Epigenetics and autoimmune diseases

Quintero-Ronderos, Paula; Montoya-Ortiz, Gladis

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Epigenetics and autoimmune diseases

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dc.audience	Comunidad Rosarista	spa
dc.creator	Quintero-Ronderos, Paula
dc.creator	Montoya-Ortiz, Gladis
dc.creator.google	Quintero-Ronderos, Paula
dc.creator.google	Montoya-Ortiz, Gladis
dc.date.accessioned	2014-08-11T19:52:24Z
dc.date.available	2014-08-11T19:52:24Z
dc.date.created	2012
dc.date.issued	2012
dc.description.abstract	Epigenetics is defined as the study of all inheritable and potentially reversible changes in genome function that do not alter the nucleotide sequence within the DNA. Epigenetic mechanisms such as DNA methylation, histone modification, nucleosome positioning, and microRNAs (miRNAs) are essential to carry out key functions in the regulation of gene expression. Therefore, the epigenetic mechanisms are a window to understanding the possible mechanisms involved in the pathogenesis of complex diseases such as autoimmune diseases. It is noteworthy that autoimmune diseases do not have the same epidemiology, pathology, or symptoms but do have a common origin that can be explained by the sharing of immunogenetic mechanisms. Currently, epigenetic research is looking for disruption in one or more epigenetic mechanisms to provide new insights into autoimmune diseases. The identification of cell-specific targets of epigenetic deregulation will serve us as clinical markers for diagnosis, disease progression, and therapy approaches.	eng
dc.format.medium	Recurso electrónico	spa
dc.format.mimetype	application/pdf
dc.format.tipo	Documento	spa
dc.identifier.issn	ISSN:2090-0430
dc.identifier.uri	http://repository.urosario.edu.co/handle/10336/8777
dc.language.iso	eng
dc.publisher	Universidad del Rosario	spa
dc.relation.citationTitle	Autoimmune Diseases
dc.relation.ispartof	Autoimmune Diseases, ISSN 2090-04-30, 2012	spa
dc.rights.accesRights	info:eu-repo/semantics/openAccess
dc.rights.acceso	Abierto (Texto completo)	spa
dc.rights.licencia	EL AUTOR, manifiesta que la obra objeto de la presente autorización es original y la realizó sin violar o usurpar derechos de autor de terceros, por lo tanto la obra es de exclusiva autoría y tiene la titularidad sobre la misma.	spa
dc.source.instname	instname:Universidad del Rosario	spa
dc.source.reponame	reponame:Repositorio Institucional EdocUR	spa
dc.subject.ddc	Enfermedades
dc.subject.decs	Genética	spa
dc.subject.decs	Represión Epigenética	spa
dc.subject.decs	Enfermedades autoinmunes	spa
dc.subject.decs	Inmunología	spa
dc.title	Epigenetics and autoimmune diseases	spa
dc.type	article	eng
dc.type.hasVersion	info:eu-repo/semantics/acceptedVersion
dc.type.spa	Artículo	spa