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Heritabilities, proportions of heritabilities explained by GWAS findings, and implications of cross-phenotype effects on PR interval

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dc.creatorTamar Silva, Claudia
dc.creatorKors, Jan A.
dc.creatorAmin, Najaf
dc.creatorDehghan, Abbas
dc.creatorWitteman, Jacqueline C. M.
dc.creatorWillemsen, Rob
dc.creatorOostra, Ben A.
dc.creatorvan Duijn, Cornelia
dc.creatorIsaacs, Aaron
dc.creator.googleTamar Silva, Claudia
dc.creator.googleKors, Jan A.
dc.creator.googleAmin, Najaf
dc.creator.googleDehghan, Abbas
dc.creator.googleWitteman, Jacqueline C. M.
dc.creator.googleWillemsen, Rob
dc.creator.googleOostra, Ben A.
dc.creator.googlevan Duijn, Cornelia M.
dc.creator.googleIsaacs, Aaron
dc.date.accessioned2019-02-06T15:55:52Z
dc.date.available2019-02-06T15:55:52Z
dc.date.created2015
dc.date.issued2015
dc.description.abstractElectrocardiogram (ECG) measurements are a powerful tool for evaluating cardiac function and are widely used for the diagnosis and prediction of a variety of conditions, including myocardial infarction, cardiac arrhythmias, and sudden cardiac death. Recently, genome-wide association studies (GWASs) identified a large number of genes related to ECG parameter variability, specifically for the QT, QRS, and PR intervals. The aims of this study were to establish the heritability of ECG traits, including indices of left ventricular hypertrophy, and to directly assess the proportion of those heritabilities explained by GWAS variants. These analyses were conducted in a large, Dutch family-based cohort study, the Erasmus Rucphen Family study using variance component methods implemented in the SOLAR (Sequential Oligogenic Linkage Analysis Routines) software package. Heritability estimates ranged from 34 % for QRS and Cornell voltage product to 49 % for 12-lead sum. Trait-specific GWAS findings for each trait explained a fraction of their heritability (17 % for QRS, 4 % for QT, 2 % for PR, 3 % for Sokolow–Lyon index, and 4 % for 12-lead sum). The inclusion of all ECG-associated single nucleotide polymorphisms explained an additional 6 % of the heritability of PR. In conclusion, this study shows that, although GWAS explain a portion of ECG trait variability, a large amount of heritability remains to be explained. In addition, larger GWAS for PR are likely to detect loci already identified, particularly those observed for QRS and 12-lead sum. © 2015, The Author(s).eng
dc.format.mimetypeapplication/pdf
dc.identifier.issnISSN 0340-6717
dc.identifier.urihttp://repository.urosario.edu.co/handle/10336/19019
dc.language.isoengspa
dc.relation.citationEndPage1219
dc.relation.citationIssueNo. 43445
dc.relation.citationStartPage1211
dc.relation.citationTitleHuman Genetics
dc.relation.citationVolumeVol. 134
dc.relation.ispartofHuman Genetics, ISSN: 0340-6717, Vol. 134/No. 43445 (2015) pp. 1211-1219spa
dc.relation.urihttps://link.springer.com/content/pdf/10.1007%2Fs00439-015-1595-9.pdfspa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.rights.cchttps://creativecommons.org/licenses/by/4.0/spa
dc.source.bibliographicCitationGuidelines subcommittee J Hypertens, 17, pp. 151-183spa
dc.source.instnameinstname:Universidad del Rosario
dc.source.reponamereponame:Repositorio Institucional EdocUR
dc.subjectAntihypertensive Agentspa
dc.subjectHeritablespa
dc.subjectAssessment Of Humansspa
dc.subjectClinical Assessmentspa
dc.subjectCohort Analysisspa
dc.subjectControlled Studyspa
dc.subjectData Analysis Softwarespa
dc.subjectElectrocardiographyspa
dc.subjectFamilyspa
dc.subjectFamily Studyspa
dc.subjectGene Frequencyspa
dc.subjectGene Locusspa
dc.subjectGenetic Associationspa
dc.subjectGenetic Traitspa
dc.subjectGenetic Variabilityspa
dc.subjectHeart Arrhythmiaspa
dc.subjectHeart Indexspa
dc.subjectHeart Left Ventricle Hypertrophyspa
dc.subjectHeritabilityspa
dc.subjectHumanspa
dc.subjectHypertensionspa
dc.subjectLinkage Analysisspa
dc.subjectMajor Clinical Studyspa
dc.subjectMalespa
dc.subjectPhenotypespa
dc.subjectPr Intervalspa
dc.subjectPriority Journalspa
dc.subjectQt Intervalspa
dc.subjectSingle Nucleotide Polymorphismspa
dc.subjectSokolow Lyon Indexspa
dc.subjectVariancespa
dc.subjectElectrocardiographyspa
dc.subjectGenetic Linkagespa
dc.subjectGenetic Predispositionspa
dc.subjectGeneticsspa
dc.subjectGenome-Wide Association Studyspa
dc.subjectHeartspa
dc.subjectHeart Ratespa
dc.subjectPhysiologyspa
dc.subjectQuantitative Traitspa
dc.subjectCohort Studiesspa
dc.subjectElectrocardiographyspa
dc.subjectGenetic Linkagespa
dc.subjectGenetic Predisposition To Diseasespa
dc.subjectGenome-Wide Association Studyspa
dc.subjectHeartspa
dc.subjectHeart Ratespa
dc.subjectHypertrophyspa
dc.subjectMalespa
dc.subjectPhenotypespa
dc.subjectPolymorphismspa
dc.subjectQuantitative Traitspa
dc.subject.ddcEvolución & genéticaspa
dc.subject.keywordAdultspa
dc.subject.keywordArticlespa
dc.subject.keywordFemalespa
dc.subject.keywordMiddle Agedspa
dc.subject.keywordAdultspa
dc.subject.keywordFemalespa
dc.subject.keywordHumansspa
dc.subject.keywordMiddle Agedspa
dc.subject.lembFenotiposspa
dc.subject.lembElectrocardiografíaspa
dc.subject.lembEnfermedades cardiacasspa
dc.titleHeritabilities, proportions of heritabilities explained by GWAS findings, and implications of cross-phenotype effects on PR intervalspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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