@misc{10336/2524,
year = {2011},
url = {http://repository.urosario.edu.co/handle/10336/2524},
abstract = {Cardiac surgery performed with cardiopulmonary bypass carries a risk of central nervous system injury that negatively impacts the outcome of these patients. This neurogical risk most of the cases is described as ischemic injury, however it is not the only neurological complication that can be found in the postoperative period of patients undergoing cardiac surgery. Seizures also have a significant impact on morbidity and mortality and are associated with a significant increase of hospital stay. 

While ischemic events after cardiac surgery of adult patients are well characterized, we have few data on postoperative seizures of nonischemic origin. One of the theories postulated to explain these phenomena is the epileptogenic potential of antifibrinolytic drugs which are widely used in order to minimize bleeding and reduce exposure to blood products. Several reports suggest that tranexamic acid can induce seizure activity in the postoperative period. The objective of this study was to examine risk factors associated with postoperative seizures in patients undergoing cardiac surgery who received tranexamic acid.

All patients undergoing cardiac surgery with cardiopulmonary bypass between January 2008 and December 2009 were identified. Cases were defined as patients who developed seizures within 48 hours of surgery. Exclusion criteria included pre-existing epilepsy and patients in whom the convulsive episode was secondary to a new ischemic lesion on brain imaging. Controls were randomly selected from the initial cohort. 

Twenty-eight cases and 112 controls were analyzed. An association between high preoperative creatinine value and postoperative seizure was identified.},
keywords = {Cirugía cardiaca},
keywords = {Circulación extracorpórea},
keywords = {Convulsiones},
keywords = {Acido tranexámico},
title = {Factores de riesgo para convulsiones tras cirugía cardiaca con acido tranexamico: estudio de casos y controles, FCI},
publisher = {Universidad del Rosario},
keywords = {Cardiac surgery},
keywords = {Extracorporeal circulation},
keywords = {Seizures},
keywords = {Tranexamic acid},
}