Ítem
Acceso Abierto

Asociación entre temperatura corporal al ingreso a urgencias y mortalidad intrahospitalaria en pacientes sépticos

Mostrar el registro sencillo de la publicación
dc.contributorDevia, German
dc.contributor.advisorSanabria Rangel, José Mauricio
dc.creatorBuitrago, Tatiana Patricia
dc.creator.degreeMagíster en epidemiologíaspa
dc.creator.degreetypeFull timespa
dc.date.accessioned2018-10-04T20:54:21Z
dc.date.available2018-10-04T20:54:21Z
dc.date.created2018-09-05
dc.date.issued2018
dc.descriptionObjetivo: Estimar la asociación entre la temperatura corporal de ingreso y la mortalidad intrahospitalaria en pacientes con diagnóstico de sepsis ingresados a Salem Méderi Hospital Universitario Mayor entre febrero a julio de 2017. Metodología: Estudio de cohortes prospectiva analítica entre febrero a julio de 2017 de pacientes que ingresaron a Salem, a quienes se les diagnosticó sepsis, tomándose la temperatura al ingreso y se analizó mortalidad intrahospitalaria, ajustándose a otras variables independientes. Resultados: Se analizaron 171 pacientes con diagnóstico de sepsis, con mediana para edad de 71 años (RIC 17). Los focos sépticos más frecuentes fueron abdominal 38%, pulmonar 28.1% y urinario 24.6%. La incidencia de normotermia, hipotermia e hipertermia fue 59.1%, 28.7% y 12.3% respectivamente. La mortalidad intrahospitalaria fue de 32,2% y 49,1% presentó shock séptico. El riesgo Relativo (RR) para mortalidad intrahospitalaria según hipotermia Vs No hipotermia es 1,58 IC 95% (0,85 - 2,84) p = 0,056. La incidencia de muerte en los pacientes hipotérmicos es de 4,2 por 100 días paciente hospitalizado, comparado con una incidencia de muerte en los pacientes sin hipotermia de 2,6 por 100 días-paciente hospitalizado; no siendo estadísticamente significativo (p=0,056). Conclusiones: En el modelo de regresión logística, las variables con mayor significancia para predecir la mortalidad intrahospitalaria fueron foco pulmonar, shock séptico, focos sépticos distintos al urinario (abdominal y otros focos), tipificación de Gram negativos más que Gram positivos. La hiperlactatemia perdió su asociación al ajustarla; por su parte la neutrofilia se evidenció como un factor protector. En esta cohorte no se encontró asociación directa entre la temperatura corporal y mortalidad intrahospitalaria; pero si hay una tendencia, aunque no es estadísticamente significativa entre presentar hipotermia y mortalidad. La mortalidad de esta población es sustancialmente elevada.spa
dc.description.abstractObjective: To estimate the association between admission body temperature and in-hospital mortality in patients diagnosed with sepsis admitted to Salem Méderi Hospital Universitario Mayor between February and July 2017. Methodology: Analytical prospective cohort study between February and July 2017 of patients who were admitted to Salem, who were diagnosed with sepsis, taking their temperature at admission and in-hospital mortality was analyzed, adjusting to other independent variables. Results: 171 patients with a diagnosis of sepsis were analyzed, with a median age of 71 years (IQR 17). The most frequent septic foci were abdominal 38%, pulmonary 28. 1% and urinary 24. 6%. The incidence of normothermia, hypothermia, and hyperthermia was 59. 1%, 28. 7%, and 12. 3%, respectively. In-hospital mortality was 32. 2% and 49. 1% presented septic shock. The Relative Risk (RR) for in-hospital mortality according to hypothermia Vs Non-hypothermia is 1. 58 95% CI (0. 85 - 2. 84) p = 0. 056. The incidence of death in hypothermic patients is 4. 2 per 100 hospitalized patient days, compared with an incidence of death in non-hypothermic patients of 2. 6 per 100 hospitalized patient days; not being statistically significant (p = 0. 056). Conclusions: In the logistic regression model, the variables with the greatest significance for predicting in-hospital mortality were pulmonary focus, septic shock, septic foci other than urinary (abdominal and other foci), Gram negative rather than Gram positive typing. Hyperlactatemia lost its association when adjusted; on the other hand, neutrophilia was evidenced as a protective factor. In this cohort, no direct association was found between body temperature and in-hospital mortality; but there is a trend, although it is not statistically significant between presenting hypothermia and mortality. The mortality of this population is substantially high. eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.48713/10336_18610
dc.identifier.urihttp://repository.urosario.edu.co/handle/10336/18610
dc.language.isospa
dc.publisherUniversidad del Rosariospa
dc.publisher.departmentFacultad de medicinaspa
dc.publisher.programMaestría en Epidemiologíaspa
dc.rightsAtribución-NoComercial-SinDerivadas 2.5 Colombiaspa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.rights.licenciaEL AUTOR, manifiesta que la obra objeto de la presente autorización es original y la realizó sin violar o usurpar derechos de autor de terceros, por lo tanto la obra es de exclusiva autoría y tiene la titularidad sobre la misma. PARGRAFO: En caso de presentarse cualquier reclamación o acción por parte de un tercero en cuanto a los derechos de autor sobre la obra en cuestión, EL AUTOR, asumirá toda la responsabilidad, y saldrá en defensa de los derechos aquí autorizados; para todos los efectos la universidad actúa como un tercero de buena fe. EL AUTOR, autoriza a LA UNIVERSIDAD DEL ROSARIO, para que en los términos establecidos en la Ley 23 de 1982, Ley 44 de 1993, Decisión andina 351 de 1993, Decreto 460 de 1995 y demás normas generales sobre la materia, utilice y use la obra objeto de la presente autorización. -------------------------------------- POLITICA DE TRATAMIENTO DE DATOS PERSONALES. Declaro que autorizo previa y de forma informada el tratamiento de mis datos personales por parte de LA UNIVERSIDAD DEL ROSARIO para fines académicos y en aplicación de convenios con terceros o servicios conexos con actividades propias de la academia, con estricto cumplimiento de los principios de ley. Para el correcto ejercicio de mi derecho de habeas data cuento con la cuenta de correo habeasdata@urosario.edu.co, donde previa identificación podré solicitar la consulta, corrección y supresión de mis datos.spa
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/2.5/co/
dc.source.bibliographicCitationSinger M, Deutschman CS, Seymour CW, Shankar-Hari M, Annane D, Bauer M, et al. The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). Jama. 2016;315(8):801-10.spa
dc.source.bibliographicCitationKushimoto S, Gando S, Saitoh D, Mayumi T, Ogura H, Fujishima S, et al. The impact of body temperature abnormalities on the disease severity and outcome in patients with severe sepsis: an analysis from a multicenter, prospective survey of severe sepsis. Crit Care. 2013;17(6):R271.spa
dc.source.bibliographicCitationYamamoto S, Yamazaki S, Shimizu T, Takeshima T, Fukuma S, Yamamoto Y, et al. Body Temperature at the Emergency Department as a Predictor of Mortality in Patients With Bacterial Infection. Medicine (Baltimore). 2016;95(21):e3628.spa
dc.source.bibliographicCitationSunden-Cullberg J, Rylance R, Svefors J, Norrby-Teglund A, Bjork J, Inghammar M. Fever in the Emergency Department Predicts Survival of Patients With Severe Sepsis and Septic Shock Admitted to the ICU. Crit Care Med. 2017;45(4):591-9.spa
dc.source.bibliographicCitationTiruvoipati R, Ong K, Gangopadhyay H, Arora S, Carney I, Botha J. Hypothermia predicts mortality in critically ill elderly patients with sepsis. BMC Geriatr. 2010;10:70.spa
dc.source.bibliographicCitationDrewry AM, Fuller BM, Skrupky LP, Hotchkiss RS. The presence of hypothermia within 24 hours of sepsis diagnosis predicts persistent lymphopenia. Crit Care Med. 2015;43(6):1165-9.spa
dc.source.bibliographicCitationPeres Bota D, Lopes Ferreira F, Melot C, Vincent JL. Body temperature alterations in the critically ill. Intensive Care Med. 2004;30(5):811-6.spa
dc.source.bibliographicCitationLaupland KB, Shahpori R, Kirkpatrick AW, Ross T, Gregson DB, Stelfox HT. Occurrence and outcome of fever in critically ill adults. Crit Care Med. 2008;36(5):1531-5.spa
dc.source.bibliographicCitationLaupland KB, Zahar JR, Adrie C, Schwebel C, Goldgran-Toledano D, Azoulay E, et al. Determinants of temperature abnormalities and influence on outcome of critical illness. Crit Care Med. 2012;40(1):145-51.spa
dc.source.bibliographicCitationNiven DJ, Laupland KB, Tabah A, Vesin A, Rello J, Koulenti D, et al. Diagnosis and management of temperature abnormality in ICUs: a EUROBACT investigators' survey. Crit Care. 2013;17(6):R289.spa
dc.source.bibliographicCitationYoung PJ, Saxena M, Beasley R, Bellomo R, Bailey M, Pilcher D, et al. Early peak temperature and mortality in critically ill patients with or without infection. Intensive Care Med. 2012.spa
dc.source.bibliographicCitationManthous CA, Hall JB, Olson D, Singh M, Chatila W, Pohlman A, et al. Effect of cooling on oxygen consumption in febrile critically ill patients. Am J Respir Crit Care Med. 1995;151(1):10-4.spa
dc.source.bibliographicCitationL'Her E, Amerand A, Vettier A, Sebert P. Effects of mild induced hypothermia during experimental sepsis. Crit Care Med. 2006;34(10):2621-3.spa
dc.source.bibliographicCitationChang YT, Wann SR, Tsai JS, Kao CH, Lee PT, Huang NC, et al. The role of autonomic nervous system function in hypothermia-mediated sepsis protection. Am J Emerg Med. 2013;31(2):375-80.spa
dc.source.bibliographicCitationMohr N, Skrupky L, Fuller B, Moy H, Alunday R, Wallendorf M, et al. Early antipyretic exposure does not increase mortality in patients with gram-negative severe sepsis: a retrospective cohort study. Intern Emerg Med. 2012;7(5):463-70.spa
dc.source.bibliographicCitationMohr NM, Fuller BM, Skrupky LP, Moy H, Alunday R, Micek ST, et al. Clinical and demographic factors associated with antipyretic use in gram-negative severe sepsis and septic shock. Ann Pharmacother. 2011;45(10):1207-16.spa
dc.source.bibliographicCitationZhang Z, Chen L, Ni H. Antipyretic therapy in critically ill patients with sepsis: an interaction with body temperature. PLoS One. 2015;10(3):e0121919.spa
dc.source.bibliographicCitationLee BH, Inui D, Suh GY, Kim JY, Kwon JY, Park J, et al. Association of body temperature and antipyretic treatments with mortality of critically ill patients with and without sepsis: multi-centered prospective observational study. Crit Care. 2012;16(1):R33.spa
dc.source.bibliographicCitationBernard GR, Wheeler AP, Russell JA, Schein R, Summer WR, Steinberg KP, et al. The effects of ibuprofen on the physiology and survival of patients with sepsis. The Ibuprofen in Sepsis Study Group. N Engl J Med. 1997;336(13):912-8.spa
dc.source.bibliographicCitationNiño Mantilla M, Torres Dueñas D, Maria CA. Factores pronósticos de mortalidad por sepsis severa en unidadesde cuidado crítico del área metropolitana de Bucaramanga. MedUNAB2012. p. 7-13.spa
dc.source.bibliographicCitationAlzate Atehortua M. caracterización de la sepsis severa y choque séptico en unauci de la ciudad de pereira, colombia. In: Martínez García R, editor. trabajo de grado para optar al título deespecialista en medicina crítica y cuidado intensivo2015.spa
dc.source.bibliographicCitationMolina FJ, Diaz CA, Barrera L, De La Rosa G, Dennis R, Duenas C, et al. [Microbiological profile of infections in the Intensive Care Units of Colombia (EPISEPSIS Colombia]. Med Intensiva. 2011;35(2):75-83.spa
dc.source.bibliographicCitationOrtiz G, Duenas C, Rodriguez F, Barrera L, de La Rosa G, Dennis R, et al. Epidemiology of sepsis in Colombian intensive care units. Biomedica. 2014;34(1):40-7.spa
dc.source.bibliographicCitationLopez Vallejo CsA. Epidemiologia de la sepsis en la Fundaci?n Cardioinfantil - Instituto de Cardiología - Bogotá: Facultad de Medicina.spa
dc.source.bibliographicCitationGomez Duque M, Enciso Olivera C, Pena Torres E, Segura Duran OD, Nieto Estrada VH. [ECAIS study: inadvertent cardiovascular adverse events in sepsis]. Med Intensiva. 2012;36(5):343-50.spa
dc.source.bibliographicCitationCastillo JS, Leal AL, Cortes JA, Alvarez CA, Sanchez R, Buitrago G, et al. Mortality among critically ill patients with methicillin-resistant Staphylococcus aureus bacteremia: a multicenter cohort study in Colombia. Rev Panam Salud Publica. 2012;32(5):343-50.spa
dc.source.bibliographicCitationAsghar A, Hashmi M, Rashid S, Khan FH. Incidence, outcome and risk factors for sepsis--a two year retrospective study at surgical intensive care unit of a teaching hospital in pakistan. J Ayub Med Coll Abbottabad. 2016;28(1):79-83.spa
dc.source.bibliographicCitationFujishima S, Gando S, Daizoh S, Kushimoto S, Ogura H, Mayumi T, et al. Infection site is predictive of outcome in acute lung injury associated with severe sepsis and septic shock. Respirology. 2016;21(5):898-904.spa
dc.source.bibliographicCitationBarreto MF, Dellaroza MS, Kerbauy G, Grion CM. Sepsis in a university hospital: a prospective study for the cost analysis of patients' hospitalization. Rev Esc Enferm USP. 2016;50(2):302-8.spa
dc.source.bibliographicCitationGoodwin AJ, Rice DA, Simpson KN, Ford DW. Frequency, cost, and risk factors of readmissions among severe sepsis survivors. Crit Care Med. 2015;43(4):738-46.spa
dc.source.bibliographicCitationPrkno A, Wacker C, Brunkhorst FM, Schlattmann P. Procalcitonin-guided therapy in intensive care unit patients with severe sepsis and septic shock--a systematic review and meta-analysis. Crit Care. 2013;17(6):R291.spa
dc.source.bibliographicCitationTschaikowsky K, Hedwig-Geissing M, Braun GG, Radespiel-Troeger M. Predictive value of procalcitonin, interleukin-6, and C-reactive protein for survival in postoperative patients with severe sepsis. J Crit Care. 2011;26(1):54-64.spa
dc.source.bibliographicCitationLee SM, Kim SE, Kim EB, Jeong HJ, Son YK, An WS. Lactate Clearance and Vasopressor Seem to Be Predictors for Mortality in Severe Sepsis Patients with Lactic Acidosis Supplementing Sodium Bicarbonate: A Retrospective Analysis. PLoS One. 2015;10(12):e0145181.spa
dc.source.bibliographicCitationZhou X, Liu D, Su L, Yao B, Long Y, Wang X, et al. Use of stepwise lactate kinetics-oriented hemodynamic therapy could improve the clinical outcomes of patients with sepsis-associated hyperlactatemia. Crit Care. 2017;21(1):33.spa
dc.source.bibliographicCitationJones AE, Shapiro NI, Trzeciak S, Arnold RC, Claremont HA, Kline JA. Lactate clearance vs central venous oxygen saturation as goals of early sepsis therapy: a randomized clinical trial. Jama. 2010;303(8):739-46.spa
dc.source.bibliographicCitationLokhandwala S, Andersen LW, Nair S, Patel P, Cocchi MN, Donnino MW. Absolute lactate value vs relative reduction as a predictor of mortality in severe sepsis and septic shock. J Crit Care. 2017;37:179-84.spa
dc.source.bibliographicCitationMallat J, Pepy F, Lemyze M, Gasan G, Vangrunderbeeck N, Tronchon L, et al. Central venous-to-arterial carbon dioxide partial pressure difference in early resuscitation from septic shock: a prospective observational study. Eur J Anaesthesiol. 2014;31(7):371-80.spa
dc.source.bibliographicCitationLauney Y, Nesseler N, Malledant Y, Seguin P. Clinical review: fever in septic ICU patients--friend or foe? Crit Care. 2011;15(3):222.spa
dc.source.bibliographicCitationMohr NM, Doerschug KC. Point: Should antipyretic therapy be given routinely to febrile patients in septic shock? Yes. Chest. 2013;144(4):1096-8; discussion 101-3.spa
dc.source.bibliographicCitationHasday JD, Fairchild KD, Shanholtz C. The role of fever in the infected host. Microbes Infect. 2000;2(15):1891-904.spa
dc.source.bibliographicCitationGozzoli V, Treggiari MM, Kleger GR, Roux-Lombard P, Fathi M, Pichard C, et al. Randomized trial of the effect of antipyresis by metamizol, propacetamol or external cooling on metabolism, hemodynamics and inflammatory response. Intensive Care Med. 2004;30(3):401-7.spa
dc.source.bibliographicCitationArik G, Sengul Aycicek G, Ulger Z. Acetaminophen for Fever in Critically Ill Patients with Suspected Infection. N Engl J Med. 2016;374(13):1292.spa
dc.source.bibliographicCitationLaupland KB, Zahar JR, Adrie C, Minet C, Vesin A, Goldgran-Toledano D, et al. Severe hypothermia increases the risk for intensive care unit-acquired infection. Clin Infect Dis. 2012;54(8):1064-70.spa
dc.source.bibliographicCitationDrewry AM, Hotchkiss RS. Counterpoint: Should antipyretic therapy be given routinely to febrile patients in septic shock? No. Chest. 2013;144(4):1098-101; discussion 101-3.spa
dc.source.bibliographicCitationJenkins DD, Lee T, Chiuzan C, Perkel JK, Rollins LG, Wagner CL, et al. Altered circulating leukocytes and their chemokines in a clinical trial of therapeutic hypothermia for neonatal hypoxic ischemic encephalopathy*. Pediatr Crit Care Med. 2013;14(8):786-95.spa
dc.source.bibliographicCitationRumbus Z, Matics R, Hegyi P, Zsiboras C, Szabo I, Illes A, et al. Fever Is Associated with Reduced, Hypothermia with Increased Mortality in Septic Patients: A Meta-Analysis of Clinical Trials. PLoS One. 2017;12(1):e0170152.spa
dc.source.bibliographicCitationJones AE, Puskarich MA. The Surviving Sepsis Campaign guidelines 2012: update for emergency physicians. Ann Emerg Med. 2014;63(1):35-47.spa
dc.source.bibliographicCitationRhodes A, Evans LE, Alhazzani W, Levy MM, Antonelli M, Ferrer R, et al. Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016. Intensive Care Med. 2017;43(3):304-77.spa
dc.source.bibliographicCitationShapiro NI, Wolfe RE, Moore RB, Smith E, Burdick E, Bates DW. Mortality in Emergency Department Sepsis (MEDS) score: a prospectively derived and validated clinical prediction rule. Crit Care Med. 2003;31(3):670-5.spa
dc.source.bibliographicCitationKnaus WA, Draper EA, Wagner DP, Zimmerman JE. APACHE II: a severity of disease classification system. Crit Care Med. 1985;13(10):818-29.spa
dc.source.bibliographicCitationTsalik EL, Jaggers LB, Glickman SW, Langley RJ, van Velkinburgh JC, Park LP, et al. Discriminative value of inflammatory biomarkers for suspected sepsis. J Emerg Med. 2012;43(1):97-106.spa
dc.source.bibliographicCitationTicinesi A, Lauretani F, Nouvenne A, Porro E, Fanelli G, Maggio M, et al. C-reactive protein (CRP) measurement in geriatric patients hospitalized for acute infection. Eur J Intern Med. 2017;37:7-12.spa
dc.source.bibliographicCitationGuo SY, Zhou Y, Hu QF, Yao J, Wang H. Procalcitonin is a marker of gram-negative bacteremia in patients with sepsis. Am J Med Sci. 2015;349(6):499-504.spa
dc.source.bibliographicCitationSchuetz P, Wirz Y, Sager R, Christ-Crain M, Stolz D, Tamm M, et al. Procalcitonin to initiate or discontinue antibiotics in acute respiratory tract infections. Cochrane Database Syst Rev. 2017;10:Cd007498.spa
dc.source.bibliographicCitationSoni NJ, Samson DJ, Galaydick JL, Vats V, Huang ES, Aronson N, et al. Procalcitonin-guided antibiotic therapy: a systematic review and meta-analysis. J Hosp Med. 2013;8(9):530-40.spa
dc.source.bibliographicCitationAndriolo BN, Andriolo RB, Salomao R, Atallah AN. Effectiveness and safety of procalcitonin evaluation for reducing mortality in adults with sepsis, severe sepsis or septic shock. Cochrane Database Syst Rev. 2017;1:Cd010959.spa
dc.source.bibliographicCitationBessiere F, Khenifer S, Dubourg J, Durieu I, Lega JC. Prognostic value of troponins in sepsis: a meta-analysis. Intensive Care Med. 2013;39(7):1181-9. 58. Kang EW, Na HJ, Hong SM, Shin SK, Kang SW, Choi KH, et al. Prognostic value of elevated cardiac troponin I in ESRD patients with sepsis. Nephrol Dial Transplant. 2009;24(5):1568-73.spa
dc.source.bibliographicCitationSheyin O, Davies O, Duan W, Perez X. The prognostic significance of troponin elevation in patients with sepsis: a meta-analysis. Heart Lung. 2015;44(1):75-81.spa
dc.source.bibliographicCitationO'Grady NP, Barie PS, Bartlett JG, Bleck T, Carroll K, Kalil AC, et al. Guidelines for evaluation of new fever in critically ill adult patients: 2008 update from the American College of Critical Care Medicine and the Infectious Diseases Society of America. Crit Care Med. 2008;36(4):1330-49.spa
dc.source.bibliographicCitationCirciumaru B, Baldock G, Cohen J. A prospective study of fever in the intensive care unit. Intensive Care Med. 1999;25(7):668-73.spa
dc.source.bibliographicCitationArons MM, Wheeler AP, Bernard GR, Christman BW, Russell JA, Schein R, et al. Effects of ibuprofen on the physiology and survival of hypothermic sepsis. Ibuprofen in Sepsis Study Group. Crit Care Med. 1999;27(4):699-707.spa
dc.source.bibliographicCitationAronoff DM, Neilson EG. Antipyretics: mechanisms of action and clinical use in fever suppression. Am J Med. 2001;111(4):304-15.spa
dc.source.bibliographicCitationLaupland KB. Fever in the critically ill medical patient. Crit Care Med. 2009;37(7 Suppl):S273-8.spa
dc.source.bibliographicCitationBadjatia N. Hyperthermia and fever control in brain injury. Crit Care Med. 2009;37(7 Suppl):S250-7.spa
dc.source.bibliographicCitationBonds BW, Hu P, Li Y, Yang S, Colton K, Gonchigar A, et al. Predictive value of hyperthermia and intracranial hypertension on neurological outcomes in patients with severe traumatic brain injury. Brain Inj. 2015;29(13-14):1642-7.spa
dc.source.bibliographicCitationCooper DJ, Nichol A, Presneill J. Hypothermia for Intracranial Hypertension after Traumatic Brain Injury. N Engl J Med. 2016;374(14):1384.spa
dc.source.bibliographicCitationHonig A, Michael S, Eliahou R, Leker RR. Central fever in patients with spontaneous intracerebral hemorrhage: predicting factors and impact on outcome. BMC Neurol. 2015;15:6.spa
dc.source.bibliographicCitationWeir B, Disney L, Grace M, Roberts P. Daily trends in white blood cell count and temperature after subarachnoid hemorrhage from aneurysm. Neurosurgery. 1989;25(2):161-5.spa
dc.source.bibliographicCitationOliveira-Filho J, Ezzeddine MA, Segal AZ, Buonanno FS, Chang Y, Ogilvy CS, et al. Fever in subarachnoid hemorrhage: relationship to vasospasm and outcome. Neurology. 2001;56(10):1299-304.spa
dc.source.bibliographicCitationDorhout Mees SM, Luitse MJ, van den Bergh WM, Rinkel GJ. Fever after aneurysmal subarachnoid hemorrhage: relation with extent of hydrocephalus and amount of extravasated blood. Stroke. 39. United States2008. p. 2141-3.spa
dc.source.bibliographicCitationFernandez A, Schmidt JM, Claassen J, Pavlicova M, Huddleston D, Kreiter KT, et al. Fever after subarachnoid hemorrhage: risk factors and impact on outcome. Neurology. 2007;68(13):1013-9.spa
dc.source.bibliographicCitationNolan JP, Soar J, Cariou A, Cronberg T, Moulaert VR, Deakin CD, et al. European Resuscitation Council and European Society of Intensive Care Medicine 2015 guidelines for post-resuscitation care. Intensive Care Med. 2015;41(12):2039-56.spa
dc.source.bibliographicCitationBaucom RB, Phillips SE, Ehrenfeld JM, Muldoon RL, Poulose BK, Herline AJ, et al. Association of Perioperative Hypothermia During Colectomy With Surgical Site Infection. JAMA Surg. 2015;150(6):570-5.spa
dc.source.bibliographicCitationIshikawa K, Tanaka H, Shiozaki T, Takaoka M, Ogura H, Kishi M, et al. Characteristics of infection and leukocyte count in severely head-injured patients treated with mild hypothermia. J Trauma. 2000;49(5):912-22.spa
dc.source.bibliographicCitationHashiguchi N, Shiozaki T, Ogura H, Tanaka H, Koh T, Noborio M, et al. Mild hypothermia reduces expression of heat shock protein 60 in leukocytes from severely head-injured patients. J Trauma. 2003;55(6):1054-60.spa
dc.source.bibliographicCitationNiven DJ, Stelfox HT, Leger C, Kubes P, Laupland KB. Assessment of the safety and feasibility of administering antipyretic therapy in critically ill adults: a pilot randomized clinical trial. J Crit Care. 2013;28(3):296-302.spa
dc.source.bibliographicCitationPoblete B, Romand JA, Pichard C, Konig P, Suter PM. Metabolic effects of i.v. propacetamol, metamizol or external cooling in critically ill febrile sedated patients. Br J Anaesth. 1997;78(2):123-7.spa
dc.source.bibliographicCitationSchortgen F, Clabault K, Katsahian S, Devaquet J, Mercat A, Deye N, et al. Fever control using external cooling in septic shock: a randomized controlled trial. Am J Respir Crit Care Med. 2012;185(10):1088-95.spa
dc.source.bibliographicCitationYoung PJ, Saxena M. Fever management in intensive care patients with infections. Crit Care. 2014;18(2):206.spa
dc.source.bibliographicCitationHonarmand H, Abdollahi M, Ahmadi A, Javadi MR, Khoshayand MR, Tabeefar H, et al. Randomized trial of the effect of intravenous paracetamol on inflammatory biomarkers and outcome in febrile critically ill adults. Daru. 2012;20(1):12.spa
dc.source.bibliographicCitationLaupland KB, Davies HD, Church DL, Louie TJ, Dool JS, Zygun DA, et al. Bloodstream infection-associated sepsis and septic shock in critically ill adults: a population-based study. Infection. 2004;32(2):59-64.spa
dc.source.bibliographicCitationPittet D, Thievent B, Wenzel RP, Li N, Auckenthaler R, Suter PM. Bedside prediction of mortality from bacteremic sepsis. A dynamic analysis of ICU patients. Am J Respir Crit Care Med. 1996;153(2):684-93.spa
dc.source.bibliographicCitationYoung P, Saxena M, Bellomo R, Freebairn R, Hammond N, van Haren F, et al. Acetaminophen for Fever in Critically Ill Patients with Suspected Infection. The New England Journal Of Medicine. 2015;373(23):2215-24.spa
dc.source.bibliographicCitationGaieski DF, Agarwal AK, Mikkelsen ME, Drumheller B, Cham Sante S, Shofer FS, et al. The impact of ED crowding on early interventions and mortality in patients with severe sepsis. Am J Emerg Med. 2017;35(7):953-60.spa
dc.source.bibliographicCitationYergens DW, Ghali WA, Faris PD, Quan H, Jolley RJ, Doig CJ. Assessing the association between occupancy and outcome in critically Ill hospitalized patients with sepsis. BMC Emerg Med. 2015;15:31.spa
dc.source.bibliographicCitationShih YN, Chen YT, Shih CJ, Ou SM, Hsu YT, Chen RC, et al. Association of weekend effect with early mortality in severe sepsis patients over time. J Infect. 2017;74(4):345-51.spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subjectSepsisspa
dc.subjectShock sépticospa
dc.subjectFiebrespa
dc.subjectMortalidadspa
dc.subjectCuidados críticosspa
dc.subject.ddcEnfermedadesspa
dc.subject.keywordSepsisspa
dc.subject.keywordShock septicspa
dc.subject.keywordFeverspa
dc.subject.keywordMortalityspa
dc.subject.keywordCritical carespa
dc.subject.lembSepticemiaspa
dc.subject.lembTemperatura corporalspa
dc.subject.lembMortalidadspa
dc.titleAsociación entre temperatura corporal al ingreso a urgencias y mortalidad intrahospitalaria en pacientes sépticosspa
dc.typemasterThesiseng
dc.type.hasVersioninfo:eu-repo/semantics/acceptedVersion
dc.type.spaTesis de maestríaspa
Archivos
Bloque original
Mostrando1 - 1 de 1
Miniatura
Nombre:
BUITRAGOTATIANA SEPSIS Y TEMPERATURA.pdf
Tamaño:
1.54 MB
Formato:
Adobe Portable Document Format
Descripción:
documento principal
Descargar
Colecciones
Maestría en Epidemiología