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Using the PfEMP1 Head Structure Binding Motif to Deal a Blow at Severe Malaria

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dc.audienceComunidad Rosaristaspa
dc.creatorPatarroyo, Manuel E.
dc.creatorPatricia Alba, Martha
dc.creatorCurtidor, Hernando
dc.creatorVanegas, Magnolia
dc.creatorAlmonacid, Hannia
dc.creatorPatarroyo, Manuel A.
dc.creator.googlePatarroyo, Manuel E.
dc.creator.googlePatricia Alba, Martha
dc.creator.googleCurtidor, Hernando
dc.creator.googleVanegas, Magnolia
dc.creator.googleAlmonacid, Hannia
dc.creator.googlePatarroyo, Manuel A.
dc.date.accessioned2014-08-12T16:23:29Z
dc.date.available2014-08-12T16:23:29Z
dc.date.created2014-02
dc.date.issued2014
dc.description.abstractPlasmodium falciparum (Pf) malaria causes 200 million cases worldwide, 8 million being severe and complicated leading to similar to 1 million deaths and similar to 100,000 abortions annually. Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) has been implicated in cytoadherence and infected erythrocyte rosette formation, associated with cerebral malaria; chondroitin sulphate-A attachment and infected erythrocyte sequestration related to pregnancy-associated malaria and other severe forms of disease. An endothelial cell high activity binding peptide is described in several of this similar to 300 kDa hypervariable protein's domains displaying a conserved motif (GACxPxRRxxLC); it established H-bonds with other binding peptides to mediate red blood cell group A and chondroitin sulphate attachment. This motif (when properly modified) induced PfEMP1-specific strain-transcending, fully-protective immunity for the first time in experimental challenge in Aotus monkeys, opening the way forward for a long sought-after vaccine against severe malaria.eng
dc.format.mediumRecurso electrónicospa
dc.format.mimetypeapplication/pdf
dc.format.tipoDocumentospa
dc.identifier.doihttps://doi.org/10.1371/journal.pone.0088420
dc.identifier.issnISSN:1932-6203
dc.identifier.urihttp://repository.urosario.edu.co/handle/10336/8808
dc.language.isoeng
dc.publisherUniversidad del Rosariospa
dc.relation.citationIssueNo. 2
dc.relation.citationTitlePLOS ONE
dc.relation.citationVolumeVol. 9
dc.relation.ispartofPLOS ONE ISSN: 1932-6203 V. 9 N. 2 Feb 7, 2014spa
dc.relation.urihttp://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0088420
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto completo)spa
dc.rights.licenciaEL AUTOR, manifiesta que la obra objeto de la presente autorización es original y la realizó sin violar o usurpar derechos de autor de terceros, por lo tanto la obra es de exclusiva autoría y tiene la titularidad sobre la misma.spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.ddcEnfermedades
dc.subject.decsPlasmodiumspa
dc.subject.decsMalariaspa
dc.subject.decsInmunologíaspa
dc.subject.keywordErythrocyte-membrane PROTEIN-1eng
dc.subject.keywordChondroitin-sulfate-aeng
dc.subject.keywordPlasmodium-falciparumeng
dc.subject.keywordAntimalarial Vaccineeng
dc.subject.keywordPlacental Malariaeng
dc.subject.keywordALPHA-Domainseng
dc.subject.keywordExpressioneng
dc.subject.keywordAntibodieseng
dc.subject.keywordParasiteseng
dc.subject.keywordPaptideseng
dc.titleUsing the PfEMP1 Head Structure Binding Motif to Deal a Blow at Severe Malariaspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/acceptedVersion
dc.type.spaArtículospa
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