@bachelorthesis{10336/12144,
author = {Montañez Rivera, Edwin Alexander},
author = {Prieto Ruiz, Natalia},
year = {2016},
url = {http://repository.urosario.edu.co/handle/10336/12144},
abstract = {Introduction: Colorectal cancer (CRC) is among the 5 types of cancer with the highest incidence worldwide. About 20% of cases are diagnosed in where the treatment was initially chemotherapy with an overall 5-year survival of 12 to 14 months metastatic stages. Thus the role of tumor angiogenesis therapies aimed at developing, implementing use in advanced stages is investigated. Methodology: A systematic search of the databases Embase, PubMed, SciELO and Liliacs data with standardized terms through the MeSH and DECS tool under the guidelines established in the guidelines of systematic reviews and meta-analyzes (Cochrane Manual) Revisions were made. randomized controlled trials were taken with patients with metastatic RCC who have received chemotherapy alone or combined with antiangiogenic therapies, published in English and Spanish between 2003 and 2013. Results: 6 articles met inclusion criteria. These reported 15. 8 months median overall survival in the treatment of chemotherapy-associated biological therapies vs. 14. 4 months with chemotherapy alone. Adverse vascular events increased more in the group of anti-angiogenic, reporting deaths due to intestinal perforations. Conclusions: chemotherapy regimens associated with antiangiogenic therapies provide greater overall and progression-free survival, as well as greater number of response rates. They are therapies with significant adverse events but to be selected either the patient to reduce their risk of events. },
organization = {Universidad del Rosario},
keywords = {Cáncer colorrectal metastásico},
keywords = {terapia anti-angiogénica},
keywords = {quimioterapia en segunda línea},
keywords = {receptor del factor de crecimiento de endotelio vascular},
keywords = {supervivencia global},
title = {Eficacia de  terapias biológicas de tipo anti-angiogénico en el cáncer colorrectal metastásico revisión sistemática de la literatura},
publisher = {Universidad del Rosario},
keywords = {metastatic colorectal cancer},
keywords = {anti-angiogenic therapy},
keywords = {chemotherapy for second-line},
keywords = {growth factor receptor vascular endothelium},
keywords = {overall survival},
}