall CB, Weinberg GA, Iwane MK, Blumkin AK, Edwards KM, Staat MA, et al. The burden of respiratory syncytial virus infection in young children. N Engl J Med. 2009;360(6):588-98.
dc.source.bibliographicCitation11. Shay DK, Holman RC, Newman RD, Liu LL, Stout JW, Anderson LJ. Bronchiolitis-associated hospitalizations among US children, 1980-1996. JAMA. 1999;282(15):1440-6.
dc.source.bibliographicCitation12. Stockman LJ, Curns AT, Anderson LJ, Fischer-Langley G. Respiratory syncytial virus-associated hospitalizations among infants and young children in the United States, 1997-2006. Pediatr Infect Dis J. 2012;31(1):5-9.
dc.source.bibliographicCitation13. Nair H, Nokes DJ, Gessner BD, Dherani M, Madhi SA, Singleton RJ, et al. Global burden of acute lower respiratory infections due to respiratory syncytial virus in young children: a systematic review and meta-analysis. Lancet. 2010;375(9725):1545-55.
dc.source.bibliographicCitation14. Lozano R, Naghavi M, Foreman K, Lim S, Shibuya K, Aboyans V, et al. Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet. 2012;380(9859):2095-128.
dc.source.bibliographicCitation15. Moylett EH. PP. Respiratory syncytial virus infection: diagnosis, treatment and prevention. Hosp Med. 1999;35:10-7.
dc.source.bibliographicCitation16. Centers for Disease C, Prevention. Respiratory syncytial virus activity--United States, 1999-2000 season. MMWR Morb Mortal Wkly Rep. 2000;49(48):1091-3.
dc.source.bibliographicCitation17. Staat MA, Henrickson K, Elhefni H, Groothuis J, Makari D. Prevalence of respiratory syncytial virus-associated lower respiratory infection and apnea in infants presenting to the emergency department. Pediatr Infect Dis J. 2013;32(8):911-4.
dc.source.bibliographicCitation18. Johnson JE, Gonzales RA, Olson SJ, Wright PF, Graham BS. The histopathology of fatal untreated human respiratory syncytial virus infection. Mod Pathol. 2007;20(1):108-19.
dc.source.bibliographicCitation19. Hoffman SJ, Laham FR, Polack FP. Mechanisms of illness during respiratory syncytial virus infection: the lungs, the virus and the immune response. Microbes Infect. 2004;6(8):767-72.
dc.source.bibliographicCitation20. Everard ML, Swarbrick A, Wrightham M, McIntyre J, Dunkley C, James PD, et al. Analysis of cells obtained by bronchial lavage of infants with respiratory syncytial virus infection. Arch Dis Child. 1994;71(5):428-32.
dc.source.bibliographicCitation21. Fishaut M, Tubergen D, McIntosh K. Cellular response to respiratory viruses with particular reference to children with disorders of cell-mediated immunity. J Pediatr. 1980;96(2):179-86.
dc.source.bibliographicCitation22. Rohwedder A, Keminer O, Forster J, Schneider K, Schneider E, Werchau H. Detection of respiratory syncytial virus RNA in blood of neonates by polymerase chain reaction. J Med Virol. 1998;54(4):320-7.
dc.source.bibliographicCitation23. Welliver RC, Garofalo RP, Ogra PL. Beta-chemokines, but neither T helper type 1 nor T helper type 2 cytokines, correlate with severity of illness during respiratory syncytial virus infection. Pediatr Infect Dis J. 2002;21(5):457-61.
dc.source.bibliographicCitation24. Agarwal S, Cunningham-Rundles C. Assessment and clinical interpretation of reduced IgG values. Ann Allergy Asthma Immunol. 2007;99(3):281-3.
dc.source.bibliographicCitation25. Fisher RG, Gruber WC, Edwards KM, Reed GW, Tollefson SJ, Thompson JM, et al. Twenty years of outpatient respiratory syncytial virus infection: a framework for vaccine efficacy trials. Pediatrics. 1997;99(2):E7.
dc.source.bibliographicCitation26. Jolliff CR, Cost KM, Stivrins PC, Grossman PP, Nolte CR, Franco SM, et al. Reference intervals for serum IgG, IgA, IgM, C3, and C4 as determined by rate nephelometry. Clin Chem. 1982;28(1):126-8.
dc.source.bibliographicCitation27. El Saleeby CM, Suzich J, Conley ME, DeVincenzo JP. Quantitative effects of palivizumab and donor-derived T cells on chronic respiratory syncytial virus infection, lung disease, and fusion glycoprotein amino acid sequences in a patient before and after bone marrow transplantation. Clin Infect Dis. 2004;39(2):e17-20
dc.source.bibliographicCitation28. Stagliano DR, Nylund CM, Eide MB, Eberly MD. Children with Down syndrome are high-risk for severe respiratory syncytial virus disease. J Pediatr. 2015;166(3):703-9 e2.
dc.source.bibliographicCitation29. Hoebee B, Rietveld E, Bont L, Oosten M, Hodemaekers HM, Nagelkerke NJ, et al. Association of severe respiratory syncytial virus bronchiolitis with interleukin-4 and interleukin-4 receptor alpha polymorphisms. J Infect Dis. 2003;187(1):2-11.
dc.source.bibliographicCitation30. Puthothu B, Krueger M, Forster J, Heinzmann A. Association between severe respiratory syncytial virus infection and IL13/IL4 haplotypes. J Infect Dis. 2006;193(3):438-41.
dc.source.bibliographicCitation31. Lofgren J, Ramet M, Renko M, Marttila R, Hallman M. Association between surfactant protein A gene locus and severe respiratory syncytial virus infection in infants. J Infect Dis. 2002;185(3):283-9.
dc.source.bibliographicCitation32. Tal G, Mandelberg A, Dalal I, Cesar K, Somekh E, Tal A, et al. Association between common Toll-like receptor 4 mutations and severe respiratory syncytial virus disease. J Infect Dis. 2004;189(11):2057-63.
dc.source.bibliographicCitation33. Amanatidou V, Sourvinos G, Apostolakis S, Tsilimigaki A, Spandidos DA. T280M variation of the CX3C receptor gene is associated with increased risk for severe respiratory syncytial virus bronchiolitis. Pediatr Infect Dis J. 2006;25(5):410-4.
dc.source.bibliographicCitation34. Henderson FW, Collier AM, Clyde WA, Jr., Denny FW. Respiratory-syncytial-virus infections, reinfections and immunity. A prospective, longitudinal study in young children. N Engl J Med. 1979;300(10):530-4.
dc.source.bibliographicCitation35. Glezen WP, Paredes A, Allison JE, Taber LH, Frank AL. Risk of respiratory syncytial virus infection for infants from low-income families in relationship to age, sex, ethnic group, and maternal antibody level. J Pediatr. 1981;98(5):708-15.
dc.source.bibliographicCitation36. Stensballe LG, Ravn H, Kristensen K, Meakins T, Aaby P, Simoes EA. Seasonal variation of maternally derived respiratory syncytial virus antibodies and association with infant hospitalizations for respiratory syncytial virus. J Pediatr. 2009;154(2):296-8.
dc.source.bibliographicCitation37. Glezen WP, Taber LH, Frank AL, Kasel JA. Risk of primary infection and reinfection with respiratory syncytial virus. Am J Dis Child. 1986;140(6):543-6.
dc.source.bibliographicCitation38. Hall CB, Long CE, Schnabel KC. Respiratory syncytial virus infections in previously healthy working adults. Clin Infect Dis. 2001;33(6):792-6.
dc.source.bibliographicCitation39. Lindgren C, Jing L, Graham B, Grogaard J, Sundell H. Respiratory syncytial virus infection reinforces reflex apnea in young lambs. Pediatr Res. 1992;31(4 Pt 1):381-5.
dc.source.bibliographicCitation40. Uren EC, Williams AL, Jack I, Rees JW. Association of respiratory virus infections with sudden infant death syndrome. Med J Aust. 1980;1(9):417-9.
dc.source.bibliographicCitation41. Levine DA, Platt SL, Dayan PS, Macias CG, Zorc JJ, Krief W, et al. Risk of serious bacterial infection in young febrile infants with respiratory syncytial virus infections. Pediatrics. 2004;113(6):1728-34.
dc.source.bibliographicCitation42. Stein RT, Sherrill D, Morgan WJ, Holberg CJ, Halonen M, Taussig LM, et al. Respiratory syncytial virus in early life and risk of wheeze and allergy by age 13 years. Lancet. 1999;354(9178):541-5.
dc.source.bibliographicCitation43. Regnier SA, Huels J. Association between respiratory syncytial virus hospitalizations in infants and respiratory sequelae: systematic review and meta-analysis. Pediatr Infect Dis J. 2013;32(8):820-6.
dc.source.bibliographicCitation44. Backman K, Piippo-Savolainen E, Ollikainen H, Koskela H, Korppi M. Adults face increased asthma risk after infant RSV bronchiolitis and reduced respiratory health-related quality of life after RSV pneumonia. Acta Paediatr. 2014;103(8):850-5.
dc.source.bibliographicCitation45. Welliver RC. Review of epidemiology and clinical risk factors for severe respiratory syncytial virus (RSV) infection. J Pediatr. 2003;143(5 Suppl):S112-7.
dc.source.bibliographicCitation46. Giubergia V, Martinchuk G, Moreno N, Colombres G, Parra L, Viale D, et al. Gravedad de la infección por virus sincicial respiratorio en pacientes con factores de riesgo y sin ellos. Archivos argentinos de pediatría. 2004;102:330-4.
dc.source.bibliographicCitation47. Fodha I, Vabret A, Ghedira L, Seboui H, Chouchane S, Dewar J, et al. Respiratory syncytial virus infections in hospitalized infants: association between viral load, virus subgroup, and disease severity. J Med Virol. 2007;79(12):1951-8.
dc.source.bibliographicCitation48. Palomino M. LM, Moraga J., Avendaño L., Luis F. Severidad clinica de la infecciòn respiratoria aguda baja primaria por virus respiratorio sincicial grupos A y B Rev chil pediatr [Internet]. 2004 feb 2016; 75:[18-24 pp.].
dc.source.bibliographicCitation49. Zhang Y, Yuan L, Zhang Y, Zhang X, Zheng M, Kyaw MH. Burden of respiratory syncytial virus infections in China: Systematic review and meta-analysis. J Glob Health. 2015;5(2):020417.
dc.source.bibliographicCitation50. Kho N, Kerrigan JF, Tong T, Browne R, Knilans J. Respiratory syncytial virus infection and neurologic abnormalities: retrospective cohort study. J Child Neurol. 2004;19(11):859-64.
dc.source.bibliographicCitation51. Sweetman LL, Ng YT, Butler IJ, Bodensteiner JB. Neurologic complications associated with respiratory syncytial virus. Pediatr Neurol. 2005;32(5):307-10.
dc.source.bibliographicCitation52. Hirayama K, Sakazaki H, Murakami S, Yonezawa S, Fujimoto K, Seto T, et al. Sequential MRI, SPECT and PET in respiratory syncytial virus encephalitis. Pediatr Radiol. 1999;29(4):282-6.
dc.source.bibliographicCitation53. Hanna S, Tibby SM, Durward A, Murdoch IA. Incidence of hyponatraemia and hyponatraemic seizures in severe respiratory syncytial virus bronchiolitis. Acta Paediatr. 2003;92(4):430-4.
dc.source.bibliographicCitation54. van Steensel-Moll HA, Hazelzet JA, van der Voort E, Neijens HJ, Hackeng WH. Excessive secretion of antidiuretic hormone in infections with respiratory syncytial virus. Arch Dis Child. 1990;65(11):1237-9.
dc.source.bibliographicCitation55. Tasker RC, Roe MF, Bloxham DM, White DK, Ross-Russell RI, O'Donnell DR. The neuroendocrine stress response and severity of acute respiratory syncytial virus bronchiolitis in infancy. Intensive Care Med. 2004;30(12):2257-62.
dc.source.bibliographicCitation56. Fujishima H, Okamoto Y, Saito I, Tsubota K. Respiratory syncytial virus and allergic conjunctivitis. J Allergy Clin Immunol. 1995;95(3):663-7.
dc.source.bibliographicCitation57. Englund JA, Piedra PA, Jewell A, Patel K, Baxter BB, Whimbey E. Rapid diagnosis of respiratory syncytial virus infections in immunocompromised adults. J Clin Microbiol. 1996;34(7):1649-53.
dc.source.bibliographicCitation58. Chartrand C, Tremblay N, Renaud C, Papenburg J. Diagnostic Accuracy of Rapid Antigen Detection Tests for Respiratory Syncytial Virus Infection: Systematic Review and Meta-analysis. J Clin Microbiol. 2015;53(12):3738-49.
dc.source.bibliographicCitation59. Puppe W, Weigl JA, Aron G, Grondahl B, Schmitt HJ, Niesters HG, et al. Evaluation of a multiplex reverse transcriptase PCR ELISA for the detection of nine respiratory tract pathogens. J Clin Virol. 2004;30(2):165-74.
dc.source.bibliographicCitation60. Willson DF, Jiao JH, Hendley JO, Donowitz L. Invasive monitoring in infants with respiratory syncytial virus infection. J Pediatr. 1996;128(3):357-62.
dc.source.bibliographicCitation61. Hall CB. Respiratory syncytial virus and parainfluenza virus. N Engl J Med. 2001;344(25):1917-28.
dc.source.bibliographicCitation62. Eisenhut M. Extrapulmonary manifestations of severe respiratory syncytial virus infection--a systematic review. Crit Care. 2006;10(4):R107.
dc.source.bibliographicCitation63. Reyes MA, Duque GA, Quevedo FL. Neumología Pediátrica. Infección, alergia y enfermedad respiratoria en el niño: Editorial Medica Panamericana Sa de; 2006.
dc.source.bibliographicCitation64. Salud OMdl. Plan de acciòn estratègico de la OMS para la gripe pandèmica. Ginebra2006.
dc.source.bibliographicCitation65. Nair H, Nokes DJ, Gessner BD, Dherani M, Madhi SA, Singleton RJ, et al. Global burden of acute lower respiratory infections due to respiratory syncytial virus in young children: a systematic review and meta-analysis. The Lancet. 2010;375(9725):1545-55.
dc.source.bibliographicCitation66. Buckingham SC, Quasney MW, Bush AJ, DeVincenzo JP. Respiratory syncytial virus infections in the pediatric intensive care unit: clinical characteristics and risk factors for adverse outcomes. Pediatric Critical Care Medicine. 2001;2(4):318-23.
dc.source.bibliographicCitation67. Straliotto SM, Siqueira MM, Machado V, Maia TMR. Respiratory viruses in the pediatric intensive care unit: prevalence and clinical aspects. Memórias do Instituto Oswaldo Cruz. 2004;99(8):883-7.
dc.source.bibliographicCitation68. Bello O, Langenhin M, Pujadas M, Mateo S, Chiparelli H. Infecciones graves por virus respiratorio sincicial en lactantes menores de tres meses: Incidencia en pacientes sin factores de riesgo clásicos. Archivos de Pediatría del Uruguay. 2001;72:S20-S5.
dc.source.bibliographicCitation69. Herrera-Rodríguez DH, De la Hoz F, Mariño C, Ramírez E. Virus Respiratorios en Menores de Diez Años con Infección Respiratoria en el Hospital Militar Central de Bogotá. Revista de Salud Pública. 2007;9(4):576-86.
dc.source.bibliographicCitation70. Welliver Sr RC. Temperature, humidity, and ultraviolet B radiation predict community respiratory syncytial virus activity. The Pediatric infectious disease journal. 2007;26(11):S29-S35.
dc.source.bibliographicCitation71. Secretaría Distrital de Salud de Bogotá. Boletín informativo distrital de impactos en la salud de los eventos climáticos extremos asociados a variabilidad climática. Bogotá, Colombia. [Internet]. 2015. [Citado 30 de junio de 2015]; 66:1-11 . Disponible en:http://biblioteca.saludcapital.gov.co/img_upload/57c59a889ca266ee6533c26f970cb14a/ Boletin Abr_15.pdf.
dc.source.bibliographicCitation72. Arruvito L, Raiden S, Geffner J. Host response to respiratory syncytial virus infection. Current opinion in infectious diseases. 2015;28(3):259-66.
dc.source.bibliographicCitation73. Lacroix-Desmazes S, Bayry J, Kaveri SV, Hayon-Sonsino D, Thorenoor N, Charpentier J, et al. High levels of catalytic antibodies correlate with favorable outcome in sepsis. Proceedings of the National Academy of Sciences of the United States of America. 2005;102(11):4109-13.
dc.source.bibliographicCitation74. Bermejo‐Martín JF, Rodriguez‐Fernandez A, Herrán‐Monge R, Andaluz‐Ojeda D, Muriel‐Bombín A, Merino P, et al. Immunoglobulins IgG1, IgM and IgA: a synergistic team influencing survival in sepsis. Journal of internal medicine. 2014;276(4):404-12.
dc.source.bibliographicCitation75. Andaluz-Ojeda D, Iglesias V, Bobillo F, Almansa R, Rico L, Gandía F, et al. Early natural killer cell counts in blood predict mortality in severe sepsis. Crit Care. 2011;15(5):R243.
dc.source.bibliographicCitation76. Tamayo E, Fernández A, Almansa R, Carrasco E, Goncalves L, Heredia M, et al. Beneficial role of endogenous immunoglobulin subclasses and isotypes in septic shock. Journal of critical care. 2012;27(6):616-22.
dc.source.bibliographicCitation77. Taccone FS, Stordeur P, De Backer D, Creteur J, Vincent J-L. γ-globulin levels in patients with community-acquired septic shock. Shock. 2009;32(4):379-85.
dc.source.bibliographicCitation78. Venet F, Gebeile R, Bancel J, Guignant C, Poitevin-Later F, Malcus C, et al. Assessment of plasmatic immunoglobulin G, A and M levels in septic shock patients. International immunopharmacology. 2011;11(12):2086-90.
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subjectVirus sincitial respiratoriospa
dc.subjectinmunoglobulinasspa
dc.subjectinmunodeficienciaspa
dc.subjecthipogamaglobulineamiaspa
dc.subjectunidad de cuidado intensivo pediátricospa
dc.subject.ddcEnfermedades
dc.subject.decsPediatríaspa
dc.subject.decsCuidados críticosspa
dc.subject.decsEnfermedades respiratoriasspa
dc.subject.keywordRespiratory Syncytial Viruseng
dc.subject.keywordimmunoglobulinseng
dc.subject.keywordimmunodeficiencyeng
dc.subject.keywordhipogamaglobulineamiaeng
dc.subject.keywordpediatric intensive care uniteng
dc.subject.lembPediatríaspa
dc.titleInfección por virus sincitial respiratorio y su relación con valores de IGG en niños críticosspa
dc.typemasterThesiseng
dc.type.hasVersioninfo:eu-repo/semantics/acceptedVersion
dc.type.spaTrabajo de gradospa
Archivos
Bloque original
Mostrando1 - 1 de 1
Miniatura
Nombre:
BonillaGonzalez-Carolina-2016.pdf
Tamaño:
568.48 KB
Formato:
Adobe Portable Document Format
Descripción:
Descargar
Colecciones
Especialización en Cuidado Intensivo Pediátrico