@mastersthesis{10336/20927,
author = {Gutiérrez Alzate, Jhoan Sebastián},
year = {2020},
month = {1},
url = {https://repository.urosario.edu.co/handle/10336/20927},
abstract = {Background:  Status epilepticus is a  neurological emergency that implies high morbidity and mortality with high costs of attention. Despite international guidelines recommendations for its in-hospital management, there are no results related to the use of available benzodiazepines in Colombia. Objective: To describe results regarding the clinical termination of status epilepticus, understood as the clinical termination or control of epileptic seizures, in patients managed with clonazepam as a first-line treatment. Materials and methods: We conducted a case series study, based on the clonazepam controlled drug database, registered at Fundación Cardioinfantil-Instituto de Cardiología between 2010 and 2018. The results are presented as absolute and relative frequencies for qualitative variables and as medium and interquartile ranges for quantitative. They are also presented according to two analysis groups: clinical termination or progression to refractoriness. Results: We included 88 patients, 56.8% were men, with a median age of 59 years (IQR=31-74). 62.5% of the patients presented clinical termination and 42% progression to refractoriness. More events were resolved with a dose of 1mg of Clonazepam (64.1%), intravenous administration (98.3%) was more frequent. The overall mortality was 2.3%. Conclusion: Clonazepam as a first-line benzodiazepine in the management of status epilepticus, presented a high percentage of crisis termination for this case series.},
keywords = {Estado epiléptico},
keywords = {Clonazepam},
keywords = {Colombia},
title = {Clonazepam como primera línea de manejo en el estado epiléptico en adultos},
publisher = {Universidad del Rosario},
keywords = {Clonazepam},
keywords = {Status epilepticus},
keywords = {Colombia},
doi = {https://doi.org/10.48713/10336_20927 },
}