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Shared HLA Class II in Six Autoimmune Diseases in Latin America: A Meta-Analysis

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dc.audienceComunidad Rosaristaspa
dc.creatorCruz-Tapias, Paola
dc.creatorPerez-Fernandez, Oscar-Mauricio
dc.creatorRojas-Villarraga, Adriana
dc.creatorRodríguez-Rodríguez, Alberto
dc.creatorArango, María-Teresa
dc.creatorAnaya, Juan-Manuel
dc.creator.googleCruz-Tapias, Paola
dc.creator.googlePerez-Fernandez, Oscar-Mauricio
dc.creator.googleRojas-Villarraga, Adriana
dc.creator.googleRodríguez-Rodríguez, Alberto
dc.creator.googleArango, María-Teresa
dc.creator.googleAnaya, Juan-Manuel
dc.date.accessioned2014-08-11T19:11:45Z
dc.date.available2014-08-11T19:11:45Z
dc.date.created2012-10-15
dc.date.issued2012
dc.description.abstractThe prevalence and genetic susceptibility of autoimmune diseases (ADs) may vary depending on latitudinal gradient and ethnicity. The aims of this study were to identify common human leukocyte antigen (HLA) class II alleles that contribute to susceptibility to six ADs in Latin Americans through a meta-analysis and to review additional clinical, immunological, and genetic characteristics of those ADs sharing HLA alleles. DRB1∗03:01 (OR: 4.04; 95%CI: 1.41–11.53) was found to be a risk factor for systemic lupus erythematosus (SLE), Sjogren’s syndrome (SS), and type 1 diabetes mellitus (T1D). DRB1 ¨ ∗04:05 (OR: 4.64; 95%CI: 2.14–10.05) influences autoimmune hepatitis (AIH), rheumatoid arthritis (RA), and T1D; DRB1∗04:01 (OR: 3.86; 95%CI: 2.32–6.42) is a susceptibility factor for RA and T1D. Opposite associations were found between multiple sclerosis (MS) and T1D. DQB1∗06:02 and DRB1∗15 alleles were risk factors for MS but protective factors for T1D. Likewise, DQB1∗06:03 allele was a risk factor for AIH but a protective one for T1D. Several common autoantibodies and clinical associations as well as additional shared genes have been reported in these ADs, which are reviewed herein. These results indicate that in Latin Americans ADs share major loci and immune characteristics.eng
dc.format.mediumRecurso electrónicospa
dc.format.mimetypeapplication/pdf
dc.format.tipoDocumentospa
dc.identifier.issnISSN:2090-0430
dc.identifier.urihttp://repository.urosario.edu.co/handle/10336/8775
dc.language.isoeng
dc.publisherUniversidad del Rosariospa
dc.relation.citationTitleAutoimmune Diseases
dc.relation.ispartofAutoimmune Diseases, ISSN 2090-04-30, 2012spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto completo)spa
dc.rights.licenciaEL AUTOR, manifiesta que la obra objeto de la presente autorización es original y la realizó sin violar o usurpar derechos de autor de terceros, por lo tanto la obra es de exclusiva autoría y tiene la titularidad sobre la misma.spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.ddcEnfermedades
dc.subject.decsHepatitis autoinmunespa
dc.subject.decsArtritis reumatoidespa
dc.subject.decsEsclerosis múltiplespa
dc.subject.decsInmunologíaspa
dc.titleShared HLA Class II in Six Autoimmune Diseases in Latin America: A Meta-Analysisspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/acceptedVersion
dc.type.spaArtículospa
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