@article{10336/22784,
author = {Martínez, Paola A.},
author = {Yandar, Nubia},
author = {Lesmes, Liliana P.},
author = {Forero, Martha},
author = {Pérez-Leal, Oscar},
author = {Patarroyo, Manuel Elkin},
author = {Lozano, José Manuel},
year = {2009},
url = {https://repository.urosario.edu.co/handle/10336/22784},
abstract = {We have developed monoclonal antibodies directed against the pseudopeptide ?-130, derived from the highly conserved malarial antigen Plasmodium falciparum merozoite surface protein 2 (MSP-2), for obtaining novel molecular tools with potential applications in the control of malaria. Following isotype switching, these antibodies were tested for their ability to suppress blood-stage parasitemia through passive immunization in malaria-infected mice. Some proved totally effective in suppressing a lethal blood-stage challenge infection and others reduced malarial parasitemia. Protection against P. berghei malaria following Ig passive immunization can be associated with specific immunoglobulins induced by a site-directed designed MSP-2 reduced amide pseudopeptide. © 2008 Elsevier Inc. All rights reserved.},
booktitle = {Peptides, ISSN:1969781, Vol.30, No.2 (2009); pp. 330-342},
title = {Passive transfer of Plasmodium falciparum MSP-2 pseudopeptide-induced antibodies efficiently controlled parasitemia in Plasmodium berghei-infected mice},
keywords = {Immunoglobulin},
keywords = {protozoan},
keywords = {Immunoglobulin class},
keywords = {Malaria vaccine},
keywords = {Merozoite surface protein 2},
keywords = {Monoclonal antibody},
keywords = {Monoclonal antibody anti pseudopeptide psi 130},
keywords = {Pseudopeptide},
keywords = {Unclassified drug},
keywords = {Animal cell},
keywords = {Animal experiment},
keywords = {Animal model},
keywords = {Animal tissue},
keywords = {Article},
keywords = {Controlled study},
keywords = {Drug design},
keywords = {Drug mechanism},
keywords = {Drug synthesis},
keywords = {Female},
keywords = {Mouse},
keywords = {Nonhuman},
keywords = {Parasitemia},
keywords = {Passive immunization},
keywords = {Plasmodium berghei infection},
keywords = {Plasmodium falciparum},
keywords = {Priority journal},
keywords = {Animals},
keywords = {Antibodies, protozoan},
keywords = {Antigens, protozoan},
keywords = {Disease models, animal},
keywords = {Female},
keywords = {Immunization, passive},
keywords = {Malaria},
keywords = {Mice},
keywords = {Mice, inbred balb c},
keywords = {Parasitemia},
keywords = {Plasmodium berghei},
keywords = {Plasmodium falciparum},
keywords = {Protozoan proteins},
keywords = {Recombinant proteins},
keywords = {Murinae},
keywords = {Mus},
keywords = {Plasmodium berghei},
keywords = {Plasmodium falciparum},
keywords = {Anti-malarial vaccine},
keywords = {Ig isotype},
keywords = {In vivo neutralizing activity},
keywords = {Murine malarial infection},
keywords = {Pseudopeptide},
doi = {https://doi.org/10.1016/j.peptides.2008.10.022},
}