TY  - JOUR
TI  - Development of a risk stratification system for the occurrence of prolonged postoperative ileus after colorectal surgery: A prospective risk factor analysis
AU  - Vather, Ryash
AU  - Josephson, Rachel
AU  - Jaung, Rebekah
AU  - Robertson, Jason
AU  - Bissett, Ian
T2  - Surgery
AB  - Background. Management strategies for prolonged postoperative ileus (PPOI) are principally conservative and it is therefore valuable to shift attention to prevention. This study aimed to identify prospectively the perioperative risk factors for the development of PPOI and create a tool to predict its occurrence.
Methods. Patients undergoing elective colorectal surgery at Auckland District Health Board between September 2012 and June 2014 were enrolled. In total, 92 variables were investigated prospectively with uniform application of a standardized definition of PPOI. Logistic regression and area under receiver operating characteristic curves (AUC) were used to generate risk stratification models.
Results. PPOI occurred in 88 of 327 patients (26.9%). Independent predictors of PPOI were male gender (odds ratio [OR], 3.01), decreasing preoperative albumin (OR, 1.11 per g/L unit), open or converted technique (OR, 6.37 [vs laparoscopic]), increasing wound size (OR, 1.09 [per cm]), operative difficulty (OR, 1.28 [per unit on 10-point Likert scale]), operative bowel handling (OR, 1.38 [per unit on 10-point Likert scale]), red cell transfusion (OR, 1.84 [per unit]), intravenous crystalloid administration (OR, 1.55 [per liter]), and delayed first mobilization (OR, 1.39 [per day]). The I-Score assimilated preoperative and intraoperative variables to generate a score out of 6 with a 7-fold increase in risk from low-risk to high-risk strata and fair predictive capacity (AUC, 0.742; 95% CI, 0.684–0.799).
Conclusion. Independent predictors for the development of PPOI have been identified prospectively and used to construct a novel risk stratification model. (Surgery 2015;157:764-73.)
DA  - 2015/04//
PY  - 2015
DO  - 10.1016/j.surg.2014.12.005
DP  - Crossref
VL  - 157
IS  - 4
SP  - 764
EP  - 773
LA  - en
SN  - 00396060
ST  - Development of a risk stratification system for the occurrence of prolonged postoperative ileus after colorectal surgery
UR  - https://linkinghub.elsevier.com/retrieve/pii/S0039606014007922
Y2  - 2018/11/02/06:31:11
ER  - 

TY  - JOUR
TI  - Factores de riesgo asociados a íleo posquirúrgico prolongado en pacientes sometidos a resección electiva de colon
AU  - Juárez-Parra, M.A.
AU  - Carmona-Cantú, J.
AU  - González-Cano, J.R.
AU  - Arana-Garza, S.
AU  - Treviño-Frutos, R.J.
T2  - Revista de Gastroenterología de México
AB  - Background: There is an inhibition of the coordinated motility of the colon after its surgical manipulation that contributes to the accumulation of fluids and gas, in turn characterized by nausea, vomiting, pain, abdominal distension, and constipation. Motility is recovered in the majority of patients within the first 72 hours. A delay in its resolution is known as prolonged postoperative ileus. Aims: To study the preoperative, intraoperative, and postoperative risk factors for developing prolonged ileus in patients that underwent elective colon resection. Materials and methods: The association between 25 perioperative variables and the presentation of prolonged ileus was analyzed in 85 patients that underwent colon resection at Hospital Christus Muguerza Alta Especialidad within the time frame of 2011 and 2014.
Results: Postoperative ileus occurred in 22.3% of the patients. The statistically significant predictors of ileus were obesity (OR 1.119, P=.048) and admission to the intensive care unit (OR 3.571, P=.050). The use of peridural anesthesia during the surgical act was found to be a protective factor (OR 0.363, P=.050).
Conclusions: The presence of these risk factors can alert the physician to the need for a closer follow-up in patients at high risk for postoperative ileus, and the use of peridural anesthesia can possibly lower the incidence of ileus.
DA  - 2015/10//
PY  - 2015
DO  - 10.1016/j.rgmx.2015.08.002
DP  - Crossref
VL  - 80
IS  - 4
SP  - 260
EP  - 266
LA  - es
SN  - 03750906
UR  - https://linkinghub.elsevier.com/retrieve/pii/S0375090615001007
Y2  - 2018/11/02/06:31:13
ER  - 

TY  - JOUR
TI  - La recuperación posoperatoria acelerada (fast track) disminuye la estancia hospitalaria en cirugía gastrointestinal alta: revisión sistemática de la literatura
AU  - Jiménez, William Andrés
AU  - Domínguez, Luis Carlos
DP  - Zotero
SP  - 9
LA  - es
ER  - 

TY  - JOUR
TI  - Postoperative ileus: Pathophysiology, incidence, and prevention
AU  - Venara, A.
AU  - Neunlist, M.
AU  - Slim, K.
AU  - Barbieux, J.
AU  - Colas, P.A.
AU  - Hamy, A.
AU  - Meurette, G.
T2  - Journal of Visceral Surgery
AB  - Postoperative ileus (POI) is a major focus of concern for surgeons because it increases duration of hospitalization, cost of care, and postoperative morbidity. The definition of POI is relatively consensual albeit with a variable definition of interval to resolution ranging from 2 to 7 days for different authors. This variation, however, leads to non-reproducibility of studies and difficulties in interpreting the results. Certain risk factors for POI, such as male gender, advanced age and major blood loss, have been repeatedly described in the literature. Understanding of the pathophysiology of POI has helped combat and prevent its occurrence. But despite preventive and therapeutic efforts arising from such knowledge, 10 to 30% of patients still develop POI after abdominal surgery. In France, pharmacological prevention is limited by the unavailability of effective drugs. Perioperative nutrition is very important, as well as limitation of preoperative fasting to 6 hours for solid food and 2 hours for liquids, and virtually no fasting in the postoperative period. Coffee and chewing gum also play a preventive role for POI. The advent of laparoscopy has led to a significant improvement in the recovery of gastrointestinal function. Enhanced recovery programs, grouping together all measures for prevention or cure of POI by addressing the mechanisms of POI, has reduced the duration of hospitalization, morbidity and interval to resumption of transit.
DA  - 2016/12//
PY  - 2016
DO  - 10.1016/j.jviscsurg.2016.08.010
DP  - Crossref
VL  - 153
IS  - 6
SP  - 439
EP  - 446
LA  - en
SN  - 18787886
ST  - Postoperative ileus
UR  - https://linkinghub.elsevier.com/retrieve/pii/S1878788616301266
Y2  - 2018/11/02/06:31:17
ER  - 

TY  - JOUR
TI  - Perioperative Factors Predicting Prolonged Postoperative Ileus After Major Abdominal Surgery
AU  - Sugawara, Kotaro
AU  - Kawaguchi, Yoshikuni
AU  - Nomura, Yukihiro
AU  - Suka, Yusuke
AU  - Kawasaki, Keishi
AU  - Uemura, Yukari
AU  - Koike, Daisuke
AU  - Nagai, Motoki
AU  - Furuya, Takatoshi
AU  - Tanaka, Nobutaka
T2  - Journal of Gastrointestinal Surgery
AB  - Background Prolonged postoperative ileus (PPOI) is among the common complications adversely affecting postoperative outcomes. Predictors of PPOI after major abdominal surgery remain unclear, although various PPOI predictors have been reported in patients undergoing colorectal surgery. This study aimed to devise a model for stratifying the probability of PPOI in patients undergoing abdominal surgery.
Methods Between 2012 and 2013, 841 patients underwent major abdominal surgery after excluding patients who underwent lessinvasive abdominal surgery, ileus-associated surgery, and emergency surgery. Postoperative managements were generally based on enhanced recovery after surgery (ERAS) program. The definition of PPOI was based on nausea, no oral diet, flatus absence, abdominal distension, and radiographic findings. A nomogram was devised by evaluating predictive factors for PPOI.
Results Of the 841 patients, 73 (8.8%) developed PPOI. Multivariable logistic regression analysis revealed smoking history (P = 0.025), colorectal surgery (P = 0.004), and an open surgical approach (P = 0.002) to all be independent predictive factors for PPOI. A nomogram was devised by employing these three significant predictive factors. The prediction model showed relatively good discrimination performance, the concordance index of which was 0.71 (95%CI 0.66–0.77). The probability of PPOI in patients with a smoking history who underwent open colorectal surgery was calculated to be 19.6%.
Conclusions Colorectal surgery, open abdominal surgery, and smoking history were found to be independent predictive factors for PPOI in patients who underwent major abdominal surgery. A nomogram based on these factors was shown to be useful for identifying patients with a high probability of developing PPOI.
DA  - 2018/03//
PY  - 2018
DO  - 10.1007/s11605-017-3622-8
DP  - Crossref
VL  - 22
IS  - 3
SP  - 508
EP  - 515
LA  - en
SN  - 1091-255X, 1873-4626
UR  - http://link.springer.com/10.1007/s11605-017-3622-8
Y2  - 2018/11/02/06:31:20
ER  - 

TY  - JOUR
TI  - Defining Postoperative Ileus: Results of a Systematic Review and Global Survey
AU  - Vather, Ryash
AU  - Trivedi, Sid
AU  - Bissett, Ian
T2  - Journal of Gastrointestinal Surgery
AB  - Background There is a lack of an internationally accepted standardised clinical definition for postoperative ileus (POI). This has made it difficult to estimate incidence and identify risk factors and has compromised external validity of clinical trials. Aim To clarify terminology of POI and propose concise, clinically quantifiable definitions.
Methods A systematic review extracted definitions from randomised trials published between 1996 and 2011 investigating POI after abdominal surgery. This was followed by a global survey seeking opinions of those who have published in the field.
Results Definitions were extracted from 52 identified trials. Responses were received in the survey from 45 of 118 corresponding authors. Data were amalgamated to synthesise the following definitions: postoperative ileus (POI) “interval from surgery until passage of flatus/stool AND tolerance of an oral diet”; prolonged POI “two or more of nausea/vomiting, inability to tolerate oral diet over 24 h, absence of flatus over 24 h, distension, radiologic confirmation occurring on or after day 4 postoperatively without prior resolution of POI”; recurrent POI “two or more of nausea/vomiting, inability to tolerate oral diet over 24 h, absence of flatus over 24 h, distension, radiologic confirmation, occurring after apparent resolution of POI”. Concordance of the latter two definitions with survey responses were ≥75 %.
Conclusion We have proposed standardised endpoints for use in future studies to facilitate objective comparison of competing interventions.
DA  - 2013/05//
PY  - 2013
DO  - 10.1007/s11605-013-2148-y
DP  - Crossref
VL  - 17
IS  - 5
SP  - 962
EP  - 972
LA  - en
SN  - 1091-255X, 1873-4626
ST  - Defining Postoperative Ileus
UR  - http://link.springer.com/10.1007/s11605-013-2148-y
Y2  - 2018/11/02/06:31:23
ER  - 

TY  - JOUR
TI  - Risk factors for prolonged ileus following colon surgery
AU  - Moghadamyeghaneh, Zhobin
AU  - Hwang, Grace S.
AU  - Hanna, Mark H.
AU  - Phelan, Michael
AU  - Carmichael, Joseph C.
AU  - Mills, Steven
AU  - Pigazzi, Alessio
AU  - Stamos, Michael J.
T2  - Surgical Endoscopy
AB  - Background Prolonged ileus is one of the most common postoperative complications after colorectal surgery. We sought to investigate the predictors of prolonged ileus following elective colon resections procedures.
DA  - 2016/02//
PY  - 2016
DO  - 10.1007/s00464-015-4247-1
DP  - Crossref
VL  - 30
IS  - 2
SP  - 603
EP  - 609
LA  - en
SN  - 0930-2794, 1432-2218
UR  - http://link.springer.com/10.1007/s00464-015-4247-1
Y2  - 2018/11/06/14:46:59
ER  - 

TY  - JOUR
TI  - Risk Factors for Prolonged Ileus After Resection of Colorectal Cancer: An Observational Study of 2400 Consecutive Patients
AU  - Chapuis, Pierre H.
AU  - Bokey, Les
AU  - Keshava, Anil
AU  - Rickard, Matthew J.F.X.
AU  - Stewart, Peter
AU  - Young, Christopher J.
AU  - Dent, Owen F.
T2  - Annals of Surgery
AB  - Objective: Prolonged ileus—the failure of postoperative ileus to resolve within a few days after major abdominal surgery—leads to significant medical consequences for the patient and costs to the hospital system. The aim of this retrospective analysis of prospectively collected data was to identify independent preoperative and intraoperative risk factors for prolonged ileus in a large consecutive series of patients who had undergone resection for colorectal cancer.
Methods: Patients were drawn from a hospital registry of 2400 consecutive resections over the period 1995–2009. Thirty-four potential predictors of prolonged ileus were analyzed by logistic regression.
Results: Prolonged ileus occurred in 14.0% of patients. Statistically significant independent predictors of prolonged ileus were male sex (OR: 1.7, P < 0.001), peripheral vascular disease (OR: 1.8, P < 0.001), respiratory comorbidity (OR: 1.6, P < 0.001), resection at urgent operation (OR: 2.2, P < 0.001), perioperative transfusion (OR: 1.6, P < 0.010), stoma constructed (OR: 1.4, P < 0.001), and operation lasting ≥3 hours (OR: 1.6, P < 0.001).
Conclusions: These features can be used to alert medical and nursing staff to patients likely to experience prolonged ileus after bowel resection so that they can be monitored closely in the postoperative period and available treatments targeted toward them. These features may also be useful in the research context to facilitate the more efficient selection of high-risk patients as subjects in clinical trials of prevention or treatment.
DA  - 2013/05//
PY  - 2013
DO  - 10.1097/SLA.0b013e318268a693
DP  - Crossref
VL  - 257
IS  - 5
SP  - 909
EP  - 915
LA  - en
SN  - 0003-4932
ST  - Risk Factors for Prolonged Ileus After Resection of Colorectal Cancer
UR  - http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:landingpage&an=00000658-201305000-00019
Y2  - 2018/11/06/14:47:01
ER  - 

TY  - JOUR
TI  - Management of Postoperative Ileus
AU  - Thompson, Melissa
AU  - Magnuson, Barbara
T2  - Orthopedics
A2  - Smith, Kelly M.
AB  - Postoperative ileus, a temporary cessation in bowel motility, is a common and significant complication of major surgery. Consequences of postoperative ileus include increased patient discomfort, delayed time to adequate nutrition, prolonged length of stay, and increased cost to the patient and healthcare system. The traditional, multi-modal approach to the resolution of postoperative ileus includes opioid minimization, early ambulation, and early feeding. Newer medications, such as methlynaltrexone and alvimopan (which are peripherally acting mu opioid receptor antagonists), have become available and have proven beneficial for use with postoperative ileus.
DA  - 2012/03/01/
PY  - 2012
DO  - 10.3928/01477447-20120222-08
DP  - Crossref
VL  - 35
IS  - 3
SP  - 213
EP  - 217
LA  - en
SN  - 0147-7447
UR  - http://www.slackinc.com/doi/resolver.asp?doi=10.3928/01477447-20120222-08
Y2  - 2018/11/06/14:47:04
ER  - 

TY  - JOUR
TI  - Beneficial Effects of Early Enteral Nutrition After Major Rectal Surgery: A Possible Role for Conditionally Essential Amino Acids? Results of a Randomized Clinical Trial
AU  - van Barneveld, Kevin W. Y.
AU  - Smeets, Boudewijn J. J.
AU  - Heesakkers, Fanny F. B. M.
AU  - Bosmans, Joanna W. A. M.
AU  - Luyer, Misha D.
AU  - Wasowicz, Dareczka
AU  - Bakker, Jaap A.
AU  - Roos, Arnout N.
AU  - Rutten, Harm J. T.
AU  - Bouvy, Nicole D.
AU  - Boelens, Petra G.
T2  - Critical Care Medicine
DA  - 2016/06//
PY  - 2016
DO  - 10.1097/CCM.0000000000001640
DP  - Crossref
VL  - 44
IS  - 6
SP  - e353
EP  - e361
LA  - en
SN  - 0090-3493
ST  - Beneficial Effects of Early Enteral Nutrition After Major Rectal Surgery
UR  - http://Insights.ovid.com/crossref?an=00003246-201606000-00049
Y2  - 2018/11/06/14:47:06
ER  - 

TY  - BOOK
TI  - Schwartz principios de cirugía
AU  - Schwartz, Seymour I
AU  - Brunicardi, F. Charles
AU  - Araiza Martínez, Martha Elena
AU  - Arias Rebatet, Germán
CY  - México; Bogota
DA  - 2011///
PY  - 2011
DP  - Open WorldCat
LA  - es
PB  - McGraw-Hill Interamericana Editores
SN  - 978-607-15-0413-5
ER  - 

TY  - JOUR
TI  - Risk factors for postoperative ileus following elective laparoscopic right colectomy: a retrospective multicentric study
AU  - Courtot, Lise
AU  - Le Roy, Bertrand
AU  - Memeo, Ricardo
AU  - Voron, Thibault
AU  - de Angelis, Nicolas
AU  - Tabchouri, Nicolas
AU  - Brunetti, Francesco
AU  - Berger, Anne
AU  - Mutter, Didier
AU  - Gagniere, Johan
AU  - Salamé, Ephrem
AU  - Pezet, Denis
AU  - Ouaïssi, Mehdi
T2  - International Journal of Colorectal Disease
AB  - Purpose Postoperative ileus (POI) is associated with an elevated risk of other complications and increases the economic impact on healthcare services. The aim of this study was to identify pre-, intra- and postoperative risk factors associated with the development of POI following elective laparoscopic right colectomy.
Methods Between 2004 and 2016, 637 laparoscopic right colectomies were performed. Data were analysed retrospectively thanks to the CLIHMET database. Potential contributing factors were analysed by logistic regression.
Results Patients with POI (n = 113, 17.7%) were compared to those without postoperative ileus (WPOI) (n = 524, 82.3%). In the POI group, there were more men (62 vs 49%; p = 0.012), more use of epidural anaesthesia (19 vs 9%; p = 0.004), more intraoperative blood transfusion requirements (7 vs 3%; p = 0.018) and greater perioperative intravenous fluid administration (2000 vs 1750 mL; p < 0.001). POIs were more frequent when extracorporeal vascular section (20 vs 12%; p = 0.049) and transversal incision for extraction site (34 vs 23%; p = 0.044) were performed. Overall surgical complications in the POI group were significantly greater than in the control group WPOI (31.9 vs 12.0%; p < 0.0001). Multivariate analysis found the following independent POI risk factors: male gender (HR = 2.316, 1.102–4.866), epidural anaesthesia (HR = 2.958, 1.250–6.988) and postoperative blood transfusion requirement (HR = 6.994, 1.550–31.560).
Conclusions This study is one of the first to explore the CLIHMET database and the first to use it for investigating risk factors for POI development. Modifiable risk factors such as epidural anaesthesia and intraoperative blood transfusion should be used with caution in order to decrease POI rates.
DA  - 2018/10//
PY  - 2018
DO  - 10.1007/s00384-018-3070-2
DP  - Crossref
VL  - 33
IS  - 10
SP  - 1373
EP  - 1382
LA  - en
SN  - 0179-1958, 1432-1262
ST  - Risk factors for postoperative ileus following elective laparoscopic right colectomy
UR  - http://link.springer.com/10.1007/s00384-018-3070-2
Y2  - 2018/11/06/15:01:18
ER  - 

TY  - JOUR
TI  - Postoperative ileus: Etiologies and interventions
AU  - Behm, Brian
AU  - Stollman, Neil
T2  - Clinical Gastroenterology and Hepatology
DA  - 2003/03//
PY  - 2003
DO  - 10.1053/cgh.2003.50012
DP  - Crossref
VL  - 1
IS  - 2
SP  - 71
EP  - 80
LA  - en
SN  - 15423565
ST  - Postoperative ileus
UR  - http://linkinghub.elsevier.com/retrieve/pii/S1542356503700160
Y2  - 2018/11/06/15:01:22
ER  - 

TY  - JOUR
TI  - Deflating postoperative ileus
AU  - Prasad, Madhu
AU  - Matthews, Jeffrey B.
T2  - Gastroenterology
DA  - 1999/08/01/
PY  - 1999
DO  - 10.1053/gast.1999.0029900489
DP  - www.gastrojournal.org
VL  - 117
IS  - 2
SP  - 489
EP  - 492
J2  - Gastroenterology
LA  - English
SN  - 0016-5085, 1528-0012
UR  - https://www.gastrojournal.org/article/S0016-5085(99)00179-1/fulltext
Y2  - 2018/11/06/15:08:54
L2  - http://www.ncbi.nlm.nih.gov/pubmed/10419931
L2  - https://www.gastrojournal.org/article/S0016-5085(99)00179-1/fulltext
L4  - http://www.gastrojournal.org/article/S0016508599001791/pdf
ER  - 

TY  - JOUR
TI  - ¿Podemos predecir el íleo postoperatorio tras cistectomía radical?
AU  - Senarriaga Ruiz De La Illa, N.
AU  - Rábade Ferreiro, A.
AU  - Loizaga Iriarte, A.
AU  - Lacasa Viscasillas, I.
AU  - Arciniega García, J. M.
AU  - Unda Urzaiz, M.
T2  - Actas Urológicas Españolas
DA  - 2010/08//
PY  - 2010
DP  - SciELO
VL  - 34
IS  - 7
SP  - 630
EP  - 633
SN  - 0210-4806
UR  - http://scielo.isciii.es/scielo.php?script=sci_abstract&pid=S0210-48062010000700010&lng=es&nrm=iso&tlng=es
Y2  - 2018/11/06/18:51:02
L2  - http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S0210-48062010000700010
L4  - http://scielo.isciii.es/pdf/aue/v34n7/breve2.pdf
ER  - 

TY  - JOUR
TI  - Postoperative ileus: Recent developments in pathophysiology and management
AU  - Bragg, Damian
AU  - El-Sharkawy, Ahmed M.
AU  - Psaltis, Emmanouil
AU  - Maxwell-Armstrong, Charles A.
AU  - Lobo, Dileep N.
T2  - Clinical Nutrition
AB  - Background & aims: Postoperative ileus (POI) is a frequent occurrence after abdominal and other types of surgery, and is associated with significant morbidity and costs to health care providers. The aims of this narrative review were to provide an update of classification systems, preventive techniques, pathophysiological mechanisms, and treatment options for established POI.
Methods: The Web of Science, MEDLINE, PubMed and Google Scholar databases were searched using the key phrases ‘ileus’, ‘postoperative ileus’ and ‘definition’, for relevant studies published in English from January 1997 to August 2014.
Results: POI is still a problematic and frequent complication of surgery. Fluid overload, exogenous opioids, neurohormonal dysfunction, and gastrointestinal stretch and inflammation are key mechanisms in the pathophysiology of POI. Evidence is supportive of thoracic epidural analgesia, avoidance of salt and water overload, alvimopan and gum chewing as measures for the prevention of POI, and should be incorporated into perioperative care protocols. Minimal access surgery and avoidance of nasogastric tubes may also help. Novel strategies are emerging, but further studies are required for the treatment of prolonged POI, where evidence is still lacking.
Conclusions: Although POI is often inevitable, methods to reduce its duration and facilitate recovery of postoperative gastrointestinal function are evolving rapidly. Utilisation of standardised diagnostic classification systems will help improve applicability of future studies.
DA  - 2015/06//
PY  - 2015
DO  - 10.1016/j.clnu.2015.01.016
DP  - Crossref
VL  - 34
IS  - 3
SP  - 367
EP  - 376
LA  - en
SN  - 02615614
ST  - Postoperative ileus
UR  - https://linkinghub.elsevier.com/retrieve/pii/S0261561415000382
Y2  - 2019/04/26/21:39:47
ER  - 

TY  - CHAP
TI  - Postoperative Ileus: Pathophysiology, Current Therapeutic Approaches
AU  - Stakenborg, N.
AU  - Gomez-Pinilla, P. J.
AU  - Boeckxstaens, G. E.
T2  - Gastrointestinal Pharmacology
A2  - Greenwood-Van Meerveld, Beverley
CY  - Cham
DA  - 2016///
PY  - 2016
DP  - Crossref
VL  - 239
SP  - 39
EP  - 57
LA  - en
PB  - Springer International Publishing
SN  - 978-3-319-56359-6 978-3-319-56360-2
ST  - Postoperative Ileus
UR  - http://link.springer.com/10.1007/164_2016_108
Y2  - 2019/10/26/05:31:17
ER  - 

TY  - JOUR
TI  - Incidence and Risk Factors for Severity of Postoperative Ileus After Colorectal Surgery: A Prospective Registry Data Analysis
AU  - the GRACE Collaborative Group For Ileus Study
AU  - Venara, A.
AU  - Meillat, H.
AU  - Cotte, E.
AU  - Ouaissi, M.
AU  - Duchalais, E.
AU  - Mor-Martinez, C.
AU  - Wolthuis, A.
AU  - Regimbeau, J. M.
AU  - Ostermann, S.
AU  - Hamel, J. F.
AU  - Joris, J.
AU  - Slim, K.
T2  - World Journal of Surgery
AB  - Background Defining severe postoperative ileus in terms of consequences could help physicians standardize the management of this condition. The recently described classification based on consequences requires further investigation. The aim of this study was to obtain a snapshot of postoperative ileus in patients undergoing colorectal surgery within enhanced recovery programs and to identify factors associated with non-severe and severe postoperative ileus.
Methods This prospective registry data analysis was conducted in 40 centers in five different countries. A total of 786 patients scheduled for colorectal surgery within enhanced recovery programs were included. The primary endpoint was the incidence rate of postoperative ileus as defined by Vather et al.
Results A total of 121 patients experienced postoperative ileus (15.4%). Non-severe POI occurred in 48 patients (6.1%), and severe postoperative ileus occurred in 73 patients (9.3%). In multivariate analysis, the male gender and intra-abdominal complications were associated with severe postoperative ileus: odd ratio (OR) = 2.03 [95% confidence interval (CI) 1.14–3.59], p = 0.01 and OR = 3.60 [95% CI 1.75–7.40], p \ 0.0001, respectively. Conversely, open laparotomy and urinary retention were associated with non-severe POI: OR = 3.03 [95% CI 1.37–6.72], p = 0.006 and OR = 2.70 [95% CI 0.89–8.23], p = 0.08, respectively.
Conclusions Postoperative ileus occurred in 15% of patients after colorectal surgery within enhanced recovery programs. For 60% of patients, this was considered severe. The physiopathology of these two entities could be different, severe POI being linked to intraabdominal complication, while non-severe POI being linked with risk factors for ‘‘primary’’ POI. The physician should pay attention to male patients having POI after colorectal surgery and look for features evocating intraabdominal complications.
DA  - 2019/11/12/
PY  - 2019
DO  - 10.1007/s00268-019-05278-3
DP  - DOI.org (Crossref)
J2  - World J Surg
LA  - en
SN  - 0364-2313, 1432-2323
ST  - Incidence and Risk Factors for Severity of Postoperative Ileus After Colorectal Surgery
UR  - http://link.springer.com/10.1007/s00268-019-05278-3
Y2  - 2020/02/13/15:19:01
ER  - 

TY  - JOUR
TI  - Proposal of a new classification of postoperative ileus based on its clinical impact—results of a global survey and preliminary evaluation in colorectal surgery
AU  - Venara, Aurélien
AU  - Slim, Karem
AU  - Regimbeau, Jean-Marc
AU  - Ortega-Deballon, Pablo
AU  - Vielle, Bruno
AU  - Lermite, Emilie
AU  - Meurette, Guillaume
AU  - Hamy, Antoine
T2  - International Journal of Colorectal Disease
AB  - Purpose There is no consensual definition of postoperative ileus (POI), which leads to a lack of reproducibility. The aims of this study were (i) to propose and evaluate a classification of postoperative ileus based on its consequences and (ii) to assess the reproducibility of the classification.
DA  - 2017/06//
PY  - 2017
DO  - 10.1007/s00384-017-2788-6
DP  - DOI.org (Crossref)
VL  - 32
IS  - 6
SP  - 797
EP  - 803
J2  - Int J Colorectal Dis
LA  - en
SN  - 0179-1958, 1432-1262
UR  - http://link.springer.com/10.1007/s00384-017-2788-6
Y2  - 2020/03/03/22:05:39
ER  - 

TY  - JOUR
TI  - ESTANCIA HOSPITALARIA Y COMPLICACIONES EN PACIENTES DE CIRUGÍA COLO-RECTAL TRAS LA IMPLEMENTACIÓN DEL PROTOCOLO ERAS. CLÍNICA REINA SOFÍA, BOGOTÁ 2015 - 2018
AU  - Patiño, David Alejandro Mayo
AU  - Navas, Gabriela Acosta
DP  - Zotero
SP  - 62
LA  - es
ER  - 

TY  - JOUR
TI  - Caracterización de pacientes intervenidos quirúrgicamente por patología Oncológica colorectal en hospital universitario mayor Mederi 2013 - 2017
AU  - Sánchez, Julián Andrés Romo
DA  - 2013///
PY  - 2013
DP  - Zotero
SP  - 60
LA  - es
ER  - 

TY  - JOUR
TI  - Postoperative ileus following major colorectal surgery: Postoperative ileus following major colorectal surgery
AU  - Chapman, S. J.
AU  - Pericleous, A.
AU  - Downey, C.
AU  - Jayne, D. G.
T2  - British Journal of Surgery
AB  - Background: Postoperative ileus (POI) is characterized by delayed gastrointestinal recovery following surgery. Current knowledge of pathophysiology, clinical interventions and methodological challenges was reviewed to inform modern practice and future research.
Methods: A systematic search of MEDLINE and Embase databases was performed using search terms related to ileus and colorectal surgery. All RCTs involving an intervention to prevent or reduce POI published between 1990 and 2016 were identified. Grey literature, non-full-text manuscripts, and reanalyses of previous RCTs were excluded. Eligible articles were assessed using the Cochrane tool for assessing risk of bias.
Results: Of 5614 studies screened, 86 eligible articles describing 88 RCTs were identified. Current knowledge of pathophysiology acknowledges neurogenic, inflammatory and pharmacological mechanisms, but much of the evidence arises from animal studies. The most common interventions tested were chewing gum (11 trials) and early enteral feeding (11), which are safe but of unclear benefit for actively reducing POI. Others, including thoracic epidural analgesia (8), systemic lidocaine (8) and peripheral ������ antagonists (5), show benefit but require further investigation for safety and cost-effectiveness.
Conclusion: POI is a common condition with no established definition, aetiology or treatment. According to current literature, minimally invasive surgery, protocol-driven recovery (including early feeding and opioid avoidance strategies) and measures to avoid major inflammatory events (such as anastomotic leak) offer the best chances of reducing POI.
DA  - 2018/06//
PY  - 2018
DO  - 10.1002/bjs.10781
DP  - DOI.org (Crossref)
VL  - 105
IS  - 7
SP  - 797
EP  - 810
J2  - Br J Surg
LA  - en
SN  - 00071323
ST  - Postoperative ileus following major colorectal surgery
UR  - http://doi.wiley.com/10.1002/bjs.10781
Y2  - 2020/07/08/21:46:01
ER  - 

TY  - CHAP
TI  - Postoperative Ileus: Prevention and Treatment
AU  - Hübner, Martin
AU  - Scott, Michael
AU  - Champagne, Bradley
T2  - The SAGES / ERAS® Society Manual of Enhanced Recovery Programs for Gastrointestinal Surgery
A2  - Feldman, Liane S.
A2  - Delaney, Conor P.
A2  - Ljungqvist, Olle
A2  - Carli, Francesco
CY  - Cham
DA  - 2015///
PY  - 2015
DP  - DOI.org (Crossref)
SP  - 133
EP  - 146
LA  - en
PB  - Springer International Publishing
SN  - 978-3-319-20363-8 978-3-319-20364-5
ST  - Postoperative Ileus
UR  - http://link.springer.com/10.1007/978-3-319-20364-5_12
Y2  - 2020/07/08/21:54:59
ER  - 

TY  - JOUR
TI  - Safety and efficacy of non‐steroidal anti‐inflammatory drugs to reduce ileus after colorectal surgery
AU  - EuroSurg Collaborative
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AU  - Pruijssers, Sr
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AU  - Gordinou de Gouberville, Mc
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AU  - Hoeks, Em
AU  - Nieuwenhuizen, S
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AU  - Westerduin, E
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AU  - Penningnieuwland, G
AU  - Ruiter, A
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AU  - Tulek, Ms
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AU  - Kocak, S
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AU  - Feenstra, T
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AU  - Romaen, I
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AU  - Correia, D
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AU  - Moinhos, T
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AU  - Galvão, D
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AU  - Bettencourt, R
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AU  - Morgado, J
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AU  - Mónica, I
AU  - Oliveira, S
AU  - Ribeiro, H
AU  - Ferreira, M
AU  - Guimarães, N
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AU  - Martins, Sf
AU  - Almeida, Mr
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AU  - Faustino, A
AU  - Medeiros, N
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AU  - Resendes, M
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AU  - Cruz, A
AU  - Claro, M
AU  - Vaz Pinto, G
AU  - Sousa, D
AU  - Costa Santos, D
AU  - Silva, A
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AU  - Fialho, G
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AU  - Costa, C
AU  - Costa, J
AU  - Morais, S
AU  - Machado, A
AU  - Horta, V
AU  - Rocha‐Melo, M
AU  - Patrício, J
AU  - Pereira, M
AU  - Lima, R
AU  - Cinza, Am
AU  - Oliveira, J
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AU  - Kraria, L
AU  - Skan, O
AU  - Kind, C
AU  - Findlay, Jm
AU  - Tupper, P
AU  - Van Rhee, C
AU  - Honeyman, Si
AU  - Menon, G
AU  - Ahmed, M
AU  - Jegatheeswaran, L
AU  - Griffiths, N
AU  - Madhavan, A
AU  - Warne, M
AU  - Malcolm, Fl
AU  - Lessware, T
AU  - Wilkerson, Ht
AU  - Chatterjee‐Woolman, S
AU  - Yoong, A
AU  - Ahmed, Wur
AU  - Longshaw, A
AU  - Flannery, O
AU  - Green, R
AU  - Leaning, M
AU  - Cragg, J
AU  - Sharriff, H
AU  - Doherty, C
AU  - Ganesananthan, S
AU  - Kwan, Kwl
AU  - Sanders‐Crook, L
AU  - Bhatia, S
AU  - Eames, S
AU  - Lewis, F
AU  - Kirupananthan, P
AU  - Boh, Zy
AU  - Dass, S
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AU  - Hill, M
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AU  - Chong, Jt
AU  - Poustie, M
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AU  - Chaudhury, N
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AU  - Akbar, Z
AU  - Walters, B
AU  - Kulendrarajah, B
AU  - Tran, N
AU  - Shrestha, S
AU  - Parmar, S
AU  - Gallagher, C
AU  - Hennessy, L
AU  - Pentti, E
AU  - Badhrinarayanan, S
AU  - Fung, A
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AU  - Kenny, R
AU  - Kan, P
AU  - Lee, De
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AU  - Aftab, R
AU  - Gough, M
AU  - Woodburn, B
AU  - Vayalapra, S
AU  - McMurrugh, K
AU  - Wong, C
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AU  - Embury‐Young, Y
AU  - Turner, T
AU  - Patel, M
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AU  - Ruparelia, A
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AU  - Soare, C
AU  - Pang, Yl
AU  - Trotter, J
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AU  - Pulickal, P
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AU  - Khan, H
AU  - Lennock, S
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AU  - Pyc, W
AU  - Brignall, R
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AU  - Gadhvi, A
AU  - Grant, R
AU  - Lewsey, J
AU  - Morris, A
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AU  - McClarty, C
AU  - Sanyal, S
AU  - Alsaif, A
AU  - Palkhi, A
AU  - Bhopal, S
AU  - Vishnu K, S
AU  - Papanikolaou, A
AU  - Mitra, A
AU  - Nur, A
AU  - Ali, F
AU  - Burford, C
AU  - Huq, T
AU  - Sloper, W
AU  - Irwin, E
AU  - Matthews, L
AU  - Ngu, Ws
AU  - Hosfield, T
AU  - Muneeb, F
AU  - Page, O
AU  - Zeb, E
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AU  - Al‐Azzawi, A
AU  - McIntosh, J
AU  - Vucicevic, A
AU  - Hughes, M
AU  - Brooks, L
AU  - Fanibi, B
AU  - Dixon, M
AU  - Njoku, P
AU  - Morris, D
AU  - Jobson, J
AU  - Chowdhury, H
AU  - Alawode, Dot
AU  - Wynell‐Mayow, W
AU  - Udayachandran, V
AU  - Alsoof, D
AU  - Ekert, J
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AU  - Wright, O
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AU  - Dworkin, A
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AU  - Palmer, A
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AU  - Jones, Cj
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AU  - Erotocritou, M
AU  - Wong, J
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AU  - Ibrahim, A
AU  - Kler, A
AU  - Reynolds, L
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AU  - Majeed, Y
AU  - Fakim, B
AU  - Jones, A
AU  - Kowal, M
AU  - Liversedge, G
AU  - Carrington, Z
AU  - Windebank, J
AU  - Izzarina, A
AU  - Akbani, U
AU  - Craven, J
AU  - Aldarragi, A
AU  - Harding, S
AU  - Millward, A
AU  - Shortland, Tc
AU  - Bedford, M
AU  - Stroud, R
AU  - Obukofe, R
AU  - Mackenzie, E
AU  - Gopalan, V
AU  - Midgen, A
AU  - Khadka, P
AU  - Cheng, O
AU  - Taneja, S
AU  - Manobharath, N
AU  - Kok, Jy
AU  - Lim, Dwe
AU  - Buick, T
AU  - Boland, M
AU  - Piya, S
AU  - Devlin, R
AU  - Fairfield, Cj
AU  - George, Rj
AU  - Rahi, M
AU  - Zaman, S
AU  - Hajiev, S
AU  - Ross, T
AU  - Owen, M
AU  - Crisp, E
AU  - Thompson, C
AU  - Charalambous, A
AU  - Hollywood, Jl
AU  - Saiyed, A
AU  - Hammond, Rfl
AU  - Matthews, J
AU  - Mendonca, V
AU  - Spinty, J
AU  - Khan, K
AU  - Cheng, J
AU  - Glynn, N
AU  - Muhammad, U
AU  - Khan, M
AU  - Anderson, L
AU  - Mccormack, K
AU  - Mak, J
AU  - Patrawala, S
AU  - Milinkovic, N
AU  - Schofield, R
AU  - Chauhan, M
AU  - Hartley, L
AU  - Hind, J
AU  - Ashworth, I
AU  - Nelson, L
AU  - Ratnasingham, D
AU  - Akbari, K
AU  - Whitehead, T
AU  - Dimitriadis, S
AU  - Marshall, K
AU  - Flint, Ej
AU  - Curran, M
AU  - Horner, C
AU  - Heybourne, A
AU  - Morgan, H
AU  - Wickstone, C
AU  - Panagiotou, D
AU  - O'Connell, E
AU  - Dean, K
AU  - Iqbal, R
AU  - Walsh, L
AU  - Yu, N
AU  - Rana, N
AU  - Massie, E
AU  - Ng, J
AU  - Jung, M
AU  - Lee, Yd
AU  - Harris, M
AU  - White, S
AU  - Delibegovic, S
AU  - Boev, B
AU  - Tonchev, P
AU  - Prochazka, V
AU  - Örhalmi, J
AU  - Riško, J
AU  - Skalický, A
AU  - Chrz, K
AU  - Ravn, S
AU  - Ojakäär, A
AU  - Duchalais, E
AU  - Dörr‐Harim, C
AU  - Herrle, F
AU  - Koutserimpas, C
AU  - Giraudo, G
AU  - Armellini, A
AU  - Ruzzenente, A
AU  - Mazzeo, C
AU  - De Padua, C
AU  - Realis Luc, A
AU  - Maroli, A
AU  - Giani, I
AU  - Cufari, Me
AU  - Vitali, M
AU  - Ceccarelli, G
AU  - Gusai, Gp
AU  - Quattromani, R
AU  - Virgilio, E
AU  - Berti, S
AU  - Mulas, S
AU  - Di Mola, Ff
AU  - Papagni, V
AU  - Tuminello, F
AU  - Magnoli, M
AU  - Vittori, L
AU  - Longheu, A
AU  - Loche, Ga
AU  - Braccio, B
AU  - De Luca, E
AU  - Resta, G
AU  - Ancans, G
AU  - Tamosiunas, A
AU  - Petrulionis, M
AU  - Andrejevic, P
AU  - Stellingwerf, Me
AU  - Abdulrahman, N
AU  - Pas, Kgh
AU  - Thomas, G
AU  - Brandsma, Am
AU  - Davids, J
AU  - Rottier, Sj
AU  - Roy van Zuidewijn, D
AU  - Hawkins, R
AU  - Ong, Hi
AU  - Li, Y
AU  - Desmond, B
AU  - Winstanley, J
AU  - Martins, M
AU  - Rosete, M
AU  - Americano, M
AU  - Santos, M
AU  - Frade, S
AU  - Senhorinho, R
AU  - Peixoto, R
AU  - Alagoa João, A
AU  - Alves‐Vale, C
AU  - Lamas, M
AU  - O'Connor, Db
AU  - Hoo, M
AU  - Gopaul, A
AU  - Scanlon, K
AU  - O'Dwyer, N
AU  - Negoi, I
AU  - Jovanović, M
AU  - Panyko, A
AU  - De Lima, H
AU  - Van Vuuren, S
AU  - Curchod, P
AU  - Gaspar, S
AU  - Imadalou, L
AU  - Mutlu, D
AU  - Akyol, C
AU  - Uygur, Fa
AU  - Eray, Ic
AU  - Biyiklioglu, O
AU  - Çetin, Mf
AU  - Isik, Ae
AU  - Karip, B
AU  - Dogan, H
AU  - Sarıgül, L
AU  - Tunc, E
AU  - Aydin, T
AU  - Bodur, S
AU  - Karabulut, K
AU  - Francis, Aa
AU  - Al‐hadithi, A
AU  - To, N
AU  - Lau, Isf
AU  - Smith, E
AU  - Mahapatra, S
AU  - McAuliffe, O
AU  - Francis, Aa
AU  - Imam, L
AU  - Akram, B
AU  - Hossaini, S
AU  - Davies, R
AU  - Ko, M
AU  - Collins, J
AU  - Pandya, A
AU  - Reilly, S
AU  - Archer, J
AU  - Auty, C
AU  - Roche, Cd
AU  - Livie, J
AU  - Chaudhry, Fa
AU  - Ntakomyti, E
AU  - Diallo, R
AU  - Bylinski, T
AU  - Wright, J
AU  - Lawday, S
AU  - Masiha, E
AU  - Tung, J
AU  - Shirazi, B
AU  - Neilson, A
AU  - Epton, S
AU  - Patel, N
AU  - Trussell, S
AU  - Couldrey, A
AU  - Donnelly, C
AU  - Eftychiou, S
T2  - BJS
AB  - Background: Ileus is common after elective colorectal surgery, and is associated with increased adverse events and prolonged hospital stay. The aim was to assess the role of non-steroidal anti-inflammatory drugs (NSAIDs) for reducing ileus after surgery.
Methods: A prospective multicentre cohort study was delivered by an international, student- and trainee-led collaborative group. Adult patients undergoing elective colorectal resection between January and April 2018 were included. The primary outcome was time to gastrointestinal recovery, measured using a composite measure of bowel function and tolerance to oral intake. The impact of NSAIDs was explored using Cox regression analyses, including the results of a centre-specific survey of compliance to enhanced recovery principles. Secondary safety outcomes included anastomotic leak rate and acute kidney injury.
Results: A total of 4164 patients were included, with a median age of 68 (i.q.r. 57–75) years (54⋅9 per cent men). Some 1153 (27⋅7 per cent) received NSAIDs on postoperative days 1–3, of whom 1061 (92⋅0 per cent) received non-selective cyclo-oxygenase inhibitors. After adjustment for baseline differences, the mean time to gastrointestinal recovery did not differ significantly between patients who received NSAIDs and those who did not (4⋅6 versus 4⋅8 days; hazard ratio 1⋅04, 95 per cent c.i. 0⋅96 to 1⋅12; P = 0⋅360). There were no significant differences in anastomotic leak rate (5⋅4 versus 4⋅6 per cent; P = 0⋅349) or acute kidney injury (14⋅3 versus 13⋅8 per cent; P = 0⋅666) between the groups. Significantly fewer patients receiving NSAIDs required strong opioid analgesia (35⋅3 versus 56⋅7 per cent; P < 0⋅001).
Conclusion: NSAIDs did not reduce the time for gastrointestinal recovery after colorectal surgery, but they were safe and associated with reduced postoperative opioid requirement. ∗Members of the EuroSurg Collaborative are co-authors of this study and are listed in Appendix S1 (supporting information)
DA  - 2019/10/09/
PY  - 2019
DO  - 10.1002/bjs.11326
DP  - DOI.org (Crossref)
SP  - bjs.11326
J2  - Br J Surg
LA  - en
SN  - 0007-1323, 1365-2168
UR  - https://onlinelibrary.wiley.com/doi/abs/10.1002/bjs.11326
Y2  - 2020/07/08/23:14:48
ER  - 

TY  - JOUR
TI  - Prolonged Postoperative Ileus Significantly Increases the Cost of Inpatient Stay for Patients Undergoing Elective Colorectal Surgery: Results of a Multivariate Analysis of Prospective Data at a Single Institution
AU  - Mao, Howe
AU  - Milne, Tony G.E.
AU  - O’Grady, Gregory
AU  - Vather, Ryash
AU  - Edlin, Richard
AU  - Bissett, Ian
T2  - Diseases of the Colon & Rectum
DA  - 2019/05//
PY  - 2019
DO  - 10.1097/DCR.0000000000001301
DP  - DOI.org (Crossref)
VL  - 62
IS  - 5
SP  - 631
EP  - 637
J2  - Diseases of the Colon & Rectum
LA  - en
SN  - 0012-3706
ST  - Prolonged Postoperative Ileus Significantly Increases the Cost of Inpatient Stay for Patients Undergoing Elective Colorectal Surgery
UR  - http://journals.lww.com/00003453-201905000-00018
Y2  - 2020/07/09/04:50:39
ER  - 

TY  - JOUR
TI  - Nomogram-Derived Prediction of Postoperative Ileus after Colectomy: An Assessment from Nationwide Procedure-Targeted Cohort
AU  - Rencuzogullari, Ahmet
AU  - Benlice, Cigdem
AU  - Costedio, Meagan
AU  - Remzi, Feza H.
AU  - Gorgun, Emre
T2  - The American Surgeon
AB  - Postoperative ileus (POI) is a clinical burden to health-care system. This study aims to evaluate the incidence and predictors of POI in patients undergoing colectomy and create a nomogram by using recently released procedure-targeted nationwide database. Patients who underwent elective colectomy in 2012 and 2013 were identified from American College of Surgeons National Surgical Quality Improvement Program using the new procedure-targeted database. Demographics, comorbidities, and 30-day postoperative outcomes were evaluated. Variables in the final step-wise multiple logistic regression model for each outcome were selected in a stepwise fashion using Akaike's information criterion. A nomogram was created to aid in the calculation of POI risk for individual patients. A total of 29,201 patients met the inclusion criteria; 3834 (13.1%) developed POI with a male predominance (55.9%). Patients who developed ileus had longer length of hospital stay (11 vs 5 days; P < 0.001) and operative time (200 vs 174 minutes; P < 0.001). In the stepwise logistic regression model, the following variables were found to be independent risk factors for POI: older age (P < 0.001), male gender (P < 0.001), American Society of Anesthesiologists class III/IV (P < 0.001), open approach (P < 0.001), preoperative septic conditions (P < 0.001), omission of oral antibiotic before surgery (P < 0.001), right colectomy or total colectomy vs other procedures (P < 0.001), smoking (P = 0.001), decreased preoperative serum albumin level (P < 0.001), and prolonged operating time (P < 0.001). All postoperative complications were more frequently occurred in patients with POI. The nomogram accurately predicted POI with a concordant index for this model of 0.69. The use of minimal invasive techniques, control of preoperative septic conditions, oral antibiotic bowel preparation and shorter operative time are associated with a decreased rate of POI. External validation is essential for the confirmation and further evaluation of our logistic regression model and nomogram.
DA  - 2017/06//
PY  - 2017
DO  - 10.1177/000313481708300620
DP  - DOI.org (Crossref)
VL  - 83
IS  - 6
SP  - 564
EP  - 572
J2  - The American Surgeon
LA  - en
SN  - 0003-1348, 1555-9823
ST  - Nomogram-Derived Prediction of Postoperative Ileus after Colectomy
UR  - http://journals.sagepub.com/doi/10.1177/000313481708300620
Y2  - 2022/01/31/
ER  - 

TY  - JOUR
TI  - The role of nasogastric tube in decompression after elective colon and rectum surgery : a meta-analysis
AU  - Rao, Wensheng
AU  - Zhang, Xue
AU  - Zhang, Jian
AU  - Yan, Ronglin
AU  - Hu, Zhiqian
AU  - Wang, Qiang
T2  - International Journal of Colorectal Disease
AB  - Objectives Nasogastric tubes (NGT) have been routinely used after abdominal procedures, largely due to the accepted tradition, especially in China. However, studies recently questioned the role of routine NGT intubation by stating that it was overused and many complications occurred from its use.
DA  - 2011/04//
PY  - 2011
DO  - 10.1007/s00384-010-1093-4
DP  - DOI.org (Crossref)
VL  - 26
IS  - 4
SP  - 423
EP  - 429
J2  - Int J Colorectal Dis
LA  - en
SN  - 0179-1958, 1432-1262
ST  - The role of nasogastric tube in decompression after elective colon and rectum surgery
UR  - http://link.springer.com/10.1007/s00384-010-1093-4
Y2  - 2022/02/01/16:08:03
ER  - 

TY  - JOUR
TI  - Primary Surgery for Malignant Large Bowel Obstruction: Postoperative Nasogastric Tube Reinsertion is Not Mandatory
AU  - Venara, A.
AU  - Barbieux, J.
AU  - Colas, P. A.
AU  - Le Fouler, A.
AU  - Lermite, E.
AU  - Hamy, A.
T2  - World Journal of Surgery
AB  - Background Malignant large bowel obstructions frequently require emergency surgery. Compliance with enhanced recovery after surgery programmes is significantly reduced due to non-removal of the nasogastric tube in the postoperative period. The first aim of the present study was to research factors associated with the failure of immediate nasogastric tube removal in patients who had undergone emergency surgery for malignant large bowel obstruction. The second aim was to assess the morbidity linked to nasogastric tube reinsertion.
Methods This retrospective and monocentric study included all consecutive patients admitted for acute malignant large bowel obstruction who underwent emergency surgery. Patients who were not primarily operated on were excluded (n = 178; 69.3%). The group of patients requiring nasogastric tube (NGT) reinsertion was compared with the group that did not require NGT reinsertion.
Results Seventy-nine patients underwent emergency surgery, of which 18 (22.8%) required nasogastric tube reinsertion. There was no difference between the two groups with regard to (a) immediate nasogastric tube removal (p = 0.87) and (b) inclusion in an enhanced recovery programme (p = 0.75). However, preoperative small bowel dilatation was associated with a reduction in the need for NGT reinsertion (p = 0.04). A left-sided tumour was also associated with the need for NGT reinsertion in uni- (p = 0.034) and multivariate analysis (OR = 8; p \ 0.05). Surgical access and procedure were not significantly associated with NGT reinsertion. The postoperative course influenced NGT reinsertion, which was significantly associated with postoperative ileus (OR = 4; p \ 0.05) and postoperative morbidity (OR = 4; p \ 0.05). Morbidity was not linked to nasogastric tube removal.
Conclusion Nasogastric tube reinsertion was not affected by immediate removal of the tube. Left-sided tumours and patients at risk of postoperative ileus should be managed with caution. Immediate nasogastric tube removal is not contraindicated in the case of large bowel obstruction because it is not associated with a higher risk of NGT reinsertion.
DA  - 2017/07//
PY  - 2017
DO  - 10.1007/s00268-017-3949-z
DP  - DOI.org (Crossref)
VL  - 41
IS  - 7
SP  - 1903
EP  - 1909
J2  - World J Surg
LA  - en
SN  - 0364-2313, 1432-2323
ST  - Primary Surgery for Malignant Large Bowel Obstruction
UR  - http://link.springer.com/10.1007/s00268-017-3949-z
Y2  - 2022/02/01/16:08:07
ER  - 

TY  - JOUR
TI  - Prolonged postoperative ileus following right‐ versus left‐sided colectomy: A systematic review and meta‐analysis
AU  - Seo, Sean Ho Beom
AU  - Carson, Daniel A.
AU  - Bhat, Sameer
AU  - Varghese, Chris
AU  - Wells, Cameron I.
AU  - Bissett, Ian P.
AU  - O'Grady, Greg
T2  - Colorectal Disease
AB  - Methods: The MEDLINE, Embase, Cochrane Library and CENTRAL databases were systematically searched for articles reporting GI recovery outcomes in adults undergoing elective right-­versus left-­sided colectomy (excluding with ileostomy) of any surgical approach. The primary outcome was PPOI, and secondary outcomes included time to first passage of flatus, stool and tolerance of solid diet, and postoperative complications. Subgroup analyses of laparoscopic procedures and cohorts without inflammatory bowel disease and sensitivity analysis of adjusted multivariate results were also performed.
Results: Nine studies were identified, of which seven were included in the meta-­analysis, comprising 29 068 colectomies (14 581 right-­sided; 14 487 left-­sided). PPOI was heterogeneously defined and was significantly more likely following right-s­ ided compared to left-­sided colectomy regardless of the surgical approach (OR 1.78, 95% CI 1.32–­2.39; P < 0.01; I2 = 51%), as well as on subgroup analyses and adjusted multivariate meta-­ analysis. Secondary outcomes were reported in only a few small studies; hence meta-­ analysis did not produce reliable results.
Conclusion: Based on heterogeneous definitions, consistently higher rates of PPOI were observed following right-­ versus left-­sided colectomy. These differences are currently unexplained and highlight the need for further research into the pathophysiology of ileus.
DA  - 2021/12//
PY  - 2021
DO  - 10.1111/codi.15969
DP  - DOI.org (Crossref)
VL  - 23
IS  - 12
SP  - 3113
EP  - 3122
J2  - Colorectal Disease
LA  - en
SN  - 1462-8910, 1463-1318
ST  - Prolonged postoperative ileus following right‐ versus left‐sided colectomy
UR  - https://onlinelibrary.wiley.com/doi/10.1111/codi.15969
Y2  - 2022/02/01/16:08:27
ER  - 

TY  - JOUR
TI  - Comparison of robot-assisted surgery, laparoscopic-assisted surgery, and open surgery for the treatment of colorectal cancer: A network meta-analysis
AU  - Sheng, Shihou
AU  - Zhao, Tiancheng
AU  - Wang, Xu
T2  - Medicine
AB  - Background: The aim of this study was to find the better treatment for colorectal cancer (CRC) by comparing robot-assisted colorectal surgery (RACS), laparoscopic-assisted colorectal surgery (LACS), and open surgery using network meta-analysis.
Methods: A literature search updated to August 15, 2017 was performed. All the included literatures were evaluated according to the quality evaluation criteria of bias risk recommended by the Cochrane Collaboration. All data were comprehensively analyzed by ADDIS. Odds ratio (OR), mean difference (MD), and 95% confidence interval (CI) were used to show the effect index of all data. The degree of convergence of the model was evaluated by the Brooks–Gelman–Rubin method with the potential scale reduction factor (PSRF) as the evaluation indicator.
Results: The PSRF values of operation time, estimated blood loss, length of hospital stay, complication, mortality, and anastomotic leakage ranged from 1.00 to 1.01, and those of wound infection, bleeding, and ileus ranged from 1.00 to 1.02. Open surgery had the shortest operation time compared with LACS and RACS. Furthermore, compared with LACS, the amount of blood loss, complication, mortality, bleeding rate, and ileus rate for RACS were the least, and the length of hospital stay for RACS was the shortest. The anastomotic leakage rate for LACS was the least, but there was no significant difference compared with those of RACS and open surgery. The wound infection rate for LACS was the least, but there was no significant difference compared with that of RACS.
Conclusion: RACS might be a better treatment for patients with CRC. Abbreviations: CI = confidence interval, CRC = colorectal cancer, LACS = laparoscopic-assisted colorectal surgery, MD = mean difference, OR = odds ratio, PSRF = potential scale reduction factor, RACS = robot-assisted colorectal surgery.
DA  - 2018/08//
PY  - 2018
DO  - 10.1097/MD.0000000000011817
DP  - DOI.org (Crossref)
VL  - 97
IS  - 34
SP  - e11817
LA  - en
SN  - 0025-7974
ST  - Comparison of robot-assisted surgery, laparoscopic-assisted surgery, and open surgery for the treatment of colorectal cancer
UR  - https://journals.lww.com/00005792-201808240-00023
Y2  - 2022/02/01/16:08:30
ER  - 

TY  - JOUR
TI  - Male sex, ostomy, infection, and intravenous fluids are associated with increased risk of postoperative ileus in elective colorectal surgery
AU  - Koch, Kelsey E.
AU  - Hahn, Amy
AU  - Hart, Alexander
AU  - Kahl, Amanda
AU  - Charlton, Mary
AU  - Kapadia, Muneera R.
AU  - Hrabe, Jennifer E.
AU  - Cromwell, John W.
AU  - Hassan, Imran
AU  - Gribovskaja-Rupp, Irena
T2  - Surgery
AB  - Background: Postoperative ileus is a common and costly complication after elective colorectal surgery. Effects of intravenous fluid administration remain controversial, and the effect of ostomy construction has not been fully evaluated. Various restrictive intravenous fluid protocols may adversely affect renal function. We aimed to investigate the impact of intestinal reconstruction and intravenous fluid on ileus and renal function after colorectal resection under an enhanced recovery protocol.
Methods: A retrospective study of a prospectively maintained institutional database for a tertiary academic medical center following National Surgical Quality Improvement Program standards was reviewed, analyzing elective colorectal resections performed under enhanced recovery protocol from 2015 to 2018. Postoperative ileus was defined as nasogastric decompression, nil per os >3 days postoperatively, or nasogastric tube insertion. Patients with and without ileus were compared. Intravenous fluid and different anastomoses and ostomies were investigated. Acute kidney injury was a secondary outcome, due to the potential of renal damage with restriction of intravenous fluid volume during and after surgery and controversy in current literature in this matter.
Results: Postoperative ileus occurred in 18.5% of patients (n ¼ 464). Male sex (odds ratio 1.97, 95% confidence interval 1.12e3.52) and postoperative infection (odds ratio 2.13, 95% confidence interval 1.03 e4.35) were associated with ileus. Compared to colorectal anastomosis, ileostomy/ileorectal anastomosis had the highest risk of ileus (odds ratio 4.9, 95% confidence interval 2.33e11.3), colostomy second highest (odds ratio 3.3, 95% confidence interval 1.35e8.39), while ileocolic anastomosis did not significantly differ (odds ratio 2.06, 95% confidence interval 0.69e5.85) on multivariate analysis. Each liter of intravenous fluid within the first 72 hours significantly correlated with postoperative ileus (odds ratio 1.41, 95% confidence interval 1.27e1.59). Rates of acute kidney injury did not differ (P ¼ .18).
Conclusion: Each additional liter of intravenous fluid given in the first 72 hours increased the risk of postoperative ileus 1.4-fold. There is substantially higher risk of ileus with male sex, infection, ileostomy/ ileorectal anastomosis, and colostomy. Judicious use of intravenous fluid, as described in our enhanced recovery protocol, is not detrimental for renal function in the setting of normal baseline.
DA  - 2021/11//
PY  - 2021
DO  - 10.1016/j.surg.2021.05.035
DP  - DOI.org (Crossref)
VL  - 170
IS  - 5
SP  - 1325
EP  - 1330
J2  - Surgery
LA  - en
SN  - 00396060
UR  - https://linkinghub.elsevier.com/retrieve/pii/S0039606021004955
Y2  - 2022/02/01/16:08:36
ER  - 

TY  - JOUR
TI  - Risk Factors for Prolonged Postoperative Ileus in Colorectal Surgery: A Systematic Review and Meta-analysis
AU  - Quiroga-Centeno, Andrea Carolina
AU  - Jerez-Torra, Kihara Alejandra
AU  - Martin-Mojica, Pedro Antonio
AU  - Castañeda-Alfonso, Sergio Andrés
AU  - Castillo-Sánchez, María Emma
AU  - Calvo-Corredor, Oscar Fernando
AU  - Gómez-Ochoa, Sergio Alejandro
T2  - World Journal of Surgery
AB  - Background Prolonged postoperative ileus (PPOI) represents a frequent complication following colorectal surgery, affecting approximately 10–15% of these patients. The objective of this study was to evaluate the perioperative risk factors for PPOI development in colorectal surgery.
Methods The present systematic review and meta-analysis was conducted in accordance with the PRISMA Statement. PubMed, EMBASE, SciELO, and LILACS databases were searched, without language or time restrictions, from inception until December 2018. The keywords used were: Ileus, colon, colorectal, sigmoid, rectal, postoperative, postoperatory, surgery, risk, factors. The Newcastle–Ottawa scale and the Jadad scale were used for bias assessment, while the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) approach was used for quality assessment of evidence on outcome levels.
Results Of the 64 studies included, 42 were evaluated in the meta-analysis, comprising 29,736 patients (51.84% males; mean age 62 years), of whom 2844 (9.56%) developed PPOI. Significant risk factors for PPOI development were: male sex (OR 1.43; 95% CI 1.25–1.63), age (MD 3.17; 95% CI 1.63–4.71), cardiac comorbidities (OR 1.54; 95% CI 1.19–2.00), previous abdominal surgery (OR 1.44; 95% CI 1.19, 1.75), laparotomy (OR 2.47; 95% CI 1.77–3.44), and ostomy creation (OR 1.44; 95% CI 1.04–1.98). Included studies evidenced a moderate heterogeneity. The quality of evidence was regarded as very low-moderate according to the GRADE approach.
Conclusions Multiple factors, including demographic characteristics, past medical history, and surgical approach, may increase the risk of developing PPOI in colorectal surgery patients. The awareness of these will allow a more accurate assessment of PPOI risk in order to take measures to decrease its impact on this population.
DA  - 2020/05//
PY  - 2020
DO  - 10.1007/s00268-019-05366-4
DP  - DOI.org (Crossref)
VL  - 44
IS  - 5
SP  - 1612
EP  - 1626
J2  - World J Surg
LA  - en
SN  - 0364-2313, 1432-2323
ST  - Risk Factors for Prolonged Postoperative Ileus in Colorectal Surgery
UR  - http://link.springer.com/10.1007/s00268-019-05366-4
Y2  - 2022/02/01/16:08:39
ER  - 

TY  - JOUR
TI  - Colorectal cancer
AU  - Kuipers, Ernst J.
AU  - Grady, William M.
AU  - Lieberman, David
AU  - Seufferlein, Thomas
AU  - Sung, Joseph J.
AU  - Boelens, Petra G.
AU  - van de Velde, Cornelis J. H.
AU  - Watanabe, Toshiaki
T2  - Nature Reviews Disease Primers
AB  - Colorectal cancer had a low incidence several decades ago. However, it has become a predominant cancer and now accounts for approximately 10% of cancer-related mortality in western countries. The ‘rise’ of colorectal cancer in developed countries can be attributed to the increasingly ageing population, unfavourable modern dietary habits and an increase in risk factors such as smoking, low physical exercise and obesity. New treatments for primary and metastatic colorectal cancer have emerged, providing additional options for patients; these treatments include laparoscopic surgery for primary disease, more-aggressive resection of metastatic disease (such as liver and pulmonary metastases), radiotherapy for rectal cancer and neoadjuvant and palliative chemotherapies. However, these new treatment options have had limited impact on cure rates and long-term survival. For these reasons, and the recognition that colorectal cancer is long preceded by a polypoid precursor, screening programmes have gained momentum. This Primer provides an overview of the current state of art knowledge on the epidemiology and mechanisms of colorectal cancer, as well as on diagnosis and treatment.
DA  - 2015/12/17/
PY  - 2015
DO  - 10.1038/nrdp.2015.65
DP  - DOI.org (Crossref)
VL  - 1
IS  - 1
SP  - 15065
J2  - Nat Rev Dis Primers
LA  - en
SN  - 2056-676X
UR  - http://www.nature.com/articles/nrdp201565
Y2  - 2022/02/01/16:08:41
ER  - 

TY  - JOUR
TI  - Targets for Intervention? Preoperative Predictors of Postoperative Ileus After Colorectal Surgery in an Enhanced Recovery Protocol
AU  - Teng, Cindy Y.
AU  - Myers, Sara
AU  - Kenkre, Tanya S.
AU  - Doney, Luke
AU  - Tsang, Wai Lok
AU  - Subramaniam, Kathirvel
AU  - Esper, Stephen A.
AU  - Holder-Murray, Jennifer
T2  - Journal of Gastrointestinal Surgery
AB  - Background Postoperative ileus occurs in up to 30% of colorectal surgery patients and is associated with increased length of stay, costs, and morbidity. While Enhanced Recovery Protocols seek to accelerate postoperative recovery, data on modifiable preoperative factors associated with postoperative ileus in this setting are limited. We aimed to identify preoperative predictors of postoperative ileus following colorectal surgery in Enhanced Recovery Protocols, to determine new intervention targets.
DA  - 2021/08//
PY  - 2021
DO  - 10.1007/s11605-020-04876-0
DP  - DOI.org (Crossref)
VL  - 25
IS  - 8
SP  - 2065
EP  - 2075
J2  - J Gastrointest Surg
LA  - en
SN  - 1091-255X, 1873-4626
ST  - Targets for Intervention?
UR  - https://link.springer.com/10.1007/s11605-020-04876-0
Y2  - 2022/06/08/
ER  - 

TY  - JOUR
TI  - Incidence and predictors of prolonged postoperative ileus after colorectal surgery in the context of an enhanced recovery pathway
AU  - Alhashemi, Mohsen
AU  - Fiore, Julio F.
AU  - Safa, Nadia
AU  - Al Mahroos, Mohammed
AU  - Mata, Juan
AU  - Pecorelli, Nicolò
AU  - Baldini, Gabriele
AU  - Dendukuri, Nandini
AU  - Stein, Barry L.
AU  - Liberman, A. Sender
AU  - Charlebois, Patrick
AU  - Carli, Franco
AU  - Feldman, Liane S.
T2  - Surgical Endoscopy
AB  - Background  Prolonged postoperative ileus (PPOI) is common after colorectal surgery but has not been widely studied in the context of enhanced recovery pathways (ERPs) that include interventions aimed to accelerate gastrointestinal recovery. The aim of this study is to estimate the incidence and predictors of PPOI in the context of an ERP for colorectal surgery.
Methods  We analyzed data from an institutional colorectal surgery ERP registry. Incidence of PPOI was estimated according to a definition adapted from Vather (intolerance of solid food and absence of flatus or bowel movement for ≥ 4 days) and compared to other definitions in the literature. Potential risk factors for PPOI were identified from previous studies, and their predictive ability was evaluated using Bayesian model averaging (BMA). Results are presented as posterior effect probability (PEP). Evidence of association was categorized as: no evidence (PEP < 50%), weak evidence (50–75%), positive evidence (75–95%), strong evidence (95–99%), and very strong evidence (> 99%).
Results  There were 323 patients analyzed (mean age 63.5 years, 51% males, 74% laparoscopic, 33% rectal resection). The incidence of PPOI was 19% according to the primary definition, but varied between 11 and 59% when using other definitions. On BMA analysis, intraoperative blood loss (PEP 99%; very strong evidence), administration of any intravenous opioids in the first 48 h (PEP 94%; strong evidence), postoperative epidural analgesia (PEP 56%; weak evidence), and non-compliance with intra-operative fluid management protocols (3 ml/kg/h for laparoscopic and 5 ml/kg/h for open; PEP 55%, weak evidence) were predictors of PPOI.
Conclusions  The incidence of PPOI after colorectal surgery is high even within an established ERP and varied considerably by diagnostic criteria, highlighting the need for a consensus definition. The use of intravenous opioids is a modifiable strong predictor of PPOI within an ERP, while the role of epidural analgesia and intraoperative fluid management should be further evaluated.
DA  - 2019/07//
PY  - 2019
DO  - 10.1007/s00464-018-6514-4
DP  - DOI.org (Crossref)
VL  - 33
IS  - 7
SP  - 2313
EP  - 2322
J2  - Surg Endosc
LA  - en
SN  - 0930-2794, 1432-2218
UR  - http://link.springer.com/10.1007/s00464-018-6514-4
Y2  - 2022/06/08/01:55:56
ER  - 

TY  - JOUR
TI  - Does enhanced recovery reduce postoperative ileus after colorectal surgery?
AU  - Barbieux, J.
AU  - Hamy, A.
AU  - Talbot, M.F.
AU  - Casa, C.
AU  - Mucci, S.
AU  - Lermite, E.
AU  - Venara, A.
T2  - Journal of Visceral Surgery
AB  - Introduction: While enhanced recovery after surgery (ERAS) has been proven to improve results in colorectal operations with regard to morbidity and duration of hospital stay, its impact on recovery of bowel motility is poorly documented. The aims of this study were to assess the impact of ERAS on bowel motility recovery, and to assess the consequences of the definition of postoperative ileus on its reported incidence in the literature. Material and methods: This is a single-center prospective observational study of consecutive patients who underwent colorectal resection with anastomosis over a period of 17 months. Global resumption of intestinal transit (GROT) was defined as passage of stool combined with alimentary tolerance of solid food.
Results: One hundred and thirty-one patients were included. A median of 14 items (range: 13—16) was complied out of 19 observable items in the protocol. Median time to passage of flatus (MTPF) was 2 days and the GROT was 3 days. The time interval to MTPF as well as to GROT decreased as adherence to the ERAS protocol increased (respectively P < 0.001, r2 = 0.11 and P = 0.04, r2 = 0.06). The incidence of postoperative ‘‘ileus’’ varied from 1.5% to 61.8% depending on the interval chosen to define ileus (cut-off from 1 to 7 days). Adherence to ≥ 85% of the items in the ERAS protocol protected patients from ‘‘prolonged ileus’’, i.e., lasting ≥ 4 days (OR = 0.35; 95% CI = 0.15 to 0.83).
Conclusion: The implementation of and compliance with an ERAS protocol allowed a reduction in the time to GROT. There is a need for a consensual definition of postoperative ileus. © 2016 Elsevier Masson SAS. All rights reserved.
DA  - 2017/04//
PY  - 2017
DO  - 10.1016/j.jviscsurg.2016.08.003
DP  - DOI.org (Crossref)
VL  - 154
IS  - 2
SP  - 79
EP  - 85
J2  - Journal of Visceral Surgery
LA  - en
SN  - 18787886
UR  - https://linkinghub.elsevier.com/retrieve/pii/S1878788616301199
Y2  - 2022/06/08/02:05:54
ER  - 

TY  - JOUR
TI  - Clinical indicators for the incidence of postoperative ileus after elective surgery for colorectal cancer
AU  - Namba, Yosuke
AU  - Hirata, Yuzo
AU  - Mukai, Shoichiro
AU  - Okimoto, Sho
AU  - Fujisaki, Seiji
AU  - Takahashi, Mamoru
AU  - Fukuda, Toshikatsu
AU  - Ohdan, Hideki
T2  - BMC Surgery
AB  - Background:  The occurrence of postoperative ileus leads to increased patient morbidity, longer hospitalization, and higher healthcare costs. No clear policy on postoperative ileus prevention exists. Therefore, we aim to evaluate the clinical factors involved in the development of postoperative ileus after elective surgery for colorectal cancer.
Methods:  We retrospectively analyzed patients who underwent elective surgery involving bowel resection with or without re-anastomosis for colon cancer between April 2015 and March 2020. The primary readout was the presence or absence of postoperative ileus. Univariate and multivariate analyses were used to identify pre- and intraoperative risk factors, and the incidence of postoperative ileus was assessed using independent factors.
Results:  Postoperative ileus occurred in 48 out of 356 patients (13.5%). In multivariate analysis, male sex poor performance status, and intraoperative in–out balance per body weight were independently associated with postoperative ileus development. The incidence of postoperative ileus was 2.5% in the cases with no independent factors; however, it increased to 36.1% when two factors were observed and 75.0% when three factors were matched.
Conclusions:  We discovered that male gender, poor performance status, and intraoperative in–out balance per body weight were associated with the development of postoperative ileus. Of these, intraoperative in–out balance per body weight is a controllable factor. Hence it is important to control the intraoperative in–out balance to lower the risk for postoperative ileus.
DA  - 2021/12//
PY  - 2021
DO  - 10.1186/s12893-021-01093-7
DP  - DOI.org (Crossref)
VL  - 21
IS  - 1
SP  - 80
J2  - BMC Surg
LA  - en
SN  - 1471-2482
UR  - https://bmcsurg.biomedcentral.com/articles/10.1186/s12893-021-01093-7
Y2  - 2022/06/08/02:08:21
ER  - 

TY  - JOUR
TI  - Asociación entre desenlaces clínicos y cumplimiento del protocolo de recuperación mejorada después de la cirugía (ERAS) en procedimientos colorrectales: estudio multicéntrico
AU  - Mendivelso Duarte, Fredy
AU  - Barrios Parra, Arnold José
AU  - Zárate-López, Eduardo
AU  - Navas-Camacho, Ángela María
AU  - Álvarez, Adrián Osvaldo
AU  - Mc Loughlin, Santiago
AU  - Gabriela Renee Mendoza, Gabriela Renee
AU  - Enciso-Pérez6, Daniel
AU  - Rodríguez-Barajas, Rubén
AU  - Jiménez-Chávez, María Sofía
AU  - Ramírez, José
AU  - Faber, Florencia
AU  - Solla, Gonzalo
AU  - Viola-Malet, Marcelo
AU  - Rodríguez-Bedoya, Milena
T2  - Revista Colombiana de Cirugía
AB  - Introduction. Enhanced Recovery After Surgery (ERAS) protocol has been designed as an innovation in health after demonstrating that the improvement in medical devices and the refinement of techniques reached the plateau in reducing complications. With these strategies of perioperative medicine, in colorectal surgery morbidity and hospital stay are reduced. The aim of the study was to evaluate whether the rate of adherence to the ERAS protocol is associated with surgical outcomes.
DA  - 2020/10/16/
PY  - 2020
DO  - 10.30944/20117582.662
DP  - DOI.org (Crossref)
VL  - 35
IS  - 4
SP  - 601
EP  - 613
J2  - Rev Colomb Cir
LA  - es
SN  - 2619-6107, 2011-7582
ST  - Asociación entre desenlaces clínicos y cumplimiento del protocolo de recuperación mejorada después de la cirugía (ERAS) en procedimientos colorrectales
UR  - https://www.revistacirugia.org/index.php/cirugia/article/view/662
Y2  - 2022/06/08/02:12:11
ER  - 

TY  - JOUR
TI  - Cirugía para enfermedad colo-rectal vía laparoscópica por el servicio de coloproctología del Hospital Militar Central (2005 – 2015)
AU  - Sánchez Gallego, Luis Alfonso
AU  - Obando Rodallega, Alexander
AU  - Barbosa, Ronel
AU  - Medellín Abueta, Anwar Yair
AU  - Martínez Jaramillo, Carlos Edmundo
AU  - Senejoa Nuñez, Nairo Javier
AU  - Mateus Barbosa, Lina María
AU  - Ibañez Varela, Heinz Orlando
T2  - Revista Colombiana de Gastroenterología
AB  - Introduction: Various surgical approaches have been established to treat colorectal disease, but in the last 30 years the evidence has shown that laparoscopic techniques produce greater benefits than do laparotomies. This depends directly on continuous training and the practical criteria of colorectal surgeons. Objective: This study clinically and surgically characterized patients undergoing colorectal laparoscopic surgery by the Coloproctology Service of the Hospital Militar Central in Bogotá between 2005 and 2015. Methodology: This is a retrospective, cross-sectional study. Results: Patients’ demographic characteristics (clinical and pre-surgery), diseases, times, conversion rates, complications and recovery profiles during the study period were recorded by the Coloproctology service and were similar to those reported elsewhere in the world. Conclusions: Although we only collected information related to the last ten years of surgery, this data puts us at the level of centers of excellence in the management of colorectal disease worldwide.
DA  - 2018/04/11/
PY  - 2018
DO  - 10.22516/25007440.228
DP  - DOI.org (Crossref)
VL  - 33
IS  - 1
SP  - 8
J2  - Rev. Colomb. Gastroenterol.
LA  - es
SN  - 2500-7440, 0120-9957
UR  - https://www.revistagastrocol.com/index.php/rcg/article/view/228
Y2  - 2022/06/08/02:14:59
ER  - 

TY  - JOUR
TI  - Determinación de los factores predictivos para complicaciones en cirugía electiva de pacientes con cáncer colorrectal. Experiencia del Instituto de Cancerología Las Américas Auna (Colombia, 2016-2019)
AU  - Molina Meneses, Sandra Patricia
AU  - Palacios Fuenmayor, Luis Jose
AU  - Castaño LLano, Rodrigo de Jesus
AU  - Mejia Gallego, Jorge Ivan
AU  - Sánchez Patiño, Lucy Astrid
T2  - Revista Colombiana de Cirugía
AB  - Introduction. The fundamental pillar of colorectal cancer treatment is surgery, a situation that exposes patients to the possible presentation of complications, morbidity and mortality, poor quality of life, tumor recurrence or death. The objective of this study was to determine the clinical and surgical variables that affect the risk of the appearance of complications in colorectal cancer patients taken to elective surgery between 2016 and 2019.
DA  - 2021/07/22/
PY  - 2021
DO  - 10.30944/20117582.863
DP  - DOI.org (Crossref)
VL  - 36
IS  - 4
SP  - 637
EP  - 646
J2  - Rev Colomb Cir
LA  - es
SN  - 2619-6107, 2011-7582
UR  - https://www.revistacirugia.org/index.php/cirugia/article/view/863
Y2  - 2022/06/08/02:17:01
ER  - 

TY  - JOUR
TI  - Smoking is a risk factor for postoperative ileus after radical resection in male patients
AU  - Wang, Jiangling
AU  - Guo, Wenjing
AU  - Cui, Xiaoying
AU  - Shen, Yajian
AU  - Guo, Ye
AU  - Cai, Yunfang
AU  - Liu, Xinyi
AU  - Fang, Man
AU  - Gu, Bin
AU  - Yuan, Junbo
AU  - Xie, Yuyizi
AU  - Xie, Kangjie
AU  - Zhou, Huidan
AU  - Chen, Xinzhong
T2  - Medicine
AB  - Most smokers are males, and smoking has been indicated as a risk factor for many cancers as well as postoperative complications after cancer surgery. However, little is known about whether smoking is a risk factor for postoperative ileus (POI) after radical rectal cancer resection in males. The aim of this study was to assess whether smoking is a risk factor for POI after radical resection in male rectal cancer patients.
DA  - 2021/10/22/
PY  - 2021
DO  - 10.1097/MD.0000000000027465
DP  - DOI.org (Crossref)
VL  - 100
IS  - 42
SP  - e27465
LA  - en
SN  - 0025-7974, 1536-5964
UR  - https://journals.lww.com/10.1097/MD.0000000000027465
Y2  - 2022/06/08/02:36:52
ER  - 

TY  - JOUR
TI  - Risk factors for postoperative ileus after colorectal cancer surgery
AU  - Rybakov, E. G.
AU  - Shelygin, Y. A.
AU  - Khomyakov, E. A.
AU  - Zarodniuk, I. V.
T2  - Colorectal Disease
AB  - Aim The aim was to assess the rate and independent risk factors of postoperative ileus after colorectal cancer surgery.
DA  - 2018/03//
PY  - 2018
DO  - 10.1111/codi.13888
DP  - DOI.org (Crossref)
VL  - 20
IS  - 3
SP  - 189
EP  - 194
J2  - Colorectal Dis
LA  - en
SN  - 14628910
UR  - https://onlinelibrary.wiley.com/doi/10.1111/codi.13888
Y2  - 2022/06/08/02:38:51
ER  - 

TY  - JOUR
TI  - Visceral obesity is a preoperative risk factor for postoperative ileus after surgery for colorectal cancer: Single‐institution retrospective analysis
AU  - Morimoto, Yoshihiro
AU  - Takahashi, Hidekazu
AU  - Fujii, Makoto
AU  - Miyoshi, Norikatsu
AU  - Uemura, Mamoru
AU  - Matsuda, Chu
AU  - Yamamoto, Hirofumi
AU  - Mizushima, Tsunekazu
AU  - Mori, Masaki
AU  - Doki, Yuichiro
T2  - Annals of Gastroenterological Surgery
AB  - Methods: This study included 417 consecutive patients with colorectal cancer who underwent elective surgery at our institute from January 2010 to December 2012. Visceral fat area (VFA) was calculated by image analysis software. VO was defined as VFA ≥100 cm2. We assessed 49 factors, including VO, comorbidities, surgical procedure, and postoperative complications. Data were analyzed using a propensity scorematching strategy.
Results: Postoperative ileus occurred in 18 patients (4.3%) from the entire cohort, and in 14 (5.5%) of the 256 matched patients. Multivariate analysis (n = 417 patients) showed that significant risk factors for POI included VO (OR 7.9, 95% confidence interval [CI] 1.9‐32.1, P = .004), open surgery (OR 6.4, 95% CI 1.6‐26.7, P = .010), and pelvic/intra‐abdominal abscess (OR 11.0, 95% CI 1.1‐110.2, P = .041). Propensity score matching showed two independent risk factors in the multivariate analysis: VO (OR 6.2, 95% CI 1.3‐30.4, P = .025) and open surgery (OR 9.1, 95% CI 2.0‐40.5, P = .004).
Conclusion: Visceral obesity may be an independent risk factor for POI in patients with colorectal cancer.
DA  - 2019/11//
PY  - 2019
DO  - 10.1002/ags3.12291
DP  - DOI.org (Crossref)
VL  - 3
IS  - 6
SP  - 657
EP  - 666
J2  - Ann Gastroenterol Surg
LA  - en
SN  - 2475-0328, 2475-0328
ST  - Visceral obesity is a preoperative risk factor for postoperative ileus after surgery for colorectal cancer
UR  - https://onlinelibrary.wiley.com/doi/10.1002/ags3.12291
Y2  - 2022/06/08/02:41:48
ER  - 

TY  - JOUR
TI  - The incidence of postoperative ileus in patients who underwent robotic assisted radical prostatectomy
AU  - Ahmet Tunc
T2  - Central European Journal of Urology
AB  - Introduction Our aim was to examine the incidence and risk factors of postoperative ileus among patients who underwent robot–assisted radical prostatectomy (RARP). Material and methods We retrospectively reviewed 239 patients who underwent RARP transperitoneally between February 2009 and December 2011. Patients switched to open surgery were excluded. We defined postoperative ileus as intolerance of a solid diet continued until the third postoperative day and beyond. By Clavien classification, we evaluated the perioperative complications that cause or contribute to postoperative ileus. Similarly, we analyzed the impact of anesthesia risk score on the incidence of postoperative ileus.
Results The study included 228 patients. The mean period to tolerate solid food was 1.24 days. Only 6 patients experienced postoperative ileus, all of whom were treated with a conservative approach. The two groups differed significantly in the duration of abdominal drainage, hospital stay, modified Clavien classification, and the presence of comorbidity diabetes mellitus (P <0.5 for all factors). Multiple logistic regression analysis revealed that diabetes mellitus was an independent risk factor for postoperative ileus.
Conclusions We suggest that diabetes mellitus is an independent risk factor for postoperative ileus in patients undergoing robot–assisted radical prostatectomy.
DA  - 2014///
PY  - 2014
DO  - 10.5173/ceju.2014.01.art4
DP  - DOI.org (Crossref)
VL  - 67
IS  - 01
J2  - CEJU
LA  - en
SN  - 20804873
UR  - http://ceju.online/journal/2014/morbidity-postoperative-ileus-prostate-cancer-robot-assisted-radical-prostatectomy-309.php
Y2  - 2022/06/08/02:49:22
ER  - 

TY  - JOUR
TI  - Postoperative ileus—An ongoing conundrum
AU  - Wattchow, David
AU  - Heitmann, Paul
AU  - Smolilo, David
AU  - Spencer, Nick J.
AU  - Parker, Dominic
AU  - Hibberd, Timothy
AU  - Brookes, Simon S. J.
AU  - Dinning, Phil G.
AU  - Costa, Marcello
T2  - Neurogastroenterology & Motility
AB  - Background: Postoperative ileus is common and is a major clinical problem. It has been widely studied in patients and in experimental models in laboratory animals. A wide variety of treatments have been tested to prevent or modify the course of this disorder.
DA  - 2021/05//
PY  - 2021
DO  - 10.1111/nmo.14046
DP  - DOI.org (Crossref)
VL  - 33
IS  - 5
J2  - Neurogastroenterology & Motility
LA  - en
SN  - 1350-1925, 1365-2982
UR  - https://onlinelibrary.wiley.com/doi/10.1111/nmo.14046
Y2  - 2022/06/08/03:09:26
ER  - 

TY  - JOUR
TI  - The impact of intravenous acetaminophen on pain after abdominal surgery: a meta-analysis
AU  - Blank, Jacqueline J.
AU  - Berger, Nicholas G.
AU  - Dux, Justin P.
AU  - Ali, Fadwa
AU  - Ludwig, Kirk A.
AU  - Peterson, Carrie Y.
T2  - Journal of Surgical Research
AB  - Background: Pain after surgery is commonly controlled with opioid pain medications. A multi-modal pain strategy that involves acetaminophen may help minimize the negative consequences of opioids, such as ileus, respiratory depression, and addictive potential. There are limited data on the effectiveness of intravenous (IV) acetaminophen in comparison with other nonopioid pain medications. Materials and methods: Four databases were queried for the keywords “acetaminophen,” “intravenous,” and “postoperative”. Prospective studies of adult patients receiving at least 24 h of IV acetaminophen after intraabdominal surgery were analyzed for 12- and 24-h pain scores and 24-h narcotic consumption. A random effects model was performed using mean differences and 95% confidence intervals to assess the effect of IV acetaminophen on outcomes. Heterogeneity was assessed using c2 and the I2 statistics.
Results: Seventeen articles were identified that complied with inclusion and exclusion criteria. There was no significant difference in 24-h pain scores between IV acetaminophen and any other comparator, or in secondary endpoints of 12-h pain scores and 24-h narcotic consumption. Subgroup analysis demonstrated significant benefit for IV acetaminophen in open surgeries for decreased 24-h narcotic consumption. When analyzing individual medications, non-steroidal anti-inflammatory drugs demonstrated the largest reduction in 24-h narcotic consumption. Data were of moderate quality and demonstrated significant heterogeneity between studies.
Conclusions: The lack of significant differences in primary endpoints may be explained by the heterogeneous, moderate-quality data. However, subgroup analyses suggested IV acetaminophen may be advantageous in open surgeries, and non-steroidal anti-inflammatory drugs may lower the 24-h narcotic requirement.
DA  - 2018/07//
PY  - 2018
DO  - 10.1016/j.jss.2018.02.032
DP  - DOI.org (Crossref)
VL  - 227
SP  - 234
EP  - 245
J2  - Journal of Surgical Research
LA  - en
SN  - 00224804
ST  - The impact of intravenous acetaminophen on pain after abdominal surgery
UR  - https://linkinghub.elsevier.com/retrieve/pii/S0022480418301185
Y2  - 2022/06/08/03:13:11
ER  - 

TY  - JOUR
TI  - Paralytic ileus in the United States: A cross-sectional study from the national inpatient sample
AU  - Solanki, Shantanu
AU  - Chakinala, Raja Chandra
AU  - Haq, Khwaja Fahad
AU  - Singh, Jagmeet
AU  - Khan, Muhammad Ali
AU  - Solanki, Dhanshree
AU  - Vyas, Manasee J
AU  - Kichloo, Asim
AU  - Mansuri, Uvesh
AU  - Shah, Harshil
AU  - Patel, Achint
AU  - Haq, Khwaja Saad
AU  - Iqbal, Umair
AU  - Nabors, Christopher
AU  - Khan, Hafiz Muzaffar Akbar
AU  - Aronow, Wilbert S
T2  - SAGE Open Medicine
AB  - Introduction: Paralytic ileus is a common clinical condition leading to significant morbidity and mortality. Most studies to date have focused on postoperative ileus, a common but not exclusive cause of the condition. There are limited epidemiological data regarding the incidence and impact of paralytic ileus and its relationship to other clinical conditions. In this cross-sectional study, we analyzed national inpatient hospitalization trends, demographic variation, cost of care, length of stay, and mortality for paralytic ileus hospitalizations as a whole.
Methods: The National Inpatient Sample database was used to identify all hospitalizations with the diagnosis of paralytic ileus (International Classification of Diseases, 9th Revision code 560.1) as primary or secondary diagnosis during the period from 2001 to 2011. Statistical analysis was performed using Cochran–Armitage trend test, Wilcoxon rank sum test, and Poisson regression.
Results: In 2001, there were 362,561 hospitalizations with the diagnosis of paralytic ileus as compared to 470,110 in 2011 (p < 0.0001). The age group 65–79 years was most commonly affected by paralytic ileus throughout the study period. Inhospital all-cause mortality decreased from 6.03% in 2001 to 5.10% in 2011 (p < 0.0001). However, the average cost of care per hospitalization increased from US$19,739 in 2001 to US$26,198 in 2011 (adjusted for inflation, p < 0.0001).
Conclusion: There was a significant rise in the number of hospitalizations of paralytic ileus with increased cost of care and reduced all-cause mortality.
DA  - 2020/01//
PY  - 2020
DO  - 10.1177/2050312120962636
DP  - DOI.org (Crossref)
VL  - 8
SP  - 205031212096263
J2  - SAGE Open Medicine
LA  - en
SN  - 2050-3121, 2050-3121
ST  - Paralytic ileus in the United States
UR  - http://journals.sagepub.com/doi/10.1177/2050312120962636
Y2  - 2022/06/08/03:20:13
ER  - 

TY  - JOUR
TI  - Postoperative ileus: mechanisms and future directions for research
AU  - Vather, Ryash
AU  - O'Grady, Greg
AU  - Bissett, Ian P
AU  - Dinning, Phil G
T2  - Clinical and Experimental Pharmacology and Physiology
AB  - Postoperative ileus (POI) is an abnormal pattern of gastrointestinal motility characterized by nausea, vomiting, abdominal distension and/or delayed passage of flatus or stool, which may occur following surgery. Postoperative ileus slows recovery, increases the risk of developing postoperative complications and confers a significant financial load on healthcare institutions. The aim of the present review is to provide a succinct overview of the clinical features and pathophysiological mechanisms of POI, with final comment on selected directions for future research.Terminology used when describing POI is inconsistent, with little differentiation made between the obligatory period of gut dysfunction seen after surgery (‘normal POI’) and the more clinically and pathologically significant entity of a ‘prolonged POI’. Both normal and prolonged POI represent a fundamentally similar pathophysiological phenomenon. The aetiology of POI is postulated to be multifactorial, with principal mediators being inflammatory cell activation, autonomic dysfunction (both primarily and as part of the surgical stress response), agonism at gut opioid receptors, modulation of gastrointestinal hormone activity and electrolyte derangements. A final common pathway for these effectors is impaired contractility and motility and gut wall oedema. There are many potential directions for future research. In particular, there remains scope to accurately characterize the gastrointestinal dysfunction that underscores an ileus, development of an accurate risk stratification tool will facilitate early implementation of preventive measures and clinical appraisal of novel therapeutic strategies that target individual pathways in the pathogenesis of ileus warrant further investigation.
DA  - 2014/05//
PY  - 2014
DO  - 10.1111/1440-1681.12220
DP  - DOI.org (Crossref)
VL  - 41
IS  - 5
SP  - 358
EP  - 370
J2  - Clin Exp Pharmacol Physiol
LA  - en
SN  - 03051870
ST  - Postoperative ileus
UR  - https://onlinelibrary.wiley.com/doi/10.1111/1440-1681.12220
Y2  - 2022/07/15/21:42:48
ER  - 

TY  - JOUR
TI  - Epidemiology, Pathophysiology and Medical Management of Postoperative Ileus in the Elderly:
AU  - Hiranyakas, Art
AU  - Bashankaev, Badma
AU  - Seo, Christina J.
AU  - Khaikin, Marat
AU  - Wexner, Steven D.
T2  - Drugs & Aging
DA  - 2011/02//
PY  - 2011
DO  - 10.2165/11586170-000000000-00000
DP  - DOI.org (Crossref)
VL  - 28
IS  - 2
SP  - 107
EP  - 118
J2  - Drugs & Aging
LA  - en
SN  - 1170-229X
ST  - Epidemiology, Pathophysiology and Medical Management of Postoperative Ileus in the Elderly
UR  - http://link.springer.com/10.2165/11586170-000000000-00000
Y2  - 2022/07/18/06:18:50
ER  - 

TY  - JOUR
TI  - Risk factors for the development of prolonged post-operative ileus following elective colorectal surgery
AU  - Vather, Ryash
AU  - Bissett, Ian P.
T2  - International Journal of Colorectal Disease
AB  - Purpose Prolonged post-operative ileus (PPOI) increases post-operative morbidity and prolongs hospital stay. An improved understanding of the elements which contribute to the genesis of PPOI is needed in the first instance to facilitate accurate risk stratification and institute effective preventive measures. The aim of this retrospective cohort study was to therefore determine the perioperative risk factors associated with development of PPOI.
DA  - 2013/10//
PY  - 2013
DO  - 10.1007/s00384-013-1704-y
DP  - DOI.org (Crossref)
VL  - 28
IS  - 10
SP  - 1385
EP  - 1391
J2  - Int J Colorectal Dis
LA  - en
SN  - 0179-1958, 1432-1262
UR  - http://link.springer.com/10.1007/s00384-013-1704-y
Y2  - 2022/07/18/06:19:16
ER  - 

TY  - JOUR
TI  - Postoperative ileus in an enhanced recovery pathway—a retrospective cohort study
AU  - Grass, Fabian
AU  - Slieker, Juliette
AU  - Jurt, Jonas
AU  - Kummer, Anne
AU  - Solà, Josep
AU  - Hahnloser, Dieter
AU  - Demartines, Nicolas
AU  - Hübner, Martin
T2  - International Journal of Colorectal Disease
AB  - Purpose Enhanced recovery after surgery (ERAS) protocols advocate no nasogastric tubes after colorectal surgery, but postoperative ileus (POI) remains a challenging clinical reality. The aim of this study was to assess incidence and risk factors of POI.
DA  - 2017/05//
PY  - 2017
DO  - 10.1007/s00384-017-2789-5
DP  - DOI.org (Crossref)
VL  - 32
IS  - 5
SP  - 675
EP  - 681
J2  - Int J Colorectal Dis
LA  - en
SN  - 0179-1958, 1432-1262
UR  - http://link.springer.com/10.1007/s00384-017-2789-5
Y2  - 2022/07/18/09:28:36
ER  -