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Hiperautofluorescencia foveal como factor predictor de recuperación visual en pacientes con desprendimiento regmatógeno de retina

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dc.contributor.advisorRodríguez Alvira, Francisco José
dc.creatorBrieke, Anne Charlotte
dc.creatorTovar Cuevas, José Rafael
dc.creator.degreeEspecialista en Retina y Vítreo
dc.date.accessioned2014-01-16T19:23:39Z
dc.date.available2014-01-16T19:23:39Z
dc.date.created2013-12-06
dc.date.issued2013
dc.descriptionIntroducción: una de las causas de pobre ganancia visual luego de un tratamiento exitoso de desprendimiento de retina, sin complicaciones, es el daño de los fotoreceptores, reflejada en una disrupción de la capa de la zona elipsoide y membrana limitante externa (MLE). En otras patologías se ha demostrado que la hiperautofluorescencia foveal se correlaciona con la integridad de la zona elipsoide y MLE y una mejor recuperación visual. Objetivos: evaluar la asociación entre la hiperautofluorescencia foveal, la integridad de la capa de la zona elipsoide y recuperación visual luego de desprendimiento de retina regmatógeno (DRR) exitosamente tratado. Evaluar la concordancia inter-evaluador de estos exámenes. Metodología: estudio de corte transversal de autofluorescencia foveal y tomografía óptica coherente macular de dominio espectral en 65 pacientes con DRR evaluados por 3 evaluadores independientes. La concordancia inter-evaluador se estudio mediante Kappa de Cohen y la asociación entre las diferentes variables mediante la prueba chi cuadrado y pruebas Z para comparación de proporciones. Resultados: La concordancia de la autofluorescencia fue razonable y la de la tomografía óptica coherente macular buena a muy buena. Sujetos que presentaron hiperautofluorescencia foveal asociada a integridad de la capa de la zona elipsoide tuvieron 20% más de posibilidad de recuperar agudeza visual final mejor a 20/50 que los que no cumplieron éstas características. Conclusión: Existe una asociación clínicamente importante entre la hiperautofluorescencia foveal, la integridad de la capa de zona elipsoide y la mejor agudeza visual final, sin embargo ésta no fue estadísticamente significativa (p=0.39)spa
dc.description.abstractIntroduction: photoreceptor damage, reflected in ellipsoid and external limiting membrane (ELM) layer disruption, is one of the causes of poor visual recovery after successful rhegmatogenous retinal detachment. A correlation between foveal hyperautofluorescence, integrity of ellipsoid and ELM layers and better visual recovery has been demonstrated in other pathologies. Purpose: to evaluate the association between foveal hyperautofluorescence, the integrity of ellipsoid layer and visual recovery in patients treated successfully for rhegmatogenous retinal detachment (RRD) and inter evaluator concordance for these exams. Methods: cross-sectional study in which 65 patients with RRD were evaluated by 3 different evaluators with macular spectral-domain optical coherence tomography (SD-OCT) and foveal autofluorescence. Inter evaluator concordance was studied with Cohen´s Kappa and the association between variables was studies with Chi square and Z test for proportions comparison. Results: the concordance for fundus autofluorescence was fair, and good to very good for SD-OCT. People who had foveal hyperfluorescence associated with ellipsoid layer integrity had 20% more chance to have a final visual acuity ≥ 20/50, compared with those who had note. Conclusion: there is a clinically relevant association between foveal hyperautofluorescence, ellipsoid layer integrity and better visual results, however this is not statistically significant (p=0.39)eng
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dc.identifier.doihttps://doi.org/10.48713/10336_4838
dc.identifier.urihttp://repository.urosario.edu.co/handle/10336/4838
dc.language.isospa
dc.publisherUniversidad del Rosariospa
dc.publisher.departmentFacultad de medicinaspa
dc.publisher.programEspecialización en Retina y Vítreospa
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dc.rights.ccAtribución-NoComercial-SinDerivadas 2.5 Colombiaspa
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dc.source.bibliographicCitationArevalo F, Grau-Wiechers F, Quiroz-Mercado H, Rodriguez FJ, Wu L. Retina Quirúrgica Temas Selectos. Amolca, editor. Caracas2011
dc.source.bibliographicCitationSabates NR, Sabates FN, Sabates R, Lee KY, Ziemianski MC. Macular changes after retinal detachment surgery. Am J Ophthalmol. 1989;108(1):22-9
dc.source.bibliographicCitationHagimura N, Iida T, Suto K, Kishi S. Persistent foveal retinal detachment after successful rhegmatogenous retinal detachment surgery. Am J Ophthalmol. 2002;133(4):516-20.
dc.source.bibliographicCitationYetik H, Guzel H, Ozkan S. Structural features of attached retina in rhegmatogenous retinal detachments. Retina. 2004;24(1):63-8
dc.source.bibliographicCitationBenson SE, Schlottmann PG, Bunce C, Xing W, Charteris DG. Optical coherence tomography analysis of the macula after vitrectomy surgery for retinal detachment. Ophthalmology. 2006;113(7):1179-83
dc.source.bibliographicCitationWakabayashi T, Oshima Y, Fujimoto H, Murakami Y, Sakaguchi H, Kusaka S, et al. Foveal microstructure and visual acuity after retinal detachment repair: imaging analysis by Fourier-domain optical coherence tomography. Ophthalmology. 2009;116(3):519-28
dc.source.bibliographicCitationDell'omo R, Mura M, Lesnik Oberstein SY, Bijl H, Tan HS. Early simultaneous fundus autofluorescence and optical coherence tomography features after pars plana vitrectomy for primary rhegmatogenous retinal detachment. Retina. 2012;32(4):719-28
dc.source.bibliographicCitationShiragami C, Shiraga F, Nitta E, Fukuda K, Yamaji H. Correlation of increased fundus autofluorescence signals at closed macula with visual prognosis after successful macular hole surgery. Retina. 2012;32(2):281-8
dc.source.bibliographicCitationRetina and Vitreous. Ophthalmology AAo, editor. San Francisco2009 - 2010
dc.source.bibliographicCitationHaimann MH, Burton TC, Brown CK. Epidemiology of retinal detachment. Arch Ophthalmol. 1982;100(2):289-92
dc.source.bibliographicCitationWilkes SR, Beard CM, Kurland LT, Robertson DM, O'Fallon WM. The incidence of retinal detachment in Rochester, Minnesota, 1970-1978. Am J Ophthalmol. 1982;94(5):670-3
dc.source.bibliographicCitationLaatikainen L, Tolppanen EM, Harju H. Epidemiology of rhegmatogenous retinal detachment in a Finnish population. Acta Ophthalmol (Copenh). 1985;63(1):59-64
dc.source.bibliographicCitationTornquist R, Stenkula S, Tornquist P. Retinal detachment. A study of a population-based patient material in Sweden 1971-1981. I. Epidemiology. Acta Ophthalmol (Copenh). 1987;65(2):213-22
dc.source.bibliographicCitationSasaki K, Ideta H, Yonemoto J, Tanaka S, Hirose A, Oka C. Epidemiologic characteristics of rhegmatogenous retinal detachment in Kumamoto, Japan. Graefes Arch Clin Exp Ophthalmol. 1995;233(12):772-6
dc.source.bibliographicCitationWong TY, Tielsch JM, Schein OD. Racial difference in the incidence of retinal detachment in Singapore. Arch Ophthalmol. 1999;117(3):379-83
dc.source.bibliographicCitationLincoff HA, Baras I, McLean J. MODIFICATIONS TO THE CUSTODIS PROCEDURE FOR RETINAL DETACHMENT. Arch Ophthalmol. 1965;73:160-3
dc.source.bibliographicCitationSchepens CL, Okamura ID, Brockhurst RJ. The scleral buckling procedures. I. Surgical techniques and management. AMA Arch Ophthalmol. 1957;58(6):797-811
dc.source.bibliographicCitationEscoffery R, Olk R, Grand M, Boniuk I. Vitrectomy without scleral buckling for primary rhegmatogenous retinal detachment. Am J Ophthalmol. 1985(3)
dc.source.bibliographicCitationGartry DS, Chignell AH, Franks WA, Wong D. Pars plana vitrectomy for the treatment of rhegmatogenous retinal detachment uncomplicated by advanced proliferative vitreoretinopathy. Br J Ophthalmol. 1993;77(4):199-203
dc.source.bibliographicCitationOshima Y, Yamanishi S, Sawa M, Motokura M, Harino S, Emi K. Two-year follow-up study comparing primary vitrectomy with scleral buckling for macula-off rhegmatogenous retinal detachment. Jpn J Ophthalmol. 2000;44(5):538-49
dc.source.bibliographicCitationArya AV, Emerson JW, Engelbert M, Hagedorn CL, Adelman RA. Surgical management of pseudophakic retinal detachments: a meta-analysis. Ophthalmology. 2006;113(10):1724-33
dc.source.bibliographicCitationKinori M, Moisseiev E, Shoshany N, Fabian ID, Skaat A, Barak A, et al. Comparison of pars plana vitrectomy with and without scleral buckle for the repair of primary rhegmatogenous retinal detachment. Am J Ophthalmol. 2011;152(2):291-7 e2
dc.source.bibliographicCitationTsang CW, Cheung BT, Lam RF, Lee GK, Yuen CY, Lai TY, et al. Primary 23-gauge transconjunctival sutureless vitrectomy for rhegmatogenous retinal detachment. Retina. 2008;28(8):1075-81
dc.source.bibliographicCitationMiller DM, Riemann CD, Foster RE, Petersen MR. Primary repair of retinal detachment with 25-gauge pars plana vitrectomy. Retina. 2008;28(7):931-6
dc.source.bibliographicCitationVon Fricken MA, Kunjukunju N, Weber C, Ko G. 25-Gauge sutureless vitrectomy versus 20-gauge vitrectomy for the repair of primary rhegmatogenous retinal detachment. Retina. 2009;29(4):444-50
dc.source.bibliographicCitationHilton GF, Tornambe PE. Pneumatic retinopexy. An analysis of intraoperative and postoperative complications. The Retinal Detachment Study Group. Retina. 1991;11(3):285-94
dc.source.bibliographicCitationMcAllister IL, Meyers SM, Zegarra H, Gutman FA, Zakov ZN, Beck GJ. Comparison of pneumatic retinopexy with alternative surgical techniques. Ophthalmology. 1988;95(7):877-83
dc.source.bibliographicCitationTornambe PE, Hilton GF. Pneumatic retinopexy. A multicenter randomized controlled clinical trial comparing pneumatic retinopexy with scleral buckling. The Retinal Detachment Study Group. Ophthalmology. 1989;96(6):772-83; discussion 84
dc.source.bibliographicCitationTornambe PE, Hilton GF, Brinton DA, Flood TP, Green S, Grizzard WS, et al. Pneumatic retinopexy. A two-year follow-up study of the multicenter clinical trial comparing pneumatic retinopexy with scleral buckling. Ophthalmology. 1991;98(7):1115-23
dc.source.bibliographicCitationDoyle E, Herbert EN, Bunce C, Williamson TH, Laidlaw DA. How effective is macula-off retinal detachment surgery. Might good outcome be predicted? Eye (Lond). 2007;21(4):534-40
dc.source.bibliographicCitationFriberg TR, Eller AW. Prediction of visual recovery after scleral buckling of macula-off retinal detachments. Am J Ophthalmol. 1992;114(6):715-22
dc.source.bibliographicCitationTani P, Robertson DM, Langworthy A. Prognosis for central vision and anatomic reattachment in rhegmatogenous retinal detachment with macula detached. Am J Ophthalmol. 1981;92(5):611-20
dc.source.bibliographicCitationMowatt L, Tarin S, Nair RG, Menon J, Price NJ. Correlation of visual recovery with macular height in macula-off retinal detachments. Eye (Lond). 2010;24(2):323-7
dc.source.bibliographicCitationMaruko I, Iida T, Sekiryu T, Saito M. Morphologic changes in the outer layer of the detached retina in rhegmatogenous retinal detachment and central serous chorioretinopathy. Am J Ophthalmol. 2009;147(3):489-94.e1
dc.source.bibliographicCitationKim YK, Woo SJ, Park KH, Yu YS, Chung H. Comparison of persistent submacular fluid in vitrectomy and scleral buckle surgery for macula-involving retinal detachment. Am J Ophthalmol. 2010;149(4):623-9 e1
dc.source.bibliographicCitationCavallini GM, Masini C, Volante V, Pupino A, Campi L, Pelloni S. Visual recovery after scleral buckling for macula-off retinal detachments: an optical coherence tomography study. Eur J Ophthalmol. 2007;17(5):790-6
dc.source.bibliographicCitationDelori FC, Dorey CK, Staurenghi G, Arend O, Goger DG, Weiter JJ. In vivo fluorescence of the ocular fundus exhibits retinal pigment epithelium lipofuscin characteristics. Invest Ophthalmol Vis Sci. 1995;36(3):718-29
dc.source.bibliographicCitationvon Ruckmann A, Fitzke FW, Bird AC. Distribution of pigment epithelium autofluorescence in retinal disease state recorded in vivo and its change over time. Graefes Arch Clin Exp Ophthalmol. 1999;237(1):1-9
dc.source.bibliographicCitationSchmitz-Valckenberg S, Holz FG, Bird AC, Spaide RF. Fundus autofluorescence imaging: review and perspectives. Retina. 2008;28(3):385-409
dc.source.bibliographicCitationRosner B. Fundamentals of Biostatistics. USA: Duxbury Press, Harvard University; 1986
dc.source.bibliographicCitationSpaide RF, Curcio CA. Anatomical correlates to the bands seen in the outer retina by optical coherence tomography: literature review and model. Retina. 2011;31(8):1609-19
dc.source.bibliographicCitationSchocket LS, Witkin AJ, Fujimoto JG, Ko TH, Schuman JS, Rogers AH, et al. Ultrahigh-resolution optical coherence tomography in patients with decreased visual acuity after retinal detachment repair. Ophthalmology. 2006;113(4):666-72
dc.source.bibliographicCitationSheth S, Dabir S, Natarajan S, Mhatre A, Labauri N. Spectral domain-optical coherence tomography study of retinas with a normal foveal contour and thickness after retinal detachment surgery. Retina. 2010;30(5):724-32
dc.source.bibliographicCitationLee YS, Yu SY, Cho NS, Kim MS, Kim YG, Kim ES, et al. Association between fundus autofluorescence and visual outcome in surgically closed macular holes. Retina. 2013;33(6):1144-50
dc.source.bibliographicCitationLai WW, Leung GY, Chan CW, Yeung IY, Wong D. Simultaneous spectral domain OCT and fundus autofluorescence imaging of the macula and microperimetric correspondence after successful repair of rhegmatogenous retinal detachment. Br J Ophthalmol. 2010;94(3):311-8
dc.source.bibliographicCitationRoss WH, Kozy DW. Visual recovery in macula-off rhegmatogenous retinal detachments. Ophthalmology. 1998;105(11):2149-53
dc.source.bibliographicCitationMachemer R. Experimental retinal detachment in the owl monkey. II. Histology of retina and pigment epithelium. Am J Ophthalmol. 1968;66(3):396-410
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subjectautofluorescenciaspa
dc.subjectdesprendimiento regmatógeno de retinaspa
dc.subjecttomografía óptica coherentespa
dc.subjectvisiónspa
dc.subject.decsDESPRENDIMIENTO DE RETINAspa
dc.subject.decsTOMOGRAFÍA ÓPTICAspa
dc.subject.keywordautofluorescenceeng
dc.subject.keywordrhegmatogenous retinal detachmenteng
dc.subject.keywordoptic coherent tomographyeng
dc.subject.keywordvisioneng
dc.titleHiperautofluorescencia foveal como factor predictor de recuperación visual en pacientes con desprendimiento regmatógeno de retinaspa
dc.typemasterThesiseng
dc.type.hasVersioninfo:eu-repo/semantics/acceptedVersion
dc.type.spaTrabajo de gradospa
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