@bachelorthesis{10336/9019, author = {Sarmiento-Monroy, Juan-Camilo}, year = {2014}, month = {11}, url = {http://repository.urosario.edu.co/handle/10336/9019}, abstract = {Objective: to investigate aggregation of autoimmunity among first–degree relatives (FDR) of probands with Sjogren´s syndrome (SS) disclosing polyautoimmunity and familial autoimmunity. Methods: this was a cross–sectional family study in which 14 families of women classified as having SS were enrolled to investigate the presence of autoimmune diseases (ADs). A genetic analysis that included recurrent risk ratios was performed. Familial aggregation was calculated for FDR taking into account the prevalence for a specific ADs in the sample and in general population. Results: a total of 112 individuals were retrieved. The mean age was 51.7±12.9 años. 22 individuals of FDR had at least one AD (28.2%). Values supporting familial aggregation were observed for idiopathic thrombocytopenic purpura, granulomatosis with poliangiitis and antiphospholipid syndrome. Conclusion: these results indicate that ADs cluster within families with SS and suggest a common background. The selection and study of extreme, clinically relevant phenotypes represents a novel approach for personalized medicine in autoimmunity.}, organization = {Centro de Estudio de Enfermedades Autoinmunes}, organization = {Universidad el Rosario}, keywords = {Síndrome de Sjogren}, keywords = {Agregación familiar}, keywords = {Poliautoinmunidad}, keywords = {Fenotipos extremos}, keywords = {Medicina personalizada}, title = {Agregación de autoinmunidad en familias extremas con Síndrome de Sjogren: una aproximación a la medicina personalizada}, publisher = {Universidad del Rosario}, keywords = {Sjogren´s syndrome}, keywords = {Familial aggregation}, keywords = {Polyautoimmunity}, keywords = {Extreme phenotypes}, keywords = {Personalized medicine}, doi = {https://doi.org/10.48713/10336_9019 }, }