@bachelorthesis{10336/9019,
author = {Sarmiento-Monroy, Juan-Camilo},
year = {2014},
month = {11},
url = {http://repository.urosario.edu.co/handle/10336/9019},
abstract = {Objective: to investigate aggregation of autoimmunity among first–degree relatives (FDR) of probands with Sjogren´s syndrome (SS) disclosing polyautoimmunity and familial autoimmunity.
Methods: this was a cross–sectional family study in which 14 families of women classified as having SS were enrolled to investigate the presence of autoimmune diseases (ADs). A genetic analysis that included recurrent risk ratios was performed. Familial aggregation was calculated for FDR taking into account the prevalence for a specific ADs in the sample and in general population.
Results: a total of 112 individuals were retrieved. The mean age was 51.7±12.9 años. 22 individuals of FDR had at least one AD (28.2%). Values supporting familial aggregation were observed for idiopathic thrombocytopenic purpura, granulomatosis with poliangiitis and antiphospholipid syndrome.
Conclusion: these results indicate that ADs cluster within families with SS and suggest a common background. The selection and study of extreme, clinically relevant phenotypes represents a novel approach for personalized medicine in autoimmunity.},
organization = {Centro de Estudio de Enfermedades Autoinmunes},
organization = {Universidad el Rosario},
keywords = {Síndrome de Sjogren},
keywords = {Agregación familiar},
keywords = {Poliautoinmunidad},
keywords = {Fenotipos extremos},
keywords = {Medicina personalizada},
title = {Agregación de autoinmunidad en familias extremas con Síndrome de Sjogren: una aproximación a la medicina personalizada},
publisher = {Universidad del Rosario},
keywords = {Sjogren´s syndrome},
keywords = {Familial aggregation},
keywords = {Polyautoimmunity},
keywords = {Extreme phenotypes},
keywords = {Personalized medicine},
doi = {https://doi.org/10.48713/10336_9019 },
}