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Plasmapheresis vs. immunoglobulin in autoimmune neurologic diseases: a meta-analysis

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dc.contributor.advisorVélez van Meerbeke, Alberto Francisco
dc.creatorOrtíz Salas, Paola
dc.creator.degreeEspecialista en Neurología
dc.date.accessioned2014-06-24T14:17:35Z
dc.date.available2014-06-24T14:17:35Z
dc.date.created2014-06-05
dc.date.issued2014
dc.description.abstractObjectives: to evaluate the efficacy and safety of human immunoglobulin versus plasmapheresis in the management of autoimmune neurologic diseases. Likewise, length of hospital stay and duration of ventilator support were compared. Methods: Randomized controlled trials and analytical observational studies of more than 10 cases, were reviewed. Cochrane Neuromuscular Disease Group trials, MEDLINE, EMBASE, HINARI Ovid, the Database of abstracts of reviews of effectiveness and the Economic evaluation Database were searched as data source. Reference lists were examined for further relevant articles. A random-effect model was used to derive a pooled risk ratio. Results: 725 articles were found and 27 met the criteria for a population studied of 4717 cases: 14 articles were about Guillain Barré syndrome, 10 of Myasthenia Gravis, one of Sydenham Chorea, one of Chronic inflammatory demyelinating polyneuropathy, and one of PANDAS. No evidence was found in favor of any of the two treatments as regards effectiveness (OR 0. 94, IC 0. 63 – 1. 41, p= 0. 77) or ventilator support time; IGIV had a significant better safety profile than plasmapheresis (OR 0. 70, IC 0. 51 – 0. 96, p= 0. 03) and patients needed less time of hospital stay (p=0. 03). Conclusions: There is no evidence for superiority in the effectiveness of immunoglobulin or plasmapheresis in the management of autoimmune neurologic diseases. Nevertheless, patients treated with immunoglobulin have statistically significant less adverse effects, a shorter hospital stay and a tendency of less ventilator support time. These premises could lead to fewer costs for health services but an economic study should be done. eng
dc.format.mimetypeapplication/pdf
dc.format.tipoDocumentospa
dc.identifier.doihttps://doi.org/10.48713/10336_5705
dc.identifier.urihttp://repository.urosario.edu.co/handle/10336/5705
dc.language.isospa
dc.publisherUniversidad del Rosariospa
dc.publisher.departmentFacultad de Medicinaspa
dc.publisher.programEspecialización en Neurologíaspa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto completo)spa
dc.rights.ccCC0 1.0 Universalspa
dc.rights.licenciaEL AUTOR, manifiesta que la obra objeto de la presente autorización es original y la realizó sin violar o usurpar derechos de autor de terceros, por lo tanto la obra es de exclusiva autoría y tiene la titularidad sobre la misma. PARÁGRAFO: En caso de presentarse cualquier reclamación o acción por parte de un tercero en cuanto a los derechos de autor sobre la obra en cuestión, EL AUTOR, asumirá toda la responsabilidad, y saldrá en defensa de los derechos aquí autorizados; para todos los efectos la universidad actúa como un tercero de buena fe. EL AUTOR, autoriza a LA UNIVERSIDAD DEL ROSARIO, para que en los términos establecidos en la Ley 23 de 1982, Ley 44 de 1993, Decisión andina 351 de 1993, Decreto 460 de 1995 y demás normas generales sobre la materia, utilice y use la obra objeto de la presente autorizaciónspa
dc.rights.urihttp://creativecommons.org/publicdomain/zero/1.0/
dc.source.bibliographicCitationAnaya J. Common mechanisms of autoimmune diseases (the autoimmune tautology). Autoimmun Rev. 2012;11:781–784.
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subjectEnfermedades neurológicas autoinmunesspa
dc.subjectIntercambio de plasmaspa
dc.subjectInmunoglobulinaspa
dc.subjectEficaciaspa
dc.subjectEfectos adversosspa
dc.subject.ddcEnfermedades
dc.subject.decsNeurologíaspa
dc.subject.decsEnfermedad autoinmunespa
dc.subject.decsInmunologíaspa
dc.subject.decsInmunoglobulinaspa
dc.subject.keywordAutoimmune neurologic diseaseseng
dc.subject.keywordPlasma Exchangeeng
dc.subject.keywordImmunoglobulineng
dc.subject.keywordEffectivenesseng
dc.subject.keywordAdverse Effectseng
dc.titlePlasmapheresis vs. immunoglobulin in autoimmune neurologic diseases: a meta-analysisspa
dc.typemasterThesiseng
dc.type.hasVersioninfo:eu-repo/semantics/acceptedVersion
dc.type.spaTrabajo de gradospa
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