TY - GEN AB - Previous studies have shown that self-efficacy and job satisfaction become critical factors that motivate educators to become productive in their career, and promote organizational excellence in education. However, changes in education policies resulting the teachers to have high workload in the workplace. This is a correlational research, and carried out to identify the relationship between workload and self-efficacy and job satisfaction among lecturers at vocational colleges. A total of 373 questionnaires containing 60 items were collected from the lecturers from 15 vocational colleges which were selected using cluster random sampling technique. Data was analyzed using SPSS version 22. Data were analyzed using t-test, ANOVA and Pearson-r correlation. Results showed that the workload of the lecturers at vocational colleges are at a high level (mean = 3.73), self-efficacy remained at a high level (mean = 3.81) and job satisfaction lecturer at the medium level (mean = 3.57). Based on the analysis, it was found that the workload significantly correlated with self-efficacy and job satisfaction in a negative direction and the strength of the relationship is at the low level. Self-efficacy was found to have a significant relationship with job satisfaction and the strength of the relationship is at the medium level. Keywords: Work load; self efficacy; job satisfaction; technical and vocational education AU - florez castilla, laura melisa DO - 10.1051/matecconf/201712107005 IS - 2 KW - () KW - 21 century KW - 21 st Century Learning KW - 21 st Century Skills KW - Academic Level KW - Blended Learning KW - Digital learning module KW - Industri pembuatan KW - Motivacion para el aprendizaje KW - Teacher Readiness KW - Understanding KW - User Acceptance KW - ZDP KW - apren- KW - aprendizaje escolar KW - co-creation value KW - constructivismo KW - curicculum KW - delphi technique KW - dizaje escolar KW - employability skills KW - employees KW - employers KW - enfoques socioculturales KW - engineering KW - fracaso escolar KW - fracaso escolar. KW - industry KW - kebolehpasaran KW - kemahiran ’employability’ KW - malaysia Industry 4.0 forth industry revolution KW - manufacturing industry KW - mysms KW - pendidikan teknikal KW - pendidikan tinggi KW - psicología educacional KW - service sciences KW - technical graduates KW - technical institutions PY - 2018 SN - 9789672231035 TI - La corrupcion y la contratacion directa UR - https://www.uam.es/gruposinv/meva/publicaciones jesus/capitulos_espanyol_jesus/2005_motivacion para el aprendizaje Perspectiva alumnos.pdf%0Ahttps://www.researchgate.net/profile/Juan_Aparicio7/publication/253571379_Los_estudios_sobre_el_cambio_conceptual_ ER - TY - GEN AB - La Corrupción en Colombia, aproximaciones conceptuales y metodológicas para abordarla Un análisis de las entidades de control e investigación y estudio de AU - Villamil, Jesús Emerio PY - 2017 SP - 11 EP - 177 TI - La corrupción en Colombia, aproximaciones conceptuales y metodológicas para abordarla. Un análisis de las entidades de control e investigación y estudio de casos 2010-2014 UR - http://bdigital.unal.edu.co/57082/1/74261112.2017.LaCorrupcionenColombiaaproximacionesconceptualesymetodologicasparaabordarla.pdf ER - TY - JOUR AU - Martínez, Edgar E. AU - Ramírez, Juan M. IS - 15 KW - contratación estatal KW - corrupción KW - costo de transacción KW - neoinstitucionalismo KW - soborno PY - 2006 SP - 148 EP - 162 TI - La corrupción en la contratación estatal colombiana -una aproximación desde el neoinstitucionalismo- T2 - Reflexión Política UR - http://revistas.unab.edu.co/index.php?journal=reflexion&page=article&op=view&path%5B%5D=622&path%5B%5D=598 VL - 8 ER - TY - JOUR AB - This reflection article was born based on a master's thesis of the Political Studies program entitled: " War and Formation of the State in Colombia, " which is based on the assumption that political violence (war, more specifically), is a crucial element to form modern States since this activity promotes institutional development typical of modern times. This document is an ap-proach to the origin of the Colombian state and weakness of its coercive institutions, which has partially prevented from obtai-ning monopoly of legitimate violence. For this reason, coercive institutions in Colom-bia devoted to war have found themselves obliged to face internal conflicts and have most of the time left reflections on inters-tate conflicts aside. AU - Mario, Carlos AU - Meneses, Berrío IS - 3 KW - Coerción KW - Colombia KW - Estado moderno KW - Guerra KW - Modern state KW - coercion KW - war PY - 2013 SP - 85 EP - 106 TI - La formación del Estado en Colombia y el origen histórico de su debilidad coercitiva. Algunas aproximaciones T2 - Ciencias Sociales y Educación VL - 2 ER - TY - RPRT AU - Corporación Transparencia por Colombia PY - 2019 SP - 96 EP - 96 TI - Así se mueve la corrupción: radiografía de los hechos de corrupción en Colombia T2 - Monitor ciudadano de la Corrupción ER - TY - GEN AB - Predicting the binding mode of flexible polypeptides to proteins is an important task that falls outside the domain of applicability of most small molecule and protein−protein docking tools. Here, we test the small molecule flexible ligand docking program Glide on a set of 19 non-α-helical peptides and systematically improve pose prediction accuracy by enhancing Glide sampling for flexible polypeptides. In addition, scoring of the poses was improved by post-processing with physics-based implicit solvent MM- GBSA calculations. Using the best RMSD among the top 10 scoring poses as a metric, the success rate (RMSD ≤ 2.0 Å for the interface backbone atoms) increased from 21% with default Glide SP settings to 58% with the enhanced peptide sampling and scoring protocol in the case of redocking to the native protein structure. This approaches the accuracy of the recently developed Rosetta FlexPepDock method (63% success for these 19 peptides) while being over 100 times faster. Cross-docking was performed for a subset of cases where an unbound receptor structure was available, and in that case, 40% of peptides were docked successfully. We analyze the results and find that the optimized polypeptide protocol is most accurate for extended peptides of limited size and number of formal charges, defining a domain of applicability for this approach. AU - Mendoza, Lizeth DO - 10.1017/CBO9781107415324.004 IS - 9 KW - icle PY - 2014 SN - 9788578110796 SP - 1689 EP - 1699 TI - Efectividad de la ley de garantias electorales 996 de 2005 VL - 53 ER - TY - GEN AU - Cuervo Serrano, Aldemar PY - 2014 SP - 1 EP - 37 TI - Corrupción en la contratación pública en Colombia ER - TY - JOUR AU - Leal-hernandez, Abelardo IS - 2 KW - corrupción administrativa KW - erario público KW - sanción prevención KW - tipos penales PY - 2016 SP - 68 EP - 78 TI - Corrupción administrativa en la contratación pública T2 - Revista criterio libre juridico VL - 13 ER - TY - GEN AB - Sancionada el jueves en la noche ENTRA EN VIGENCIA LEY DE GARANTÍAS Bogotá, 25 nov. (SNE).-El ministro del Interior y de Justicia, Sabas Pretelt de la Vega-como delegatario de las funciones presidenciales-sancionó el jueves la ley número 996 o de garantías electorales que reglamenta la reelección presidencial, la participación de los servidores públicos y las garantías a la oposición. El siguiente es el texto completo de la ley: LEY No. 996 24 Nov. 2005 por medio de la cual se reglamenta la elección de Presidente de la República, de conformidad con el artículo 152 literal f) de la Constitución Política de Colombia, y de acuerdo con lo establecido en el Acto Legislativo 02 de 2004, y se dictan otras disposiciones. El Congreso de Colombia DECRETA: T I T U L O I DISPOSICIONES GENERALES Artículo 1º. Objeto de la ley. La presente ley tiene como propósito definir el marco legal dentro del cual debe desarrollarse el debate electoral a la Presidencia de la República, o cuando el Presidente de la República en ejercicio aspire a la reelección, o el Vicepresidente de la República aspire a la elección presidencial, garantizando la igualdad de condiciones para los candidatos que reúnan los requisitos de ley. Igualmente se reglamenta la Participación en política de los servidores públicos y las garantías a la oposición. Artículo 2º. Campaña presidencial. Se entiende por campaña presidencial el conjunto de actividades realizadas con el propósito de AU - Congreso de Colombia TI - Ley 996 de 2005 ER - TY - GEN AU - Banco de la República PY - 2015 TI - Historia electoral en Colombia T2 - Banco de la Republica UR - https://enciclopedia.banrepcultural.org/index.php/Historia_electoral_en_Colombia ER - TY - JOUR AB - Resumen El artículo presenta una aproximación a la caracterización del lugar que se le ha dado y del perfil con que se ha configurado el elector colombiano. A partir de la metodología del estado de arte, analiza la literatura más relevante que se ha producido en torno a la relación elecciones-partidos políticos-elector y señala las categorías de énfasis que se han privilegiado. Además, a partir del establecimiento de las razones de la decisión y de la orientación del voto, enlista algunos de los factores que, desde motivaciones muy particulares-cívicas (deber ser del ciudadano), cínicas (ser de la contraprestación)-, inducen al elector a su participación. Palabras clave AU - Arteaga Villa, Víctor KW - Colombia KW - Comportamiento Electoral KW - Elector KW - Participación Electoral KW - Proceso Electoral PY - 2011 SP - 75 EP - 94 TI - Hacia una caracterización del lugar y el perfil del elector colombiano T2 - Estudios Políticos VL - 39 ER - TY - GEN AU - Señal Colombia PY - 2019 TI - 200 años de historia electoral en Colombia T2 - Señal Colombia UR - https://www.senalmemoria.co/articulos/200-anos-de-historia-electoral-en-colombia ER - TY - GEN AU - Registraduria PY - 2020 TI - Historia del voto en Colombia - Registraduría Nacional del Estado Civil T2 - Registraduria Nacionla del estado civil UR - https://www.registraduria.gov.co/-Historia-del-voto-en-Colombia-.html ER - TY - JOUR AU - Gomez Lobo, Alirio PY - 2010 TI - La elecciones en colombia T2 - Revista estudios sociojuridicos ER - TY - JOUR AU - Delgado, Oscar IS - 1 PY - 2010 SP - 33 EP - 68 TI - Regimenens electorales en america latina, el caribe y europa oriental T2 - Estudios Socio-Jurídicos VL - 1 ER - TY - GEN AU - El tiempo PY - 2016 TI - La historia del voto en Colombia, un derecho que no fue fácil de lograr UR - https://www.eltiempo.com/archivo/documento/CMS-7730934 ER - TY - JOUR AB - precio y el valor de la democracia en Bogotá. El caso de las elecciones a la alcaldía mayor de Bogotá en 2015". Colombia. Contacto: juan.hernandez@unimilitar.edu.co 2. Profesional en Relaciones Internacionales y Estudios Políticos de la Universidad Militar Nueva Granada. Joven investigador del proyecto de investigación "El precio y el valor de la democracia en Bogotá. El caso de las elecciones a la alcaldía mayor de Bogotá Resumen El presente artículo pretende exponer el funcionamiento de la democracia electoral en Colombia, desde la teoría competitiva de John Schumpeter. A partir del acontecer histórico nacional se pretende comprender cuál es el impacto y qué significa el proceso de elecciones en esta sociedad. Como la intención es comprender cómo se ha desarrollado la democracia en Co-lombia, es necesario definir en un primer momento los conceptos claves para entender qué es democracia, específicamente la electoral y competi-tiva. A continuación, analizar el comportamiento electoral en Colombia, a través de datos cuantitativos y cualitativos sobre las últimas elecciones, respecto a temas como legitimidad, valor y abstencionismo; variables que permitirán identificar cuáles son las principales debilidades para la demo-cracia en el país. Con la intención de aplicar el alcance teórico, se hará un breve análisis acerca del comportamiento político en Bogotá, como capital del país y como centro del movimiento político nacional, esto permitirá alcanzar una comprensión valiosa sobre la democracia en Colombia. Palabras Clave. Comportamiento electoral; democracia; democracia competitiva; democracia electoral. Abstract This article aims to pose the functioning of electoral democracy in Colom-bia, based on John Schumpeter's Competitive Theory. From the national historic events, it is intended to understand what the impact is and what the election process means in this society. Since the intention is to understand how democracy has developed in Colombia, it is necessary to define at first the key concepts to understand what democracy is, specifically the electoral and competitive one. Then, to analyze the electoral behavior in Co-lombia, through quantitative and qualitative data on the latest elections, regarding issues, such as legitimacy, value, and absenteeism. These variables will allow us to identify the main weaknesses for democracy in the country. With the intention of applying the theoretical scope, a brief analysis about the political behavior in Bogotá will be made, as being the capital city of the country and as the center of the national political movement, this will allow to achieve a valuable understanding on the democracy in Colombia. AU - Hernandez Diaz, Juan Carlos AU - Echeverri Martinez, Laura Milena DO - 10.21500/16578031.3829 IS - 2 KW - Competitive Democracy KW - Democracy KW - Voting Behavior KW - and Voting Democracy PY - 2018 TI - Democracia electoral en Colombia desde una visión de competencia UR - http://dx.doi.org/10.21500/16578031.3829 VL - 18 ER - TY - RPRT AB - El proyecto político de la modernidad es la democracia, entendida como el poder del pueblo, es decir, la democracia postula como fun-damento último de la legitimidad del poder político la aplicación del principio de la soberanía popular. La fuente del poder en el sistema democrático es la participación de la ciudadanía, la cual deberá otor-gar, mediante su presencia, un carácter legítimo a todas las institucio-nes que ejercen poder para la organización del sistema económico, social y político. La democracia es una creación humana más allá de toda explica-ción o fundamentación religiosa o extrasocial. La democracia se ex-plica y responde por sí misma. La democracia como sistema político y de organización social prescinde de toda explicación por fuera de la libre voluntad de los ciudadanos, del pueblo. El sistema democrático renuncia a una fun-damentación por fuera de la sociedad y de la historia. Para llegar hasta allí, el poder como sistema de organización política tuvo que despo-jarse de la legitimación sobre todo de origen religioso. Una primera característica de la democracia es que ella se postula como creación humana y como sistema autofundado, esto es, como verdadera creación política, como un conjunto de ideas, de institucio-nes y de prácticas que constituyen una invención colectiva. La demo AU - Santana, Pedro PY - 2011 TI - Modernidad y Democracia, bases del pensamiento politico moderno y democratico ER - TY - JOUR AB - RESUMEN: El presente artículo analiza, de manera exploratoria, la relación de mutua causalidad entre el comportamiento electoral y la simpatía partidista de los ciudadanos bogotanos como proxy de su identidad partidista. Específicamente, se plantea cómo la simpatía partidista incide en la decisión de voto de los ciudadanos, y cómo dicha decisión asimismo afecta su simpatía por un partido político. El análisis desarrollado permite concluir que en sistemas políticos con partidos poco disciplinados, el voto programático no es decisivo en los comicios, por lo que es más factible encontrar una mayor fuerza de asociación entre la decisión de voto y la simpatía partidista después de las elecciones, que viceversa. PALABRAS CLAVE: elecciones • comportamiento político • voto (Thesaurus) • simpatía partidista (palabras clave autor) H Este artículo surge a partir del trabajo de grado sustentado en noviembre de 2014 para optar al título de Magíster en Ciencia Política de la Universidad de los Andes (Colombia). El artículo no contó con financiación. AU - Camila, María AU - Amaya, Angulo DO - 10.7440/colombiaint86.2016.03 TI - Intención de voto y simpatía partidista en Bogotá UR - http://dx.doi.org/10.7440/colombiaint86.2016.03 ER - TY - RPRT AB - Teniendo en cuenta la importancia que revisten la democracia y la participación ciudadana como pilares del estado social de derecho y, por ende, de nuestro ordenamiento constitucional, la Fundación Hanns Seidel-Colombia, cumpliendo con su objetivo de contribuir al fortalecimiento de la democracia en nuestro país y con ello de respaldar los proyectos e iniciativas que permitan contribuir a tal fin, ha apoyado la elaboración de la presente publicación, la cual se constituye en un reflejo del interés que tiene la academia por reflexionar sobre asuntos de especial relevancia y actualidad, de cara a los retos que a diario asume nuestro país en el desarrollo de los elementos que nos permitan hablar de una demo-cracia sólida y de una garantía de la participación ciudadana, en sus diversas perspectivas. En ese sentido, el libro "Retos de la democracia y de la participación ciudadana" es producto de un conjunto de reflexiones, tras percibir que, pese a la importancia que la carta política concedió a la democracia y al principio, valor y derecho fundamental de participación ciudadana, existen proble-mas conceptuales, retos y perspectivas que han influido en su desarrollo, así como también en los mecanismos legales de participación del pueblo en ejercicio de su soberanía y de la participación ciudadana con proyección social. La contribución académica indaga las razones que llevaron al constitucionalismo colombiano a adoptar el modelo participativo de la democracia, estudia las condiciones necesarias para su exitosa implementación y reflexiona sobre las dificultades y riesgos de su puesta en marcha. En el mes de septiembre de 2011 se realizó en la Universidad del Rosario el Primer Concurso Nacional de Semilleros de Investigación, en el marco del Seminario Internacional "Veinte Años de Constitucionalismo Social", organizado con ocasión del vigésimo aniversario de la Constitución Política. En total se presentaron 41 ponencias, de las cuales 36 fueron seleccionadas para participar en el concurso. En este volumen se reúnen las ponencias de los estudiantes que obtuvieron los primeros tres puestos en el concurso. Conscientes de la importancia de fomentar entre los estudiantes el estudio de temas relacionados con la democracia, la participación ciudadana y los derechos humanos, desde distintas visiones del derecho, la Fundación Hanns Seidel y el Observatorio Legislativo de la Universidad del Rosario aunaron esfuerzos para crear la presente colección, dedicada a recoger en sus páginas los estudios y las reflexiones de los estudiantes de derecho. El propósito es apoyar, en primer término, el fortalecimiento de la democracia por medio del estudio de sus bases y principios, y en segundo lugar, el desarrollo de la labor de investigación formativa, hoy tan importante en la enseñanza del derecho. Cada año, esta colección recogerá las ponencias seleccionadas por pares académicos de alto nivel, después de valorar los criterios básicos de publicación del nivel formativo. El llamado se dirige, pues, a todos los estudiantes de Derecho, para que dediquen tiempo de su formación académica y profesional a la investigación de temas de especial relevancia en nuestra nación, y para que aporten, desde su rol, a la construcción de un mejor país. Conscientes de la importancia de ser, desde la academia, una herramienta de formación social y de trabajar conjun-tamente con quienes confían en la Democracia y sus procesos, el Observatorio Legislativo de la Facultad de Jurisprudencia de la Universidad del Rosario y la Fundación Hanns Seidel, han diseñado esta sencilla publicación para poner en manos de toda la comunidad los conceptos básicos sobre nuestra legislación actual en materia electoral y política, conociendo de primera fuente la más reciente Reforma Constitucional de nuestro país (Acto Legislativo 01/09). Además, la publicación tiene por objeto llevar a todas las personas las herramientas necesarias y los elementos básicos relacionados con las Elecciones Legislativas del próximo 14 de marzo de 2010. La Universidad, en ejercicio de su misión de formación en todos los niveles, ha realizado esta publicación partiendo de la base de que la piedra angular de nuestro esquema democrático es la participación en la elección de quienes nos representan en el ejercicio del poder legislativo y de quienes nos gobiernan. Por esa razón, consideramos indispensable y pertinente dar a conocer de forma concreta los conceptos propios de la actividad electoral y, de esa manera, generar en los miem-bros de la comunidad la tranquilidad de ejercer el derecho al voto de forma respon-sable, crítica y estructurada. Esta publicación resuelve dudas elementales que los electores pueden tener a la hora de votar y brinda los conocimientos esenciales para ir a las urnas con tranqui-lidad. ¡Porque votar es un derecho y un deber de todos! Para la realización de esta publicación, contamos con la gentil colaboración de la Registraduría Nacional del Estado Civil. Colección Textos de Jurisprudencia NUEVA REFORMA POLÍTICA Y PROCESO ELECTORAL DEL AÑO 2010 Aspectos básicos para votar en las Elecciones Legislativas de 2010 AU - Araujo Oñate, Rocio AU - Torres Villareal, Maria Lucia TI - Retos de la democracia y de la participación ciudadana ER - TY - RPRT AU - Franco-Cuervo Javier Andrés Flórez Henao OPE, Beatriz PY - 2009 TI - Participación electoral: radiografía teórica y práctica de un fenómeno en Colombia ER - TY - RPRT AB - A. Introducción Los actuales desafíos para la democracia colombiana son quizás los más determinantes de los enfrentados en la historia reciente del país. El frustrado proceso de los diálogos para la resolución del conflicto armado y su posterior rompimiento, los graves problemas derivados del narcotráfico y la producción de drogas psicotrópicas, y sus implicaciones en la convivencia ciudadana, la precariedad de lo público, la crisis de lo político y los partidos, la frágil institucionalidad y representatividad democrática del Estado, la desactivación productiva que viene de tiempo atrás pero que se ve agravada por la falta de dinamismo del sector terciario y de recursos naturales en el último quinquenio, la agudización de la exclusión social con elevados niveles de desempleo y pobreza representan algunos de los serios problemas que requieren enormes esfuerzos y acciones integrales por parte de la ciudadanía, el gobierno y el apoyo de la comunidad internacional. AU - Jorge Garay, Luis TI - Crisis, exclusión social y democratización en Colombia ER - TY - JOUR AU - Garay, Luis Jorge PY - 2003 SP - 52 EP - 77 TI - Crisis, exclusion social y democratizacion en colombia T2 - Revista Prospectiva VL - 8 ER - TY - RPRT AU - Garcia Sanchez, Miguel AU - Montalvo, Jorge Daniel AU - Seligson, Mitchell A. PY - 2015 SP - 161 EP - 161 TI - Cultutra politica de la democracia en colombia 2005: actitudes deocraticas en zonas de consolidacion territorial ER - TY - JOUR AU - Garcia Jurado, Roberto PY - 2003 SP - 7 EP - 24 TI - La teoría democrática de Huntington T2 - Política y Cultura UR - http://www.redalyc.org/articulo.oa?id=26701902 VL - 19 ER - TY - JOUR AU - Madrigal garzon, Alexander Emilio IS - 1 PY - 2011 SP - 219 EP - 235 TI - La formación del estado-nación en Colombia durante el siglo XIX: el trazado histórico-social de la institución del orden político T2 - PERSPECTIVAS INTERNACIONALES VL - 7 ER - TY - BOOK AU - Barrios Cabrera Directora Nacional, Alejandra AU - Mancera Morales, Camilo AU - Salazar Escalante, Luisa AU - del Rosario Perea Garcés, María AU - Pabón Castro, Marlon AU - Angarita Serrano Orlando Higuera Torres, Gabriel AU - Murcia Sánchez Diseño diagramación Eric Javier Muñoz Pérez, Fernando SN - 978-958-59221-5-0 TI - Autores Camilo Mancera Morales Coordinador Observatorio de Justicia Electoral UR - www.daodigital.com.co ER - TY - JOUR AU - Ochoa Villa, Roberto IS - 1 PY - 2015 SP - 209 EP - 220 TI - Comportamiento electoral de los colombianos durante las elecciones presidenciales del año 2010 T2 - Jurídicas CUC VL - 11 ER - TY - JOUR AU - Peña Contreras, Sonia Lucia PY - 2007 SP - 191 EP - 230 TI - Sistema politico y democracia en colombia, redes de inclusion en los años sesenta y noventa una aproximacion desde la teoria de los sistemas T2 - Revista dialogos y saberes VL - 26 ER - TY - JOUR AB - Redefiniendo la democracia. Los orígenes de la democracia competitiva: J. Schumpeter. Carlos Manuel Rodríguez Arechavaleta ntre las numerosas paradojas y grandes interrogantes que el incipiente siglo XXI trae al hombre, la redefinición de la democracia en sociedades siempre plurales y complejas ocupa un lugar central. E Si reconocemos que doctrinas contrapuestas respecto de sus objetivos básicos coinciden en considerar que la democracia es componente central de sus proyectos políticos, asumiremos que el concepto de democracia no refiere a una ideología específica diferenciable de otras, sino a formas y mecanismos reguladores del ejercicio del poder político. En este sentido, la democracia trasciende a las ideologías; sin embargo, se debe reconocer que el orden y los procedimientos democráticos no son ajenos al dispositivo simbólico en el que se condensan los principios y valores asociados al sistema democrático (Serrano:997:511). AU - Manuel, Carlos AU - Arechavaleta, Rodríguez IS - 3 PY - 2007 SP - 1 EP - 15 TI - Redefiniendo la democracia. Los orígenes de la democracia competitiva: J. Schumpeter T2 - Revista de Ciencias Sociales de la Universidad Iberoamericana VL - 2 ER - TY - JOUR AB - IntroduccIón El modelo estatal colombiano escogido por el constituyente de 1991 corres-ponde al de un Estado Social de Derecho, concepto polisémico que implica un énfasis en lo social por parte del quehacer de la administración pública. Ello quiere decir que la parte orgánica del texto superior sólo adquiere sentido cuando está orientada a la satisfacción de los derechos y principios que aparecen consagrados en la parte dogmática del mismo 1 , en aras de que lo social, preci-samente, no se convierta en una "simple muletilla retórica que proporciona un elegante toque de filantropía a la idea tradicional del derecho y del Estado" 2. Por tal razón, la configuración de los organismos y autoridades que componen la parte orgánica de la Constitución deben gozar de legitimidad en el ejercicio del poder político, no sólo desde un punto de vista formal, a partir del cumpli-miento de unos requisitos externos y de alguna manera procedimentales, como lo son las elecciones libres, que buscan la autodeterminación del pueblo en claro acatamiento del principio democrático como soporte fundante del Estado Social de Derecho 3 ; sino también, de forma material, en tanto que exista esa 1 Sentencia T-406 de 1992 de la Corte Constitucional de Colombia, M.P. Ciro Angarita Barón. 2 Esta cita corresponde a la Sentencia T-406 de 1992 de la Corte Constitucional de Colombia, M.P. Ciro Angarita Barón. Sobre este punto también se pueden ver las siguientes sentencias de la misma Corte: Sentencia C-004 de 1992, M.P. Este aspecto queda aclarado en la Sentencia C-145 de 1994 de la Corte Constitucional de Colombia, M.P. Alejandro Martínez Caballero, la cual señala: "Al consagrar los derechos de participación, con-formación, ejercicio y control del poder político, la Constitución de 1991 abandona la idea-propia de las tesis relativas a la soberanía nacional-según la cual los ciudadanos ejercen el voto no como un derecho sino como una función electoral, tal y como lo establecía la Constitución derogada en su AU - Rúa Delgado, Carlos IS - 2 KW - Clientelism KW - Corruption KW - Legitimacy KW - State capture PY - 2013 SP - 85 EP - 122 TI - La legitimidad en el jercicio del poder politico en el estado social de derecho. Una revision desde el caso colombiano T2 - Revista Ius et Praxis UR - http://dspace.utalca.cl/ VL - 19 ER - TY - JOUR AB - C u a d e r n o s d e I n v e s t I g a C I ó n Abstención electoral en Colombia. AU - Patricia, Ana AU - Espinosa, Torres AU - Durá, Jaime Ferri TI - Desafección política, violencia política y conflicto armado ER - TY - CONF AB - Elecciones (2004) 4, 153 PROCLAMAR QUE no hay elecciones sin democracia es una afirmación erró-nea. En realidad, muchos gobiernos dictatoriales a lo largo de la historia han tenido que recurrir a las urnas para atender inquietudes sociales y así sobre-llevar su autoritarismo, aplacar hostilidades o subvertir ánimos de inspira-ción democrática. Aunque suene paradójico, es a través de estas elecciones menores que las dictaduras han buscado legitimarse, usándolas como palia-tivo para lograr climas sociales convenientes. Las dictaduras y la democracia pueden tener elecciones, pero una democracia debe tenerlas de manera lim-pia y periódica. También es recurrente escuchar que la democracia no es sólo elecciones, minimizando así el único mecanismo del que ésta nace. No siendo errónea, la frase es incompleta; por eso, es necesario afirmar, tam-bién, que no hay democracia sin elecciones. Las elecciones constituyen el mecanismo de alumbramiento y sosteni-miento del sistema democrático. Y lo son puesto que las elecciones, sobre todo, producen poder. Es más, al otorgar a los representantes elegidos la posibilidad de tomar decisiones, el poder debe nacer de elecciones limpias y transparentes que en verdad lo legitimen. En tal sentido, si la democracia tiene un precio, éste es el costo de cele-brar elecciones periódicas. La historia de las elecciones es la historia de la democracia y eso ha significado pasar de comicios que convocaban a pocos a procesos que involucran a millones de personas. Hoy en día, elegir no es más el privilegio de algunos. La práctica democrática del siglo XX supo que-brar prerrogativas e impulsar el derecho al voto universal, de las mujeres, de * Este artículo es una versión revisada de la ponencia presentada ante la X Conferencia de la Asociación de Organismos Electorales de América del Sur, Protocolo de Quito (Lima, 29 y 30 de enero de 2003). AU - Soldevilla, Fernando Tuesta PY - 2004 SP - 16 EP - 16 TI - La democracia tiene un costo: hacer elecciones T2 - X Conferencia de la Asociación de Organismos Electorales de América del Sur UR - www.onpe.gob.pe ER - TY - JOUR AB - Even as the Internet goes pop, federal policymakers continue to surrender their statutory obligation to regulate communications in the first instance to extralegal nongovernmental organizations comprised of technical experts. The Federal Communications Commissions conclusion that a major broadband service provider's network management practices were unreasonable is a case in point. There, in the absence of any decisive legislative or even regulatory guidance, the FCC turned principally to the engineering principles on which the Internet Engineering Task Force bases transmission standards: to wit, (1) decentralization, (2) interoperability, and (3) user empowerment. This impulse to defer as a matter of course to such an organization and its extralegal standards without any legal mechanism requiring as much is flawed. Of course, there is something to be said for an administrative regime that defers first-instance rulemaking authority on technologically complex matters to standard-setting organizations comprised of experts. Without more, however, such an approach fails to appreciate the foundational and uniquely public nature of communications in democracy. Historically, policymakers have required that communications governance be addressed one way or another to the public and its institutional political processes, and not insulated from them. At a minimum, policymakers should be required to explicitly substantiate their hopeful assumption that the pertinent non-governmental standard-setting organizations have democratically legitimated authority to regulate in the first instance. This article is chiefly a critique of the prevailing "technological" and "economic" approaches to Internet governance. It then sketches a "participatory" approach that is attentive above all to civic-minded concerns outside of the competence of technological and economic expertise: namely, (1) universal access and (2) the circulation of issues of local and common concern. AU - Sylvain, Olivier A. KW - democracia KW - gobernanza KW - legitimidad KW - redes PY - 2010 SP - 96 EP - 107 TI - Internet Governance and Democratic Legitimacy T2 - Fed. Comm. L.J. 205 VL - 33 ER - TY - JOUR AU - Bovero, Michelangelo PY - 2012 SP - 317 EP - 351 TI - ¿Elecciones sin democracia ? ¿Democracia sin elecciones ? Sobre las formas de la participación política T2 - Revista Justicia Electoral UR - https://dialnet.unirioja.es/servlet/articulo?codigo=4725571 ER - TY - GEN AU - Merchan Chaverra, Maria Alejandra PY - 2012 SP - 29 EP - 29 TI - Historia del derecho al sufragio en colombia UR - http://www.semana.com ER - TY - GEN AB - en ejercicio de su poder soberano, representado por sus delegatarios a la Asamblea Nacional Constituyente, invocando la protección de Dios, y con el fin de fortalecer la unidad de la Nación y asegurar a sus integrantes la vida, la convivencia, el trabajo, la justicia, la igualdad, el conocimiento, la libertad y la paz, dentro de un marco jurídico, democrático y participativo que garantice un orden político, económico y social justo, y comprometido a impulsar la integración de la comunidad latinoamericana decreta, sanciona y promulga la siguiente CONSTITUCION POLITICA DE COLOMBIA TITULO I DE LOS PRINCIPIOS FUNDAMENTALES Artículo 1. Colombia es un Estado social de derecho, organizado en forma de República unitaria, descentralizada, con autonomía de sus entidades territoriales, democrática, participativa y pluralista, fundada en el respeto de la dignidad humana, en el trabajo y la solidaridad de las personas que la integran y en la prevalencia del interés general. Artículo 2. Son fines esenciales del Estado: servir a la comunidad, promover la prosperidad general y garantizar la efectividad de los principios, derechos y deberes consagrados en la Constitución; facilitar la participación de todos en las decisiones que los afectan y en la vida económica, política, administrativa y cultural de la Nación; defender la independencia nacional, mantener la integridad territorial y asegurar la convivencia pacifica y la vigencia de un orden justo. Las autoridades de la República están instituidas para proteger a todas las personas residentes en Colombia, en su vida, honra, bienes, creencias, y demás derechos y libertades, y para asegurar el cumplimiento de los deberes sociales del Estado y de los particulares. Artículo 3. La soberanía reside exclusivamente en el pueblo, del cual emana el poder público. El pueblo la ejerce en forma directa o por medio de sus representantes, en los términos que la Constitución establece. Artículo 4. La Constitución es norma de normas. En todo caso de incompatibilidad entre la Constitución y la ley u otra norma jurídica, se aplicarán las disposiciones constitucionales. AU - Congreso de la republica PY - 1991 TI - Constitucion politica de Colombia ER - TY - GEN AU - Corte constitucional PY - 1992 TI - T-406-92 Corte Constitucional de Colombia UR - https://www.corteconstitucional.gov.co/relatoria/1992/t-406-92.htm ER - TY - JOUR AB - La contratación estatal en Colombia ha sido configurada en el marco de principios que orienten dicha actividad, incluido el principio de planeación. Este principio es palpable por medio de la revisión de sentencias del Consejo de Estado y la Corte Constitucional, así como por la doctrina, en donde se desa-rrolla la interpretación del citado principio en cuanto a su concepto y alcance, entre otros, sin embargo, dicho principio no ha sido tipificado en la debida forma en el marco normativo de la contratación pública. No obstante, después de una revisión sistematica de las normas aplicables y de las fuentes juris-prudenciales, así como doctrinales, se hace posible su identificación. En el presente artículo se advierte la existencia de un principio de planeación para la contratación estatal colombiana, resultado de un proceso sistematico de interpretación de las fuentes, así como las consecuencias de su no aplicación en el proceso contractual. Es por ello que el principio de planeación es considerado la piedra angular de la contratación estatal, en atención a su ropaje como engranaje central del proceso. AU - Amaya Rodriguez, carlos Fernando PY - 2016 SP - 105 EP - 119 TI - El principio de planeación en la contratación estatal, un principio no tipificado T2 - Revista VIA IURIS VL - 20 ER - TY - RPRT AU - Departamento nacional de planeación PY - 2018 TI - plan nacional de desarrollo 2018-2022 UR - www.dnp.gov.co ER - TY - RPRT AU - Zuluaga, Suárez AU - María, Luisa KW - Alcances KW - Contrato estatal KW - Dimensión financiera KW - Dimensión jurídica KW - Dimensión técnica KW - Nulidad absoluta KW - Planeación KW - Principio KW - Violación PY - 2016 TI - Alcances del principio de planeación en la contratación estatal, en sus dimensiones técnica, jurídica y financiera ER - TY - GEN AB - RESUMEN En este artículo de reflexión se realiza un análisis de los principios que reglamentan el Derecho de contratación Estatal, entre los que resaltamos la importancia del principio de planeación, que resulta tener más relevancia dentro del proceso de selección del contratista. De igual forma se estudia la naturaleza jurídica, funciones, propósitos y competencia de la Agencia Nacional de contratación. Con el fin de estudiar el principio de planeación en medio del proceso de selección del contratista, se examina la estructura normativa y operativa de los acuerdos marco de precios suscritos por la Agencia Nacional de contratación. Por ultimo con el propósito de verificar la incidencia del principio de planeación en el proceso de selección del contratista, se analizaran algunos de las situaciones que afectan el principio de planeación en los acuerdos marco de precio y su posible solución. ABSTRACT This article reflects on the principles that regulate the law of State contracting, among which the importance of the planning principle, which has more relevance in the selection process of the contractor, is highlighted. The legal nature, functions, purposes and competence of the Agencia Nacional de contratación are also studied. In order to study the principle of planning in the process of contractor selection process, examine the regulatory and operational structure of the framework price agreements signed by the Agencia Nacional de contratacion. Finally, in order to verify the impact of the planning principle on the selection process of the contractor, they will analyze some of the situations that affect the planning principle in the price framework agreements and their possible solution. . AU - Barrera Portela, Cristian Andres KW - Palabras Claves: contratación KW - advocacy KW - incidencia KW - planeación KW - planning KW - principio KW - principle KW - proceso KW - process KW - selección Keywords: recruitment KW - selection PY - 2016 TI - La incidencia del princiio de planeacion en el proceso de selección ER - TY - RPRT AU - Misión de Observación Electoral PY - 2019 SP - 519 EP - 519 TI - Mapas y factores de riesgo electoral Elecciones de autoridades locales Colombia ER - TY - GEN AU - Fiscalización, Área AU - La, D E AU - De, Secretaría AU - Departamental, Hacienda AU - Tolima, Del PY - 2019 SP - 63 EP - 63 TI - Propuesta de organizacion y control de procesos en el area fiscalizacion de la secreatria de hacienda departametal del Tolima ER - TY - JOUR AB - Farfán, C.; Mosquera, Y. (2015). Propuesta metodológica para aumentar el recaudo tributario en el municipio de Quibdó. Este artículo es resultado de la investigación titulada "Propuesta metodológica para aumentar la eficiencia en el sistema tributario del municipio de Quibdó", la cual fue desarrollada por las autoras entre enero y diciembre de 2012, como su trabajo de grado en la Maestría en Tributación y Política Fiscal, de la Universidad de Medellín. El trabajo fue orientado por el profesor Hugo A. Macías, en el marco de la maestría. AU - Farfan Rodriguez, Juliana Carolina AU - Mosquera Restrepo, Yessica Leonor PY - 2015 SP - 81 EP - 112 TI - Propuesta metodológica para aumentar el recaudo tributario en el municipio de Quibdó T2 - Cont. udea VL - 66 ER - TY - JOUR AU - Restrepo Lizarazo, John Jairo AU - Hernandez Murillo, Benito AU - Moreno Gaviria, Nelly Johana IS - 1 PY - 2013 TI - evaluacion de la eficacia en el recaudo del impuesto al degüello de ganado mayor, sacrificado en el municipio de Florencia, en los periodos fiscales 2009-2010 T2 - Revista Faccea VL - 3 ER - TY - GEN AU - López Rendon, Jorge Andres PY - 2014 SP - 102 EP - 102 TI - Análisis estratégico de los tributos departamentales mediante modelamiento y simulación utilizando Dinámica de Sistemas. Aplicación al Impuesto sobre Vehículos Automotores ER - TY - JOUR AU - Carin, A.A. & Sund, R.B IS - 1 KW - jel classification KW - l25 KW - m11 KW - performance KW - supply chain integration KW - supply chain management PY - 2018 SP - 430 EP - 439 TI - INFORME FISCAL Y FINANCIERO A ABRIL 2018 SECRETARIA DE HACIENDA DEPARTAMENTAL ER - TY - GEN AU - Lora, Eduardo AU - Cardenas, Mauricio KW - América Latina KW - Instituciones KW - politicas fiscales PY - 2006 SP - 247 EP - 277 TI - La reforma de las instituciones fiscales en América Latina UR - http://publications.iadb.org/bitstream/handle/11319/2167/La reforma de las instituciones fiscales en América Latina.pdf?sequence=1 ER - TY - GEN AU - Gobernacion de Boyaca PY - 2005 SP - 1 EP - 4 TI - Impuesto al Degüello de Ganado Mayor en el Departamento de Boyacá ER - TY - JOUR AU - Suarez, Marilu PY - 2013 TI - AUDITORIA ESPECIAL DE RENTAS DEPARTAMENTALES Y MUNICIpal T2 - آب و خاک ER - TY - RPRT AU - Gobernacion de cundinamarca PY - 1997 SP - 1 EP - 1 TI - Ordenanza 024 de 1997 ER - TY - GEN AB - LA ASAMBLEA NACIONAL CONSTITUYENTE Y LEGISLATIVA Sobre descentralización administrativa DECRETA: ARTICULO 1o. Serán en lo sucesivo Rentas Departamentales, además de las que lo eran antes de la expedición de la Ley 1 de 1908 y que no estén cedidas a los Municipios, las de Licores Nacionales, Degüello de Ganado Mayor, Registro y Anotación. Las Rentas de Licores Nacionales comprende aquellas que en la actualidad la constituyen. Respecto de los vinos de producción nacional pueden los Departamentos declararlos incluidos o no en dicha Renta. La Renta de Degüello de Ganado Mayor la constituye un impuesto que no puede exceder de dos pesos oro para el macho y de dos pesos cincuenta centavos oro para la hembra, sobre cada res bovina que se dé al consumo. PARAGRAFO. La Renta de Fabricación de Cigarrillos continuará siendo nacional. PARAGRAFO. La Renta de Tabaco, como renta nacional, se hará efectiva únicamente sobre el consumo del artículo. En tal virtud son completamente libres la producción y exportación del tabaco del país. ARTICULO 2o. Son bienes de los Departamentos los que les pertenecían antes de la vigencia de la Ley 1 de 1908. Las nuevas secciones distribuirán entre sí dichos bienes, y en caso de desacuerdo entre ellas, lo decidirá el Ministerio de Hacienda y Tesoro. ARTICULO 3o. Los Consejos Administrativos Departamentales arreglarán todo lo relativo a organización, recaudación, manejo e inversión de las Rentas expresadas y a la formación y recaudación de cuentas de los responsables, como también a la represión y castigo del fraude. En tal virtud podrán disponer que se administren directamente tales rentas, o que se den en arrendamiento por medio de remates celebrados con las formalidades legales. PARAGRAFO. Caso de que los gobiernos Departamentales resuelvan dar en arrendamiento la Renta de Licores, los remates de dicha Renta se harán por Municipios. ARTICULO 4o. En los Departamentos en donde antes del año de 1905 no existía el monopolio de licores nacionales, queda definitivamente abolido el monopolio y substituido por el Impuesto de Patentes, El Gobernador y el Consejo Administrativo de cada Departamento organizarán este Impuesto, de manera que se consulten los intereses del Fisco y el ejercicio libre de la industria. En los Departamentos, Provincias o Municipios en donde el monopolio de licores nacionales esté arrendado, las disposiciones de este artículo se declararán en vigencia desde que los contratos de arrendamiento, anteriormente celebrados, terminen, o los contratistas los rescindan sin gravamen para el Tesoro Público. ARTICULO 5o. Lo dispuesto en la segunda parte del artículo anterior no comprende a los Departamentos en donde existía el monopolio de licores antes de 1905. ARTICULO 6o. Los Departamentos quedan subrogados a la Nación en todos los derechos y obligaciones provenientes de los contratos de arrendamiento que estén vigentes en relación con dichas rentas. AU - Asamblea Nacional constituyente y legislativa PY - 1909 TI - Ley 8 de 1909 ER - TY - RPRT AU - DANE PY - 2019 SP - 1 EP - 1 TI - Encuesta de Sacrificio de Ganado (ESAG) IV trimestre de 2019 ER - TY - JOUR AB - Resumen Este documento realiza una estimación del inventario ganadero bovino en Colombia, tendiente a dar luces sobre la probabilidad de las políticas de desarrollo ganadero en el país, básicamente con miras a aportar instrumentos metodológicos como modelos Arima y otros modelos de series de tiempo en la estimación del inventario ganadero en Colombia. El análisis comienza con una revi-sión de la importancia de la ganadería en la teoría del desarrollo económico, para luego continuar con la estimación de métodos de estimación univariada sobre las probabilidades de alcanzar los inventarios de ganado bovino de acuerdo al plan de desarrollo ganadero hacia el 2019 en concor-dancia con el desarrollo sectorial y nacional. Palabras clave: Ganadería, desarrollo rural, inventario ganadero, modelos de series de tiempo. Abstract This document makes an estimation of the bovine cattle inventory in Colombia, tend to give lights on the probability of the policies of cattle development in the country, basically with a view to contributing methodological instruments like Arima models and other models of series of time in the estimation of the cattle inventory in Colombia. The analysis begins with a revision of the importance of the cattle ranch in the theory of the economic development, then continues with the estimation of methods of estimation univariate on the probabilities of reaching the inventories of bovine cattle according to the plan of cattle development towards the 2019 in agreement with the sectorial and national development. AU - Cuenca Jimnez, Noel Jose AU - Chavarro Miranda, Fernando AU - Diaz Gantiva, Oscar Humberto KW - Arima Models and time series KW - Cattle KW - rural development PY - 2008 SP - 165 EP - 177 TI - El sector de ganaderia bovina en colombia. aplicación de modelos de series de tiempo al invetario ganadero T2 - rev.fac.cienc.econ VL - 1 ER - TY - GEN AU - Escobar Porras, Sebastian AU - Rojo Zapata, Andres Eduardo PY - 2015 SP - 37 EP - 37 TI - El sacrificio de ganado en Colombia: Una caracterizacion desde las series de tiempo ER - TY - RPRT AU - Galvis Aponte, Luis Armando PY - 2000 SP - 29 EP - 29 TI - Documentos de trabajo sobre economia regional: en Colombia: Un análisis La demanda de carnes econométrico ER - TY - GEN AU - De Salud, Ministerio AU - Protección, Y PY - 2012 SP - 11 EP - 11 TI - Decreto 2270 de 2012 ER - TY - RPRT AU - FEDEGAN PY - 2018 SP - 68 EP - 68 TI - Normas Fundamentales ER - TY - GEN AB - A Dios por darme la vida y la oportunidad de salir adelante y poder culminar mi carrera profesional. Dedico este triunfo a mis padres por darme el cariño y el apoyo incondicional en cada una de las decisiones que he tomado en mi vida, les agradezco por haberme inculcado buenos sentimientos, hábitos y valores, lo que me permitió salir adelante en los momentos más difíciles. A la doctora Yenni Milena Cruz por el apoyo y conocimiento brindado en la secretaria de hacienda que hizo de esta experiencia una de las más gratificantes e importantes, durante el tiempo que desarrolle mi práctica profesional. A mis maestros que me acompañaron en este largo camino de aprendizaje, de cada uno de ellos me llevo algo valioso para mi vida personal y profesional. Sebastián Ardila Díaz 3 Esta obra está bajo una Licencia Creative Commons Atribución-NoComercial-SinDerivadas 4.0 Internacional. CONTENIDO AU - Diaz, Sebastian Ardila AU - Metodológico, Asesor AU - Rodriguez, Mario Samuel PY - 2014 SP - 44 EP - 44 TI - Analisis del impuesto de deguello de ganado en el departamento del tolima de los años 2014-2018 ER - TY - JOUR AU - García Galindo, Germán PY - 2009 SP - 157 EP - 178 TI - Fortalecimiento de las Finanzas Públicas Territoriales T2 - Revista Escuela de Administración de Negocios UR - http://www.redalyc.org/articulo.oa?id=20612980009 VL - 65 ER - TY - GEN AU - INVIMA PY - 2019 SP - 29 EP - 29 TI - Implementacion del decreto 1500 de 2007 ER - TY - GEN AB - Sobre descentralización administrativa AU - Asamblea Nacional Constituyente y Legislativa de Colombia PY - 1909 SP - 8 EP - 11 TI - Ley 8 de 1909 UR - https://www.arauca.gov.co/gobernacion/normatividad/leyes/1114-ley-08-de-1909/file ER - TY - GEN AU - ICA PY - 2018 SP - 1 EP - 1 TI - Mapa de predios Bovinos Colombia 2018 ER - TY - JOUR AB - Resumen A través del siguiente trabajo se presentan los conceptos fundamentales, desde el punto de vista económico y de la metodología econométrica, que rodean la estimación de funciones de demanda. Para ello se aplica la metodología econométrica: 1. especificación del modelo; 2. estimación del modelo; 3. evaluación de los parámetros estimados, y 4. evaluación de la predicción, que dará como resultado un modelo aproximado de la función de demanda de carne de res en Colombia. El uso de la teoría de la demanda facilita evaluar la conducta de los consumidores y su reacción ante los cambios en el precio del bien, en su ingreso, en los precios de otros bienes relacionados por sus consumos (complementarios o sustitutos). Los resultados obtenidos permitirán explicar el procedimiento para validar un modelo estimado, desde el punto de vista econométrico (matemático, estadístico y económico). Abstract This paper examines the main concepts from the economic point of view and considering the econometric methodology which is based on the estimation of demand functions. In order to do that, the methodology applied considers 1) the specification of the model; 2) estimation of the model; 3) evaluation of considered parameters; and 4) evaluation of prediction. As a result, it will give an approximated model of demand function of cattle meat in Colombia. The use of this theory facilitates to evaluate the consumers behaviors and aptitude to the prices changes of this good, market introduction, and prices of relates goods (complementary or substitutes). The results will allow to explain the procedures to validate a model from the econometric point of view (in mathematical, statistical and economic terms). K e y w o r d s : D e m a n d , E c o n o m e t r i c , R e g r e s s i o n , E l a s t i c i t y , F u n c t i o n Introducción Los progresos de la ciencia económica han producido un notable desarrollo de las técnicas econométricas y de su uso en el análisis económico. La econometría se ha convertido en una herramienta de aplicación generalizada para la toma de decisiones. Es por ello que se plantean aquí tres objetivos fundamentales con este trabajo: el primero es el de AU - Caraballo, Leonardo J IS - 2 PY - 2003 SP - 95 EP - 104 TI - ¿Cómo Estimar Una Funcion De Demanda? Caso: Demanda De Carne De Res En Colombia T2 - Geoenseñanza VL - 8 ER - TY - RPRT AU - Invima PY - 2018 SN - 2018007742 SP - 15 EP - 15 TI - Situación Actual Plantas De Beneficio De Bovinos Y Porcinos Como Resultado De Los Planes De Racionalización De Plantas De Beneficio UR - https://www.invima.gov.co/images/pdf/informate/Plantas_Beneficio/INFORMACION-PLANTAS-DE-BENEFICIO-DE-BOVINOS-Y-PORCINOS-PRPBA-31102018.pdf ER - TY - GEN AU - Alcaldia de Gambita PY - 1986 SP - 112 EP - 112 TI - Estatuto de rentas del municipio de gambita, santander ER - TY - GEN AU - gobernacion de meta PY - 2005 SN - 4450130006 SP - 1 EP - 4 TI - Impuesto al degüello de ganado mayor en el Departamento del Meta ER - TY - GEN AU - Gobernacion del cauca PY - 2018 SP - 1 EP - 4 TI - Impuesto al degüello de ganado mayor en el Departamento del Cauca ER - TY - JOUR AU - Barrera-Valencia, Hernando IS - 6 KW - análisis de KW - aproximación KW - autor KW - carnes KW - consumo de carne KW - demanda casi ideal KW - elasticidad KW - función de demanda en KW - lineal al sistema de KW - mercado cárnico en colombia KW - modelos econométricos KW - palabras clave descriptor PY - 2010 SP - 179 EP - 220 TI - La función de demanda observada de carnes en coLombia (2000-2007): anáLisis comparativo de resuLtados de varios modeLos econométricos T2 - Rev. maest. derecho econ VL - 6 ER - TY - CHAP AB - En general en 2016, la producción mundial de carne aumentó solo 1%, a 317 millones de toneladas (Mt), y el crecimiento en los continentes americano y europeo se compensó con la baja en la producción de China, en particular, pero también en Australia. Se trató del segundo menor aumento anual en la última década. Entre los diversos sectores, la producción de carne de aves de corral y de bovino se incrementó, en tanto que en la producción de carne de cerdo y la de ovino la baja fue evidente. Medidos por el índice de precios de la carne de la FAO, a principios de 2016 los precios se encontraban en niveles bajos, equivalentes a los observados por última vez a finales de 2009 y, si bien durante el transcurso del año tuvieron cierta recuperación, los precios anuales promedio son comparables con los niveles obtenidos en 2010, es decir, se ubican muy por debajo de los máximos recientes. El aumento de los precios ocurrió en todas las categorías de carnes, en particular la de ovino, cerdo y aves, y el aumento más moderado correspondió a la de bovino. Las ofertas limitadas de carne de cerdo en la Unión Europea y de ovino en Oceanía sostuvieron los precios de estos productos, en tanto que la firme demanda internacional, sobre todo de Asia, apuntaló los precios de la carne de aves de corral. Mientras tanto, la recuperación de la producción de carne de bovino en Estados Unidos redujo las necesidades de importación, lo cual contribuyó a que los precios internacionales de este producto aumentaran menos que los de otras categorías de carne. El comercio mundial de la carne se recuperó en 2016, al aumentar 5% a 30 Mt. Esto representa el regreso a los niveles de tendencia después de la baja de 2015. El comercio aumentó 9% en el caso de la carne de cerdo, 5% en la carne de aves de corral y 3% en la carne de bovino, en tanto que en la carne de ovino disminuyó 3%. En lo que se refiere a los países, China, en particular, aumentó sus importaciones de carne, junto con Chile, Corea, México, la Unión Europea, Filipinas, Sudáfrica y Emiratos Árabes Unidos. En cambio, el crecimiento de la producción interna redujo las importaciones realizadas por Estados Unidos y Canadá. Australia, la Federación de Rusia y Angola también importaron menos. El aumento en las exportaciones mundiales de productos cárnicos fue encabezado por Brasil y la Unión Europea, seguidos por Estados Unidos, y las ventas también aumentaron en Argentina, Canadá, México, Nueva Zelanda, Paraguay y Tailandia. Por otra parte, las exportaciones de Australia, China, India, Sudáfrica y Turquía disminuyeron. Aspectos relevantes de la proyección Las perspectivas del mercado de la carne se mantienen relativamente favorables para los productores. Los precios de los cereales forrajeros disminuyeron y, bajo el supuesto de un clima estable, se estima que permanecerán bajos durante el periodo de proyección. Esto aportará estabilidad a un sector que había funcionado en un entorno con costos de forrajes particularmente altos y volátiles durante periodos prolongados en toda la década pasada. Esto se aplica en particular a regiones como el continente americano, Australia y Europa, donde los cereales forrajeros se utilizan con mayor intensidad en la producción de carne. Se prevé que la producción mundial de carne sea 13% mayor en 2026 que en el periodo base (2014-2016). Ello en comparación con un aumento de casi 20% en la década anterior. Se estima que los países en desarrollo representen la gran mayoría del aumento total, dado el uso más intensivo de los forrajes en el proceso de producción. La carne de aves de corral es el principal impulsor del crecimiento de la producción total de carne, debido a la mayor AU - OCDE-FAO DO - 10.1787/agr-data-en PY - 2017 SP - 15 EP - 15 TI - Situación del mercado de la Carne a nivel Mundial T2 - Perspectivas agricolas 2017-2026 UR - http://dx.doi.org/10.1787/ ER - TY - GEN AU - Ministerio de la proteccion social PY - 2007 SP - 41 EP - 41 TI - Decreto 1500 DE 2007 ER - TY - GEN AU - Pérez Vasquez, Manuel Antonio PY - 2017 SP - 147 EP - 147 TI - Analisis de los canales de comercializacion y condiciones de trazabilidad de la carne fresca en el departamento de sucre, para una estrategia hacia el mercado canadiense ER - TY - GEN AU - sabermassermas.com PY - 2019 TI - ¿Qué es el IVA? T2 - sabermassermas.com UR - https://www.sabermassermas.com/que-es-el-iva/ ER - TY - GEN AB - Decreto 2278 de 1982 Los datos publicados tienen propósitos exclusivamente informativos. El Departamento Administrativo de la Función Pública no se hace responsable de la vigencia de la presente norma. Nos encontramos en un proceso permanente de actualización de los contenidos. DECRETO 2278 DE 1982 (Agosto 02) Derogado por el art. 98, Decreto Nacional 1500 de 2007 "Por el cual se reglamenta parcialmente el Título V de la Ley 09 de 1979 en cuanto al sacrificio de animales de abasto público o para consumo humano y el procesamiento, transporte y comercialización de su carne." EL PRESIDENTE DE LA REPÚBLICA DE COLOMBIA En uso de las atribuciones que le confiere el ordinal tercero del Articulo 120 de la Constitución Política y la Ley 09 de 1979 DECRETA: TÍTULO PRELIMINAR DISPOSICIONES GENERALES Y DEFINICIONES ARTÍCULO 1°. El sacrificio de animales de abasto público o para consumo humano y la carne en canal que se procese, transporte, comercialice o consuma en el territorio nacional, así como la que se destine para exportación, se someterán a las reglamentaciones del presente decreto y a las disposiciones complementarias que, en desarrollo del mismo o con fundamento en la Ley, dicte el Ministerio de Salud. ARTÍCULO 2°. La máxima Autoridad Sanitaria en los establecimientos en donde se sacrifique, procese y transporte animales de abasto público o para consumo humano, será el Médico Veterinario Oficial cuya presencia será obligatoria en los Mataderos Clases 1 y 11. En los mataderos Clase III esta autoridad será ejercida por el Promotor de Saneamiento, bajo la supervisión del Médico Veterinario Oficial. ARTÍCULO 3º. La construcción, ampliación, remodelación o habilitación, de los mataderos de animales de consumo humano, así como su funcionamiento, estarán sujetos a las reglamentaciones contenidas en el presente Decreto y a las disposiciones complementarias que en desarrollo del mismo o con fundamento en la ley, dicte el Ministerio de Salud. PARÁGRAFO. Para los efectos del presente artículo, cuando sea del caso, deberán tenerse en cuenta las regulaciones que se dicten para la coordinación de programas integrados entre el Ministerio de Salud y otros organismos. ARTÍCULO 4°. Denominase MATADERO Iodo establecimiento dotado con Instalaciones necesarias para el sacrificio de animales de abasto público o para consumo humano, así como para tareas complementarias de elaboración o Industrialización cuando sea del caso, que de conformidad con el presente decreto haya obtenido Licencia Sanitaria de Funcionamiento para efectuar dichas actividades. ARTÍCULO 5°. Denominase ANIMALES DE ABASTO PUBLICO o para CONSUMO HUMANO, los bovinos, porcinos ovinos, caprinos, aves conejos, animales producto de la caza y otras especies que el Ministerio de Salud declare aptas para dichos fines. PARÁGRAFO. Para efectos de exportación, los équidos se consideran animales de consumo humano. Departamento Administrativo de la Función Pública Decreto 2278 de 1982 2 EVA-Gestor Normativo ARTÍCULO 6°. Para los efectos del presente decreto entiéndese por CARNE PARA CONSUMO HUMANO las partes comestibles de todo animal de abasto público sacrificado en un matadero que llene los requisitos señalados en el presente decreto. PARÁGRAFO. Por extensión, para los efectos del presente artículo, se consideran como carne las vísceras y otras partes comestibles de los animales de consumo humano. ARTÍCULO 7°. Entiéndase por CARNE EN CANAL el cuerpo de cualquier animal de abasto público o para consumo humano, después de haber sido sacrificado y eviscerado. En materia de aves, se denomina CANAL el cuerpo entero de un ave después de insensibilizado, sangrado, desplumado y eviscerado. ARTÍCULO 8°. Entiéndase por MENUDENCIAS de las aves el hígado, sin la vesícula biliar, el corazón la molleja sin la membrana mucosa y su contenido, el bazo, las patas sin uñas, el pescuezo sin esófago ni tráquea y la cabeza sin pico. AU - Presidencia de la republica PY - 1982 SP - 59 EP - 59 TI - Decreto 2278 de 1982 ER - TY - GEN AU - la republica PY - 2016 TI - Así funciona el sistema tributario de Colombia y la Dian T2 - Diario la Republica UR - https://www.larepublica.co/economia/asi-funciona-el-sistema-tributario-de-colombia-y-la-dian-2346891 ER - TY - RPRT AB - Febrero de 2005 (Resumen) En este documento pasamos revista a la estructura tributaria colombiana. Primero, en el contexto de lo que ocurre en América Latina y, segundo, evaluamos las tendencias históricas en materia de impuestos nacionales-territoriales, directos-indirectos y, en particular, la relación impo-renta-patrimonio. Nuestro mensaje básico es que solo a través de una mayor transparencia y equidad tributaria será posible equilibrar la frágil estructura de recaudos que se tiene hoy día. El actual sistema tributario es una amalgama insostenible de altas tasas de impo-renta, con múltiples exenciones, y descansa sobre una legislación temporal. Todo esto obligará al Estado colombiano a adoptar soluciones de fondo durante los años 2005-2006, que necesariamente implicarán una ampliación y elevación de la tasa de IVA, tal como ocurre en las "social-democracias" mas avanzadas. De no lograrse un mejor balance, es indudable que la estructura productiva se verá negativamente afectada, con grave riesgo para nuestra penetración de los mercados internacionales, ahora que se avecina la firma de acuerdos comerciales tipo TLC-ALCA. Clasificación JEL: Tributación y Recaudos (H20); Latinoamérica (N26). * / Miembro de la Junta Directiva Banco de la República. Las opiniones aquí expresadas son exclusiva responsabilidad del autor. AU - Clavijo, Sergio PY - 2005 SP - 29 EP - 29 TI - Tributación, Equidad y eficiencia en Ciolombia: Guía para Salir de un Sistema Tributario Amalgamado ER - TY - RPRT AB - Los desafíos de las políticas públicas en el marco de la Agenda 2030 2018 AU - Comisión Económica para América Latina y el Caribe CY - Santiago PY - 2018 SP - 137 EP - 137 TI - Panorama Fiscal de América Latina y el Caribe UR - www.cepal.org/es/suscripciones ER - TY - GEN AU - Kalmanovitz, Salomón PY - 2016 TI - Representación sin tributación T2 - Diario el Espectador UR - https://www.elespectador.com/opinion/representacion-sin-tributacion ER - TY - GEN AB - Ley 75 de 1986 Los datos publicados tienen propósitos exclusivamente informativos. El Departamento Administrativo de la Función Pública no se hace responsable de la vigencia de la presente norma. Nos encontramos en un proceso permanente de actualización de los contenidos. LEY 75 DE 1986 (Diciembre 23) "Por la cual se expiden normas en materia tributaria, de catastro, de fortalecimiento y democratización del mercado de capitales, se conceden unas facultades extraordinarias y se dictan otras disposiciones." CAPÍTULO I TARIFAS Y RETENCIONES. ARTÍCULO 1º. Fijase en un treinta por ciento (30%) la tarifa única sobre la renta gravable y las ganancias ocasionales de las sociedades anónimas, de las sociedades limitadas, y de los demás entes asimilados a unas y otras de conformidad con las normas pertinentes. La misma tarifa se aplicará a la renta gravable y las ganancias ocasionales de las sociedades extranjeras de cualquier naturaleza y a cualesquiera otras entidades extranjeras. PARÁGRAFO 1º. Transitorio. Para los años gravables 1986, 1987 y 1988, la tarifa única sobre la renta gravable y las ganancias ocasionales de las sociedades anónimas y sus asimiladas será del treinta y tres por ciento (33%), treinta y dos por ciento (32%) y treinta y uno (31%), respectivamente. Para los años gravables 1989 y siguientes, esta tarifa se regirá por lo previsto en el inciso primero de este artículo. PARÁGRAFO 2º. Transitorio. Para los efectos del numeral 1º del artículo 22 de la presente Ley, el Gobierno fijará, con base en los porcentajes de que trata el parágrafo anterior y para los años objeto del mismo, la fórmula matemática que debe utilizarse para determinar el monto de las utilidades susceptibles de ser distribuidas a título de ingreso no constitutivo de renta ni de ganancia ocasional. PARÁGRAFO 3º. Transitorio. Por el año gravable de 1986, para tener derecho a la reducción de la tarifa impositiva prevista en este artículo, las sociedades anónimas nacionales y sus asimiladas deberán destinar el 100% del menor egreso causado en 1986 en virtud de la disminución de la tarifa, a: 1). Aumentar el capital suscrito y pagado de la empresa. 2). Constituir una reserva no distribuible, para expansión del negocio. En este caso la sociedad deberá demostrar durante 1987 a la Superintendencia de Sociedades o Bancaria, según el caso, la expansión alcanzada con el uso de los recursos reservados. 3). Adquirir títulos señalados por el Gobierno Nacional. 4). La que resulte de combinar las alternativas anteriores. ARTÍCULO 2º. La tarifa única sobre la renta gravable y las ganancias ocasionales, de fuente nacional, de las personas naturales extranjeras sin residencia en el país, es del 30%. La misma tarifa se aplica a las sucesiones de causantes extranjeros sin residencia en el país. ARTÍCULO 3º. La tarifa del impuesto sobre la renta correspondiente a dividendos percibidos por sociedades u otras entidades extranjeras, por personas naturales extranjeras sin residencia en Colombia y por sucesiones ilíquidas de causantes extranjeros que no eran residentes en Colombia, es del 30%. Este impuesto será retenido en la fuente sobre el valor bruto de los pagos o abonos en cuenta por concepto de dividendos. ARTÍCULO 4º. El impuesto correspondiente a la renta gravable y a las ganancias ocasionales, de las personas naturales colombianas, de las sucesiones de causantes colombianos, de las personas naturales extranjeras residentes en el país, de las sucesiones de causantes extranjeros residentes en el país y de los bienes destinados a fines especiales, en virtud de donaciones o asignaciones modales, es el determinado en la tabla que contiene el presente artículo. Para cada uno de estos contribuyentes, el impuesto sobre la renta es el indicado frente al intervalo al cual corresponda su renta gravable; el impuesto de ganancias ocasionales es el indicado frente al intervalo al cual corresponda su ganancia ocasional. AU - Senado de la republica PY - 1986 SP - 32 EP - 32 TI - Ley 75 de 1986 ER - TY - RPRT AU - secretaria distrital de salud CY - Bogota PY - 2010 SP - 11 EP - 11 TI - Plantas de sacrificio de bovinos y porcinos ER - TY - GEN AU - Ministerio de Salud DO - 10.7705/biomedica.v32i4.1526 PY - 1993 TI - Resolucion 8430 de 1993 ER - TY - RPRT AU - Contraloría general del Choco CY - Quibdo PY - 2017 SP - 60 EP - 60 TI - informe de auditoria especial, Gobernacion departamento del Choco ER - TY - GEN AU - Instituto Colombiano Agropecuario PY - 2020 TI - Instituto Colombiano Agropecuario - ICA UR - https://www.ica.gov.co/areas/pecuaria/servicios/epidemiologia-veterinaria/censos-2016/censo-2018 ER - TY - GEN AU - Congreso de la Republica PY - 1986 SP - 32 EP - 32 TI - Decreto 1222 de 1986 UR - https://www.funcionpublica.gov.co/eva/gestornormativo/norma.php?i=6100 ER - TY - GEN AU - Congreso Nacional de la República PY - 1986 SP - 36 EP - 36 TI - Ley 1333 de 1986 ER - TY - JOUR AB - The aim of this study was to determine the incidence of incidental prostate cancer and its clinical significance among patients who underwent transurethral prostate resection or transvesical adenomectomy for benign prostate hyperplasia at the Department of Urology in Sestre milosrdnice University Hospital Center from January 1997 to December 2017. A total of 277/4,372 (6.34%) patients from our cohort were diagnosed with incidental prostate cancer (mean age 74.5 years). Due to incomplete data, 12 patents were excluded from further analysis. 44.91% (119/265 patents) of our cohort were stage T1a and 55.09% (146/265) were stage T1b. Clinically significant prostate cancer was found in 168/265 patients (63.40%). When divided into two groups, Gleason score ≤6 (mean age 73.58 years) and Gleason score ≥7 (mean age 75.77 years), the results showed that Gleason score ≥7 patients were significantly older (p=0.0104) and that the tumor extent among patients in this group (mean = 34.58%) was higher than that in Gleason score ≤6 group (mean = 11.11%) (p=0.0169). More than a half of patients in our cohort had T1b stage prostate cancer. We found that 63.4% of carcinomas were clinically significant, with 52/265 (19,62%) patients affected by ISUP grade 4 and 5 cancers. Based on our research, we cannot give any recommendations regarding incidental prostate cancer treatment due to lacking preoperative (PSA, DRE) and follow-up data. AU - Pirša, Matea AU - Pezelj, Ivan AU - Knežević, Matej AU - Spajić, Borislav AU - Tomašković, Igor AU - Reljić, Ante AU - Ružić, Boris DA - 2018/10// DO - 10.20471/acc.2018.57.s1.11 IS - Suppl 1 KW - BPH KW - Benign prostate hyperplasia KW - Incidental prostate cancer KW - TURP PB - NLM (Medline) PY - 2018 SP - 71 EP - 76 TI - Incidental Prostate Cancer in Patients Treated for Benign Prostate Hyperplasia in the Period of 21 Years T2 - Acta clinica Croatica VL - 57 ER - TY - JOUR AB - Resumen.-OBJETIVO: El hallazgo de adenocarcino-ma prostático en piezas quirúrgicas sin diagnóstico pre-vio de tumor se presenta en 4 a 15% de los pacientes. En algunos, existe sospecha previa, en otros, el hallaz-go es "incidental". Presentamos 7 casos de cáncer de próstata detectados en 100 pacientes a quienes se les realizó resección transuretral (RTU) bipolar de próstata debido a indicaciones quirúrgicas habituales. El objeti-vo de este trabajo es describir las características de los pacientes en quienes se encontró cáncer en la resección transuretral y su evolución postoperatoria, analizar la RTU como herramienta diagnóstica y evaluar las opcio-nes de tratamiento. MÉTODO: Entre junio de 2007 y agosto de 2009, se realizaron en FUCDIM 100 RTU bipolares de próstata en pacientes con patología obstructiva. En 7 se detectó adenocarcinoma de próstata. A ningún paciente se le realizó RTU solamente por elevación del antígeno pros-tático específico (PSA). RESULTADOS: El promedio de PSA preoperatorio fue 7,6 ng/ml (r= 0,72-27 ng/ml), 39% de los pacientes tenían PSA <4 ng/ml; 33 (40%) pacientes tenían biop-sias previas y 36% de ellos 2 o más biopsias. La tasa global de detección de cáncer de próstata fue de 7%, 3 fueron hallazgos "incidentales" (PSA bajo y tumor de bajo riesgo), 3 con PSA elevado y varias biopsias previas negativas y 1 con PSA bajo y tumor agresivo (Gleason 4+3). CONCLUSIONES: Los pacientes con cáncer de prós-tata como hallazgo incidental durante la RTU constitu-yen un grupo heterogéneo. En pacientes con síntomas obstructivos, PSA elevado y biopsias negativas, la RTU es a la vez diagnóstica y terapéutica. Las alternativas terapéuticas ante el diagnóstico de CaP tras la RTU son variadas y se debe tener en cuenta el grado y esta-dío del tumor, edad, expectativa de vida y voluntad del paciente. La RTU bipolar permite plantear, en pa-cientes seleccionados, la posibilidad de ofrecer "active surveillance"(en este grupo es muy útil el PSADT) y de no encontrarse el tumor, facilita el seguimiento de estos pacientes. El tratamiento activo (cirugía o radioterapia) está indicado en pacientes T1a con expectativa de vida mayor a 10 años, y en la mayoría de pacientes T1b. AU - Dellavedova, Tristán AU - Ponzano, Rolando AU - Racca, Laura AU - Minuzzi, Federico AU - Domínguez, Mariana IS - 10 PY - 2010 SP - 855 EP - 861 TI - Cancer de prostata como hallazgo en reseccion transuretral T2 - Arch. Esp. Urol. VL - 63 ER - TY - JOUR AB - Objetivo. Estudiar las características de los pacientes con cáncer de próstata incidental. Material y métodos. La proporción de cáncer de próstata diagnosticado accidentalmente se investigó en pacientes sometidos a resección transuretral de próstata (RTUP) en nuestra clínica durante un período de 5 años. El cáncer de próstata incidental "verdadero" se definió como los casos en que el examen rectal digital preoperatorio (DRE) y el valor del antígeno prostático específico (PSA) eran normales. Los pacientes con malignidad conocida de la próstata fueron excluidos, junto con aquellos con PSA? / 4 ng / ml y / o un DRE positivo. Las características de estos pacientes se compararon con las de los pacientes con hiperplasia prostática benigna y el grupo como todo. Resultados De los 786 pacientes operados entre 1999 y 2003, 34 (4,3%) tenían un informe de patología positivo para el cáncer de próstata incidental "verdadero". Se observó una mayor frecuencia de tumores mal diferenciados (32,3%). De los 34 pacientes, 17 estaban en estadio T1a y 17 T1b; 11 pacientes tuvieron una suma de Gleason de 7? / 10, todos ellos en el grupo T1b. En el T1b grupo la edad media fue de 74 años, el nivel medio de PSA 2.9 ng / ml y el peso medio de tejido resecado 11.1 g. Los valores correspondientes en los pacientes con T1a fueron 70,1 años, 3,32 ng / ml y 18,2 g. Conclusiones En comparación con estudios anteriores, notamos una baja incidencia de carcinoma de próstata incidental "verdadero", pero una alta proporción de tumores mal diferenciados (todos en estadio T1b). En comparación con el grupo en general, los pacientes con cáncer de próstata incidental eran mayores y tenían volúmenes más pequeños de próstata y zona de transición. Se necesita más investigación para identificar los parámetros que pueden ayudar en la identificación temprana del cáncer de próstata incidental, ya que los pacientes pueden beneficiarse del tratamiento curativo. Llave AU - Argyropoulos, Athanasios AU - Doumas, Konstantinos AU - Farmakis, Antonios AU - Aristas, Odysseas AU - Kontogeorgos, Georgios AU - Lykourinas, Michael DO - 10.1080/00365590510031200 IS - 4 KW - Epidemiology KW - Incidental prostate cancer KW - Latent KW - Pathological factors KW - Significant tumors PB - Taylor & Francis PY - 2005 SP - 289 EP - 293 TI - Characteristics of patients with stage T1b incidental prostate cancer T2 - Scandinavian Journal of Urology and Nephrology VL - 39 ER - TY - JOUR AB - El propósito de este estudio es evaluar la probabilidad de detectar cáncer en estadio T1a y T1b en muestras de prostatectomía transuretral durante la era del PSA. Se compararon las cohortes de resección transuretral de próstata (RTUP) en la era anterior al PSA (1986-1987) y la era del PSA (1994-2000), excluyendo pacientes con PCa conocida. Un total de 228 hombres sin antecedentes conocidos de cáncer de próstata se sometieron a RTUP durante el período de tiempo anterior a la PSA y 501 se sometieron al procedimiento durante el período de la era de PSA. La neoplasia maligna diagnosticada en el momento de la RTUP disminuyó del 14,9 al 5,2% de los pacientes en las épocas pre-PSA y PSA, respectivamente. La etapa T1a disminuyó de 4.4 a 2.4% y la etapa T1b disminuyó de 10.5 a 2.8% de los pacientes en las eras anteriores al PSA y PSA, respectivamente (Po0.001, prueba exacta de Fisher). El cáncer de próstata recientemente identificado durante la RTUP ha disminuido significativamente en la era del cribado del PSA en nuestra población de estudio, y la caída más significativa se encuentra en la etapa clínicamente significativa T1b. La disminución en las tasas de RTUP reduce la incidencia general de cáncer T1a / b, pero no puede explicar el menor riesgo de detectar cáncer previamente no sospechado en el momento de cualquier RTUP. La identificación de muchos hombres con cáncer de próstata oculto antes de la RTUP a través de la detección y detección temprana es la causa más probable de este hallazgo. Estos datos sugieren que los hombres que estén considerando el tratamiento quirúrgico o médico de la hiperplasia prostática benigna pueden ser informados de que debe ser poco frecuente que los hombres evaluados adecuadamente para el cáncer de próstata alberguen malignidad no detectada clínicamente significativa AU - Jones, J S AU - Follis, H W AU - Johnson, J R DO - 10.1038/pcan.2008.14 PY - 2009 SP - 57 EP - 60 TI - Probability of finding T1a and T1b (Incidental) prostate cancer during TURP has decreased in the PSA era T2 - Prostate Cancer and Prostatic Diseases UR - www.nature.com/pcan VL - 12 ER - TY - JOUR AB - Objectives. To identify rates of incidentally detected prostate cancer in patients undergoing surgical management of benign prostatic hyperplasia (BPH). Materials and Methods. A retrospective review was performed on all transurethral resections of the prostate (TURP) regardless of technique from 2006 to 2011 at a single tertiary care institution. 793 men (ages 45-90) were identified by pathology specimen. Those with a known diagnosis of prostate cancer prior to TURP were excluded (í µí±› = 22) from the analysis. Results. 760 patients had benign pathology; eleven (1.4%) patients were found to have prostate cancer. Grade of disease ranged from Gleason 3 + 3 = 6 to Gleason 3 + 4 = 7. Nine patients had cT1a disease and two had cT1b disease. Seven patients were managed by active surveillance with no further events, one patient underwent radiation, and three patients underwent radical prostatectomy. Conclusions. Our series demonstrates that 1.4% of patients were found to have prostate cancer, of these 0.5% required treatment. Given the low incidental prostate cancer detection rate, the value of pathologic review of TURP specimens may be limited depending on the patient population. AU - Otto, Brandon AU - Barbieri, Christopher AU - Lee, Richard AU - Te, Alexis E AU - Kaplan, Steven A AU - Robinson, Brian AU - Chughtai, Bilal DO - 10.1155/2014/627290 PY - 2014 TI - Incidental Prostate Cancer in Transurethral Resection of the Prostate Specimens in the Modern Era T2 - Advances in Urology UR - http://dx.doi.org/10.1155/2014/627290 ER - TY - JOUR AU - Elías, Enrique AU - Marco Enriquez, E 1 AU - Nova, Aldo AU - Garrido, Cristian AU - Caiseo, Felipe AU - Arias, Marco AU - Alarcon, Luis AU - Araneda, Juan AU - Llompart, Matías IS - 2 PY - 2013 SP - 57 EP - 60 TI - Characterization of incidental prostate cancer T2 - Revista chilen ade urologia VL - 78 ER - TY - JOUR AU - Pardo, Constanza AU - Cendales, Ricardo IS - 1 PY - 2018 SP - 16 EP - 22 TI - Estimaciones de incidencia y mortalidad para los principales cinco tipos de cáncer en Colombia, 2007-2011 T2 - Colomb Med VL - 49 ER - TY - JOUR AB - Introducción: la resección transuretral de la próstata (RTUP) se realiza comúnmente como el tratamiento quirúrgico de los síntomas del tracto urinario inferior debido a una enfermedad clínicamente benigna. Sin embargo, el cáncer de próstata no se diagnostica poco después de dicho procedimiento. Por lo tanto, determinamos en un estudio retrospectivo la incidencia y los factores que podrían predecir la detección del cáncer de próstata después de la RTUP. Pacientes y métodos: entre junio de 2005 y junio de 2007, un total de 476 hombres se sometieron a RTUP en nuestro departamento. De estos, se creía que 411 hombres (86%) tenían enfermedad benigna y se incluyeron en el estudio. Se realizaron análisis de regresión logística univariada y multivariada utilizando la edad, el antígeno prostático específico (PSA) en suero, el estado de retención urinaria, el peso de resección de la próstata, FBC y U&E para determinar si se podía predecir el cáncer de próstata. Resultados: Un total de 47 hombres (11.4%) fueron diagnosticados con cáncer de próstata [24/47 con pT1a (51%) y 23/47 con pT1b (49%)]. Además, los puntajes de Gleason oscilaron entre 5 y 9. Los análisis de regresión logística univariada revelaron que solo la edad (media: 76 años, rango: 54-90 vs. media: 71 años, rango: 49-91 para el cáncer de próstata y no casos de cáncer, respectivamente) y PSA sérico (media: 14,9 ng / ml, rango: 0,4–78,0 frente a media: 7,4 ng / ml, rango: 0,2–90,0 para casos de cáncer de próstata y casos no cancerosos, respectivamente) capaz de distinguir entre cáncer y casos no cancerosos. Además, utilizando la regresión logística multivariada, la edad y el PSA en suero también fueron las únicas variables que separaron los dos grupos con un ROC-AUC del 70%. Conclusiones: Nuestro estudio retrospectivo ha demostrado que inesperadamente un porcentaje sustancial de hombres tiene cáncer de próstata después de la RTUP. Además, la edad y el PSA en suero fueron predictores independientes de aquellos que probablemente tengan cáncer de próstata AU - Bright, Elizabeth A. AU - Manuel, Clare AU - Goddard, Jonathan C. AU - Khan, Masood A. DA - 2009/9// DO - 10.1159/000230019 IS - 2 KW - Prostate KW - Prostate cancer KW - Prostate-specific antigen KW - Transurethral resection of the prostate PB - Karger Publishers PY - 2009 SP - 171 EP - 174 TI - Incidence and Factors Predicting the Detection of Prostate Cancer after Transurethral Resection of the Prostate for Clinically Benign Disease T2 - Urologia Internationalis UR - https://www.karger.com/Article/FullText/230019 VL - 83 ER - TY - JOUR AB - Introducción: el cáncer de próstata se ha encontrado incidentalmente en la resección transuretral de las muestras de próstata (RTUP) sin diagnóstico previo en 5% a 13% de los pacientes. Evaluamos si el cáncer de próstata incidental (estadios T1a y T1b) podría predecirse preoperatoriamente. Métodos: la RTUP se realizó en 307 pacientes entre 2006 y 2011. Se evaluó la edad del paciente, el nivel de antígeno prostático específico (PSA), el volumen total de la próstata, el volumen de la zona de transición, la densidad del PSA, el historial de biopsia con aguja y el diagnóstico patológico de la muestra de RTUP. Analizamos la asociación entre estos parámetros y la detección del cáncer de próstata. Resultados: se encontró cáncer de próstata incidental en 31 pacientes (10.1%), y 13 casos (4.2%) tenían cáncer con T1b y / o Gleason ≥7. El análisis multivariado demostró que la edad ≥75 años (odds ratio [OR] 2.58, p = 0.022), el volumen de la próstata ≤50 cc (OR 4.11, p <0.001) y la ausencia de biopsia preoperatoria con aguja a pesar del PSA ≥4 ng / mL ( O 2,65, p = 0,046) fueron factores de riesgo independientes. En pacientes que tenían 2 o 3 de estos factores de riesgo, se observaron cáncer de próstata incidental y cáncer con T1b y / o Gleason ≥7 en casos del 25% al ​​50% y del 16% al 25%, respectivamente. Conclusiones: la edad avanzada del paciente, el pequeño volumen de la próstata y la ausencia de biopsia con aguja previa (a pesar de un alto nivel de PSA) pueden ser factores de riesgo independientes para detectar el cáncer de próstata incidental, aunque aunque se justifica la validación externa para confirmar nuestros resultados. AU - Sakamoto, Hirofumi AU - Matsumoto, Kazuhiro AU - Hayakawa, Nozomi AU - Maeda, Takahiro AU - Sato, Atsuko AU - Ninomiya, Akiharu AU - Mukai, Kiyoshi AU - Nakamura, So DA - 2014/11// DO - 10.5489/cuaj.1890 IS - 11-12 KW - Incidental KW - Prostate cancer KW - TURP PB - Canadian Medical Association PY - 2014 SP - e815 EP - e820 TI - Preoperative parameters to predict incidental (T1a and T1b) prostate cancer T2 - Journal of the Canadian Urological Association UR - https://cuaj.ca/index.php/journal/article/view/1890 VL - 8 ER - TY - JOUR AB - We investigated if an adequate histological diagnosis can be made from tissue after Thulium laser vapo-enucleation of the prostate (ThuVEP) and whether it is comparable to transurethral prostate resection (TURP) tissue findings in patients with symptomatic benign prostatic hyperplasia. We analyzed 350 ThuLEP and 100 matched TURP tissue specimens from patients who underwent one of the two procedures between January 2009 and June 2014. Thulium Laser Enucleation of Prostate (ThuVEP) was combined with mechanical morcellation of the resected lobe. Each histological specimen was reviewed by two pathologists. Preoperative prostate ultrasound volume, total serum prostatic specific antigen and postoperative tissue weight were evaluated. Microscopic histological diagnosis was assessed by standard histological techniques and immunohistochemical evaluation. Patients were comparable in terms of age and preoperative total serum prostate specific antigen. Incidental adenocarcinoma and high grade PIN of the prostate were diagnosed in a comparable percent of specimens in the 2 groups (2.5 % in the ThuVEP group versus 3 % in the TURP group). Tissue thermal artifacts induced by the Thulium laser are mostly due to coagulation as that of the conventional monopolar diathermy in TURP. Tissue quality was maintained in the ThuVEP histological specimens. Tissue maintain histological characteristics and proprieties without modification for successive immunoistochemical analysis. The pathologist ability to detect incidental prostate cancer and PIN was maintained even if there is a quoted of vaporized tissue. AU - Carmignani, Luca AU - Macchi, Alberto AU - Ratti, Dario AU - Finkelberg, Elisabetta AU - Casellato, Stefano AU - Bozzini, Giorgio AU - Maruccia, Serena AU - Marenghi, Carlo AU - Picozzi, Stefano DA - 2015/9// DO - 10.1007/s12253-015-9931-x IS - 4 KW - Benign prostatic hypertrophy KW - Laser KW - Prostate KW - Thulium KW - Transurethral PB - Kluwer Academic Publishers PY - 2015 SP - 1071 EP - 1075 TI - Are Histological Findings of Thulium Laser Vapo-Enucleation Versus Transurethral Resection of the Prostate Comparable? T2 - Pathology and Oncology Research VL - 21 ER - TY - JOUR AB - Background: Awareness about prostate cancer has increased in the community, and prostate cancer screening examinations, including prostate specific antigen (PSA) assays, are now widely available. Prior to the PSA era, up to 27% of prostate cancers were detected incidentally at the time of transurethral resection of prostate (TURP). After PSA testing became widely available, the incidence of incidentally detected carcinoma prostate in TURP specimens without prior diagnosis reduced to 5-13%. However, the incidence of incidentally detected carcinoma prostate has been reported to vary across the globe since various factors can influence the identification of this malignancy in TURP specimens. In this paper, we focus on rates of incidentally detected prostate cancer in TURP specimens in our hospital and correlate it with various parameters. Materials and Methods: This retrospective study of histopathological findings of biopsy specimens was conducted for patients undergoing TURP during a period of 5 years from April 2010. The inclusion criteria were patients diagnosed with benign prostatic hyperplasia (BPH) (digital rectal examination (DRE) not showing any abnormally hard areas and normal age adjusted PSA values). Patients with elevated PSA, abnormal DRE, documented urinary tract infection and proved adenocarcinoma prostate (CaP) were excluded from the study. The total weight of prostatectomy specimen, occurrence of carcinoma prostate in the chips, percentage of total tissue resected showing malignancy and Gleason's scores were recorded. Results: A total of 597 patients belonging to the inclusion criteria were studied. The incidence of occult CaP in the study group was 5.2 % (31/597). Out of these, 8 belonged to T1a and 23 belonged to T1b stages. The age group 70 - 79 years had the maximum incidence of occult CaP. It was observed that the clinical grading of prostate did not have a bearing on the incidence of occult CaP whereas the weight of resected specimen correlated with the incidence of CaP. The incidence of occult CaP was greater with low volume prostates (< 20 g). (P=0.15). Conclusions: The rate of incidentally detected adenocarcinoma prostate in patients undergoing TURP for clinically diagnosed BPH was found to be only 5.2 % in our study which is low when compared with similar studies done elsewhere. The age of the patient and weight of the resected specimen correlated with incidence of occult prostate cancer. The clinical grading of prostate by DRE however, demonstrated no correlation. AU - Varghese, Jophy AU - Kuruvilla, Priya Mariam AU - Mehta, Nisarg AU - Rathore, Ranjeet Singh AU - Babu, Manas AU - Bansal, Devesh AU - Pillai, Biju AU - Sam, Mohan P. AU - Krishnamorthy, H. DO - 10.7314/APJCP.2016.17.4.2255 IS - 4 KW - Incidental prostate cancer KW - Prostate specific antigen (PSA) KW - Transurethral resection of prostate (TURP) PY - 2016 SP - 2255 EP - 2258 TI - Incidentally detected adenocarcinoma prostate in transurethral resection of prostate specimens: A hospital based study from India T2 - Asian Pacific Journal of Cancer Prevention VL - 17 ER - TY - JOUR AB - Objectives. To evaluate retrospectively the effectiveness of transurethral resection of the prostate (TURP) in diagnosing prostate cancer in patients with obstructive voiding symptoms and a history of negative transrectal prostate biopsy but elevated prostate-specific antigen (PSA) and/or abnormal digital rectal examination (DRE). Methods. In 1189 consecutive patients undergoing TURP or open prostatectomy between 1994 and 2000 for obstructive voiding symptoms, we identified 445 patients (37.4%) with at least one previous set of transrectal prostate biopsies because of an elevated PSA level and/or abnormal DRE findings. The probability to detect prostate cancer by TURP (n = 423; 95%) or open surgery (n = 22; 5%) was investigated overall, as well as related to patient age, PSA level, DRE findings, number of previous biopsies, time from biopsy to surgery, and weight of resected tissue. Results. The mean number of preoperative negative biopsies per patient was 1.6 (range 1 to 8). The mean patient age was 69 years (range 48 to 89). The median PSA level and resection weight was 8.64 ng/mL and 32 g, respectively. Ninety-seven patients (21.8%) had abnormal DRE findings. Overall, prostate cancer was detected in 35 patients (7.9%). The cancer incidence was 5.5% (19 of 348) in patients with a normal DRE compared with 16.5% (16 of 97) in patients with an abnormal DRE (P <0.001; Fisher's exact test). The cancer rate was also related to age; other subgroups showed no statistically significant differences regarding cancer incidence. Conclusions. In patients with previously negative biopsies, the diagnostic yield of TURP is low. Therefore, TURP for diagnostic purposes only cannot be recommended. However, in patients with an abnormal DRE and obstructive symptoms, surgery should be preferred over alternative treatment options. © 2003 Elsevier Inc. AU - Zigeuner, Richard AU - Schips, Luigi AU - Lipsky, Katja AU - Auprich, Marko AU - Salfellner, Michael AU - Rehak, Peter AU - Pummer, Karl AU - Hubmer, Gerhart DO - 10.1016/S0090-4295(03)00663-0 IS - 5 PB - Elsevier Inc. PY - 2003 SP - 883 EP - 887 TI - Detection of prostate cancer by TURP or open surgery in patients with previously negative transrectal prostate biopsies T2 - Urology VL - 62 ER - TY - JOUR AU - Yaspe, Edgardo AU - Campo, Piedad del Carmen AU - Polo, José Fernando KW - Hiperplasia Prostática KW - Humanos KW - Neoplasia Prostática Intraepitelial KW - Neoplasias da Próstata KW - Procedimentos Cirúrgicos Urológicos Masculinos KW - Ressecção Transuretral da Próstata PY - 2009 SP - 70 EP - 75 TI - Adenocarcinoma incidental de próstata en resección transuretral por causa benigna: Hospital de San José, julio 2006 a marzo 2008 T2 - Repert. med. cir ER - TY - JOUR AU - Acuña, E AU - Morales, C AU - Silva, M AU - Olivares, R AU - Vicherat, C AU - Sarras, E AU - San Martín, R AU - Díaz-Valdés, R AU - Valdivia, P KW - Adulto KW - Antígeno Prostático Específico KW - Estatísticas Hospitalares KW - Estudos Retrospectivos KW - Hiperplasia Prostática KW - Humanos KW - Idade KW - Masculino KW - Pessoa de Meia KW - Prostatectomia KW - Reoperação KW - Tempo de Internação PY - 2003 SP - 193 EP - 198 TI - Manejo quirúrgico transvesical de la hiperplasia prostática benigna: Servicio de Urología Hospital Barros Luco Trudeau T2 - Rev. chil. urol ER - TY - GEN TI - Uroweb - European Association of Urology (EAU) UR - https://uroweb.org/ ER - TY - GEN TI - Global Cancer Observatory UR - https://gco.iarc.fr/ ER - TY - JOUR AU - Bolaños Morera, Pamela AU - Chacón Araya, Carolina IS - 1 PY - 2017 TI - Escala patologica de Gleason oara el cancer de prostata y sus modificaciones T2 - Medicina Legal de Costa Rica VL - 34 ER - TY - JOUR AB - La resección transuretral de próstata es un procedimiento común para tratar patologías urinarias obstructivas benignas.',2 Al material obtenido se le practica estudio histológico para confirmar la naturaleza benigna, pero en algunos casos se ha encontrado como hallazgo incidental un adenocarcinoma en estadios tempranos. No se sabe con claridad cuánto material debe procesarse o si la cantidad de tejido examinado aumenta la posibilidad de encontrar cáncer. El objetivo de este trabajo es determinar la frecuencia de adenocarcinoma incidental de próstata en pacientes sometidos a RTU por causa benigna. Reune 196 casos de RTU en los que se procesó en una segunda fase todo el tejido restante obtenido, describiendo las variables edad, peso del espécimen, número de láminas procesadas, niveles de PSA y categoría diagnóstica, la cual fue clasificada como negativa para maglinidad, PIN alto de grado y adenocarcinoma de próstata estadios Tla y Tlb. Se encontró que la frecuencia de cáncer próstata en pacientes a quienes se les realizó RTU por hiperplasia prostática benigna en el Hospital de San José fue muy baja, dos pacientes de 71 y 80 años, además de otro que corresponde a una neoplasia intraepitelial de alto grado (PIN de AG) con niveles normales de PSA, lo que evidencia que la frecuencia es menor que la reportada en la literatura internacional. 3 '4 Abreviaturas: CIP, carcinoma incidental de próstata; RTU, resección transuretral de próstata; PIN AG neoplasia intraepitelial prostática de alto grado; PSA, antigeno especifico prostático; TNM, sistema de clasificación de estadio tumoral (T: tumor, N : ganglios linfáticos, M: metástasis). AU - Yaspe, Edgardo AU - Campo, Piedad del Carmen AU - Polo, José Fernando DO - 10.31260/repertmedcir.v18.n2.2009.532 IS - 2 KW - abreviaturas KW - alto grado KW - antigeno especifico prostático KW - antigeno específico prostático KW - carcinoma de próstata KW - carcinoma incidental de próstata KW - cip KW - de próstata KW - grado KW - hallazgo incidental KW - hiperplasia prostática benigna KW - intraepitelial prostática de alto KW - neoplasia intraepitelial prostática de KW - pin ag neoplasia KW - psa KW - resección transuretral KW - resección transuretral de próstata KW - rtu KW - sistema de clasificación de KW - tnm PY - 2009 SP - 70 EP - 75 TI - Adenocarcinoma incidental de próstata en resección transuteral por causa benigna: Hospital de San José, julio 2006 a marzo 2008 T2 - Revista Repertorio de Medicina y Cirugía VL - 18 ER - TY - JOUR AU - Acuña, E AU - Morales, Silva, M AU - Olivares, R AU - Vicherat, C AU - E, Sarras AU - San Martin, R AU - Diaz-Valdes, R AU - Valdivia, P IS - 2 PY - 2003 SP - 193 EP - 198 TI - Manejo quirurgico transvesical de la hiperplasia prostatica benigna. servicio de urologia hospital barro luco-trudeau T2 - Revista Chilena de Urología VL - 68 ER - TY - JOUR AB - Antecedentes. Desde la introducción de la detección del antígeno prostático específico (PSA) para la detección del adenocarcinoma prostático (PCA), ha habido un aumento en la incidencia de PCA en etapa T1c. El propósito de este estudio fue comparar la frecuencia de PCA incidental encontrada en las muestras de resección transuretral de próstata (RTUP) durante un período de 14 meses durante 1989–1990 (antes de que la detección de PSA estuviera disponible) con la incidencia de PCA para un 32 de un mes durante 1997–1999 (después de que el examen de PSA estuvo disponible). Diseño. — Muestras consecutivas de RTUP a partir del tiempo 2 Se revisaron los períodos para identificar PCA incidental, neoplasia intraepitelial prostática (PIN) e hiperplasia adenomatosa atípica (AAH). Se excluyeron del estudio los casos de RTUP para el tratamiento paliativo de la PCA avanzada conocida. Todas las muestras de RTUP se fijaron en formol tamponado al 10% y se procesaron de acuerdo con el mismo protocolo. Resultados. — Revisamos las muestras 533 y 449TURP para los períodos de tiempo 1989–1990 y 1997–1999, respectivamente. La comparación de los resultados para estos 2 períodos de tiempo reveló que la prevalencia combinada de T1a y T1b PCA disminuyó con el tiempo de 12.9% a 8.0% (P ⴝ .06) con la introducción de la detección de PSA. Se estableció un nuevo grupo de T1c PCA en el período de detección post-PSA de 1997-1999. No hubo diferencias estadísticamente significativas en la incidencia de T1a PCA, PIN y AAH en especímenes de TURP durante los 2 períodos de tiempo. Conclusión. — La disminución de la incidencia de T1b PCA en Las muestras de RTUP para el período 1997-1999 representan un cambio en la estadificación de PCA. Algunas PCA previamente clasificadas como T1b ahora se clasifican como carcinomas T2, como resultado de la detección de PSA y la detección clínica anterior. La introducción de la detección de PSA no ha influido en la incidencia de T1a PCA, PIN o AAH en muestras de RTUP. AU - Mai, Kien. T. AU - Isotalo, Phillip. A. AU - Green, Jerome. AU - Perkins, D. G. AU - Morash, Christopher. AU - Collins, Jhon. P. DO - 10.1043/0003-9985(2000)124<1454:IPAAPP>2.0.CO;2 IS - 10 PY - 2000 SP - 1454 EP - 1456 TI - Incidental prostatic adenocarcinomas and putative premalignant lesions in TURP specimens collected before and after the introduction of prostrate-specific antigen screening T2 - Archives of Pathology and Laboratory Medicine VL - 124 ER - TY - JOUR AB - Objetivos Evaluar retrospectivamente la efectividad de la resección transuretral de la próstata (RTUP) en el diagnóstico del cáncer de próstata en pacientes con síntomas de evacuación obstructiva y antecedentes de biopsia de próstata transrectal negativa pero elevado antígeno prostático específico (PSA) y / o examen rectal digital anormal (DRE) ) Métodos. En 1189 pacientes consecutivos sometidos a RTUP o prostatectomía abierta entre 1994 y 2000 por síntomas de micción obstructiva, identificamos 445 pacientes (37,4%) con al menos un conjunto previo de biopsias de próstata transrectal debido a un nivel elevado de PSA y / o hallazgos anormales de DRE. La probabilidad de detectar cáncer de próstata mediante RTUP (n ⫽ 423; 95%) o cirugía abierta (n ⫽ 22; 5%) se investigó en general, así como en relación con la edad del paciente, el nivel de PSA, los hallazgos de DRE, el número de biopsias, tiempo desde la biopsia hasta la cirugía y el peso del tejido resecado. Resultados El número medio de biopsias negativas preoperatorias por paciente fue de 1,6 (rango 1 a 8). La edad media del paciente fue de 69 años (rango 48 a 89). La mediana del nivel de PSA y el peso de resección fue de 8,64 ng / ml y 32 g, respectivamente. Noventa y siete pacientes (21.8%) tenían hallazgos anormales de DRE. En general, se detectó cáncer de próstata en 35 pacientes (7,9%). La incidencia de cáncer fue del 5.5% (19 de 348) en pacientes con un DRE normal en comparación con el 16.5% (16 de 97) en pacientes con un DRE anormal (P ⬍0.001; prueba exacta de Fisher). La tasa de cáncer también se relacionó con la edad; otros subgrupos no mostraron diferencias estadísticamente significativas con respecto a la incidencia de cáncer. Conclusiones En pacientes con biopsias previamente negativas, el rendimiento diagnóstico de RTUP es bajo. Por lo tanto, la RTUP para fines de diagnóstico solo no se puede recomendar. Sin embargo, en pacientes con DRE anormal y síntomas obstructivos, se debe preferir la cirugía a las opciones de tratamiento alternativas. AU - Zigeuner, Richard AU - Schips, Luigi AU - Lipsky, Katja AU - Auprich, Marko AU - Salfellner, Michael AU - Rehak, Peter AU - Pummer, Karl AU - Hubmer, Gerhart DO - 10.1016/S0090-4295(03)00663-0 IS - 5 PY - 2003 SP - 883 EP - 887 TI - Detection of prostate cancer by TURP or open surgery in patients with previously negative transrectal prostate biopsies T2 - Urology VL - 62 ER - TY - BOOK AB - Este documento se ha elaborado en el marco del convenio interadministrativo 550 del 2013 sostenido entre el Ministerio de Salud y Protección Social y el Instituto Nacional de Cancerología ESE. AU - Ministerio de Salud y Protección Social AU - Instituto Nacional de Cancerología PY - 2015 SN - 9789588963020 SP - 31 EP - 61 TI - Manual para la detección temprana del cáncer de próstata T2 - Instituto Nacional de Cancerología UR - http://www.cancer.gov.co/files/libros/archivos/Piel ER - TY - BOOK AB - El Instituto Nacional de Cancerología presenta el Atlas de mortalidad por cáncer correspondiente al periodo 2007-2013. Previo a los análisis se revisó la calidad de la certificación de la mortalidad. Esta se calculó a partir de las bases de datos oficiales de mortalidad del DANE. AU - Pardo, Constanza AU - De Vries, Esther AU - Buitrago, Lina AU - Gamboa, Óscar PY - 2017 SN - 9789588963129 SP - 124 EP - 124 TI - Atlas de mortalidad por cáncer en Colombia. Cuarta Edición UR - https://www.cancer.gov.co/ATLAS_de_Mortalidad_por_cancer_en_Colombia.pdf ER - TY - JOUR AB - Xubias de Arriba s/n La Coruña. (España) efrosado@ozu.es Trabajo recibido: 27 de mayo 2005 Resumen.-OBJETIVO: Determinar la prevalencia de cáncer de próstata incidental tras biopsia prostática transrectal ecodirigida y posterior adenomectomía pros-tática suprapúbica, y compararlo con la prevalencia de un grupo similar de pacientes que no fueron biopsiados previamente a la cirugía. Evaluar el tratamiento, la evo-lución y las progresiones de la enfermedad tumoral en los pacientes con cáncer de próstata incidental. MÉTODOS: Estudio retrospectivo de 549 adenomec-tomías suprapúbicas realizadas entre 1996-2001 (6 años), comparando el grupo de pacientes biopsiados previamente a la adenomectomía con el grupo no biop-siado. RESULTADOS: 291 (53%) pacientes no fueron biopsia-dos previamente a la adenomectomía. 258 (47%) fue-ron biopsiados. 25 cánceres de próstata incidentales detectados, 19 (76%) en el grupo de los no biopsiados y 6 (24%) en el de los biopsiados. 88% pT1a y 12% pT1b. Gleason medio 4,5 (3-7). No fueron tratados el 84% de los pacientes (21) ("esperar y ver"); bloqueo hormonal 8% (2); finasteride 8% (2). Progresaron 3 pacientes (12%), todos del grupo de los no tratados. Media de seguimiento de 48,1 meses (22-96). No se detectó ningún caso de mortalidad cáncer de próstata específico. CONCLUSIONES: La prevalencia global de cáncer de próstata incidental en nuestra serie en pacientes a los que se les realizo adenomectomía prostática suprapú-bica fue del 4,55%. La prevalencia fue mayor en el grupo de pacientes no biopsiados previamente a la adenomectomía (3,46%) que en el grupo de los biop-siados (1,09%). La progresión tumoral fue del 12% y la supervivencia cáncer de próstata específica del 100% tras una media de seguimiento de 48,1 meses (22-92). La biopsia prostática previa a la adenomectomía en pa-cientes con tacto rectal sospechoso o PSA elevado dis-minuye la prevalencia de cáncer prostático incidental. El seguimiento expectante activo puede ser una actitud valida en determinados casos. Palabras clave: Cáncer próstata incidental. Adeno-mectomía prostática. Biopsia prostática. Summary.-OBJECTIVES: To establish the prevalence of incidental prostate cancer after transrectal ultrasound guided prostatic biopsy and subsequent suprapubic prostatic adenomectomy and to compare it with a similar group of patients who did not underwent biopsy before surgery. To evaluate treatment, outcomes, and disease progression in patients with incidental prostate cancer. AU - Fernández Rosado, Enrique AU - Gómez Veiga, Francisco AU - Álvarez Castelo, Luis AU - Ruibal Moldes, Manuel AU - Manuel Mosquera Reboredo, Juan AU - González Martin, Marcelino AU - Fernández Rosado Servicio de Urología Hospital Juan Canalejo, Correspondencia E PY - 2006 SP - 1 EP - 31 TI - Prevalencia de adenocarcinoma prostatico incidental tras adenomectomia suprapubica con o sin biopsia prostatica previa T2 - Urología Oncológica Arch. Esp. Urol VL - 59 ER - TY - JOUR AU - Rodríguez-Carrillo, Sara AU - Ríos-Burgueño, Efrén Rafael AU - Soto-Sañudo, Ana Karen AU - Benítez-Morales, Ana cristina IS - 4 PY - 2016 TI - Cancer prostatico incidental en biopsias obtenidas por reseccion transuretral de prostata con diagnostico de hipérplasia prostatica benigna T2 - Rev Med UAS VL - 6 ER - TY - GEN AU - Retamales Garcia, Ena Carolina AU - Plaza Alcivar, Akemi Rocio CY - Guyaquil DA - 2015/5// PY - 2015 TI - Recidiva de hiperplasia prostatica benigna tras adenomectomia por via retropubica vs reseccion trasuretral prostatica en el hospital teodoro maldonado carbo, Guayaquil 2010-2014 ER - TY - GEN AB - Antecedentes: La hiperplasia prostática benigna (HPB) es uno de los problemas de salud más prevalentes de la población masculina cuyo riesgo de que ocurra se incrementa por encima de los 50 años de edad. Son múltiples los tratamientos existentes para su manejo, de los cuales el quirúrgico prevalece por su efectividad. Objetivo: Siendo la resección transuretral prostática (RTUP) y la adenomectomía retropúbica (AR) las técnicas más utilizadas hasta la actualidad para el tratamiento de la HPB, ha sido preciso cuestionar su eficacia identificando cuan frecuente los pacientes sometidos a estas técnicas requieren ser reintervenidos por recidiva y analizar las complicaciones postquirúrgicas y variables modificables que promuevan la recidiva de HPB. Métodos: Se realizó un estudio retrospectivo, los expedientes clínicos de 1462 pacientes con HPB sintomática e intervenidos por AR o RTUP en el Hospital Teodoro Maldonado Carbo durante el período 2010-2014, y bajo criterios de inclusión fueron escogidos 280 pacientes para el estudio. Resultados: 280 pacientes intervenidos en 2 grupos. Del grupo 1 (n=144) con AR se obtuvo una prevalencia de recidiva del 2.08%, con un tiempo de recuperación postquirúrgica de 8 días. El grupo 2 (n=136) con RTUP se obtuvo una prevalencia de recidiva del 11,03% y tiempo de recuperación postquirúrgico de 5 días. La complicación inmediata más frecuente fue la hematuria en ambos procedimientos, mientras que las complicaciones mediatas más frecuentes fueron la estenosis uretral, revisando AU - Retamales Garcia, Ena Carolina AU - Plaza Alcivar, Akemi Rocio PY - 2015 SP - 41 EP - 41 TI - Recidiva de hiperplasia prostatica benigna tras adenomectomia por via retropubica vs reseccion trasuretral prostatica en el hospital teodoro maldonado carbo, Guayaquil 2010-2014 ER - TY - BOOK AU - Sistema General de Seguridad Social en Salud CY - Bogota PY - 2013 SN - 9789588838403 SP - 717 EP - 717 TI - Guía de práctica clínica ( GPC ) para la detección temprana , seguimiento y rehabilitación del cáncer de próstata ER - TY - JOUR AU - Piza Rodriguez, Julio Roberto IS - 7 PY - 2014 SP - 231 EP - 277 TI - La función de fiscalización tributaria en Colombia T2 - Revista de Derecho Fiscal VL - 0 ER - TY - GEN AU - Instituto Colombiano Agropecuario PY - 2019 SP - 2 EP - 2 TI - Respuesta peticion ICA.pdf ER - TY - GEN AU - DANE PY - 2018 SP - 2 EP - 2 TI - Respuesta derecho de peticion ER - TY - JOUR AU - Irigoin, Alejandra IS - 6 PY - 2010 SP - 919 EP - 979 TI - La raices monetarias de la fragmentacion politica de las america española en el siglo XIX T2 - Historia Mexicana VL - 59 ER - TY - JOUR AB - RESUMEN En la actualidad, la aplicación del concepto de calidad a los servicios de salud gana cada vez más importancia. Sin embargo, implementar un sistema para su gestión no es tarea fácil y requiere de un cambio cultural de la organización que involucre a todos los actores de la institución en aras de satisfacer las necesidades y preferencias de los pacientes. El desempeño en calidad se sustenta en la medición de resultados, de procesos y de la satisfacción de los pacientes y sus familias, y su meta es lograr la mejora continua. Existen muchos factores a considerar al momento de potenciar el desempeño con calidad, pero los esfuerzos deben orientarse a cómo se hacen las cosas, estandarizar procesos, acreditar servicios. Estas herramientas permitirán mejorar el trato y disminuir los errores clínicos y administrativos, lo cual posibilitará tener un mejor manejo, que sin duda será reconocido por la población. Seguir trabajando para mejorar la satisfacción del cliente externo, la relación con los pacientes y sus familias, localizar y disminuir los errores, trabajar en equipo, hacer partícipe a todos, sentirse parte de una organización que nos necesita y que avanza hacia los nuevos cambios que el sistema y el mundo necesitan, son la esencia de la cultura de calidad. Palabras clave: calidad, calidad de los servicios de salud, gestión de la calidad. ABSTRACT At present, the application of the concept of quality in health services is more important every day. Nevertheless, the implementation of a system in this sense is not aneasy task and it requires a cultural change of the organization involving everyone in the institution so as to satisfy all needs and preferences of the patients.The essence of a quality performance is based on the measurement of results, processes and in patients' and relatives'satisfaction, and the goal is to achieve constant improvement. Many aspects are to be considered in order to accomplish the AU - Mariela, Msc AU - Barrios, Forrellat IS - 2 PY - 2014 SP - 179 EP - 183 TI - Calidad en los servicios de salud: un reto ineludible T2 - Revista Cubana Hematología, Inmunología y Hemoterapia UR - http://scielo.sld.cu VL - 30 ER - TY - JOUR AB - En la actualidad se habla mucho de calidad, todos queremos productos y servicios de calidad; asimismo, se habla de certificación y acreditación como una forma de garantía de calidad. Aunque en estos momentos esta de moda, el concepto de calidad no es nuevo y ha sido una preocupación permanente desde la antigüedad, y probablemente la idea de calidad es tan antiguo como el hombre mismo. Desde la elaboración de los utensilios para la caza, de la vestimenta y otros hay evidencias de evolución y mejora de la calidad. Sin embargo, esto es mas notorio con el auge del comercio de productos entre las civilizaciones. El concepto de calidad desde sus inicios y hasta hace muy poco tiempo, ha estado relacionado al producto mismo y ha sido utilizado para describir atributos tales como la belleza, la bondad, el alto precio, y sobre todo, el lujo (1). Pero, ¿Qué es calidad?. Etimológicamente, la palabra calidad proviene del latín qualitas o qualitatis, que significa perfección (2). El Pequeño Larousse ilustrado define calidad como el conjunto de cualidades de una persona o cosa (3). En estas definiciones se concibe a la calidad como un atributo o características que distingue a las personas, a bienes y a servicios. Veamos algunas definiciones de la calidad según algunos expertos. E. Deming dice: "la calidad es el orgullo de la mano de obra", entendiendo mano de obra en el mas amplio sentido y agrega que "la calidad se define en términos de quien la valora" (4). P. Crosby, dice: "La calidad debe definirse como ajuste a las especificaciones y no como bondad o excelencia" (5) y J. Juran define calidad como "aquellas características que responden a las necesidades del cliente y la ausencia de deficiencias" (5). Como podemos apreciar definir calidad no es fácil. En la práctica, tal como lo refiere R. Schonberger, "la calidad es como el arte; todos la alaban, todos la reconocen cuando la ven, pero cada uno tiene su propia definición de lo que es". El organismo internacional de normalización ISO, en su norma 8402, ha definido a la calidad como la totalidad de características de una entidad que le confiere capacidad para satisfacer necesidades explícitas e implícitas. La norma precisa que entidad es una organización, llámese empresa o institución, producto o proceso y los elementos que conforman las necesidades son básicamente: seguridad, disponibilidad, mantenibilidad, confiabilidad, facilidad de uso, la economía (precio) y el ambiente. La definición de calidad ha ido cambiando, de ser el producto el aspecto central, luego el control de los procesos de producción para finalmente llegar al concepto de calidad total. En el mundo actual solo existe un punto central clave para las instituciones: el cliente, por lo tanto la calidad la definen los clientes y solo las instituciones que se centran en los requisitos de sus clientes sobrevivirán en el futuro (1). AU - Miyahira, J IS - 3 PY - 2001 SP - 75 EP - 77 TI - Calidad en los servicios de salud ¿Es posible? T2 - Rev Med Hered VL - 12 ER - TY - BOOK AU - Restrepo, Libia J PY - 2006 SN - 978-958-97811-5-9 TI - Médicos y comadronas o el arte de los partos. La ginecología y la obstetricia en antioquia, 1870-1930 UR - https://www.magisterio.com.co/libro/medicos-y-comadronas-o-el-arte-de-los-partos-la-ginecologia-y-la-obstetricia-en-antioquia-1870 ER - TY - GEN AU - DANE PY - 2020 TI - Atributos de la Calidad en la Atención en Salud T2 - DANE UR - https://www.minsalud.gov.co/salud/Paginas/ATRIBUTOS-DE-LA-CALIDAD-EN-LA-ATENCIÓN-EN-SALUD.aspx ER - TY - JOUR AB - The trend of maternal mortality rate in the municipality of Uribia, Department of Guajira, Colombia, has shown a dizzying increase. Although there are efforts to improve the coverage of childbirth occurring in institutions of the municipality, home deliveries, which are a normal cultural practice in indigenous populations such as the Wayúu, remains, for various reasons, the first option for a significant number of Wayúu women. This cultural practice exposes women to complications during childbirth care, which, if not sent to a hospital in time, can result in maternal death. The objective of the present study was to describe the behavior of maternal mortality in the pregnant Wayúu of the municipality of Uribia in the period between January 1st, 2010 and December 31, 2016. The results of this study show how traditional practices of childbirth, the difficulty of access to health services and the mother´s age are factors that contribute to increase the maternal mortality rate and this, in turn, reveals the social and health vulnerability to which this indigenous community is exposed. The study also concluded that postpartum hemorrhage (PPH) was the main cause of maternal mortality in the pregnant woman Wayuu of the municipality of Uribia, during the period studied. Home care at the delivery, performed by mothers, grandmothers or older sisters, can be a trigger for this type of obstetric complications that, if not addressed properly, can lead to the death of the mother. AU - Bula Romero, Javier Alonso AU - Galarza, Keiner IS - 1 KW - Characteristics KW - Cultural KW - Health of Indigenous Peoples. KW - Maternal Mortality KW - Pregnant Women PY - 2017 SP - 46 EP - 52 TI - Mortalidad Materna En La Gestante Wayúu De Uribia, Departamento De La Guajura, Colombia. T2 - Enfermería: Cuidados Humanizados VL - 6 ER - TY - JOUR AU - Bula Romero, Juan AU - Galarza, Keiner KW - características culturales KW - mortalidad materna KW - mujeres embarazas KW - salud de poblaciones indígenas PY - 2017 TI - Mortalidad materna en la gestante Wayúu de Uribia, despartamento de La Guajira, Colmbia. Estudio descriptivo año 2016. Revista Enfermería: Cuidados Humanizados [Revista On-line] junio 2017 [fecha de consulta: 2017]; 6 (1): ISSN: 1688-8375 VL - 6 ER - TY - JOUR AB - Objective: identify perceptions and possible risk factors in regards to pregnancy as part of the sexual and reproductive health (SSR) of expectant Indigenous mothers who live in the shores of the Amazon River, in order to plan, project and evaluate the impact of future programs for the promotion and prevention of their SSR. Methods: study, through Busqueda -Activa- Comunitaria (BAC) Active Community Search of all the expectant mothers in the nineteen Indigenous communities of the area, application of survey of knowledge, attitude and practices (CAP) with the previous informed consent and risk evaluation of each expectant mother. Systematization and analysis with Epi-Info 3.5.1, using measures of frequency and central tendencies. Results: 73 expectant mothers located in the BAC, of the Ticuna ethnic group (56.2%), Cocama (19.2%), Yagua (8.2%), Huitoto (2.7%), Ocama (1.4%), and mixed ancestry (12.3%); distributed by age groups 16 - 18 (20.5%), 19 - 26 (41.1%), 27 - 34 (26.0%), and 35 - 48 (12.3%). Prenatal control: inadequate (64.4%), without control (21.0%). Births: in the last two years (74%); more than four (28.8%); post partum birth control with shots (38.1%), tubal ligation (23.8%) Conclusion: evidence of a high percentage of expectant mothers under risk, according to their age and incomplete prenatal control was clear. The strengthening and reinforcement of the strategies of information - communication - education and the creation of didactic materials with a plain-simple-graphic language in order to educate the expectant mothers, was recommended. (English) [ABSTRACT FROM AUTHOR] AU - Acosta Infante, Yenica AU - Segura, Omar DO - 10.33132/01248146.252 IS - 22 KW - Actitudes y Prácticas en Salud KW - Conocimientos KW - Embarazo.>>>Sexual and Reproductive Health KW - Indigenous Health KW - Kn... KW - Salud Indígena KW - Salud Sexual y Reproductiva PY - 2011 SP - 108 EP - 120 TI - Indigenas gestantes en la ribera del amazonas, Colombia, 2009: conocimientos, actitudes y prácticas T2 - Revista Investigaciones Andina (En línea) VL - 13 ER - TY - JOUR AB - INTRODUCTION Little is known about the CD40L-CD40 pathway in hematologic malignancies, especially in multiple myeloma (MM). OBJECTIVES The aim of the current study was to evaluate serum soluble CD40 ligand (sCD40L) concentrations in patients with newly diagnosed MM prior to treatment at different stages of disease, compared with healthy controls. To assess the clinical significance of sCD40L, we assessed correlations between the levels of sCD40L and those of angiogenic cytokines: interleukin 6 (IL-6), soluble receptor of IL-6 (sIL-6R), tumor necrosis factor α (TNF-α), soluble vascular cell adhesion molecule 1 (sVCAM-1), and platelet-derived growth factor AB (PDGF-AB), as well as with well-established biomarkers of MM activity (lactate dehydrogenase activity and percentage of bone marrow plasma cells) and with a marker of platelet activation (β-thromboglobulin). PATIENTS AND METHODS The study group consisted of 41 patients with newly diagnosed MM; the control group consisted of 30 healthy subjects. The level of sCD40L was determined using an enzyme-linked immunosorbent assay. RESULTS The level of sCD40L was significantly higher in patients with MM than in controls and increased with the stage of the disease. Moreover, it significantly correlated with the levels of IL-6, sIL-6R, sVCAM-1, PDGF-AB, as well as the levels of MM activity markers and β-thromboglobulin. CONCLUSIONS Our findings indicate that increased serum sCD40L levels may be related to angiogenesis in patients with MM. This protein has potential clinical usefulness in MM and may be considered as an additional prognostic marker. The correlation of sCD40L with β-thromboglobulin may indicate that in patients with MM sCD40L derives from activated platelets. AU - Cevallos, Rodrigo AU - Amores, Alfredo PY - 2009 SN - 1078-5884 SP - 92 EP - 92 TI - Prestación de servicios de salud en zonas con pueblos indígenas T2 - Area de Tecnología, Atención de la Salud e Investigación Programa Regional Salud de los Pueblos Indígenas, Organización Panamericana de Salud, Organización Mundial de la Salud UR - https://www.paho.org/ecu/index.php? option=com_docman&view=download&category_slug=salud-de-los-pueblos-indigenas-de-las-americas&alias=161-presentacion-de-servicios-de-salud-en-zonas-con-pueblos-indigenas&Itemid=599 ER - TY - JOUR AU - López Cuesta, Laura IS - 1 KW - Cohesión Social. KW - Etnodesarrollo KW - Investigación- Acción-Participativa KW - Participación KW - Plan de Vida PY - 2012 SP - 8 EP - 8 TI - Elaboración participativa del Plan Integral de vida del resguardo de Lomamato – Guajira T2 - Horizontes Pedagógicos VL - 14 ER - TY - JOUR AU - Leininger, Madeleine DO - 10.1097/00152193-198008000-00001 IS - 8 PY - 1980 SP - 4 EP - 4 TI - Transcultural nursing, concepts, theories, research & practices T2 - Nursing VL - 10 ER - TY - JOUR AU - Oviedo C, María del Pilar AU - Hernández Q, Andrea AU - Mantilla U, Blanca P AU - Arias P, Karen N AU - Flórez G, Nieves Z IS - 2 PY - 2014 SP - 17 EP - 25 TI - Communities Wounaan and Embera Chocó department: care practices during pregnancy T2 - Revista Facultad Nacional de Salud Pública VL - 32 ER - TY - GEN AU - Comisión Económica para América Latina y el Caribe PY - 2010 SP - 3 EP - 64 TI - Salud materno-infantil de pueblos indígenas y afrodescendientes de América Latina: aportes para una relectura desde el derecho a la integridad cultural T2 - Cepal/Celade.Unfpa ER - TY - JOUR AB - INTRODUCCIÓN La hemorragia postparto es una de las complicaciones más temidas que pueden surgir en el puerperio. Actualmente, la me-jor atención obstétrica y la mayor disponi-bilidad y mejor uso de fármacos oxitócicos, han hecho que su incidencia no supere el 5% (los análisis estadísticos más optimistas calculan cifras en torno al 1%), si bien hay que tener en cuenta que estas cifras corres-ponden a estadísticas realizadas en países desarrollados. De todos modos sigue siendo una de las tres primeras causas de mortali-dad materna en el mundo, siendo en la ma-yoría de los casos potencialmente evitable. HEMORRAGIA POST-PARTO Existe una ausencia de uniformidad de criterio a la hora de definir la hemorragia post-parto, aceptándose varias definicio-nes en cuanto a diferentes parámetros se estimen. Una de las más universalmente aceptadas es aquella que define la hemo-rragia postparto como la pérdida hemáti-ca superior a 500 ml tras un parto vaginal o a 1.000 ml tras una cesárea. Esta defini-ción clásica presenta el inconveniente de la subjetividad del clínico, quien tiende a subestimar estas cifras. Es por ello que se hace necesario y recomendable añadir que la hemorragia postparto es, además de un sangrado excesivo, aquella que re-percute en la paciente y la hace presentar síntomas y/o signos evidentes de hipovo-lemia. Otros parámetros han ido cayendo en desuso, como es el caso de la cuantía de hemoglobina y/o hematocrito, los cua-les tienen la limitación de depender del momento preciso de su determinación y de los volúmenes previos al parto. A su vez, es necesario distinguir entre hemorragia postparto precoz y tardía. La hemorragia postparto precoz es aquella que ocurre durante las primeras 24 horas tras el parto. La tardía es la que acontece después de 24 horas tras el parto hasta 6 semanas tras el mismo. Esta revisión se centrará prin-cipalmente en las causas y tratamientos de la hemorragia postparto primaria (HPP), por ser generalmente más grave. AU - Futcher Soruco, Carlos Eduardo AU - Ortiz Lizcano, Edgar Iván AU - Escobar Vidarte, Maria Fernanda AU - Díaz de León, Heriberto Lizaola IS - 609 PY - 2009 SP - 9 EP - 130 TI - Hemorragia Post-Parto T2 - Flasog UR - http://scielo.isciii.es/pdf/asisna/v32s1/obstetricia6.pdf ER - TY - JOUR AB - OBJECTIVE: To document the beliefs and practices of traditional midwifes in regard to pregnancy, delivery and puerperium. METHOD: Taking advantage of a training course for 160 local traditional midwives from the Media and Huasteca regions of San Luis Potosí State, Mexico. Two of the teacher-nurses interviewed 25 of them, supported by a member of Náhuatl and Tenek communities. The participant's identity was kept anonymous and permit for publications of results was obtained by informed consent. RESULTS: Traditional midwifes practices are common in social groups lacking health services. Their role is not limited to delivery and includes nursing, prenatal and puerperium care, as well as emotional and affective support to delivering mothers and their families. In this study several myths and traditional therapies were registered. CONCLUSION: The traditional therapy and primary health care resources of the Náhuatl and Tenek midwifes are useful and harmless for the perinatal care. AU - Pelcastre, Blanca AU - Villegas, Norma AU - De León, Verónica AU - Díaz, Agustín AU - Ortega, Doris AU - Santillana, Manuel AU - Mejia, Juana de los Angeles DO - 10.1590/s0080-62342005000400002 IS - 4 PY - 2005 SP - 375 EP - 382 TI - Embarazo, parto y puerperio: creencias y prácticas de parteras en San Luis Potosí, México. T2 - Revista da Escola de Enfermagem da U S P. VL - 39 ER - TY - JOUR AB - Resumen El presente artículo se inscribe dentro de la perspectiva de la antropología de la medicina, disciplina que se interesa por describir, analizar e interpretar todo lo relacionado al mundo médico, a la enfermedad, su origen, curación y prevención. Este trabajo analiza cómo conciben los wayúu (grupo indígena ubicado en la frontera entre Venezuela y Colombia) a las personas a las cuales acuden para encontrar solución a alguna enfermedad. Dado que ante el contacto con el criollo en general, y en la búsqueda de soluciones a la enfermedad en particular, los wayúu han redimensionado muchas de sus costumbres, insertando algunas de otras culturas y eliminando algunas propias, ahora se encuentran en un conflicto permanente entre sus tradiciones para enfrentar sus enfermedades y las opciones curativas que ofrece el modelo biomédico occidental. Descriptores: Antropología de la medicina, enfermedad, curación. Abstract From the perspective of anthropology of medicine-which describes, analyzes and interprets the medical dimension of social groups, especially the origin, cure and prevention of illness-, this paper analyzes the Wayúu conception of the people they turn to in order to find a cure to their illnesses; the Wayúu Indians (Arawak) live on both sides of the Colombian-Vene-zuelan border. Due to the contact with the mestizo culture, in general, and in their search for cure their illnesses in particular, the Wayúu have adjusted many of their healing practices; they have abandoned some of them and have adopted alien ones. As a result they now find themselves in permanent conflict between their traditions and the alternatives offered by the Western biomedical model. Descriptors: Antropology of medicine, illness, cura. AU - Rincon Soto, Máster Lucia IS - 59 KW - Antropology of medicine KW - Antropología de la medicina KW - Artículo revisado por pares KW - cura. KW - curación. KW - enfermedad KW - illness KW - info:eu-repo/semantics/article KW - info:eu-repo/semantics/publishedVersion PY - 2007 SP - 19 EP - 33 TI - Enfermarse y curarse en la guajira: la salud entre tradición y modernidad T2 - Revista PRAXIS VL - 0 ER - TY - GEN AU - Cunningham Kain, Mirna PY - 2002 SP - 1 EP - 46 TI - La experiencia de la salud intercultural como una herramienta para la equidad en las Regiones Autónomas de Nicaragua. T2 - Dia Mundial de la Salud ER - TY - JOUR AB - Resumen: Este artículo busca determinar el impacto sociocultural de las políticas públicas y la modernización en salud y educación en los pueblos aimaras en Chile, desde un enfoque cultural. Su intención es aproximarse al significado atribuido por las mujeres aimaras de Colchane a las políticas públicas en salud reproductiva y cómo impacta en su cosmovisión. Nuestra hipótesis es que las mujeres aimaras no se apropian de las políticas culturales en salud reproductiva porque no responden al sentido cultural que involucra el proceso reproductivo. Este trabajo quiso indagar sobre el sentido social y la construcción valórica tras estos procesos sociales y determinar cómo afecta a la incorporación de las políticas públicas. Palabras clave: aimara, mujer, salud, salud intercultural INTERCULTURAL HEALTH: THE IMPACT IN THE AIMARA WOMEN SOCIAL IDENTITY Abstract: This paper is part of a research project which tries to determine the socio cultural impact of public policies and the modernization process in the health care of the aimara ethnic group in Chile, from a cultural perspective. Its purpose is to approach to the meaning attributed by the aimara women from Colchane to the public policies related to reproductive health and how it impacts their cosmic vision. Our hypothesis is that the aimara women do not appropriate these public policies on reproductive health as proper because they do not respond to their cultural meaning about the reproductive process. Resumo: Este artigo procura determinar o impacto socio-cultural das políticas públicas, a modernização em saúde e a educação nos povos Aimaras no Chile, desde um enfoque cultural. Seu objetivo é se aproximar do significado atribuido pelas mulheres Aimaras de Colchane às políticas públicas em saúde reprodutiva e como impacta em sua cosmovisão. Nossa hipótese é que as mulheres Aimaras não se apropriam das políticas culturais em saúde reprodutiva porque não respondem ao sentido cultural que envolve o processo reprodutivo. Este trabalho quis indagar sobre o sentido social e a construção de valores através destes processos sociais e determinar como isto afeta a incorporação das políticas públicas. AU - Valdebenito, Carolina AU - Rodríguez, Marilyn AU - Hidalgo, Andrea AU - Cárdenas, Ulises AU - Lolas, Fernando DO - 10.4067/s1726-569x2006000200007 IS - 2 KW - aimara KW - aimara women social KW - intercultural health KW - mujer KW - salud KW - salud intercultural KW - the impact in the PY - 2006 SP - 185 EP - 191 TI - Salud Intercultural: Impacto En La Identidad Social De Mujeres Aimaras T2 - Acta bioethica VL - 12 ER - TY - JOUR AU - Castro, Roberto; Loya Martha IS - 27 PY - 1991 SP - 583 EP - 606 TI - Embarazo y parto entre la tradición y la modernidad: el caso de Ocuituco 1 T2 - Estudios Sociológicos UR - https://dialnet.unirioja.es/servlet/articulo?codigo=4470137 VL - 9 ER - TY - JOUR AU - Chavez Alvarez, Rocio Elizabeth AU - Arcaya MOncada, Maria Josefa AU - Garcia Arias, Gladys AU - Surca Rojas, Teresa Catalina AU - Infante Contreras, Maria Virginia IS - 4 KW - actitudes y KW - au- KW - conocimientos KW - infantil KW - población indígena KW - salud materno- KW - tocuidado PY - 2007 SP - 680 EP - 687 TI - Rescatando el autocuidado de la salud durante el embarazo, el parto y al recein nacido: representaciones sociales de mujeres de una comunidad nativa en Perú T2 - Texto Contexto Enferm VL - 16 ER - TY - JOUR AU - González Muñoz, Jenny IS - 2 KW - Pueblo indígena. Warao. Mitos de origen. Memoria. PY - 2014 SP - 91 EP - 106 TI - Mitos fundantes en la fuerza espiritual de los warao de Venezuela T2 - Patrimônio e Memória VL - 10 ER - TY - JOUR AB - Introducción. La atención prenatal aún no cubre al total de gestantes, situación que se repite en Latinoamérica y son pocos los estudios que evalúan las barreras que explican este fenómeno. El objetivo del presente estudio fue determinar los factores asociados al acceso de la atención prenatal en sus dimensiones de atención oportuna y cobertura. Métodos. Estudio de enfoque cuantitativo, observacional y analítico, realizado en 110 puérperas de los hospitales de Huaral y Chancay, Perú. Se evaluaron los factores (personales y sociodemográficos) asociados al acceso a la atención prenatal de acuerdo a su cobertura (mínimo 6 controles) y atención oportuna (primer control <14 semanas). Se realizó un análisis de regresión logística multivariada considerando un nivel de confianza del 95%. Resultados. Se halló que el olvido de las citas se muestra como un factor asociado a la cobertura inadecuada de la atención prenatal (p=0,048), mientras que la presencia de un seguro de salud, previo al control prenatal, se asoció a la atención prenatal oportuna (p=0,013). Conclusiones. La ausencia de olvido de las citas y la presencia de un seguro de salud previo al embarazo se asocian con el acceso a la atención prenatal. AU - Rivera Felix, Lauro Marcoantonio AU - Burgos López, Nancy Haydee AU - Gomez Diaz, Jossy Zulema AU - Moquillaza Alcántara, Victor Hugo DO - 10.15381/anales.v79i2.14939 IS - 2 KW - atención prenatal KW - decs KW - embarazo KW - salud materna PY - 2018 SP - 131 EP - 131 TI - Factores asociados al acceso a la atención prenatal en los hospitales de Huaral y Chancay, Perú T2 - Anales de la Facultad de Medicina VL - 79 ER - TY - JOUR AB - 145 Rev Peru Med Exp Salud Publica. 2009; 26(2): 145-60. PERCEPCIONES DEL PERSONAL DE SALUD Y LA COMUNIDAD SOBRE LA ADECUACIÓN CULTURAL DE LOS SERVICIOS MATERNO PERINATALES EN ZONAS RURALES ANDINAS Y AMAZÓNICAS DE LA REGIÓN HUÁNUCO Julio Mayca1,a, Elsa Palacios-flores2,b, Armando Medina1,c , José E. Velásquez3,a,d, Dick Castañeda 2,e RESUMEN La mortalidad materna, problema prioritario mundial, es mayor en países subdesarrollados con analfabetismo, zonas rurales poco accesibles e insuficiente personal de salud calificado. Objetivos. Este estudio explora las percepciones del personal de salud y la comunidad en relación con la adecuación cultural de servicios maternos perinatales en la región Huánuco, observando aspectos críticos de la oferta propuesta y las necesidades de la población. Materiales y métodos. Estudio exploratorio, transversal, cualitativo. Incluyó personal de salud a quienes se realizó entrevistas a profundidad (EP), y población en general para grupos focales (Gf ). Los instrumentos incluyeron aspectos como: adecuación y aceptación del servicio ofrecido, entendimiento y capacitación del personal en estos temas, y entendimiento de la población de las acciones y oferta en salud. Resultados. Se realizó 15 EP y 15 Gf ; en el primer caso el personal de salud refirió la poca adecuación de la infraestructura actual, mejora en la aceptación del servicio por la comunidad y la necesidad de tener ellos un mayor entendimiento del tema. La población manifestó su opinión acerca de lo poco adecuado del servicio ofertado a su cultura, poco entendimiento a las indicaciones médicas y deseos que se incorpore más a su cultura en dichos procesos. Conclusiones. Nuestros servicios maternos no tienen acondicionamiento adecuado con relación a la cultura de la comunidad, pues es insuficiente lo que una gestante podría encontrar en un consultorio relacionado con sus costumbres. Necesitamos considerar propuestas elaboradas desde la comunidad, para disponer de una oferta identificada con aspectos sociales, culturales, y étnicos, que sea identificada por la población como suya AU - Mayca, Julio AU - Palacios-Flores, Elsa AU - Medina, Armando AU - Velásquez, José E. AU - Castañeda, Dick IS - 2 KW - Cultural diversity KW - Maternal health services KW - Parturition KW - Peru (source: MeSH NLM) KW - Pregnancy KW - Rural settlements PY - 2009 SP - 145 EP - 160 TI - Percepciones del personal de salud y la comunidad sobre la adecuación cultural de los servicios materno perinatales en zonas rurales andinas y amazónicas de la región huánuco T2 - Revista Peruana de Medicina Experimental y Salud Publica VL - 26 ER - TY - JOUR AB - Objetivo: Nuestro país, por su riqueza cultural, presenta diversas concepciones en torno al embarazo, parto y puerperio. Las costumbres y los procesos de embarazo, parto y puerperio, de la mujer Awajun (Aguaruna) o Wampis (Huambisa), en el contexto cultural de las comunidades indígenas, son revisadas en el presente estudio. Materiales y métodos: Estudio etnográfico descriptivo, cualitativo, realizado durante octubre de 2002 a abril de 2003, aplicándose 24 entrevistas a profundidad (a parteras, promotores de salud y usuarias), en las comunidades de Puerto Galilea y Chapiza, además de tres grupos focales. Dichas entrevistas se analizaron en función de cinco aspectos, relacionados con señales, peligros, dietas y cuidados durante el embarazo, parto y puerperio. Resultados: Los pobladores reconocen algunas señales de peligro en el embarazo, como el sangrado vaginal y pérdida de líquido amniótico. Los cuidados durante el embarazo se relacionan con las actividades diarias y la ingesta de alimentos (dietas). Existen algunos elementos que dificultan el parto y nacimiento, como el sentimiento de vergüenza para llamar al promotor. Logrado el parto, debe mantenerse los cuidados para la recuperación de la madre, y un adecuado desarrollo del recién nacido. Conclusiones: Las concepciones y percepciones del embarazo, parto y puerperio en comunidades nativas, norman el comportamiento de sus pobladores, repercutiendo esto en la salud materna e infantil. Es necesario comprender esta cultura y capacitar agentes de medicina tradicional, implementando estrategias en promoción de la salud y atención de la gestante, fortaleciendo las capacidades institucionales e incrementando la cobertura. AU - Medina I, Armando AU - Mayca P, Julio DO - 10.17843/rpmesp.2006.231.1030 IS - 1 KW - activities of daily living KW - customs KW - health care KW - health promotion KW - medicine KW - natural childbirth KW - nursing KW - pregnancy KW - traditional medicine KW - vaginal bleeding KW - virology PY - 2006 SP - 22 EP - 32 TI - Creencias y costumbres relacionadas con el embarazo, parto y puerperio en comunidades nativas Awajun y Wampis T2 - Revista Peruana de Medicina Experimental y Salud Publica VL - 23 ER - TY - JOUR AB - El propósito de este artículo es mostrar y examinar algunos aspectos básicos de la situación que viven los pueblos indígenas y afrodescendientes en América Latina y el Caribe. A través del análisis de factores como el racismo y la discriminación, se intenta interpretar las causas que han determinado que millones de personas de la región,provenientes de diversos orígenes étnico-raciales,vivan en la pobreza y la marginación. Para enfrentar esta problemática,se plantea la necesidad de transformar las bases de los sistemas (culturales, económicos, legales y políticos);de exclusión y discriminación, diseñando estrategias que vayan desde el reconocimiento formal de las identidades y derechos colectivos hasta la formulación de po- líticas públicas,fortalecimiento de programas de cooperación regional e internacional y profundas reformas estatales. AU - Bello, Álvaro AU - Rangel, Marta DO - 10.18356/61fc0d54-es IS - 76 PY - 2002 SP - 39 EP - 54 TI - La equidad y la exclusión de los pueblos indígenas y afrodescendientes en América Latina y el Caribe T2 - Revista de la CEPAL VL - 2002 ER - TY - JOUR AB - An ethnographic research was carried out between 1997 and 2003, and during four months in 2008-2009, on the traditional medical systems of indigenous communities in the Amazonian Colombian departments of Guainía and Vaupés. Puinave, Curripaco, Piapoco, Guahibo, and Tucano groups were included. The work was based on community meetings, targeted groups, conversations with shamans and other leaders, home visits, and participation in traditional festivals. Analysis centered on the social, ecologic, and identity roles played by traditional indigenous medical systems; the latter are related with the maintenance of alternatives to the development discourse. The hegemony/subordination relationship that prevails between the Western and traditional medical systems is presented, evidencing how the latter has resignified itself, adapting to the contemporary intercultural context, thus questioning the biologist reductionism of official medicine. AU - Úsuga, C. R C IS - 1 KW - Ecological development KW - Ethnic group and health KW - Health systems KW - Medicine KW - Medicine, traditional PY - 2011 SP - 5 EP - 15 TI - Sistemas médicos tradicionales en la Amazonia nororiental: Salud y saberes alternativos T2 - Iatreia VL - 24 ER - TY - GEN AU - Machado Zeledón, Raúl Josué AU - Valerio, Saskia Betsy PY - 2017 SP - 79 EP - 79 TI - Creencias, mitos y prácticas que tienen las mujeres sobre el embarazo, parto y puerperio en el Centro de Salud Sócrates Flores Vivas, Enero a Marzo 2016 ER - TY - JOUR AU - Bravo, Muñoz AU - Felisa, Sandra AU - Escobar, Castro AU - Alexandra, Zindy AU - Narvaez, Chávez AU - Rodriguez, Ortega AU - Marcela, Diana KW - Cuidado prenatal, cultura, indígena, embarazada, c PY - 2012 SP - 39 EP - 44 TI - Artículos Originales Interculturalidad y percepciones ER - TY - JOUR AB - Objective. To identify and document access barriers to health care services for the indigenous population in Rabinal, Guatemala. Material and Methods. A qualitative analysis was used. Over a period of two months, 20 semi-directional interviews were conducted in Rabinal, Guatemala: 15 with Achis indigenous people and five with health professionals. A focus group was done to verify the information collected during the individual interviews. The qualitative analysis was based on the transcription of interviews and the compilation of the data. Results. Barriers to access are inter-relational. Geographic barriers include distance and a significant lack of means of transportation. Economic barriers are the cost of office visits and medicine. Among the cultural barriers, the Spanish language is an obstacle. Indigenous people have other concepts of medicine and treatments and they complain on occasion of abuse by health professionals. At the same time, health professionals recognize that the trauma of the civil war is still present and criticize the poor living conditions and the lack of resources. Conclusions. Health care services in Rabinal are inadequate and insufficient for responding to the needs of the local population. AU - Hautecoeur, Maeve AU - Zunzunegui, Maria Victoria AU - Vissandjee, Bilkis DO - 10.1590/s0036-36342007000200003 IS - 2 KW - Accessibility KW - Guatemala KW - Health services KW - Indigenous KW - Poverty PY - 2007 SP - 86 EP - 93 TI - Las barreras de acceso a los servicios de salud en la población indígena de Rabinal en Guatemala T2 - Salud Publica de Mexico VL - 49 ER - TY - GEN AU - Organización Mundial de la Salud PY - 2019 TI - Mortalidad materna T2 - Organizacion mundial de la Salud UR - https://www.who.int/maternal_child_adolescent/topics/maternal/maternal_perinatal/es/ ER - TY - GEN AU - Organización Mundial de la Salud KW - adolescencia KW - adolescente KW - adolescente [subject] KW - atención neonatal KW - atención prenatal KW - bajo peso al nacer KW - bienestar materno KW - joven KW - juventud KW - lactante KW - madre KW - maternidad KW - mortalidad materna KW - mortalidad materna [subject] KW - mortalidad neonatal KW - niño KW - niño pequeño KW - parto KW - perinatal KW - recién nacido KW - recién nacido [subject] KW - salud del adolescente [subject] KW - salud del niño [subject] KW - salud del recién nacido KW - salud infantil KW - salud infantil [subject] KW - salud materna [subject] KW - salud neonatal PB - World Health Organization PY - 2017 TI - Salud de la madre, el recién nacido, del niño y del adolescente T2 - WHO UR - http://www.who.int/maternal_child_adolescent/es/ ER - TY - GEN AU - Naciones Unidas DA - 2019/6// PY - 2019 TI - La población mundial sigue en aumento, aunque sea cada vez más vieja T2 - Departamento de Asuntos Económicos y Sociales UR - https://www.un.org/development/desa/es/news/population/world-population-prospects-2019.html ER - TY - BOOK AU - Duque, Maria Claudia AU - Salazar, Edy CY - Bogota PY - 2005 SN - 958-9176-19-4 SP - 448 EP - 448 TI - Cuidado de las personas en los procesos de salud y enfermedad en comunidades indigenas y negras ER - TY - GEN AU - Banco Mundial PY - 2019 TI - Crecimiento de la población (% anual) T2 - Datos banco Mundial UR - https://datos.bancomundial.org/indicator/SP.POP.GROW ER - TY - JOUR AB - BACKGROUND: Expanding access to contraception and ensuring that need for family planning is satisfied are essential for achieving universal access to reproductive healthcare services, as called for in the 2030 Agenda for Sustainable Development. Monitoring progress towards these outcomes is well established for women of reproductive age (15-49 years) who are married or in a union (MWRA). For those who are not, limited data and variability in data sources and indicator definitions make monitoring challenging. To our knowledge, this study is the first to provide data and harmonised estimates that enable monitoring for all women of reproductive age (15-49 years) (WRA), including unmarried women (UWRA). We seek to quantify the gaps that remain in meeting family-planning needs among all WRA. METHODS AND FINDINGS: In a systematic analysis, we compiled a comprehensive dataset of family-planning indicators among WRA from 1,247 nationally representative surveys. We used a Bayesian hierarchical model with country-specific time trends to estimate these indicators, with 95% uncertainty intervals (UIs), for 185 countries. We produced estimates from 1990 to 2019 and projections from 2019 to 2030 of contraceptive prevalence and unmet need for family planning among MWRA, UWRA, and all WRA, taking into account the changing proportions that were married or in a union. The model accounted for differences in the prevalence of sexual activity among UWRA across countries. Among 1.9 billion WRA in 2019, 1.11 billion (95% UI 1.07-1.16) have need for family planning; of those, 842 million (95% UI 800-893) use modern contraception, and 270 million (95% UI 246-301) have unmet need for modern methods. Globally, UWRA represented 15.7% (95% UI 13.4%-19.4%) of all modern contraceptive users and 16.0% (95% UI 12.9%-22.1%) of women with unmet need for modern methods in 2019. The proportion of the need for family planning satisfied by modern methods, Sustainable Development Goals (SDG) indicator 3.7.1, was 75.7% (95% UI 73.2%-78.0%) globally, yet less than half of the need for family planning was met in Middle and Western Africa. Projections to 2030 indicate an increase in the number of women with need for family planning to 1.19 billion (95% UI 1.13-1.26) and in the number of women using modern contraception to 918 million (95% UI 840-1,001). The main limitations of the study are as follows: (i) the uncertainty surrounding estimates for countries with little or no data is large; and (ii) although some adjustments were made, underreporting of contraceptive use and needs is likely, especially among UWRA. CONCLUSIONS: In this study, we observed that large gaps remain in meeting family-planning needs. The projected increase in the number of women with need for family planning will create challenges to expand family-planning services fast enough to fulfil the growing need. Monitoring of family-planning indicators for all women, not just MWRA, is essential for accurately monitoring progress towards universal access to sexual and reproductive healthcare services-including family planning-by 2030 in the SDG era with its emphasis on 'leaving no one behind.' AU - Kantorová, Vladimíra AU - Wheldon, Mark C. AU - Ueffing, Philipp AU - Dasgupta, Aisha N.Z. DA - 2020/2// DO - 10.1371/journal.pmed.1003026 IS - 2 PB - NLM (Medline) PY - 2020 SP - e1003026 EP - e1003026 TI - Estimating progress towards meeting women's contraceptive needs in 185 countries: A Bayesian hierarchical modelling study T2 - PLoS medicine VL - 17 ER - TY - GEN AU - Corte constitucional PY - 1992 TI - Sentencia T-605-92 UR - https://www.corteconstitucional.gov.co/relatoria/1992/T-605-92.htm ER - TY - RPRT AB - El Análisis de Situación de Salud (ASIS) estudia la interacción entre las condiciones de vida y el nivel de los procesos de salud en las diferentes escalas territoriales, políticas y sociales. Se incluye como fundamento el estudio de los grupos poblacionales con diferentes grados de desventaja, consecuencia de la distribución desigual de las condiciones de vida de acuerdo con el sexo, edad y nivel socioeconómico que se desarrollan en ambientes influenciados por el contexto histórico, geográfico, demográfico, social, económico, cultural, político y epidemiológico, en donde se producen relaciones de determinación y condicionamiento1. En este documento se exponen los resultados del análisis de los indicadores seleccionados como trazadores para aportar evidencia efectiva y oportuna que permita hacer uso de la inteligencia sanitaria, en pro del fortalecimiento de la rectoría en salud necesaria para la gobernanza, la planificación y la conducción de políticas públicas en salud. El primer capítulo contiene la caracterización de los contextos territorial, demográfico y político, cada uno constituido por una serie de indicadores que se comportan como determinantes sociales de la salud, que permitieron caracterizar, georreferenciar el territorio e identificar las necesidades sanitarias como insumo para la coordinación intersectorial y transectorial. El segundo capítulo contiene la descripción de los determinantes sociales de la salud poblacional. El tercer capítulo, habla de la composición y organización del Sistema General de Seguridad Social en Salud (SGSSS) AU - Ministerio de salud y protección social PY - 2017 SP - 1 EP - 143 TI - Análisis de situación de salud (ASIS) dirección de epidemiología y demografía T2 - Ministerio de salud UR - https://www.minsalud.gov.co/sites/rid/Lists/BibliotecaDigital/RIDE/VS/ED/PSP/asis-nacional-2017.pdf ER - TY - BOOK AU - Flórez, Carmen Eliza AU - Sánchez, Lina María PY - 2013 SN - 9789588164359 SP - 60 EP - 60 TI - Fecundidad y familia en Colombia: ¿hacia una segunda transición demográfica? VL - 9 ER - TY - RPRT AU - Ministerio de salud y protección social PY - 2019 TI - Análisis de Situación de Salud ( ASIS ) Dirección de Epidemiología y Demografía ER - TY - JOUR AB - Incluye Bibliografía AU - Carmen Elisa Flórez, Leonardo Villar,Nadia Puera, Luisa Berrocal KW - ASPECTOS SOCIALES KW - COMPOSICION FAMILIAR KW - DATOS ESTADISTICOS KW - DEMOGRAPHIC AGEING KW - EMPLEO KW - EMPLOYMENT KW - ENVEJECIMIENTO DE LA POBLACION KW - HOUSEHOLD COMPOSITION KW - SOCIAL ASPECTS KW - STATISTICAL DATA PY - 2017 SP - 3 EP - 66 TI - El proceso de envejecimiento de la población en Colombia T2 - Editorial Fundación Saldarriaga Concha. UR - https://www.repository.fedesarrollo.org.co/bitstream/handle/11445/1021/Repor_Se?sequence=1 ER - TY - GEN AU - Organizacion Mundial de la Salud PY - 2019 TI - Objetivo de Desarrollo del Milenio 5: Mejorar la salud materna T2 - WHO UR - https://www.who.int/maternal_child_adolescent/topics/maternal/mdg/es/ ER - TY - RPRT AB - INTRODUCCIÓN La diversidad cultural es una característica esencial de la humanidad y un fac-tor clave de su desarrollo. Colombia es un país reconocido por su compleja y rica diversidad cultural que se expresa en una gran pluralidad de identidades y de expresiones culturales de los pueblos y comunidades que forman la nación. Como lo plantea la Unesco, la diversidad cultural es una característica esencial de la humanidad, patrimonio común que debe valorarse y preservarse en provecho de todos, pues crea un mundo rico y variado, que acrecienta la gama de posibilidades y nutre las capacidades y los valores humanos, y consti-tuye, por lo tanto, uno de los principales motores del desarrollo sostenible de las comunidades, los pueblos y las naciones. La vitalidad de la cultura colombiana radica precisamente en su diver-sidad, el patrimonio más valioso de la nación. Afrocolombianos, raizales, palenqueros, rom o gitanos, pueblos indígenas, comunidades campesinas, mestizos, y comunidades originadas en migraciones externas enriquecen el mosaico cultural del país. De acuerdo con el censo del año 2005, viven en el territorio nacional 84 pueblos indígenas distribuidos en 704 territorios colec-tivos conocidos como resguardos; existe una población afrodescendiente con una participación superior al 10% de la población nacional y hay más de 150 territorios colectivos de comunidades negras tradicionales en la región del Pa-cífico; igualmente coexisten comunidades rom o gitanas, más de 60 lenguas nativas e innumerables comunidades locales de población campesina. Los an-teriores son sólo algunos referentes básicos de una nación pluriétnica que se construye en la diversidad. COMPENDIO DE POLÍTICAS CULTURALES 372 CONTEXTO En 1991 esta diversidad étnica y cultural fue reconocida en la Constitución Po-lítica de Colombia. Este reconocimiento se ha traducido en normas y políticas y en numerosas acciones institucionales, pero estos esfuerzos son todavía insufi-cientes para crear una cultura de reconocimiento y respeto por la diferencia, y de diálogo y ejercicio de la interculturalidad en la solución de los problemas que conciernen o afectan a los grupos culturalmente diferenciados. Todavía persisten entre la población prejuicios y prácticas de discriminación y exclusión social por razones de pertenencia étnica, género, credo, característi-cas f ísicas y culturales y orientación sexual, entre otros factores. La atención diferencial es uno de los ejes de las políticas culturales; sin em-bargo, se advierten, en el conjunto de la acción pública, dificultades para asumir los retos que ésta demanda. Una de las limitaciones identificadas es la deficiencia en la obtención de información adecuada sobre los grupos social y culturalmente diferenciados. PRINCIPIOS AU - Ministerio de Cultura PY - 2006 SP - 25 EP - 25 TI - Política de diversidad cultural UR - http://www.mincultura.gov.co/ministerio/politicas-culturales/de-diversidad-cultural/Documents/07_politica_diversidad_cultural.pdf ER - TY - BOOK AU - Guerra Curvelo, Weildler. CY - [Bogotá] : PB - Ministerio de Cultura, PY - 2002 SN - 9588159520 SP - 327 EP - 327 TI - La disputa y la palabra : la ley en la sociedad wayuu ER - TY - RPRT AU - Gobernacion de la Guajira PY - 2011 SP - 335 EP - 335 TI - Informe de Gestión para la Garantía de los Derechos de la Infancia, Adolescencia y Juventud ER - TY - RPRT AB - presentacion de resulta dos del pueblo Wayuu AU - DANE PY - 2005 SP - 18 EP - 20 TI - caracterizacion de los pueblos indigenas en Colombia: El pueblo Wayuu T2 - Resultados Del Censo Nacional De PoblacióN Y Vivienda 2005 ER - TY - JOUR AB - Este artículo permite una descripción del origen de los wayuu, así como de su historia a través del tiempo. Se relaciona a la cultura wayuu con el ambiente en el cual viven, y se sigue el análisis de su vivencia hasta nuestros días, viendo su modo cultural de resistencia contra el mundo occidental y el rescate de sus tradiciones. AU - Hostein, Nelly DO - 10.15517/cat.v20i0.2006 IS - 1 KW - cultura wayuu KW - culture wayuu KW - historia wayuu KW - history wayuu KW - origen de los wayuu KW - origin of the wayuu KW - resistance KW - resistencia KW - tradiciones KW - traditions PY - 2010 SP - 8 EP - 8 TI - El pueblo wayuu de la Guajira colombo-venezolana: un panorama de su cultura T2 - Cuadernos de antropología: Revista Digital del Laboratorio de Etnología "María Eugenia Bozzoli Vargas" VL - 20 ER - TY - RPRT AU - Buitrago, Tania PY - 2019 SP - 152 EP - 152 TI - ASIS 2019- Guajira T2 - Minsalud ER - TY - RPRT AB - La Guajira forma una de las principales penínsulas de las Américas. Está dividida en dos regiones; la occidental, es plana o llana; y la oriental, con serranías, cerros aislados y partes llanas. Estas dos regiones están separadas por una línea de fractura, conocida con el nombre de “Cuello de la Guajira”. AU - Ministerio de comercio industria y turismo PY - 2016 SP - 23 EP - 23 TI - La Guajira, Colombia, Guia turística T2 - Boletín de la Sociedad Geográfica de Colombia UR - www.sogeocol.edu.co ER - TY - BOOK AU - Leininger, Madeleine M. AU - Mcfarland, Marilyn R. KW - Cross-Cultural Comparison KW - Cultural Diversity KW - Nursing KW - Philosophy KW - Transcultural Nursing KW - Transcultural nursing PY - 2002 TI - Transcultural Nursing Concepts, Theories, Research and Practice UR - https://philpapers.org/rec/LEITNC ER - TY - JOUR AU - Cunningham Kain, Mirna KW - Aconselhamento KW - Equidade KW - Evolução Cultural KW - Grupos Étnicos KW - Legislação KW - Nicarágua KW - Resoluções KW - Saúde KW - Saúde Pública KW - Seguridade Social PY - 2002 SP - 58 EP - 58 TI - Etnia, Cultura y Salud: la experiencia de la salud intercultural como una herramienta para la equidad en las Regiones Autónomas de Nicaragua ER - TY - GEN AB - El Convenio 169, constituye una pieza clave en la acción de la OIT a favor de la justicia social, objetivo reafirmado en el 2008 con la adopción de la Declaración sobre la justicia social para una globalización equitativa. El Convenio núm. 169 tiene dos postulados básicos: el derecho de los pueblos indígenas a mantener y fortalecer sus culturas, formas de vida e instituciones propias, y su derecho a participar de manera efectiva en las decisiones que les afectan. Estas premisas constituyen la base sobre la cual deben interpretarse las disposiciones del Convenio. AU - Organización Internacional del Trabajo CY - Lima, Peru IS - 9 KW - Convenio de la OIT KW - Declaración de la ONU. KW - Pueblo indígena KW - Resolución de la OIT PY - 2014 SN - 9788578110796 SP - 130 EP - 130 TI - Convenio Núm. 169 de la OIT sobre Pueblos Indígenas y Tribales. Declaración de las Naciones Unidas sobre los Derechos de los Pueblos Indígenas. T2 - Oficina Internacional del Trabajo VL - 53 ER - TY - JOUR AB - This study describes the perceptions and beliefs about pregnancy, delivery, and the post partum period among Mapuche women in the Araucania region. The results demonstrate the existence of a complex system of cultural care for the Mapuche woman in this stage of her life. Social and cultural rules delimit what is allowed during pregnancy and the postpartum period. Among these wefound rigorous feeding rules, the prohibition of participation in certain social events, and the prevention of contact with Mapuche spirits that could harm the pregnant women other child. The cultural pattern of care combines physical, environmental, and spiritual elements of both conventional and Mapuche medicine. For example, maintaining a balance between cold and heat, as well as obeying Mapuche cultural rules, shape women's health behaviours. Knowledge of these cultural patterns of care could contribute to the development of intercultural activities within the woman's health program in our country. © 2009 Universidad de Tarapacá. AU - Alarcón, Ana M. AU - Nahuelcheo S, Yolanda. DO - 10.4067/s0717-73562008000200007 IS - 2 KW - Childbirth KW - Mapuche women KW - Postpartum KW - Pregnancy PY - 2008 SP - 193 EP - 202 TI - Creencias sobre el embarazo, parto y puerperio en la mujer mapuche: Conversaciones privadas T2 - Chungara, Revista de antropolodía chilena VL - 40 ER - TY - GEN AB - Predicting the binding mode of flexible polypeptides to proteins is an important task that falls outside the domain of applicability of most small molecule and protein−protein docking tools. Here, we test the small molecule flexible ligand docking program Glide on a set of 19 non-α-helical peptides and systematically improve pose prediction accuracy by enhancing Glide sampling for flexible polypeptides. In addition, scoring of the poses was improved by post-processing with physics-based implicit solvent MM- GBSA calculations. Using the best RMSD among the top 10 scoring poses as a metric, the success rate (RMSD ≤ 2.0 Å for the interface backbone atoms) increased from 21% with default Glide SP settings to 58% with the enhanced peptide sampling and scoring protocol in the case of redocking to the native protein structure. This approaches the accuracy of the recently developed Rosetta FlexPepDock method (63% success for these 19 peptides) while being over 100 times faster. Cross-docking was performed for a subset of cases where an unbound receptor structure was available, and in that case, 40% of peptides were docked successfully. We analyze the results and find that the optimized polypeptide protocol is most accurate for extended peptides of limited size and number of formal charges, defining a domain of applicability for this approach. AU - Congreso de la República de Colombia IS - diciembre 23 KW - icle PY - 2013 SN - 9788578110796 SP - 1689 EP - 1699 TI - Ley 100 T2 - Journal of Chemical Information and Modeling VL - 53 ER - TY - GEN AB - RESOLUCIÓN ~lite e .F; 429 DE . 2016 HOJA No 2 de 5 Continuación de la resolución "Por medio deja cual se adopta la Politice de Atención Integral en salud" Que para el cumplimiento de este objetivo, el sistema de salud debe encaminar sus esfuerzos al mejoramiento del estado de saly9tcle la población y el goce efectivo del derecho a la salud, para lo cual se hace necesario 'auméhtar el :accesd y el mejoramiento de la calidad de los servicios, fortalecer la infraestructura hospitalaria, recuperar la confianza pública en el sistema de salud y el aseguramiento de la sostenibilidad financiera del sistema y privilegiar estrategias preventivas y de medicina familiar y comunitaria, con enfoque intercultural, complementadas con el fortalecimiento del talento humano en salud, así como la incorporación de estrategias de Telesalud para la población con limitaciones de accesibilidad geográfica. Que en el artículo 65 de la Ley 1753 de 2015 se establece que el Ministerio de Salud y Protección Social —MSPS-, dentro del marco de la Ley 1751 de 2015, Estatutaria en Salud y demás leyes, definirá la política en salud que recibirá la población residente en el territorio colombiano, la cual es de obligatorio cumplimiento para los integrantes del SGSSS y de las demás entidades que tengan a su cargo acciones en salud, bajo el enfoque de Gestión Integral de Riesgo en Salud, para ajustarse a las necesidades territoriales mediante modelos diferenciados para zonas con población urbana, rural y dispersa. Que de conformidad con lo anterior, el MSPS traza la Política de Atención Integral en Salud PAIS, desarrollando un marco estratégico y un modelo operacional que van a permitir la acción coordinada de las normas, reglas, reglamentos, agentes y usuarios, a efectos de orientar la intervención de los diferentes integrantes hacia la generación de las mejores condiciones de la salud de la población y el goce efectivo del derecho fundamental de la salud, al interrelacionar los elementos esenciales que lo configuran. AU - Ministerio de salud y proteccion social PY - 2016 SN - 0011232911200 SP - 2014 EP - 2018 TI - Resolución 429 T2 - Ministerio de Salud y Protección Social, UR - https://www.minsalud.gov.co/Normatividad_Nuevo/Resolución 0429 de 2016.pdf VL - 2015 ER - TY - GEN AB - "Por medio de la cual se modifica la Política de Atención Integral en Salud (PAIS), se adopta el Modelo de Acción Integral Territorial (MAITE) para su implementación." AU - Ministerio de Salud y Protección Social PY - 2019 SP - 1 EP - 17 TI - Resolución 2626 T2 - Ministerio de Salud y Protección Social UR - https://www.minsalud.gov.co/Normatividad_Nuevo/Resolución No. 2626 de 2019.pdf ER - TY - GEN AU - Congreso de colombia PY - 2007 SN - 9781626239777 TI - Ley 1122 ER - TY - GEN AU - Congreso de la republica PY - 2017 SP - 1 EP - 11 TI - Ley 1797 ER - TY - GEN AB - POR MEDIO DE LA CUAL SE REGULA EL DERECHO FUNDAMENTAL A LA SALUD Y SE DICTAN OTRAS DISPOSICIONES. AU - Congreso de la República KW - l PY - 2015 SP - 13 EP - 13 TI - Ley 1751 T2 - Ministerio de Salud y Protección Social UR - https://www.minsalud.gov.co/Normatividad_Nuevo/Ley 1751 de 2015.pdf ER - TY - GEN AU - Congreso de colombia IS - Enero 19 PY - 2011 TI - Ley 1438 VL - 2011 ER - TY - GEN AU - DANE PY - 2019 TI - Demografía y población T2 - Censo poblacional UR - https://www.dane.gov.co/index.php/estadisticas-por-tema/demografia-y-poblacion ER - TY - GEN AB - Por la cual se reglamenta la Contabilidad en general y se expiden los principios o normas de contabilidad generalmente aceptados en colombia. AU - Presidencia de la Republica PY - 2010 SP - 1 EP - 18 TI - Decreto 2716 T2 - Decreto 2716 de 2004 UR - http://www.alcaldiabogota.gov.co/sisjur/normas/Norma1.jsp?i=9863 ER - TY - GEN AU - Presidencia de la republica PY - 2004 TI - Decreto 3183 ER - TY - GEN AB - This study examined weight trajectories in obese patients with binge eating disorder (BED) during the year prior to treatment initiation and explored potential correlates of these weight changes. One hundred thirty (N = 130) consecutive, treatment-seeking, obese patients with BED were assessed with structured interviews and self-report questionnaires. Eighty-three percent (83%; n = 108) of treatment seeking obese BED patients gained weight, and 65% (n = 84) gained a clinically significant amount of weight (greater than or equal to 5% body weight), in the year preceding treatment. Overall, participants reported a mean percent weight gain of 8% (16.6 pounds) during the 12 months prior to treatment with a wide range of weight changes across participants (from a 52% weight gain to a 13% weight loss). A substantial proportion of patients (35%), categorized as High Weight Gainers (defined as gaining more than 10% of body weight during previous year), reported gaining an average of 16.7% of body weight. Low Weight Gainers (defined as gaining greater than 5%, but less than 10%) comprised 29% of the sample and were characterized by a mean gain of 6.9% of body weight. Weight Maintainers/Losers (defined as having maintained or lost weight during the 12 months prior to treatment) comprised 17% of the sample and reported losing on average 2.8% of body weight. These three groups did not differ significantly in their current weight and eating behaviors or eating disorder psychopathology. The majority of treatment-seeking obese patients with BED reported having gained substantial amounts of weight during the previous year. These findings provide an important context for interpreting the modest weight losses typically reported in treatment studies of BED. Failure to produce weight loss in these studies may be reinterpreted as stabilization of weight and prevention of further weight gain. © 2013 Elsevier Inc. All rights reserved. AU - Congreso de colombia PY - 1991 SN - 9789581803866 SP - 1 EP - 50 TI - Ley 21 ER - TY - GEN AB - 1. Justificación Las alteraciones hipertensivas que acompañan al embarazo determinan una compli-cación obstétrica frecuente y de notable morbimortalidad materna y perinatal (1). Es una entidad de prevalencia sostenida, a pesar de los grandes esfuerzos para su control, con la búsqueda de medidas preventivas. El pronóstico es susceptible de modularse mejorando el diagnóstico temprano (2). La incidencia se ha calculado entre el 6 y el 8% de todas las gestaciones y es la primera causa de morbimortalidad materna en nuestro país. En Bogotá constituye la segunda causa de mortalidad materna, después de la hemorragia, donde para el año 2012 de los 41 casos presentados, 5 casos —es decir, el 12,2%— correspondieron a preeclampsia-eclampsia y para el año 2013 de las 24 muer-tes maternas ocurridas, 6 casos —es decir, el 25% de las muertes— correspondieron a trastornos hipertensivos (1). La preeclampsia es la manifestación hipertensiva más frecuente del embarazo, siendo esta una enfermedad de gran complejidad, para la que se requiere un manejo de alto nivel de recurso técnico y humano (3). El diagnóstico de preeclampsia lleva implícita, siempre, la presencia de una disfunción orgánica que conduce a vigilar los criterios de compromiso severo de cada uno de los órganos vitales. Esta condición siempre ha sido considerada la base clínica para entender la alta morbimortalidad del síndrome (2,3). 2. Objetivo general AU - Secretaría Distrital de Salud PY - 2014 SP - 24 EP - 24 TI - Guía de trastornos hipertensivos del embarazo T2 - Secretaría Distrital de Salud Bogotá D.C. UR - http://www.saludcapital.gov.co/DDS/Publicaciones/Guia Maternidad-Trastornos_baja.pdf ER - TY - GEN AB - LEY Nº 691 DE 2001 (Septiembre 18) Reglamentada parcialmente por el Decreto Nacional 2716 de 2004 Mediante la cual se reglamenta la participación de los Grupos Étnicos en el Sistema General de Seguridad Social en Colombia. El Congreso de Colombia DECRETA: CAPITULO I Aplicación, objeto, principios y autoridades Artículo 1o. Aplicación. La presente ley reglamenta y garantiza el derecho de acceso y la participación de los Pueblos Indígenas en los Servicios de Salud, en condiciones dignas y apropiadas, observando el debido respeto y protección a la diversidad étnica y cultural de la nación. En alcance de su aplicación, reglamenta la forma de operación, financiamiento y control del Sistema de Seguridad Social en Salud, aplicable a los Pueblos Indígenas de Colombia, entendiendo por tales la definición dada en el artículo 1o de la Ley 21 de 1991. Artículo 2o. Objeto. La presente ley tiene por objeto proteger de manera efectiva los derechos a la salud de los Pueblos Indígenas, garantizando su integridad cultural de tal manera que se asegure su permanencia social y cultural, según los términos establecidos en la Constitución Política, en los Tratados Internacionales y las demás leyes relativas a los pueblos indígenas. Artículo 3o. De los principios. Para la interpretación y aplicación de la presente ley, además de los principios generales consagrados en la Constitución Política y de los enunciados en la Ley 100 de 1993, es principio aplicable el de la diversidad étnica y cultural; en virtud del cual, el sistema practicará la observancia y el respeto a su estilo de vida y tomará en consideración sus especificidades culturales y ambientales que les permita un desarrollo armónico a los pueblos indígenas. AU - Congreso de colombia PY - 2004 SP - 1 EP - 6 TI - Ley 691 ER - TY - GEN AB - Para los cuidados durante el parto, para una experiencia de parto positiva Transformar la atención a mujeres y neonatos para mejorar su salud y bienestar Resumen de orientación Introducción La mayoría de los aproximadamente 140 millones de nacimientos que ocurren a nivel mundial cada año se dan en mujeres que no presentan factores de riesgo de tener complicaciones para ellas ni para sus bebés, al comienzo y durante el trabajo de parto. Sin embargo, el momento del nacimiento es crítico para la sobrevida de las mujeres y los bebés, ya que el riesgo de morbimortalidad puede aumentar considerablemente si surgen complicaciones. De acuerdo con las metas establecidas en el Objetivo de Desarrollo Sostenible 3: garantizar una vida sana y promover el bienestar para todos en todas las edades, y la nueva Estrategia Mundial para la Salud de la Mujer, el Niño y el Adolescente (2016–2030), la agenda mundial está ampliando su enfoque con el fin de garantizar que las mujeres y los bebés no solo sobrevivan a las complicaciones del parto (si ocurrieran) sino también que se desarrollen y alcancen su potencial de salud y vida. A pesar de los importantes debates e investigaciones que se han desarrollado durante muchos años, el concepto de " normalidad " en el trabajo de parto y el parto no es universal ni está estandarizado. En las últimas dos décadas, se ha producido un aumento considerable en la aplicación de diversas prácticas de trabajo de parto que permiten iniciar, acelerar, terminar, regular o vigilar el proceso fisiológico de dicho proceso con el fin de mejorar los resultados tanto para las mujeres como para los bebés. Esta medicalización creciente de los procesos de parto tiende a debilitar la capacidad de la mujer de dar a luz y afecta de manera negativa su experiencia de parto. Además, el mayor uso de intervenciones en el trabajo de parto sin indicaciones claras continúa ampliando la brecha sanitaria en cuanto a la equidad entre entornos con muchos recursos y aquellos con pocos recursos. AU - Organización Mundial de la Salud PY - 2019 SN - 9789241550215 SP - 210 EP - 210 TI - Cuidados durante el parto para una experiencia de parto positiva T2 - Organización Mundial de la Salud ER - TY - GEN AB - Por la cual se establecen las actividades, procedimientos e intervenciones de demanda inducida y obligatorio cumplimiento y se adoptan las normas técnicas y guías de atención para el desarrollo de las acciones de protección específica y detección temprana y la atención de enfermedades de interés en salud pública AU - Ministerio de salud y proteccion social IS - Febrero 25 PY - 2000 SP - 1 EP - 6 TI - Resolución 412 T2 - Ministerio de Salud UR - http://www.convergenciacnoa.org/images/Documentospdf/legislacion/Resolucion 412.pdf VL - 2000 ER - TY - GEN AU - DANE PY - 2020 TI - Proyecciones de población T2 - DANE UR - https://www.dane.gov.co/index.php/estadisticas-por-tema/demografia-y-poblacion/proyecciones-de-poblacion ER - TY - GEN AU - NAZARETH, E.S.E. HOSPITAL DE PY - 2020 TI - E.S.E Hospital de Nazareth UR - https://esehospitaldenazareth.gov.co/ ER - TY - JOUR AU - Herrera-Castanedo, S AU - Vázquez-Barquero, JL AU - Gaite Pindado, L IS - 6 KW - Medes KW - Medicina en español PY - 2008 SP - 269 EP - 275 TI - La Clasificación Internacional del Funcionamiento, de la Discapacidad y de la Salud (CIF) T2 - Rehabilitación UR - https://medes.com/publication/45346 VL - 42 ER - TY - JOUR AB - Introduction: The problem of inconsistent terminology in functional capacity evaluation (FCE) has been widely addressed in the international literature. Many different terms seem to be used interchangeably while other terms appear to be interpreted differently. This may seriously hinder FCE research and clinical use. To gain consensus in operational definitions in FCE and conceptual framework to classify terminology used in FCE. Methods: A Delphi Survey with FCE experts was conducted which consisted of three rounds of questioning, using semi and full structured questions. The expert group was formed from international experts in FCE. Experts were selected if they met any of the following criteria: at least one international publication as first author and one as co-author in the field of FCE; or an individual who had developed an FCE that was subject of investigation in at least one publication in international literature. Consensus of definitions was considered when 75% or more of all experts agreed with a definition. Results: In total, 22 international experts from 6 different countries in Australia, Europe and North America, working in different health related sectors, participated in this study. Conclusion: Consensus concerning conceptual framework of FCE was met in 9 out of 20 statements. Consensus on definitions was met in 10 out of 19 definitions. Experts agreed to use the ICF as a conceptual framework in which terminology of FCE should be classified and agreed to use pre-defined terms of the ICF. No consensus was reached about the definition of FCE, for which two potential eligible definitions remained. Consensus was reached in many terms used in FCE. For future research, it was recommended that researchers use these terms, use the ICF as a conceptual framework and clearly state which definition for FCE is used because no definition of FCE was consented. © 2008 The Author(s). AU - Soer, Remko AU - Van Der Schans, Cees P. AU - Groothoff, Johan W. AU - Geertzen, Jan H.B. AU - Reneman, Michiel F. DA - 2008/12// DO - 10.1007/s10926-008-9155-y IS - 4 KW - Disability and health KW - Expert based KW - ICF KW - International classification of functioning KW - Work ability PB - J Occup Rehabil PY - 2008 SP - 389 EP - 400 TI - Towards consensus in operational definitions in functional capacity evaluation: A Delphi survey T2 - Journal of Occupational Rehabilitation UR - https://pubmed.ncbi.nlm.nih.gov/19011956/ VL - 18 ER - TY - JOUR AB - Purpose The construct validity of functional capacity evaluations (FCE) in whiplash-associated disorders (WAD) is unknown. The aim of this study was to analyse the validity of FCE in patients with WAD with cultural differences within a workers’ compensation setting. Methods 314 participants (42 % females, mean age 36.7 years) with WAD (grade I and II) were referred for an interdisciplinary assessment that included FCE tests. Four FCE tests (hand grip strength, lifting waist to overhead, overhead working, and repetitive reaching) and a number of concurrent variables such as self-reported pain, capacity, disability, and psychological distress were measured. To test construct validity, 29 a priori formulated hypotheses were tested, 4 related to gender differences, 20 related associations with other constructs, 5 related to cultural differences. Results Men had significantly more hand grip strength (+17.5 kg) and lifted more weight (+3.7 kg): two out of four gender-related hypotheses were confirmed. Correlation between FCE and pain ranged from −0.39 to 0.31; FCE and self-reported capacity from −0.42 to 0.61; FCE and disability from −0.45 to 0.34; FCE and anxiety from −0.36 to 0.27; and FCE and depression from −0.41 to 0.34: 16 of 20 hypotheses regarding FCE and other constructs were confirmed. FCE test results between the cultural groups differed significantly (4 hypotheses confirmed) and effect size (ES) between correlations were small (1 hypothesis confirmed). In total 23 out of 29 hypotheses were confirmed (79 %). Conclusions The construct validity for testing functional capacity was confirmed for the majority of FCE tests in patients with WAD with cultural differences and in a workers’ compensation setting. Additional validation studies in other settings are needed for verification. AU - Trippolini, M. A. AU - Dijkstra, P. U. AU - Geertzen, J. H.B. AU - Reneman, M. F. DA - 2015/9// DO - 10.1007/s10926-014-9555-0 IS - 3 KW - Disability evaluation KW - Lifting KW - Neck pain KW - Population groups KW - Sick leave KW - Whiplash injuries PB - Springer New York LLC PY - 2015 SP - 481 EP - 492 TI - Construct Validity of Functional Capacity Evaluation in Patients with Whiplash-Associated Disorders T2 - Journal of Occupational Rehabilitation UR - https://pubmed.ncbi.nlm.nih.gov/25385201/ VL - 25 ER - TY - JOUR AB - Objectives: Functional Capacity Evaluation methods (FCE) claim to measure the functional physical ability of a person to perform work-related tasks. The purpose of the present study was to systematically review the literature on the reliability and validity of four FCEs: The Blankenship system (BS), the ERGOS work simulator (EWS), the Ergo-Kit (EK) and the Isernhagen work system (IWS). Methods: A syst ematic literature search was conducted in five databases (CINAHL, Medline, Embase, OSH-ROM and Picarta) using the following keywords and their synonyms: Functional capacity evaluation, reliability and validity. The search strategy was performed for relevance in titles and abstracts, and the databases were limited to literature published between 1980 and April 2004. Two independent reviewers applied the inclusion criteria to select all relevant articles and evaluated the methodological quality of all included articles. Results: The search re sulted in 77 potential relevant references but only 12 papers were identified for inclusion and assessed for their methodological quality. The interrater reliability and predictive validity of the IWS were evaluated as good while the procedure used in the intrarater reliability (test-retest) studies was not rigorous enough to allow any conclusion. The concurrent validity of the EWS and EK was not demonstrated while no study was found on their reliability. No study was found on the reliability and validity of the BS. Conclusions: More rigorous studies are needed to demonstrate the reliability and the validity of FCE methods, especially the BS, EWS and EK. © Springer-Verlag 2004. AU - Gouttebarge, Vincent AU - Wind, Haije AU - Kuijer, P. Paul F.M. AU - Frings-Dresen, Monique H.W. DA - 2004/11// DO - 10.1007/s00420-004-0549-7 IS - 8 KW - FCE KW - Functional Capacity Evaluation KW - Reliability KW - Systematic review KW - Validity PB - Int Arch Occup Environ Health PY - 2004 SP - 527 EP - 537 TI - Reliability and validity of Functional Capacity Evaluation methods: A systematic review with reference to Blankenship system, Ergos work simulator, Ergo-Kit and Isernhagen work system T2 - International Archives of Occupational and Environmental Health UR - https://pubmed.ncbi.nlm.nih.gov/15538618/ VL - 77 ER - TY - GEN AU - World Health Organization PY - 2010 TI - Global Strategy on Diet, Physical Activity and Healt T2 - WHO-ICF UR - https://www.who.int/standards/classifications/international-classification-of-functioning-disability-and-health ER - TY - GEN TI - ACSM's guidelines for exercise testing and prescription (Libro, 2018) [WorldCat.org] UR - https://www.worldcat.org/title/acsms-guidelines-for-exercise-testing-and-prescription/oclc/958942491 ER - TY - GEN AB - Background in 2010, the European Working Group on Sarcopenia in Older People (EWGSOP) published a sarcopenia definition that aimed to foster advances in identifying and caring for people with sarcopenia. In early 2018, the Working Group met again (EWGSOP2) to update the original definition in order to reflect scientific and clinical evidence that has built over the last decade. This paper presents our updated findings. Objectives to increase consistency of research design, clinical diagnoses and ultimately, care for people with sarcopenia. Recommendations sarcopenia is a muscle disease (muscle failure) rooted in adverse muscle changes that accrue across a lifetime; sarcopenia is common among adults of older age but can also occur earlier in life. In this updated consensus paper on sarcopenia, EWGSOP2: (1) focuses on low muscle strength as a key characteristic of sarcopenia, uses detection of low muscle quantity and quality to confirm the sarcopenia diagnosis, and identifies poor physical performance as indicative of severe sarcopenia; (2) updates the clinical algorithm that can be used for sarcopenia case-finding, diagnosis and confirmation, and severity determination and (3) provides clear cut-off points for measurements of variables that identify and characterise sarcopenia. Conclusions EWGSOP2's updated recommendations aim to increase awareness of sarcopenia and its risk. With these new recommendations, EWGSOP2 calls for healthcare professionals who treat patients at risk for sarcopenia to take actions that will promote early detection and treatment. We also encourage more research in the field of sarcopenia in order to prevent or delay adverse health outcomes that incur a heavy burden for patients and healthcare systems. AU - Cruz-Jentoft, Alfonso J. AU - Bahat, Gülistan AU - Bauer, Jürgen AU - Boirie, Yves AU - Bruyère, Olivier AU - Cederholm, Tommy AU - Cooper, Cyrus AU - Landi, Francesco AU - Rolland, Yves AU - Sayer, Avan Aihie AU - Schneider, Stéphane M. AU - Sieber, Cornel C. AU - Topinkova, Eva AU - Vandewoude, Maurits AU - Visser, Marjolein AU - Zamboni, Mauro AU - Bautmans, Ivan AU - Baeyens, Jean Pierre AU - Cesari, Matteo AU - Cherubini, Antonio AU - Kanis, John AU - Maggio, Marcello AU - Martin, Finbarr AU - Michel, Jean Pierre AU - Pitkala, Kaisu AU - Reginster, Jean Yves AU - Rizzoli, René AU - Sánchez-Rodríguez, Dolores AU - Schols, Jos DA - 2019/1// DO - 10.1093/ageing/afy169 IS - 1 KW - EWGSOP2 KW - muscle assessment KW - muscle strength KW - older people KW - physical performance KW - sarcopenia PB - Oxford University Press PY - 2019 SP - 16 EP - 31 TI - Sarcopenia: Revised European consensus on definition and diagnosis T2 - Age and Ageing UR - https://pubmed.ncbi.nlm.nih.gov/30312372/ VL - 48 ER - TY - JOUR AB - Muscle mass decreases with age, leading to 'sarcopenia,' or low relative muscle mass, in elderly people. Sarcopenia is believed to be associated with metabolic, physiologic, and functional impairments and disability. Methods of estimating the prevalence of sarcopenia and its associated risks in elderly populations are lacking. Data from a population-based survey of 883 elderly Hispanic and non-Hispanic white men and women living in New Mexico (the New Mexico Elder Health Survey, 1993-1995) were analyzed to develop a method for estimating the prevalence of sarcopenia. An anthropometric equation for predicting appendicular skeletal muscle mass was developed from a random subsample (n = 199) of participants and was extended to the total sample. Sarcopenia was defined as appendicular skeletal muscle mass (kg)/height2 (m2) being less than two standard deviations below the mean of a young reference group. Prevalences increased from 13-24% in persons under 70 years of age to >50% in persons over 80 years of age, and were slightly greater in Hispanics than in non-Hispanic whites. Sarcopenia was significantly associated with self-reported physical disability in both men and women, independent of ethnicity, age, morbidity, obesity, income, and health behaviors. This study provides some of the first estimates of the extent of the public health problem posed by sarcopenia. AU - Baumgartner, Richard N. AU - Koehler, Kathleen M. AU - Gallagher, Dympna AU - Romero, Linda AU - Heymsfield, Steven B. AU - Ross, Robert R. AU - Garry, Philip J. AU - Lindeman, Robert D. DA - 1998/4// DO - 10.1093/oxfordjournals.aje.a009520 IS - 8 KW - Aged KW - Aging KW - Body composition KW - Body mass index KW - Frail elderly KW - Muscles PB - Oxford University Press PY - 1998 SP - 755 EP - 763 TI - Epidemiology of sarcopenia among the elderly in New Mexico T2 - American Journal of Epidemiology UR - https://pubmed.ncbi.nlm.nih.gov/9554417/ VL - 147 ER - TY - JOUR AB - OBJECTIVES: To compare two sarcopenia definitions and examine the relationship between them and lower extremity function and other health related factors using data from the baseline examination of the Health Aging and Body Composition (Health ABC) Study. DESIGN: Observational cohort study. SETTING: Two U.S. communities in Memphis, Tennessee, and Pittsburgh, Pennsylvania. PARTICIPANTS: Participants were aged 70 to 79 (N = 2,984, 52% women, 41% black). MEASUREMENTS: Participants were assessed using dual energy x-ray absorptiometry and were classified as sarcopenic using two different approaches to adjust lean mass for body size: appendicular lean mass divided by height-squared (aLM/ht2) and appendicular lean mass adjusted for height and body fat mass (residuals). RESULTS: These methods differed substantially in the classification of individuals as being sarcopenic, especially those who were more obese. The former method was highly correlated with body mass index and identified fewer overweight or obese individuals as sarcopenic. In both men and women, none of the obese group would be considered sarcopenic using the aLM/ht2 method, compared with 11.5% of men and 21.0% of women using the residuals method. In men, both classifications of sarcopenia were associated with smoking, poorer health, lower activity, and impaired lower extremity function. Fewer associations with health factors were noted in women, but the classification based on both height and fat mass was more strongly associated with lower extremity functional limitations (odds ratio (OR)= 0.9, 95% confidence interval (CI) = 0.7-1.2 for low kg/ht 2; OR= 1.9, 95% CI = 1.4-2.5 for lean mass adjusted for height and fat mass). CONCLUSION: These findings suggest that fat mass should be considered in estimating prevalence of sarcopenia in women and in overweight or obese individuals. AU - Newman, Anne B. AU - Kupelian, Varant AU - Visser, Marjolein AU - Simonsick, Eleanor AU - Goodpaster, Bret AU - Nevitt, Michael AU - Kritchevsky, Stephen B. AU - Tylavsky, Frances A. AU - Rubin, Susan M. AU - Harris, Tamara B. DA - 2003/11// DO - 10.1046/j.1532-5415.2003.51534.x IS - 11 KW - Muscle mass KW - Physical function KW - Sarcopenia PB - J Am Geriatr Soc PY - 2003 SP - 1602 EP - 1609 TI - Sarcopenia: Alternative Definitions and Associations with Lower Extremity Function T2 - Journal of the American Geriatrics Society UR - https://pubmed.ncbi.nlm.nih.gov/14687390/ VL - 51 ER - TY - GEN AB - The purpose of this study was to determine skeletal muscle cutpoints for identifying elevated physical disability risk in older adults. Subjects included 4,449 older (≥60 years) participants from the Third National Health and Nutrition Examination Survey during 1988-1994. Physical disability was assessed by questionnaire, and bioimpedance was used to estimate skeletal muscle, which was normalized for height. Receiver operating characteristics were used to develop the skeletal muscle cutpoints associated with a high likelihood of physical disability. Odds for physical disability were compared in subjects whose measures fell above and below these cutpoints. Skeletal muscle cutpoints of 5.76-6.75 and ≤5.75 kg/m2 were selected to denote moderate and high physical disability risk in women. The corresponding values in men were 8.51-10,75 and ≤8.50 kg/m2. Compared with women with low-risk skeletal muscle values, women with moderate- and high-risk skeletal muscle values had odds for physical disability of 1.41 (95% confidence interval (CI): 0.97, 2.04) and 3.31 (95% CI: 1.91, 5.73), respectively. The corresponding odds in men were 3.65 (95% CI: 1.92, 6,94) and 4.71 (95% CI: 2.28, 9.74). This study presents skeletal muscle cutpoints for physical disability risk in older adults. Future applications of these cutpoints include the comparison of morbidity risk in older persons with normal muscle mass and those with sarcopenia, the determination and comparison of sarcopenia prevalences, and the estimation of health-care costs attributable to sarcopenia. AU - Janssen, Ian AU - Baumgartner, Richard N. AU - Ross, Robert AU - Rosenberg, Irwin H. AU - Roubenoff, Ronenn DA - 2004/2// DO - 10.1093/aje/kwh058 IS - 4 KW - Activities of daily living KW - Aging KW - Disability evaluation KW - Men KW - Muscle, skeletal KW - Risk KW - Women PB - Am J Epidemiol PY - 2004 SP - 413 EP - 421 TI - Skeletal Muscle Cutpoints Associated with Elevated Physical Disability Risk in Older Men and Women T2 - American Journal of Epidemiology UR - https://pubmed.ncbi.nlm.nih.gov/14769646/ VL - 159 ER - TY - JOUR AB - OBJECTIVES: To establish the prevalence of sarcopenia in older Americans and to test the hypothesis that sarcopenia is related to functional impairment and physical disability in older persons. DESIGN: Cross-sectional survey. SETTING: Nationally representative cross-sectional survey using data from the Third National Health and Nutrition Examination Survey (NHANES III). PARTICIPANTS: Fourteen thousand eight hundred eighteen adult NHANES III participants aged 18 and older. MEASUREMENTS: The presence of sarcopenia and the relationship between sarcopenia and functional impairment and disability were examined in 4,504 adults aged 60 and older. Skeletal muscle mass was estimated from bioimpedance analysis measurements and expressed as skeletal muscle mass index (SMI = skeletal muscle mass/body mass × 100). Subjects were considered to have a normal SMI if their SMI was greater than -one standard deviation above the sex-specific mean for young adults (aged 18-39). Class I sarcopenia was considered present in subjects whose SMI was within -one to -two standard deviations of young adult values, and class II sarcopenia was present in subjects whose SMI was below -two standard deviations of young adult values. RESULTS: The prevalence of class I and class II sarcopenia increased from the third to sixth decades but remained relatively constant thereafter. The prevalence of class I (59% vs 45%) and class II (10% vs 7%) sarcopenia was greater in the older (≥ 60 years) women than in the older men (P <.001). The likelihood of functional impairment and disability was approximately two times greater in the older men and three times greater in the older women with class II sarcopenia than in the older men and women with a normal SMI, respectively. Some of the associations between class II sarcopenia and functional impairment remained significant after adjustment for age, race, body mass index, health behaviors, and comorbidity. CONCLUSIONS: Reduced relative skeletal muscle mass in older Americans is a common occurrence that is significantly and independently associated with functional impairment and disability, particularly in older women. These observations provide strong support for the prevailing view that sarcopenia may be an important and potentially reversible cause of morbidity and mortality in older persons. AU - Janssen, Ian AU - Heymsfield, Steven B. AU - Ross, Robert DO - 10.1046/j.1532-5415.2002.50216.x IS - 5 KW - Aging KW - Disability KW - Functional impairment KW - NHANES III KW - Prevalence KW - Sarcopenia KW - Skeletal muscle PB - J Am Geriatr Soc PY - 2002 SP - 889 EP - 896 TI - Low relative skeletal muscle mass (sarcopenia) in older persons is associated with functional impairment and physical disability T2 - Journal of the American Geriatrics Society UR - https://pubmed.ncbi.nlm.nih.gov/12028177/ VL - 50 ER - TY - CONF AB - In studies on work it is important to assess various subjective symptoms, complaints, and annoyances. To measure such symptoms, psychophysical ratio scales may be used, as along with simpler category rating scales. In this paper some of the basic concepts and methods of psychophysics have been described. In the field of heavy physical work and the perception of effort and exertion, one of the most popular methods is the rating of perceived exertion. This scale has been presented toghether with a new category ratio scale, commonly referred to as the CR-10 scale. Some situations in which it is important to obtain measurements of perceived exertion have also been described in the paper. AU - Borg, G. DO - 10.5271/sjweh.1815 IS - SUPPL. 1 KW - physical effort KW - psychophysics KW - rating of perceived exertion KW - ratings of exertion KW - scales KW - subjective symptoms KW - work load PY - 1990 SP - 55 EP - 58 TI - Psychophysical scaling with applications in physical work and the perception of exertion T2 - Scandinavian Journal of Work, Environment and Health VL - 16 ER - TY - JOUR AB - In the present article, three scales developed by Borg are compared on bicycle ergometer work. In the first study, comparing the Borg Ratings of Perceived Exertion (RPE) and Category scales with Ratio properties (CR10) scales, 40 healthy subjects (12 men and eight women for each scale) with a mean age of about 30 years (SD≈6) participated. A work-test protocol with step-wise increase of work loads every minute was used (20 W increase for men and 15 W for women). Ratings and heart rates (HRs) were recorded every minute and blood lactates every third minute. Data obtained with the RPE scale were described with linear regressions, with individual correlations of about 0.98. Data obtained with the CR10 scale could also be described by linear regressions, but when described by power functions gave exponents of about 1.2 (SD≈0.4) (with one additional constant included in the power function). This was significantly lower than the exponent of between 1.5 and 1.9 that has previously been observed. Mean individual correlations were 0.98. Blood lactate concentration grew with monotonously increasing functions that could be described by power functions with a mean exponent of about 2.6 (SD≈0.6) (with two additional constants included in the power functions). In the second study, where also the more recently developed Borg CR100 scale (centiMax) was included, 24 healthy subjects (12 men and 12 women) with a mean age of about 29 years (SD≈3) participated in a work test with a step-wise increase of work loads (25 W) every third minute. Ratings and HRs were recorded. RPE values were described by linear regressions with individual correlations of about 0.97. Data from the two CR scales were described by power functions with mean exponents of about 1.4 (SD≈0.5) (with a-values in the power functions). Mean individual correlations were about 0.98. In both studies, a tendency for a deviation from linearity between RPE values and HRs was observed. The obtained deviations from what has previously been obtained for work of longer duration (4-6 min) points to a need for standardization of work-test protocols and to the advantage of using CR scales. Copyright © Blackwell Munksgaard 2005. AU - Borg, E. AU - Kaijser, L. DA - 2006/2// DO - 10.1111/j.1600-0838.2005.00448.x IS - 1 KW - Borg scale KW - Category Ratio KW - Exercise tests KW - Growth function PB - Scand J Med Sci Sports PY - 2006 SP - 57 EP - 69 TI - A comparison between three rating scales for perceived exertion and two different work tests T2 - Scandinavian Journal of Medicine and Science in Sports UR - https://pubmed.ncbi.nlm.nih.gov/16430682/ VL - 16 ER - TY - JOUR AB - In critically ill patients, pain is frequently underestimated and so insufficiently managed. Psychological, haemodynamic and neuroendocrine responses, secondary to untreated pain, could produce morbidity and even increases in patient mortality. All members of the intensive care team must have abilities to assess and to manage pain. The evaluation of pain in the critically ill patient is very difficult but extremely important. Self-reported pain is the starting point for treatment. The pain scores recommended are, VAS (visual analogue scale) and NRS (numeric rating scale) in communicative patients and Campbell scale in uncommunicative patients. Adequate and regular patient assessment leads to improved pain control. Scores higher than 3 points should not be permitted. A pain-free Intensive Care Unit should be a quality standard healthcare aim. AU - Pardo, C. AU - Muñoz, T. AU - Chamorro Jambrina, C. DA - 2008/2// DO - 10.1016/s0210-5691(06)74552-1 KW - Intensive care KW - Monitoring KW - Pain KW - Scales PB - Med Intensiva PY - 2008 SP - 38 EP - 44 TI - Monitorización del dolor. Recomendaciones del grupo de trabajo de analgesia y sedación de la SEMICYUC T2 - Journal of Medicine and Science in Sports UR - https://pubmed.ncbi.nlm.nih.gov/17129536/ ER - TY - JOUR AU - Sinaki, M AU - Offord, K P PY - 1988 SP - 277 EP - 280 TI - Physical activity in postmenopausal women: effect on back muscle strength and bone mineral density of the spine T2 - Archives of physical medicine and rehabilitation UR - https://pubmed.ncbi.nlm.nih.gov/3258510/ ER - TY - JOUR AB - Knee extension strength (KES) improves following body mass-based lower body exercise training; however, it is unknown whether this type of exercise increases handgrip strength (HGS) as a result of a cross-education effect in older individuals. Our aim was to investigate the effect of a body mass-based exercise intervention on HGS and KES in older adults. At baseline, 166 subjects started a 12-week intervention program, and 160 (108 women and 52 men) subjects completed the study. A self-selected group of 37 older adults (21 women and 16 men) served as a control group. HGS, KES, and ultrasound-derived anterior thigh muscle thickness (anterior thigh MT) were measured at baseline and post-testing, and relative strength of the knee extensor (KES/anterior thigh MT) was calculated. A linear regression model controlling for baseline values of body-mass index, % body fat, fat-free mass, HGS, chair stand time, anterior thigh MT, and KES/body mass ratio found a significant difference between control and training groups for KES post-testing values (p = 0.001) and anterior thigh MT post-testing values (p = 0.012), but not for HGS post-testing values (p = 0.287). Our results suggest that increases in lower body strength and muscle size following a 12-week lower body mass-based exercise intervention fail to translate into improvements in HGS. AU - Yaginuma, Yu AU - Abe, Takashi AU - Thiebaud, Robert S. AU - Kitamura, Takahiro AU - Kawanishi, Masashi AU - Fukunaga, Tetsuo DA - 2017/5// DO - 10.1089/biores.2017.0008 IS - 1 KW - Cross education KW - Exercise intensity KW - Maximum isometric strength KW - Muscle thickness PB - Mary Ann Liebert Inc. PY - 2017 SP - 19 EP - 27 TI - Can Handgrip Strength Improve Following Body Mass-Based Lower Body Exercise? T2 - BioResearch Open Access UR - /pmc/articles/PMC5385419/ UR - /pmc/articles/PMC5385419/?report=abstract UR - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5385419/ VL - 6 ER - TY - JOUR AB - Introduction: Gait speed is a test to measure functional capacity in older adults. Nevertheless, the factors influencing this variable are not well described in South American populations. Objective: To determine the relationship between usual and maximal walking speed and functional parameters among Chilean community-dwelling older adults. Materials and methods: An observational, descriptive and cross-sectional study including 69 older adults was conducted. The usual and maximal gait speeds were associated with body composition (body mass index), upper limbs muscle strength (arm curl-ups), lower limbs muscle strength (30 seconds sit-to-stand test), global function (Barthel index), ankle flexibility (range of motion), dynamic balance (timed Up & Go test) and aerobic capacity (2 minutes walking test). Results: The ankle flexibility, lower limbs strength and aerobic capacity influenced the maximal speed (R2=0.65; p <0.001), while the usual speed was influenced by upper limbs and lower limbs strength and by the aerobic capacity (R2= 0.51; p <0.001). Conclusion: The usual and maximal gait speeds are mostly influenced by the lower limbs muscle strength plus aerobic capacity. AU - Rybertt, Christopher AU - Cuevas, Silvia AU - Winkler, Ximena AU - Lavados, Pamela AU - Martínez, Sergio Francisco DA - 2015/6// DO - 10.7705/biomedica.v35i2.2571 IS - 2 KW - Aging KW - Gait KW - Mobility limitations KW - Physical examination KW - Physical fitness PB - Instituto Nacional de Salud PY - 2015 SP - 212 EP - 218 TI - Parámetros funcionales y su relación con la velocidad de marcha en adultos mayores chilenos residentes en la comunidad T2 - Biomedica UR - https://revistabiomedica.org/index.php/biomedica/article/view/2571/2822 UR - https://revistabiomedica.org/index.php/biomedica/article/view/2571 VL - 35 ER - TY - JOUR TI - Avaliação e prescrição para prevenção e reabilitação UR - https://www.scielo.br/scielo.php?script=sci_nlinks&ref=000076&pid=S1517-8692200700050000700003&lng=en ER - TY - JOUR AU - Puthoff, Michael L DA - 2008/3// IS - 1 PB - Cardiopulmonary Physical Therapy Section of the American Physical Therapy Association PY - 2008 SP - 17 EP - 22 TI - Outcome measures in cardiopulmonary physical therapy: short physical performance battery. T2 - Cardiopulmonary physical therapy journal UR - http://www.ncbi.nlm.nih.gov/pubmed/20467494 UR - http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=PMC2845214 VL - 19 ER - TY - JOUR AU - Hernandez, Nicolas AU - Alvarez, Guillermo AU - Bravo, Franklyn AU - Vieira, José Carlo AU - Reina, Eduardo Antonio AU - Herrera, Juan manuel PY - 2018 TI - Validación de la prueba de Romberg Modificada para la determinación del tiempo de propiocepción inconciente en adultos sanos T2 - Rev Colomb Ortop Traumatol UR - https://www.researchgate.net/figure/Figura-1-Prueba-de-Romberg-modificada_fig1_323108327 ER - TY - JOUR AU - Franca da Silva, Anne Kastelianne AU - da Costa de Rezende Barbosa, Marianne Penachini AU - Barbosa Bernardo, Aline Fernanda PY - 2014 SP - 255 EP - 265 TI - Cardiac risk stratification in cardiac rehabilitation programs: a review of protocols T2 - Rev Bras Cir Cardiovasc UR - https://pubmed.ncbi.nlm.nih.gov/25140477/ ER - TY - GEN AU - Inc QS TI - Calculate by QxMD | QxMD UR - https://qxmd.com/calculate-by-qxmd ER - TY - JOUR AU - Karvonen, M J AU - Kentala, E AU - Mustala, O PY - 1957 SP - 307 EP - 315 TI - The effects of training on heart rate; a longitudinal study T2 - Ann Med Exp Biol Fenn UR - https://pubmed.ncbi.nlm.nih.gov/13470504/ ER - TY - GEN AU - World Health Organization KW - cancer [subject] KW - cervical cancer KW - diet [subject] KW - exercise KW - health risks KW - healthy diet KW - movement KW - physical activity [subject] KW - risk KW - risk factor [subject] PB - World Health Organization PY - 2001 TI - International Classification of Functioning, Disability and Health - WHO-ICF T2 - WHO-ICF UR - http://www.who.int/nmh/wha/59/dpas/en/ ER - TY - JOUR AU - Pollock, M.L. AU - Wilmore, J PY - 1996 SP - 1 EP - 9 TI - Resistance training for Health. The President’s Council on Physical Fitness and Sports Research Digest UR - https://www.scirp.org/(S(351jmbntvnsjt1aadkposzje))/reference/ReferencesPapers.aspx?ReferenceID=1010870 ER - TY - JOUR AB - [Purpose] The trunk muscles frequently become weak after stroke, thus impacting overall activities of daily living. However, activities of daily living items closely related with trunk strength remain unclear. This study aimed to clarify the influence of trunk muscle weakness on activities of daily living items. [Subjects] The subjects were 24 stroke patients who fulfilled the following inclusion criteria: first stroke and the absence of severe paralysis, marked cognitive function deterioration, unilateral spatial neglect or apathy. [Methods] According to abdominal strength, the 24 patients were divided into a nonweakness group and a weakness group. For the assessment, we used the stroke impairment assessment set, the Berg balance scale, a simple test for evaluating hand function, grip strength, and functional independence measure scale scores and the results were compared between the groups. [Results] The Berg balance scale score and scores for dressing, toilet use, transfer to bed, and walk items of the functional independence measure were significantly lower in the weakness group than in the nonweakness group. [Conclusion] Our results suggest that weakness of the abdominal muscles adversely impacts the balance of patients with mild stroke as well as their ability to dress, use a toilet, transfer, and walk. Trunk training, including abdominal muscle exercises, can effectively improve the performance of these activities of daily living items. AU - Fujita, Takaaki AU - Sato, Atsushi AU - Togashi, Yui AU - Kasahara, Ryuichi AU - Ohashi, Takuro AU - Yamamoto, Yuichi DA - 2015/3// DO - 10.1589/jpts.27.815 IS - 3 KW - Abdominal muscles KW - Activities of daily living KW - Stroke PB - Society of Physical Therapy Science (Rigaku Ryoho Kagakugakkai) PY - 2015 SP - 815 EP - 818 TI - Contribution of abdominal muscle strength to various activities of daily living of stroke patients with mild paralysis T2 - Journal of Physical Therapy Science UR - https://pubmed.ncbi.nlm.nih.gov/25931737/ VL - 27 ER - TY - JOUR AB - [Purpose] The purpose of this study was to provide basic information as reference and guidelines for the implementation of abdominal muscle exercise programs for people with intellectual disabilities residing in residential care facilities. [Subjects and Methods] The study period was 12 weeks, from July 1, 2015, to September 30, 2015. The study participants comprised of 10 people with intellectual disabilities who were residing in a residential care facility. An occupational therapist measured each subject’s weight and physical fitness (muscle strength and flex-ibility). Collected data were encoded by using items and analyzed using SPSS ver.18.0. [Results] Weight decreased significantly, and physical fitness (muscle strength and flexibility) increased significantly. [Conclusion] To actively improve abdominal muscle strength and health management in people with intellectual disabilities residing in residential care facilities, consistent implementation of abdominal muscle exercise programs and improvements are indispensable, as these could lead to the development of systematic programs for rehabilitation physical activities. AU - Son, Sungmin AU - Jeon, Byoungjin DO - 10.1589/jpts.29.1196 IS - 7 KW - Abdominal muscle exercise KW - People with intellectual disability KW - Residential care facility PB - Society of Physical Therapy Science (Rigaku Ryoho Kagakugakkai) PY - 2017 SP - 1196 EP - 1200 TI - Effects of an abdominal muscle exercise program in people with intellectual disabilities residing in a residential care facility T2 - Journal of Physical Therapy Science UR - /pmc/articles/PMC5509590/ UR - /pmc/articles/PMC5509590/?report=abstract UR - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5509590/ VL - 29 ER - TY - JOUR AB - The aim of this study was to evaluate the timed sit-to-stand (STS) test performances of healthy young adults and to investigate the relationship of timed STS tests with 6-minute walk test (6MWT). A cross-sectional study was performed. A total of 40 healthy volunteers (mean age: 21.7 ± 1.2 years) were evaluated with 10, 30, and 60 seconds STS tests and 6MWT. Fatigue and shortness of breath were rated using Borg category-ratio scale (CR10) before and after each test. Weekly energy expenditures of volunteers were calculated using International Physical Activity Questionnaire. 30 and 60 seconds STS tests were moderately (r = 0.611 and r = 0.647, respectively) (P < .001) and 10 seconds STS test was weakly (r = 0.344) (P = .028) correlated with 6MWT. Among correlations of each STS test with 6MWT, none of them was statistically stronger to one another (P > .05). Borg fatigue scores after 10, 30, and 60 seconds STS tests were weakly correlated with fatigue score after 6MWT (r = 0.321, r = 0.378, and r = 0.405, respectively) (P < .05). Weekly energy expenditure (MET-min/week) was moderately correlated with 10, 30, and 60 seconds STS tests and 6MWT (r = 0.533, r = 0.598, r = 0.598, and r = 0.547, respectively) (P < .001). Considering the statistically significant relationship between timed STS tests and 6MWT, any of the timed STS tests may be used for a quick and alternative measurement of physical performance and functional capacity in healthy young adults. AU - Gurses, Hulya Nilgun AU - Zeren, Melih AU - Denizoglu Kulli, Hilal AU - Durgut, Elif DA - 2018/1// DO - 10.1097/MD.0000000000009489 IS - 1 KW - 6-minute walk test KW - functional capacity KW - physical activity KW - sit-to-stand test KW - young adults PB - Lippincott Williams and Wilkins PY - 2018 TI - The relationship of sit-to-stand tests with 6-minute walk test in healthy young adults T2 - Medicine (United States) UR - https://pubmed.ncbi.nlm.nih.gov/29505521/ VL - 97 ER - TY - JOUR AB - Aim: To examine the relationship between cardiorespiratory fitness (CRF) and risk of incident heart failure (HF). Methods Cardiorespiratory fitness, as measured by maximal oxygen uptake (VO2max), was assessed at baseline in a prospective and results: cohort of 1873 men aged 42-61 years without HF or chronic respiratory disease. During a mean follow-up of 20.4 years, 152 incident HF events were recorded. Within-person variability was calculated using data from repeat measurements taken 11 years apart. The age-adjusted hazard ratio (HR) per unit increase (1 mL/kg/min of VO2max) in CRF was 0.89 [95% confidence interval (CI) 0.86-0.93], which was minimally attenuated to 0.94 (95% CI 0.90-0.98) after further adjustment for established HF risk factors (body mass index, systolic blood pressure, history of cardiovascular disease, diabetes, heart rate, and LV hypertrophy) and incident coronary events as a timevarying covariate. In a comparison of extreme quartiles of CRF levels (VO2max ≥35.4 vs. ≤25.7 mL/kg/min), the corresponding HRs were 0.27 (0.15-0.50) and 0.48 (0.25-0.92), respectively. Each 1 MET (metabolic equivalent of oxygen consumption) increment in CRF was associated with a 21% (7-33%) reduction in multivariable adjusted risk of HF. Addition of CRF to a HF risk prediction model containing established risk factors did not significantly improve risk discrimination (C-index change = 0.0164, P = 0.07). Conclusions: In this Finnish population, there is a strong, inverse, and independent association between long-term CRF and HF risk, consistent with a dose-response relationship. The protective effect of CRF on HF risk warrants further evaluation. © 2013 European Society of Cardiology. AU - Khan, Hassan AU - Kunutsor, Setor AU - Rauramaa, Rainer AU - Savonen, Kai AU - Kalogeropoulos, Andreas P. AU - Georgiopoulou, Vasiliki V. AU - Butler, Javed AU - Laukkanen, Jari A. DO - 10.1111/ejhf.37 IS - 2 KW - Cardiorespiratory fitness KW - Heart failure KW - Maximal oxygen uptake KW - Risk prediction PB - Oxford University Press PY - 2014 SP - 180 EP - 188 TI - Cardiorespiratory fitness and risk of heart failure: A population-based follow-up study T2 - European Journal of Heart Failure UR - https://pubmed.ncbi.nlm.nih.gov/24464981/ VL - 16 ER - TY - JOUR AB - Background-Multiple studies have demonstrated strong associations between cardiorespiratory fitness and lower cardiovascular disease mortality. In contrast, little is known about associations of fitness with nonfatal cardiovascular events. Methods and Results-Linking individual participant data from the Cooper Center Longitudinal Study with Medicare claims files, we studied 20 642 participants (21% women) with fitness measured at the mean age of 49 years and who survived to receive Medicare coverage from 1999 to 2009. Fitness was categorized into age- and sex-specific quintiles (Q) according to Balke protocol treadmill time with Q1 as low fitness. Fitness was also estimated in metabolic equivalents according to treadmill time. Associations between midlife fitness and hospitalizations for heart failure and acute myocardial infarction after the age of 65 years were assessed by applying a proportional hazards model to the multivariate failure time data. After 133 514 person-years of Medicare follow-up, we observed 1051 hospitalizations for heart failure and 832 hospitalizations for acute myocardial infarction. Compared with high fitness (Q4-5), low fitness (Q1) was associated with a higher rate of heart failure hospitalization (14.3% versus 4.2%) and hospitalization for myocardial infarction (9.7% versus 4.5%). After multivariable adjustment for baseline age, blood pressure, diabetes mellitus, body mass index, smoking status, and total cholesterol, a 1 unit greater fitness level in metabolic equivalents achieved in midlife was associated with ≈20% lower risk for heart failure hospitalization after the age of 65 years (men: hazard ratio [95% confidence intervals], 0.79 [0.75-0.83]; P<0.001 and women: 0.81 [0.68-0.96]; P=0.01) but just a 10% lower risk for acute myocardial infarction in men (0.91 [0.87-0.95]; P<0.001) and no association in women (0.97 [0.83-1.13]; P=0.68). Conclusions-Fitness in healthy, middle-aged adults is more strongly associated with heart failure hospitalization than acute myocardial infarction outcomes decades later in older age. © 2013 American Heart Association, Inc. AU - Berry, Jarett D. AU - Pandey, Ambarish AU - Gao, Ang AU - Leonard, David AU - Farzaneh-Far, Ramin AU - Ayers, Colby AU - DeFina, Laura AU - Willis, Benjamin DA - 2013/7// DO - 10.1161/CIRCHEARTFAILURE.112.000054 IS - 4 KW - Heart failure KW - Myocardial infarction KW - Physical fitness PB - Circ Heart Fail PY - 2013 SP - 627 EP - 634 TI - Physical fitness and risk for heart failure and coronary artery disease T2 - Circulation: Heart Failure UR - https://pubmed.ncbi.nlm.nih.gov/23677924/ VL - 6 ER - TY - JOUR AB - High-Intensity Functional Training (HIFT) is a novel exercise intervention that may test body systems in a balanced and integrated fashion by challenging individuals’ abilities to complete mechanical work. However, research has not previously determined if physical work capacity is unique to traditional physiologic measures of fitness. Twenty-five healthy men and women completed a six-week HIFT intervention with physical work capacity and various physiologic measures of fitness assessed pre- and post-intervention. At baseline, these physiologic measures of fitness (e.g., aerobic capacity) were significantly associated with physical work capacity and this relationship was even stronger at post-intervention assessment. Further, there were significant improvements across these physiologic measures in response to the delivered intervention. However, the change in these physiologic measures failed to predict the change in physical work capacity induced via HIFT. These findings point to the potential utility of HIFT as a unique challenge to individuals’ physiology beyond traditional resistance or aerobic training. Elucidating the translational impact of increasing work capacity via HIFT may be of great interest to health and fitness practitioners ranging from strength/conditioning coaches to physical therapists. AU - Crawford, Derek AU - Drake, Nicholas AU - Carper, Michael AU - DeBlauw, Justin AU - Heinrich, Katie DA - 2018/3// DO - 10.3390/sports6020026 IS - 2 KW - High-Intensity Functional Training KW - performance KW - work capacity PB - MDPI AG PY - 2018 SP - 26 EP - 26 TI - Are Changes in Physical Work Capacity Induced by High-Intensity Functional Training Related to Changes in Associated Physiologic Measures? T2 - Sports UR - /pmc/articles/PMC6026831/ UR - /pmc/articles/PMC6026831/?report=abstract UR - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6026831/ VL - 6 ER - TY - JOUR AB - Regular physical exercise is an established recommendation for preventing and treating the main modifiable cardiovascular risk factors, such as diabetes mellitus, hypertension, and dyslipidemia. Performing physical activity of moderate intensity for a minimum of 30 minutes 5 days a week or of high intensity for a minimum of 20 minutes 3 days a week improves functional capacity and is associated with reductions in the incidence of cardiovascular disease and mortality. Physical exercise induces physiological cardiovascular adaptations that improve physical performance, and only in extreme cases can these adaptations lead to an increased risk of physical exercise-associated complications. The incidence of sudden death or serious complications during physical exercise is very low and is concentrated in people with heart diseases or with pathological cardiac adaptation to exercise. Most of these cases can be detected by cardiology units or well-trained professionals. © 2014 Sociedad Espanõla de Cardiología. Published by Elsevier España, S.L.U. All rights. AU - Cordero, Alberto AU - Masiá, M. Dolores AU - Galve, Enrique DA - 2014/9// DO - 10.1016/j.recesp.2014.04.007 IS - 9 KW - Exercise KW - Health KW - Physical activity PB - Ediciones Doyma, S.L. PY - 2014 SP - 748 EP - 753 TI - Ejercicio físico y salud T2 - Revista Espanola de Cardiologia UR - http://www.revespcardiol.org/es-ejercicio-fisico-salud-articulo-S0300893214002656 UR - http://www.revespcardiol.org/es-ejercicio-fisico-salud-articulo-resumen-S0300893214002656?redirect=true VL - 67 ER - TY - JOUR AU - Shaw, I AU - Shaw, B S AU - Brown, G A AU - Cilliers, J F IS - 4 PY - 2010 SP - 166 EP - 169 TI - Concurrent resistance and aerobic training as protection against heart disease - PubMed T2 - Cardiovasc J Afr UR - https://pubmed.ncbi.nlm.nih.gov/20838717/ VL - 21 ER - TY - BOOK AU - Riebe, Deborah ; AU - Ehrman, Jonathan K ; AU - Liguori, Gary; AU - Magal, Meir; ED - Kluwer, Wolters ET - 10 PY - 2018 TI - ACSM's guidelines for exercise testing and prescription UR - https://www.worldcat.org/title/acsms-guidelines-for-exercise-testing-and-prescription/oclc/958942491 ER - TY - JOUR AU - Yancy, Clyde W. AU - Jessup, Mariell AU - Bozkurt, Biykem AU - Butler, Javed AU - Casey, Donald E. AU - Drazner, Mark H. AU - Fonarow, Gregg C. AU - Geraci, Stephen A. AU - Horwich, Tamara AU - Januzzi, James L. AU - Johnson, Maryl R. AU - Kasper, Edward K. AU - Levy, Wayne C. AU - Masoudi, Frederick A. AU - McBride, Patrick E. AU - McMurray, John J.V. AU - Mitchell, Judith E. AU - Peterson, Pamela N. AU - Riegel, Barbara AU - Sam, Flora AU - Stevenson, Lynne W. AU - Tang, W. H.Wilson AU - Tsai, Emily J. AU - Wilkoff, Bruce L. DO - 10.1161/CIR.0b013e31829e8776 IS - 16 PY - 2013 SP - 240 EP - 327 TI - 2013 ACCF/AHA guideline for the management of heart failure: A report of the american college of cardiology foundation/american heart association task force on practice guidelines T2 - Circulation VL - 128 ER - TY - JOUR AB - Resumen El Grupo Europeo de Trabajo sobre la Sarcopenia en Personas de Edad Avanzada (EWGSOP) elaboró una definición clínica práctica y unos criterios diagnósticos de consenso de la sarcopenia relacionada con la edad. El EWGSOP estuvo formado por representantes de cuatro organizaciones participantes, a saber, la Sociedad Europea de Medicina Geriátrica, la Sociedad Europea de Nutrición Clínica y Metabolismo, la Asociación Internacional de Gerontología y Geriatría-región europea y la Asociación Internacional de Nutrición y envejecimiento. Estas organizaciones refrendaron los hallazgos en el documento final. El grupo se reunió y abordó las preguntas siguientes, utilizando la bibliografía médica para ofrecer respuestas basadas en pruebas científicas: (i) ¿Qué es la sarcopenia? (ii) ¿Qué parámetros definen la sarcopenia? (iii) ¿Qué variables reflejan estos parámetros y qué instrumentos de medida y límites pueden utilizarse? (iv) ¿Cómo se relaciona la sarcopenia con la caquexia, la fragilidad y la obesidad sarcopénica? Para el diagnóstico de la sarcopenia, el EWGSOP recomienda utilizar la presencia de masa muscular baja + función muscular deficiente (fuerza o rendimiento). El EWGSOP aplica estas características de varias formas para definir estadios conceptuales, como ‘presarcopenia’, ‘sarcopenia’ y ‘sarcopenia grave’. El EWGSOP revisó una amplia variedad de herramientas que pueden utilizarse para medir las variables específicas de masa muscular, fuerza muscular y rendimiento físico. En este artí- culo se resumen los datos disponibles actualmente que definen los límites de sarcopenia según la edad y el sexo, se propone un algoritmo para detectar casos de sarcopenia en las personas de edad avanzada basándose en mediciones de la velocidad de la marcha, la fuerza de prensión y la masa muscular y se presenta una lista de criterios de valoración principales y secundarios propuestos con fines de investigación. Una vez se adopte una definición práctica de sarcopenia y se incluya en la corriente dominante de una evaluación geriá- trica exhaustiva, los pasos siguientes consistirán en definir la evolución natural de la sarcopenia y en desarrollar y definir un tratamiento eficaz. Palabras AU - Cruz Jentoft, Alfonso. AU - Baeyens, Jean Pierre AU - Bauer, Jurgen M. IS - 4 PY - 2018 SP - 412 EP - 423 TI - Sarcopenia: consenso europeo sobre su definición y diagnóstico. Informe del Grupo europeo de trabajo sobre la sarcopenia en personas de edad avanzada T2 - British Geriatrics Society VL - 39 ER - TY - GEN AU - ASDE G PY - 2020 TI - Manual de Usuario: dinamómetro electrónico CAMRY Mod: EH101. UR - www.generalasde.com ER - TY - GEN AU - OMRON PY - 2014 TI - Manual de Instrucciones. Balanza de control corporal Hbf-514c UR - http://pranascopio.uy/documentos/Manual_Omron_HBF-514.pdf ER - TY - JOUR AU - Borg, GA IS - 5 PY - 1982 SP - 377 EP - 381 TI - Psychophysical bases of perceived exertion - PubMed T2 - Med Sci Sports Exerc UR - https://pubmed.ncbi.nlm.nih.gov/7154893/ VL - 14 ER - TY - JOUR AB - Background: In many developed countries, the workforce is rapidly aging. Occupational demands however, have not decreased despite the fact that workers see a decline in physical work capacity with age. The purpose of this review is to examine the physiological adaptations to aging, the impact of aging on performance and the benefits of physical fitness in improving functional work capacity in aging individuals. Methods: An extensive search of the scientific literature was performed, acquiring published articles which examined the physiological changes associated with age-related decrements in the physical work capacity of healthy aging adults. The databases accessed included AARP Ageline, AccessScience, Annual Reviews, CISTI, Cochrane Library, Clinical Evidence, Digital Dissertations (Proquest), Embase, HealthSTAR, Medline, PubMed, Scopus, and PASCAL and included relevant information sites obtained on the world wide web. Results: While a great deal of variation exists, an average decline of 20% in physical work capacity has been reported between the ages of 40 and 60 years, due to decreases in aerobic and musculoskeletal capacity. These declines can contribute to decreased work capacity, and consequential increases in work-related injuries and illness. However, differences in habitual physical activity will greatly influence the variability seen in individual physical work capacity and its components. Well-organized, management-supported, work-site health interventions encouraging physical activity during work hours could potentially decrease the incidence of age-related injury and illness. Conclusions: Age-associated functional declines and the accompanying risk of work-related injury can be prevented or at least delayed by the practice of regular physical activity. Older workers could optimally pursue their careers until retirement if they continuously maintain their physical training. © 2008 Wiley-Liss, Inc. AU - Kenny, Glen P. AU - Yardley, Jane E. AU - Martineau, Lucie AU - Jay, Ollie DA - 2008/8// DO - 10.1002/ajim.20600 IS - 8 KW - Cardiorespiratory fitness KW - Endurance KW - Muscle strength KW - Physical fitness KW - Sex PB - John Wiley & Sons, Ltd PY - 2008 SP - 610 EP - 625 TI - Physical work capacity in older adults: Implications for the aging worker T2 - American Journal of Industrial Medicine UR - http://doi.wiley.com/10.1002/ajim.20600 VL - 51 ER - TY - JOUR AB - Monod and Scherrer (1965) showed that there was a linear relation between the maximal work and the maximal time over which the work was performed until the onset of local muscular exhaustion. This linear relation could be expressed by the equation: Wlim = a +b Wlim where maximal work (Wlim) was thought to result from the use of an energy reserve (a) and an energy reconstitution whose maximal rate was (b). We have extended this concept to total body work (bicycle ergometer). Eight male and eight female college students underwent exercise tests at 400, 350, 300, 275 and 300, 250, 200, 175 W respectively, to Ihe onset of fatigue. The regression analysis revealed that the linearity of individual plots was found to be 0-982 0.05). Multiple linear regression analysis showed that the variables of age and diagnosed diseases were the most effective factors of WAI (β=0.18 and P>0.05). Pearson test revealed a significant correlation between the number of diagnosed diseases and PWC index in age groups of 40-49 years. CONCLUSION Average WAI in this research, like other studies on similar jobs is in the acceptable level of >36. Work ability index and PWC index in different age groups did not show a significant correlation and this suggests that there are essential discrepancies in work ability evaluations made by each index and it is not possible to predict PWC index using WAI values. Given the PWC results and the level of nursing staff's activity (low, medium) the WAI is a suitable instrument to establish the professionals' abilities. This study revealed that 27.6% of individuals were subject to medium-low work ability risk (WAI<37), which was 1.8 times that of Finland's professional health Institute, which could be caused by shift working and increased working hours. AU - Habibi, Ehsanollah AU - Dehghan, Habibollah AU - Zeinodini, Mohhamad AU - Yousefi, Hosseinali AU - Hasanzadeh, Akbar DA - 2012/11// IS - 11 KW - Fax equation KW - hospital nurses KW - physical work capacity KW - work ability index PB - Wolters Kluwer -- Medknow Publications PY - 2012 SP - 776 EP - 82 TI - A Study on Work Ability Index and Physical Work Capacity on the Base of Fax Equation VO(2) Max in Male Nursing Hospital Staff in Isfahan, Iran. T2 - International journal of preventive medicine UR - http://www.ncbi.nlm.nih.gov/pubmed/23189229 UR - http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=PMC3506089 VL - 3 ER - TY - JOUR AB - This paper systematically reviews the scientific literature on the effects of individual and work-related factors on the Work Ability Index (WAI) Studies on work ability published from 1985 to 2006 were identified through a structured search in PubMed, and Web of Science. Studies were included if the WAI was used as measure of work ability and if quantitative information was presented on determinants of work ability. In total, 20 studies were included with 14 cross-sectional studies and six longitudinal studies. Factors associated with poor work ability, as defined by WAI, were lack of leisure-time vigorous physical activity, poor musculo- skeletal capacity, older age, obesity, high mental work demands, lack of autonomy, poor physical work environment, and high physical work load. The WAI is associated with individual characteristics, lifestyle, demands at work, and physical condition. This multifactorial nature of work ability should be taken into account in health promotion programmes aimed at maintaining and promoting the participation of the labour force and improvement of the performance at work. AU - Van Den Berg, T. I.J. AU - Elders, L. A.M. AU - De Zwart, B. C.H. AU - Burdorf, A. DA - 2009/4// DO - 10.1136/oem.2008.039883 IS - 4 PB - BMJ Publishing Group Ltd PY - 2009 SP - 211 EP - 220 TI - The effects of work-related and individual factors the work ability index: A systematic review T2 - Occupational and Environmental Medicine UR - https://oem.bmj.com/content/early/2008/11/18/oem.2008.039883 UR - https://oem.bmj.com/content/early/2008/11/18/oem.2008.039883.abstract VL - 66 ER - TY - JOUR AB - This study provides rate ratios for sickness absence in relation to workload, which was accessed by means of a job exposure matrix. Emphasis is given to diseases that are seldom studied by sickness absence data either because the incidence is low or because medical treatment is not supplemented by rest from work. A total of 42,508 employees from the metal processing and retail trade were followed for 3 years. Sick leave related to hypertension, ischemic heart diseases, ulcer, neurotic disorders, or work accidents was most frequent in employees exposed to physical demands and low control. In contrast, an inverse relation was observed for psychological demands, for which rate ratios decreased with increasing exposure. This finding might be an expression of work commitment or pressure to attend rather than of coping behavior, because both hard and soft diagnoses were considered. AU - Boedeker, Wolfgang DO - 10.1097/00043764-200112000-00010 IS - 12 KW - Absenteeism KW - Accidents KW - Commerce KW - Data Collection KW - Humans KW - MEDLINE KW - Metallurgy KW - NCBI KW - NIH KW - NLM KW - National Center for Biotechnology Information KW - National Institutes of Health KW - National Library of Medicine KW - Non-U.S. Gov't KW - Occupational / statistics & numerical data* KW - Occupational Diseases / epidemiology* KW - Population Surveillance KW - PubMed Abstract KW - Research Support KW - Sick Leave / statistics & numerical data* KW - United States / epidemiology KW - W Boedeker KW - Workload / psychology* KW - doi:10.1097/00043764-200112000-00010 KW - pmid:11765679 PB - Lippincott Williams and Wilkins PY - 2001 SP - 1081 EP - 1088 TI - Associations between workload and diseases rarely occurring in sickness absence data T2 - Journal of Occupational and Environmental Medicine UR - https://pubmed.ncbi.nlm.nih.gov/11765679/ VL - 43 ER - TY - JOUR AB - RESUMEN Antecedentes: La escala de Borg modifi cada es una escala visual análoga estandarizada en español que permite evaluar la percepción subjetiva de la difi cultad respiratoria o del esfuerzo físico ejercido; no existen estudios que analicen la correlación entre dicha escala y la saturación de oxígeno. Material y métodos: Estudio transversal, analítico y observacional realizado en la Unidad de Medicina Física y Rehabilitación Norte, en hombres y mujeres mayores de 18 años postinfartados que culminaron el programa de rehabilitación cardiaca. Se formaron dos grupos: fumadores (14 pacientes) y no fumadores (8 pacientes). Se tomó la saturación de oxígeno al reposo y durante la prueba de esfuerzo máxima, cada que su esfuerzo físico subía respecto a la escala de Borg modifi cada. Resultados: Se encontró un coefi ciente de correlación entre la escala de Borg modifi cada y la saturación de oxígeno de r =-0.995 y r =-0.911 en fumadores y no fumadores respectivamente, con una p < 0.001. Conclusiones: La alta correlación entre la escala de Borg modifi cada y la saturación de oxígeno en pacientes con diagnóstico de cardiopatía isquémi-ca hacen indispensable en los Servicios de Rehabilitación Cardiaca, la medición de la saturación de oxígeno como método de prescripción del ejercicio durante las pruebas de esfuerzo. Palabras clave: Escala de Borg modifi cada, saturación de oxígeno, cardiopatía isquémica. ABSTRACT Background: The modifi ed Borg scale is a standardized visual analog scale in Spanish that assesses subjective perception of breathing diffi culty or physical effort exerted. There are no studies analyzing the correlation between this scale and oxygen saturation. Material and methods: Cross-sectional, analytical and observational study done on men and women over 18 years culminating post infarcted cardiac rehabilitation program. Two groups, smokers (14 patients) and nonsmokers (8 patients). It took the oxygen saturation at rest and during maximal stress test, each up his physical exertion on the modifi ed Borg scale. Results: We found a correlation coeffi cient between the modifi ed Borg scale and oxygen saturation of r =-0.995 y r =-0.911 smokers and nonsmokers, respectively, with p < 0.001. Conclusions: The high correlation between the modifi ed Borg scale and oxygen saturation in patients with ischemic heart disease, make it indispensable in cardiac rehabilitation services to measure oxygen saturation as a method of exercise prescription for stress test. AU - Chávez, Andrés Valencia AU - Orozco, Jorge Hilario Jiménez AU - Marchán, Leticia Díaz AU - González, María Elena Mazadiego IS - 1 KW - Escala de Borg modificada KW - cardiopatía isquémica KW - saturación de oxígeno PB - Medigraphic PY - 2012 SP - 5 EP - 9 TI - Correlación entre la escala de Borg modificada y la saturación de oxígeno durante la prueba de esfuerzo máxima en pacientes postinfartados T2 - Revista Mexicana de Medicina Física y Rehabilitación UR - www.medigraphic.org.mx VL - 24 ER - TY - JOUR AU - Afshari, Davood AU - Siahi Ahangar, Atefeh AU - Mohi Pour, Sanaz AU - Ahmadi angali, Kambiz AU - Amirmoezi, Simin DO - 10.21859/johe.4.4.12 IS - 4 KW - aerobic capacity KW - anthropometric dimensions KW - astrand PY - 2018 SP - 12 EP - 19 TI - The effects of anthropometric and demographic factors on physical work capacity T2 - Journal of Occupational Hygiene Engineering VL - 4 ER - TY - JOUR AB - Las muertes maternas constituyen un grave problema de salud pública que puede evitarse. Se calcula que ocurren alrededor de 600 mil anualmente en el mundo, en su gran mayoría en los países "en desarrollo", donde el riesgo de las mujeres a morir por causas maternas es de una en 48, frente a una en 1,800 en los desarrollados. Las inmensas variaciones en las tasas de mortalidad materna (TMM) entre los países, e incluso a su interior, muestran su intrínseca vinculación con la pobreza. Pobreza que priva a grandes sectores de población del acceso a los mínimos satisfactores que todo ser humano necesita para sobrevivir y desarrollar sus capacidades. Estudios realizados muestran, sin embargo, cómo en las muertes maternas los efectos de la pobreza se ven potencializados por factores socioculturales que, generalmente, no son previstos ni tomados en cuenta al diseñar e instrumentar los programas de salud. De ahí la reiterada insistencia de la Organización Mundial de la Salud en que el abatimiento de esas muertes exige "ir más allá" de sus "causas inmediatas", a fin de identificar y modificar los factores que las generan, entre los cuales destacan los socioculturales. Dentro de un contexto global, el presente artículo se enfoca, particularmente, a la relación de las muertes maternas con dichos factores, al mismo tiempo que subraya la inaplazable necesidad de poner en marcha estrategias intersectoriales que las eviten y las condiciones para lograrlo. AU - Elu, Maria del Carmen AU - Santos Pruneda, Elsa CY - Mexico PY - 2004 SP - 44 EP - 52 TI - Mortalidad materna: una tragedia evitable T2 - Perinatol Reprod Hum UR - http://www.scielo.org.mx/scielo.php?script=sci_arttext&pid=S0187-53372004000100006 ER - TY - JOUR AB - RESUMEN Introducción: la mortalidad perinatal es consecuencia de la situación de salud de la materna, la interacción de factores biopsicosociales en la gestación y los atributos de calidad en la atención del binomio materno-fetal en los servicios de salud. Objetivo: analizar la mortalidad perinatal presentada en las cohortes 2012 y 2013 en la Clínica Universitaria Colombia. Metodología: estudio descriptivo retrospectivo con datos recolectados por el sub-sistema de vigilancia de mortalidad perinatal de la Clínica Universitaria Colombia. Complemento de la información a partir de revisión de historias Clínicas y Certificado de defunción. análisis de datos haciendo uso de la Matriz babies y el Modelo de demoras. Resultados: en 2012 se presentaron 72 eventos de mortalidad perinatal los cuales se asociaron en un 77.7% con riesgos de la salud materna, siendo la pre-eclampsia la principal morbilidad asociada. la tasa para este año fue de 23,6 por cada 1.000 nacidos vivos. en 2013 se presentaron 68 eventos los cuales se asociaron en un 64.1% con riesgos de la salud materna. desde el Modelo de demoras, para ambos años cumplen un papel relevante las demoras i, ii y iii. Conclusiones: la mortalidad perinatal de la Clínica Universitaria Colombia tiene un comportamiento semejante al descrito en la literatura. es necesario desarrollar acciones que propendan al reconocimiento de los riesgos biopsicosociales de las gestantes, a la garantía de derechos humanos sexuales y reproducti-vos, al conocimiento de signos y síntomas de alarma, y la generación de capacidades en el talento humano. Palabras clave: mortalidad perinatal; mortalidad infantil. Artículo original 146 Volumen 18 • No. 3 • Julio/Septiembre de 2015 Rev.Medica.Sanitas 18 (3): 145-152, 2015 INTRODUCCIÓN La mortalidad perinatal-MP en adelante-, se define como las muertes que ocurren en el periodo comprendido entre las 22 semanas completas de gestación o 154 días y los seis días posteriores al nacimiento en un producto de 500 o más gramos de peso (1). Estas pueden ser fetales o no fetales, y cuando ocurren entre el día 7 y 28 se conocen como mortalidades neonatales tardías (1). La MP es un reflejo de múltiples situaciones tales como la salud de la materna, la interacción de factores biopsicosociales en la gestación y los atributos de calidad en la atención del binomio materno-fetal en los servicios de salud. Una proporción importante de esta se encuentra asociada a la prematuridad, entre 50 a 72% según los estudios, la cual a su vez es principalmente un resultado de los trastornos hipertensivos del embarazo a nivel global , siendo un evento que ocurre preponderantemente en los países en vías de desarrollo (2). La prematuridad, de la misma manera, se encuentra en cerca del 29% de los casos de mortalidad neonatal tardía, siendo seguida por la asfixia neonatal y las enfermedades infecciosas, casos que son prevenibles en dos terceras partes (2) En países como España, se encuentra que la MP en su mayoría AU - Villalba Toquica, Carolina del Pilar AU - Martínez Silva, Pablo Andrés IS - 3 PY - 2015 SP - 145 EP - 152 TI - Mortalidad perinatal y neonatal temprana en la Clínica Universitaria Colombia. Análisis de las cohortes 2012 y 2013 T2 - Revista Médica Sanitas VL - 18 ER - TY - JOUR AU - Granda Carvajal, Paula Andrea CY - Medellin PY - 216 TI - CALIDAD DE LA ATENCIÓN EN SALUD, UNA MIRADA DESDE LA TEORÍA DE SISTEMAS. REVISIÓN DE LA LITERATURA. UR - https://repository.ces.edu.co/bitstream/10946/714/1/Tesis_Calidad_Teoria_sistemas_PAGC.pdf ER - TY - JOUR AU - Forrellat Barrios, Mariela IS - 2 PY - 2014 TI - Calidad en los servicios de salud: un reto ineludible T2 - Rev Cubana Hematol Inmunol Hemoter UR - http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S0864-02892014000200011 VL - 30 ER - TY - GEN TI - Gerencia Estrategica - La Gerencia en las Organizaciones UR - https://sites.google.com/site/lagerenciaenlasorganizaciones/gerencia-estrategica ER - TY - GEN AU - Ministerio de salud y proteccion social PY - 2020 TI - Auditoría para el mejoramiento de la calidad UR - https://www.minsalud.gov.co/salud/Paginas/auditoria-parael-mejoramiento-dela-calidad.aspx ER - TY - JOUR AB - La gerencia estratégica en las organizaciones reviste gran importancia, al ser quien define el direccionamiento del negocio en un futuro inmediato; en este sentido, las acciones que delinean tal direccionamiento, deben estar alineadas con el pensamiento de quienes se encuentran al frente de los negocios. El objetivo de este trabajo, consiste en analizar la gerencia estratégica en las organizaciones como herramienta para la toma de decisiones y responder a las exigencias del entorno competitivo. Se asume para efectos de la investigación desarrollada, una postura enmarcada en la metodología cualitativa, con enfoque documental, sentando las bases para una investigación de mayor alcance. Se revisan documentos especializados con el fin de realizar una disertación teórica inicial, tales como Thompson y Strickland (2004), David (2003); Chiavenato (2011), entre otros. Los resultados indican que la literatura especializada en el área es diversa y arrojan elementos esenciales para la construcción del pensamiento estratégico, este último caracterizado por el desarrollo de procesos críticos en la mente del estratega que coadyuvan a mejorar las capacidades de las organizaciones, en aras de formular y desplegar estrategias con mayor efectividad. El pensamiento estratégico no se concentra únicamente en la elaboración de planes, va más allá, permitiendo cambiar modelos mentales de quienes toman las decisiones en las organizaciones. AU - González, Jorge AU - Salazar, Flor AU - Ortiz, Raúl AU - Verdugo, Darwin DO - 10.36390/telos211.12 IS - 1 PY - 2019 SP - 242 EP - 267 TI - Gerencia estratégica: herramienta para la toma de decisiones en las organizaciones T2 - Telos VL - 21 ER - TY - BOOK AB - The Agricultural Ingeneer Dr. Teruo Higa, professor of Horticulture at the University of The Ryukyus in Okinawa, Japan creates a technique in the 80th de- cade related with the use of efficient microorganism. This technology is the basis of the present review aim at providing information about groups of benevolent microorganisms such as: lactic acid bacteria, photo- trophic bacteria, actinomycetes group, yeast group and fungi present in natural ecosystems which are physiologically compatible with each other. Efficient Microorganisms, as a microbial inoculantion, resto- re soil microbiological balance, improve its physical and chemical conditions, increase crop production and protection, preserve natural resources, and ge- nerate a more sustainable agriculture and environ- ment. They can be used in the livestock (cattle, por- ciculture and poultry) for animal husbandry and the increase of productive variables. All this maximizes the efficiency of the systems and the management of excreta and facilities. AU - Mihi Ramirez, Antonio AU - River Rodriguez, Hugo Alberto PY - 2008 TI - El mejoramiento Continuo ER - TY - JOUR AB - Cada día cobra mayor importancia que los dirigentes conozcan los fundamentos teóricos que explican las razones que impulsan a los trabajadores a conseguir una meta u objetivo. El objetivo es reconocer las bases conceptuales de cada una de las categorías que serán tratadas en este artículo: desarrollo organizacional, cultura organizacional y clima organizacional. Se realizó una revisión bibliográfica y documental sobre el tema en fuentes de datos digitales indexadas Scielo, EBSCO y material disponible en el repositorio de la biblioteca de la Escuela Nacional de Salud Pública de Cuba. Se usaron los descriptores: desarrollo organizacional, cultura organizacional y clima organizacional. El tratamiento de los datos se realizó mediante el análisis de contenido de tipo directo. El desarrollo trata las definiciones, los elementos significativos de cada categoría estudiada y se enfatiza en que la organización es un sistema formal creado para un objeto, es diseñada artificialmente para que cumpla la meta, donde lo primero y fundamental debe ser el grupo de personas que la conforman. La organización como ente artificial construido para lograr un fin, vive en constante perfeccionamiento en respuesta a las demandas de la sociedad y se destaca que estos cambios operan sobre la cultura, el clima y el desarrollo organizacional. Se considera la necesidad de hablar de cultura, clima y desarrollo organizacional implica un llamado en la preparación de los directos en salud pública, de manera tal que les permita tener las competencias necesarias para desarrollar estudios organizacionales, en búsqueda por elevar la productividad y la calidad institucional. AU - Segredo Pérez, Alina María AU - García Milian, Ana Julia AU - León Cabrera, Pablo AU - Perdomo Victoria, Irene IS - 24 KW - clima organizacional KW - cultura organizacional KW - desarrollo organizacional PY - 2016 SP - 86 EP - 99 TI - Desarrollo organizacional, cultura organizacional y clima organizacional. Una aproximación conceptual T2 - Revista de Información científica para la Dirección en Salud. INFODIR VL - 0 ER - TY - GEN AU - Espinel Torres, Adriana IS - 5 KW - ΕΡΨΣ-ΑΓΑΠΗ PY - 2019 SP - 55 EP - 55 TI - Propuesta de un modelo de auditoria de calidad en salud, basada en la norma iso 19011:2012 para el subsistema de salud de las fuerzas militares T2 - Universidad de America VL - 8 ER - TY - GEN TI - Secretaría de Planeación UR - http://www.cundinamarca.gov.co/Home/SecretariasEntidades.gc/Secretariadeplaneacion/SecretariadeplaneacionDespliegue/aspoliyplanprog_contenidos/csecreplanea__plandesarrdep_2020_2023 ER - TY - JOUR AB - The aim of this rapid analysis was to investigate the spatial patterns of COVID-19 emergence across counties in Colorado. In the U.S. West, Colorado has the second highest number of cases and deaths, second only to California. Colorado is also reporting, like other states, that communities of color and low-income persons are disproportionately affected by COVID-19. Using GIS and correlation analysis, this study explored COVID-19 incidence and deaths from March 14 to April 8, 2020, with social determinants and chronic conditions. Preliminary results demonstrate that COVID-19 incidence intensified in mountain communities west of Denver and along the Urban Front Range, and evolved into new centers of risk in eastern Colorado. Overall, the greatest increase in COVID-19 incidence was in northern Colorado, i.e., Weld County, which reported the highest rates in the Urban Front Range. Social and health determinants associated with higher COVID-19-related deaths were population density and asthma, indicative of urban areas, and poverty and unemployment, suggestive of rural areas. Furthermore, a spatial overlap of high rates of chronic diseases with high rates of COVID-19 may suggest a broader syndemic health burden, where comorbidities intersect with inequality of social determinants of health. AU - Ramírez, Ivan J. AU - Lee, Jieun DO - 10.3390/ijerph17113856 IS - 11 KW - COVID-19 KW - Colorado KW - Coronavirus KW - GIS KW - Multiple chronic conditions KW - Pandemic KW - Social determinants of health KW - Spatial analysis PY - 2020 SP - 1 EP - 15 TI - COVID-19 emergence and social and health determinants in Colorado: A rapid spatial analysis T2 - International Journal of Environmental Research and Public Health VL - 17 ER - TY - JOUR AB - The COVID-19 pandemic has manifested more than a health crisis and has severely impacted on social, economic, and development crises in the world. The relationship of COVID-19 with countries’ economic and other demographic statuses is an important criterion with which to assess the impact of this current outbreak. Based on available data from the online platform, we tested the hypotheses of a country’s economic status, population density, the median age of the population, and urbanization pattern influence on the test, attack, case fatality, and recovery rates of COVID-19. We performed correlation and multivariate multinomial regression analysis with relative risk ratio (RRR) to test the hypotheses. The correlation analysis showed that population density and test rate had a significantly negative association (r = −0.2384, p = 0.00). In contrast, the median age had a significant positive correlation with recovery rate (r = 0.4654, p = 0.00) and case fatality rate (r = 0.2847, p = 0.00). The urban population rate had a positive significant correlation with recovery rate (r = 0.1610, p = 0.04). Lower-middle-income countries had a negative significant correlation with case fatality rate (r= −0.3310, p = 0.04). The multivariate multinomial logistic regression analysis revealed that low-income countries are more likely to have an increased risk of case fatality rate (RRR = 0.986, 95% Confidence Interval; CI = 0.97−1.00, p < 0.05) and recovery rate (RRR = 0.967, 95% CI = 0.95–0.98, p = 0.00). The lower-income countries are more likely to have a higher risk in case of attack rate (RRR = 0.981, 95% CI = 0.97–0.99, p = 0.00) and recovery rate (RRR = 0.971, 95% CI = 0.96–0.98, p = 0.00). Similarly, upper middle-income countries are more likely to have higher risk in case of attack rate (RRR = 0.988, 95% CI = 0.98–1.0, p = 0.01) and recovery rate (RRR = 0.978, 95% CI = 0.97–0.99, p = 0.00). The low- and lower-middle-income countries should invest more in health care services and implement adequate COVID-19 preventive measures to reduce the risk burden. We recommend a participatory, whole-of-government and whole-of-society approach for responding to the socio-economic challenges of COVID-19 and ensuring more resilient and robust health systems to safeguard against preventable deaths and poverty by improving public health outcomes. AU - Hassan, Mohammad Mahmudul AU - Kalam, Md. Abul AU - Shano, Shahanaj AU - Nayem, Md. Raihan Khan AU - Rahman, Md. Kaisar AU - Khan, Shahneaz Ali AU - Islam, Ariful DO - 10.3390/jrfm13090194 IS - 9 PY - 2020 SP - 194 EP - 194 TI - Assessment of Epidemiological Determinants of COVID-19 Pandemic Related to Social and Economic Factors Globally T2 - Journal of Risk and Financial Management VL - 13 ER - TY - JOUR AB - The endogenous adaptation of economic agents, that may adjust their trade network in response to infection rates, can have the perverse effect of increasing the overall systemic infectiveness of a disease. We study a dynamical model over two geographically distinct but interacting markets, to better understand theoretically the mechanism at play. We also discuss analogies with the 2018 African Swine Fever, and provide empirical motivation from the Italian National Bovine Database, for the period 2006–2013. AU - Muscillo, Alessio AU - Pin, Paolo AU - Razzolini, Tiziano DO - 10.1016/j.jebo.2021.01.004 KW - Endogenous spreading KW - Exogenous shocks KW - Infectious disease KW - Islands model KW - Italian National Bovine Database PB - Elsevier B.V. PY - 2021 SP - 508 EP - 532 TI - Spreading of an infectious disease between different locations T2 - Journal of Economic Behavior and Organization UR - https://doi.org/10.1016/j.jebo.2021.01.004 VL - 183 ER - TY - JOUR AB - Attention mechanisms play a central role in NLP systems, especially within recurrent neural network (RNN) models. Recently, there has been increasing interest in whether or not the intermediate representations offered by these modules may be used to explain the reasoning for a model's prediction, and consequently reach insights regarding the model's decision-making process. A recent paper claims that 'Attention is not Explanation' (Jain and Wallace, 2019). We challenge many of the assumptions underlying this work, arguing that such a claim depends on one's definition of explanation, and that testing it needs to take into account all elements of the model. We propose four alternative tests to determine when/whether attention can be used as explanation: a simple uniform-weights baseline; a variance calibration based on multiple random seed runs; a diagnostic framework using frozen weights from pretrained models; and an end-to-end adversarial attention training protocol. Each allows for meaningful interpretation of attention mechanisms in RNN models. We show that even when reliable adversarial distributions can be found, they don't perform well on the simple diagnostic, indicating that prior work does not disprove the usefulness of attention mechanisms for explainability. AU - Benatar, Salomon IS - 7/8 PY - 2020 SP - 148 EP - 162 TI - The most powerful healt-promoting forces in COVID-19 are social T2 - S Afr J Sci VL - 116 ER - TY - JOUR AU - Valero-ubierna, Carmen AU - R-delamo, Juan Luis AU - Id, Mario Rivera-izquierdo AU - Martı, Silvia AU - Bele, Ana AU - Cabrero-rodrı, Celia AU - Guirado-ruiz, Pedro Antonio AU - Jesu, Antonio IS - 6 PY - 2020 SN - 1111111111 SP - 1 EP - 13 TI - factors on admission associated with COVID- 19 mortality in hospitalized patients : A retrospective observational study T2 - PLoS ONE VL - 15 ER - TY - JOUR AB - Background: Studies related to the SARS-CoV-2 spikes in the past few months, while there are limited studies on the entire outbreak-suppressed cycle of COVID-19. We estimate the cause-specific excess mortality during the complete circle of COVID-19 outbreak in Guangzhou, China, stratified by sociodemographic status. Methods: Guangzhou Center for Disease Control Prevention provided the individual data of deaths in Guangzhou from 1 January 2018 through 30 June 2020. We applied Poisson regression models to daily cause-specific mortality between 1 January 2018 and 20 January 2020, accounting for effects of population size, calendar time, holiday, ambient temperature and PM2.5. Expected mortality was estimated for the period from 21 January through 30 June 2020 assuming that the effects of factors aforementioned remained the same as described in the models. Excess mortality was defined as the difference between the observed mortality and the expected mortality. Subgroup analyses were performed by place of death, age group, sex, marital status and occupation class. Results: From 21 January (the date on which the first COVID-19 case occurred in Guangzhou) through 30 June 2020, there were three stages of COVID-19: first wave, second wave, and recovery stage, starting on 21 January, 11 March, and 17 May 2020, respectively. Mortality deficits were seen from late February through early April and in most of the time in the recovery stage. Excesses in hypertension deaths occurred immediately after the starting weeks of the two waves. Overall, we estimated a deficit of 1051 (95% eCI: 580, 1558) in all-cause deaths. Particularly, comparing with the expected mortality in the absence of COVID-19 outbreak, the observed deaths from pneumonia and influenza substantially decreased by 49.2%, while deaths due to hypertension and myocardial infarction increased by 14.5 and 8.6%, respectively. In-hospital all-cause deaths dropped by 10.2%. There were discrepancies by age, marital status and occupation class in the excess mortality during the COVID-19 outbreak. Conclusions: The excess deaths during the COVID-19 outbreak varied by cause of death and changed temporally. Overall, there was a deficit in deaths during the study period. Our findings can inform preparedness measures in different stages of the outbreak. AU - Li, Li AU - Hang, Dong AU - Dong, Han AU - Yuan-Yuan, Chen AU - Bo-Heng, Liang AU - Ze-Lin, Yan AU - Zhou, Yang AU - Chun-Quan, Ou AU - Peng-Zhe, Qin DO - 10.1186/s12889-021-10771-3 IS - 1 KW - China KW - Coronavirus disease 2019 KW - Excess mortality KW - Guangzhou KW - Sociodemographic status KW - Temporal dynamic PY - 2021 SP - 1 EP - 11 TI - Temporal dynamic in the impact of COVID− 19 outbreak on cause-specific mortality in Guangzhou, China T2 - BMC Public Health VL - 21 ER - TY - JOUR AB - Background: COVID 19 disease has a wide spectrum of severity. This has made the study of the risk factors affecting the severity, open for research, beginning from blood grouping to obesity and other comorbidities. The infectious nature of the disease made it important to take very strict measures in infection control through all the medical facilities. Maintaining the wellbeing of health care workers is a priority during this pandemic Aim: This study aims to find out the prevalence of COVID - 19 among PHCC staff during the period of March to end of September 2020 and to correlate between the place of work and position of the staff and to determine the risk factors associated with COVID-19 infection (age, gender, pre-existing Comorbidities, and workplace). Methods: A cross-sectional descriptive study design without any staff identifiers, data for all PHCC staff attending primary health care and their characteristics: Sociodemographic data: Age, Gender, Nationality, Weight, Height, BMI, Job title, PCR test results, Medical history, Place of Work (health care center), blood group captured through medical electronic system (CERNER). Results: A total 5,062 staff were included, 1,541 (30.4 %) were males, 3,521 (69.6%) were females. Overall positive COVID19 cases were 489 representing 9.7% of the sample and the total negative cases were 4,573 representing 90.3% of the sample. 348 (71.2%) positive cases were females and 141 (28.8%) positive cases were males. Of the total sample, medical staff were 4,061 and the non-medical sample were 1,001. Among medical staff the positive cases were 349 (8.6%) and 140 positive cases were non-medical staff, 14 % of 1001 total cases. Conclusion: Although PHCC also adopted a staff protection policy which included the waiver of attendance registration, the use of (masks, gloves, PPE), hand hygiene, isolation rooms for swabbing and the proper management of medical waste that resulted from dealing with COVID -19 patients, the prevalence of Covid 19 infection among PHCC staff during the period from march first till 30 September found to be 9.7 %, but neither the position at work or comorbidities were found to be statistically significant with COVID 19 infection. Pharmacists were the most exposed medical staff category to COVID19 infection due to direct contact with all patients visiting PHCC, while dentists were second because they dealt with open mouth patients. Of non-medical staff, cashiers and billing staff were the highest category because the deal with all visitors and are exposed to probably infected material ( redit cards, currency) in addition to lack of awareness and training. No statistical significant results were found among comorbidities cases, reflecting the fact that their exposure is not affected by exposure at work rather than their community exposure. AU - Kahlout, A M AU - ALhubidi, K AU - AlMesaifri, M A AU - AL Mansour, T AU - Khudadad, H DO - 10.5742/MEWFM.2021.94032 IS - 4 PY - 2021 SP - 84 EP - 104 TI - The prevalence of COVID 19 among PHCC workers and its relation to place of works and medical comorbidities T2 - World Family Medicine VL - 19 ER - TY - JOUR AB - The activities performed by Canadian workers in some occupations may increase the risk of exposure to infectious diseases such as COVID-19. This research note explores how occupational exposure risks vary by labor force characteristics using publicly available Canadian data in combination with a data set providing information on the level of physical proximity and frequency of exposure to infections or diseases faced by workers in different occupations. The results show important sociodemographic differences. First, women work in occupations associated with significantly higher average risks of exposure to COVID-19 than men. This is driven by their overrepresentation in high-risk broad occupational categories such as health occupations. Second, older workers (65 years or more), a group vulnerable to COVID-19, appear to work in occupations requiring performing activities characterized by a lower level of physical proximity than their younger colleagues, with minimal differences in the frequency of exposure to diseases or infections. Finally, workers in low-income occupations are employed in occupations that put them at greater risk of exposure to COVID-19 than other workers. This is especially the case for women, immigrants, and members of visible minority groups in low-income occupations. More broadly, this research note provides insights into the health-related dimension of the literature on occupational tasks and labor market stratification. AU - St-Denis, Xavier DO - 10.1111/cars.12288 IS - 3 PY - 2020 SP - 399 EP - 452 TI - Sociodemographic Determinants of Occupational Risks of Exposure to COVID-19 in Canada T2 - Canadian Review of Sociology VL - 57 ER - TY - JOUR AB - BACKGROUND Covid-2019, caused by severe acute respiratory syndrome-coronavirus-2 (SARS CoV2), is an ongoing pandemic that emerged from China in November 2019. It has affected millions of people worldwide causing significant morbidity and mortality. We wanted to analyse the clinical and demographic profile of Covid-19 patients admitted in a tertiary-care-centre in the central part of Rajasthan, compare their characteristics with other studies published from parts of NorthernIndia and identify factors associated with delayed recovery and mortality. METHODS This was a retrospective observational analysis of the clinical features, and epidemiological profile of Covid-19 positive patients admitted at a tertiary-carecentre in the Central part of Rajasthan. RESULTS A total of 422 patients was enrolled in the study. The male: female ratio was 1.34 with a mean age of 34.1 years. Almost 195 (46.2 %) patients were in the age group of 20 - 40 years. Respiratory diseases were the most common co-morbidity seen in 36 patients (8.53 %), diabetes-mellitus in 28 patients (6.63 %), hypertension in 22 patients (5.2 %). Fever was the commonest presenting symptom (N = 98, 77.17 %), followed by cough (N = 85, 66.93 %), and breathlessness (N = 51, 45.67 %). Factors significantly associated with mortality were age group of 60 - 80 year (P < 0.001), presence of co-morbidities (P < 0.001) and history of smoking & alcohol consumption (P < 0.001). Among co-morbidities diabetes-mellitus, hypertension, chronic-respiratory-diseases & chronic-kidneydiseases had significant impact on mortality. Absence of co-morbidity, lack of addiction and symptoms at the time of presentation were associated with an earlier conversion of reverse transcription polymerase chain reaction (RT-PCR) report. CONCLUSIONS Clinical spectrum of COVID 19 varies widely. Presence of comorbidities, addiction, radiological features has a drastic impact on mortality and duration of infectivity. KEYWORDS SARS CoV-2, Covid-19, RT PCR, Coronavirus AU - Arora, Piyush AU - Mittal, Himanshu AU - Gupta, Neeraj AU - Jimmy, Jose K. AU - Jain, Khushboo AU - Sharma, Arpit DO - 10.18410/jebmh/2021/152 IS - 13 KW - coronavirus KW - corresponding author KW - covid-19 KW - dr KW - himanshu mittal KW - rt pcr KW - sars cov-2 PY - 2021 SP - 773 EP - 777 TI - Sociodemographic Factors and Clinical Profile of Covid-19 Patients Admitted in a Tertiary Care Centre of Central Rajasthan, India T2 - Journal of Evidence Based Medicine and Healthcare VL - 8 ER - TY - JOUR AB - The COVID-19 pandemic has had disproportionately negative impacts on socially disadvantaged and underserved populations around the world. Inequality and the related social determinants that impact certain groups are directly related to the adverse health outcomes of vulnerable populations during the pandemic. People in disadvantaged communities are generally more prone to occupational exposure to the virus and tend to have limited access to health care and higher rates of comorbidities. Outcomes related to widespread school closures are also of particular concern for underserved communities. Additionally, these populations are more susceptible to the negative economic outcomes of the pandemic. There is an urgent need for research and policy solutions regarding the impact of the COVID-19, with particular attention to the needs of disadvantaged and vulnerable populations, a foundation for which is offered in this discussion. AU - McNeely, Connie L. AU - Schintler, Laurie A. AU - Stabile, Bonnie DO - 10.1002/wmh3.370 IS - 3 KW - COVID-19 KW - culture of health KW - disparities KW - social determinants PY - 2020 SP - 206 EP - 217 TI - Social Determinants and COVID-19 Disparities: Differential Pandemic Effects and Dynamics T2 - World Medical and Health Policy VL - 12 ER - TY - JOUR AB - Objectives: The aim of this study was to assess how different social determinants of health (SDoH) may be related to variability in coronavirus disease 2019 (COVID-19) rates in cities and towns in Massachusetts (MA). Methods: Data about the total number of cases, tests, and rates of COVID-19 as of June 10, 2020 were obtained for cities and towns in MA. The data on COVID-19 were matched with data on various SDoH variables at the city and town level from the American Community Survey. These variables included information about income, poverty, employment, renting, and insurance coverage. We compared COVID-19 rates according to these SDoH variables. Results: There were clear gradients in the rates of COVID-19 according to SDoH variables. Communities with more poverty, lower income, lower insurance coverage, more unemployment, and a higher percentage of the workforce employed in essential services, including healthcare, had higher rates of COVID-19. Most of these differences were not accounted for by different rates of testing in these cities and towns. Conclusions: SDoH variables may explain some of the variability in the risk of COVID-19 across cities and towns in MA. Data about SDoH should be part of the standard surveillance for COVID-19. Efforts should be made to address social factors that may be putting communities at an elevated risk. AU - Hawkins, Devan DO - 10.3961/jpmph.20.256 IS - 4 KW - Covid-19 KW - Inequality KW - Social determinants KW - United States PY - 2020 SP - 220 EP - 227 TI - Social determinants of covid-19 in massachusetts, United States: An ecological study T2 - Journal of Preventive Medicine and Public Health VL - 53 ER - TY - JOUR AB - Background: The outbreak of COVID-19 has laid unprecedented threats and challenges to health workers (HWs) in Wuhan, China. We aimed to assess the sociodemographic characteristics and hospital support measures associated with the immediate psychological impact on HWs at Tongji Hospital in Wuhan during COVID-19 outbreak. Methods: We conducted a single-center, cross-sectional survey of HWs via online questionnaires between February 8th and 10th, 2020. We evaluated stress, depression and anxiety by IES-R, PHQ-9, and GAD-7, respectively. We also designed a questionnaire to assess the perceptions of threat of COVID-19, and the satisfactions of the hospital's support measures. Multivariate logistic regressions were used to identify associated variables of acute stress, depression, and anxiety. Findings: We received 5062 completed questionnaires (response rate, 77.1%). 29.8%, 13.5% and 24.1% HWs reported stress, depression and anxiety symptoms. Women (odds ratio [OR], 1.31; 95% CI, 0.47–0.97; p = 0.032), years of working >10 years (OR, 2.02; 95% CI, 1.47–2.79; p<0.001), concomitant chronic diseases (OR, 1.51; 95% CI, 1.27–1.80; p<0.001), history of mental disorders (OR, 3.27; 95% CI, 1.77–6.05; p<0.001), family members or relatives confirmed or suspected (OR, 1.23; 95% CI, 1.02–1.48; p = 0.03), hospital-based and department-based care (OR, 0.76; 95% CI, 0.60–0.97; p = 0.024) and full coverage of all departments for avoiding nosocomial infection (OR, 0.69; 95% CI, 0.53–0.89; p = 0.004) were associated with stress. Interpretation: Women and those who have more than 10 years of working, concomitant chronic diseases, history of mental disorders, and family members or relatives confirmed or suspected are susceptible to stress, depression and anxiety among HWs during the pandemic. In addition, since HWs often have a greater stigma against mental problems than the general public, it is worthwhile to address the needs of the HWs during this pandemic and to provide appropriate psychological supports for those people at high risk of mental problems. AU - Zhu, Zhou AU - Xu, Shabei AU - Wang, Hui AU - Liu, Zheng AU - Wu, Jianhong AU - Li, Guo AU - Miao, Jinfeng AU - Zhang, Chenyan AU - Yang, Yuan AU - Sun, Wenzhe AU - Zhu, Suiqiang AU - Fan, Yebin AU - Chen, Yuxi AU - Hu, Junbo AU - Liu, Jihong AU - Wang, Wei DO - 10.1016/j.eclinm.2020.100443 PB - Elsevier Ltd PY - 2020 TI - COVID-19 in Wuhan: Sociodemographic characteristics and hospital support measures associated with the immediate psychological impact on healthcare workers T2 - EClinicalMedicine VL - 24 ER - TY - JOUR AU - Brouard, Sylvain AU - Vasilopoulos, Pavlos AU - Becher, Michael DO - 10.1017/S0008423920000335 IS - 2 PY - 2020 SP - 253 EP - 258 TI - Sociodemographic and psychological correlates of compliance with the Covid-19 public health measures in France T2 - Canadian Journal of Political Science VL - 53 ER - TY - JOUR AB - The COVID-19 pandemic led to a lockdown in European countries in the first half of 2020, including stay-at-home orders and closure of non-essential businesses. To mitigate the detrimental effects on the financial stress of employees and households, the UK government implemented a furlough scheme that temporarily secured earnings up to 80 percent of regular pay. Other employees were at risk of reduced work hours or permanent job loss. Using data from the UK Household Longitudinal Study COVID-19 Supplement, this study examines the extent to which different earnings groups and sociodemographic groups (gender, race/ethnicity, class background) became exposed to economic hardship between March and May of 2020. Results indicate that lower earnings groups were more than twice as likely to experience economic hardship relative to top quintile earners. Furthermore, among pre-COVID employed individuals, men and whites had a lower probability of being furloughed or dismissed from work. Analyses indicate that these are to a large extent attributable to gender earnings inequalities within occupations and the fact that women and racial-ethnic minorities are employed in essential occupations. AU - Witteveen, Dirk DO - 10.1016/j.rssm.2020.100551 IS - September KW - COVID-19 KW - Class background KW - Ethnicity KW - Gender KW - Income loss KW - Job loss KW - Labor market inequality KW - Occupational status KW - Race KW - Recession PB - Elsevier Ltd PY - 2020 SP - 100551 EP - 100551 TI - Sociodemographic inequality in exposure to COVID-19-induced economic hardship in the United Kingdom T2 - Research in Social Stratification and Mobility UR - https://doi.org/10.1016/j.rssm.2020.100551 VL - 69 ER - TY - JOUR AB - Many governments have implemented social distancing and lockdown measures to curb the spread of the novel coronavirus (COVID-19). Using province-level geolocation data from Italy, we document that political disbelief can limit government policy effectiveness. Residents in provinces leaning towards extreme right-wing parties show lower rates of compliance with social distancing order. We also find that, during the Italian lockdown, provinces with high protest votes virtually disregarded all social distancing orders. On the contrary, in provinces with higher political support for the current political legislation, we found a higher degree of social distancing compliance. These results are robust to controlling for other factors, including time, geography, local COVID-19 cases and deaths, healthcare hospital beds, and other sociodemographic and economic characteristics. Our research shows that bipartisan support and national responsibility are essential to implement and manage social distancing efficiently. From a broader perspective, our findings suggest that partisan politics and discontent with the political class (i.e., protest voting) might significantly affect human health and the economy. AU - Barbieri, Paolo Nicola AU - Bonini, Beatrice DO - 10.1007/s40888-021-00224-w IS - 2 KW - COVID-19 KW - Coronavirus KW - Geolocation data KW - Political belief KW - Protest vote PB - Springer International Publishing PY - 2021 SN - 0123456789 SP - 483 EP - 504 TI - Political orientation and adherence to social distancing during the COVID-19 pandemic in Italy T2 - Economia Politica UR - https://doi.org/10.1007/s40888-021-00224-w VL - 38 ER - TY - JOUR AB - The coronavirus disease (COVID-19) pandemic has increased unemployment and food insecurity in the United States (US). Prior to the pandemic, college students exhibited higher rates of food insecurity than nonstudent households. The objectives of this study were to assess the prevalence and determinants of food insecurity among college students during the COVID-19 pandemic. We administered an online survey to 651 students on three diverse campuses at a state-funded university in Texas, US, in May 2020. Food security was assessed using a multistep approach that included the 2-item Food Sufficiency Screener and 6-Item USDA Food Security Survey Module (FSSM). Overall, 34.5% of respondents were classified as food insecure within the last 30 days. The strongest predictors of food insecurity were change in current living arrangement (OR = 2.70, 95% CI: 2.47, 2.95), being furloughed (OR = 3.22, 95% CI: 2.86, 3.64), laid off (OR = 4.07, 95% CI: 3.55, 4.66), or losing part-time work (OR = 5.73, 95% CI: 5.09, 6.46) due to the COVID-19 pandemic. These findings highlight the high prevalence of food insecurity among college students during the COVID-19 pandemic, with students who experienced housing insecurity and/or loss of income due to the pandemic being impacted the most. AU - Owens, Meghan R AU - Brito-silva, Francilia AU - Kirkland, Tracie AU - Moore, Carolyn E AU - Davis, Kathleen E AU - Patterson, Mindy A AU - Miketinas, Derek C AU - Tucker, Wesley J IS - 9 KW - coronavirus KW - females KW - food security KW - housing insecurity KW - hunger KW - unemployment PY - 2020 SP - 1 EP - 18 TI - Prevalence and Social Determinants of Food Insecurity among College Students during the COVID-19 Pandemic T2 - Nutrients VL - 12 ER - TY - JOUR AB - With the COVID-19 pandemic threatening millions of lives around the world with no clear promises for treatment or vaccine yet, motivating the public to change their behaviors to prevent the spread of the disease becomes crucial and moral imperative. The current study investigated the associations between self-reported intentions to perform protective behaviors against COVID-19, the seven constructs of the Protection Motivation Theory PMT, trust in government, and sociodemographic factors within the general population in Kuwait. A cross-sectional design was adapted to explore the associations between study factors in a nonprobability voluntary response sample of 679 participants who completed an online public survey. Results indicate that the scores of trust in government and the severity, vulnerability, response efficacy, and self-efficacy subconstructs of the PMT were positively related to protective behavior intention, whereas intrinsic and extrinsic reward and response cost subconstructs were negatively associated with protective behavior intention. The results were discussed considering previous literature and future applications. AU - Al-Rasheed, Malak DO - 10.1080/19371918.2020.1806171 IS - 7 KW - COVID-19 KW - Kuwait KW - Protective behaviors KW - protection motivation theory KW - social work KW - trust in government PB - Routledge PY - 2020 SP - 546 EP - 556 TI - Protective Behavior against COVID-19 among the Public in Kuwait: An Examination of the Protection Motivation Theory, Trust in Government, and Sociodemographic Factors T2 - Social Work in Public Health UR - https://doi.org/10.1080/19371918.2020.1806171 VL - 35 ER - TY - JOUR AB - OBJECTIVE Coronavirus (COVID-19) pandemic disease forced different countries to adopt quarantine measures. These actions could have an impact on mental health in the general population. The objective of this study was to analyze the differences in psychopathological symptoms shown by Spanish general population during the COVID-19 quarantine based on sociodemographic, occupational and environmental-contextual variables. METHODS A cross-sectional pilot study was performed in a sample of 151 participants aged between 18-76 years old. The Symptom Assessment-45 Questionnaire via online was used to measure the severity of psychopathology symptoms. Socio-demographic, environmental and occupational variables were collected with an ad hoc questionnaire. The data were gathered from the 3rd to the 6th of April, 2020. A descriptive and comparative analysis was carried out using parametric contrasts (t test and ANOVA). RESULTS The younger participants (18-35 years) showed higher levels of hostility (t=2.24; p=0.02), depression (t=2.56; p=0.01), anxiety (t=2.78; p=0.006) and interpersonal sensitivity (t=2.08; p=0.04) than older participants (36-76 years). The active or employed people presented lower values of depressive symptoms (t=2.10; p=0.04) than unemployed people. The participants who dedicate less than 30 minutes on getting informed about COVID-19 showed higher scores for hostility (t=2.36; p=0.02) and interpersonal sensitivity (t=1.98; p=0.04) than participants who indicated dedicating at least 30 minutes. People who played sport daily reported a lower level of somatization symptoms (t=-2.11; p=0.03) than persons that did not play sport. Those who had relatives, acquaintances, etc. with COVID-19 reported higher levels of anxiety (t=2.09; p=0.04) than those who did not have close people infected. Lastly, participants who lived alone showed a higher level of psychoticism (F=3.93; p=0.02) compared to those who lived with more than two people. CONCLUSIONS The findings of this study show that during quarantine can be identified groups with higher psychological vulnerability based on sociodemographic and occupational-contextual factors. OBJETIVO La enfermedad pandémica por coronavirus (COVID-19) ha hecho necesaria la adopción de medidas de cuarentena en diferentes países. Estas medidas podrían tener un impacto sobre la salud mental de la población general en confinamiento. El objetivo del trabajo fue analizar las diferencias en la sintomatología psicopatológica mostrada por la población general española durante la cuarentena por COVID-19 en función de variables sociodemográficas, ambientales y ocupacionales. METODOS Se realizó un estudio trasversal en una muestra de 151 participantes, con edades comprendidas entre los 18 y los 76 años, en el que se utilizó de forma online la versión española del Symptom Assessment-45 Questionnaire para medir el nivel de síntomas psicopatológicos. Se recogieron también variables sociodemográficas, ambientales y de ocupación (mediante una encuesta ad hoc). La información fue recogida del 3 al 6 abril de 2020. Se realizó un análisis descriptivo y comparativo utilizando contrastes paramétricos (prueba t y ANOVA). RESULTADOS Los participantes más jóvenes (18-35 años) mostraron niveles más altos de hostilidad (t=2,24; p=0,02), depresión (t=2,56; p=0,01), ansiedad (t=2,78; p=0,006) y sensibilidad interpersonal (t=2,08; p=0,04) que los participantes mayores (36-76 años). Las personas activas o empleadas presentaron valores más bajos de síntomas depresivos (t=2,10; p=0,04) que las personas desempleadas. Los participantes que dedicaron menos de 30 minutos a informarse sobre el COVID-19 mostraron puntuaciones más altas en hostilidad (t=2,36; p=0,02) y sensibilidad interpersonal (t=1,98; p=0,04) que los participantes que indicaron dedicar al menos 30 minutos. Las personas que practicaban deporte diariamente informaron de un menor nivel de síntomas de somatización (t=-2,11; p=0,03) que las personas que no practicaban deporte. Aquellos que tenían familiares, conocidos, etc. con COVID-19 informaron de niveles más altos de ansiedad (t=2,09; p=0,04) que aquellos que no tenían a personas cercanas infectadas. Por último, los participantes que vivían solos mostraron un mayor nivel de psicoticismo (F=3,93; p=0,02) en comparación con aquellos que vivían con más de dos personas. CONCLUSIONES Los resultados de este estudio muestran que durante la cuarentena se pueden identificar grupos con mayor vulnerabilidad psicológica en función de factores sociodemográficos y ocupacionales-contextuales. AU - Becerra-García, Juan Antonio AU - Giménez Ballesta, Gala AU - Sánchez-Gutiérrez, Teresa AU - Barbeito Resa, Sara AU - Calvo Calvo, Ana KW - coronavirus KW - covid-19 KW - cuarentena KW - población KW - psicología KW - psicopatología KW - salud pública PY - 2020 TI - [Psychopathological symptoms during Covid-19 quarantine in spanish general population: a preliminary analysis based on sociodemographic and occupational-contextual factors.] T2 - Revista espanola de salud publica UR - http://www.ncbi.nlm.nih.gov/pubmed/32515363 VL - 94 ER - TY - JOUR AB - Objectives To provide a descriptive analysis of communities severely impacted by COVID-19 to that of communities moderately affected by COVID-19, with an emphasis on the social determinant factors within them. Methods To compare the communities with extremely high COVID-19 rates to that of communities with moderate COVID-19 cases, we selected six community districts in Queens, New York using public data from New York City Health Department that provides the percentage of positive COVID-19 cases by zip codes from March 1st, 2020 to April 17th, 2020. Results The results of the study showed that COVID-19 cases were 30% greater in communities with extremely high cases than in communities with moderate cases. There were also the several outstanding social determinants commonalities that were found in communities with extremely high COVID-19 cases. These include severe overcrowding, lower educational status, less access to healthcare, and more chronic diseases. Conclusion This study adds to existing literature on vulnerable urban communities affected by COVID-19. Future studies should focus on the underlying factors in each social determinant discussed in this study to better understand its association with the spread of COVID-19. AU - Harlem, Gunness DO - 10.1093/pubmed/fdaa078 IS - 3 KW - COVID-19 KW - Descriptive analysis KW - Health disparities KW - Severely affected communities KW - Social determinants PY - 2020 SP - 466 EP - 469 TI - Descriptive analysis of social determinant factors in urban communities affected by COVID-19 T2 - Journal of Public Health (United Kingdom) VL - 42 ER - TY - JOUR AB - This paper studies the dynamics of human mobility during the initial stage of the COVID-19 pandemic in countries around the world. The main goal of the analysis is to empirically separate voluntary reductions in mobility driven by the information about the location-specific pandemic trends from the effects of the government-imposed social distancing mandates. Google human mobility dataset is used to track the dynamics of mobility across a wide range of categories (e.g., workplace, retail and recreational activities, etc.), while information on country-specific counts of COVID-19 cases and deaths is used as a proxy for the information about the spread of the pandemic available to the population. A detailed index of stringency of the government-imposed social distancing policies in around 100 countries is used as a measure of government response. We find that human mobility does respond in a significant way to the information about the spread of the pandemic. This channel can explain about 15 percentage points of the overall reduction in mobility across the affected countries. At the same time, our results imply that government-imposed policies account for the majority of the reduction in the mobility observed during this period. AU - Mendolia, Silvia AU - Stavrunova, Olena AU - Yerokhin, Oleg DO - 10.1016/j.jebo.2021.01.023 KW - COVID-19 KW - Government response KW - Group fixed effects KW - Information KW - Mobility PB - Elsevier B.V. PY - 2021 SP - 199 EP - 231 TI - Determinants of the community mobility during the COVID-19 epidemic: The role of government regulations and information T2 - Journal of Economic Behavior and Organization UR - https://doi.org/10.1016/j.jebo.2021.01.023 VL - 184 ER - TY - JOUR AB - Background: Despite over 4 million cases of novel coronavirus disease 2019 (COVID-19) in the United States, limited data exist including socioeconomic background and post-discharge outcomes for patients hospitalized with this disease. Methods: In this case series, we identified patients with COVID-19 admitted to 3 Partners Healthcare hospitals in Boston, Massachusetts between March 7th, 2020, and March 30th, 2020. Patient characteristics, treatment strategies, and outcomes were determined. Findings: A total of 247 patients hospitalized with COVID-19 were identified; the median age was 61 (interquartile range [IQR]: 50–76 years), 58% were men, 30% of Hispanic ethnicity, 21% enrolled in Medicaid, and 12% dual-enrolled Medicare/Medicaid. The median estimated household income was $66,701 [IQR: $50,336-$86,601]. Most patients were treated with hydroxychloroquine (72%), and statins (76%; newly initiated in 34%). During their admission, 103 patients (42%) required intensive care. At the end of the data collection period (June 24, 2020), 213 patients (86.2%) were discharged alive, 2 patients (0.8%) remain admitted, and 32 patients (13%) have died. Among those discharged alive (n = 213), 70 (32.9%) were discharged to a post-acute facility, 31 (14.6%) newly required supplemental oxygen, 19 (8.9%) newly required tube feeding, and 34 (16%) required new prescriptions for antipsychotics, benzodiazepines, methadone, or opioids. Over a median post-discharge follow-up of 80 days (IQR, 68–84), 22 patients (10.3%) were readmitted. Interpretation: Patients hospitalized with COVID-19 are frequently of vulnerable socioeconomic status and often require intensive care. Patients who survive COVID-19 hospitalization have substantial need for post-acute services. AU - McCarthy, Cian P. AU - Murphy, Sean AU - Jones-O'Connor, Maeve AU - Olshan, David S. AU - Khambhati, Jay R. AU - Rehman, Saad AU - Cadigan, John B. AU - Cui, Jinghan AU - Meyerowitz, Eric A. AU - Philippides, George AU - Friedman, Lawrence S. AU - Kadar, Aran Y. AU - Hibbert, Kathryn AU - Natarajan, Pradeep AU - Massaro, Anthony F. AU - Bohula, Erin A. AU - Morrow, David A. AU - Woolley, Ann E. AU - Januzzi, James L. AU - Wasfy, Jason H. DO - 10.1016/j.eclinm.2020.100504 KW - COVID-19 KW - Outcomes research PB - Elsevier Ltd PY - 2020 SP - 100504 EP - 100504 TI - Early clinical and sociodemographic experience with patients hospitalized with COVID-19 at a large American healthcare system T2 - EClinicalMedicine UR - https://doi.org/10.1016/j.eclinm.2020.100504 VL - 26 ER - TY - JOUR AB - Hay estudios que permiten comprender aspectos relacionados a la Covid 19, pero no hay muchas publicaciones relativas a su impacto poblacional. Objetivo: Estudiar la relación de la letalidad y mortalidad con variables sociales, demográficas, económicas y de salud más relevantes durante los primeros 90 días de la pandemia en 60 países del mundo de los cuatro continentes. Material y métodos: Estudio transversal descriptivo y analítico de casos. Los casos lo conformaron 60 países seleccionados según la magnitud de su afectación por Covid 19. La mortalidad y la letalidad fueron estratificadas y se contrastaron con las variables de los países seleccionados mediante comparación de medias. Resultados: Se encontró una fuerte correlación entre la mortalidad y letalidad (r=0,70). El día en que se inició la enfermedad en un país y su crecimiento de infectados mostraron diferencias entre países: aquellos con mejores indicadores económicos e índice de desarrollo humano, tuvieron menos letalidad al inicio de la enfermedad. Al aumentar la incidencia, estas diferencias desaparecieron. Conclusión: Los resultados sugieren que al inicio de la enfermedad en un país, los mejores servicios son importantes, pero luego cuando la enfermedad ya se expandió, la incidencia es la variable más importante. Este resultado mostró que no hay recursos sanitarios que puedan disminuir la letalidad, independiente de cualquier otra característica del país afectado. AU - Cieza Zevallos, Javier AU - Uriol Lescano, Celene DO - 10.20453/rmh.v31i4.3852 IS - 4 KW - decs KW - economía KW - fuente KW - infecciones por coronavirus KW - mortalidad KW - sistemas de salud PY - 2021 SP - 214 EP - 221 TI - Letalidad y la mortalidad de Covid 19 en 60 países afectados y su impacto en los aspectos demográficos, económicos y de salud T2 - Revista Medica Herediana VL - 31 ER - TY - JOUR AB - In addition to top-down Health-Emergency and Disaster Risk Management (HealthEDRM) efforts, bottom-up individual and household measures are crucial for prevention and emergency response of the COVID-19 pandemic, a Public Health Emergency of International Concern (PHEIC). There is limited scientific evidence of the knowledge, perception, attitude and behavior patterns of the urban population. A computerized randomized digital dialing, cross-sectional, population landline-based telephone survey was conducted from 22 March to 1 April 2020 in Hong Kong Special Administrative Region, China. Data were collected for socio-demographic characteristics, knowledge, attitude and risk perception, and various self-reported Health-EDRM behavior patterns associated with COVID-19. The final study sample was 765. Although the respondents thought that individuals (68.6%) had similar responsibilities as government (67.5%) in infection control, less than 50% had sufficient health risk management knowledge to safeguard health and well-being. Among the examined Health-EDRM measures, significant differences were found between attitude and practice in regards to washing hands with soap, ordering takeaways, wearing masks, avoidance of visiting public places or using public transport, and travel avoidance to COVID-19-confirmed regions. Logistic regression indicated that the elderly were less likely to worry about infection with COVID-19. Compared to personal and household hygiene practices, lower compliance was found for public social distancing. AU - Chan, Emily Ying Yang AU - Huang, Zhe AU - Lo, Eugene Siu Kai AU - Hung, Kevin Kei Ching AU - Wong, Eliza Lai Yi AU - Wong, Samuel Yeung Shan DO - 10.3390/ijerph17113869 IS - 11 KW - Biological hazard KW - COVID-19 KW - Health risks KW - Health-emergency and disaster risk management KW - Hong Kong KW - PHEIC KW - Pandemic KW - Urban PY - 2020 SP - 1 EP - 18 TI - Sociodemographic predictors of health risk perception, attitude and behavior practices associated with health-emergency disaster risk management for biological hazards: The case of COVID-19 pandemic in Hong Kong, SAR China T2 - International Journal of Environmental Research and Public Health VL - 17 ER - TY - GEN TI - Secretaría de Planeación UR - http://www.cundinamarca.gov.co/Home/SecretariasEntidades.gc/Secretariadeplaneacion/SecretariadeplaneacionDespliegue/aspoliyplanprog_contenidos/csecreplanea__plandesarrdep_2020_2023 ER - TY - GEN AU - Ministerio de la proteccion social TI - El Coronavirus en Colombia UR - https://coronaviruscolombia.gov.co/Covid19/index.html ER - TY - GEN AB - Attention mechanisms play a central role in NLP systems, especially within recurrent neural network (RNN) models. Recently, there has been increasing interest in whether or not the intermediate representations offered by these modules may be used to explain the reasoning for a model's prediction, and consequently reach insights regarding the model's decision-making process. A recent paper claims that 'Attention is not Explanation' (Jain and Wallace, 2019). We challenge many of the assumptions underlying this work, arguing that such a claim depends on one's definition of explanation, and that testing it needs to take into account all elements of the model. We propose four alternative tests to determine when/whether attention can be used as explanation: a simple uniform-weights baseline; a variance calibration based on multiple random seed runs; a diagnostic framework using frozen weights from pretrained models; and an end-to-end adversarial attention training protocol. Each allows for meaningful interpretation of attention mechanisms in RNN models. We show that even when reliable adversarial distributions can be found, they don't perform well on the simple diagnostic, indicating that prior work does not disprove the usefulness of attention mechanisms for explainability. AU - Ministerio de saludy proteccion social SP - 148 EP - 162 TI - Plan Decenal de Salud Pública-PDSP 2012-2021 VL - 148 ER - TY - GEN AU - Presidencia de la republica PY - 2021 SP - 1 EP - 16 TI - Decreto 1168 de 2020 ER - TY - JOUR AU - Backer, Jantien A AU - Klinkenberg, Don AU - Wallinga, Jacco KW - 18yjc910017 KW - 1988 KW - 2018qn021 KW - 2020-07-12 KW - 2020-08-07 KW - 61802339 KW - 61872314 KW - a2001 KW - cg 国家重点实验室开放课题 KW - interactions KW - lgf20f020010 KW - lgf20g010003 KW - ly18f020024 KW - multi-dimensional attributes KW - multivariate network KW - network structure KW - visual analytics KW - 修回日期 KW - 关 计 划 项 KW - 刘玉华 KW - 国家自然科学基金 KW - 基金项目 KW - 技 厅 公 益 KW - 收稿日期 KW - 教育部人文社会科学研究 KW - 文 社 科 攻 KW - 校 重 大 人 KW - 浙 江 省 科 KW - 浙 江 省 高 KW - 浙江大学 cad KW - 浙江省自然科学基金 KW - 男 KW - 目 KW - 项 目 PY - 2020 SP - 1 EP - 13 TI - The incubation period of 2019-nCoV infections among travellers from Wuhan, China T2 - medRxiv VL - 32 ER - TY - JOUR AB - Resumen de la situación Desde la Alerta Epidemiológica sobre el nuevo coronavirus (2019-nCoV) publicada el 16 de enero de 2020 (disponible en: https://bit.ly/3alZAxe) y hasta al 20 de enero de 2020 cuatro países en total han reportado a la Organización Mundial de la Salud (OMS) casos confirmados: China (198 casos en Wuhan, incluidas tres defunciones, 2 casos en Beijing y un caso en Guandong, los tres importados de Wuhan), Japón (1 caso, importado desde Wuhan, China), Tailandia (dos casos importados desde Wuhan, China) y la República de Corea (1 caso importado de Wuhan, China). Respuesta de salud pública y evaluación de riesgos para las Américas De acuerdo con la información divulgada por las autoridades chinas, una investigación epidemiológica dirigida por un equipo nacional de expertos comenzó el 31 de diciembre de 2019 y fueron implementadas las siguientes medidas de salud pública: aislamiento de casos, identificación y seguimiento de contactos, saneamiento ambiental e investigación de laboratorio. A la fecha, continua la incertidumbre sobre el nuevo patógeno y el espectro de manifestaciones que pueda causar, la fuente de infección, el modo de transmisión, el periodo de incubación, la gravedad de la enfermedad y las medidas específicas de control. La evidencia actual sugiere que la transmisión de persona a persona es limitada, lo cual sería consistente con lo que se conoce sobre otros patógenos similares. En particular, la transmisión de persona a persona, incluido en el entorno nosocomial, ha sido documentada para otros coronavirus emergentes, como el Síndrome respiratorio agudo severo (SARS) y el Coronavirus causante del síndrome respiratorio de Oriente Medio (MERS-CoV). Por ende, las medidas de control tomadas para SARS y MERS pueden guiar interinamente a la repuesta contra este nuevo patógeno. La OMS ha preparado un paquete técnico que se actualiza periódicamente para informar y apoyar a los Estados Miembros. La información (en inglés) se puede acceder a través del siguiente enlace: https://www.who.int/health-topics/coronavirus AU - Organización Mundial de la Salud AU - Organización Panamericana de Salud IS - Cdc PY - 2020 SP - 1 EP - 10 TI - Actualización Epidemiológica T2 - Organización Mundial de la Salud UR - https://www.paho.org/sites/default/files/2020-02/2020-feb-28-phe-actualizacion-epi-covid19.pdf VL - 2019 ER - TY - JOUR AB - HIGHLIGHTS • WHO Director-General Dr Tedros Adhanom Ghebreyesus and colleagues are in Beijing to meet with government and health experts supporting the response. The mission’s aim is to understand the latest developments and strengthen the partnership with China, in particular for the response. • Current estimates of the incubation period of the virus range from 2-10 days, and these estimates will be refined as more data become available. Understanding the time when infected patients may transmit the virus to others is critical for control efforts. Detailed epidemiological information from more people infected is needed to determine the infectious period of 2019- nCoV, in particular whether transmission can occur from asymptomatic individuals or during the incubation period. WHO requests countries to notify WHO of cases following the guidance included in: https://www.who.int/publications-detail/global-surveillance-forhuman-infection-with-novel-coronavirus-(2019-ncov) • WHO is continually monitoring developments and on standby to reconvene the Emergency Committee on very short notice as needed. Committee members are regularly informed of developments. AU - World Health Organization (WHO) IS - JANUARY PY - 2020 SP - 1 EP - 7 TI - Novel Coronavirus situation report 7 ( 2019-nCoV ) T2 - WHO Bulletin ER - TY - JOUR AU - Gobernacion de Cundinamarca PY - 2012 SP - 166 EP - 166 TI - Plan Territorial de salud 2012 2015 UR - www.cundinamarca.gov.co ER - TY - BOOK AB - Attention mechanisms play a central role in NLP systems, especially within recurrent neural network (RNN) models. Recently, there has been increasing interest in whether or not the intermediate representations offered by these modules may be used to explain the reasoning for a model's prediction, and consequently reach insights regarding the model's decision-making process. A recent paper claims that 'Attention is not Explanation' (Jain and Wallace, 2019). We challenge many of the assumptions underlying this work, arguing that such a claim depends on one's definition of explanation, and that testing it needs to take into account all elements of the model. We propose four alternative tests to determine when/whether attention can be used as explanation: a simple uniform-weights baseline; a variance calibration based on multiple random seed runs; a diagnostic framework using frozen weights from pretrained models; and an end-to-end adversarial attention training protocol. Each allows for meaningful interpretation of attention mechanisms in RNN models. We show that even when reliable adversarial distributions can be found, they don't perform well on the simple diagnostic, indicating that prior work does not disprove the usefulness of attention mechanisms for explainability. AU - Departamento nacional de planeación SN - 9789588340883 SP - 148 EP - 162 TI - Plan Nacional de Desarrollo 2015 – 2018 VL - 148 ER - TY - JOUR AU - Secretaría de Salud de Cundinamarca PY - 2021 SP - 56 EP - 56 TI - Plan Territorial de Salud 2020-2023 ER - TY - JOUR AU - Cundinamarca, Gobernacion de PY - 2016 TI - Plan Territorial de Salud 2016-2020 UR - http://www.cundinamarca.gov.co/wcm/connect/05f0e3ba-d5fc-47d9-a589-7818bc13190b/1PTS+con+PASE+CUNDINAMARCA+v14.pdf?MOD=AJPERES&CVID=llgaL7u ER - TY - JOUR AB - Conferencia Internacional sobre Atención Primaria de Salud, Alma-Ata, URSS, 6-12 de septiembre de 1978 AU - The Pan American Health Organization PY - 2012 SP - 8 EP - 10 TI - Declaracion De Alma-Ata T2 - Conferencia Internacional sobre Atención Primaria de Salud, Alma-Ata, URSS, 6-12 de septiembre de 1978 UR - https://www.paho.org/hq/dmdocuments/2012/Alma-Ata-1978Declaracion.pdf ER - TY - JOUR AB - Resumen El presente escrito pretende dar cuenta de la pérdida del estatuto epistemológico propio de la filosofía tal como lo establecieron sus primeros cultores: los griegos. Esta pérdida reconoce, como primer momento, el pensamiento de Kant quien reduce la filosofía a epistemología. Un segundo momento lo constituye el pensamiento de Marx para quien la filosofía deja de ser comprensión para pasar a ser revolución. Esta última desemboca en un nihilismo en cuyo horizonte de comprensión la filosofía es entendida en términos de ideología, incluido el intento hermenéutico. La recuperación del auténtico estatuto epistemológico de la filosofía dependerá de la docilidad del espíritu humano en probar algo (experiri) que se nombra ser. Abstract This paper aims to explain the loss of Philosophy's epistemic status as it was first established by the Greeks. This loss was first operated by Kant, who reduced Philosophy to Epistemology; and later, by Marx, for whom Philosophy ceased to be understanding to become revolution. This latter leads to a Nihilism that understands Philosophy in terms of an ideology, including the hermeneutical intent. The recovery of the genuine epistemic status of Philosophy will depend on the docility of the human spirit in proving something (experiri) named being. AU - Lasa, Carlos Daniel KW - Filosofía KW - HUMANIDADES KW - Ideología KW - Kant KW - Marx KW - Otras Filosofía KW - info:ar-repo/semantics/artículo KW - info:eu-repo/semantics/article KW - info:eu-repo/semantics/publishedVersion KW - Ética y Religión KW - Étnica y Religión PY - 2016 SP - 21 EP - 33 TI - El conocimiento filosófico y una historia de amenazas T2 - Cuadernos Universitarios VL - 7124 ER - TY - JOUR AB - La filosofía y ~u historia están in- trínsecamente enlazadas. La historia de lafiloso- fía es, al mismo tiempo, una ciencia positiva y un saber filosófico, pero difieren en cuanto al nivel de comprensión. Pero mas que una parte de un sistema total que se desarrolla en el tiempo, las obras filosóficas del pasado son una invitación al diálogo AU - Mora, Arnoldo IS - 101 PY - 2002 SP - 251 EP - 251 TI - Filosofía e historia de la Biología T2 - Rev. Filosofía Univ. Costa Rica. VL - XL ER - TY - JOUR AU - Durán Casas, Vicente KW - info:eu-repo/semantics/article KW - info:eu-repo/semantics/publishedVersion KW - null PY - 2005 SP - 187 EP - 199 TI - Concepto y práctica de la historia de la filosofía T2 - Universitas philosophica VL - 44 ER - TY - JOUR AU - Galzacorta, Iñigo IS - 76 KW - about what read- KW - abstract KW - actualidad KW - aim KW - by discussing some of KW - hermenéutica KW - historia del ser KW - historiografía de la filosofía KW - history of philosophy means KW - ing texts from the KW - ontología de la KW - the most prevalent views KW - this paper explores the PY - 2000 SP - 35 EP - 46 TI - La historia de la filosofía como tarea filosófica. Consideraciones a partir de Heidegger T2 - Diánoia VL - LXI ER - TY - JOUR AB - En esta época de la publicación de Diánoia no se incluían resúmenes. AU - Fernández Viejo, Salustiano DO - 10.22201/iifs.18704913e.1988.34.677 IS - 34 PY - 1988 SP - 206 EP - 206 TI - Filosofía e historia de la filosofía T2 - Revista de filosofía DIÁNOIA VL - 34 ER - TY - JOUR AU - Bronislawa Duda, Marta DO - 10.2307/j.ctv47wdwz.4 KW - historia KW - historiografía KW - nueva historia política KW - política KW - teoría de la historia PY - 2018 SP - 21 EP - 42 TI - La Historia politica T2 - Iberoamérica ER - TY - BOOK AU - Belvedresi, Rosa E CY - La Plata KW - Filosofía de la Historia PY - 2016 SP - 79 EP - 79 TI - Introducción a la filosofía de la historia: Conceptos y teorías de la historia ER - TY - JOUR AU - Monsalve, Luz marina AU - Castrillon Zapata, Fernando PY - 2008 SP - 91 EP - 98 TI - La Conexión vial Las ánimas - Nuquí, ¿una salida al mar del Pacífico, a cualquier precio? T2 - Revista Semillas UR - https://www.semillas.org.co/es/la-conexin-vial-las-nimas-nuqu-una-salida-al-mar-del-pacfico-a-cualquier-precio# VL - 36-37 ER - TY - GEN AB - (julio 13) Diario Oficial No 43.340, del 15 de julio de 1998. MINISTERIO DEL INTERIOR Por el cual se reglamenta la consulta previa con las comunidades indígenas y negras para la explotación de los recursos naturales dentro de su territorio. EL PRESIDENTE DE LA REPUBLICA DE COLOMBIA, en uso de sus atribuciones constitucionales y legales, en especial de las que le confiere el numeral 11 del artículo 189 y el parágrafo del artículo 330 de la Constitución Política, en desarrollo de lo dispuesto en el numeral 2o. del artículo 15 de la Ley 21 de 1991, en el artículo 44 de la Ley 70 de 1993 y en el artículo 76 de la Ley 99 de 1993, CONSIDERANDO: Que el artículo 7o. de la Constitución Política señala que: "El Estado reconoce y protege la diversidad étnica y cultural de la Nación colombiana": Que el parágrafo del artículo 330 de la Constitución Política establece: "La explotación de los recursos naturales en los territorios indígenas se hará sin desmedro de la integridad cultural, social y económica de las comunidades indígenas. En las decisiones que se adopten respecto de dicha explotación el gobierno propiciará la participación de los representantes de las respectivas comunidades". Que el numeral 3o. del artículo 7o. de la Ley 21 de 1991, por la cual se aprueba el Convenio No. 169 de 1987 de la OIT sobre pueblos indígenas y tribales, dispone que: "Los gobiernos deberán velar porque, siempre que haya lugar, se efectúen estudios, en cooperación con los pueblos interesados, a fin de evaluar la incidencia social, espiritual y cultural y sobre el medio ambiente que las actividades de desarrollo previstas puedan tener sobre esos pueblos. Los resultados de estos estudios deberán ser considerados como criterios fundamentales para la ejecución de las actividades mencionadas". Que igualmente, el numeral 2 del artículo 15 de la Ley 21 de 1991 establece que: "En caso de que pertenezca al Estado la propiedad de los minerales o recursos del subsuelo, o tenga derechos sobre otros recursos existentes en las tierras, los gobiernos deberán establecer o mantener procedimientos con miras a consultar a los pueblos interesados, a fin de determinar si los intereses de esos pueblos serían perjudicados y en qué medida, antes de emprender o autorizar cualquier programa de prospección o explotación de los recursos existentes en sus tierras..". Que el artículo 17 de la Ley 70 de 1993 preceptúa que a partir de su vigencia y hasta tanto no se haya adjudicado en debida forma la propiedad colectiva a una comunidad negra que ocupe un terreno en los términos que la misma establece, no se adjudicarán las tierras ocupadas por dicha comunidad ni se otorgarán autorizaciones para explotar en ella recursos naturales, sin concepto previo de la Comisión conformada por el Instituto Colombiano para la Reforma Agraria, AU - Ministerio del Interior PY - 1998 SP - 9 EP - 9 TI - Decreto 1320 DE 1998 ER - TY - GEN AU - Consejo Nacional de Politica economica y social PY - 2005 TI - Conpes 3389 ER - TY - JOUR AU - Secretaria de Salud Departamental PY - 2021 TI - Actualización Análisis de Situación de Salud (ASIS) 2020 con el Modelo De los Determinantes Sociales de Salud: Departamento del Chocó T2 - Ministerio de Salud y Protección Social ER - TY - JOUR AB - Dónde se trata de las consideraciones concernientes a un proyecto geométrico de una carretera. Se documentaron 5 componentes básicos: localización, diseño geométrico, pavimentos, pasos a desnivel y seguridad. Se hace mención a la metodología para la composición documental para generar un proyecto geométrico de carreteras. AU - León, Jorge A Montaño De AU - León, David Zúñiga De AU - Alberto, Mtro AU - Esparza, Rodríguez IS - 57 KW - Proyecto geométrico KW - carretera PY - 2015 SP - 42 EP - 52 TI - Consideraciones, procedimientos y conceptos para la realización de un proyecto geométrico de carreteras T2 - Cultura Científica y Tecnológica VL - 0 ER - TY - JOUR AB - Predicting the binding mode of flexible polypeptides to proteins is an important task that falls outside the domain of applicability of most small molecule and protein−protein docking tools. Here, we test the small molecule flexible ligand docking program Glide on a set of 19 non-α-helical peptides and systematically improve pose prediction accuracy by enhancing Glide sampling for flexible polypeptides. In addition, scoring of the poses was improved by post-processing with physics-based implicit solvent MM- GBSA calculations. Using the best RMSD among the top 10 scoring poses as a metric, the success rate (RMSD ≤ 2.0 Å for the interface backbone atoms) increased from 21% with default Glide SP settings to 58% with the enhanced peptide sampling and scoring protocol in the case of redocking to the native protein structure. This approaches the accuracy of the recently developed Rosetta FlexPepDock method (63% success for these 19 peptides) while being over 100 times faster. Cross-docking was performed for a subset of cases where an unbound receptor structure was available, and in that case, 40% of peptides were docked successfully. We analyze the results and find that the optimized polypeptide protocol is most accurate for extended peptides of limited size and number of formal charges, defining a domain of applicability for this approach. AU - Amparo, Gloria IS - 9 KW - icle PY - 2008 SN - 9788578110796 SP - 63 TI - La consulta previa, un derecho fundamental de los pueblos indígenas y grupos étnicos de Colombia T2 - Semillas Revistas UR - https://www.semillas.org.co/es/revista/la-consulta-previa-un-derecho-fundamental-de-los-pueblos-indgenas-y-grupos-tnicos-de-colombia VL - 34-37 ER - TY - JOUR AB - Las vías Secundarias y Terciarias juegan un papel importante en la integración nacional, regional y local, y además facilitan el acceso a la vida nacional de comunidades remotas y aisladas. Estas vías en su conjunto, representan cerca del 92% del total de la malla vial nacional. Este artículo señala algunos puntos que deben considerarse durante la planeación y ejecución de la infraestructura vial secundaria y terciaria, importante si el Gobierno Nacional quiere materializar el posconflicto en el país rural. AU - Ospina, Germán DO - 10.16924/riua.v0i44.911 IS - 44 KW - Vías secundarias, vías terciarias, infraestructura KW - infraes- KW - inversión estatal KW - posconflicto KW - tructura vial KW - vías secundarias KW - vías terciarias PY - 2016 SP - 20 EP - 20 TI - El papel de las vías secundarias y los caminos vecinales en el desarrollo de Colombia T2 - Revista de Ingeniería VL - 0 ER - TY - JOUR AB - Las vías Secundarias y Terciarias juegan un papel importante en la integración nacional, regional y local, y además facilitan el acceso a la vida nacional de comunidades remotas y aisladas. Estas vías en su conjunto, representan cerca del 92% del total de la malla vial nacional. Este artículo señala algunos puntos que deben considerarse durante la planeación y ejecución de la infraestructura vial secundaria y terciaria, importante si el Gobierno Nacional quiere materializar el posconflicto en el país rural. AU - Ospina, Germán DO - 10.16924/riua.v0i44.911 IS - 44 KW - infraes- KW - inversión estatal KW - posconflicto KW - tructura vial KW - vías secundarias KW - vías terciarias PY - 2016 SP - 20 EP - 20 TI - El papel de las vías secundarias y los caminos vecinales en el desarrollo de Colombia T2 - Revista de Ingeniería VL - 0 ER - TY - JOUR AB - The aim of this article is to show some territorial conflicts caused by the recent implementation of road infrastructure projects in Colombia. The look is made from the field of the land management approach, this point of view, allow us understands how the complex reality intertwine in the territory, involving multiple dimensions, times and scales, making it necessary to identify different levels of analysis, correlations and interdependencies. To achieve this, we take as a universe of analysis the top ten projects pathways Fourth Generation, 4G, and some examples of other routes previously built under the concession scheme method, in order to extract from them some evidence about the impacts and generated conflict types. Research and insights drawn from it are based on variables of economic, social, environmental, demographic and historical nature, some drawn from literature and other sources dialogue with the habitants. With a possible scenario o armed conflicto end, in our conclusión, we propose some reflections on the role that this type of infrastructure would play on that stage. AU - Rincón-Avellaneda, María Patricia DO - 10.15446/bitacora.v26n2.59292 IS - 2 KW - 4G roads KW - Peace agreements KW - Perimeter east KW - Territorial conflicts KW - Territorial dynamics PY - 2016 SP - 71 EP - 78 TI - Conflictos territoriales y proyectos de infraestructura vial T2 - Bitacora Urbano Territorial VL - 26 ER - TY - JOUR AU - Gómez Lizarazo, jairo Alberto AU - Serna Uran, Conrado Augusto AU - Arango Serna, Martin Darío IS - 25 KW - assessment of logistics KW - colombia KW - corridor road infrastructure in KW - desgaste de pavimentos KW - dinámica de sistemas KW - dynamic model for quality KW - estado de KW - índice de rugosidad internacional PY - 2016 SP - 135 EP - 145 TI - Modelo de evaluación dinámica de la calidad en la infraestructura vial de corredores logísticos en Colombia T2 - Revista EIA VL - 13 ER - TY - JOUR AB - El indígena precolombino desarrolló en grado variable la capacidad de desafiar y ejecutar obras en el ramo vial. Para el caso que concierne, se señalan como las más importantes, la construcción de distintas clases de puentes y la de embarcaciones. Asimismo, los caminos que van en línea recta cualquiera que sea la pendiente, se explican por la necesidad de llegar cuanto antes a un punto determinado, pues siendo gente de a pie y ágil, la pendiente no representaba obstáculo. Antes, hubo caminos... Anduvieron los precolombinos comerciando intercambiando “trueque” más que imponiendo una lengua común. Por haber desarrollado sus civilizaciones sobre las cordilleras, su arte de construir trochas y puentes, de llegar a mercados distantes escalando montes y cruzando ríos los llevó a hacer puentes de bejucos, y a empedrar caminos y hacer escaleras tan perfectas como las de los taironas, y a cruzar provincias de lenguas diversas como en los largos caminos reales que recorrían los chasquis incas yendo de tambo en tambo a velocidad de mulas, como ocurría también entre los aztecas. AU - Osorio Baquero, Ismael IS - 17 KW - Colombia. KW - caminos precolombinos KW - carreteras nacionales KW - vías férreas PY - 2014 SP - 183 EP - 187 TI - Breve reseña histórica de las vías en Colombia T2 - Ingeniería Solidaria UR - https://revistas.ucc.edu.co/index.php/in/article/download/880/777/ VL - 10 ER - TY - GEN AB - cesiones o proyectos viales que tienen como finalidad mejorar la movilidad en Colombia y promover la competitividad y el desarrollo del País. El presente proyecto consiste en dar solución a la siguiente problemática: ¿Cómo impactará económica y socialmente la ejecución de las vías 4G a Colombia? Para darle respuesta al problema planteado, se tomaron como referencias académicas: aportes de diferentes fuentes informativas como periódicos, revistas del mundo de la economía, tesis académicas que aportaron gran valor a la investigación, además de publicaciones indexadas como también voces de expertos de entidades públicas y privadas, que brindaron una mayor visión y claridad del tema a investigar. Vale la pena destacar, que uno de los hallazgos más importantes encontrados durante todo el desarrollo del proyecto, tiene que ver con el estado de las vías de Colombia, a raíz de esto la competitividad colombiana se ha visto seriamente afectada. Según las encuestas que se realizaron a expertos, 9 de los 11 encuestados consideran que todas las clases sociales se verán sumamente beneficiadas con el proyecto de las vías 4G. También se encontró que el 66% de los encuestados cree que Colombia estará dentro de los 3 países más competitivos de América Latina en el ámbito de la logística internacional después de finalizar la construcción de estas importantes obras. AU - Martinez Rendon, Julian Alexis AU - Sanchez Gonzalez, Felipe KW - Competitividad KW - Desarrollo KW - Desarrollo Económico y Social. KW - Infraestructura KW - Inversión KW - Movilidad KW - Vías 4G PY - 2017 SP - 88 EP - 88 TI - Impactos económicos y sociales de las vías 4G en Colombia ER - TY - GEN AB - ΕΙΣ ΤΟΝ ΑΙΩΝΑ AU - Riaño Velasquez, Brian Andres AU - Ramirez Hernandez, Sebastian Felipe IS - 5 KW - ΕΡΨΣ-ΑΓΑΠΗ PY - 2019 SP - 55 EP - 55 TI - Diagnostico de las vías primarias en Colombia y la intervencion de la Ingenieria civil para su ejecución y mantenimiento T2 - Universidad Catolica de Colombia VL - 8 ER - TY - GEN AU - Montagut Meneses, Jaime Luis AU - Patiño Quiroga, Carlos Miguel IS - 7 KW - e-banking services KW - e-commerce KW - islamic and conventional banks KW - saudi PY - 2015 SP - 59 EP - 78 TI - El impacto de los proyectos de infraestructura vial en los aspectos socieconomicos y los cambios en los valores del terreno en una zona en del departamento del Cesar VL - 3 ER - TY - JOUR AB - ΕΙΣ ΤΟΝ ΑΙΩΝΑ AU - Archila, Andres Vicente AU - Aparicio, Maria Fernanda AU - Husada, Fajar Robert Khoirul AU - Martínez, German AU - Soemari, Yulistia Budianti AU - Sapri AU - Maghfiroh, Fika AU - Yuniarti, Achaditani, Nani Murniati AU - Variani, Ratih AU - Tsabitah, Amira Fawwaz AU - Zulkarnain, Abdul Karim AU - Wahyuningsih, Mae Sri Hartanti AU - Nugrahaningsih, Dwi Aris Agung AU - Akmaliyah, Mela AU - Syamsul, Eka Siswanto AU - Amanda, Nadhila Ajrina AU - Lestari, Dwi AU - 2021, scmidt iotc AU - Sumule, Arsiaty AU - Kuncahyo, Ilham AU - Leviana, Fransiska AU - Xue-, Wang AU - Kimia, Jurusan Teknik AU - Malang, Politeknik Negeri AU - Soekarno, Jl AU - No, Hatta AU - Rosidah, Nor Azizatur AU - Erlita, Isyana AU - N., M.Yanuar Ichrom AU - Farmasi, Dosen AU - Analis, Akademi AU - Aceh, Banda AU - Farmasi, Mahasiswa D AU - Farmasi, Akademi AU - Aceh, Pemerintah AU - Aceh, Banda AU - Analis, Rinaldi AU - Banda, Makanan AU - Cik, Jalan T AU - No, Ditiro AU - Grha, Gedung AU - Riani, Meiyestri Dwi AU - Oenzil, Fadil AU - Kasuma, Nila AU - Perdani, Annisa Putri AU - Oktarlina, Rasmi Zakiah AU - Jausal, Anisa Nuraisa AU - Access, Open AU - Maulina, Lena AU - Sugihartini, Nining AU - Redaksi, . AU - Han, Eunice S. AU - goleman, daniel; boyatzis, Richard; Mckee, Annie AU - Mariani, Sri AU - Rahman, Nurdin AU - Supriadi, Supriadi AU - Magfiroh, Siti AU - Sunarmo, Agus AU - Primasari, Dona AU - Setyawati, Any AU - Nur, Syifa Nabila Farah Fauziah AU - Seminar, Prosiding AU - Penelitian, Nasional AU - Hasani, Ruslan AU - Prodi, Dosen AU - Kimia, Teknik AU - Teknik, Fakultas AU - Bosowa, Universitas AU - Politeknik, Dosen AU - Makassar, Kesehatan AU - Prodi, Mahasiswa AU - Kimia, Teknik AU - Teknik, Fakultas AU - Bosowa, Universitas AU - Januarizqi, Kevinda AU - Erlita, Isyana AU - Diana, Sherli AU - Irwandana, Praditya Wisang AU - Kristanti, Yulita AU - Daradjati, Sri AU - Irianto, Iramie Duma Kencana AU - Purwanto, Purwanto AU - Mardan, Marwan Triafrian AU - Hidayah, Aimatul AU - Redjeki, Sri AU - Gunawan, Harun Asyiq AU - Wijaya, K. C. AU - Soufyan, A. AU - Irawan, B. AU - Matram, N. AU - Hermansah, Hermansah AU - Tooth-whitening, Pemutihan Gigi AU - Gigi, Pada AU - Mengalami, Yang AU - Nikhla, Saelin AU - Nuraeni, Afik AU - Ulfatunnisa, Fauziyah AU - Sayuti, Nutrsia Aquariushinta AU - Fibryanto, Eko AU - Gasc, Antonio AU - B, Andrea Nardini AU - B, Sebastiano Salleo AU - Fr, Tours AU - Steven, D AU - Moreira, Samuel D Sandro L.S. AU - França, André C AU - Rocha, Wellington W AU - Tibães, Evandro S R AU - Júnior, Eudes Neiva AU - Martins, Samuel C.V. Cordeiro Vitor AU - Araújo, Wagner L. AU - Tohge, Takayuki AU - Fernie, Alisdair R. AU - DaMatta, F.M. Fabio Fábio Murilo Fabio M Fábio Murilo Fabio M. AU - Hibberd, Julian M. AU - Weber, Andreas P. M. AU - Tokumura, Masahiro AU - Ohta, Ayano AU - Znad, Hussein Tawfeek AU - Kawase, Yoshinori AU - Praxedes, Sidney C. AU - DaMatta, F.M. Fabio Fábio Murilo Fabio M Fábio Murilo Fabio M. AU - Loureiro, Marcelo Ehlers AU - Maria, Maria A. AU - Cordeiro, Antônio T. AU - Alves, Jose Donizeti José Donizeti AU - Paglis, Carlos Maurício AU - Livramento, Darlan Einstein do AU - Linhares, Suellen Sarah Drumond AU - Becker, Frederico Biagi AU - Mesquita, Alessandro Carlos AU - Liu, Chujiao AU - Yang, Qian AU - Linforth, Robert AU - Fisk, Ian D. AU - Yang, Ni AU - Kiyingi, I AU - Vaast, Philippe AU - Bertrand, Benoit Benóit AU - Perriot, Jean Jacques AU - Guyot, Bernard AU - Génard, Michel AU - بخت, محمد حسین ناصر AU - Blackman, G E AU - Rutter, A J AU - Pearcy, F. Valladares \& R. W. AU - Valladares AU - C. Schmitt and U. Grote AU - DaMatta, F.M. Fabio Fábio Murilo Fabio M Fábio Murilo Fabio M. AU - Cunha, Roberto L. AU - Antunes, Werner Camargos AU - Martins, Samuel C.V. Cordeiro Vitor AU - Araujo, Wagner L. AU - Fernie, Alisdair R. AU - Moraes, Gustavo A.B.K. AU - Abbas, Munawar AU - Saeed, Farhan AU - Anjum, Faqir Muhammad AU - Afzaal, Muhammad AU - Tufail, Tabussam AU - Bashir, Muhammad Shakeel AU - Ishtiaq, Adnan AU - Hussain, Syed Ammar Shahzad AU - Suleria, Hafiz Ansar Rasul AU - Dhand, Vivek AU - Soumya, L AU - Bharadwaj, S AU - Chakra, Shilpa AU - Bhatt, Deepika AU - Sreedhar, B AU - Unigarro-Muñoz, Carlos Andrés AU - Hernández-Arredondo, Juan David AU - Montoya-Restrepo, Esther Cecilia AU - Medina-Rivera, Ruben Darío AU - Ibarra-Ruales, Lizardo Norbey AU - Carmona-González, Claudia Yoana AU - Flórez-Ramos, Claudia Patricia AU - Franck, Nicolás AU - Vaast, Philippe AU - Génard, Michel AU - Dauzat, Jean AU - Tahjib-Ul-Arif, Md AU - Siddiqui, Md Nurealam AU - Sohag, Abdullah Al Mamun AU - Sakil, Md Arif AU - Rahman, Md Mezanur AU - Polash, Mohammed Arif Sadik AU - Mostofa, Mohammad Golam AU - Tran, Lam Son Phan AU - Campos, Paula Scotti AU - Quartin, Virgínia L. AU - Ramalho, José Cochicho Jose C J.C. José C. Domingos Cochicho AU - Nunes, Maria Antonieta AU - Davis, Aaron P AU - Corley, R. H.V. AU - Cruz, Rebeca AU - Gomes, Teresa AU - Ferreira, Anabela AU - Mendes, Eulália AU - Baptista, Paula AU - Cunha, Sara AU - Pereira, José S. Alberto AU - Ramalhosa, Elsa AU - Casal, Susana AU - Mohd, Ahmad Nazarudin AU - Tsan, Roseli AU - Ying, Fui AU - Osman, Normaniza AU - Othman, Roohaida AU - Ding, Phebe AU - Hajar, Siti AU - Aishah, Ahmad Siti AU - Puteri, Hassan AU - Megat, Edaroyati AU - Hazandy, Wahab AU - Hamid, Abdul AU - Eng, Lok AU - Soetanto, Hai AU - Prawoto, Abdoellah A Adi AU - Bako, John AU - Md, Baon AU - Jahan, Sarwar AU - Janssen, Paul J. D. AU - Lambreva, Maya D. AU - Plumeré, Nicolas AU - Bartolucci, Cecilia AU - Antonacci, Amina AU - Buonasera, Katia AU - Frese, Raoul N. AU - Scognamiglio, Viviana AU - Rea, Giuseppina AU - Bunn, Christian AU - LÄderach, Peter AU - Jimenez, Juan Guillermo Pérez AU - Montagnon, Christophe AU - Schilling, Timothy AU - Kumar, Avinash AU - Simmi, P S AU - Naik, Gyanendra Kumar AU - Giridhar, Parvatam AU - Hossain, Mohammad Anwar AU - Wani, Shabir Hussain AU - Bhattacharjee, Soumen AU - Burritl, David J. AU - Tran, Lam Son Phan AU - Pinheiro, Hugo A. AU - Reis, André Rodrigues AU - Favarin, José Laércio AU - Malavolta, Eurípedes AU - Júnior, José Lavres AU - Moraes, Milton Ferreira AU - Ribeiro, Rafael Vasconcelos AU - Machado, E. C. AU - Oliveira, R. F. AU - Ort, Donald R. AU - Merchant, Sabeeha S. AU - Alric, Jean AU - Barkan, Alice AU - Blankenship, Robert E. AU - Bock, Ralph AU - Croce, Roberta AU - Hanson, Maureen R. AU - Hibberd, Julian M. AU - Long, Stephen P. AU - Moore, Thomas A. AU - Moroney, James AU - Niyogi, Krishna K. AU - Parry, Martin A.J. J. AU - Peralta-Yahya, Pamela P. AU - Prince, Roger C. AU - Redding, Kevin E. AU - Spalding, Martin H. AU - van Wijk, Klaas J. AU - Vermaas, Wim F. J. AU - von Caemmerer, Susanne AU - Weber, Andreas P. M. AU - Yeates, Todd O. AU - Yuan, Joshua S. AU - Zhu, Xin Guang AU - Petermann, Joseph B AU - Baumann, Thomas W AU - Badr, Ashraf AU - Angers, Paul AU - Desjardins, Yves AU - Ramalho, José Cochicho Jose C J.C. José C. Domingos Cochicho AU - Fortunato, Ana S. A.S. Ana S. AU - Rodrigues, Ana P. A.P. P. AU - Martins, Madlles Q. M.Q. Q AU - Rodrigues, Weverton P. WAGNER Weverton Pereira Wagner Nunes W.P. AU - Colwell, Filipe AU - Semedo, J.N. José N. AU - Pais, I.P. Isabel P. AU - Batista-santos, Paula AU - Leitão, António E. A.E. Eduardo AU - Partelli, Fábio Luiz F.L. L. Fábio L. AU - Campostrini, Eliemar AU - Scotti-Campos, Paula AU - Ribeiro-Barros, A.I. Ana I. AU - Lidon, Fernando J. C. F.C. Fernando C. AU - DaMatta, F.M. Fabio Fábio Murilo Fabio M Fábio Murilo Fabio M. AU - Marias, Danielle E. AU - Meinzer, Frederick C. AU - Still, Christopher AU - Plantarum, Biologia AU - Covre, André Monzoli AU - Partelli, Fábio Luiz F.L. L. Fábio L. AU - Bonomo, Robson AU - Gontijo, Ivoney AU - Morris, Phil AU - Robbins, Mark AU - Mathur, S. AU - Jain, L. AU - Jajoo, A. AU - van Boxtel, Jos AU - Berthouly, Marc AU - Carasco, Cathy AU - Dufour, Magali AU - Eskes, Albertus AU - Gomes, Rui A. AU - Gratão, Priscila L. AU - Gaziola, Salete A. AU - Mazzafera, Paulo AU - Lea, Peter J. AU - Azevedo, Ricardo A. AU - Venzhik, Y. V. AU - Titov, A. F. AU - Talanova, V. V. AU - Miroslavov, E. A. AU - Koteeva, N. K. AU - Pardee, Gabriella L. AU - Philpott, Stacy M. AU - Martins, LIMA Deleon AU - Eugenio, FERNANDO Coelho AU - Rodrigues, Weverton P. WAGNER Weverton Pereira Wagner Nunes W.P. AU - Brinati, Sebastião Vinicius Batista AU - Colodetti, Tafarel Victor AU - Christo, Bruno Fardim AU - Olivas, Dionicio Belisario Luis AU - Partelli, Fábio Luiz F.L. L. Fábio L. AU - Amaral, José Francisco Teixeira do AU - Tomaz, Marcelo Antonio Antônio AU - Ramalho, José Cochicho Jose C J.C. José C. Domingos Cochicho AU - SANTOS, Alexandre Rosa dos AU - Warlop, F AU - Di Girolamo, Filippo Giorgio AU - Mazzucco, Sara AU - Situlin, Roberta AU - Mohorko, Nina AU - Jenko-Pražnikar, Zala AU - Petelin, Ana AU - Tence, Marcello AU - Pišot, Rado AU - Navarini, Luciano AU - Biolo, Gianni AU - Field, C. AU - Mooney, H. A. AU - Lima, Deleon Martins AU - Wagner, Nunes Rodrigues AU - Lindomar, Souza Machado AU - Sebastiao, Vinicius Batista Brinate AU - Tafarel, Victor Colodetti AU - Daniel, Soares Ferreira AU - Adan, Dezan Cogo AU - Marcio, Antonio Apostolico AU - Paulo, Eduardo Teodoro AU - Marcelo, Antonio Tomaz AU - Jose, Francisco Teixeira do Amaral AU - Fabio, Luiz Partelli AU - Jose, Cochicho Ramalho AU - Pongvinyoo, Pongthong AU - Yamao, Masahiro AU - Hosono, Kenji AU - Sridevi, V. AU - Giridhar, Parvatam AU - Meireles da Silva, Dayane AU - Brandão, Isabel Rodrigues AU - Alves, Jose Donizeti José Donizeti AU - de Santos, Meline Oliveira AU - de Souza, Kamila Rezende Dázio AU - de Silveira, Helbert Rezende Oliveira AU - J.C., Fernandez AU - S., Henriques F. AU - Jeremy, Haggar AU - Kathleen, Schepp AU - Kumar, By D AU - Agroecosystems, Shade Coffee AU - Jha, Shalene AU - Bacon, Christopher M. AU - Philpott, Stacy M. AU - Rice, Robert A. AU - Mendez, V Ernesto AU - Laderach, Peter AU - Weidner, Oliver AU - Muschler, Reinhold G AU - Morais, Leandro E. AU - Cavatte, Paulo C. AU - MEDINA, E. F. AU - SILVA, Paulo E. M. AU - Martins, Samuel C.V. Cordeiro Vitor AU - VOLPI, P. S. AU - JÚNIOR, S. ANDRADE AU - MACHADO FILHO, José Altino AU - Ronchi, Cláudio Pagotto AU - DaMatta, F.M. Fabio Fábio Murilo Fabio M Fábio Murilo Fabio M. AU - Ramalho, José Cochicho Jose C J.C. José C. Domingos Cochicho AU - Campos, Paula Scotti AU - Teixeira, Miguel AU - Nunes, Maria Antonieta AU - Perspectives, Genetic AU - Longo, Valentina AU - Janmohammadi, Mohsen AU - Zolla, Lello AU - Rinalducci, Sara AU - Jauregui, Iván AU - Rothwell, Shane A. AU - Taylor, Samuel H. AU - Parry, Martin A.J. J. AU - Carmo-Silva, Elizabete AU - Dodd, Ian C. AU - Brinate, Sebastião Vinícius Batista AU - Martins, LIMA Deleon AU - Pereira Rosa, Gustavo Nogueira Guedes AU - Cunha, Vinícius Vieira AU - de Jesus Sotero, Anderson AU - do Amaral, José Francisco Teixeira AU - de Jesus Junior, Waldir Cintra AU - Tomaz, Marcelo Antonio Antônio AU - Lahive, Fiona AU - Hadley, Paul AU - Daymond, Andrew J. AU - DaMatta, F.M. Fabio Fábio Murilo Fabio M Fábio Murilo Fabio M. AU - Godoy, Alice G. AU - Menezes-Silva, Paulo E. AU - Martins, Samuel C.V. Cordeiro Vitor AU - Sanglard, Lilian M.V.P. Lílian M.V.P. AU - Morais, Leandro E. AU - Torre-Neto, André AU - Ghini, Raquel AU - Sarmento, M. Joao AU - Ehrenbergerová, Lenka AU - Šenfeldr, Martin AU - Habrová, Hana AU - Deuner, Sidnei AU - Alves, Jose Donizeti José Donizeti AU - Zanandrea, Ilisandra AU - Goulart, Patrícia de Fátima Pereira AU - Silveira, Neidiquele Maria AU - Henrique, Paôla de Castro AU - Mesquita, Alessandro Carlos AU - Type, Item AU - Nadhim, Abdul-wahab AU - Martins, LIMA Deleon AU - Eugenio, FERNANDO Coelho AU - Rodrigues, Weverton P. WAGNER Weverton Pereira Wagner Nunes W.P. AU - JUNIOR, WALDIR AU - Tomaz, Marcelo Antonio Antônio AU - Ramalho, José Cochicho Jose C J.C. José C. Domingos Cochicho AU - SANTOS, Alexandre Rosa dos AU - Martins, Madlles Q. M.Q. Q AU - Fortunato, Ana S. A.S. Ana S. AU - Martins, LIMA Deleon AU - Pais, I.P. Isabel P. AU - Neuenschwander, Beat AU - Rodríguez-lópez, Nelson F AU - Martins, Samuel C.V. Cordeiro Vitor AU - Cavatte, Paulo C. AU - SILVA, Paulo E. M. AU - Morais, Leandro E. AU - Pereira, Luanna Fernandes Lucas Felisberto Luiz Filipe Protasio AU - REIS, Josimar Vieira dos AU - Ávila, Rodrigo T. AU - Godoy, Alice G. AU - Lavinski, Alyne O AU - DaMatta, F.M. Fabio Fábio Murilo Fabio M Fábio Murilo Fabio M. AU - Carelli, Maria Luiza Carva Iho L.C. AU - Queiroz-Voltan, Rachel Benetti AU - Fahl, Joel Irineu AU - Trivelin, Paulo César Ocheuze AU - Arsyad, Lincolin AU - Sodiq, Amirus AU - Covre, André Monzoli AU - Partelli, Fábio Luiz F.L. L. Fábio L. AU - Bonomo, Robson AU - Tomaz, Marcelo Antonio Antônio AU - Ramalho, José Cochicho Jose C J.C. José C. Domingos Cochicho AU - DaMatta, F.M. Fabio Fábio Murilo Fabio M Fábio Murilo Fabio M. AU - Rodrigues, Ana P. A.P. P. AU - Scotti-Campos, Paula AU - Pais, I.P. Isabel P. AU - Batista-santos, Paula AU - Partelli, Fábio Luiz F.L. L. Fábio L. AU - Ribeiro, Ana I André I Felipe Fialho Ana I. AU - Lidon, Fernando J. C. F.C. Fernando C. AU - Leitão, António E. A.E. Eduardo AU - De Smedt, Caroline AU - Steppe, Kathy AU - Spanoghe, Pieter AU - Lin, Brenda B. AU - Perfecto, Ivette AU - Vandermeer, John AU - Manufacture, Methods O F AU - King’oro, M. AU - Campany, Courtney E. AU - Medlyn, Belinda E. AU - Duursma, Remko A. AU - Bothe, Hermann AU - Happe, Thomas AU - Trebst, Simon AU - Rögner, Matthias AU - Intensity, Land-use AU - Agroforestry, Tropical AU - Cai, Z. Q. AU - Chen, Y. J. AU - Guo, Yu Hua AU - Cao, Kun Fang AU - Fortunato, Ana S. A.S. Ana S. AU - Lidon, Fernando J. C. F.C. Fernando C. AU - Batista-santos, Paula AU - Eduardo Leitão, António AU - Pais, I.P. Isabel P. AU - Ribeiro, Ana I André I Felipe Fialho Ana I. AU - Cochicho Ramalho, José D. AU - Bruns, Roy E AU - Scarminio, Ieda S AU - Shimizu, Milton Massao AU - Magalha, Jullyana Cristina AU - Pereira, Adilson AU - Ju, Domingues AU - Ramos, Augusto AU - Moura, Silva AU - Catharino, Rodrigo Ramos AU - Ribeiro, Rafael Vasconcelos AU - Mazzafera, Paulo AU - م.سلامة AU - Hiratsuka, Shin AU - Suzuki, Mayu AU - Nishimura, Hiroshi AU - Nada, Kazuyoshi AU - Gagliardi, Stephanie AU - Silva, Emerson A. AU - DaMatta, F.M. Fabio Fábio Murilo Fabio M Fábio Murilo Fabio M. AU - Ducatti, Carlos AU - Regazzi, Adair J. AU - Barros, Raimundo S. AU - Prado, Sara Guiti AU - Collazo, Jaime A. AU - Stevenson, Philip C. AU - Irwin, Rebecca E. AU - Silva, Maria L.O. G. J. AU - Pozza, E. A. AU - Vasco, G. B. AU - Freitas, A. S. AU - Chaves, E. AU - Paula, P. V.A.A. AU - Dornelas, G. A. AU - Alves, M. C. AU - Silva, Maria L.O. G. J. AU - Pozza, A. A.A. AU - Martini, Endri AU - Roshetko, James M AU - Scotti-Campos, Paula AU - Pais, I.P. Isabel P. AU - Partelli, Fábio Luiz F.L. L. Fábio L. AU - Batista-santos, Paula AU - Ramalho, José Cochicho Jose C J.C. José C. Domingos Cochicho AU - Cruz, Rebeca AU - Baptista, Paula AU - Cunha, Sara AU - Pereira, José S. Alberto AU - Casal, Susana AU - Batista, Karine D. AU - Araújo, Wagner L. AU - Antunes, Werner Camargos AU - Cavatte, Paulo C. AU - Moraes, Gustavo A.B.K. AU - Martins, Samuel C.V. Cordeiro Vitor AU - DaMatta, F.M. Fabio Fábio Murilo Fabio M Fábio Murilo Fabio M. AU - Yasuda, Takeshi AU - Fujii, Yoko AU - Yamaguchi, Tadashi AU - Barbosa, Ronei Aparecido AU - Santini, Paula Tristão AU - Guilherme, Luiz Roberto Guimarães AU - Uction, Introd AU - Simkin, Andrew J. AU - Moreau, Helene AU - Kuntz, Marcel AU - Lin, Chenwei AU - Tanksley, Steve AU - McCarthy, James AU - Rica, Costa AU - Li, Chunyang AU - Zheng, Y. AU - Zhou, J. AU - Xu, J. AU - Ni, D. AU - Georgieva, K. AU - Lichtenthaler, H. K. 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AU - Ribeiro-Barros, A.I. Ana I. AU - Eichler, P AU - Ramalho, José Cochicho Jose C J.C. José C. Domingos Cochicho AU - Partelli, Fábio Luiz F.L. L. Fábio L. AU - Fortunato, Ana S. A.S. Ana S. AU - Frischknecht, P M AU - Eller, B M AU - Baumann, Thomas W AU - Tounekti, T. AU - Mahdhi, M. AU - Al-Turki, T. A. AU - Khemira, H. AU - Perea Rojas, Yamel del Carmen AU - Arias, Rosa María AU - Medel Ortiz, Rosario AU - Trejo Aguilar, Dora AU - Heredia, Gabriela AU - Rodríguez Yon, Yakelin AU - Bote, Adugna Debela AU - Jan, Vos AU - Series, New AU - Barradas, Victor L AU - Permana, Agus Dana AU - Ramadhani Eka Putra, Jessica Esther N. AU - Pinheiro, Hugo A. AU - DaMatta, F.M. Fabio Fábio Murilo Fabio M Fábio Murilo Fabio M. AU - Chaves, Agnaldo R.M. M AU - Fontes, Elizabeth P.B. AU - Loureiro, Marcelo Ehlers AU - Araújo, André Vasconcellos AU - Partelli, Fábio Luiz F.L. L. Fábio L. AU - Oliosi, Gleison AU - Macedo Pezzopane, José Ricardo AU - Guo, Yu Hua AU - Yuan, C. AU - Tang, L. 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AU - Imbuzeiro, Hewlley M.A. AU - Fernandes, Raphael B.A. AU - Young, Andrew John AU - Saito, Moeko AU - Defrenet, Elsa AU - Roupsard, Olivier AU - Van den Meersche, Karel AU - Charbonnier, Fabien AU - Pérez-Molina, Junior Pastor AU - Khac, Emmanuelle AU - Prieto, Iván AU - Stokes, Alexia AU - Roumet, Catherine AU - Rapidel, Bruno AU - De Melo Virginio Filho, Elias AU - Vargas, Victor J. AU - Robelo, Diego AU - Barquero, Alejandra AU - Jourdan, Christophe AU - Lin, Brenda B. AU - Ramalho, José Cochicho Jose C J.C. José C. Domingos Cochicho AU - Marques, N C AU - Semedo, J.N. José N. AU - Matos, M C AU - Quartin, Virgínia L. AU - Etienne, Hervé AU - Black, Clanton C. AU - Cai, C. T. AU - Cai, Z. Q. AU - Yao, T. Q. AU - Qi, X. AU - Siles, Pablo AU - Harmand, Jean-michel AU - Vaast, Philippe AU - Mohammedsani, Amin Ameyu AU - Oestreich-Janzen, S. AU - De Almeida, Jenny AU - Herrera, Ana AU - Tezara, Wilmer AU - Rodrigues, Weverton P. WAGNER Weverton Pereira Wagner Nunes W.P. 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AU - Rodrigues, Gustavo Costa AU - Marraccini, Pierre AU - Andrade, André Baldansi Alan Carvalho AU - Menzel, Christopher M AU - Das, Biswadeep AU - Ghosal, Sayam AU - Mohanty, Swabhiman AU - Leroy, Thierry AU - Ribeyre, Fabienne AU - Bertrand, Benoit Benóit AU - Charmetant, Pierre AU - Dufour, Magali AU - Montagnon, Christophe AU - Marraccini, Pierre AU - Pot, David AU - Genetica, De AU - Paulo, S AU - Landbouwcatalogus, Centrale AU - Ngabitsinze, Jean Chrysostome AU - Mukashema, Adrie AU - Ikirezi, Mireille AU - Niyitanga, Fidèle AU - Nunes, Maria Antonieta AU - Contreiras, José AU - Silva, Dayane Meireles da Dulce Ferreira Da AU - Marias, Danielle E. AU - Meinzer, Frederick C. AU - Still, Christopher AU - Li, Zhao jun Zhi Xin AU - Yang, Wei Jun AU - Ahammed, Golam Jalal AU - Shen, Chen AU - Yan, Peng AU - Li, Xin AU - Han, Wen Yan AU - Kurata, Hiroyuki AU - Achioku, Tomohisa AU - Furusaki, Shintaro AU - Avelino, Jacques AU - Barboza, Bernardo AU - Davrieux, Fabrice AU - Guyot, Bernard AU - DaMatta, F.M. Fabio Fábio Murilo Fabio M Fábio Murilo Fabio M. AU - Rahn, Eric AU - LÄderach, Peter AU - Ghini, Raquel AU - Ramalho, José Cochicho Jose C J.C. José C. Domingos Cochicho AU - Worku, Mohammed AU - de Meulenaer, Bruno AU - Duchateau, Luc AU - Boeckx, Pascal AU - Classification, Publication AU - Baunthiyal, Mamta AU - Ranghar, Shweta AU - P., Vaast AU - J., Angrand AU - N., Franck AU - J., Dauzat AU - M., Génard AU - Maire, Vincent AU - Martre, Pierre AU - Kattge, Jens AU - Gastal, François AU - Esser, Gerd AU - Fontaine, Sébastien AU - Soussana, Jean François AU - CR, Warren AU - MA, Adams AU - Long, Nguyen Van AU - Ngoc, Nguyen Quang AU - Dung, Nguyen Ngoc AU - Kristiansen, Paul AU - Yunusa, Isa AU - Fyfe, Chris AU - Perret, S AU - Roudier, P AU - Rapidel, Bruno AU - Oosterveld, A AU - Voragen, A G J AU - Schols, H A AU - Dias, Kaio Gonçalves de Lima AU - Guimarães, Paulo Tácito Gontijo AU - Neto, Ana Paula Antônio Eduardo Furtini AU - Silveira, Helbert Rezende Oliveira de Oliveira AU - Lacerda, Julian Junio de Jesus Jordana Reis AU - Baumann, Thomas W AU - Gabriel, Helene AU - Oliveira, Jurandi Gonçalves de AU - Aguiar Alves, Pedro Luís da Costa AU - Vitória, Angela Pierre AU - DaMatta, F.M. 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F.C. Fernando C. AU - DaMatta, F.M. Fabio Fábio Murilo Fabio M Fábio Murilo Fabio M. AU - Ramalho, José Cochicho Jose C J.C. José C. Domingos Cochicho AU - Wang, San Lang AU - Nguyen, Anh Dzung AU - Bierhuizen, J F AU - Ryang, Hung-son AU - Cited, References AU - Schofer, Primary Examiner-joseph L AU - Smith, Assistant Examiner-jeffrey T AU - Marur, Celso Jamil AU - Faria, Rogério Teixeira AU - Simkin, Andrew J. AU - Kuntz, Marcel AU - Moreau, Helene AU - McCarthy, James AU - Sc, S M Gilbert B AU - Wye, Dip Agric AU - Lidon, Fernando J. C. F.C. Fernando C. AU - Fortunato, Ana S. A.S. Ana S. AU - Pais, I.P. Isabel P. AU - Ribeiro, Ana I André I Felipe Fialho Ana I. AU - Ramalho, José Cochicho Jose C J.C. José C. Domingos Cochicho AU - Ecofisiologia, Centro De AU - Da Matta, Fábio M. AU - Maestri, Moacyr AU - Mosquim, Paulo R. AU - Barros, Raimundo S. AU - Charbonnier, Fabien AU - Dreyer, Erwin AU - Casanoves, Fernando AU - Christina, Mathias AU - Dauzat, Jean AU - Eitel, Jan U H AU - Vaast, Philippe AU - Vierling, Lee A AU - Roupsard, Olivier AU - Rakocevic, Miroslava AU - Scholz Dos Santos, Maria Brigida AU - Good Kitzberger, Cintia Sorane AU - Ramalho, José Cochicho Jose C J.C. José C. Domingos Cochicho AU - Quartin, Virgínia L. AU - Leitão, E. AU - Campos, Paula Scotti AU - Carelli, Maria Luiza Carva Iho L.C. AU - Fahl, Joel Irineu AU - Nunes, Maria Antonieta AU - Fortunato, Ana S. A.S. Ana S. AU - Goulao, Luis F. AU - Lidon, Fernando J. C. F.C. Fernando C. AU - Mazzafera, Paulo AU - Manochai, Benya AU - Chulaka, Pariyanuj AU - Pichakum, Nath AU - Changlek, Prapart AU - Ovalle-Rivera, Oriana AU - LÄderach, Peter AU - Bunn, Christian AU - Obersteiner, Michael AU - Schroth, Götz AU - Forster, Britta AU - Bunn, Christian AU - LÄderach, Peter AU - Ovalle Rivera, Oriana AU - Kirschke, Dieter AU - Bote, Adugna Debela AU - Zana, Zewdneh AU - Ocho, Fikre L. AU - Vos, Jan AU - Partelli, Fábio Luiz F.L. L. Fábio L. AU - Batista-santos, Paula AU - Scotti-Campos, Paula AU - Pais, I.P. Isabel P. AU - Quartin, Virgínia L. AU - Vieira, Henrique D. AU - Ramalho, José Cochicho Jose C J.C. José C. Domingos Cochicho AU - Rodríguez, Daniel AU - Cure, José Ricardo AU - Cotes, José Miguel AU - Gutierrez, Andrew Paul AU - Cantor, Fernando AU - Salazar, Juan Carlos Suárez AU - Melgarejo, Luz Marina AU - Casanoves, Fernando AU - Di Rienzo, Julio A. AU - DaMatta, F.M. Fabio Fábio Murilo Fabio M Fábio Murilo Fabio M. AU - Armas, Cristina AU - Bauer, H AU - Larcher, W AU - Barros, Raimundo S. AU - Jay, Jay Wallace AU - Da Matta, Fábio M. AU - Maestri, Moacyr AU - Matos, Fábio S. AU - Wolfgramm, Ricardo AU - Gonçalves, Fábio V. AU - Cavatte, Paulo C. AU - Ventrella, Marília C. AU - DaMatta, F.M. Fabio Fábio Murilo Fabio M Fábio Murilo Fabio M. AU - Sciences, Agricultural AU - Rica, Costa AU - Speer, Karl AU - Kölling-Speer, Isabelle AU - Mofatto, Luciana Souto AU - Carneiro, Fernanda de Araújo AU - Vieira, Natalia Gomes AU - Duarte, Karoline Estefani AU - Vidal, Ramon Oliveira AU - Alekcevetch, Jean Carlos AU - Cotta, Michelle Guitton AU - Verdeil, Jean Luc AU - Lapeyre-Montes, Fabienne AU - Lartaud, Marc AU - Leroy, Thierry AU - De Bellis, Fabien AU - Pot, David AU - Rodrigues, Gustavo Costa AU - Carazzolle, Marcelo Falsarella AU - Pereira, Gonçalo Amarante Guimarães AU - Andrade, André Baldansi Alan Carvalho AU - Marraccini, Pierre AU - Lawson, T. AU - Blatt, M. R. AU - Ronchi, Cláudio Pagotto AU - De Almeida, Wellington Luiz AU - Souza, Daniela Silva AU - De Sousa, José Márcio AU - De Moura Guerra, Antonia Mirian Nogueira AU - Pimenta, Paulo Henrique Chaves AU - Jones, Matthew A. AU - Jassogne, Laurence AU - LÄderach, Peter AU - Asten, Piet V a N AU - Redgwell, Robert AU - Fischer, Monica AU - Da Rosa, S. D.V.F. AU - Veiga, A. D. AU - De Vilela, F. L. AU - Ferreira, I. A. AU - McDonald, M. B. AU - Plants, Coffee AU - Light, Bright AU - Martins, Madlles Q. M.Q. Q AU - Rodrigues, Weverton P. WAGNER Weverton Pereira Wagner Nunes W.P. AU - Fortunato, Ana S. A.S. Ana S. AU - Leitão, António E. A.E. Eduardo AU - Rodrigues, Ana P. A.P. P. AU - Pais, I.P. Isabel P. AU - Martins, LIMA Deleon AU - Silva, Maria L.O. G. J. AU - Reboredo, Fernando H. AU - Partelli, Fábio Luiz F.L. L. Fábio L. AU - Campostrini, Eliemar AU - Tomaz, Marcelo Antonio Antônio AU - Scotti-Campos, Paula AU - Ribeiro-Barros, A.I. Ana I. AU - Lidon, Fernando J. C. F.C. Fernando C. AU - DaMatta, F.M. Fabio Fábio Murilo Fabio M Fábio Murilo Fabio M. AU - Ramalho, José Cochicho Jose C J.C. José C. Domingos Cochicho AU - Biruk, Ayalew AU - Bayala, Jules AU - Noordwijk, Meine Van AU - Lusiana, Betha AU - Khasanah, Ni AU - Pompelli, Marcelo Francisco AU - Barata-Luís, Ricardo AU - Vitorino, Hermerson S. AU - Gonçalves, Eduardo R. AU - Rolim, Eduardo V. AU - Santos, Meline Oliveira Mauro G. AU - Almeida-Cortez, Jarcilene S. AU - Ferreira, Vilma M. AU - Lemos, Eurico E. AU - Endres, Laurício AU - Palupi, Dewi Nurma AU - Nguyen, T P D AU - Tran, T T H AU - Nguyen, Quynh Thi AU - Nguyen AU - Ghini, Raquel AU - Torre-Neto, André AU - Dentzien, Anamaria F.M. AU - Guerreiro-Filho, Oliveiro AU - Iost, Regiane AU - Patrício, Flávia R.A. AU - Prado, Jeanne S.M. AU - Thomaziello, Roberto A. AU - Bettiol, Wagner AU - DaMatta, F.M. Fabio Fábio Murilo Fabio M Fábio Murilo Fabio M. AU - Cao, Kun Fang AU - Guo, Yu Hua AU - Cai, Z. Q. AU - Pinheiro, Hugo A. AU - Totola, Marcos R. AU - Loureiro, Marcelo Ehlers AU - Lima, Ana Lúcia S. André Almeida AU - DaMatta, F.M. Fabio Fábio Murilo Fabio M Fábio Murilo Fabio M. AU - Pinheiro, Hugo A. AU - Totola, Marcos R. AU - Loureiro, Marcelo Ehlers AU - Ramalho, José Cochicho Jose C J.C. José C. Domingos Cochicho AU - Pons, Thijs L AU - Groeneveld, Henri W AU - Nunes, Maria Antonieta AU - Winston, Edward AU - Laak, Jacques Op De AU - Marsh, Tony AU - Lempke, Herbert AU - Chapman, Keith AU - Winston, Lao-pdr Edward AU - Laak, Jacques Op De AU - Marsh, Tony AU - Lempke, Herbert AU - Chapman, Keith AU - Geometry, Riemannian AU - Analysis, Geometric AU - Nguyen, Quynh Thi AU - Kozai, Toyoki AU - Niu, Genhua AU - Van Nguyen, Uyen AU - Kurata, Hiroyuki AU - Furusaki, Shintaro AU - QUICK, W. P. AU - CHAVES, M. M. AU - WENDLER, R. AU - DAVID, M. AU - RODRIGUES, M. L. AU - PASSAHARINHO, J. A. AU - Pereira, José S. Alberto AU - ADCOCK, M. D. AU - LEEGOOD, R. C. AU - Stitt, Mark AU - Flenker, Ulrich AU - Schänzer, Wilhelm AU - Walker, Berkley J. AU - Drewry, Darren T. AU - Slattery, Rebecca A. AU - VanLoocke, Andy AU - Cho, Young B. AU - Ort, Donald R. AU - Antunes, Werner Camargos AU - Pompelli, Marcelo Francisco AU - Carretero, D M AU - DaMatta, F.M. Fabio Fábio Murilo Fabio M Fábio Murilo Fabio M. AU - Avelino, Jacques AU - Zelaya, H. AU - Merlo, A. AU - Pineda, A. AU - Ordoñez, M. AU - Savary, Serge AU - Pompelli, Marcelo Francisco AU - Martins, Samuel C.V. Cordeiro Vitor AU - Antunes, Werner Camargos AU - Chaves, Agnaldo R.M. M AU - DaMatta, F.M. Fabio Fábio Murilo Fabio M Fábio Murilo Fabio M. AU - Grandis, Adriana AU - Arenque, Bruna C. AU - Buckeridge, Marcos S. AU - Netto, Alena Torres AU - Campostrini, Eliemar AU - De Oliveira, Jurandi Gonçalves AU - Bressan-Smith, Ricardo Enrique AU - Badea, C AU - Basu, S K AU - Tallman, Gary AU - Loyola-vargas, Victor M AU - Santos, G. C. AU - von Pinho, E. V.R. AU - Rosa, S. D.V.F. AU - Deligiannis, A. AU - Papazafeiropoulou, A. AU - Anastopoulos, G. AU - Zannikos, F. AU - da Silva, Paulo Silas Oliveira AU - Oliveira, Luiz Fernando Ganassali AU - Silva Gonzaga, Maria Isidória AU - de Oliveira Alves Sena, Edinaldo AU - dos Santos Maciel, Laila Beatriz AU - Pinheiro Fiaes, Matheus AU - de Mattos, Eloy Costa AU - Gutierrez Carnelossi, Marcelo Augusto AU - Pompelli, Marcelo Francisco AU - Cabrini, Elaine Cristina AU - Claudjane, Maria AU - Leite, Jerônimo AU - Alexsandro, Lara Teixeira AU - Flavio, de França Souza AU - Rodrigo, Barros Rocha AU - Jose, Roberto Vieira Junior AU - Josemar, Dávila Torres AU - Karine, Marques Rodrigues AU - Marcos, Santana de Moraes AU - Camila, Andrade Silva AU - Victor, Emanuel Goncalves de Oliveira AU - Joao, Luiz Resende Lourenco AU - Morais, Heverly AU - Medri, Moacyr Eurípedes AU - Marur, Celso Jamil AU - Caramori, Paulo Henrique AU - De Arruda Ribeiro, Ana Maria AU - Gomes, José Carlos AU - Peloso, Anelisa de Figueiredo AU - dos Reis, Edvaldo Fialho AU - Pezzopane, José Eduardo Macedo AU - do Amaral, José Francisco Teixeira AU - Tatagiba, Sandro Dan AU - Hirakawa, Takeshi AU - Kuwata, Keiko AU - Gallego, Maria Eugenia AU - White, Charles I. AU - Nomoto, Mika AU - Tada, Yasuomi AU - Matsunaga, Sachihiro AU - Bozzi, A. AU - Yuranova, T. AU - Guasaquillo, I. AU - Laub, D. AU - Kiwi, John AU - Lam, Luke K.T. AU - Sparnins, Velta L. AU - Wattenberg, Lee W. AU - Menezes-Silva, Paulo E. AU - Sanglard, Lilian M.V.P. Lílian M.V.P. AU - Ávila, Rodrigo T. AU - Morais, Leandro E. AU - Martins, Samuel C.V. Cordeiro Vitor AU - Nobres, Priscilla AU - Patreze, Camila M. AU - Ferreira, Marcio A. AU - Araújo, Wagner L. AU - Fernie, Alisdair R. AU - DaMatta, F.M. Fabio Fábio Murilo Fabio M Fábio Murilo Fabio M. AU - Saha, Supradip AU - Mandal, Abhishek AU - Dutta, Anirban AU - Assis, Bruno dos Passos AU - Gross, Eduardo AU - Pereira, Norma Eliane AU - Mielke, Marcelo Schramm AU - Júnior, Gedeon Almeida Gomes AU - Paper, Conference AU - Pinheiro, Hugo A. AU - DaMatta, F.M. Fabio Fábio Murilo Fabio M Fábio Murilo Fabio M. AU - Chaves, Agnaldo R.M. M AU - Loureiro, Marcelo Ehlers AU - Ducatti, Carlos AU - Yoshinaga, Naganori AU - Kato, Yoshiro AU - Kato, Yoshiro AU - Nakai, Makoto AU - Jayakumar, M. AU - Rajavel, M. AU - Surendran, U. AU - Thi Nguyen, Quynh AU - Kozai, Toyoki AU - Heo, Jeongwook AU - Xuan Thai, Du AU - Somporn, Chanyarin AU - Theerakulpisut, Piyada AU - Wilkinson, Robert E. AU - Padovan, M. P. AU - Brook, R. M. AU - Barrios, Mirna AU - Cruz-Castillo, J. B. AU - Vilchez-Mendoza, S. J. AU - Costa, A. N. AU - Rapidel, Bruno AU - Meylan, Louise AU - Gary, Christian AU - Allinne, Clémentine AU - Ortiz, Jorge AU - Jackson, Louise AU - Rapidel, Bruno AU - Nijhoff, Martinus AU - Publishers, Junk AU - Way, Maile AU - Gomez, Céline AU - Despinoy, Marc AU - Hamon, Serge AU - Hamon, Perla AU - Salmon, Danyela AU - Akaffou, Doffou Sélastique AU - Legnate, Hyacinthe AU - de Kochko, Alexandre AU - Mangeas, Morgan AU - Poncet, Valérie AU - ZHANG, Cheng AU - FENG, Yao AU - LIU, Yuan wang AU - CHANG, Hui qing AU - Li, Zhao jun Zhi Xin AU - XUE, Jian ming AU - Iglesias, D J AU - Lliso, I AU - Tadeo, F R AU - Talon, M AU - Kurata, Hiroyuki AU - Matsumura, Satoru AU - Aluka, Pauline AU - Of, Jour A L AU - Campos, Ramalho Paula S AU - Nunes, Antonieta AU - Silva, Maria L.O. G. J. AU - Avelino, Jacques AU - Allinne, Clémentine AU - Cerda, Rolando AU - Willocquet, Laetitia AU - Savary, Serge AU - Centre, Biotechnology AU - Coffee, Central AU - Board, Coffee AU - Castellanos-onorio, O AU - Gonzalez-rios, O AU - Guyot, Bernard AU - Fontana, Tachon A AU - Guiraud, J P AU - Franck, Nicolás AU - Winkler, Sylvia AU - Pastenes, Claudio AU - Infante, Rodrigo AU - D'haeze, Dave AU - Deckers, Jozef AU - Raes, Dirk AU - Phong, Tran An AU - Chanh, Nguyen Dang Minh AU - Pinheiro, Hugo A. AU - Ribeiro, Æ Aristides AU - Duan, Baoli AU - Lu, Yanwei AU - Yin, Chunying AU - Junttila, Olavi AU - Li, Chunyang AU - Vignoli, J A AU - Bassoli, D G AU - Benassi, M T AU - Ho, Quang Tri AU - Verboven, Pieter AU - Yin, Xinyou AU - Struik, Paul C. AU - Nicolaï, Bart M. AU - Dias1, Kaio Gonçalves de Lima AU - , Paulo Tácito Gontijo Guimarães2, Antônio Eduardo Furtini Neto3 AU - Faquin4, Valdemar AU - , Eduane José de Pádua5, Helbert Rezende Oliveira de Silveira6 AU - Coa Urbaez, Martín AU - Silva-Acuña, Ramón AU - Méndez Natera, Jesús Rafael AU - Mundarain Padilla, Sol AU - Mosquera, Lyda Patricia AU - Riaño, Néstor M AU - López, Yamel AU - Arcila, Jaime AU - Kurata, Hiroyuki AU - Achioku, Tomohisa AU - Okuda, Naoyuki AU - Furusaki, Shintaro AU - Covre, André Monzoli AU - Partelli, Fábio Luiz F.L. L. Fábio L. AU - Bonomo, Robson AU - Braun, Heder AU - Ronchi, Cláudio Pagotto AU - DaMatta, F.M. Fabio Fábio Murilo Fabio M Fábio Murilo Fabio M. AU - Ronchi, Cláudio Pagotto AU - Maestri, Moacyr AU - Barros, Raimundo S. AU - Gao, Yixuan AU - Paridah, M.t AU - Moradbak, Amin AU - Mohamed, A.Z AU - Owolabi, Folahan abdulwahab taiwo AU - Asniza, Mustapha AU - Abdul Khalid, Shawkataly H.P AU - Santos, Meline Oliveira Mauro G. AU - de Oliveira Silveira, Helbert Rezende AU - de Souza, Kamila Rezende Dázio AU - Lima, Ana Lúcia S. André Almeida AU - Boas, Lissa Vasconcellos Vilas AU - Barbosa, Bárbara Castanheira Ferrara AU - Barreto, Horllys Gomes AU - Alves, Jose Donizeti José Donizeti AU - Chalfun-Junior, Antonio AU - DaMatta, F.M. Fabio Fábio Murilo Fabio M Fábio Murilo Fabio M. AU - Cochicho Ramalho, José D. AU - Moraes, Gustavo A.B.K. AU - Chaves, Agnaldo R.M. M AU - Martins, Samuel C.V. Cordeiro Vitor AU - Barros, Raimundo S. AU - DaMatta, F.M. Fabio Fábio Murilo Fabio M Fábio Murilo Fabio M. AU - Ramalho, José Cochicho Jose C J.C. José C. Domingos Cochicho AU - Pais, I.P. Isabel P. AU - Leitão, António E. A.E. Eduardo AU - Guerra, Mauro AU - Reboredo, Fernando H. AU - Máguas, Cristina M. AU - Carvalho, Maria L. AU - Scotti-Campos, Paula AU - Ribeiro-Barros, A.I. Ana I. AU - Lidon, Fernando J. C. F.C. Fernando C. AU - DaMatta, F.M. Fabio Fábio Murilo Fabio M Fábio Murilo Fabio M. AU - CARR, M. K. V. AU - Martins, Samuel C.V. Cordeiro Vitor AU - Galmés, Jeroni AU - Cavatte, Paulo C. AU - Pereira, Luanna Fernandes Lucas Felisberto Luiz Filipe Protasio AU - Ventrella, Marília C. AU - DaMatta, F.M. Fabio Fábio Murilo Fabio M Fábio Murilo Fabio M. AU - Rodrigues, Weverton P. WAGNER Weverton Pereira Wagner Nunes W.P. AU - Martins, Madlles Q. M.Q. Q AU - Fortunato, Ana S. A.S. Ana S. AU - Rodrigues, Ana P. A.P. P. AU - Semedo, J.N. José N. AU - Simões-Costa, Maria C. AU - Pais, I.P. Isabel P. AU - Leitão, António E. A.E. Eduardo AU - Colwell, Filipe AU - Goulao, Luis F. AU - Máguas, Cristina M. AU - Maia, Rodrigo AU - Partelli, Fábio Luiz F.L. L. Fábio L. AU - Campostrini, Eliemar AU - Scotti-Campos, Paula AU - Ribeiro-Barros, A.I. Ana I. AU - Lidon, Fernando J. C. F.C. Fernando C. AU - DaMatta, F.M. Fabio Fábio Murilo Fabio M Fábio Murilo Fabio M. AU - Ramalho, José Cochicho Jose C J.C. José C. Domingos Cochicho AU - Dubberstein, Danielly AU - Rodrigues, Weverton P. WAGNER Weverton Pereira Wagner Nunes W.P. AU - Semedo, J.N. José N. AU - Rodrigues, Ana P. A.P. P. AU - Pais, I.P. Isabel P. AU - Leitão, António E. A.E. Eduardo AU - Partelli, Fábio Luiz F.L. L. Fábio L. AU - Campostrini, Eliemar AU - Reboredo, Fernando H. AU - Scotti-Campos, Paula AU - Lidon, Fernando J. C. F.C. Fernando C. AU - Ribeiro-Barros, A.I. Ana I. AU - DaMatta, F.M. Fabio Fábio Murilo Fabio M Fábio Murilo Fabio M. AU - Ramalho, José Cochicho Jose C J.C. José C. Domingos Cochicho AU - Damatta, M AU - Franck, Nicolás AU - Vaast, Philippe AU - Ramalho, José Cochicho Jose C J.C. José C. Domingos Cochicho AU - Rodrigues, Ana P. A.P. P. AU - Semedo, J.N. José N. AU - Pais, I.P. Isabel P. AU - Martins, LIMA Deleon AU - Simões-Costa, Maria C. AU - Leitão, António E. A.E. Eduardo AU - Fortunato, Ana S. A.S. Ana S. AU - Batista-santos, Paula AU - Palos, Isabel M. AU - Tomaz, Marcelo Antonio Antônio AU - Scotti-Campos, Paula AU - Lidon, Fernando J. C. F.C. Fernando C. AU - DaMatta, F.M. Fabio Fábio Murilo Fabio M Fábio Murilo Fabio M. AU - Brunner, Sarah AU - Pereira, Luanna Fernandes Lucas Felisberto Luiz Filipe Protasio AU - Ivamoto, Suzana Tiemi AU - Grandgirard, Julie AU - Poinsot, Denis AU - Krespi, Liliane AU - Nénon, Jean Pierre AU - Cortesero, Anne Marie AU - Fortunato, Ana S. A.S. Ana S. AU - Batista-santos, Paula AU - Rodrigues, Weverton P. WAGNER Weverton Pereira Wagner Nunes W.P. AU - Silva, Jefferson R. AU - Ferreira, Luciene S. Lúcia Pires Luciene Souza AU - Filho, José Altino Machado AU - Figueiredo, Fabio A. M. M. A. Fábio A.M.M.A. AU - Ferraz, Tiago Massi AU - Bernado, Wallace P. AU - Bezerra, Luan B. S. AU - de Abreu, Deivisson Pelegrino AU - Cespom, Letícia AU - Ramalho, José Cochicho Jose C J.C. José C. Domingos Cochicho AU - Campostrini, Eliemar AU - Silva, Vânia Aparecida AU - Prado, Fernanda Manso AU - Antunes, Werner Camargos AU - Paiva, Rita Márcia Cardoso AU - Ferrão, Maria Amélia Gava AU - Andrade, André Baldansi Alan Carvalho AU - Di Mascio, Paolo AU - Loureiro, Marcelo Ehlers AU - DaMatta, F.M. Fabio Fábio Murilo Fabio M Fábio Murilo Fabio M. AU - Almeida, Andréa Miyasaka AU - Staver, C AU - Guharay, F AU - Monterroso, D AU - Muschler, Reinhold G AU - Nechushtai, Rachel AU - Elit, Motza AU - Systems, Sonora Medical AU - Way, Danielle A AU - Ribeiro, Ana I André I Felipe Fialho Ana I. AU - Matsumoto, Sylvana Naomi AU - Pereira, Luanna Fernandes Lucas Felisberto Luiz Filipe Protasio AU - De Oliveira, Ueliton Soares AU - Teixeira, Ednilson Carvalho AU - Ramos, Paula Acácia Silva AU - Somporn, Chanyarin AU - Kamtuo, Amnouy AU - Theerakulpisut, Piyada AU - Siriamornpun, Sirithon AU - Cavatte, Paulo C. AU - Oliveira, Álvaro A.G. AU - Morais, Leandro E. AU - Martins, Samuel C.V. Cordeiro Vitor AU - Sanglard, Lilian M.V.P. Lílian M.V.P. AU - DaMatta, F.M. Fabio Fábio Murilo Fabio M Fábio Murilo Fabio M. AU - Campa, Claudine AU - Urban, Laurent AU - Mondolot, Laurence AU - Fabre, Denis AU - Roques, Sandrine AU - Lizzi, Yves AU - Aarrouf, Jawad AU - Doulbeau, Sylvie AU - Breitler, Jean-Christophe AU - Letrez, Céline AU - Toniutti, Lucile AU - Bertrand, Benoit Benóit AU - La Fisca, Philippe AU - Bidel, Luc P. R. AU - Etienne, Hervé AU - Pessarakli, Mohammad AU - Jha, Shalene AU - Bacon, Christopher M. AU - Philpott, Stacy M. AU - MÉndez, V. Ernesto AU - LÄderach, Peter AU - Rice, Robert A. AU - Drake, Paul L. AU - de Boer, Hugo J. AU - Schymanski, Stanislaus J. AU - Veneklaas, Erik J. AU - Yanpisitkun, Nattawit AU - Chiarawipa, Rawee AU - Pechkeo, Surachart AU - Charbonnier, Fabien AU - Roupsard, Olivier AU - le Maire, Guerric AU - Guillemot, Joannès AU - Casanoves, Fernando AU - Lacointe, André AU - Vaast, Philippe AU - Allinne, Clémentine AU - Audebert, Louise AU - Cambou, Aurélie AU - Clément-Vidal, Anne AU - Defrenet, Elsa AU - Duursma, Remko A. AU - Jarri, Laura AU - Jourdan, Christophe AU - Khac, Emmanuelle AU - Leandro, Patricia AU - Medlyn, Belinda E. AU - Saint-André, Laurent AU - Thaler, Philippe AU - Van den Meersche, Karel AU - Barquero Aguilar, Alejandra AU - Lehner, Peter AU - Dreyer, Erwin AU - Geromel, Clara AU - Ferreira, Luciene S. Lúcia Pires Luciene Souza AU - Davrieux, Fabrice AU - Guyot, Bernard AU - Ribeyre, Fabienne AU - Brígida dos Santos Scholz, Maria AU - Protasio Pereira, Luiz Filipe AU - Vaast, Philippe AU - Pot, David AU - Leroy, Thierry AU - Filho, Armando Androcioli AU - Esteves Vieira, Luiz Gonzaga AU - Mazzafera, Paulo AU - Marraccini, Pierre AU - Siebert, S. F. AU - Guo, Yu Hua AU - Cao, Kun Fang AU - Bote, Adugna Debela AU - Struik, Paul C. AU - Shahidi, Fereidoon AU - Ambigaipalan, Priyatharini AU - Martin, Adam R. AU - Rapidel, Bruno AU - Roupsard, Olivier AU - Van den Meersche, Karel AU - De Melo Virginio Filho, Elias AU - Barrios, Mirna AU - Isaac, Marney E. AU - Cesarino, Igor AU - Mazzafera, Paulo AU - Coffee, Shade-grown Arabica AU - Nakayan, Phanit AU - Techanant, Pracha AU - Sungpalee, Witchaphart AU - Konsaeng, Sawika AU - Epstein, Marc J. AU - Yuthas, Kristi AU - Iii, William W Adams AU - Stewart, Jared J AU - Demmig-adams, Barbara AU - Neoh, Bee Keat AU - Teh, Huey Fang AU - Wong, YT Yick Ching AU - Eng, Tony AU - Ooi, Keong AU - Cheah, See Siang AU - Appleton, David R AU - Hameed, Ahsan AU - Hussain, Syed Ammar Shahzad AU - Ansar, Hafiz AU - Suleria, Rasul AU - Fajrin, Hanifah Rahmi AU - Zakiyyah, Ummu AU - Supriyadi, Kuat AU - Hamsar, Adriana AU - Ramadhan, Ety Sofia AU - T.M.F., Caneppele AU - C.R.G., Torres AU - M.F.R.L., Huhtala AU - E., Bresciani AU - Redaksi, Susunan Dewan AU - Munisse, Paulino AU - Andersen, Sven Bode AU - Jensen, Brita Dahl AU - Christiansen, Jørgen Lindskrog AU - Ariana, Taufiah Resa AU - Wibisono, Gunawan AU - Praptiningsih, Rahmawati Sri AU - Sitepu, Yovani Rehuel Br AU - Simanungkalit, Jesica Natalia AU - Iswari, Shabrina AU - Pujiastuti, Yunita Ali AU - Muhamadiyah, Stikes AU - Wijaya, Heri AU - Novitasari AU - Jubaidah, Siti IS - 1 KW - "Coffea arabica L. KW - "Robusta Coffee KW - - chlorophyll a fluorescence KW - - photosynthesis - purine KW - 1 KW - 10 KW - 12691 KW - 13-28 KW - 15 gedung grha ilon KW - 1970 KW - 2 KW - 2 compensation point á KW - 2 fixation á gibbs KW - 20 KW - 2014 KW - 2017 KW - 2020 KW - 22146 KW - 25 KW - 2560 KW - 284 KW - 296 KW - 3014 KW - 34-39 KW - 4 KW - 40 KW - 4268 KW - 45666 KW - 48 KW - 5-diphenyl-carbohydrazide KW - 5-hydroxytryptamides KW - 6-dichlorophenolindo- KW - 6-dichlorophenolindophenol KW - ABA KW - Acclimation KW - Acetic acid KW - Acidity KW - Acrocomia aculeate KW - Active oxygen species KW - Acúmulo de nutrientes KW - Adaptation KW - Adaptive management KW - Agrobacterium transformation KW - Agroforestry KW - Agroforestry system KW - Agroforestry systems KW - Agronomic efficiency KW - Air humidity KW - Allometry KW - Amax KW - Amazonia KW - Amino acids KW - Antibacterial activity KW - Antioxidant KW - Antioxidant activity KW - Antioxidant enzymes KW - Antioxidant system KW - Antioxidants KW - Apel KW - Apparent nitrogen recovery KW - Arabica KW - Arabica coffee KW - Aroma chemistry KW - Asam Malat KW - Ascorbate peroxidase KW - Asobara tabida KW - Aspegillus niger KW - Assimilate KW - Avoidance strategy KW - Bactericidal KW - Bean biochemical content KW - Bean composition KW - Beans KW - Bearing pattern KW - Berry KW - Berry maturation KW - Bienniality KW - Bio-fertilization KW - Bioactive components KW - Bioactive compounds KW - Bioactive molecules KW - Bioclimatic envelope KW - Biomass KW - Biomass allocation KW - Boron KW - Botany KW - Brazil KW - Bundle sheath cells KW - C KW - CBB KW - CO2 concentration KW - CO2 enriched condition KW - CO2 enrichment KW - CO2 saturation point KW - Cafestol KW - Caffeine KW - Café KW - Calamus zollingeri KW - Calcium carbonate KW - Calcium oxide KW - Camellia sinensis KW - Candidate gene KW - Carbohydrate KW - Carbohydrate partitioning KW - Carbohydrates KW - Carbon KW - Carbon allocation KW - Carbon isotope composition KW - Carbon isotope discrimination KW - Carbon isotope ratio KW - Carbon metabolism KW - Carotenoids KW - Cassia obtusifolia KW - Cellular damages KW - Chilling KW - Chilling stress KW - Chilling tolerance KW - Chitosan nanoparticles KW - Chlorogenic acid. KW - Chlorogenic acids KW - Chlorophyll KW - Chlorophyll a fluorescence KW - Chlorophyll a fluorescence transient O-J-I-P KW - Chlorophyll fluorescence KW - Chlorophyll fluorescence decrease ratio KW - Chlorophyll fluorescence kinetics KW - Chloroplast KW - Chloroplast lipid fatty acids KW - Chloroplast membranes KW - Chloroplast ultrastructure KW - Citrus sinensis KW - Citrus unshiu KW - Citrus variegated chlorosis KW - Climate KW - Climate Change KW - Climate change KW - Cluster analysis KW - Cocoa KW - Coffea KW - Coffea Arabica KW - Coffea arabi KW - Coffea arabica KW - Coffea arabica L KW - Coffea arabica L. KW - Coffea arabusta KW - Coffea canephora KW - Coffea canephora Pierre KW - Coffea sp. KW - Coffea species KW - Coffea spp KW - Coffee KW - Coffee agriculture KW - Coffee agroforestry KW - Coffee beverage quality KW - Coffee effluent KW - Coffee growth KW - Coffee leaf water potential KW - Coffee leaves KW - Coffee plant KW - Coffee producers KW - Coffee rust KW - Coffee stress KW - Coffee tree KW - Coffee yield KW - Cold KW - Cold adaptation KW - Cold resistance KW - Colored coffee effluent KW - Competition for water KW - Correspondence analysis KW - Costa Rica KW - Cotton textiles KW - Crop management KW - Crop transpiration KW - Crop yield KW - Cultivar differences KW - Cup quality KW - Daylight irradiation KW - Decolorization KW - Deficit hídrico KW - Delia radicum KW - Desiccation tolerance KW - Development KW - Differential acclimation KW - Differential gene expression KW - Diffusion limitations KW - Discoloration KW - Disease control KW - Diterpenes KW - Drip irrigation KW - Drosophila melanogaster KW - Drought KW - Drought memory KW - Drug and narcotic control KW - ESTs KW - Ecophysiology KW - Ecosystem services KW - Elastic and osmotic adjustments KW - Electrolyte leakage KW - Elevated CO2 KW - Elevated [CO 2 ] KW - Elevation KW - Enamel KW - Endo-β-mannanase KW - Environmental factors KW - Environmental stress KW - Erythrina poeppigiana KW - Eucalyptus KW - Evaporative demand KW - Evapotranspiration KW - Expansion KW - FACE KW - Facultative hyperparasitism KW - Fast fluorescence kinetics KW - Fat KW - Fatty acids KW - Fenton regent KW - Ferralsol KW - Fertilizer technologies KW - Fine Root Decomposition KW - Fitness KW - Fitrianda KW - Flavonoids KW - Flow rate KW - Flowering phenology KW - Fluorescence KW - Fluorescence of chlorophyll a KW - Fluoride accumulation KW - Fluoride toxicity KW - Foliage KW - Food quality KW - Forced ventilation KW - Frost KW - Fruit Stoma KW - Fruit development KW - Fruit load KW - Fruit photosynthesis KW - Fruit thinning KW - Functional foods KW - Fv/Fm KW - G KW - GC-MS KW - Garcae KW - Gas chromatography-mass spectrometry KW - Gas exchange KW - Gas exchange parameters KW - Gene expression KW - Genetic KW - Geostatistics KW - Global climatic changes KW - Global warming KW - Glutathione reductase KW - Growth KW - Growth Rings KW - Growth and development KW - Health benefits KW - Heat KW - Heat stress KW - Heat tolerance KW - Heavy metals KW - Helianthus KW - Hemileia vastatrix KW - Hevea brasiliens KW - Hevea brasiliensis KW - Hierarchical cluster analysis KW - High density planting KW - High irradiance KW - High temperature KW - High-density planting KW - History KW - Honduras KW - Hormones KW - Host quality KW - Host size KW - Hybrid zone KW - Hymenoptera KW - Inhibitors KW - Insect repellant KW - Insulin resistance KW - Interactions KW - Intercropping KW - Introduction KW - Irradiance KW - Irrigation KW - Isoenzyme KW - Isoprenoids KW - Isotopes KW - Jatropha curcas L. KW - Jiptest KW - Kahweol KW - Key transformation processes KW - Leaf age KW - Leaf anatomy KW - Leaf and air temperatures KW - Leaf area KW - Leaf carbon isotope composition KW - Leaf conductance KW - Leaf position KW - Leaf respiration rates KW - Leguminosae KW - Length KW - Lettuce KW - Light KW - Light Intensity KW - Light and dark phases KW - Light intensity KW - Light interception KW - Light quality KW - Light transmittance KW - Lincolin Arsyad KW - Lipid classes KW - Lipid peroxidation KW - Lipids KW - Low temperature KW - Low temperature plasma KW - Lupinus KW - Lutein KW - MAESPA KW - Macronutrients KW - Main components KW - Maize KW - Malonate metabolism KW - Malondialdehyde KW - Mass spectrometry KW - Medicine & Pharmacology KW - Meilina Indah KW - Metabolic acclimation KW - Metabolic pool KW - Metabolomics KW - Metal homeostasis KW - Microclimate KW - Microclimate management KW - Micronutrients KW - Mineral nutrition KW - Mineralization KW - Mineralogy KW - Mitigation strategy KW - Modeling KW - Moderate water availability KW - Monoammonium phosphate KW - Monoculture KW - Morphology KW - Mulching KW - N fixation KW - N uptake KW - NPP KW - Nanofertilizer KW - Natural antioxidants KW - Natural ventilation KW - Net photosynthesis KW - Net photosynthetic rate KW - New Caledonia KW - Niche KW - Nicotiana tabacum KW - Nitrogen KW - Nitrogen availability KW - Nitrogen concentration KW - Number of air exchanges KW - Nutrient accumulation KW - Nutrient solution KW - Nutrition KW - Nutrição mineral KW - Omega-3 fatty acids KW - Osmotic adjustment KW - Oxidative stress KW - Oxisols KW - PEMBELAJARAN KONVENSIONAL PADA MATA PELAJARAN EKON KW - PERBEDAAN HASIL BELAJAR MELALUI PENDEKATAN SAINTIF KW - PPF saturation point KW - Pachycrepoideus dubius KW - Paraquat KW - Partitioning KW - Pemutihan Gigi. KW - Penicillium brevicompactum KW - Pentose phosphate pathway KW - Peru KW - Perubahan Warna Gigi KW - Phenolic acid KW - Phenology KW - Phenols KW - Phenotypic Diversity KW - Phenotypic plasticity KW - Phosphatases KW - Phospholipids KW - Phosphorus KW - Photo-Fenton reaction KW - Photoautotrophic micropropagation KW - Photochemical efficiency KW - Photoinhibition KW - Photoprotection KW - Photosynthesis KW - Photosynthesis down-regulation KW - Photosynthetic acclimation KW - Photosynthetic efficiency KW - Photosynthetic electron transport KW - Photosynthetic limitations KW - Photosynthetic pigments KW - Photosynthetic. pigments KW - Photosystem II KW - Photosystem II quantum yield KW - Photosystems KW - Physiologic effects KW - Physiological efficiency KW - Physiology KW - Pigments KW - Pinhead KW - Pisum KW - Plant calorimetry KW - Plant functional types KW - Plant growth KW - Plant physiology KW - Plant–environment interactions KW - Polyphenols KW - Population dynamics KW - Portable chlorophyll meter KW - Pre-treatment KW - Precipitation KW - Principal component analysis KW - Productivity KW - Pseudomonas syringae pv KW - Pteromalidae KW - Purging nut KW - Quantum efficiency KW - RNA-Seq KW - RT-PCR KW - RT-qPCR KW - Radiation KW - Rainfall KW - Rainfed agriculture KW - Reactive oxygen species KW - Real-time PCR (RT-qPCR) KW - Redox signalling KW - Relative growth rate KW - Remobilization KW - Respiration KW - Respiratory enzymes KW - Ripening phase KW - Roasting intensity KW - Robusta Coffee KW - Robusta coffee KW - RuBisCO KW - RuBisCO oxygenation/carboxylation rates KW - Rubisco activity KW - Salicylic acid KW - Salinity KW - Scavenging molecules KW - Scavenging systems KW - Sclerophylls KW - Seed aging KW - Seed extract KW - Segmentation tree KW - Selenium KW - Self-cleaning KW - Senescence KW - Sensory analysis KW - Sequential Coring KW - Shade KW - Shade coffee systems KW - Shade leaves KW - Shaded Coffee KW - Shaded perennials KW - Shading KW - Signalling KW - Silver nanoparticles KW - Singlet oxygen KW - Sink feedback KW - Sink regulation KW - Soil KW - Soil amendment KW - Soil evaporation KW - Soil fertility KW - Soil fungi KW - Soil moisture fluctuation KW - Soil temperature KW - Soil volume KW - Soil water and thermal dynamics KW - Soil water availability KW - Solar energy KW - Solar light dose rate KW - Solar radiation KW - Soluble sugars KW - Sonneratia caseolaris KW - Source-sink manipulation KW - Source-sink relationships KW - Source/sink relationship KW - Southern Chile KW - Southwestern Ethiopia KW - Spent coffee grounds KW - Spodoptera litura KW - Sports KW - Starch KW - Statistical model KW - Stomatal conductance KW - Stomatal traits KW - Stress adaptation index KW - Structure/function relationships KW - Sucrose KW - Sucrose synthase KW - Sucrose-phosphate synthase KW - Sugar metabolism KW - Sugars KW - Sun leaves KW - Superoxide dismutase KW - Synergism KW - Synthetic antioxidants KW - Tea KW - Tea polyphenol KW - Temperature KW - Temperature coefficient KW - Thailand KW - Theobromine KW - Thermal dissipation KW - Thermo-sensitivity KW - Thermoinhibition KW - TiO2 colloids KW - TiO2 rutile clusters KW - Tissue culture KW - Tolerance KW - Topography KW - Tradeoff KW - Transpiration KW - Transpiration rate KW - Trigonelline KW - Triticum aestivum L. KW - Tropical agriculture KW - Trybliographa rapae KW - Type-2 diabetes mellitus KW - UV–vis spectroscopy KW - Uganda KW - Ugni molinae KW - Ultisols KW - Unsaturation KW - V-UV KW - VPD KW - Vapour pressure deficit KW - Variability KW - Vegetative growth KW - Vietnam KW - Vitamin E KW - Vitis KW - WAVE KW - Water availability KW - Water d KW - Water deficit KW - Water potential KW - Water relations KW - Water stress KW - Water use KW - Water use efficiency KW - Water-use efficiency KW - Whole plant KW - Width KW - Winter and Summer conditions KW - Xanthophyll cycle KW - Xanthophylls KW - Yield KW - Yield components KW - Zinc KW - a KW - a fração lipídica da KW - a fração lipídica do KW - a grande variabilidade na KW - abbreviations KW - abreviaturas KW - abstract KW - access and in certain KW - acetone KW - adaptation irradiance KW - adicionalmente KW - agricultural intensification KW - agricultural sci KW - agriculture KW - agro-based KW - agrobacterium transformation KW - agroecological resistance KW - agroecology KW - agroforestry KW - agroforestry systems KW - aha KW - air temperature KW - ajrd-2-2-3 KW - akan timbul pertanyaan apakah KW - alamat korespondensi KW - alkaloid KW - alkaloids KW - alkaloids and light - KW - amax KW - american journal of rural KW - amino acids KW - among coffee farmers in KW - amphistomatous KW - analis farmasi dan makanan KW - analisam-se aspectos do crescimento KW - analysis of variance KW - and kenji hosono KW - and light saturating conditions KW - and one sample t KW - and shade leaves KW - animal tissue KW - antibacterial KW - antibacterial activity test KW - antioxidant KW - antioxidant activity KW - antioxidant system KW - antioxidants KW - any distribution KW - ao crescimento vegetativo e KW - ap KW - apx_ascorbate peroxidase KW - aquadest KW - aquilaria malaccensis lamk KW - arabica KW - arabica coffee KW - arabinogalactans KW - arbuscular mycorrhizal fungi KW - area KW - article KW - artificial KW - artificial light KW - artocarpus heterophyllus lam l KW - asma genotiplerinde düşük gece KW - autophagyc type 2 diabetes KW - azteca instabilis KW - banda aceh KW - bean quality KW - beef KW - benzyladenine KW - berry drop KW - berry mass KW - berry pho- KW - beverage quality KW - biochemical compounds KW - biochemical limitation - etr KW - biodiesel KW - biodiversidad KW - biofuels KW - biological control KW - biomass allocation KW - bioremediation KW - biosensors KW - bl KW - body of information on KW - branch dieback KW - bromelain KW - bu çalışmada KW - c KW - cDNA libraries KW - caffeine KW - caffeine coffea - leaf KW - caffeoylquinic acids KW - café KW - café contém diterpenos da KW - café é composta principalmente KW - candidate genes KW - canephora KW - canephora em condições não KW - carbamide peroxide KW - carbamide peroxide gel KW - carbohydrate KW - carbohydrate demand KW - carboidratos do café KW - carbon allocation KW - carbon partitioning KW - carbopol 940 KW - carotenoid KW - cassia alata l KW - cat_catalase KW - catalase KW - cell KW - cell wall KW - cepta KW - chemcad KW - chemical composition KW - chi KW - chilling KW - chlorogenic acid KW - chlorophyll KW - chlorophyll a fluorescence KW - chlorophyll fluorescence KW - chloroplasts KW - chumphon KW - chumphon province KW - cik ditiro no KW - cite this article KW - citrullus lanatus KW - cjcmm20152206 KW - climate change KW - climate change adaptation KW - climate changes KW - climate extremes KW - clinical protocol KW - clouds KW - co 2 enrichment KW - co 2 saturation point KW - coffea KW - coffea arabica KW - coffea arabica l KW - coffea arabusta KW - coffea canephora KW - coffea sp KW - coffea spp KW - coffea á oxidative stress KW - coffee KW - coffee bean quality KW - coffee beans KW - coffee berry borer KW - coffee berry disease KW - coffee culture KW - coffee genetic resources KW - coffee genotypes KW - coffee is a perennial KW - coffee leaf rust KW - coffee leaf tea KW - coffee oil KW - coffee pest KW - coffee plant KW - coffee plant nutrition KW - coffee production KW - coffee value chain KW - coffee wax KW - coffta arabica KW - cold sensitivity KW - color change KW - com KW - com um particular interesse KW - comercializada no mundo KW - como KW - como os fatores limitantes KW - comparação e integração das KW - compomer KW - componentes típicos encontrados em KW - comportamento estomático e componentes KW - comum KW - concesión de vías KW - conduc- KW - conilon and robusta coffee KW - construction costs KW - conventional coloumn KW - corresponding author KW - corridor KW - crop grown commercially in KW - cropping systems KW - culture KW - cuticle KW - cyt KW - cytochrome KW - cytotoxicity KW - da produção do cafeeiro KW - dan sosial budaya KW - dando- KW - dark cycle KW - daylight KW - dcpip KW - dcpiph 2 KW - de triacilgliceróis KW - de um cafeeiro KW - decoction KW - deficit hídrico prolongado destacam-se KW - density planting KW - dental implant KW - dental prosthesis KW - dentin KW - depigmenting agent KW - depois do petróleo KW - desaturase enzymes KW - desaturation KW - desiccation tolerance KW - detalhados demonstraram novas características KW - developing leaves KW - development KW - dezembro de 2012 KW - dgs KW - di antara aspek yang KW - die-back KW - differential expression KW - diffuse radiation KW - digital planning KW - direct radiation KW - disease KW - diseases KW - distillation KW - diterpenes KW - diterpenos são de interesse KW - do sistema antioxidante KW - doi KW - doib10 KW - dos lipídeos totais KW - dpc KW - dpph KW - drug efficacy KW - dört asma KW - e KW - e desenvolvimento do cafeeiro KW - e plagiotrópicos de c KW - earth systems KW - ecofisiologia do crescimento e KW - ecological management KW - economics spectrum KW - ecosystem services KW - effect á KW - efficiency KW - electrolyte leakage KW - electron transport KW - electron transport rate - KW - ellagic acid KW - em cafeeiros sob estresse KW - em proporção de até KW - email KW - email thickness KW - embryogenic callus KW - enamel KW - enamel hardness surface KW - enzyme activity KW - erixaza79 KW - estadios fenológicos KW - este artigo sumariza os KW - esteróis e KW - estimating KW - estruturais tanto nos galactomananos KW - ests KW - ethanol KW - ethanol-water KW - ethiopia KW - ethnobotany KW - ethnomedicine KW - excretion KW - existe uma comprovada relação KW - extract KW - extraction method KW - extractive colomn KW - factors affecting the KW - família dos kaurenos KW - farmaseutik KW - fatty acid methyl esters KW - fax 351-1-3631085 KW - fisiologia e propriedades KW - floración KW - flowering KW - fluorescence quenching KW - fluorometry KW - food web KW - for KW - for submission to KW - fotossíntese de folhas individuais KW - freezing tolerance KW - frontiers in plant science KW - frontiersin KW - fruit KW - functio KW - function KW - functional trait KW - functional traits KW - g s KW - galactomannans KW - gap KW - gas exchange KW - gas exchanges KW - gel KW - gel formulation KW - gelling agent KW - gene expression KW - genetic breeding KW - genotipinde düşük gece sıcaklığına KW - germination KW - germplasm KW - giomer KW - glycolic acid KW - gmail KW - good agricultural practices KW - green beans KW - grown under five levels KW - growth KW - guaiacol peroxidase KW - heat stress KW - heat-shock factor KW - heat-shock protein KW - heat-stable proteome KW - hidrogen peroxide KW - high light KW - high performance liquid chromatography KW - high temperatures KW - histolocalization KW - historical KW - home bleaching KW - hp 085260070079 KW - hpfm KW - hr KW - humedad relativa KW - hydraulic architecture KW - hydraulic conductance KW - hydrocarbons KW - hydrogen peroxide KW - hypostomatous KW - hídrico KW - icle KW - implementation of good agricultural KW - improvement of coffee plant KW - in office bleaching KW - in- KW - incisor KW - increased from KW - industrial application KW - infraestructura vial KW - inst KW - instances requires KW - integrated pest management KW - intercambio gaseoso KW - intermediate seed KW - intermittent light KW - internal audit KW - intraspecific trait variation KW - intraspecific variation KW - irrigadas e irrigadas KW - j KW - jackfruit leaf KW - jalan t KW - jika kita menggunakan indikator KW - kembang bulan KW - kesehatan KW - konsumsi KW - landrace KW - late maturation KW - late-embryogenesis abundant protein KW - lcp KW - leaf KW - leaf economics spectrum KW - leaf explants KW - leaf morphological traits KW - leaf photosynthesis KW - leaf scald KW - leaf temperature KW - leaf thickness KW - leaf trait KW - leaf wetting KW - learning KW - learning outcome KW - leaves KW - lemon squeeze KW - light KW - light absorption model KW - light compensating point - KW - light intensity á co KW - light quality KW - light saturating point - KW - lipid metabolism KW - lipid peroxidation KW - low light KW - lsp KW - lycopene compounds KW - maceration and reflux method KW - made tea quality KW - mahogany seeds KW - mais recentes desenvolvimentos nas KW - malondialdehyde KW - management KW - marker-assisted selection KW - martin gibbs á co KW - masahiro yamao KW - mature leaves of coffee KW - mda_malondialdehyde KW - medicine KW - melasma KW - mellitusc complicationc traditional chinese KW - membrane lipids KW - mesophyll conductance KW - metabolism KW - metabolomics KW - method of exctracting KW - mf vol 16 no KW - microalgae KW - microspectro- KW - mineral dynamics KW - models KW - moleculares dos carboidratos do KW - morphology KW - mozambique KW - my KW - n metabolism KW - n-hexane KW - n-methyltransferase KW - na-cmc KW - needs and level of KW - nesta revisão KW - net assimilation rate (NAR) KW - net photosynthesis KW - net photosynthesis was measured KW - net photosynthetic rate KW - new phytologist KW - nitrogen KW - nitrogen compounds KW - nitrogen starvation KW - no KW - nonconsumptive effects KW - nonhuman KW - nonstructural carbohydrates KW - normal distribution KW - nos polisacarídeos presentes nas KW - nunes KW - nutrient accumulation KW - o cafeeiro KW - o chamado oleo de KW - o crescimento KW - o objetivo foi avaliar KW - of radiation from 100 KW - on the rate of KW - one sample test KW - operating temperature KW - operating time KW - optimation KW - org KW - organic matter KW - organic pollutants KW - os KW - oxidative stress KW - p-1301 lisboa KW - pH KW - packyrhizus ahipa KW - palisade tissue length KW - par KW - para o cafeeiro KW - paraquat KW - paredes celulares KW - pasta gigi pemutih KW - payback time KW - pekerjaan KW - pendidikan KW - pericarp of mangosteen KW - perilaku pemeliharaan kesehatan gigi KW - peroxidation KW - perumahan KW - peuniti kota banda aceh KW - pewarnaan gigi eksternal KW - phe KW - phenol KW - phenolic acid KW - phenolics KW - phenols KW - pho- KW - photoinhibition KW - photoperiodic variation KW - photophosphorylation á KW - photoprotection KW - photosyn- KW - photosynthesis KW - photosynthesis per unit leaf KW - photosynthesis á shading KW - photosynthetic acclimation KW - photosynthetic capacity under c0 KW - photosynthetic induction kinetics KW - photosynthetic yield improvement KW - photosynthetically active radiation KW - photosynthetically active radiation - KW - photosystem KW - phycoremediation KW - physical characteristic gel KW - physical stability KW - physiological change KW - physiological changes KW - physiology KW - pineapple KW - piper betle KW - plagiotropic branches KW - plant KW - plant architecture KW - plant cell culture KW - plant regeneration KW - plant regeneration via KW - plantation patterns KW - planting designs KW - plasticity KW - plena ex- KW - ploidy level KW - pnmax KW - pongthong pongvinyoo KW - populasi KW - por KW - posición solar KW - positiva entre fechamento estomático KW - potassium management KW - potato plants KW - ppf saturation point KW - practices KW - primary productivity KW - principal component analysis KW - productividad KW - professional audit KW - proline KW - proteins KW - pseudacteon KW - published fifty or more KW - purine alkaloid KW - purine alkaloid physiology KW - purine alkaloids and temperature KW - quantum yield KW - radiação solar incidindo em KW - ramalho and m KW - ramets KW - ratio KW - real-time PCR KW - reduced 2 KW - rendement KW - resistance KW - resultados dos estudos químicos KW - resumo KW - rinaldi KW - roasted coffee KW - roasting KW - robusta coffee KW - root economics spectrum KW - roots KW - s KW - salicylic acid KW - security KW - seed KW - seedlings KW - sekolah dasar KW - semente de café KW - senggani leaves KW - sering digunakan sebagai indikator KW - servicios ecosistémicos KW - shade KW - shade tolerance KW - shading KW - sicklepod KW - singlet‐oxygen KW - situs lumpang batu KW - sl KW - sld KW - sod_superoxide dismutase KW - somatic embryo induction KW - somatic embryogenesis KW - sombrío KW - sp KW - space agriculture KW - specific leaf area KW - spectrophotometry KW - spent coffee grounds KW - starch KW - staritsky KW - stolon stretch KW - stomata KW - stomatal characteristics KW - stomatal conductance KW - stomatal length KW - stomatal limitation - sla KW - stomatal ratio KW - stomatal resistance KW - strawberry KW - stress KW - stress resistance KW - sucrose KW - sugars KW - sun KW - sun and shade plants" KW - sunflecks KW - superoxide dismutase KW - suspension KW - sustainability KW - sıcaklığına toleransı belirleyen özellikler KW - tancia estomática KW - tapada da ajuda KW - tasa fotosintética neta KW - taxas KW - tea KW - tea soil KW - teeth calcium levels KW - teeth colouring KW - teeth discoloration KW - teeth whitening KW - temperaturas extremas e o KW - temperature KW - test KW - thailand KW - the actual aspect of KW - the compressive strength KW - the effect of irradiance KW - the rate of light-saturated KW - theobromine KW - there is a large KW - thermal de‐excitation KW - thylakoid KW - tingkat pengetahuan KW - tissue culture should be KW - titrimetry KW - to 5 KW - tocoferóis KW - todo óleo vegetal comestível KW - tolerance markers KW - toleransı belirleyen KW - toleransı ile i̇lişkilidir KW - tomatoes KW - tooth color KW - tooth discoloration KW - tosynthesis KW - tourism KW - traditional plant use KW - trait coordination KW - trait-based ecology KW - trait-meditated KW - transcript profiling KW - transcriptome KW - transpiration KW - trees KW - triazole KW - triose phosphate dehydrogenases á KW - tropical areas KW - tropical ecology KW - ukuran kesejahteraan adalah pendapatan KW - uma planta dificulta a KW - unsa- KW - uptake KW - v16i2 KW - vRFd-values KW - vacuum infiltration KW - vegetativo de ramos ortotrópicos KW - vein KW - very effective for the KW - vestigaqao cientifica tropical - KW - vitamin c KW - vitis vinifera KW - vitis vinifera l KW - vol KW - vías de cuarta generación. KW - warna gigi KW - water deficit KW - water stress KW - watermelon KW - watermelon fruit extract KW - watermelons KW - which is difficult of KW - whistleblowing actions KW - winter-wheat KW - work ethics KW - wound healing KW - www KW - xanthophyll cycle KW - xanthophylls KW - y défi- KW - years ago KW - yield KW - zeaxanthin KW - à produtividade de coffea KW - á photoinhibition á KW - áreas de química KW - é a principal mercadoria KW - özet KW - ΕΡΨΣ-ΑΓΑΠΗ KW - β-carotene KW - กษ KW - ว KW - วิทย PY - 2019 SN - 9788578110796 SP - 5 EP - 7 TI - Impactos De La Construcción De Las Vias De Cuarta Generación En Colombia Sobre La Biodiversidad Y Sus Servicios Ecosistémicos T2 - Journal of Chemical Information and Modeling UR - http://jurnal.globalhealthsciencegroup.com/index.php/JPPP/article/download/83/65%0Ahttp://www.embase.com/search/results?subaction=viewrecord&from=export&id=L603546864%5Cnhttp://dx.doi.org/10.1155/2015/420723%0Ahttp://link.springer.com/10.1007/978-3-319-76 VL - 8 ER - TY - JOUR AB - El propósito del estudio fue examinar los cambios vividos por los pobladores de los sectores que conforman la vía intercomunitaria Quisapincha-Pasa, así como su nivel de satisfacción de la obra. Se tomó como referencia los cuestionarios desarrollados por el Instituto Nacional de Estadísticas y Censos (INEC), tanto el Censo de Población y Vivienda efectuado en 2010 como la Encuesta de Condiciones de Vida correspondiente al periodo 2013-2014; además, se definieron dos dimensiones: dimensión uno, Nivel de Satisfacción y Nivel de Insatisfacción; dimensión dos, Nivel Ni Satisfecho y Nivel Ni Insatisfecho. El cuestionario fue aplicado a una muestra de 401 personas. Los efectos de la obra pública recogidos mostraron que la construcción de la red vial intercomunitaria Quisapincha-Pasa ha contribuido a la accesibilidad, movilidad y acceso a servicios básicos por parte de los pobladores, así como una mejora en el tipo de vivienda, el acceso a distintos medios de transporte y de servicios básicos. Todo ello, lo recoge el índice de calidad de vida, que alcanzó un 12,49%, esto es que existe una mejora en la calidad de vida de los pobladores, tomando como referencia el año 2010. Palabras Clave: Obra pública, calidad de vida, impacto socioeconómico, vías intercomunitarias. AU - Jerez-Calero, Maria Elena AU - Llerena-Cepeda, Sonnia Lorena AU - Zamora-Sánchez, Ruth DO - 10.33890/innova.v3.n3.2018.445 IS - 3 KW - calidad de vida KW - impacto socioeconómico KW - obra pública KW - vías PY - 2018 SP - 95 EP - 108 TI - Estudio de satisfacción poblacional a la red vial intercomunitaria Quisapincha -Pasa T2 - INNOVA Research Journal VL - 3 ER - TY - JOUR PY - 2009 TI - Informe 4 (120-2014) ER - TY - JOUR AU - Montero, Rafael AU - Edouard, Fabrice IS - 1 PY - 2015 SP - 1 EP - 51 TI - Ficha Metodológica Diseño y procesamiento de las encuestas a nivel de los hogares ER - TY - JOUR AB - El presente proyecto se realiza por encargo del Departamento de Conservación de Montes de la Consejería de Medio Ambiente, Vivienda y Ordenación del Territorio de la Comunidad de Madrid. Para poder acceder a la zona del monte en la que está próximo el tra tamiento de corta correspondiente y efectuar su aprovechamiento, es necesaria la construcción de una Vía de Saca que permita realizar dichos trabajos, así como proporcionar acceso para la gestión y mantenimiento del monte. Mediante este proyecto se realizará un estudio pormenorizado de las alternativas de trazado y características, minimizando la suma de los costes de establecimiento, conservación y explotación. Además se valorarán los posibles impactos positivos y negativos, intentando eliminar o minimizar el efecto de estos últimos, adoptando medidas correctoras o compensatorias, a lo largo de la vida útil de la vía. AU - Ronquillo-Muñóz, María del Mar PY - 2011 SP - 507 EP - 507 TI - Proyecto de Construcción de una vía de Saca en el monte nº 39 de U.P. “Pinar y agregados”, T.M. de Guadarrama (Madrid) UR - http://oa.upm.es/7067/1/PFC_MAR_RONQUILLO.pdf ER - TY - JOUR AB - This research shows the development of a methodology to justify the construction of an overpass intersection, based on the probability distribution of Poisson, where variables such as traffic volume, speed, maneuvering time and the geometry of the intersection were conjoined to determine the probability that two vehicles are intersected. This methodology allows decision makers to assess the appropriate time where road safety at an intersection is exceeded, in terms of road capacity, geometry and other traffic variables included in the model. Although the results could not be validated by statistical accident in the case studies, graphs obtained had a behavior in accordance with the objectives and the hypothesis of this project, ensuring that the product of this research is a useful tool to justify a preventive technique to improve an intersection, which could be an overpass intersection geometry. The literature review also allows an overview of the current state of the art about accident rates, the importance of the intersections in the road system as they are if neglected can contribute to increasing the rate of traffic accidents, as well as current overview methodologies for evaluating intersections in terms of safety AU - Mendoza Sánchez, Juan Fernando AU - Quezada Bermúdez, Favio M. AU - Trejo Trejo, José Adrián IS - 436 PY - 2015 SP - 92 EP - 92 TI - Propuesta metodológica para justificar la construcción de intersecciones a desnivel T2 - Sanfandila UR - http://www.imt.mx/archivos/Publicaciones/PublicacionTecnica/pt436.pdf ER - TY - JOUR AB - This research shows the development of a methodology to justify the construction of an overpass intersection, based on the probability distribution of Poisson, where variables such as traffic volume, speed, maneuvering time and the geometry of the intersection were conjoined to determine the probability that two vehicles are intersected. This methodology allows decision makers to assess the appropriate time where road safety at an intersection is exceeded, in terms of road capacity, geometry and other traffic variables included in the model. Although the results could not be validated by statistical accident in the case studies, graphs obtained had a behavior in accordance with the objectives and the hypothesis of this project, ensuring that the product of this research is a useful tool to justify a preventive technique to improve an intersection, which could be an overpass intersection geometry. The literature review also allows an overview of the current state of the art about accident rates, the importance of the intersections in the road system as they are if neglected can contribute to increasing the rate of traffic accidents, as well as current overview methodologies for evaluating intersections in terms of safety AU - Carreteras, De AU - Delphi, Método AU - Montero, Rafael AU - Edouard, Fabrice AU - Transversal, Eje Ferroviario AU - Ute, Tramo I I AU - L-, Analiter S AU - Red Española de Ciudades por el Clima AU - Jerez-Calero, Maria Elena AU - Llerena-Cepeda, Sonnia Lorena AU - Zamora-Sánchez, Ruth AU - Ronquillo-Muñóz, María del Mar AU - Mendoza Sánchez, Juan Fernando AU - Quezada Bermúdez, Favio M. AU - Trejo Trejo, José Adrián DO - 10.33890/innova.v3.n3.2018.445 IS - 3 KW - calidad de vida KW - impacto socioeconómico KW - obra pública KW - vías PY - 2015 SP - 1 EP - 51 TI - Diseño y Elaboración de Encuestas Locales de Movilidad Sostenible T2 - Sanfandila UR - http://www.imt.mx/archivos/Publicaciones/PublicacionTecnica/pt436.pdf UR - http://oa.upm.es/7067/1/PFC_MAR_RONQUILLO.pdf VL - 3 ER - TY - JOUR TI - Anexo A. Encuesta ER - TY - JOUR AU - Purchena, Baza TI - ESTUDIO DE VIABILIDAD PARA LA CONSTRUCCIÓN , CONSERVACIÓN Y EXPLOTACIÓN DE LA AUTOVÍA DEL ALMANZORA EN LA A-334 . TRAMO : ER - TY - JOUR AU - Transversal, Eje Ferroviario AU - Ute, Tramo I I AU - L-, Analiter S PY - 2005 SP - 93 EP - 114 TI - EsIA del Proyecto de Duplicación de Plataforma del Eje Ferroviario Transversal de Andalucía, Tramo: Marchena-Osuna. Tramo II UTE: AUDING-INYSUR ER - TY - JOUR AU - Carreteras, De AU - Delphi, Método IS - 3 PY - 2002 TI - Guanajuato, Gto., México VL - 12 ER - TY - JOUR AU - Red Española de Ciudades por el Clima PY - 2010 SP - 95 EP - 95 TI - Diseño y Elaboración de Encuestas Locales de Movilidad Sostenible ER - TY - GEN AB - Soil erosion is affected by rainfall temporal patterns and intensity variability. In vineyards, machine traffic is implemented with particular intensity from late spring to harvest, and it is responsible for soil compaction, which likely affects soil hydraulic properties, runoff, and soil erosion. Additionally, the hydraulic and physical properties of soil are highly influenced by vineyards' inter-rows soil management. The effects on soil compaction and both hydrological and erosional processes of machine traffic were investigated on a sloping vineyard with different inter-row soil managements (tillage and permanent grass cover) in the Alto Monferrato area (Piedmont, NW Italy). During the investigation (November 2016-October 2018), soil water content, rainfall, runoff, and soil erosion were continuously monitored. Field-saturated hydraulic conductivity, soil penetration resistance, and bulk density were recorded periodically in portions of inter-rows affected and not affected by the machine traffic. Very different yearly precipitation characterized the observed period, leading to higher bulk density and lower infiltration rates in the wetter year, especially in the tilled vineyard, whereas soil penetration resistance was generally higher in the grassed plot and in drier conditions. In the wet year, management with grass cover considerably reduced runoff (76%) and soil loss (-83%) compared to tillage and in the dry season. Those results highlight the need to limit the tractor traffic, in order to reduce negative effects due to soil compaction, especially in tilled inter-rows. AU - Congreso de Colombia IS - August KW - Affine Horton infiltration equations KW - Agroforestry KW - Amhara KW - Biodiversity KW - Climate change KW - Desertificat ion KW - Distributed model KW - Drought KW - Drylands KW - Erosion KW - Ethiopia KW - Farmers' knowledge KW - Fowlers Gap KW - GIS KW - GRASS KW - Global environment KW - Hydraulic conductivity KW - Hydrological properties KW - Infiltration KW - Kiremt KW - Land degradation KW - Natural Resources KW - New York KW - Rainfall Trends KW - Rainfall intermittency KW - Runoff KW - Saturation-excess KW - Soil Erosion KW - Soil erosion indicators KW - Soil management KW - Soil moisture routing model (SMR) KW - Soil water conservation KW - Spatio-temporal KW - Subsurface lateral flow KW - Sudan KW - Synergies KW - Tractor traffic KW - UN environmental conventions KW - Variable source hydrology KW - Vineyards KW - competitive advantage KW - degradation KW - domestic market KW - economic growth KW - economics KW - ethiopian KW - globalization KW - government KW - industrialisation KW - land cover KW - land use KW - manufacturing KW - marketed surplus KW - modelling KW - multiple linear KW - on site effect KW - potato KW - poverty KW - rainwater harvesting KW - raw material KW - sedimentation KW - soil KW - soil erosion KW - upper nile basin KW - upstream management PY - 1993 SP - 12 EP - 42 TI - Ley 70 de 1993 VL - 5 ER - TY - GEN AB - Plants and soils from a natural thorium and rare-earth element occurrence (Morro do Ferro, Brazil) were analyzed by alpha spectrometry (Th) and ICP-AES (REE), after pre-concentration of the elements by solvent extraction, co-precipitation and ion exchange procedures. Leaching experiments with humic acid solutions and different soils were performed to estimate the fraction of elements biologically available. High concentrations of the light rare-earth elements (LREE) and of Th, reaching some hundreds of μg/g-ash, were measured in plant leaves from the areas of the highest concentration of these elements in soil and in near-surface waters. Chondrite normalized REE plots of plant leaves and corresponding soils are very similar, suggesting that there is no significant fractionation between the REE during uptake from the soil solution and incorporation into the leaves. However, Ce-depletion was observed for some plant species, increasing for Solanum ciliatum in the sequence: leaves 0.99). Conclusions: Real-time USG guidance improves success rates, reduces the number of attempts and decreases the complications associated with CVC insertion, especially for the IJV, and should become the standard of care in intensive care. AU - Palepu, Gopal AU - Deven, Juneja AU - Subrahmanyam, M. AU - Mohan, S. DO - 10.4103/0971-3026.54877 IS - 3 KW - Central venous catheters KW - Internal jugular vein KW - Subclavian vein KW - Ultrasound-guided central lines PY - 2009 SP - 191 EP - 198 TI - Impact of ultrasonography on central venous catheter insertion in intensive care T2 - Indian Journal of Radiology and Imaging VL - 19 ER - TY - JOUR AB - : Background: Central venous catheters (CVCs) can help with diagnosis and treatment of the critically ill. The catheter may be placed in a large vein in the neck (internal jugular vein), upper chest (subclavian vein) or groin (femoral vein). Whilst this is beneficial overall, inserting the catheter risks arterial puncture and other complications and should be performed with as few attempts as possible. Traditionally, anatomical ?landmarks? on the body surface were used to find the correct place in which to insert catheters, but ultrasound imaging is now available. A Doppler mode is sometimes used to supplement plain ?two-dimensional? ultrasound.Objectives: The primary objective of this review was to evaluate the effectiveness and safety of two-dimensional (imaging ultrasound (US) or ultrasound Doppler (USD)) guided puncture techniques for insertion of central venous catheters via the internal jugular vein in adults and children. We assessed whether there was a difference in complication rates between traditional landmark-guided and any ultrasound-guided central vein puncture.Our secondary objectives were to assess whether the effect differs between US and USD; whether the effect differs between ultrasound used throughout the puncture ('direct') and ultrasound used only to identify and mark the vein before the start of the puncture procedure (indirect'); and whether the effect differs between different groups of patients or between different levels of experience among those inserting the catheters.Search methods: We searched the Central Register of Controlled Trials (CENTRAL) (2013, Issue 1), MEDLINE (1966 to 15 January 2013), EMBASE (1966 to 15 January 2013), the Cumulative Index to Nursing and Allied Health Literature (CINAHL) (1982 to 15 January 2013 ), reference lists of articles, 'grey literature' and dissertations. An additional handsearch focused on intensive care and anaesthesia journals and abstracts and proceedings of scientific meetings. We attempted to identify unpublished or ongoing studies by contacting companies and experts in the field, and we searched trial registers. We reran the search in August 2014. We will deal with identified studies of interest when we update the review.Selection criteria: We included randomized and quasi-randomized controlled trials comparing two-dimensional ultrasound or Doppler ultrasound with an anatomical 'landmark' technique during insertion of internal jugular venous catheters in both adults and children.Data collection and analysis: Three review authors independently extracted data on methodological quality, participants, interventions and outcomes of interest using a standardized form. A priori, we aimed to perform subgroup analyses, when possible, for adults and children, and for experienced operators and inexperienced operators.Main results: Of 735 identified citations, 35 studies enrolling 5108 participants fulfilled the inclusion criteria. The quality of evidence was very low for most of the outcomes and was moderate at best for four of the outcomes. Most trials had an unclear risk of bias across the six domains, and heterogeneity among the studies was significant.Use of two-dimensional ultrasound reduced the rate of total complications overall by 71% (14 trials, 2406 participants, risk ratio (RR) 0.29, 95% confidence interval (CI) 0.17 to 0.52; P value < 0.0001, I� = 57%), and the number of participants with an inadvertent arterial puncture by 72% (22 trials, 4388 participants, RR 0.28, 95% CI 0.18 to 0.44; P value < 0.00001, I� = 35%). Overall success rates were modestly increased in all groups combined at 12% (23 trials, 4340 participants, RR 1.12, 95% CI 1.08 to 1.17; P value < 0.00001, I� = 85%), and similar benefit was noted across all subgroups. The number of attempts needed for successful cannulation was decreased overall (16 trials, 3302 participants, mean difference (MD) -1.19 attempts, 95% CI -1.45 to -0.92; P value < 0.00001, I� = 96%) and in all subgroups. Use of two-dimensional ultrasound increased the chance of success at the first attempt by 57% (18 trials, 2681 participants, RR 1.57, 95% CI 1.36 to 1.82; P value < 0.00001, I� = 82%) and reduced the chance of haematoma formation (overall reduction 73%, 13 trials, 3233 participants, RR 0.27, 95% CI 0.13 to 0.55; P value 0.0004, I� = 54%). Use of two-dimensional ultrasound decreased the time to successful cannulation by 30.52 seconds (MD -30.52 seconds, 95% CI -55.21 to -5.82; P value 0.02, I� = 97%). Additional data are available to support use of ultrasound during, not simply before, line insertion.Use of Doppler ultrasound increased the chance of success at the first attempt by 58% (four trials, 199 participants, RR 1.58, 95% CI 1.02 to 2.43; P value 0.04, I� = 57%). No evidence showed a difference for the total numbers of perioperative and postoperative complications/adverse events (three trials, 93 participants, RR 0.52, 95% CI 0.16 to 1.71; P value 0.28), the overall success rate (seven trials, 289 participants, RR 1.09, 95% CI 0.95 to 1.25; P value 0.20), the total number of attempts until success (two trials, 69 participants, MD -0.63, 95% CI -1.92 to 0.66; P value 0.34), the overall number of participants with an arterial puncture (six trials, 213 participants, RR 0.61, 95% CI 0.21 to 1.73; P value 0.35) and time to successful cannulation (five trials, 214 participants, each using a different definition for this outcome; MD 62.04 seconds, 95% CI -13.47 to 137.55; P value 0.11) when Doppler ultrasound was used. It was not possible to perform analyses for the other outcomes because they were reported in only one trial.Authors' conclusions: Based on available data, we conclude that two-dimensional ultrasound offers gains in safety and quality when compared with an anatomical landmark technique. Because of missing data, we did not compare effects with experienced versus inexperienced operators for all outcomes (arterial puncture, haematoma formation, other complications, success with attempt number one), and so the relative utility of ultrasound in these groups remains unclear and no data are available on use of this technique in patients at high risk of complications. The results for Doppler ultrasound techniques versus anatomical landmark techniques are also uncertain. US-: http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD006962.pub2/abstract AU - Brass, P AU - Hellmich, M AU - Kolodziej, L AU - Schick, G AU - Af, Smith AU - Patrick, Brass AU - Martin, Hellmich AU - Laurentius, Kolodziej AU - Guido, Schick AU - F, Smith Andrew AU - Brass, P AU - Hellmich, M AU - Kolodziej, L AU - Schick, G AU - Af, Smith AU - Patrick, Brass AU - Martin, Hellmich AU - Laurentius, Kolodziej AU - Guido, Schick AU - F, Smith Andrew DO - 10.1002/14651858.CD011447.www.cochranelibrary.com IS - 1 PY - 2015 TI - Ultrasound guidance versus anatomical landmarks for subclavian or femoral vein catheterization SO-: Cochrane Database of Systematic Reviews YR-: 2015 NO-: 1 T2 - Cochrane Database of Systematic Reviews ER - TY - JOUR AB - Central venous port devices made of two different polymeric materials, thermoplastic polyurethane (TPU) and silicone rubber (SiR), were compared due their material properties. Both naïve catheters as well as catheters after removal from patients were investigated. In lab experiments the influence of various chemo-therapeutic solutions on material properties was investigated, whereas the samples after removal were compared according to the implanted time in patient. The macroscopic, mechanical performance was assessed with dynamic, specially adapted tests for elasticity. The degradation status of the materials was determined with common tools of polymer characterisation, such as infrared spectroscopy, molecular weight measurements and various methods of thermal analysis. The surface morphology was analysed using scanning electron microscopy. A correlation between material properties and clinical performance was proposed. The surface morphology and chemical composition of the polyurethane catheter materials can potentially result in increased susceptibility of the catheter to bloodstream infections and thrombotic complications. The higher mechanic failure, especially with increasing implantation time of the silicone catheters is related to the lower mechanical performance compared to the polyurethane material as well as loss of barium sulphate filler particles near the surface of the catheter. This results in preformed microscopic notches, which act as predetermined sites of fracture. AU - Braun, Ulrike AU - Lorenz, Edelgard AU - Weimann, Christiane AU - Sturm, Heinz AU - Karimov, Ilham AU - Ettl, Johannes AU - Meier, Reinhard AU - Wohlgemuth, Walter A. AU - Berger, Hermann AU - Wildgruber, Moritz DO - 10.1016/j.jmbbm.2016.08.002 KW - Central venous access port KW - Complication KW - Mechanical testing KW - Polyurethane KW - Silicon rubber KW - Structure property relationship PB - Elsevier PY - 2016 SP - 281 EP - 291 TI - Mechanic and surface properties of central-venous port catheters after removal: A comparison of polyurethane and silicon rubber materials T2 - Journal of the Mechanical Behavior of Biomedical Materials UR - http://dx.doi.org/10.1016/j.jmbbm.2016.08.002 VL - 64 ER - TY - JOUR AB - Background: The ultrasound (US)-guided technique has been recommended for central venous catheter (CVC) placement in critical care. However, several surveys have shown that the majority of physicians continue to perform landmark procedures. In our region, we have implemented special courses to promote the use of US with formal training and simulators. Ultrasound machines have also been installed in almost every ICU in our area. We designed a survey to investigate whether the training program established for years and the widespread of ultrasound devices in the ICU of our region will be associated with a high rate of physicians performing US procedures. Methods: A survey comprising 14 questions was designed to elicit information on training in US techniques, the use of US for CVC placement, reasons for nonuse of US and their opinion concerning the need to teach the landmark technique to residents. This survey was electronically sent to every physician of the BoReal study group (32 ICUs located in the North West of France). Results: We received 190 responses (response rate 66 %) including 34 % of residents. Only 11 % of respondents reported the absence of training in the US technique, and 3 % reported they did not have access to an ultrasound machine. A total of 68 % declared “always” (18 %) or “almost always” (50 %) using US to guide CVC placement. Our results are better than those of previous surveys. The main reasons why physicians did not use the US technique were that they thought that US guidance was unnecessary (36 %) or because the ultrasound machine was not immediately available (33 %). Ninety-one percentages think that the landmark technique should still be taught to the residents. A higher proportion of residents compared to seniors declared that they always or almost always used the US technique. Conclusion: Training in ultrasound techniques and the widespread availability of ultrasound machines in ICUs seem to improve the rate of US procedures. However, despite strong scientific evidence a proportion of physicians continue to consider the landmark technique as an alternative to US. Training and education are potentially still the best ways to overcome such barriers or conviction. AU - Maizel, Julien AU - Bastide, Marie Anaïs AU - Richecoeur, Jack AU - Frenoy, Eric AU - Lemaire, Christian AU - Sauneuf, Bertrand AU - Dupont, Hervé AU - Tamion, Fabienne AU - Nseir, Saad AU - Du Cheyron, Damien AU - the BoReal Study group AU - Alvado, G. AU - Andrejak, C. AU - Azera, P. AU - Barjon, G. AU - Boulle, C. AU - Delastre, O. AU - Delerue, V. AU - Detave, M. AU - Dubosq, P. AU - Elbaaj, J. AU - Fiani, M. AU - Jeanjean, P. AU - Lambiotte, F. AU - Leroy, O. AU - Moubarak, M. AU - Pordes, R. AU - Renaud, E. AU - Rigaud, J. P. AU - Rivière, A. AU - Sahri, R. AU - Saint Leger, P. AU - Thevenin, D. AU - Vanderlinden, T. DO - 10.1186/s13613-016-0177-x IS - 1 KW - Central venous catheter KW - Education KW - Ultrasound PY - 2016 TI - Practice of ultrasound-guided central venous catheter technique by the French intensivists: a survey from the BoReal study group T2 - Annals of Intensive Care VL - 6 ER - TY - GEN TI - Información sobre el catéter venoso central (CVC) para pacientes pediátricos | Memorial Sloan Kettering Cancer Center UR - https://www.mskcc.org/es/cancer-care/patient-education/about-your-central-venous-catheter-peds ER - TY - GEN TI - Tecnica de punción subclavia – ingrid101011 UR - https://ingrid101011.wordpress.com/2018/02/24/tecnica-de-puncion-subclavia/ ER - TY - GEN AB - Hipótesis de trabajo: -La cateterización de una vía venosa central es una técnica invasiva, no exenta de complicaciones. -La cateterización venosa central presenta distintas tasas de complicaciones en dependencia de la localización anatómica seleccionada para su abordaje. -Existen diversos factores anatómicos, clínicos o del propio paciente que pueden influir en la aparición de estas complicaciones. Objetivos: -Estudiar la relación entre la vía de abordaje y las complicaciones inmediatas y diferidas derivadas de la técnica. -Valorar la existencia de factores de riesgo que aumenten las tasas de complicaciones agudas y diferidas tales como abordaje seleccionado, número de punciones, personal que realiza la técnica, anatomía desfavorable, y extrema urgencia. Métodos: Se recogieron 316 procedimientos consecutivos, en la UCI del H. San Jorge de Huesca, entre Junio de 2013 y Abril de 2015. Se realizó un estudio comparativo, prospectivo de las distintas vías de abordaje venoso central (Yugular, Femoral, Subclavia, Axilar) con la aparición de complicaciones inmediatas, tales como punción arterial, neumotórax, no canalización, malposición catéter, sangrado pericateter y mixtas, y complicaciones diferidas, como complicaciones mecánicas ( trombosis venosa profunda, hematoma, rotura de catéter, arrancamiento, sangrado, obstrucción), infecciosas (bacteriemia y fungemia) y complicaciones menores (flebitis, infección del punto de punción y colonización del catéter). Para el estudio de diferencias significativas respecto a Factor de Riesgo se utilizó el test de Chi cuadrado. Resultados: Se obtuvo una media de 1,9 punciones por vía, un 22% de los casos precisó 3 o más punciones para su canulación. En el 53% de los casos se realizó una RX de control, en un 11% de los casos se utilizó guía ecográfica. -Respecto a complicaciones agudas, tanto la localización de la vía, como el número de punciones, y la anatomía desfavorable son aspectos que están relacionados con la existencia de diferencias significativas. -Respecto a complicaciones diferidas, únicamente la localización de la vía repercute en la existencia de diferencias significativas, aunque sólo para el caso de complicaciones de tipo mecánico. -La localización de la vía influye de manera significativa tanto en las complicaciones agudas (neumotórax), como diferidas (mecánicas), no así el personal que realiza la técnica, ni los posibles casos de extrema urgencia. El número de punciones y anatomía desfavorable influyen en… AU - Cambra Fierro, R.P. PB - Universidad de Zaragoza PY - 2016 TI - Canulación de vías centrales: estudio de las complicaciones inmediatas y diferidas tras la colocación de los catéteres venosos centrales y su relación con la vía de abordaje ER - TY - JOUR AU - Cvnt, Los AU - Cvt, Los PY - 2018 SP - 138 EP - 181 TI - CAPÍTULO 6. Catéteres venosos centrales ER - TY - JOUR AB - Central venous catheters (CVCs) are used with increasing frequency in the intensive care unit and in general medical wards. Catheter infection, the most frequent complication of CVC use, is associated with increased morbidity, mortality, and duration of hospital stay. Risk factors in the development of catheter colonisation and bloodstream infection include patient factors (increased risk associated with malignancy, neutropenia, and shock) and treatment-related factors (increased risk associated with total parenteral nutrition, ICU admission for any reason, and endotracheal intubation). Other risk factors are prolonged catheter indwelling time, lack of asepsis during CVC insertion, and frequent manipulation of the catheter. The most important factor is catheter care after placement. Effects of CVC tunnelling on infection rates depend to a large extent on indwelling time and the quality of catheter care. Use of polyurethane dressings can increase the risk of colonisation compared to regular gauze dressing. Thrombus formation around the CVC tip increases the risk of infection; low-dose anticoagulants may decrease this risk. New developments such as CVC impregnation with antibiotics may reduce the risk of infection. Reducing catheter infection rates requires a multiple-strategy approach. Therefore, ICUs and other locations where CVCs are used should implement strict guidelines and protocols for catheter insertion, care, and maintenance. AU - Polderman, K. H. AU - Girbes, A. R.J. DO - 10.1007/s00134-001-1156-7 IS - 1 KW - Catheter-related bacteraemia KW - Catheter-related sepsis KW - Central venous catheter KW - Colonisation KW - Infectious complications KW - Literature review KW - Preventive strategy PY - 2002 SN - 3120444391 SP - 18 EP - 28 TI - Central venous catheter use: Part 2: Infectious complications T2 - Intensive Care Medicine VL - 28 ER - TY - JOUR AB - Central venous catheters are being increasingly used in both intensive care units and general wards. Their use is associated with both mechanical and infectious complications. This review will focus on short- and medium-term mechanical complications of catheter placement; infectious complications will be discussed in a separate article. The most important risk factors are patient characteristics (morbidity, underlying disease and local anatomy), the expertise of the doctor performing the procedure, and nursing care. Placement aids, such as ultrasound-guided catheter insertion, are also discussed. AU - Polderman, Kees H. AU - Girbes, Armand R. DO - 10.1007/s00134-001-1154-9 IS - 1 KW - Central venous catheters KW - Literature review KW - Location KW - Material KW - Mechanical complications KW - Preventive strategy KW - Risk factors PY - 2002 SN - 3120444391 SP - 1 EP - 17 TI - Central venous catheter use part 1: Mechanical complications T2 - Intensive Care Medicine VL - 28 ER - TY - JOUR AB - Central venous catheters (CVC) are an important tool in the operation room and intensive care unit. The application of CVC is associated with both mechanical and infectious complications. Knowledge and recognition of risk factors and implementation of strict guidelines will help to reduce the number and severity of complications. Catheter-related factors, patient-related factors, selection of the site of puncture and catheter use and care related factors, all play a contributive role in the risk on complications. AU - Girbes, A. R.J. AU - Polderman, K. H. IS - 5 KW - Catheterization, central venous KW - Intensive Care Units KW - Postoperative complications PY - 2003 SP - 330 EP - 332 TI - Mechanical and infectious complications of central venous catheters T2 - Minerva Anestesiologica VL - 69 ER - TY - JOUR AB - The severely infected patient care usually requires the installation of a central venous catheter due to multimedications required. Thrombosis is a common complication of central venous catheters, although often unnoticed. In this report we present the case of this complication and discuss the management. Key words: severely patient, central venous catheter. Resumen La atención del paciente gravemente infectado habitualmente requiere la instalación de un catéter venoso central, debido a la multimedicación que requiere. La trombosis es una complicación común, aunque muchas veces desapercibidas, de los catéteres venosos centrales. En el presente reporte se presenta el caso de esta complicación y se discute el manejo. Palabras claves: paciente grave, cateter venoso central. Introducción Uno de los puntos cardinales en el manejo integral de los pacientes graves es la necesidad de disponer de una vía venosa segura debido a la complejidad del tratamiento. Habitualmente los pacientes críticos reciben múltiples medicaciones por vía intravenosa en forma simultánea (soluciones de hidratación, inotrópicos, antibióticos, transfusiones de sangre y otros derivados biológicos) además de requerir de monitoreo hemodinámico invasivo. De ahí que catéteres venosos centrales se instalan virtualmente en todos los pacientes que ingresan a una unidad de cuidados intensivos. Si bien este procedimiento es necesario (y muchas veces insustituible), no está exento de riesgos. Aun cuando las complicaciones infecciosas asociadas al CVC son la principales, la trombosis asociada al CVC representa un evento indeseable que puede complicar la evolución de los pacientes. AU - Duarte, Mónica AU - Batista, Jorge AU - Arbo, Antonio IS - 1 KW - central venous catheter KW - severely patient PY - 2010 SP - 34 EP - 37 TI - Trombosis asociada a catéter venoso central: reporte de caso T2 - Revista del Instituto de Medicina Tropical VL - 5 ER - TY - JOUR AB - Background Peripherally inserted central catheters (PICCs) are associated with an increased risk of venous thromboembolism. However, the size of this risk relative to that associated with other central venous catheters (CVCs) is unknown. We did a systematic review and meta-analysis to compare the risk of venous thromboembolism associated with PICCs versus that associated with other CVCs. Methods We searched several databases, including Medline, Embase, Biosis, Cochrane Central Register of Controlled Trials, Conference Papers Index, and Scopus. Additional studies were identified through hand searches of bibliographies and internet searches, and we contacted study authors to obtain unpublished data. All human studies published in full text, abstract, or poster form were eligible for inclusion. All studies were of adult patients aged at least 18 years who underwent insertion of a PICC. Studies were assessed with the Newcastle-Ottawa risk of bias scale. In studies without a comparison group, the pooled frequency of venous thromboembolism was calculated for patients receiving PICCs. In studies comparing PICCs with other CVCs, summary odds ratios (ORs) were calculated with a random effects meta-analysis. Findings Of the 533 citations identified, 64 studies (12 with a comparison group and 52 without) including 29 503 patients met the eligibility criteria. In the non-comparison studies, the weighted frequency of PICC-related deep vein thrombosis was highest in patients who were critically ill (13·91%, 95% CI 7·68- 20·14) and those with cancer (6·67%, 4·69-8·64). Our meta-analysis of 11 studies comparing the risk of deep vein thrombosis related to PICCs with that related to CVCs showed that PICCs were associated with an increased risk of deep vein thrombosis (OR 2·55, 1·54-4·23, p<0·0001) but not pulmonary embolism (no events). With the baseline PICC-related deep vein thrombosis rate of 2·7% and pooled OR of 2·55, the number needed to harm relative to CVCs was 26 (95% CI 13-71). Interpretation PICCs are associated with a higher risk of deep vein thrombosis than are CVCs, especially in patients who are critically ill or those with a malignancy. The decision to insert PICCs should be guided by weighing of the risk of thrombosis against the benefit provided by these devices. © 2013 Elsevier Ltd. AU - Chopra, Vineet AU - Anand, Sarah AU - Hickner, Andy AU - Buist, Michael AU - Rogers, Mary A.M. AU - Saint, Sanjay AU - Flanders, Scott A. DO - 10.1016/S0140-6736(13)60592-9 IS - 9889 PB - Elsevier Ltd PY - 2013 SP - 311 EP - 325 TI - Risk of venous thromboembolism associated with peripherally inserted central catheters: A systematic review and meta-analysis T2 - The Lancet UR - http://dx.doi.org/10.1016/S0140-6736(13)60592-9 VL - 382 ER - TY - BOOK AB - … Akses terbuka (open access), memberi keleluasaan kepada siapapun yang membutuhkan informasi khususnya melalui sumber daya … Dalam akses terbuka (open access), informasi dengan teknologi digital ada kebebasan untuk mengakses bagi siapa saja yang membutuhkan … AU - Perez-Lescure, Javier PY - 1384 SP - 121 EP - 121 TI - Manual de tecnicas y procedimientos en urgencias de pediatria para enfermeria y medicina ER - TY - JOUR AB - Introduction: Infections related to central venous catheters (CVC) are complications with a high prevalence and possible serious consequences. Administration of total parenteral nutrition (TPN) is a risk factor, although the information available for these patients and conventional inpatient units is scarce. Objective: To determine the rate of catheter-related bacteremia (CRB) in patients with TPN and to identify possible relationships with administration route or place of insertion, to determinate the current situation and identify possible preventive measures. Method: Prospective-observational study of 13 months. All adult patients who received TPN were included. Infection rate used was the CRB per 1,000 days of CVC. Results: 176 CVC were registered in 159 patients. In 47% of CVC, vein access was jugular vein, despite being a location of greatest risk of infection. In critically ill patients, which followed a zero bacteremia project, there was no cases of infection. In other patients, bacteremia rate was 13.10 per 1,000 days of CVC. The average time elapsed between catheter insertion and infection was 11 days (range: 4-22) and the most frequent species were S. epidermidis (38%) and S. hominis (19%). Discussion: In our environment there is a high rate of BRC in non-critical patients, with a high proportion of CVC in locations with higher risk of infection, despite not having found in the sample a higher rate of infection depending on the access route. Place of insertion, operating room face ward, is related to a lower rate of BRC. Measures to standardize clinical practice may reduce its incidence. The zero bacteremia project is confirmed as a highly effective method. AU - Seisdedos Elcuaz, R. AU - Conde García, M. C. AU - Castellanos Monedero, J. J. AU - García-Manzanares Vázquez de Agredos, A. AU - Valenzuela Gámez, J. C. AU - Fraga Fuentes, M. D. DO - 10.3305/nh.2012.27.3.5729 IS - 3 KW - Bacteremia KW - Central venous catheter KW - Infection KW - Total parenteral nutrition PY - 2012 SP - 775 EP - 780 TI - Infecciones relacionadas con el catéter venoso central en pacientes con nutrición parenteral total T2 - Nutricion Hospitalaria VL - 27 ER - TY - JOUR AB - Las infecciones asociadas al cuidado de la salud representan un problema de salud pública y son un indicador de la calidad en prestación y gestión en salud. Es por esto que ha sido necesaria la creación de programas de vigilancia y control epidemiológico, y la adaptación e implementación de guías para su prevención. Estas estrategias mejoran la seguridad del paciente y deben ser una prioridad para las instituciones. En este contexto, la infección asociada a catéter es la más común de las infecciones asociadas al cuidado de la salud, principalmente en la población pediátrica, siendo los neonatos los más susceptibles a causa de la inmadurez de sus barreras primarias y sistema inmunológico, y a la alta frecuencia de procedimientos invasivos como los accesos vasculares para la administración de medicamentos o la nutrición parenteral. Actualmente existen múltiples medidas para prevenir dichas infecciones en pediatría y la tendencia es crear estrategias bien estructuradas para facilitar su aplicación. La higiene de manos continúa siendo un pilar fundamental dentro de todos los protocolos para disminuir las tasas de infección asociadas al cuidado de la salud; sin embargo, se requiere de nuevas estrategias para la prevención de las mismas, como el uso de la clorhexidina como antiséptico tópico previo a la inserción de dispositivos intravasculares y el aseo rutinario en pacientes con catéteres centrales, lo cual es el objeto de revisión de este manuscrito. AU - Castaño-Jaramillo, Lina M. AU - Henao-Ochoa, Carolina AU - Osorio-Vásquez, Ana C. DO - 10.36384/01232576.122 IS - 5-6 KW - clorhexidina KW - infecciones relacionadas con catéteres KW - infección hospitalaria KW - recién PY - 2015 SP - 243 EP - 254 TI - Uso de clorhexidina y su papel preventivo en las infecciones del torrente sanguíneo asociadas a catéteres en los recién nacidos: revisión de tema T2 - Medicina y Laboratorio VL - 21 ER - TY - GEN AB - Background: The use of central venous catheters impregnated with either minocycline and rifampin or chlorhexidine and silver sulfadiazine reduces the rates of catheter colonization and catheter-related bloodstream infection as compared with the use of unimpregnated catheters. We compared the rates of catheter colonization and catheter-related bloodstream infection associated with these two kinds of antiinfective catheters. Methods: We conducted a prospective, randomized clinical trial in 12 university-affiliated hospitals. High-risk adult patients in whom central venous catheters were expected to remain in place for three or more days were randomly assigned to undergo insertion of polyurethane, triple-lumen catheters impregnated with either minocycline and rifampin (on both the luminal and external surfaces) or chlorhexidine and silver sulfadiazine (on only the external surface). After their removal, the tips and subcutaneous segments of the catheters were cultured by both the roll-plate and the sonication methods. Peripheral-blood cultures were obtained if clinically indicated. Results: Of 865 catheters inserted, 738 (85 percent) produced culture results that could be evaluated. The clinical characteristics of the patients and the risk factors for infection were similar in the two groups. Catheters impregnated with minocycline and rifampin were 1/3 as likely to be colonized as catheters impregnated with chlorhexidine and silver sulfadiazine (28 of 356 catheters [7.9 percent] vs. 87 of 382 [22.8 percent] , P < 0.001), and catheter-related bloodstream infection was 1/12 as likely in catheters impregnated with minocycline and rifampin (1 of 356 [0.3 percent], vs. 13 of 382 [3.4 percent] for those impregnated with chlorhexidine and silver sulfadiazine; P < 0.002). Conclusions: The use of central venous catheters impregnated with minocycline and rifampin is associated with a lower rate of infection than the use of catheters impregnated with chlorhexidine and silver sulfadiazine. AU - Darouiche, Rabih O. AU - Raad, Issam I. AU - Heard, Stephen O. AU - Thornby, John I. AU - Wenker, Olivier C. AU - Gabrielli, Andrea AU - Berg, Johannes AU - Khardori, Nancy AU - Hanna, Hend AU - Hachem, Ray AU - Harris, Richard L. AU - Mayhall, Glen DO - 10.1056/nejm199901073400101 IS - 1 PY - 1999 SP - 1 EP - 8 TI - A Comparison of Two Antimicrobial-Impregnated Central Venous Catheters T2 - New England Journal of Medicine VL - 340 ER - TY - GEN AB - Hipótesis de trabajo: -La cateterización de una vía venosa central es una técnica invasiva, no exenta de complicaciones. -La cateterización venosa central presenta distintas tasas de complicaciones en dependencia de la localización anatómica seleccionada para su abordaje. -Existen diversos factores anatómicos, clínicos o del propio paciente que pueden influir en la aparición de estas complicaciones. Objetivos: -Estudiar la relación entre la vía de abordaje y las complicaciones inmediatas y diferidas derivadas de la técnica. -Valorar la existencia de factores de riesgo que aumenten las tasas de complicaciones agudas y diferidas tales como abordaje seleccionado, número de punciones, personal que realiza la técnica, anatomía desfavorable, y extrema urgencia. Métodos: Se recogieron 316 procedimientos consecutivos, en la UCI del H. San Jorge de Huesca, entre Junio de 2013 y Abril de 2015. Se realizó un estudio comparativo, prospectivo de las distintas vías de abordaje venoso central (Yugular, Femoral, Subclavia, Axilar) con la aparición de complicaciones inmediatas, tales como punción arterial, neumotórax, no canalización, malposición catéter, sangrado pericateter y mixtas, y complicaciones diferidas, como complicaciones mecánicas ( trombosis venosa profunda, hematoma, rotura de catéter, arrancamiento, sangrado, obstrucción), infecciosas (bacteriemia y fungemia) y complicaciones menores (flebitis, infección del punto de punción y colonización del catéter). Para el estudio de diferencias significativas respecto a Factor de Riesgo se utilizó el test de Chi cuadrado. Resultados: Se obtuvo una media de 1,9 punciones por vía, un 22% de los casos precisó 3 o más punciones para su canulación. En el 53% de los casos se realizó una RX de control, en un 11% de los casos se utilizó guía ecográfica. -Respecto a complicaciones agudas, tanto la localización de la vía, como el número de punciones, y la anatomía desfavorable son aspectos que están relacionados con la existencia de diferencias significativas. -Respecto a complicaciones diferidas, únicamente la localización de la vía repercute en la existencia de diferencias significativas, aunque sólo para el caso de complicaciones de tipo mecánico. -La localización de la vía influye de manera significativa tanto en las complicaciones agudas (neumotórax), como diferidas (mecánicas), no así el personal que realiza la técnica, ni los posibles casos de extrema urgencia. El número de punciones y anatomía desfavorable influyen en las complicaciones agudas, tanto en la tasa global como en el de no canalización. AU - Cambra Fierro, R.P. PY - 2016 TI - Canulación de vías centrales: estudio de las complicaciones inmediatas y diferidas tras la colocación de los catéteres venosos centrales y su relación con la vía de abordaje ER - TY - GEN AB - La importancia de la adecuada y acertada colocación de una vía central en una emergencia puede ser la diferencia entre salvar o no la vida de las personas que acuden a los centros de emergencias de los hospitales de referencia en las grandes ciudades. La forma tradicional con la que se ha venido colocando las mismas durante las últimas dos o tres décadas en los servicios de emergencia y como se ha enseñado a los médicos en formación (Posgradista) ha sido la colocación de estas vías con referencia anatómica, que según Xu y colaboradores en su estudio realizado en el año 2015, menciona que el éxito de una adecuada colocación esta alrededor del 70%, es decir, el 30% necesita una recolocación o presentará una complicación que puede ir desde muy leve a muy grave, incluso compromete la vida del paciente, al utilizar esta técnica puede no tener éxito en un 35%, presentando una tasa de complicaciones de hasta 19%, sin contar el 9% de personas que presentan alguna anomalía anatómica que puede dificultar e incluso impedir su colocación. Durante e incluso después del procedimiento pueden presentarse complicaciones de diversa gravedad poniendo en riesgo la vida del paciente, se reconoce que estos procedimientos pueden ser peligroso o incluso mortales en algunas casos, por el tipo de complicaciones, especialmente las de tipo mecánicos, cómo puede ser taponamiento cardíaco, hematoma cervical masivo, hemotórax y la punción de vía aérea que provocarían riesgo vital inminente al paciente (17), la FDA (Food and Drug Administration) describe un rango de complicaciones 5-20% relacionados a la punción durante este procedimiento, además de los riesgos que se podrían presentar por características propias del paciente como índices de masa corporal >30 o < 20 Kg/m2 (obesidad y caquexia), cuello corto, enfermedades vasculares, cirugías previas, radioterapia en las zonas elegidas para la cateterización, historia de cateterizaciones previas, coagulopatías, factores ambientales e incluso la posición adoptada para la punción (1,10). Estos datos internacionales no han sido establecidos en nuestro país, por lo que mi estudio ofreció una visión de estos porcentajes en dos hospitales de la Ciudad de Quito. Además nos permitió conocer el número y el tipo de complicaciones existentes. AU - Molina Amores, María Fernanda PY - 2016 SP - 96 EP - 96 TI - Analisis comparativo de las complicaciones de las vias centrales ecodirgidas vs las dirigidas con referentes anatomicos en dos hospitales de la ciudad de quito en el periodo: junio 2014 a hjunio 2015 UR - http://repositorio.puce.edu.ec/handle/22000/10477 ER - TY - JOUR AB - ABSTRACT: This study aims to determine the effect of job design and management information technologi on service quality State Senior High School in Nort Jakarta. The method used ini this research is survey method with path analysis techniques. This study used a population of teachers State Senior High School in Nort Jakarta much as 150 teachers. Sampling techniques in this study is proportional random sampling methode. Based on the results of the study can be summarized as follows: Firstly, there is the effect of job design on service quality; Secondly, there is the effect of management information technology on service quality; Third, there is the effect of job design on management information technology. AU - Ipa, Pengetahuan AU - Di, Siswa PY - 2017 TI - Predictores de la veociad de progresion ER - TY - GEN AB - De la bataille de Poitiers aux croisades, des échanges intellectuels du Moyen Age à l'orientalisme, de la colonisation à la guerre d'Algérie jusqu'aux débats actuels sur l'immigration, plus de soixante-dix spécialistes, historiens ou grands témoins retracent treize siècles d'une histoire politique, sociale et culturelle tumultueuse et captivante. " C'est l'histoire culturelle qui domine ici, écrit Jacques Le Goff dans sa préface, et plus largement une histoire de l'imaginaire qui nous livre les fluctuations de l'image de l'Autre... Il s'agit de faire passer le musulman de la situation d'Autre à celle de concitoyen à part entière. Il reste sans doute un long chemin à parcourir, et l'éclairage de l'histoire depuis le Moyen Age y est nécessaire. " Un ouvrage de référence unique, passionnant et richement illustré. AU - Castaño Tobon, Hector fabio IS - December PY - 2006 SP - 1 EP - 6 TI - Prevalencia y factores de riesgo asociados a complicaciones mecánicas inmediatas de cateterismo venoso central en pacientes mayores de 18 años del hospital universitario hernando moncaleano perdomo de neiva entre junio y noviembre del 2005 VL - 1999 ER - TY - BOOK AB - … Akses terbuka (open access), memberi keleluasaan kepada siapapun yang membutuhkan informasi khususnya melalui sumber daya … Dalam akses terbuka (open access), informasi dengan teknologi digital ada kebebasan untuk mengakses bagi siapa saja yang membutuhkan … AU - Perez-Lescure, Javier PY - 1384 SP - 121 EP - 121 TI - Manual de tecnicas y procedimientos en urgencias de pediatria para enfermeria y medicina ER - TY - GEN AU - Calvo Rivas, Leticia PY - 2015 SP - 132 EP - 132 TI - Intervencion de enfemreria en la prevencion y tratamiento de complicacions vsculares en intervencioniso cardiologico percutaneo estructural ER - TY - JOUR AU - Francés, Ana Tauste AU - Ronda-pérez, Elena AU - Seguí, Mar IS - 2 KW - astenopía KW - exposición profesional KW - lentes de contacto KW - putador KW - salud laboral KW - síndromes de ojo seco KW - terminales de com- PY - 2014 SP - 203 EP - 215 TI - Alteracione oculares y visuales en personas que trabajan con ordenador y son usuarias de lentes de contacto: una revision Biblografica T2 - Rev Esp Salud Pública VL - 88 ER - TY - JOUR AB - Introduction: Visual problems caused by computer use are nowadays one of the most common conditions among workers. This paper summarizes the scientific evidence on Eye Fatigue Syndrome (EFS) and its relationship to work environment, risk factors, especially sensitive population and preventive aspects. AU - Prado Montes, Ana AU - Morales Caballero, Álvaro AU - Molle Cassia, Jossias Navor IS - 249 KW - Asthenopia KW - Computer Vision Syndrome KW - Dry Eye Syndrome KW - Eye Fatigue KW - Eyestrain KW - Visual Fatigue KW - Workers PY - 2017 SP - 345 EP - 361 TI - Síndrome de Fatiga ocular y su relación con el medio laboral T2 - Med. segur. trab VL - 63 ER - TY - GEN AB - Seorang tenaga kerja yang baik harus mempunyai kemampuan, keterampilan, pengetahuan, sikap dan etika agar menghasilkan produktivitas kerja yang tinggi. Produktivitas kerja yang tinggi, mudah dicapai apabila didukung oleh tenaga kerja yang sering termotivasi oleh pimpinan dalam melaksanakan pekerjaannya. Produktivitas kerja yang tinggi sangat diinginkan oleh banyak instansi, salah satunya Rumah Sakit. Tujuan penelitian ini untuk mengetahui hubungan motivasi kerja dengan produktivitas kerja petugas pendaftaran di RSU ‘Aisyiyah Ponorogo. Desain penelitian ini adalah korelasional dengan pendekatan cross sectional. Populasi penelitian ini adalah semua petugas pendaftaran di RSU ‘Aisyiyah Ponorogo yang berjumlah 20 (dua puluh) petugas. Teknik sampling yang digunakan adalah sampling jenuh. Analisis data yang digunakan adalah analisis spearman rank. Dari hasil pengolahan data menggunakan uji spearman rank program SPSS 16.0. Ada hubungan motivasi kerja dengan produktivitas kerja petugas pendaftaran di RSU ‘Aisyiyah Ponorogo. Hasil dari analisa menunjukkan ρ value lebih kecil dari 0,05 (sig. ρ 0,023 < 0,05) dengan tingkat koefisien korelasi sedang yaitu sebesar 0,504. Kata AU - Peralta Ruiz, Keytlin AU - Peralta Zapata, Jesus IS - 4 PY - 2017 SP - 130 EP - 130 TI - Salud Visual T2 - Occupational Medicine VL - 53 ER - TY - JOUR AB - Resumen La alergia ocular consiste en un grupo de enfermedades ca-racterizadas por inflamación de la conjuntiva ocular, dentro de las que podemos encontrar a la conjuntivitis alérgica es-tacional (CAE) o perenne (CAP), la queratoconjuntivitis vernal, la queratoconjuntivitis atópica y la blefaroconjuntivitis de contacto. Aqueja aproximadamente al 10% de la población mundial, y los más afectados son pacientes con otras patolo-gías alérgicas. El diagnóstico es clínico y se integra mediante los síntomas y hallazgos encontrados durante la exploración física oftalmológica presentes en el sujeto al momento de la visita. Los principales objetivos del tratamiento en la conjuntivitis alérgica son minimizar y controlar los signos y síntomas de la enfermedad, incluyendo la reducción del prurito, de la hiperemia y del edema de la conjuntiva y párpados, así como mejorar la calidad de vida del paciente. El tratamiento incluye medidas no farmacológicas, como evitar estímulos irritantes, el uso de lágrimas artificiales, la aplicación de compresas frías y medicamentos como vasoconstrictores, antihistamínicos, estabilizadores de mastocitos, agentes de acción dual, este-roides y fármacos inmunomoduladores, así como inmuno-terapia alérgeno específica. Los cambios desencadenados por la inflamación de la con-juntiva, producen daño corneal mecánico, y en los casos graves y crónicos de la enfermedad, el daño corneal puede resultar en la disminución de la agudeza visual, lo cual disminuye la calidad de vida del paciente. Palabras clave: Alergia ocular, conjuntivitis alérgica estacional (CAE), conjuntivitis alérgica perenne (CAP), queratoconjuntivitis vernal, queratoconjuntivitis atópica, blefaroconjuntivitis. Ocular allergy Abstract Ocular allergy is a group of diseases characterized by inflammation of the ocular conjunctiva and include seasonal allergic conjunctivitis, perennial allergic conjunctivitis, vernal kerato-conjunctivitis, atopic keratoconjunctivitis and contact bleph-aroconjunctivitis. It affects approximately 10% of the world population primarily in patients with other allergic diseases. The diagnosis is clinical; it is integrated through the symptoms and the findings discovered during the physical examination. The main goals of the treatment in allergic conjunctivitis are to minimize and control the signs and symptoms of the dis AU - Navarrete-Rodriguez, Elsy AU - Sierra-Monge, Juan Jose Luis AU - Ureña-Ortiz, Roberto DO - 10.1016/s0716-8640(10)70612-x IS - 6 KW - alergia ocular KW - blefaroconjuntivitis KW - cae KW - cap KW - conjuntivitis alérgica estacional KW - conjuntivitis alérgica perenne KW - queratoconjuntivitis KW - queratoconjuntivitis atópica KW - vernal PY - 2010 SP - 875 EP - 882 TI - Alergia ocular T2 - Revista Médica Clínica Las Condes VL - 21 ER - TY - GEN AB - 1. Alwafi Ridho Subarkah. No Title空間像再生型立体映像の 研究動向. In: Nhk技研. 2018. p. 10–7. AU - Hurtado Giraldo, Laura Karina IS - 2 KW - fakultas ilmu sosial dan KW - halal tourism KW - internasional KW - korespondensi KW - local economy KW - mahasiswa program magister hubungan KW - public diplomacy KW - west nusa tenggara PY - 2018 SN - 9781450349185 SP - 10 EP - 17 TI - Estudio de viabilidad comercial para la distribucion de monturas oftalmicas en Bogota VL - 151 ER - TY - JOUR AU - Gomez Morales, Jesus AU - Llopiz Morales, Mayra AU - Luaces martinez, Angela AU - Blanco Cabrera, Yudith AU - Viera Rosares, Mercy AU - Solis Cartas, Urbano IS - 2 KW - artritis reumatoide KW - comportamiento de las manifestaciones KW - manifestaciones oculares KW - oftalmológicas en pacientes con PY - 2015 SP - 139 EP - 144 TI - Behavior of the ophthalmologic manifestations in patient with rheumatoid arthritis T2 - Revista Cubana de Reumatología VL - 17 ER - TY - JOUR AB - OBJECTIVES Determining Demodex folliculorum infection prevalence in patients attending general ophthalmological consultation and such infection's association with blepharitis. METHODS This was a descriptive study of such prevalence. 128 subjects who attended the Virgilio Galvis Eye Centre were randomly selected and the presence of D. folliculorum was determined in 4 eyelashes taken from each of them. RESULTS D. folliculorum infection prevalence was 42.1% (n=54); blepharitis was diagnosed in 38.3% of the patients (n=49) and 63.2% of them (n=31) were positive for D. folliculorum. Only 29.2% of the individuals in the group without blepharitis (n=79) had mites (n=23) (p=0.0003). A higher number of parasites was found in patients with blepharitis (12.7 parasitic load index cf 5.1; p=0.0001); 25% (n=32) of the participants had scaling in the form of cylinders and 96.9% of these had the mites (n=31), whereas the mite was only present in 24% (n=23) of subjects who had no cylinder-type scaling (n=96). CONCLUSIONS Demodex folliculorum is a parasite found in people without ocular lesions; however, it is more frequent and has a higher parasite burden in patients with blepharitis. Our results suggested the need for investigating the presence of D. folliculorum in all patients suffering from blepharitis, especially in cases where cylinder-type scaling has been observed in their eyelashes. AU - Galvis-Ramírez, Virgilio AU - Tello-Hernández, Alejandro AU - Álvarez-Osorio, Leonardo AU - Rey-Serrano, Juan J DO - 10.1590/S0124-00642011000600011 IS - 6 PY - 2011 SP - 990 EP - 7 TI - Prevalencia de infección por Demodex folliculorum en pacientes que acuden a consulta general de oftalmología T2 - Revista de salud publica (Bogota, Colombia) UR - http://www.ncbi.nlm.nih.gov/pubmed/22635000 VL - 13 ER - TY - JOUR AB - Degenerative myopia is one of the main causes of visual impairment. This is related to disorders in the posterior pole, affecting the neurosensorial retina, the retinal pigmented epithelium and the inner choroidal layers. The slow and progressive course of this condition demands comprehensive assessment and long follow-up, which is a challenging task for ophthalmologists. A review of the articles indexed in PubMed regarding the clinical characteristics of the fundus in patients with degenerative myopia was made to describe the main disorders of the posterior pole of the eyeball. Posterior staphyloma was found among the typical lesions of high myopia, associated with patchy or diffuse chorioretinal atrophy, lacker cracks, choroidal neovascular membranes and macular hemorrhages secondary to them or stemmed from choroidal neovascular membranes. More accurate diagnosis of foveoschisis, macular holes, and more recently dome-shaped macula has been achieved with optical coherence tomography. The degenerative changes of posterior pole seem to be associated each other, but pathogenesis of myopic retinopathy has not been clearly stated, despite the recent technological advances. La miop{í}a degenerativa constituye una de las causas fundamentales de p{é}rdida de la visi{ó}n. Esto est{á} relacionado con las alteraciones del polo posterior, que afectan la retina neurosensorial, el epitelio pigmentario de la retina y las capas m{á}s internas de la coroides. Su curso lento y progresivo demanda una exploraci{ó}n integral, con seguimiento en el tiempo y constituye un reto para el oftalm{ó}logo. Se realiz{ó} una revisi{ó}n de art{í}culos publicados e indexados en la base de datos de PubMed que se refirieran a las caracter{í}sticas cl{í}nicas del fondo de ojo en pacientes con miop{í}a degenerativa, para describir las principales alteraciones del polo posterior del globo ocular en esta entidad. Se encontr{ó} entre las lesiones t{í}picas de la alta miop{í}a, al estafiloma posterior como un signo patognom{ó}nico de la enfermedad, asociado a la atrofia coriorretiniana en parches o difusa, as{í} como las estr{í}as de laca y las hemorragias maculares secundarias a ellas o provenientes de membranas neovasculares coroideas. La tomograf{í}a de coherencia {ó}ptica ha permitido un diagn{ó}stico m{á}s preciso de otras lesiones maculares como la foveosquisis, el agujero macular y, m{á}s recientemente, la m{á}cula en domo. Los cambios degenerativos del polo posterior parecen guardar relaci{ó}n unos con otros pero la patogenia no ha sido bien esclarecida a pesar de los avances tecnol{ó}gicos. AU - Lapido Polanco, Suzel Ivón AU - González Díaz, Rafael Ernesto AU - Rodríguez Rodríguez, Violeta AU - González Arias, Yorlandis AU - Baldoquín Rodríguez, Waldemar AU - López González, Madelaine IS - 2 KW - Ophthalmology KW - RE1-994 KW - choroidal neovascularization KW - degenerative myopia KW - estafiloma posterior KW - foveoschisis KW - foveosquisis KW - miopía degenerativa KW - neovascularización coroidea KW - posterior staphyloma PY - 2012 SP - 288 EP - 302 TI - Alteraciones del polo posterior en la miopía degenerativa T2 - Revista Cubana de Oftalmología VL - 25 ER - TY - JOUR AB - Purpose: Our goal was to analyze the prevalence of depression and anxiety among patients with glaucoma and to identify risk factors related to these disorders. Methods: A cross-sectional study was carried out between August 2016 and August 2017 at the Hospital das Clínicas of Universidade Estadual de Campinas and at the Hospital Oftalmológico de Brasília to evaluate the prevalence of depressive and anxiety disorders among patients diagnosed with glaucoma. All patients underwent a complete ophthalmologic examination with standard automated perimetry to confirm the diagnosis of glaucoma. All participants were asked to complete the Hospital Anxiety and Depression Scale questionnaire. Results: One hundred and twenty-nine patients were included in the study. Seventy-four were men (57.36%) and 55 (42.64%) were women. The mean age of the patients was 70.14 ± 15.8 years. Ninety participants were white (69.77%) and 38 (29.46%) were black. The study demonstrated a prevalence of depression and/or anxiety at 10.08%. Logistic regression revealed that women were at higher risk for anxiety and/or depression (OR: 5.25, p=0.015) and patients with a larger number of co-morbidities also were at higher risk for anxiety and/or depressive disorders (OR: 2.82, p=0.038). Conclusion: A significant proportion of patients with glaucoma present with depression and/or anxiety. Females and patients with co-morbidities are at greater risk for these disorders. AU - Abe, Ricardo Yuji AU - Silva, Ludmila Nascimento P. AU - Silva, Daniela Mendes AU - Vasconcellos, José Paulo Cabral AU - Costa, Vital Paulino DO - 10.5935/0004-2749.20210006 IS - 1 KW - Anxiety/epidemiology KW - Cross-sectional studies KW - Depression/epidemiology KW - Glaucoma PY - 2021 SP - 31 EP - 36 TI - Prevalence of depressive and anxiety disorders in patients with glaucoma: a cross-sectional study T2 - Arquivos Brasileiros de Oftalmologia VL - 84 ER - TY - JOUR AU - Menezas, Laissa de Moraes AU - Morais, Nilson Nero de Araujo DO - 10.5935/0034-7280.20 IS - 1 KW - diabetes mellitus KW - fundoscopy KW - hypertension KW - retinography KW - visual acuity PY - 2020 SN - 0000000177221 SP - 28 EP - 32 TI - Fundoscopy findings of diabetic and/or hipertensive patients T2 - Rev Bras Oftalmol VL - 79 ER - TY - JOUR AU - Cetinkaya, Servet AU - Oncel Acir, Nursen AU - Cetinkaya, Yasemin Fatima AU - Dadaci, Zeynep AU - Yener, Halil Ibrahim AU - Saglam, Faik IS - 5 KW - adverse effects KW - cataract KW - myopia KW - phacoemulsification KW - retinal detachment PY - 2015 SP - 286 EP - 9 TI - Phacoemulsificatıon in eyes wıth cataract and high myopia T2 - Arq Bras Oftalmol VL - 78 ER - TY - JOUR AB - RESUMEN Objetivo: describir las características clínicas y epidemiológicas del queratocono en el Instituto Cubano de Oftalmología "Ramón Pando Ferrer". Métodos: se realizó un estudio descriptivo en 72 pacientes (128 ojos) con queratocono, atendidos entre enero y diciembre de 2012, para identificar las enfermedades generales y oculares, tiempo de uso de lentes de contacto, manifestaciones clínicas, tipo de astigmatismo, poder queratométrico, espesor de la córnea central, topografía y microscopia confocal. Resultados: el 50 % de los pacientes presentó disminución lenta y progresiva de la visión, con significativa ausencia de enfermedades generales. Fueron significativos (p< 0,05) el uso prolongado de lentes de contacto (67 %), la mejoría de la agudeza visual con corrección y el astigmatismo miópico compuesto (85,2 %). Predominó la disminución del espesor de la córnea central (493,2 µm). Los intervalos de poder queratométrico de la córnea central fueron igualmente representados (p= 0,211). Por topografía predominó el astigmatismo irregular (99,2 %) y el cono central (87,5 %). La microscopia confocal reflejó alteraciones en casi todas las capas de la córnea. Conclusiones: la queratoconjuntivitis alérgica es la enfermedad ocular más frecuentemente asociada al queratocono. Posee un patrón topográfico de astigmatismo irregular con cono central y agudeza visual con corrección, con lentes de contacto de 0,6. La microscopia confocal constituye una herramienta valiosa en el diagnóstico del queratocono. Revista Cubana de Oftalmología 2014;27(4):598-609 http://scielo.sld.cu 599 Palabras clave: queratocono, caracterización clínica, microscopia confocal. ABSTRACT Objective: to describe the clinical and epidemiological characteristics of keratoconus treated at "Ramón Pando Ferrer" Cuban Institute of Ophthalmology. Methods: a descriptive study was conducted in 72 patients (128 eyes) with keratoconus, from January to December 2012, to identify general and ocular diseases, length of time wearing the contact lenses, clinical features, type of astigmatism, keratometric power and central corneal thickness, topography and confocal microscopy. Results: in the group, 50 % had slow gradual decrease of vision, with no significant medical illnesses. Wearing contact lenses for a long time (67 %), the improvement of visual acuity with correction and myopic compound astigmatism (85,2 %) were significant (p< 0,05). Thinning of the central cornea (493,2 microns) predominated. Keratometric power intervals of the central cornea were equally represented (p= 0,211). The irregular astigmatism (99,2 %) and the central cone (87,5 %) prevailed in terms of topography. Confocal microscopy changes in almost all the corneal layers. Conclusions: Allergic keratoconjunctivitis is the most associated eye disease. It has topographic pattern of irregular astigmatism with central cone and corrected visual acuity, with 0,6 contact lenses. Confocal microscopy is a valuable tool in the diagnosis of keratoconus. AU - Pérez Parra, Zaadia AU - Ulloa Oliva, Solaimi AU - Escalona Leyva, Elizabeth AU - Castillo Pérez, Alexeide AU - Márquez Villana, Susana IS - 4 PY - 2014 SP - 598 EP - 609 TI - Caracterización clínica y epidemiológica del queratocono Clinical and epidemiological characterization of keratoconus T2 - Revista Cubana de Oftalmología UR - http://www.medigraphic.com/pdfs/revcuboft/rco-2014/rco144j.pdf VL - 27 ER - TY - JOUR AU - Ochoa, Madelyn Jareño IS - 1 PY - 2020 SP - 1 EP - 11 TI - Tomographic results after the treatment of queratocono with corneal crosslinking Madelyn T2 - Revista Cubana de Oftalmología VL - 33 ER - TY - JOUR AB - RESUMEN Los científicos han estado interesados en el estudio de las secreciones de las glándulas de Meibomio desde hace muchos años. Enfermedades asociadas, como los cánceres y la blefaritis posterior, se han observado en la literatura médica, desde la primera parte del siglo XX. Sin embargo, el término "disfunción de las glándulas de Meibomio" fue introducida por Korb y Henríquez en 1980. No existía una definición establecida publicada en la literatura hasta que más de 50 expertos internacionales participaron en un taller, que tuvo lugar durante un período de dos años, donde se llegó a definir como una anormalidad crónica y difusa de estas glándulas, comúnmente caracterizada por la obstrucción del conducto terminal y cambios cualitativos/cuantitativos en la secreción de esta. Esto puede resultar en la alteración de la película lagrimal, síntomas de irritación ocular, inflamación clínicamente aparente y enfermedad de la superficie ocular. Es en el mismo Taller Internacional, donde se decide clasificar de acuerdo con los cambios anatómicos, fisiopatológicos, o la gravedad de la enfermedad, donde la forma obstructiva fue la más generalizada. Constituye una afección frecuente con disminución de la calidad de vida y perjuicios potencialmente graves para el bienestar humano. Palabras clave: glándulas de Meibomio, disfunción, superficie ocular. AU - Taimí, Dra AU - Díaz, Cárdenas AU - López, Hernández AU - Guerra Almaguer, Michel AU - Dunia, Dra AU - Izquierdo, Cruz AU - Iramis, Dra AU - Hernández, Miranda AU - Montero Díaz, Eric IS - 2 KW - disfunción KW - glándulas de meibomio KW - superficie ocular PY - 2014 SP - 264 EP - 271 TI - Conceptos actuales en la disfunción de las glándulas de Meibomio Current concepts about the meibomian gland dysfunction T2 - Revista Cubana de Oftalmología UR - http://scielo.sld.cu VL - 27 ER - TY - JOUR AB - BACKGROUND: Infestation by Demodex spp. in the palpebral edge follicles in humans is common. However, these mites are not routinely diagnosed in patients with or without ocular pathologies in Chile and their relevance is unclear. One of the eye diseases most related to infestation by Demodex spp. is blepharitis, a chronic inflammation of the eyelid margin with intermittent exacerbations, which is very common in ophthalmic practice. Its management is prolonged treatment, which is often ineffective, leading to relapses and frustration of patient and treating physician. Blepharitis can be typed by its etiology into various types, one of them is caused by Demodex folliculorum and another species, D. brevis. OBJECTIVE: The overall objective was to detect the presence and estimate the rate of infestation of Demodex spp. in healthy subjects and in patients with ocular pathology such as blepharitis, bacterial conjunctivitis, chalazion, and stye. PATIENTS AND METHODS: Samples of tabs from both lower eyelids of ophthalmologically healthy patients (23) and patients with ocular pathologies (9) were mounted in immersion oil as described in literature, then visualized with a 10x objective and confirmed with 40x objective. RESULTS: Detection rates of eggs, nymphs or adults of Demodex spp. in patients with and without ophthalmological problems were above and below 0.5 mites per tab, respectively. D.folliculorum was the species most frequently found. DISCUSSION: The results are consistent with the international literature on both the rate of infestation as the predominant species. CONCLUSION: This paper is the first study in Chile on this subject and represents a significant contribution to ophthalmic clinical diagnosis and treatment of patients with this disease. AU - Rivera Fuentes, Nancy AU - Molina, Priscila AU - Torres, Andrea DO - 10.4067/S0716-10182013000500005 IS - 5 KW - Blepharitis KW - Demodex spp. KW - Infestation index PY - 2013 SP - 494 EP - 501 TI - Determinación de índice de infestación por Demodex spp, en pacientes con blefaritis crónica y en pacientes sin otra patología ocular T2 - Revista chilena de infectología VL - 30 ER - TY - JOUR AB - Objective. To determine the prevalence of dry eye symptoms (DES) and associated risk factors among adults in Tlaxcala, Mexico. Materials and methods. A cross-sectional population-based study that included 1 508 individuals aged ≥50 years who answered the Dry Eye Questionnaire (DEQ- 5), with a score ranging between 0 and 22; the following categories were defined: no DES ( < 6); mild-moderate DES (6 to 11) and severe DES (≥12). Results. The prevalence of DES was 41.1% (95%CI 38.6-43.6), and was higher in women (OR=2.26, 95%IC 1.70-3.00), in individuals with smoking index of < 10 (OR=1.40, 95%CI 1.05-1.87) and ≥10 pack-years (OR=2.29, 95%CI 1.44-3.63), compared to never-smokers, subjects with history of ever consuming alcohol (OR=1.31, 95%CI 1.02-1.70), and those receiving antihypertensive treatment (OR=1.29, 95%CI 1.00-1.65). Conclusion. Dry eye symptoms were highly prevalent in the study population and were associated with sex, smoking, alcohol consumption, and antihypertensive medications. AU - Graue-Hernández, Enrique O. AU - Serna-Ojeda, Juan Carlos AU - Estrada-Reyes, Carlos AU - Navas, Alejandro AU - Arrieta-Camacho, Jesús AU - Jiménez-Corona, Aida DO - 10.21149/9024 IS - 5 KW - Cuestionario de ojo seco KW - Dry Eye Questionnaire 5 KW - Dry eye symptoms KW - Prevalence KW - Prevalencia KW - Síntomas de ojo seco PY - 2018 SP - 520 EP - 527 TI - Dry eye symptoms and associated risk factors among adults aged 50 or more years in Central Mexico T2 - Salud Publica de Mexico VL - 60 ER - TY - JOUR AB - Background: Allergic conjunctivitis is caused by an IgE-mediated mechanism or immediate hypersensitivity due to allergen direct contact on the conjunctival surface of sensitized patients, which elicits mastocyte activation and inflammatory mediators' release. Up to 47% of patients with allergic conjunctivitis can develop sensitization to perennial allergens; more than 24% of patients can experience sensitization to multiple allergens. Objective: To estimate positive skin reactivity to allergens in patients diagnosed with allergic conjunctivitis in the allergology outpatient clinic of Centro de Especialistas Santo Domingo, in Cartagena, Colombia, during 2017. Method: Cross-sectional study of 92 patients aged between 3 and 74 years, included by convenience sampling. Results: 70.65% had positive skin prick tests to at least one allergen. Most common allergens with positive skin reactivity were house dust mites (65.2%), animal epithelia (15.2%), insects (15.2%) and food (14.1%). Allergic rhinitis (51%), allergic asthma (23%) and atopic dermatitis (10%) were the most commonly associated allergic pathologies. Conclusions: Positive skin reactivity to the studied allergens was significantly higher in patients with allergic conjunctivitis and other associated conditions. AU - Miranda-Machado, Pablo Andrés AU - De La Cruz-Hoyos Sánchez, Bautista DO - 10.29262/ram.v65i3.351 IS - 3 KW - Allergens KW - Allergic conjunctivitis KW - Skin prick tests PY - 2018 SP - 128 EP - 136 TI - Skin reactivity in allergic conjunctivitis T2 - Revista Alergia Mexico VL - 65 ER - TY - JOUR AB - ABSTRACT Infectious corneal ulcers are an ophtalmological emergency that threatens sight and eyes integrity, causing blindness in 1.5-2 million of people per year. The objective was to determinate epidemiological pattern, risk factors and treatment efficiency in patients with corneal ulcer in Fundacion Vision from 2015 to 2017. This was a prospective cohort study, 53 patients with infectious corneal ulcer were examined in Fundacion Vision from 2015 to 2017, and were followed for at least 4 months. Predominance of males (69.8%), aged 45-65 years (49.1%), married (54.7%), low socio-economic status (56.6%), farmers (26.4%), with a history of corneal trauma (69.8%) or contact lenses users (17%) were found. The etiological agent was bacterial in 49.1% and mycotic in 37.7%; the most accurate treatment for those of bacterial origin was fortified eye drops of Cefazolin+Gentamicin and Natamycin/Fluconazole in case of being fungal. The evolution was favorable in 90.9% and 80.0% of the bacterial and mycotic infections, respectively. High risk groups detected were male patients, farmers, low socio-economic status, with a history of corneal trauma or contact lenses user. On the other hand, the effectiveness of the treatment was greater than 80%, and the infections were mostly caused by bacterial pathogens. AU - Ku Lozano, Jenny AU - Samudio, Margarita AU - Penniecook-Sawyers, Jason A AU - Abente, Sonia AU - Duré, Carolina IS - 1 KW - Fundación Vision KW - Fundación Visión KW - Paraguay KW - corneal ulcer KW - factores de riesgo KW - keratitis KW - queratitis KW - risk factors KW - tratamiento KW - treatment KW - úlcera corneal PY - 2019 SP - 16 EP - 24 TI - Características clínico-epidemiológicas y evolución del tratamiento en pacientes con úlceras corneales TT - Clinical-epidemiological characteristics and treatment evolution of patients with corneal ulcer T2 - Memorias del Instituto de Investigaciones en Ciencias de la Salud UR - http://scielo.iics.una.py//scielo.php?script=sci_arttext&pid=S1812-95282019000100016&lang=pt%0Ahttp://scielo.iics.una.py/pdf/iics/v17n1/1812-9528-iics-17-01-16.pdf VL - 17 ER - TY - JOUR AB - Objectives: This study was performed to investigate whether different grades of diabetic retinopathy correlate with tear and ocular surface function in diabetic patients without subjective symptoms of dry eye. Methods: A total of 129 eyes of 72 patients without dry eye, assessed using McMonnies questionnaire were recruited to the study. The tear film and ocular surface were evaluated using the Schirmer test, tear film break-up time (BUT), fluorescein and lissamine green staining test, and conjunctival impression cytology. The results were analysed. Results: A normal Schirmer test and BUT was obtained in 51 and 67% of the eyes of diabetics patients, respectively. Fluorescein and lissamine green staining were negative in 81 and 95% of the eyes. The area and density of goblet cells was 580.46 ± 370 μm2 and 235.58 ± 109.03 goblets cell/mm2, respectively. Conclusions: Diabetic retinopathy patients without subjective symptoms of dry eye and normal Schirmer and BUT test showed pathological grades of squamous metaplasia. © 2010 Sociedad Española de Oftalmología. Published by Elsevier España, S.L. All rights reserved. AU - Figueroa-Ortiz, L. C. AU - Jiménez Rodríguez, E. AU - García-Ben, A. AU - García-Campos, J. DO - 10.1016/j.oftal.2010.12.010 IS - 4 KW - Conjunctival impression cytology KW - Diabetes mellitus KW - Ocular surface KW - Squamous metaplasia KW - Tear film test PY - 2011 SP - 107 EP - 112 TI - Estudio de la función lagrimal y la superficie conjuntival en pacientes diabéticos T2 - Archivos de la Sociedad Espanola de Oftalmologia VL - 86 ER - TY - JOUR AU - Quignón Santana, Sandra Saray AU - Alfonso Sánchez, Osbel AU - Marrero Delgado, Macmelsie AU - Delgado Figueredo, Rolando AU - Aroche Quintana, Marylin AU - Fernández Ferrer, Katiuska IS - 3 KW - diagnóstico KW - intestinal KW - parasitología KW - parasitosis KW - técnicas microbiológicas PY - 2012 SP - 151 EP - 162 TI - Influencia del tratamiento de la queratoconjuntivitis seca en la capacidad funcional y afectiva de los adultos mayores con artritis reumatoidea T2 - Revista Electrónica de las Ciencias Médicas en Cienfuegos VL - 10 ER - TY - GEN AU - OPS PY - 2015 TI - Los desafíos de la urbanización para la salud deben abordarse con políticas intersectoriales, afirman expertos T2 - Organización Panamericana de la salud UR - https://www.paho.org/es/noticias/3-12-2015-desafios-urbanizacion-para-salud-deben-abordarse-con-politicas-intersectoriales ER - TY - BOOK AU - Sociedad Española de Oftalmología., JS AU - García Lozano, I AU - Smaranda, A AU - Martínez Garchitorena, J IS - 5 PB - Sociedad Española de Oftalmología PY - 2005 SP - 289 EP - 296 TI - Archivos de la Sociedad Española de Oftalmología. T2 - Archivos de la Sociedad Española de Oftalmología UR - https://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S0365-66912005000500006&lng=es&nrm=iso&tlng=es VL - 80 ER - TY - GEN AU - Cirarda, Patxi PY - 2018 SP - 45 EP - 45 TI - Estrategia Terrioorial de Bilbao metropolitano ER - TY - JOUR AU - López García, JS AU - García Lozano, I AU - Smaranda, A AU - Martínez Garchitorena, J IS - 5 PB - Sociedad Española de Oftalmología PY - 2005 SP - 289 EP - 296 TI - Estudio comparativo del test de Schirmer y BUT en relación con la etiología y gravedad del ojo seco T2 - Archivos de la Sociedad Española de Oftalmología VL - 80 ER - TY - JOUR AB - PURPOSE. TO present a new indicator that measures the sulci of the lacrimal lake of the eye according to the degrees of ocular abduction at which they vanish. This new approach will help determine the severity and progression of mucosal retraction in ocular surface diseases. METHODS. A total of 181 eyes of 94 healthy persons, 130 eyes of 65 patients with Sjögren's syndrome, and 30 eyes of 15 patients with ocular pemphigoid were examined using the slit lamp. We recorded the vanishing point of the three main lacunar sulci (plico-bulbar, plico-caruncular and dermo-caruncular) while abducting. RESULTS. In healthy persons, the average vanishing points for the first and second lacunar sulci were respectively, 53.2° ± 12.3 and 54.5° ± 9.8. In patients with Sjögren's syndrome, 49.53° ± 10.81 and 53.17°±7.28 and in patients with incipient ocular cicatricial pemphigoid, 42.69° ± 14.33 and 44.46° ± 16.85. Statistical significance was p < 0.005. CONCLUSIONS. The lacunar sulci are shallower and vanish sooner in ocular cicatricial pemphigoid and Sjögren syndrome than in normals. Investigating the vanishing point of the lacunar sulci while abducting is useful for grading the shrinkage of the conjunctiva, caruncle and medial canthus. AU - Murube, J. AU - ChenZhuo, L. AU - Murube, E. AU - Rivas, L. AU - Shalaby, O. DO - 10.1177/112067210101100303 IS - 3 KW - Dry eye KW - Keratoconjunctivitis sicca KW - Lacunar sulci KW - Ocular pemphigoid KW - Pterygium KW - Sjögren's syndrome PY - 2001 SP - 227 EP - 232 TI - Measuring the lacunar sulci as a new indicator of shrinkage of the ocular surface T2 - European Journal of Ophthalmology VL - 11 ER - TY - JOUR AB - Resumen La percepción es el proceso activo de localización y extracción de la información obtenida del medio externo que se organiza en sistemas perceptuales, los cuales realizan el proceso de búsque-da y obtención de la información. Las habilidades perceptuales visuales son las encargadas de la organización y el procesamiento de la información a nivel visual formando parte de la percepción visual y colaborando en el desarrollo cognitivo. el entrenamiento de las habilidades perceptua-les visuales y su integracion con dispositivos básicos de aprendizaje es una forma de mejorar el aprendizaje viso-perceptual y por ende la adaptación al medio, aun cuando todavía no se conocen completamente los mecanismos neuronales que dan el sustrato de la integración visoperceptual. Palabras clave: percepción visual, ha-bilidades perceptuales visuales, aprendizaje, aprendizaje visopercep-tual. AbstRACt Perception is the active process of locating and extracting data from the outer environment. It is organized in perceptual systems in charge of searching and acquiring information. Visual per-ceptual skills are responsible for organizing and processing information on a visual level as part of visual perception and supporting cognitive development. training of visual perceptual skills and its integration to basic learning devices is a way to improve visual perception learning and thus the adaptation to the environment, despite not knowing the neuronal mechanisms that generate visual perception. AU - Merchan Price, Maria Susana AU - Henao Calderon, Jose Luis DO - 10.19052/sv.221 IS - 1 KW - aprendizaje KW - aprendizaje visoperceptual KW - habilidades perceptuales visuales KW - learning KW - percepción visual KW - visual perception KW - visual perception, visual perceptual skills, learn KW - visual perceptual learning KW - visual perceptual skills PY - 2011 SP - 93 EP - 101 TI - Influencia de la percepción visual en el aprendizaje T2 - Ciencia & Tecnología para la Salud Visual y Ocular VL - 9 ER - TY - JOUR AB - En materia social, Colombia enfrenta el gran desafío de articular el desarrollo eco- nómico con el social; para lograrlo, el Plan Nacional de Desarrollo 2010-2014 (Depar- tamento Nacional de Planeación DNP, 2011) cimienta la prosperidad para todos en ocho grandes pilares: 1) convergencia y desarrollo regional; 2) crecimiento y compe- titividad; 3) igualdad de oportunidades; 4) consolidación de la paz; 5) innovación; 6) sostenibilidad ambiental; 7) buen gobierno; y 8) relevancia internacional. De acuerdo con el Plan Nacional de Desarrollo 2010-2014, Colombia enfrenta grandes retos en el tema de salud pública, muchos de ellos originados en las grandes diferencias que existen entre regiones y entre grupos poblacionales: […] si bien la política de salud pública, y sus instrumentos, reconocen las diferen- cias territoriales, en muchos casos la gestión departamental y municipal evidencia debilidades en eficiencia, prioritzación y focalización de los recursos disponibles, lo que contribuye a la persistencia de disparidades entre regiones y entidades territo- riales. (Plan Nacional de Desarrollo 2010-2014) El Plan Decenal de Salud Pública PDSP 2012-2021 es una apuesta política por la equi- dad en salud, entendida como la “ausencia de diferencias en salud entre grupos so- ciales consideradas innecesarias, evitables e injustas” (Whitehead, 1992). Esto implica que la equidad en salud se logra cuando todas las personas alcanzan su potencial de salud independientemente de sus condiciones sociales, culturales y económicas. 27 AU - Ministerio de Salud y Protección Social PY - 2012 SN - 9788578110796 SP - 12 EP - 538 TI - Plan decenal de salu publica 2012-2021 T2 - Ministerio de salud y proteccion social UR - https://www.minsalud.gov.co/salud/publica/epidemiologia/Paginas/cargue-planes-territoriales-de-salud.aspx ER - TY - JOUR AB - La contaminación visual se define como un efecto perceptual, compuesto de desorden y exceso de imágenes dentro del campo visual. El presente estudio tuvo por propósito establecer niveles de carga visual, manifestados en 13 paisajes urbanos de la ciudad de Bogotá (Colombia). Se quisieron establecer niveles de asociación entre las diferentes variables que aportan en los índices de carga visual (ICVi), al igual que la diferencia que existe entre la contaminación visual detectada en dos planos distintos del campo visual (uno inferior y otro superior) en relación al horóptero visual vertical de los observadores. 130 personas participaron en el estudio. Para definir los niveles de carga visual, se implementó la metodología del trazado de retículas sobre fotografías, por las que se emula la disposición de los estímulos visuales en la imagen retiniana. Se concluye que la carga visual es mayor cuando los objetos están al nivel o por debajo de los 15° en el campo visual. Los estímulos visuales que están por encima de los 15°, si bien aportan carga visual, suponen un índice de contaminación visual significativamente menor. AU - Arango, Carlos Andrés AU - Rodríguez-Martínez, Guillermo AU - Marroquín-Ciendúa, Fernando DO - 10.19053/20278306.v11.n2.2021.12762 IS - 2 KW - carga vi- KW - contaminación visual KW - entorno urbano KW - sual KW - urbanismo PY - 2021 SP - 373 EP - 386 TI - La contaminación visual en bogotá: análisis de cargas visuales en localidades con alta estimulación publicitaria T2 - Revista de Investigación, Desarrollo e Innovación VL - 11 ER - TY - JOUR AB - Yeasts of the Cryptococcus genus are distributed in nature associated to animal and vegetal organic residues. Occasionally, species other than C. neoformans may be responsible for infectious diseases in human and animals. This study aims to determine the occurrence of Cryptococcus species in the atmosphere and bird droppings in the city of Ribeirão Preto, São Paulo, Brazil, and to evaluate three virulence factors: capsule formation, growth at 37 °C and melanin production. We analyzed 86 environmental samples (54 droppings and 32 air). Of the 41 strains isolated, 15 were C. neoformans var. neoformans (12 droppings and 3 air), 15 C. albidus (12 droppings and 3 air), 9 C. laurentii (7 droppings and 2 air) and 2 C. uniguttulatus (from droppings). Capsules were produced by 93.3% of C. neoformans var. neoformans, 66.7% of C. albidus, 88.9% of C. laurentii and 50% (1/2) of C. uniguttulatus. All strains of C. neoformans, 20% of C. albidus and 44.4% of C. laurentii were able to grow at 37 °C. The melanin production on DOPA agar was verified in C. neoformans (93.3%), C. albidus (26.7%) and C. laurentii (66.7%). We concluded that different Cryptococcus species coexist in the same ecological niche and they are able to produce virulence factors. © 2007 Elsevier GmbH. All rights reserved. AU - Pedroso, Reginaldo S. AU - Ferreira, Joseane C. AU - Candido, Regina C. DO - 10.1016/j.micres.2007.01.002 IS - 2 KW - Bird droppings KW - Cryptococcosis KW - Cryptococcus spp. KW - Saprophytic sources PY - 2009 SP - 221 EP - 227 TI - The isolation and characterization of virulence factors of Cryptococcus spp. from saprophytic sources in the city of Ribeirão Preto, São Paulo, Brazil T2 - Microbiological Research VL - 164 ER - TY - JOUR AU - Corrales, Carmen Sofla AU - Ordonez, Nelly AU - Londoño, Luisa Marcela AU - Castaneda, Elizabeth IS - 12 PY - 1987 TI - Determinacion de anticuerpos contra cryptococcus neoformans en un grupo de colombofilos T2 - Biomedica VL - 7 ER - TY - JOUR AB - La criptococosis es una enfermedad micótica oportunista grave causada por Cryptococcus neoformans un hongo levaduriforme y encapsulado. Sus dos variedades; Cryptococcus neoformans var. neoformans (serotipos A y D) y Cryptococcus neoformans var. gattii (serotipos B y C) son responsables de enfermedad en el hombre. La infección ocurre por inhalación del microorganismo presente en el excremento principalmente de las palomas. Produce una infección pulmonar inicial desde donde se disemina a otros órganos sobre todo meninges y sistema nervioso central causando una meningoencefalitis; puede diseminarse a piel y vísceras.1 La criptococosis afecta con mayor frecuencia a personas inmunosuprimidas, en especial pacientes con SIDA. En este trabajo se revisa el estado actual de la enfermedad, con atención especial a los cuadros clínicos, el abordaje diagnóstico y el tratamiento. Palabras clave. Criptococosis, Cryptococcus neoformans, meningoencefalitis, micosis oportunista, palomas. AU - Vásquez, Oscar AU - Martínez, Ignacio AU - Campos, Teresita IS - 1 KW - Epidemiología KW - criptococosis KW - cryptococcus neoformans KW - meningoencefalitis KW - micosis oportunista KW - palomas KW - tratamiento PY - 2005 SN - 4236408260 SP - 18 EP - 28 TI - Criptococosis. Historia natural y estado actual del tratamiento T2 - Acta Pediatr Mex VL - 26 ER - TY - BOOK AB - Cryptococcus neoformans is a fungal pathogen that causes almost half a million deaths each year. It is believed that most humans are infected with C. neoformans, possibly in a form that survives through latency in the lung and can reactivate to cause disease if the host becomes immunosuppressed. C. neoformans has a remarkably sophisticated intracellular survival capacities yet it is a free-living fungus with no requirement for mammalian virulence whatsoever. In this review, we discuss the tools that C. neoformans possesses to achieve survival, latency and virulence within its host. Some of these tools are mechanisms to withstand starvation and others aim to protect against microbicidal molecules produced by the immune system. Furthermore, we discuss how these tools were acquired through evolutionary pressures and perhaps accidental stochastic events, all of which combined to produce an organism with an unusual and unique intracellular pathogenic strategy. © 2014 Elsevier Inc. AU - Coelho, Carolina AU - Bocca, Anamelia Lorenzetti AU - Casadevall, Arturo DO - 10.1016/B978-0-12-800261-2.00001-3 ET - 1 KW - Amoeba-macrophage KW - Antimicrobial mechanisms KW - Capsule KW - Evolution KW - Fungal immunity KW - Pbl1 KW - Trojan horse KW - Virulence factors PB - Elsevier Inc. PY - 2014 SN - 9780128002612 SP - 1 EP - 41 TI - The Tools for Virulence of Cryptococcus neoformans T2 - Advances in Applied Microbiology UR - http://dx.doi.org/10.1016/B978-0-12-800261-2.00001-3 VL - 87 ER - TY - JOUR AB - Cryptococcal infections are classically associated to HIV/AIDS patients without therapy, but its presence among other immunosuppressed patients is less recognized. We report 3 lethal cases in non HIV-patients. Two of them presented with meningitis associated to renal transplant or corticosteroid use and, the third, with a necrotic skin infection in the context of progressive liver cirrhosis. In the former two patients, meningeal infection was suspected late, and in the latter, the diagnosis was established postmortem. Cryptococcal infections in non-HIV immunosupressed patients can affect different sites, are suspected late and have a high case-fatality ratio. AU - Fica, Alberto AU - Soto, Andrés AU - Dabanch P, Jeannette AU - Pinilla, Jorge AU - Porte, Lorena DO - 10.4067/S0716-10182015000200011 IS - 1 KW - Cryptococcus KW - Immunosuppression KW - Liver cirrhosis KW - Meningitis KW - Peritonitis PY - 2015 SP - 73 EP - 79 TI - Criptococosis en pacientes inmunosuprimidos sin infección por VIH/SIDA: Un nuevo problema clínico en Chile T2 - Revista Chilena de Infectologia VL - 32 ER - TY - JOUR AB - Los productores de pollo y gallinas así como aves para cacería deben estar consientes que algunas enfermedades de las aves pueden ser transmitidas a los humanos. Es importante hacer notar, sin embargo, que tales enfermedades no son tan comunes como para desalentar a los productores de aves. Para la mayoría de la gente las enfermedades de las aves no son cosa seria, pero los productores de aves deben de estar alertas y buscar asistencia medica si es necesario. Zoonos AU - Gaskin, J M AU - Wilson, H R AU - Mather, F B AU - Jacob, J P AU - Garcia, J C KW - Aves KW - Enfermedades KW - Zoonosis PY - 2013 SP - 6 EP - 6 TI - Enfermedades Aves Transmisibles Humanos T2 - University of Florida UR - http://ufdcimages.uflib.ufl.edu/IR/00/00/16/18/00001/AN09900.pdf ER - TY - JOUR AB - Cryptococcus gattii causes life-threatening disease in otherwise healthy hosts and to a lesser extent in immunocompromised hosts. The highest incidence for this disease is on Vancouver Island, Canada, where an outbreak is expanding into neighboring regions including mainland British Columbia and the United States. This outbreak is caused predominantly by C. gattii molecular type VGII, specifically VGIIa/major. In addition, a novel genotype, VGIIc, has emerged in Oregon and is now a major source of illness in the region. Through molecular epidemiology and population analysis of MLST and VNTR markers, we show that the VGIIc group is clonal and hypothesize it arose recently. The VGIIa/IIc outbreak lineages are sexually fertile and studies support ongoing recombination in the global VGII population. This illustrates two hallmarks of emerging outbreaks: high clonality and the emergence of novel genotypes via recombination. In macrophage and murine infections, the novel VGIIc genotype and VGIIa/major isolates from the United States are highly virulent compared to similar non-outbreak VGIIa/major-related isolates. Combined MLST-VNTR analysis distinguishes clonal expansion of the VGIIa/major outbreak genotype from related but distinguishable less-virulent genotypes isolated from other geographic regions. Our evidence documents emerging hypervirulent genotypes in the United States that may expand further and provides insight into the possible molecular and geographic origins of the outbreak. © 2010 Byrnes et al. AU - Byrnes, Edmond J. AU - Li, Wenjun AU - Lewit, Yonathan AU - Ma, Hansong AU - Voelz, Kerstin AU - Ren, Ping AU - Carter, Dee A. AU - Chaturvedi, Vishnu AU - Bildfell, Robert J. AU - May, Robin C. AU - Heitman, Joseph DO - 10.1371/journal.ppat.1000850 IS - 4 PY - 2010 SP - 1 EP - 16 TI - Emergence and pathogenicity of highly virulent Cryptococcus gattii genotypes in the Northwest United States T2 - PLoS Pathogens VL - 6 ER - TY - JOUR AB - The pathogenicity of Cryptococcus neoformans is heterogeneous and is associated with the expression of virulence factors. This study aimed to correlate the pathogenicity of C. neoformans var. grubii in BALB/c mice with in vitro virulence factors, fluconazole minimal inhibitory concentrations (MICs) and molecular profiles, before and after animal passage. Ten environmental isolates and one ATCC strain of C. neoformans var. grubii mating type α were evaluated. Most isolates (91%) killed 50% or more of the infected animals by day 24 postinfection and were recovered from the lungs and brains of surviving animals on days 7 and 14 postinfection. The burden of yeast in the lungs was more variable than that in the brain. The differences in the expression of virulence factors (growth at 37°C, presence and size of the capsule and production of melanin, urease, proteinase and phospholipase) by most isolates pre and postpassage in animals were not statistically significant. The fluconazole MICs in postpassaged lines differed by a one-dilution from the MIC of the corresponding prepassaged line for six isolates. Using molecular typing [polymerase chain reaction-fingerprinting with (GACA)4 and M13], eight isolates were identified as VNI and three as VNII. We concluded that different isolates with the same molecular and phenotypic profiles, including isolates that are markedly hypervirulent, span a wide range of virulence and there were no changes in virulence factors in the postpassaged lines when compared with the corresponding nonpassaged lines. AU - Pedroso, Reginaldo S. AU - Lavrador, Marco A.S. AU - Ferreira, Joseane C. AU - Candido, Regina C. AU - Maffei, Claudia M.L. DO - 10.1590/S0074-02762010000800008 IS - 8 KW - Cryptococcus neoformans KW - Molecular typing KW - Pathogenicity KW - Virulence factors PY - 2010 SP - 993 EP - 1000 TI - Cryptococcus neoformans var. grubii - Pathogenicity of environmental isolates correlated to virulence factors, susceptibility to fluconazole and molecular profile T2 - Memorias do Instituto Oswaldo Cruz VL - 105 ER - TY - JOUR AU - Mart, Ignacio AU - Rivera, Teresita Campos IS - 1 KW - criptococosis KW - cryptococcus neoformans KW - meningoencefalitis KW - micosis oportunista KW - palomas PY - 2005 SP - 18 EP - 28 TI - Criptococosis. Historia natural y estado actual del tratamiento T2 - Historia UR - https://www.medigraphic.com/pdfs/actpedmex/apm-2005/apm051e.pdf VL - 26 ER - TY - JOUR AB - 3 pediatric cases of meningoencephalitis caused by Cryptococcus neoformans serotype A are described. The diagnosis was made by direct examination of the cerebrospinal fluid with India ink. Headache, fever, photophobia and meningeal signs were the predominant clinical manifestations. Although the HIV infection was discarded, cellular immunity compromise was observed in all patients. The evolution was unfavorable in one case and coincided with a late diagnosis of the disease. The treatment with antifungal agents of systemic action (amphotericin B and/or fluconazole) was effective in all cases. AU - Álvarez Lam, Ileana AU - Velázquez Acosta, Juan Carlos AU - Ponce Bittar, Jorge AU - Gaya, José Antonio IS - 1 PY - 2001 SP - 55 EP - 59 TI - Criptococosis infantil: Presentación de 3 casos T2 - Revista Cubana de Pediatria VL - 73 ER - TY - JOUR AB - Volumen 16, Suplemento 3 -Infecciones Fúngicas, Diciembre de 2012 ¿Es necesario el diagnóstico temprano de la criptococosis? La criptococosis meníngea es una de las principales causas de muerte en los pacientes con síndrome de inmunode-ficiencia adquirida (sida). Se estima que afecta al año a casi un millón de individuos virus de la inmunodeficiencia humana (VIH) positivos en el mundo, y a las 2 terceras partes de ellos les causa la muerte. La inmensa mayoría de estos pacientes viven en el África Subsahariana, y se calcula que allí esta micosis causa más muertes que la tuberculosis 1 . La criptococosis es la principal causa de meningitis comprobada por cultivo, en adultos en Sudáfrica y en otros países de la región suroccidental del continente africano 2 . Esta alta prevalencia se mantiene, no obstante, los grandes adelantos que se han logrado en el mundo con la terapia antirretroviral (TAR), debido a que solo un 37% de los pacientes de los países con ingresos medios y bajos la reciben 3 . En nuestro país, el Grupo Colombiano para el Estudio de la Criptococosis ha señalado una incidencia de 2,4 casos por millón de habitantes en la población general; sin embargo, esta incidencia es más de mil veces mayor en la población VIH positiva (3,0 a 3,3 por mil personas) 4,5 . Ade-más, en Colombia, la criptococosis meníngea es la segunda infección oportunista más frecuente del sistema nervioso central en los pacientes VIH positivos, solo superada por la toxoplasmosis cerebral 6-9 . En Colombia, la mayoría los pacientes con sida no están recibiendo TAR en el momento de presentarse la criptoco-cosis meníngea y, usualmente, sus células CD4+ están por debajo de 100/μL, siendo altas sus cargas virales 10 . Ade-más, al 20% de estos pacientes se les suele diagnosticar la criptococosis meníngea en los primeros 3 meses de iniciada la TAR 11 . Datos de la Organización Mundial de la Salud señalan que en Colombia a diciembre de 2010, solo el 34% de los pacientes infectados por el VIH estaban recibiendo TAR 12 , cifra que se aproxima al 23,8% encontrado en un estudio de pacientes con criptococosis meníngea realizado en un hospital del tercer nivel de Cúcuta 10 . Los pacientes con criptococosis meníngea requieren de tratamientos complejos y de hospitalizaciones prolon-gadas (por lo menos 14 días) con unos costos económicos elevados 13 . Según la Infectious Diseases Society of Ame-rica (IDSA), el manejo de la criptococosis continúa siendo un reto, con pocas drogas nuevas o sin estudios recientes definitivos de su eficacia. Sin embargo, si el diagnóstico es hecho tempranamente, si los clínicos se adhieren a los principios básicos de las guías de manejo de IDSA y AU - Lizarazo, Jairo AU - Castañeda, Elizabeth IS - 3 PY - 2012 SP - 94 EP - 99 TI - Consideraciones sobre la criptococosis en los pacientes con sida T2 - Infectio VL - 16 ER - TY - GEN AU - Guerrero Martinez, Erika Yinett AU - Moreno Mora, Eliana Julieth AU - Carrascal Quintero, Kelly Jhoana PY - 2018 SP - 145 EP - 145 TI - Determinación de cryptococcus neoformans y cryptococcus gattii a partir de aislados ambientales provenientes de los parques Santander, mercedes abrego, juana rangel de cuellar y Fuente de leones en el municipio de san jose de cucuta, norte de santander, c ER - TY - JOUR AB - Background and Aims—Cardiovascular disease (CVD) is among the leading causes of morbidity and mortality worldwide. Traditional risk factors predict 75-80% of an individual's risk of incident CVD. However, the role of early life experiences in future disease risk is gaining attention. The Barker hypothesis proposes fetal origins of adult disease, with consistent evidence demonstrating the deleterious consequences of birth weight outside the normal range. In this study, we investigate the role of birth weight in CVD risk prediction. Methods and Results—The Women's Health Initiative (WHI) represents a large national cohort of post-menopausal women with 63 815 participants included in this analysis. Univariable proportional hazards regression analyses evaluated the association of 4 self-reported birth weight categories against 3 CVD outcome definitions, which included indicators of coronary heart disease, ischemic stroke, coronary revascularization, carotid artery disease and peripheral arterial disease. The role of birth weight was also evaluated for prediction of CVD events in the presence of traditional risk factors using 3 existing CVD risk prediction equations: one body mass index (BMI)-based and two laboratory-based models. Low birth weight (LBW) (<6 lbs.) was significantly associated with all CVD outcome definitions in univariable analyses (HR=1.086, p=0.009). LBW was a significant covariate in the BMI-based model (HR=1.128, p<0.0001) but not in the lipid-based models. Conclusion—LBW (<6 lbs.) is independently associated with CVD outcomes in the WHI cohort. This finding supports the role of the prenatal and postnatal environment in contributing to the development of adult chronic disease. AU - Perfect, John R AU - Bicanic, Tihana DO - 10.1016/j.fgb.2014.10.003.Cryptococcosis IS - 10 KW - asian americans KW - depression KW - osteoarthritis KW - pain KW - quantitative sensory testing PY - 2017 SP - 139 EP - 148 TI - Cryptococcosis Diagnosis and Treatment: What Do We Know Now T2 - Physiology & behavior UR - file:///C:/Users/Carla%0ACarolina/Desktop/Artigos%0Apara%0Aacrescentar%0Ana%0Aqualificação/The%0Aimpact%0Aof%0Abirth%0Aweight%0Aon%0Acardiovascular%0Adisease%0Arisk%0Ain VL - 176 ER - TY - JOUR AB - Cryptococcus gattii is a fungal pathogen of humans, causing pulmonary infections in otherwise healthy hosts. To characterize genomic variation among the four major lineages of C. gattii (VGI,-II,-III, and-IV), we generated, annotated, and compared 16 de novo genome assemblies, including the first for the rarely isolated lineages VGIII and VGIV. By identifying syntenic regions across assemblies, we found 15 structural rearrangements, which were almost exclusive to the VGI-III-IV lineages. Using synteny to inform orthology prediction, we identified a core set of 87% of C. gattii genes present as single copies in all four lineages. Remarkably, 737 genes are variably inherited across lineages and are overrepresented for response to oxidative stress, mitochondrial import, and metal binding and transport. Specifically, VGI has an expanded set of iron-binding genes thought to be important to the virulence of Cryptococcus, while VGII has expansions in the stress-related heat shock proteins relative to the other lineages. We also characterized genes uniquely absent in each lineage, including a copper transporter absent from VGIV, which influences Cryptococcus survival during pulmonary infection and the onset of meningoencephalitis. Through inclusion of population-level data for an additional 37 isolates, we identified a new transcontinental clonal group that we name VGIIx, mitochondrial recombination between VGII and VGIII, and positive selection of multidrug transporters and the iron-sulfur protein aconitase along multiple branches of the phylogenetic tree. Our results suggest that gene expansion or contraction and positive selection have introduced substantial variation with links to mechanisms of pathogenicity across this species complex. AU - Farrer, Rhys A. AU - Desjardins, Christopher A. AU - Sakthikumar, Sharadha AU - Gujja, Sharvari AU - Saif, Sakina AU - Zeng, Qiandong AU - Chen, Yuan AU - Voelz, Kerstin AU - Heitman, Joseph AU - May, Robin C. AU - Fisher, Matthew C. AU - Cuomo, Christina A. DO - 10.1128/mbio.00868-15 IS - 5 PY - 2015 SP - 1 EP - 12 TI - Genome evolution and innovation across the four major lineages of cryptococcus gattii T2 - mBio VL - 6 ER - TY - JOUR AB - Cryptococosis is a systemic mycosis whose evolution may be subacute, chronic and occasionally acute; it endangers the patient's life and although the agent penetrates through inhalation, it usually spreads out towards the central nervous system. It is produced by a capsulated yeast, Cryptococcus neoformans. This fungus has two varieties, C. neoformans, var. neoformans with a universal geographic distribution, and C. neoformans, var. gatti which only involves the tropical and subtropical areas. Its perfect phase is called Filobasidiella neoformans. The most frequent clinical forms are pulmonary and meningoencephalic cryptococosis. Involvement of other organs is less frequent, although cutaneous lesions become especially relevant with a view to an early diagnosis. Diagnosis is based on the presence of this yeast in LCR, sputum, cultures, biopsies, etc. by means of the examination with the help of Chinese ink and other cultures in various media. The search for capsular polysacharride antigen is also very useful because of its sensitivity and specificity. Histopathological studies always have to be performed with the help of stains which enable to visualize the capsule. The treatment of choice is an association between amphotericine B and 5-fluorocytosine in the disseminated forms; in the pulmonary and extrapulmonary forms of immunocompetent patients the azolics give good results. Immunodepressed patients require a suppressive treatment for life. AU - Tello, Mercedes AU - Gutierrez, Ericson AU - Bejar, Vilma AU - Galarza, Carlos AU - Ramos, Willy AU - Ortega-Loayza, Alex DO - 10.1016/s0213-9251(01)72474-4 IS - 2 KW - Cryptococcus neoformans KW - Cryptococius neoformans KW - clinic KW - cryptococosis KW - etiopathogeny KW - treatment KW - var. gattii KW - var. neoformans PY - 2013 SP - 147 EP - 153 TI - Criptococosis T2 - rev ned risaralda VL - 19 ER - TY - GEN AU - Acevedo Almendarez, Lilia Mercedes PY - 2015 SP - 96 EP - 96 TI - Genotipos de aislamientos de Cryptococcus de pacientes y muestras ambientales del Instituto Nacional Cardiopulmonar, utilizando PCR-RFLP URA5- Tegucigalpa, Honduras, 2015. ER - TY - JOUR AB - Antecedentes: La criptococosis es una micosis invasiva causada principalmente por Criptococcusneoformans. Esta enfermedad afecta sobre todo a pacientes inmunosuprimidos, particularmente pacientes con infección por VIH pero también puede afectar inmunocompetentes. Las formas de presentación clínica más frecuentes son meningitis y afectación pulmonar. Metodología: En este trabajo se pretende determinar el perfil epidemiológico, las características clínicas y la respuesta al tratamiento de los pacientes con criptococosis en el Hospital San Juan de Dios,período 2008-2012; diagnosticados en el laboratorio de bacteriología del hospital. Se obtienen los datos mediante un estudio observacional de revisión de expedientes de una muestra final de 33 expedientes. Resultados:De la muestra analizada un 78,8% fue del género masculino con una mediana de edad de 40,1 ± 11.9 años. El 72,7% tenía enfermedad por VIH,20% inmunocompetentes y 9.1% inmunosupresión farmacológica sobre todo por patologías autoinmunes. La presentación clínica fue 72.7 % como meningitis, 12.2 % pulmonar, 9.1 % forma diseminada y 6.1 % forma cutánea. La forma meníngea predominó en pacientes con VIH y la pulmonar en inmunocompetentes. La especie identificada fue C. neoformans87.9 %, C. laurentii 9.1 % y C. uniguttulatus 3%.La tinta chinacomo método diagnóstico mostró una sensibilidad de 25 % en VIH negativos y 58 % en VIH positivos. Se le suministró anfotericina B deoxicolatoal 100 % de los pacientes con VIH y 44 % de los VIH negativos. El 30 % de los pacientes con VIH falleció y ninguno de los VIH negativos. Conclusiones: La criptocosis es una micosis que afecta fundamentalmente adultos jóvenes inmunocomprometidos, particularmente en pacientes VIH positivos men fase de SIDA. Meningitis es la presentación más frecuente, y la forma pulmonar predominó en inmunocompetentes. Todos los pacientes coinfectados recibieron anfotericina B deoxicolato de tratamiento y aún así tuvieron una mortalidadde 30 %. AU - Ávila Sánchez, Diego AU - Vindas Villalobos, Manuel Antonio V DO - 10.15517/rc_ucr-hsjd.v6i1.23055 IS - 1 PY - 2016 TI - Perfil epidemiológico y respuesta terapéutica de la infección por Cryptococcus sp. en pacientes de Costa Rica en el Hospital San Juan de Dios, Período 2008-2012 T2 - Revista Clínica Escuela de Medicina UCR-HSJD VL - 6 ER - TY - JOUR AU - Hurtado, Isabel C AU - Lopez, Pio AU - Osorio, Miguel A AU - López-medina, Eduardo IS - 2 PY - 2016 SP - 93 EP - 6 TI - Criptococosis congénita en un neonato expuesto a VIH: presentación de un caso T2 - Elsevier VL - 20 ER - TY - JOUR AB - Cryptococcus neoformans is a pathogenic basidiomycetous yeast that can cause life-threatening meningoencephalitis in immuno-compromized patients. To propagate in the human body, this organism has to acquire phosphate that functions in cellular signaling pathways and is also an essential component of nucleic acids and phospholipids. Thus it is reasonable to assume that C. neoformans (Cn) possesses a phosphate regulatory system (PHO system) analogous to that of other fungi. By BLAST searches using the amino acid sequences of the components of the PHO system of Saccharomyces cerevisiae (Sc), we found potential counterparts to ScPHO genes in C. neoformans, namely, acid phosphatase (. CnPHO2), the cyclin-dependent protein kinase (CDK) inhibitor (. CnPHO81), Pho85-cyclin (. CnPHO80), and CDK (. CnPHO85). Disruption of each candidate gene, except CnPHO85, followed by phenotypic analysis, identified most of the basic components of the CnPHO system. We found that CnPHO85 was essential for the growth of C. neoformans, having regulatory function in the CnPHO system. Genetic screening and ChIP analysis, showed that CnPHO4 encodes a transcription factor that binds to the CnPHO genes in a Pi-dependent manner. By RNA-seq analysis of the wild-type and the regulatory mutants of the CnPHO system, we found C. neoformans genes whose expression is controlled by the regulators of the CnPHO system. Thus the CnPHO system shares many properties with the ScPHO system, but expression of those CnPHO genes that encode regulators is controlled by phosphate starvation, which is not the case in the ScPHO system (except ScPHO81). We also could identify some genes involved in the stress response of the pathogenic yeast, but CnPho4 appeared to be responsible only for phosphate starvation. AU - Toh-e, Akio AU - Ohkusu, Misako AU - Li, Hao Man AU - Shimizu, Kiminori AU - Takahashi-Nakaguchi, Azusa AU - Gonoi, Toru AU - Kawamoto, Susumu AU - Kanesaki, Yu AU - Yoshikawa, Hirofumi AU - Nishizawa, Masafumi DO - 10.1016/j.fgb.2015.04.019 KW - ChIP-seq KW - CnPHO system KW - Cryptococcus neoformans KW - PHO-regulatory genes KW - RNA-seq PB - Elsevier Inc. PY - 2015 SP - 19 EP - 30 TI - Identification of genes involved in the phosphate metabolism in Cryptococcus neoformans T2 - Fungal Genetics and Biology UR - http://dx.doi.org/10.1016/j.fgb.2015.04.019 VL - 80 ER - TY - JOUR AB - Although several virulence factors and associated genes have been identified, the mechanisms that allow Cryptococcus neoformans to adapt during chronic infection and to persist in immunocompromised hosts remain poorly understood. Characterization of senescent cells of C. neoformans demonstrated that these cells exhibit a significantly enlarged cell body and capsule but still cross the blood-brain barrier. C. neoformans cells with advanced generational age are also more resistant to phagocytosis and killing by antifungals, which could promote their selection during chronic disease in humans. Senescent cells of RC-2, a C. neoformans strain that undergoes phenotypic switching, manifest switching rates up to 11-fold higher than those of younger cells. Infection experiments with labeled cells suggest that senescent yeast cells can potentially accumulate in vivo. Mathematical modeling incorporating different switching rates demonstrates how increased switching rates promote the emergence of hypervirulent mucoid variants during chronic infection. Our findings introduce the intriguing concept that senescence in eukaryotic pathogens could be a mechanism of microevolution that may promote pathoadaptation and facilitate evasion of an evolving immune response. Copyright © 2009, American Society for Microbiology. All Rights Reserved. AU - Jain, Neena AU - Cook, Emily AU - Xess, Immaculata AU - Hasan, Fahmi AU - Fries, Dietrich AU - Fries, Bettina C. DO - 10.1128/EC.00017-09 IS - 6 PY - 2009 SP - 858 EP - 866 TI - Isolation and characterization of senescent cryptococcus neoformans and implications for phenotypic switching and pathogenesis in chronic cryptococcosis T2 - Eukaryotic Cell VL - 8 ER - TY - JOUR AB - RESUMEN La criptococosis es una enfermedad producida por levaduras encapsuladas que se adquiere por la inhalación de propágulos infectantes de Cryptoccoccus, principalmente por la C. neoformnas y en menor frecuencia por la C. gatti. La distribución de este hongo es global, pero se encuentra de manera habitual en excretas de aves como las palomas. El principal compromiso en las personas es a nivel de los pulmones, del cerebro o de forma dise-minada. La criptococosis en el sistema nervioso central (SNC) se presenta con meningoencefalitis, rara vez en forma de lesiones localizadas granulomatosas conocidas como criptococoma. Esta micosis es una causa frecuente de meningitis que se encuentra, especialmente, en los pacientes con VIH/SIDA. Las manifestacio-nes clínicas de esta enfermedad en el SNC son: cefalea, alteración del estado mental, fiebre, náuseas, vómito, deterioro visual, parálisis del sexto nervio craneal y signos de irritación meníngea, entre otras. El diagnóstico se realiza por medio de cultivo, microscopía del líquido cefalorraquídeo (LCR) o detección del antígeno de criptococo. El tratamiento de la meningitis por criptococo se divide en tres fases: inducción, consolidación y mantenimiento. Los pilares del tratamiento son la anfotericina B, la flucitosina y el fluconazol. AU - Hurtado García, Steven Hurtado García AU - Quintero Cusgüen, Patricia DO - 10.22379/24224022339 IS - 1 supl. 1 KW - anfo- KW - antígenos KW - criptococosis KW - decs KW - fluconazol KW - líquido cefalorraquídeo KW - sistema nervioso central KW - tericina b KW - vih PY - 2021 SP - 90 EP - 100 TI - Criptococosis meníngea T2 - Acta Neurológica Colombiana VL - 37 ER - TY - JOUR AB - More than 110 years of study of the Cryptococcus neoformans and Cryptococcus gattii species complex has resulted in an enormous accumulation of fundamental, applied biological and clinical knowledge. Recent developments in our understanding of the diversity within the species complex are presented, emphasizing the intraspecific complexity, which includes species, microspecies, hybrids, serotypes and genotypes. Each of these may have different roles in disease. An overview of obsolete and current names is presented. ©2008 Revista Iberoamericana de Micología. AU - Rovers, Marjan AU - Hagen, Ferry AU - Boekhout, Teun DO - 10.1016/s1130-1406(08)70019-6 IS - 1 KW - Cryptococcus gattii KW - Cryptococcus neoformans KW - Pathogen KW - Taxonomy KW - Yeast PB - Elsevier PY - 2008 SP - S4 EP - S12 TI - Diversity of the Cryptococcus neoformans-Cryptococcus gattii species complex T2 - Revista Iberoamericana de Micologia VL - 25 ER - TY - JOUR AU - Latino, Gera A. AU - Gago, Emilio AU - Vidau, Pedro AU - Vivanco, Blanca DO - 10.3265/Nefrologia.pre2012.Jun.11563 IS - 5 PY - 2012 SP - 697 EP - 698 TI - Criptococosis cutánea en un paciente que recibe hemodiálisis crónica T2 - Nefrologia VL - 32 ER - TY - JOUR AB - This review describes the importance of the discovery of melanin production in Cryptococcus neo formans and its contribution to diagnosis, clinical evaluation, virulence, genetics and biochemical studies of this important pathogen. © 1991, Gustav Fischer Verlag, Stuttgart · New York. All rights reserved. AU - Polacheck, Itzhack DO - 10.1016/S0934-8840(11)80225-2 IS - 1 PB - Gustav Fischer Verlag, Stuttgart · New York PY - 1991 SP - 120 EP - 123 TI - The Discovery of Melanin Production in Cryptococcus neoformans and its Impact on Diagnosis and the Study of Virulence T2 - Zentralblatt fur Bakteriologie VL - 276 ER - TY - JOUR AB - Unique clinical characteristics and other variables influencing the outcome of Cryptococcus neoformans infection in organ transplant recipients have not been well defined. From a review of published reports, we found that C. neoformans infection was documented in 2.8% of organ transplant recipients (overall death rate 42%). The type of primary immunosuppressive agent used in transplantation influenced the predominant clinical manifestation of cryptococcosis. Patients receiving tacrolimus were significantly less likely to have central nervous system involvement (78% versus 11%, p =0.001) and more likely to have skin, soft-tissue, and osteoarticular involvement (66% versus 21%, p = 0.006) than patients receiving nontacrolimus- based immunosuppression. Renal failure at admission was the only independently significant predictor of death in these patients (odds ratio 16.4, 95% CI 1.9-143, p = 0.004). Hypotheses based on these data may elucidate the pathogenesis and may ultimately guide the management of C. neoformans infection in organ transplant recipients. AU - Husain, S. AU - Wagener, M. M. AU - Singh, N. DO - 10.3201/eid0703.017302 IS - 3 PY - 2001 SP - 375 EP - 381 TI - Cryptococcus neoformans infection in organ transplant recipients: variables influencing clinical characteristics and outcome. T2 - Emerging infectious diseases VL - 7 ER - TY - JOUR AB - The incidence of cryptococcosis rose dramatically with the advent of the acquired immune deficiency syndrome (AIDS) epidemic in the early 1980s until the early 1990s. The frequency of cryptococcosis has been declining since mid 1990s in Europe and America due to the development of more effective antiretroviral therapy and prophylactic treatment regimens designed to prevent fungal infections. The disease, however, is still recognized as one of the most common life-threatening opportunistic fungal infections in immunocompromised patients, particularly among those infected with human immunodeficiency virus (HIV). For this reason, research interest in clinical and biological aspects of the disease remains high. In addition to previously embarked areas of research, the cryptococcal research community has taken advantage of the current sequencing technology and initiated genome sequencing of Cryptococcus neoformans var. neoformans. This review includes various areas of research interest ranging from pathobiology, biochemistry and immunology, to genomics. AU - Kwon-Chung, K. J. AU - Sorrell, T. C. AU - Dromer, F. AU - Fung, E. AU - Levitz, S. M. DO - 10.1080/mmy.38.s1.205.213 IS - April 1997 KW - Cryptococcus neoformans KW - Genomics KW - Immunology PY - 2000 SP - 205 EP - 213 TI - Cryptococcosis: Clinical and biological aspects T2 - Medical Mycology VL - 38 ER - TY - JOUR AB - Although the incidence of HIV-associated cryptococcosis has decreased in developed countries since the introduction of antiretroviral therapy, this disease continues to cause significant morbidity and mortality in sub-Saharan Africa among patients with AIDS. Important strides have been made in an attempt to decrease the burden of disease, particularly the development of the lateral flow assay cryptococcal antigen (LFA CrAg) as a diagnostic tool in resource-limited settings, coupled with the introduction of pre-emptive treatment with fluconazole for HIV-positive patients at risk for cryptococcosis with a positive LFA CrAg. Among solid organ transplant recipients, recent prospective studies have identified cryptococcosis as the third most common invasive fungal infection, and progress is being made toward earlier diagnosis and more effective therapy. Finally, the Cryptococcus gattii outbreak in British Columbia, Canada and the US Pacific Northwest is providing important new insights into the emergence of this pathogen in geographic areas previously considered low risk for acquisition of infection. Understanding the similarities and differences among C. gattii and C. neoformans infections will provide critical insights into the behavior of these organisms in the human host. Both pathogens affect immunocompetent and immunosuppressed hosts, causing pulmonary, central nervous system and widely disseminated infections. Treatment recommendations in the future will necessarily take into account the site of infection, clinical severity of the infection, Cryptococcus species, host immune status and economic resources. © 2013 Springer International Publishing Switzerland. AU - La Hoz, Ricardo M. AU - Pappas, Peter G. DO - 10.1007/s40265-013-0037-z IS - 6 PY - 2013 SP - 495 EP - 504 TI - Cryptococcal infections: Changing epidemiology and implications for therapy T2 - Drugs VL - 73 ER - TY - JOUR AU - Mitchell, T G AU - Perfect, J R DO - 10.1128/cmr.8.4.515-548.1995 IS - 4 PY - 1995 SP - 515 EP - 548 TI - Cryptococcosis in the era of AIDS--100 years after the discovery of Cryptococcus neoformans. T2 - Clinical microbiology reviews VL - 8 ER - TY - JOUR AU - Dc, Washington PY - 2013 SP - 2144 EP - 2146 TI - New Insights into HIV/AIDS-Associated Cryptococcosis Spinello T2 - Isrn Aids VL - 2013 ER - TY - JOUR AB - Cryptococcus gattii causes life-threatening infection of the pulmonary and central nervous systems in hosts with normal immunity and traditionally has been considered to be restricted geographically to tropical and subtropical climates. The recent outbreak of C. gattii in the temperate climate of Vancouver Island, BC, Canada, led to a collaborative investigation. The objectives of the current study were to ascertain the environmental source of the outbreak infections, survey the molecular types of the outbreak and environmental cryptococcal isolates, and determine the extent of genetic diversity among the isolates. PCR-fingerprinting and amplified fragment length polymorphism (AFLP) were used to examine the genotypes, and mating assays were performed to determine the mating type of the isolates. All outbreak and environmental isolates belonged to C. gattii. Concordant results were obtained by using PCR-fingerprinting and AFLP analysis. The vast majority of clinical and veterinary infections were caused by isolates of the molecular type VGII/AFLP6, but two were caused by molecular type VGI/AFLP4. All environmental isolates belonged to molecular type VGII/AFLP6. Two or three subtypes were observed within VGII/AFLP6 among outbreak and environmental isolates. All mating-competent isolates were of the α-mating type. The emergence of this usually tropical pathogen on Vancouver Island highlights the changing distribution of this genotype and emphasizes the importance of an ongoing collaborative effort to monitor the global epidemiology of this yeast. AU - Kidd, S. E. AU - Hagen, F. AU - Tscharke, R. L. AU - Huynh, M. AU - Bartlett, K. H. AU - Fyfe, M. AU - MacDougall, L. AU - Boekhout, T. AU - Kwon-Chung, K. J. AU - Meyer, W. DO - 10.1073/pnas.0402981101 IS - 49 KW - Amplified fragment length polymorphism (AFLP) KW - Mating type KW - PCR fingerprinting KW - Restriction fragment length polymorphism (RFLP) PY - 2004 SP - 17258 EP - 17263 TI - A rare genotype of Cryptococcus gattii caused the cryptococcosis outbreak on Vancouver Island (British Columbia, Canada) T2 - Proceedings of the National Academy of Sciences of the United States of America VL - 101 ER - TY - JOUR AB - Objectives: The aim of this study was to determine the long-term incidence of cryptococcosis in kidney transplant recipients (KTRs) and to analyze its risk factors. Methods: This retrospective population-based cohort study analyzed data obtained from Taiwan's National Health Insurance Research Database for KTRs during 2000–2012 and matched cohorts. Both populations were followed until death, development of cryptococcosis, or December 2013. Results: A total of 4,933 KTRs and 49,930 matched patients were included. The cryptococcosis incidence rates for the KTR cohort and matched cohort were 10.59 and 0.4 per 10,000 person-years, respectively. The hazard ratio for cryptococcosis among KTRs was 26.65 (p < 0.001); and 43.77 (p < 0.001) for cryptococcosis affecting the central nervous system (CNS). The Kaplan-Meier method confirmed an elevated cumulative incidence of cryptococcosis among KTRs (1.00% vs. 0.04%). Predictors for cryptococcosis were advanced age (OR 1.39, 95% CI 1.02–1.89, P = 0.038) and cancer (OR 2.63, 95% CI 1.22–5.67, P = 0.013), but not the use of any particular class of immunosuppressants. Conclusions: KTRs are at dramatically higher risk of developing cryptococcosis, especially with CNS involvement, relative to a non-KTR matched cohort. Older KTRs and those with cancer are at even higher risk of developing cryptococcosis. AU - Chen, Yung Tai AU - Lee, Wen Sen AU - Tsai, Che An AU - Fan, Wen Chien AU - Wu, Ping Feng AU - Wang, Fu Der DO - 10.1016/j.ijid.2019.08.021 KW - Cryptococcosis KW - Epidemiology KW - Kidney transplant recipients PB - International Society for Infectious Diseases PY - 2019 SP - 154 EP - 158 TI - Incidence of and risk factors for cryptococcosis in kidney transplant recipients in Taiwan—A nationwide population-based study T2 - International Journal of Infectious Diseases UR - https://doi.org/10.1016/j.ijid.2019.08.021 VL - 88 ER - TY - JOUR AU - Harrison, Thomas S. DO - 10.1097/QAD.0b013e328322ffc3 IS - 4 PY - 2009 SP - 531 EP - 532 TI - The burden of HIV-associated cryptococcal disease T2 - Aids VL - 23 ER - TY - JOUR AB - Over the past 40 years, rigorous examination of brain function, structure, and attending factors through multidisciplinary research has helped identify the substrates of alcohol-related damage in the brain. One main area of this research has focused on the neuropsychological sequelae of alcoholism, which has resulted in the description of a pattern of sparing and impairment that provided an essential understanding of the functional deficits as well as of spared capabilities that could be useful in recovery. These studies have elucidated the component processes of memory, problem solving, and cognitive control, as well as visuospatial, and motor processes and their interactions with cognitive control processes. Another large area of research has focused on observable brain pathology, using increasingly sophisticated imaging technologies—progressing from pneumoencephalography to computed tomography, magnetic resonance imaging (MRI), diffusion tensor imaging, and functional MRI—that have enabled ever more detailed insight into brain structure and function. These advancements also have allowed analysis of the course of brain structural changes through periods of drinking, abstinence, and relapse. Keywords AU - Byrnes, Edmond AU - Bartlett, Karen H. AU - Perfectt, John R AU - Heitman, Joseph DO - 10.1016/j.micinf.2011.05.009.Cryptococcus IS - 11 KW - epiblast KW - gfp fusion KW - histone h2b- KW - icm KW - lineage specification KW - live imaging KW - mouse blastocyst KW - pdgfr α KW - primitive endoderm PY - 2011 SN - 6176321972 SP - 895 EP - 907 TI - Cryptococcus gattii: an emerging fungal pathogen infecting humans and animals T2 - Microbes Infect. UR - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3624763/pdf/nihms412728.pdf VL - 13 ER - TY - JOUR AU - Chayakulkeeree, Methee AU - Perfect, John R. DO - 10.1016/j.idc.2006.07.001 IS - 3 PY - 2006 SP - 507 EP - 544 TI - Cryptococcosis T2 - Infectious Disease Clinics of North America VL - 20 ER - TY - JOUR AB - Background: Immune reconstitution inflammatory syndrome (IRIS) in association with cryptococcosis has been anecdotically reported following administration of highly active antiretroviral therapy (HAART). Objective: To analyse the incidence and risk factors for IRIS-associated cryptococcosis among HIV-infected patients. Design: Retrospective multicentre study between 1996 and 2000 through the French Cryptococcosis Database. Methods: Subsequent occurrence of IRIS examined in 120 HIV-infected adult patients treated with HAART and experiencing a first episode of culture-confirmed cryptococcosis. Results: Ten patients developed IRIS during the study period, giving an incidence of 10/239, or 4.2/100 person-years [95% confidence interval (CI), 2.2-7.8]. IRIS consisted of acute symptoms consistent with inflammation occurring within a median of 8 months (range, 2-37) after the diagnosis of cryptococcosis in the context of negative cultures and immunological and/or virological response to HAART. Radiology and histopathology detected features compatible with inflammation. Symptom severity required transfer into intensive care units for three patients and use of anti-inflammatory drugs for four. Three patients with evolutive IRIS died. Compared with patients without IRIS for whom complete clinical and microbiological information were available at baseline, previously unknown HIV infection [odds ratio (OR), 4.8; 95% CI, 1.0-21.7], CD4 cell count <7 × 106 cells/I (OR, 4.0; 95% CI, 0.9-17.2), fungaemia (OR, 6.1; 95% CI, 1.1-35.2) and HAART initiation within 2 months of cryptococcosis diagnosis (OR, 5.50; 95% CI, 1.0-29.6) were independently associated with the risk of subsequent IRIS. Conclusions: IRIS-related cryptococcosis was observed more frequently in severely immunocompromised patients with disseminated infection and HAART initiation soon after the diagnosis. © 2005 Lippincott Williams & Wilkins. AU - Lortholary, Olivier AU - Fontanet, Arnaud AU - Mémain, Nathalie AU - Martin, Antoine AU - Sitbon, Karine AU - Dromer, Françoise DO - 10.1097/01.aids.0000174450.70874.30 IS - 10 KW - AIDS KW - Cryptococcus neoformans KW - Fungaemia KW - HAART KW - IRIS KW - Inflammation PY - 2005 SP - 1043 EP - 1049 TI - Incidence and risk factors of immune reconstitution inflammatory syndrome complicating HIV-associated cryptococcosis in France T2 - Aids VL - 19 ER - TY - JOUR AU - Debenedectis, Carolynn M. AU - McCulloh, Russell J. AU - Healey, Terrance T. IS - 5 KW - 1 KW - 2 KW - 3 KW - aids KW - and KW - and radiological entities during KW - article KW - cryptococcal pneumonia KW - cryptococcus neoformans KW - environment of the disease KW - fluconazole KW - how to diagnose and KW - infection and the KW - know KW - objectives KW - pneumonia KW - readers should KW - recognize the different clinical KW - treat pulmonary cryptococcosis KW - understand cryptococcus neoformans pulmonary KW - upon completion of this PY - 2013 SP - 53 EP - 54 TI - Pulmonary Cryptococcosis T2 - Rhode Island medical journal (2013) VL - 96 ER - TY - JOUR AB - Background: Cryptococcus gattii is a fungal pathogen causing an emerging outbreak in the United States Pacific Northwest (PNW). Treatment guidelines for cryptococcosis are primarily based on data from C. neoformans infections; applicability to PNW C. gattii infection is unknown. We evaluated the relationship between initial antifungal treatment and outcomes for PNW C.gattii patients. Methods: Cases were defined as culture-confirmed invasive C. gattii infections among residents of Oregon and Washington States during 2004-2011. Clinical data were abstracted from medical records through one year of follow-up. Recommended initial treatment for central nervous system (CNS), bloodstream, and severe pulmonary infections is amphotericin B and 5- flucytosine; for non-severe pulmonary infections, recommended initial treatment is fluconazole. Alternative initial treatment was defined as any other initial antifungal treatment. Results: Seventy patients survived to diagnosis; 50 (71%) received the recommended initial treatment and 20 (29%) received an alternative. Fewer patients with pulmonary infections [21 (64%)] than CNS infections [25 (83%)] received the recommended initial treatment (p = 0.07). Among patients with pulmonary infections, those with severe infections received the recommended initial treatment less often than those with non-severe infections (11% vs. 83%, p<0.0001). Eight patients with severe pulmonary infections received alternative initial treatments; three died. Four patients with non-severe pulmonary infections received alternative initial treatments; two died. There was a trend towards increased three-month mortality among patients receiving alternative vs. recommended initial treatment (30% vs. 14%, p = 0.12), driven primarily by increased mortality among patients with pulmonary disease receiving alternative vs. recommended initial treatment (42% vs. 10%, p = 0.07). Conclusions: C.gattii patients with pulmonary infections - especially severe infections - may be less likely to receive recommended treatment than those with CNS infections; alternative treatment may be associated with increased mortality. Reasons for receipt of alternative treatment among C.gattii patients in this area should be investigated, and clinician awareness of recommended treatment reinforced. AU - Smith, Rachel M. AU - Mba-Jonas, Adamma AU - Tourdjman, Mathieu AU - Schimek, Trisha AU - DeBess, Emilio AU - Marsden-Haug, Nicola AU - Harris, Julie R. DO - 10.1371/journal.pone.0088875 IS - 2 PY - 2014 TI - Treatment and outcomes among patients with Cryptococcus gattii infections in the United States Pacific Northwest T2 - PLoS ONE VL - 9 ER - TY - JOUR AB - Unique clinical characteristics and other variables influencing the outcome of Cryptococcus neoformans infection in organ transplant recipients have not been well defined. From a review of published reports, we found that C. neoformans infection was documented in 2.8% of organ transplant recipients (overall death rate 42%). The type of primary immunosuppressive agent used in transplantation influenced the predominant clinical manifestation of cryptococcosis. Patients receiving tacrolimus were significantly less likely to have central nervous system involvement (78% versus 11%, p =0.001) and more likely to have skin, soft-tissue, and osteoarticular involvement (66% versus 21%, p = 0.006) than patients receiving nontacrolimus- based immunosuppression. Renal failure at admission was the only independently significant predictor of death in these patients (odds ratio 16.4, 95% CI 1.9-143, p = 0.004). Hypotheses based on these data may elucidate the pathogenesis and may ultimately guide the management of C. neoformans infection in organ transplant recipients. AU - Kidd, S.E. AU - Hagen, F. AU - Tscharke, R.L. AU - Huynh, M. AU - Bartlett, M. AU - Fyfe, M. AU - MacDougall, L. AU - Boekhout, T. DO - 10.1016/j.ijid.2019.08.021 IS - 6 KW - 1 KW - 2 KW - 3 KW - AIDS KW - Amplified fragment length polymorphism (AFLP) KW - Cryptococcosis KW - Cryptococcus gattii KW - Cryptococcus neoformans KW - Epidemiology KW - Fungaemia KW - Genomics KW - HAART KW - IRIS KW - Immunology KW - Inflammation KW - Kidney transplant recipients KW - Mating type KW - PCR fingerprinting KW - Pathogen KW - Restriction fragment length polymorphism (RFLP) KW - Taxonomy KW - Yeast KW - aids KW - and KW - and radiological entities during KW - article KW - cryptococcal pneumonia KW - cryptococcus neoformans KW - environment of the disease KW - epiblast KW - fluconazole KW - gfp fusion KW - histone h2b- KW - how to diagnose and KW - icm KW - infection and the KW - know KW - lineage specification KW - live imaging KW - mouse blastocyst KW - objectives KW - pdgfr α KW - pneumonia KW - primitive endoderm KW - readers should KW - recognize the different clinical KW - treat pulmonary cryptococcosis KW - understand cryptococcus neoformans pulmonary KW - upon completion of this PB - Elsevier PY - 2013 SN - 6176321972 SP - S4 EP - S12 TI - A rare genotype of Cryptococcus gattii caused the cryptococcosis outbreak on Vancouver Island (British Columbia, Canada) T2 - Aids UR - https://doi.org/10.1016/j.ijid.2019.08.021 UR - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3624763/pdf/nihms412728.pdf UR - http://dx.doi.org/10.1016/S1130-1406(08)70019-6 VL - 8 ER - TY - JOUR AB - Cryptococcosis is a potentially lethal disease of humans/animals caused by Cryptococcus neoformans and Cryptococcus gattii . Distinction between the two species is based on phenotypic and genotypic characteristics. Recently, it was proposed that C. neoformans be divided into two species and C. gattii into five species based on a phylogenetic analysis of 115 isolates. While this proposal adds to the knowledge about the genetic diversity and population structure of cryptococcosis agents, the published genotypes of 2,606 strains have already revealed more genetic diversity than is encompassed by seven species. Naming every clade as a separate species at this juncture will lead to continuing nomenclatural instability. In the absence of biological differences between clades and no consensus about how DNA sequence alone can delineate a species, we recommend using “ Cryptococcus neoformans species complex” and “ C. gattii species complex” as a practical intermediate step, rather than creating more species. This strategy recognizes genetic diversity without creating confusion. AU - Kwon-Chung, Kyung J. AU - Bennett, John E. AU - Wickes, Brian L. AU - Meyer, Wieland AU - Cuomo, Christina A. AU - Wollenburg, Kurt R. AU - Bicanic, Tihana A. AU - Castañeda, Elizabeth AU - Chang, Yun C. AU - Chen, Jianghan AU - Cogliati, Massimo AU - Dromer, Françoise AU - Ellis, David AU - Filler, Scott G. AU - Fisher, Matthew C. AU - Harrison, Thomas S. AU - Holland, Steven M. AU - Kohno, Shigeru AU - Kronstad, James W. AU - Lazera, Marcia AU - Levitz, Stuart M. AU - Lionakis, Michail S. AU - May, Robin C. AU - Ngamskulrongroj, Popchai AU - Pappas, Peter G. AU - Perfect, John R. AU - Rickerts, Volker AU - Sorrell, Tania C. AU - Walsh, Thomas J. AU - Williamson, Peter R. AU - Xu, Jianping AU - Zelazny, Adrian M. AU - Casadevall, Arturo DO - 10.1128/msphere.00357-16 IS - 1 PY - 2017 SP - 1 EP - 7 TI - The Case for Adopting the “Species Complex” Nomenclature for the Etiologic Agents of Cryptococcosis T2 - mSphere VL - 2 ER - TY - JOUR AB - Introducción. Con el fin de conocer la situación de la criptococosis en Colombia se ha llevado a cabo una encuesta nacional. El presente estudio analiza la información recogida de 1997 a 2005. Materiales y métodos. Se utilizó el formato de encuesta de la Confederación Europea de Micología Médica. Resultados. Se recibieron 931 encuestas de 76 centros. Se identificaron 891 (95,7%) casos de neurocriptococosis, 27 (2,9%) de formas pulmonares, cinco (0,5%) de lesiones cutáneas, dos (0,2%) de ganglionares, dos (0,2%) de úlceras orofaríngeas y un caso (0,1%) de cada una de las siguientes formas clínicas: peritonitis, lesión hepática, celulitis de los miembros inferiores e infección de las vías urinarias. El 82,7% fueron hombres con predominio de los adultos jóvenes. Sin embargo, se reportaron 25 (2,7%) niños. La infección por el virus de la inmunodeficiencia humana se encontró en el 78,1% de los casos. La incidencia promedio anual de criptococosis en la población general fue de 2,4 casos x106, pero en los pacientes con sida se elevó a 3,0 casos x 103. Las manifestaciones clínicas más frecuentes fueron: cefalea (85,2%), náuseas y vómito (59,1%), fiebre (59%), cambios mentales (46,2%) y signos meníngeos (33,4%). El examen directo de líquido cefalorraquídeo fue positivo en el 92,8% de los casos y el hongo se recuperó en el 90,3%. El antígeno capsular tuvo una positividad del 98,9% en el líquido cefalorraquídeo y del 93,7% en el suero. De 788 aislamientos remitidos, 95,9% fueron Cryptococcus neoformans var. grubii serotipo A, 0,3%, var. neoformans serotipo D, 3,3%, C. gattii serotipo B y 0,5%, C. gattii serotipo C. La mayoría de los pacientes fueron tratados inicialmente con anfotericina B. Conclusión: La criptococosis es una enfermedad cuya incidencia aumentó con la pandemia del VIH y constituye un marcador centinela de sida en Colombia. AU - Lizarazo, Jairo AU - Linares, Melva AU - De Bedout, Catalina AU - Restrepo, Ángela AU - Agudelo, Clara Inés AU - Castañeda, Elizabeth AU - Estudio de la Criptococosis, Grupo Colombiano para el DO - 10.7705/biomedica.v27i1.236 IS - 1 KW - adquirida KW - colombia KW - criptococosis KW - cryptococcus neoformans KW - epidemiological survey on cryptococcosis KW - in KW - morbilidad KW - mortalidad KW - of the clinical and KW - results of nine years KW - síndrome de inmunodeficiencia PY - 2007 SP - 94 EP - 94 TI - Estudio clínico y epidemiológico de la criptococosis en Colombia: resultados de nueve años de la encuesta nacional, 1997-2005 T2 - Biomédica VL - 27 ER - TY - JOUR AB - Infections due to rare Cryptococcus species (other than C. neoformans species complex, C. gattii species complex, C. albidus or C. laurentii) are barely reported. The aim of this work is to present a comprehensive literature review of all the papers describing infections due to these species referenced in the main databases (PubMed/MEDLINE, ScienceDirect, Scopus, and Google Scholar). Clinical and epidemiological data together with laboratory findings (identification and antifungal susceptibility) of each isolate were analyzed. Fifty-eight cryptococosis due to rare species were described in 46 papers between 1934-2018. These reports included 16 rare Cryptococcus spp. that were generally associated with nervous system infections and fungemias. Some species are non-capsulated and are not able to grow at 37 °C. Few species were identified by commercially available methods, making internal transcriber spacer (ITS) and D1/D2 regions sequencing mandatory. The most potent antifungal was amphotericin B (although some species showed high MIC values). The studied strains showed high MICs values to 5-fluorocytosine (all >64 µg/mL), echinocandins (all >8 µg/mL), and fluconazole (>80% of the MICs >4 µg/mL). Due to the scarcity of the data and the absence of guidelines for the treatment of these infections, this review could be informative and could help in the diagnosis and treatment of these infections. AU - Morales-López, Soraya E. AU - Garcia-Effron, Guillermo DO - 10.3390/jof7040279 IS - 4 KW - Cryptococcosis KW - Cryptococcus sp. KW - Rare yeast PY - 2021 SP - 1 EP - 20 TI - Infections due to rare Cryptococcus species. A literature review T2 - Journal of Fungi VL - 7 ER - TY - JOUR AB - Introduction: A survey on cryptococcosis is being conducted regularly in Colombia since 1997. We present hereby the results corresponding to patients diagnosed from 2006 to 2010. Objective: To analyze the data obtained during this period. Materials and methods: Retrospective analysis of the corresponding surveys. Results: A total of 526 surveys originating from 72% of the Colombian political divisions were received during the 5-year period. Most patients (76.6%) were males and 74.9% were 21-50 years old. The most prevalent risk factor was HIV infection (83.5%) with cryptococcosis defining AIDS in 23% of the cases. In the general population the estimated mean annual incidence rate for cryptococcosis was 2.4×106 inhabitants while in AIDS patients this rate rose to 3.3×103. In 474 surveys stating clinical features, most frequent complaints were headache 84.5%, fever 63.4%, nausea and vomiting 57.5%, mental alterations 46.3%, meningeal signs 33.0%, cough 26.4% and visual alterations 24.5%. Neurocryptococcosis was recorded in 81.8% of the cases. Laboratory diagnosis was based on direct examination, culture and latex in 29.3% cases. From 413 Cryptococcus isolates analyzed, 95.6% were identified as C. neoformans var. grubii, 1% C. neoformans var. neoformans, and 3.4% C. gattii. Treatment was reported for 71.6% of the cases with amphotericin B alone or in combination with fluconazole prescribed in 28%. Conclusions: Surveys done through passive surveillance continue to be sentinel markers for HIV infection and represent a systematic approach to the study of opportunistic problems regularly afflicting AIDS patients since cryptococcosis requires no compulsory notification in Colombia. AU - Escandón, Patricia AU - de Bedout, Catalina AU - Lizarazo, Jairo AU - Agudelo, Clara Inés AU - Tobón, Ángela AU - Bello, Solmara AU - Restrepo, Ángela AU - Castañeda, Elizabeth DO - 10.7705/biomedica.v32i3.707 IS - 3 KW - Acquired immunodeficiency Syndrome KW - Colombia. KW - Cryptococcosis KW - Cryptococcus gattii KW - Cryptococcus neoformans KW - Morbidity KW - Mortality PY - 2012 SP - 386 EP - 398 TI - Cryptococcosis in colombia: Results of the national surveillance program for the years 2006-2010 T2 - Biomedica VL - 32 ER - TY - JOUR AB - Cryptococcus neoformans and Cryptococcus gattii are the two etiologic agents of crypto coccosis. They belong to the phylum Basidiomycota and can be readily distinguished from other pathogenic yeasts such as Candida by the presence of a polysaccharide capsule,... formation of melanin, and urease activity, which all function as virulence determinants.| Infection proceeds via inhalation and subsequent dissemination to the central nervous system to cause meningoencephalitis. The most common risk for cryptococcosis caused c" by C. neoformans is AIDS, whereas infections caused by C. gattii are more often reported in immunocompetent patients with undefined risk than in the immunocompromised. There havebeen many chapters, reviews, and books written on C. neoformans. Thetopics wefocus on in this article include species description, pathogenesis, life cycle, capsule, and stress response, which serve to highlight the specializations in virulence that have occurred in this U | uniqueencapsulated melanin-formingyeast that causes global deathsestimated at more tan 600,000 annually. AU - Kwon-Chung, Kyung J. AU - Fraser, James A. AU - Doering, T. Ámara L. AU - Wang, Zhuo A. AU - Janbon, Guilhem AU - Idnurm, Alexander AU - Bahn, Yong Sun DO - 10.1101/cshperspect.a019760 IS - 7 PY - 2015 SP - 1 EP - 27 TI - Cryptococcus neoformans and Cryptococcus gattii, the etiologic agents of cryptococcosis T2 - Cold Spring Harbor Perspectives in Medicine VL - 4 ER - TY - JOUR AB - The passive and voluntary surveillance of cryptococcosis in Colombia since 1997 has seen an increasing participating rate, revealing its importance to both in immunosuppressed and immunocompetent people. The present work details the national data gathered in 1997–2016, through a retrospective analysis of the information collected in the survey. From a total of 1974 cases reported, an overall incidence of 0.23 cases per 100,000 people was found. This incidence rose to 1.1 cases per 1000 people in the Acquired Immunodeficiency Syndrome (AIDS) population. Cryptococcosis was most common in male young adults (26–40 years), with a male:female ratio of 3.9:1 in the general population and 5.4:1 in Human Immunodeficiency Virus (HIV) patients. Culture was the most common form of diagnosis in 96.3% of cases, recovering C. neoformans species in 87.5% and C. gattii in 3.1% of samples. VNI was the most prevalent (96.1%) molecular type, while VGII predominated in C. gattii isolates (54.3%). Early mortality was reported as the outcome in 47.5% of patients. Cryptococcosis remains an important opportunistic disease in Colombia and is gaining status as a primary pathogen in apparently immunocompetent patients. Our findings show the importance of including cryptococcosis as a notifiable disease, which will allow for improving opportune diagnosis and treatment, resulting in better patient outcomes. AU - Escandón, Patricia AU - Lizarazo, Jairo AU - Agudelo, Clara Inés AU - Castañeda, Elizabeth DO - 10.3390/jof4010032 IS - 1 KW - Colombia KW - Cryptococcosis KW - Epidemiology PY - 2018 TI - Cryptococcosis in Colombia: Compilation and analysis of data from laboratory-based surveillance T2 - Journal of Fungi VL - 4 ER - TY - JOUR AB - Background Cryptococcus is the most common cause of meningitis in adults living with HIV in sub-Saharan Africa. Global burden estimates are crucial to guide prevention strategies and to determine treatment needs, and we aimed to provide an updated estimate of global incidence of HIV-associated cryptococcal disease. Methods We used 2014 Joint UN Programme on HIV and AIDS estimates of adults (aged >15 years) with HIV and antiretroviral therapy (ART) coverage. Estimates of CD4 less than 100 cells per μL, virological failure incidence, and loss to follow-up were from published multinational cohorts in low-income and middle-income countries. We calculated those at risk for cryptococcal infection, specifically those with CD4 less than 100 cells/μL not on ART, and those with CD4 less than 100 cells per μL on ART but lost to follow-up or with virological failure. Cryptococcal antigenaemia prevalence by country was derived from 46 studies globally. Based on cryptococcal antigenaemia prevalence in each country and region, we estimated the annual numbers of people who are developing and dying from cryptococcal meningitis. Findings We estimated an average global cryptococcal antigenaemia prevalence of 6·0% (95% CI 5·8–6·2) among people with a CD4 cell count of less than 100 cells per μL, with 278 000 (95% CI 195 500–340 600) people positive for cryptococcal antigen globally and 223 100 (95% CI 150 600–282 400) incident cases of cryptococcal meningitis globally in 2014. Sub-Saharan Africa accounted for 73% of the estimated cryptococcal meningitis cases in 2014 (162 500 cases [95% CI 113 600–193 900]). Annual global deaths from cryptococcal meningitis were estimated at 181 100 (95% CI 119 400–234 300), with 135 900 (75%; [95% CI 93 900–163 900]) deaths in sub-Saharan Africa. Globally, cryptococcal meningitis was responsible for 15% of AIDS-related deaths (95% CI 10–19). Interpretation Our analysis highlights the substantial ongoing burden of HIV-associated cryptococcal disease, primarily in sub-Saharan Africa. Cryptococcal meningitis is a metric of HIV treatment programme failure; timely HIV testing and rapid linkage to care remain an urgent priority. Funding None. AU - Rajasingham, Radha AU - Smith, Rachel M AU - Park, Benjamin J AU - Jarvis, Joseph DO - 10.1016/S1473-3099(17)30243-8.Global IS - 10 KW - asian americans KW - depression KW - osteoarthritis KW - pain KW - quantitative sensory testing PY - 2017 SP - 139 EP - 148 TI - Global burden of disease of HIV-associated cryptococcal meningitis: an updated analysis T2 - Physiology & behavior VL - 176 ER - TY - JOUR AB - The taxonomy of Filobasidiella neoformans Kwon-Chung and F. bacillispora Kwon-Chung and their anamorphs were reinvestigated. Although the cross between the type cultures of the two species failed to produce viable basidio-spores, another pair of isolates did yield viable basidiospores. The segregation of phenotypic markers among the tetrads isolated from this interspecific cross proved that meiosis had occurred. On the basis of other previously known differences and the present genetic study, the two species are now considered to be two varieties of the species, F. neoformans. The anamorph of F. neoformans var. neoformans grew well at 37°C in vitro and produced fatal infection in mice while that of F. neoformans var. bacillispora grew poorly at 37°C and failed to produce fatal infection in mice. Cryptococcus bacillisporus Kwon-Chung et Bennett is regarded as a synonym of C. neoformans var. gattii Vanbreuseghem et Takashio. © 1982 H. Veenman & Zonen B.V. AU - Kwon-Chung, K. J. AU - Bennett, J. E. AU - Rhodes, J. C. DO - 10.1007/BF00399484 IS - 1 PY - 1982 SP - 25 EP - 38 TI - Taxonomic studies on Filobasidiella species and their anamorphs T2 - Antonie van Leeuwenhoek VL - 48 ER - TY - JOUR AU - Goldman, David AU - Khine, Hni AU - Abadi, Jacob AU - Lindenberg, DAnia AU - Pirofski, Liise-anne AU - Niang, Ramata AU - Casadevall, Arturo IS - 3 PY - 2017 SP - 2015 EP - 2016 TI - Serologic Evidence for Cryptococcus neoformans Infection in Early Childhood T2 - Pediatrics VL - 23 ER - TY - JOUR AB - Cryptococcosis is a potentially lethal disease of humans/animals caused by Cryptococcus neoformans and Cryptococcus gattii . Distinction between the two species is based on phenotypic and genotypic characteristics. Recently, it was proposed that C. neoformans be divided into two species and C. gattii into five species based on a phylogenetic analysis of 115 isolates. While this proposal adds to the knowledge about the genetic diversity and population structure of cryptococcosis agents, the published genotypes of 2,606 strains have already revealed more genetic diversity than is encompassed by seven species. Naming every clade as a separate species at this juncture will lead to continuing nomenclatural instability. In the absence of biological differences between clades and no consensus about how DNA sequence alone can delineate a species, we recommend using “ Cryptococcus neoformans species complex” and “ C. gattii species complex” as a practical intermediate step, rather than creating more species. This strategy recognizes genetic diversity without creating confusion. AU - Kwon-Chung, Kyung J. AU - Bennett, John E. AU - Wickes, Brian L. AU - Meyer, Wieland AU - Cuomo, Christina A. AU - Wollenburg, Kurt R. AU - Bicanic, Tihana A. AU - Castañeda, Elizabeth AU - Chang, Yun C. AU - Chen, Jianghan AU - Cogliati, Massimo AU - Dromer, Françoise AU - Ellis, David AU - Filler, Scott G. AU - Fisher, Matthew C. AU - Harrison, Thomas S. AU - Holland, Steven M. AU - Kohno, Shigeru AU - Kronstad, James W. AU - Lazera, Marcia AU - Levitz, Stuart M. AU - Lionakis, Michail S. AU - May, Robin C. AU - Ngamskulrongroj, Popchai AU - Pappas, Peter G. AU - Perfect, John R. AU - Rickerts, Volker AU - Sorrell, Tania C. AU - Walsh, Thomas J. AU - Williamson, Peter R. AU - Xu, Jianping AU - Zelazny, Adrian M. AU - Casadevall, Arturo DO - 10.1128/msphere.00357-16 IS - 1 PY - 2017 SP - 1 EP - 7 TI - The Case for Adopting the “Species Complex” Nomenclature for the Etiologic Agents of Cryptococcosis T2 - mSphere VL - 2 ER - TY - JOUR AB - En micología, el cultivo es la mejor manera de realizar el diagnóstico definitivo de una mico- sis. Muchos tipos de medios han sido desarrollados ymodificados para tal fin, utilizando las pro- piedades bioquímicas de los hongos para reconocerlos. Los medios más comunes son Sabouraud, agar Malta, agar maíz, agar Papa-dextrosa, y agar Staib. Este último ha sido ampliamente usado para la identificación de levaduras del género Cryptococcus y en otros hongos. El objetivo de este estudio fue demostrar la utilidad del agar Staib y de unmedio de Staib modificado, sin creatinina, en el aislamiento e identificación de hongos patógenos. Cuarenta y seis aislados de Cryptococcus neoformans más un control fueron identificados por criterios morfológicos y bioquímicos, usando la prueba de ureasa (agar urea de Christensen) y cultivo en medio Sablac. Las cepas fueron transfe- ridas a placas de agar Staib estandar y de agar Staib sin creatinina. Las placas fueron incubadas a temperatura ambiente (26-28°C) durante una semana y luego fueron evaluadas las características morfológicas de las colonias y producción de fenoloxidasa. En 43 (91.5%) de las cepas estudiadas, se observó producción de fenoloxidasa (presencia de colonias marrones) tanto en el agar estandar como en el agar sin creatinina. Conclusión: el agar Staib sin creatinina es un medio excelente para la identificación de C. neoformans, con las ventajas de un bajo costo y fácil preparación. AU - Nardelli, Vanessa AU - Perez, Celina AU - Mata-Essayag, Sofia AU - Colella, M Teresa AU - Roselló, Arantza AU - Hartung, Claudia AU - Landaeta, M Eugenia AU - Olaizola, Carolina AU - Magaldi, Sylvia IS - 2 KW - Agar Staib KW - Cryptococcus neoformans KW - Guizotia abyssinica KW - creatinina PY - 2005 SP - 102 EP - 108 TI - Identification of Cryptococcus neoformans isolates using Staib agar without creatinine T2 - Kasmera VL - 33 ER - TY - JOUR AU - Kwon-Chung, K. J. DO - 10.1080/00275514.1976.12019972 IS - 4 PY - 1976 SP - 943 EP - 946 TI - A new species of Filobasidiella, the sexual state of Cryptococcus neoformans B and C serotypes. T2 - Mycologia VL - 68 ER - TY - JOUR AB - Cryptococcus neoformans is an opportunistic fungal pathogen that could cause infection in patients with immunodeficiency and healthy patients. The AIDS epidemic has shown the importance of studying the ecology and epidemiology of this fungus. The aim of this investigation was to determine if there was a relationship between the environmental distribution of the different varieties of C. neoformans and the thermal floors in two transects located in department of Cundinamarca, in Colombia. For the isolation and identification of the yeast, conventional phenotypic methods were used and it was determined the population density (CFU/g of sample) and which was the variety of greater prevalence in each altitudinal rank. A total of 765 samples, from 26 municipalities were collected; of these 146 corresponded to pigeon droppings (Columba livia), 437 to eucalyptus detritus (Eucalyptus camaldulensis and related species) and 182 to detritus of almond trees (Terminalia cattapa). C. neoformans was isolated from 46% of the studied municipalities, in both transects and the thermal floor: warn, temperate and cold. The results indicated that the greater frequency of positive isolations came from the last thermal floor. The population density in pigeon excrements oscillated between 50 and 9.2 × 106, in eucalyptus between 50 and 1 × 107 and almendros was 50 CFU/g. Of 104 positive isolations 31 % were serotype A, 59% serotype B and 10% serotype C; 96% of the isolates grew to 37 °C and all showed capsule. In conclusion, C. neoformans prevails in the three habitats studied but it showed a predilection for the cold thermal floor; the population densities did not allow defining a standard pattern of occurrence. © 2005 Revista Iberoamericana de Micologia. AU - Quintero, Elizabeth AU - Castañeda, Elizabeth AU - Ruiz, Alejandro DO - 10.1016/S1130-1406(05)70015-2 IS - 2 KW - Cryptococcus neoformans KW - Population density KW - Thermal floors PY - 2005 SP - 93 EP - 98 TI - Distribución ambiental de Cryptococcus neoformans en el departamento de Cundinamarca-Colombia T2 - Revista Iberoamericana de Micologia VL - 22 ER - TY - JOUR AU - Kwon-chung, Author K J IS - 6 PY - 1975 SP - 1197 EP - 1200 TI - A New Genus , Filobasidiella , the Perfect State of Cryptococcus neoformans T2 - Mycologia VL - 67 ER - TY - JOUR AB - Phylogenetic analysis of 11 genetic loci and results from many genotyping studies revealed significant genetic diversity with the pathogenic Cryptococcus gattii/. Cryptococcus neoformans species complex. Genealogical concordance, coalescence-based, and species tree approaches supported the presence of distinct and concordant lineages within the complex. Consequently, we propose to recognize the current C. neoformans var. grubii and C. neoformans var. neoformans as separate species, and five species within C. gattii. The type strain of C. neoformans CBS132 represents a serotype AD hybrid and is replaced. The newly delimited species differ in aspects of pathogenicity, prevalence for patient groups, as well as biochemical and physiological aspects, such as susceptibility to antifungals. MALDI-TOF mass spectrometry readily distinguishes the newly recognized species. AU - Hagen, Ferry AU - Khayhan, Kantarawee AU - Theelen, Bart AU - Kolecka, Anna AU - Polacheck, Itzhack AU - Sionov, Edward AU - Falk, Rama AU - Parnmen, Sittiporn AU - Lumbsch, H. Thorsten AU - Boekhout, Teun DO - 10.1016/j.fgb.2015.02.009 KW - Cryptic species KW - Cryptococcus gattii KW - Cryptococcus neoformans KW - Pathogen KW - Taxonomy KW - Yeast PB - Elsevier Inc. PY - 2015 SP - 16 EP - 48 TI - Recognition of seven species in the Cryptococcus gattii/Cryptococcus neoformans species complex T2 - Fungal Genetics and Biology VL - 78 ER - TY - JOUR AB - Cryptococcus neoformans, the agent of cryptococcosis, had been considered a homogeneous species until 1949 when the existence of four serotypes was revealed based on the antigenic properties of its polysaccharide capsule. Such heterogeneity of the species, however, remained obscure until the two morphologically distinct teleomorphs of C. neoformans were discovered during the mid 1970s. The teleomorph Filobasidiella neoformans was found to be produced by strains of serotype A and D, and Filobasidiella bacillispora was found to be produced by strains of serotype B and C. Ensuing studies revealed numerous differences between the anamorphs of the two Filobasidiella species with regard to their ecology, epidemiology, pathobiology, biochemistry and genetics. At present, the etiologic agent of cryptococcosis is classified into two species, C. neoformans (serotypes A and D) and Cryptococcus gattii (serotypes B and C). Intraspecific genetic diversity has also been revealed as more genotyping methods have been applied for each serotype. As a result, the number of scientifically valid species within C. neoformans has become a controversial issue because of the differing opinions among taxonomists as to the appropriate definition of a species. There are three major species concepts that govern classification of organisms: phenetic (morphologic, phenotypic), biologic (interbreeding) and cladistic (evolutionary, phylogenetic). Classification of the two C. neoformans species has been based on the phenetic as well as the biologic species concept, which is also supported by the cladistic species concept. In this paper, we review and attest to the validity of the current two-species system in light of the three major species concepts. © 2006 Federation of European Microbiological Societies. AU - Kwon-Chung, Kyung J. AU - Varma, Ashok DO - 10.1111/j.1567-1364.2006.00088.x IS - 4 KW - Cryptococcus gattii KW - Cryptococcus neoformans KW - Species concept PY - 2006 SP - 574 EP - 587 TI - Do major species concepts support one, two or more species within Cryptococcus neoformans? T2 - FEMS Yeast Research VL - 6 ER - TY - JOUR AB - Introduction: Cryptococcosis is the second most frequent cause of opportunistic infections in human immunodeficiency virus (HIV) patients in Colombia. We aimed to determine the prevalence of cryptococcosis in the Colombian department of Atlántico. Methods: An active search for cryptococcosis cases was conducted between 2015 and 2017 in health institutions by distributing surveys to clinicians and characterizing samples phenotypically and genotypically. Results: Thirty-eight cryptococcosis cases were identified (81.6% men, 76.3% HIV patients). The calculated annual prevalence was 5.08/1 million inhabitants. Cryptococcus neoformans var. grubii VNI was isolated in 34 cases. Conclusions: These results provide the basis for passive surveillance of cryptococcosis. AU - Noguera, María Clara AU - Escandón, Patricia AU - Arévalo, Merle AU - García, Yina AU - Suárez, Luz Estela AU - Castañeda, Elizabeth DO - 10.1590/0037-8682-0194-2018 IS - November 2018 KW - Active epidemiological search KW - Annual prevalence KW - Colombia KW - Cryptococcosis KW - Cryptococcus gattii KW - Cryptococcus neoformans PY - 2019 SN - 0037868201942 SP - 0 EP - 2 TI - Prevalence of cryptococcosis in Atlántico, department of Colombia assessed with an active epidemiological search T2 - Revista da Sociedade Brasileira de Medicina Tropical VL - 52 ER - TY - JOUR AB - Cryptococcosis is a potentially fatal opportunistic mycosis that affects the lungs and central nervous system. It has been suggested that certain strains of C. neoformans/C. gattii may have the potential to be more virulent according to the molecular type. This study aims to investigate the association between virulence in the G. mellonella model and genotypic diversity of Colombian clinical and environmental isolates of C. neoformans/C. gattii. A total of 33 clinical and 12 environmental isolates were selected according to their geographical origin and sequence types (STs). Pathogenicity was determined using the G. mellonella model, and the cell and capsular size before and after inoculation was determined. For C. neoformans, virulence in G. mellonella revealed that death occurred on average on day 6 (p < 0.05) and that ST5C, 6C, 25C and 71C were the most virulent. In C. gattii, death occurred at 7.3 days (p < 0.05), and ST47C, 58C, 75A and 106C were the most virulent. Capsular size increased for both species after passage in G. mellonella. In conclusion, the pathogenicity of Cryptococcus strains in the G. mellonella invertebrate model is independent of molecular type or pathogenicity factor, even within the same ST, but it is possible to find variable degrees of pathogenicity. AU - Velez, Norida AU - Alvarado, Maira AU - Parra-Giraldo, Claudia Marcela AU - Sánchez-Quitian, Zilpa Adriana AU - Escandón, Patricia AU - Castañeda, Elizabeth DO - 10.3390/jof4030082 IS - 3 KW - Colombia KW - Cryptococcus gattii KW - Cryptococcus neoformans KW - Galleria mellonella KW - Multi locus sequence typing (MLST) KW - Pathogenicity PY - 2018 TI - Genotypic diversity is independent of pathogenicity in Colombian strains of Cryptococcus neoformans and Cryptococcus gattii in Galleria mellonella T2 - Journal of Fungi VL - 4 ER - TY - JOUR AB - Cryptococcus neoformans, an opportunistic fungal pathogen ubiquitously present in the environment, causes cryptococcal meningitis (CM) mainly in immunocompromised patients, such as AIDS patients. We aimed to identify disease-associated cryptococcal protein antigens targeted by the human humoral immune response. Therefore, we used sera from Colombian CM patients, with or without HIV infection, and from healthy individuals living in the same region. Serological analysis revealed increased titers of anti-cryptococcal IgG in HIV-negative CM patients, but not HIV-positive CM patients, compared to healthy controls. In contrast, titers of anti-cryptococcal IgM were not affected by CM. Furthermore, we detected pre-existing IgG and IgM antibodies even in sera from healthy individuals. The observed induction of anti-cryptococcal IgG but not IgM during CM was supported by analysis of sera from C. neoformans-infected mice. Stronger increase in IgG was found in wild type mice with high lung fungal burden compared to IL-4Rα-deficient mice showing low lung fungal burden. To identify the proteins targeted by human anti-cryptococcal IgG antibodies, we applied a quantitative 2D immunoproteome approach identifying cryptococcal protein spots preferentially recognized by sera from CM patients or healthy individuals followed by mass spectrometry analysis. Twenty-three cryptococcal proteins were recombinantly expressed and confirmed to be immunoreactive with human sera. Fourteen of them were newly described as immunoreactive proteins. Twelve proteins were classified as disease-associated antigens, based on significantly stronger immunoreactivity with sera from CM patients compared to healthy individuals. The proteins identified in our screen significantly expand the pool of cryptococcal proteins with potential for (i) development of novel anti-cryptococcal agents based on implications in cryptococcal virulence or survival, or (ii) development of an anti-cryptococcal vaccine, as several candidates lack homology to human proteins and are localized extracellularly. Furthermore, this study defines pre-existing anti-cryptococcal immunoreactivity in healthy individuals at a molecular level, identifying target antigens recognized by sera from healthy control persons. AU - Gressler, A. Elisabeth AU - Volke, Daniela AU - Firacative, Carolina AU - Schnabel, Christiane L. AU - Müller, Uwe AU - Krizsan, Andor AU - Schulze-Richter, Bianca AU - Brock, Matthias AU - Brombacher, Frank AU - Escandón, Patricia AU - Hoffmann, Ralf AU - Alber, Gottfried DO - 10.3389/fimmu.2021.709695 IS - July KW - Cryptococcus neoformans KW - cryptococcal meningitis KW - fungal infection KW - human samples KW - humoral immunity KW - immunoproteomics PY - 2021 SP - 1 EP - 19 TI - Identification of Disease-Associated Cryptococcal Proteins Reactive With Serum IgG From Cryptococcal Meningitis Patients T2 - Frontiers in Immunology VL - 12 ER - TY - JOUR AB - Cryptococcus neoformans is an opportunistic fungal pathogen that could cause infection in patients with immunodeficiency and healthy patients. The AIDS epidemic has shown the importance of studying the ecology and epidemiology of this fungus. The aim of this investigation was to determine if there was a relationship between the environmental distribution of the different varieties of C. neoformans and the thermal floors in two transects located in department of Cundinamarca, in Colombia. For the isolation and identification of the yeast, conventional phenotypic methods were used and it was determined the population density (CFU/g of sample) and which was the variety of greater prevalence in each altitudinal rank. A total of 765 samples, from 26 municipalities were collected; of these 146 corresponded to pigeon droppings (Columba livia), 437 to eucalyptus detritus (Eucalyptus camaldulensis and related species) and 182 to detritus of almond trees (Terminalia cattapa). C. neoformans was isolated from 46% of the studied municipalities, in both transects and the thermal floor: warn, temperate and cold. The results indicated that the greater frequency of positive isolations came from the last thermal floor. The population density in pigeon excrements oscillated between 50 and 9.2 × 106, in eucalyptus between 50 and 1 × 107 and almendros was 50 CFU/g. Of 104 positive isolations 31 % were serotype A, 59% serotype B and 10% serotype C; 96% of the isolates grew to 37 °C and all showed capsule. In conclusion, C. neoformans prevails in the three habitats studied but it showed a predilection for the cold thermal floor; the population densities did not allow defining a standard pattern of occurrence. © 2005 Revista Iberoamericana de Micologia. AU - Goldman, David L. AU - Khine, Hnin AU - Abadi, Jacob AU - Lindenberg, Dabia J. AU - Pirofski, Liise-anne AU - Niang, Ramata DO - 10.1016/j.fgb.2015.02.009 IS - 1 KW - Agar Staib KW - Colombia KW - Cryptic species KW - Cryptococcosis KW - Cryptococcus gattii KW - Cryptococcus neoformans KW - Epidemiology KW - Guizotia abyssinica KW - Pathogen KW - Population density KW - Species concept KW - Taxonomy KW - Thermal floors KW - Yeast KW - asian americans KW - creatinina KW - depression KW - osteoarthritis KW - pain KW - quantitative sensory testing PB - Elsevier Inc. PY - 2015 SP - 574 EP - 587 TI - Serologic Evidence for Cryptococcus neoformans Infection in Early Childhood T2 - Mycologia VL - 4 ER - TY - JOUR AU - Corti, Marcelo AU - Boschi, Analía AU - Villafañe, Maria F. AU - Messina, Fernando AU - Negroni, Ricardo AU - Arechavala, Alicia AU - Franze, Osvaldo DO - 10.5216/rpt.v43i4.33618 IS - 4 KW - criptococosis KW - cryptococcus KW - histoplasma capsulatum KW - histoplasmosis KW - sida PY - 2015 SP - 500 EP - 506 TI - Criptococosis E Histoplasmosis Diseminadas Y Simultáneas Como Primera Manifestación De Sida T2 - Revista de Patologia Tropical VL - 43 ER - TY - JOUR AU - Tello, Mercedes AU - Gutiérrez, Ericson AU - Béjar, Vilma AU - Galarza, Carlos AU - Ramos, Willy AU - Ortega-loayza, Alex G IS - 2 KW - criptococosis KW - cryptococcus gattii KW - cryptococcus neoformans PY - 2013 SP - 147 EP - 153 TI - Criptococosis VL - 19 ER - TY - JOUR AB - Using a class-specific enzyme immunoassay IgG and IgA anticryptococcal antibody was measured in 400 serum specimens at 1 week to 11·7 years after diagnosis from 43 immunocompetent subjects with confirmed active cryptococcosis. The prevalence of IgG was 86% at diagnosis, rose to 100% by 2 weeks and remained high thereafter. IgA prevalence was 71% at diagnosis, rose to 75% at 2 weeks and then fell over 2 years. IgG and IgA prevalence in paediatric controls was 5% and 0%, respectively. Mean antibody levels showed the same pattern and neither levels nor prevalence were influenced by age, sex or site of infection. Patients with the variety gattii infection had a greater antibody response than those with the variety neoformans which was significant for IgA. Specific anticryptococcal antibody was regularly present in conjunction with cryptococcal antigen at diagnosis. IgG persists but IgA falls over 1-2 years. The assay described may be a useful tool to study the antibody response and seroepidemiology of infection with C. neoformans. © 1996 Informa UK Ltd All rights reserved. AU - Speed, B. R. AU - Kaldor, J. AU - Cairns, B. AU - Pegorer, M. DO - 10.1080/02681219680000311 IS - 3 KW - C. neoformans KW - antibody KW - cryptococcosis KW - variety PY - 1996 SP - 187 EP - 193 TI - Serum antibody response to active infection with Cryptococcus neoformans and its varieties in immunocompetent subjects T2 - Medical Mycology VL - 34 ER - TY - JOUR AB - We determined total and Cryptococcus neoformans glucuronoxylomannan (GXM)-reactive antibody repertoires of human immunodeficiency virus (HIV)-infected and HIV-uninfected Ugandans in a retrospective, case-control study of participants in a randomized controlled trial of pneumococcal vaccination. The study included 192 adults: 48 who subsequently developed cryptococcal meningitis (CM); (HIV+ CM+); 2 individuals who matched them in CD4+ T-cell level, stage of HIV disease, and age but did not develop CM (HIV+ CM-); and 48 HIV-uninfected individuals. Total serum immunoglobulin concentrations and titers of immunoglobulin M (IgM), IgG, and IgA to GXM, pneumococcal polysaccharides, and antibodies expressing certain VH3 idiotypes were determined with banked sera obtained before the development of cryptococcosis for HIV + CM+ subjects. The results showed that HIV-infected subjects had significantly lower levels of IgM to GXM but higher levels of total immunoglobulin and IgG and IgA to GXM than those of HIV-uninfected subjects. HIV-infected subjects with a history of pneumonia had higher levels, and those with a history of herpes zoster had lower levels of GXM-binding antibodies than subjects with no history of either disease. Minimal to no cross-reactivity was demonstrated between antibodies to GXM and polysaccharides in a pneumococcal vaccine. No significant differences between the antibody repertoires of HIV + CM+ and HIV+ CM- subjects were identified, but among subjects without a history of pneumonia, there was a trend towards lower VH3-positive antibody levels among HIV+ CM+ than among HIV+ CM- subjects. Our findings demonstrate an association between previous infectious diseases and differences in the total and GXM-reactive antibody repertoires of HIV-infected subjects and suggest the question of whether certain microbes modulate subsequent antibody responses to GXM deserves further study. Copyright © 2005, American Society for Microbiology. All Rights Reserved. AU - Subramaniam, Krishanthi AU - French, Neil AU - Pirofski, Liise Anne DO - 10.1128/CDLI.12.10.1168-1176.2005 IS - 10 PY - 2005 SP - 1168 EP - 1176 TI - Cryptococcus neoformans-reactive and total immunoglobulin profiles of human immunodeficiency virus-infected and uninfected Ugandans T2 - Clinical and Diagnostic Laboratory Immunology VL - 12 ER - TY - JOUR AB - Objective: Cryptococcal meningitis is one of the most important HIV-related opportunistic infections, especially in the developing world. In order to help develop global strategies and priorities for prevention and treatment, it is important to estimate the burden of cryptococcal meningitis. Design: Global burden of disease estimation using published studies. Methods: We used the median incidence rate of available studies in a geographic region to estimate the region-specific cryptococcal meningitis incidence; this was multiplied by the 2007 United Nations Programme on HIV/AIDS HIV population estimate for each region to estimate cryptococcal meningitis cases. To estimate deaths, we assumed a 9% 3-month case-fatality rate among high-income regions, a 55% rate among low-income and middle-income regions, and a 70% rate in sub-Saharan Africa, based on studies published in these areas and expert opinion. Results: Published incidence ranged from 0.04 to 12% per year among persons with HIV. Sub-Saharan Africa had the highest yearly burden estimate (median incidence 3.2%, 720000 cases; range, 144000-1.3 million). Median incidence was lowest in Western and Central Europe and Oceania (≤0.1% each). Globally, approximately 957 900 cases (range, 371 700-1 544 000) of cryptococcal meningitis occur each year, resulting in 624700 deaths (range, 125000-1 124900) by 3 months after infection. Conclusion: This study, the first attempt to estimate the global burden of cryptococcal meningitis, finds the number of cases and deaths to be very high, with most occurring in sub-Saharan Africa. Further work is needed to better define the scope of the problem and track the epidemiology of this infection, in order to prioritize prevention, diagnosis, and treatment strategies. © 2009 Wolters Kluwer Health|Lippincott Williams & Wilkins. AU - Park, Benjamin J. AU - Wannemuehler, Kathleen A. AU - Marston, Barbara J. AU - Govender, Nelesh AU - Pappas, Peter G. AU - Chiller, Tom M. DO - 10.1097/QAD.0b013e328322ffac IS - 4 KW - AIDS KW - Burden KW - Cryptococcal meningitis KW - Cryptococcus KW - Epidemiology KW - HIV PY - 2009 SP - 525 EP - 530 TI - Estimation of the current global burden of cryptococcal meningitis among persons living with HIV/AIDS T2 - Aids VL - 23 ER - TY - JOUR AU - Laurenson, IF AU - Lalloo, DG AU - Naraqi, S. AU - Seaton, RA AU - Trevett, AJ AU - Matuka, A. AU - y Kevau, IH IS - August PY - 1997 SP - 437 EP - 440 TI - Cryptococcus neoformans in Papua New Guinea: a common pathogen but an elusive source. T2 - Medical Mycology VL - 35(6) ER - TY - JOUR AU - López-Martínez, R AU - Córdova-Martínez, E AU - Bazán-Mora, E AU - Mondragón-Ordóñez, MA AU - Ángeles-Morales, V AU - García-Zaldívar, P AU - Castañón-Olivares, LR IS - 2 KW - Criptococosis KW - Cryptococcus KW - Frecuencia KW - Serotipos PY - 2014 SP - 125 EP - 128 TI - Frecuencia de serotipos de Cryptococcus neoformans/C. gattii en México T2 - Rev Latioam Patol Clin Med Lab VL - 61 ER - TY - JOUR AB - Active, population-based surveillance for invasive pneumococcal infections in Greater Vancouver (population 473,000 children) demonstrated a rapid, substantial decrease in incidence rates for children 6-23 months old with routine infant vaccination. In the subpopulation with best case ascertainment disease rates for 6-23 month olds decreased 84.6% (92.5% for vaccine serotypes). © 2007 Lippincott Williams & Wilkins, Inc. AU - Davis, J AU - Zheng, WY AU - Glatman-Freedman A DO - 10.1097/INF.0b013e31803c56df IS - 6 KW - Childhood KW - Immunization KW - Streptococcus pneumoniae PY - 2007 SP - 540 EP - 542 TI - Serologic evidence for regional differences in pediatric cryptococcal infection T2 - Pediatric Infectious Disease Journal VL - 26 ER - TY - JOUR AB - Bruton's tyrosine kinase (Btk) is a signaling molecule that plays important roles in B-1 B cell development and innate myeloid cell functions and has recently been identified as a target for therapy of B cell lymphomas. We examined the contribution of B-1 B cells to resistance to Cryptococcus neoformans infection by utilizing X-linked immunodeficient (XID) mice (CBACaHN-XID), which possess a mutation in Btk. XID mice had significantly higher brain fungal burdens than the controls 6 weeks after infection with C. neoformans strain 52D (CN52D); however, consistent with the propensity for greater virulence of C. neoformans strain H99 (CNH99), CNH99-infected XID mice had higher lung and brain fungal burdens than the controls 3 weeks after infection. Further studies in a chronic CN52D model revealed markedly lower levels of total and C. neoformans-specific serum IgM in XID mice than in the control mice 1 and 6 weeks after infection. Alveolar macrophage phagocytosis was markedly impaired in CN52D-infected XID mice compared to the controls, with XID mice exhibiting a disorganized lung inflammatory pattern in which Gomori silver staining revealed significantly more enlarged, extracellular C. neoformans cells than the controls. Adoptive transfer of B-1 B cells to XID mice restored peritoneal B-1 B cells but did not restore IgM levels to those of the controls and had no effect on the brain fungal burden at 6 weeks. Taken together, our data support the hypothesis that IgM promotes fungal containment in the lungs by enhancing C. neoformans phagocytosis and restricting C. neoformans enlargement. However, peritoneal B-1 B cells are insufficient to reconstitute a protective effect in the lungs. IMPORTANCE Cryptococcus neoformans is a fungal pathogen that causes an estimated 600,000 deaths per year. Most infections occur in individuals who are immunocompromised, with the majority of cases occurring in those with HIV/AIDS, but healthy individuals also develop disease. ImmunoglobulinM(IgM) has been linked to resistance to disease in humans and mice. In this article, we found that X-linked immunodeficient (XID) mice, which have markedly reduced levels of IgM, were unable to contain Cryptococcus in the lungs. This was associated with reduced yeast uptake by macrophages, an aberrant tissue inflammatory response, an enlargement of the yeast cells in the lungs, and fungal dissemination to the brain. Since XID mice have a mutation in the Bruton's tyrosine kinase (Btk) gene, our data suggest that treatments aimed at blocking the function of Btk could pose a higher risk for cryptococcosis. © 2013 Szymczak et al. AU - Szymczak, Wendy A. AU - Davis, Michael J. AU - Lundy, Steven K. AU - Dufaud, Chad AU - Olszewski, Michal AU - Pirofski, Liise Anne DO - 10.1128/mBio.00265-13 IS - 4 PY - 2013 SP - 17 EP - 20 TI - X-linked immunodeficient mice exhibit enhanced susceptibility to Cryptococcus neoformans infection T2 - mBio VL - 4 ER - TY - JOUR AB - Objective. Identify and molecularly characterize Cryptococcus isolates potentially pathogenic to humans from environmental and clinical samples collected in the city of Cúcuta. Materials and methods. We collected 1300 samples from 446 trees belonging to ten different species in ten public spaces in Cúcuta. We also obtained clinical isolates of Cryptococcus neoformans collected between June 2016 and July 2017. Samples were cultivated in Guizottia abysinica seed medium, and then were identified biochemically and characterized by Fingerprinting PCR and RFLP of URA5 gene. Results. C. neoformans displayed an environmental prevalence of 4.3% (19 positive individuals) and C. gattii 0.2% (1 positive individual); this yields a total of 20 Cryptococcus-positive trees and 21 isolates. The Santander park registered 47.6% of the global prevalence (10/21 isolates), followed by La Victoria Park with 23.8% (5/21 isolates). One C. gattii isolate was collected from a Ficus benjamina tree located in Mercedes Ábrego park. Genotypic analysis revealed the presence of C. neoformans var. grubii VNI in 85.7% of environmental isolates as well as 100% of clinical isolates. VNII and VGII molecular types represented 9.5% and 4.8% of environmental isolates respectively. Conclusiones. The longitudinal sampling of previously reported environmental niches of the fungus reveals its presence and suggests that a permanent surveillance in both environment and patients is required, especially in endemic zones of the city. AU - Angarita Sanchez, Asbleide AU - Cardenas Sierra, Denny AU - Parra Giraldo, Claudia AU - Diaz Carbajal, Claudia AU - Escandon Hernandez, Patricia IS - 0 KW - colombia KW - criptococosis KW - decs KW - fuentes KW - genotipo KW - hábitat KW - mesh KW - prevalencia PY - 2019 SP - 7137 EP - 7144 TI - Recuperación de Cryptococcus neoformans y C. gattii ambientales y su asociación con aislados clínicos en Cúcuta, Colombia T2 - Revista MVZ Córdoba VL - 24 (1) ER - TY - JOUR AB - Cryptococcosis is a fungal disease affecting more than one million people per year worldwide. The main etiological agents of cryptococcosis are the two sibling species Cryptococcus neoformans and Cryptococcus gattii that present numerous differences in geographical distribution, ecological niches, epidemiology, pathobiology, clinical presentation and molecular characters. Genotyping of the two Cryptococcus species at subspecies level supplies relevant information to understand how this fungus has spread worldwide, the nature of its population structure, and how it evolved to be a deadly pathogen. At present, nine major molecular types have been recognized: VNI, VNII, VNB, VNIII, and VNIV among C. neoformans isolates, and VGI, VGII, VGIII, and VGIV among C. gattii isolates. In this paper all the information available in the literature concerning the isolation of the two Cryptococcus species has been collected and analyzed on the basis of their geographical origin, source of isolation, level of identification, species, and molecular type. A detailed analysis of the geographical distribution of the major molecular types in each continent has been described and represented on thematic maps. This study represents a useful tool to start new epidemiological surveys on the basis of the present knowledge. AU - Cogliati, Massimo DO - 10.1155/2013/675213 IS - serotype D PY - 2013 SP - 1 EP - 23 TI - Global Molecular Epidemiology of Cryptococcus neoformans and Cryptococcus gattii : An Atlas of the Molecular Types T2 - Scientifica VL - 2013 ER - TY - JOUR AB - Cryptococcus neoformans, an encapsulated yeast, is a common cause of life-threatening meningoencephalitis in immunosuppressed patients. We previously observed that administration of a monoclonal antibody (MAb) to the capsular polysaccharide to mice with pulmonary infection prolonged survival and enhanced granulomatous inflammation without reducing lung CFU. To understand the mechanism of MAb action, we studied leukocyte recruitment and cytokine profiles in lungs of A/JCr mice. B lymphocytes were the predominant cell type in lung infiltrates, comprising 15 to 30% of the leukocytes. Despite alterations in histological appearance, fluorescence-activated cell sorter analysis revealed no significant difference in total numbers of lung leukocytes in MAb-treated mice and controls. Differences in the immune response to C. neoformans between MAb-treated mice and controls included (i) an increase in the percentage of granulocytes among lung leukocytes on day 14, (ii) higher macrophage surface expression of CD86 on day 28, (iii) larger amounts of IL-10 in lung homogenates at day 7, (iv) a trend toward smaller amounts of gamma interferon mRNA and protein on day 7, and (v) a smaller increase in the levels of interleukin-4 mRNA and protein on day 7. Hence, the immune responses to C. neoformans infection in the presence and absence of specific antibody were qualitatively similar, and antibody administration was associated with several subtle quantitative differences in immune response parameters that could translate into enhanced survival. MAb may function partly by down-regulating the inflammatory response and reducing host damage. Our findings demonstrate unexpected complexity in the interaction between specific MAb and other components of the host immune response. AU - Feldmesser, Marta AU - Mednick, Aron AU - Casadevall, Arturo DO - 10.1128/IAI.70.3.1571-1580.2002 IS - 3 PY - 2002 SP - 1571 EP - 1580 TI - Antibody-mediated protection in murine Cryptococcus neoformans infection is associated with pleotrophic effects on cytokine and leukocyte responses T2 - Infection and Immunity VL - 70 ER - TY - GEN AB - Ketidakseimbangan beban pada suatu sistem distribusi tenaga listrik selalu terjadi dan penyebab ketidakseimbangan itu karena tidak meratanya beban-beban pada pelanggan jaringan tegangan rendah. Penelitian ini dilakukan pada transformator pada hari rabu , 3 Juli 2019 mulai pukul 10.00 WIB sampai pukul 20.00 WIB. Dengan menggunakan rumus perhitungan ketidakseimbangan beban dan rugi daya maka diperoleh hasil ketidakseimbagan beban berkisar 3,3% - 33,6% dan rugi daya berkisar 7,15 W - 41,85 W. Dapat disimpulkan bahwa semakin besar arus netral yang timbul pada saluran netral akibat ketidakseimbangan beban maka semakin besar rugi daya yang dihasilkan. Untuk mengurangi rugi daya tersebut perlu dilakukan pemerataan beban pada tiap phasa. Kata AU - Avellaneda Figueroa, Luis Alberto AU - Contreras Niños, Elizabeth PY - 2019 SP - 1 EP - 9 TI - Evaluacion de la patogenicidad de Cryptococcus neoformans serotipo VNI en Galleria mellonella in vitro en el 2018 VL - 3 ER - TY - JOUR AB - Cryptococcosis is an opportunistic disease caused by the fungus Cryptococcus neoformans and Cryptococcus gattii. It starts as a pulmonary infection that can spread to other organs, such as the brain, leading to the most serious occurrence of the disease, meningoencephalitis. The humoral response has already been described in limiting the progression of cryptococcosis where the B-1 cell seems to be responsible for producing natural IgM antibodies, crucial for combating fungal infections. The role of the B-1 cell in C. neoformans infection has been initially described, however the role of the humoral response of B-1 cells has not yet been evaluated during C. gattii infections. In the present study we tried to unravel this issue using XID mice, a murine model deficient in the Btk protein which compromises the development of B-1 lymphocytes. We use the XID mice compared to BALB/c mice that are sufficient for the B-1 population during C. gattii infection. Our model of chronic lung infection revealed that XID mice, unlike the sufficient group of B-1, had early mortality with significant weight loss, in addition to reduced levels of IgM and IgG specific to GXM isolated from the capsule of C. neoformans. In addition to this, we observed an increased fungal load in the blood and in the brain. We described an increase in the capsular size of C. gattii and the predominant presence of cytokines with a Th2 profile was also observed in these animals. Thus, the present study strongly points to a higher susceptibility of the XID mouse to C. gattii, which suggests that the presence of B-1 cells and anti-GXM antibodies is fundamental during the control of infection by C. gattii. AU - Diniz-Lima, Israel AU - da Rosa, Pablo Rodrigo AU - da Silva-Junior, Elias Barbosa AU - Guimarães-de-Oliveira, Joyce Cristina AU - de Freitas, Elisangela Oliveira AU - de Oliveira Nascimento, Danielle AU - Morrot, Alexandre AU - Nimrichter, Leonardo AU - Previato, Jose Osvaldo AU - Mendonça-Previato, Lucia AU - Freire-de-Lima, Leonardo AU - Decote-Ricardo, Debora AU - Freire-de-Lima, Celio Geraldo DO - 10.1038/s41598-021-97041-9 IS - 1 PB - Nature Publishing Group UK PY - 2021 SN - 0123456789 SP - 1 EP - 11 TI - X-linked immunodeficient (XID) mice exhibit high susceptibility to Cryptococcus gattii infection T2 - Scientific Reports VL - 11 ER - TY - JOUR AB - To determine whether particular environmental, medical, or behavioral risk factors existed among Cryptcoccus gattii-infected persons compared with the general population, we conducted a sex-matched case-control study on a subset of case-patients in British Columbia (1999-2001). Exposures and underlying medical conditions among all case-patients (1999-2007) were also compared with results of provincial population-based surveys and studies. In case-control analyses, oral steroids (matched odds ratio [MOR] 8.11, 95% confidence interval [CI] 1.74-37.80), pneumonia (MOR 2.71, 95% CI 1.05-6.98), and other lung conditions (MOR 3.21, 95% CI 1.08-9.52) were associated with infection. In population comparisons, case-patients were more likely to be ≥50 years of age (p<0.001), current smokers (p<0.001), infected with HIV (p<0.001), or have a history of invasive cancer (p<0.001). Although C. gattii is commonly believed to infect persons with apparently healthy immune systems, several immunosuppressive and pulmonary conditions seem to be risk factors. AU - MacDougall, Laura AU - Fyfe, Murray AU - Romney, Marc AU - Starr, Mike AU - Galanis, Eleni DO - 10.3201/eid1702.101020 IS - 2 PY - 2011 SP - 193 EP - 199 TI - Risk factors for Cryptococcus gattii infection, British Columbia, Canada T2 - Emerging Infectious Diseases VL - 17 ER - TY - JOUR AB - Cryptococcosis is a global invasive mycosis associated with significant morbidity and mortality. These guidelines for its management have been built on the previous Infectious Diseases Society of America guidelines from 2000 and include new sections. There is a discussion of the management of cryptococcal meningoencephalitis in 3 risk groups: (1) human immunodeficiency virus (HIV)-infected individuals, (2) organ transplant recipients, and (3) non-HIV-infected and nontransplant hosts. There are specific recommendations for other unique risk populations, such as children, pregnant women, persons in resource-limited environments, and those with Cryptococcus gattii infection. Recommendations for management also include other sites of infection, including strategies for pulmonary cryptococcosis. Emphasis has been placed on potential complications in management of cryptococcal infection, including increased intracranial pressure, immune reconstitution inflammatory syndrome (IRIS), drug resistance, and cryptococcomas. Three key management principles have been articulated: (1) induction therapy for meningoencephalitis using fungicidal regimens, such as a polyene and flucytosine, followed by suppressive regimens using fluconazole; (2) importance of early recognition and treatment of increased intracranial pressure and/or IRIS; and (3) the use of lipid formulations of amphotericin B regimens in patients with renal impairment. Cryptococcosis remains a challenging management issue, with little new drug development or recent definitive studies. However, if the diagnosis is made early, if clinicians adhere to the basic principles of these guidelines, and if the underlying disease is controlled, then cryptococcosis can be managed successfully in the vast majority of patients. © 2010 by the Infectious Diseases Society of America. All rights reserved. AU - Perfect, John R. AU - Dismukes, William E. AU - Dromer, Francoise AU - Goldman, David L. AU - Graybill, John R. AU - Hamill, Richard J. AU - Harrison, Thomas S. AU - Larsen, Robert A. AU - Lortholary, Olivier AU - Nguyen, Minh Hong AU - Pappas, Peter G. AU - Powderly, William G. AU - Singh, Nina AU - Sobel, Jack D. AU - Sorrell, Tania C. DO - 10.1086/649858 IS - 3 PY - 2010 SP - 291 EP - 322 TI - Clinical practice guidelines for the management of cryptococcal disease: 2010 update by the infectious diseases society of America T2 - Clinical Infectious Diseases VL - 50 ER - TY - JOUR AU - Gómez Ruíz, Ginneth Paola PY - 2018 SP - 63 EP - 63 TI - Evaluación de la susceptibilidad antifúngica, caracterización proteómica y virulencia de aislamientos clínicos colombianos en UR - https://repository.javeriana.edu.co/handle/10554/35526 ER - TY - JOUR AB - Cryptococcus neoformans is an encapsulated yeast that is pathogenic for humans. The capsule is a major virulence factor composed mainly of glucuronoxylomannan (GXM) and two minor constituents, galactoxylomannan, and mannoprotein (MP). A hallmark of disseminated cryptococcosis is the presence of high concentrations of GXM in body fluids of infected hosts. GXM provides a critical negative signal for T cell activation and neutrophil migration at the site of the inflammatory process. There is also strong evidence that MP promotes critical events associated with protective responses such as delayed type hypersensitivity and presumably a T helper type 1 response. The contrasting roles of GXM and MP in regulation of the immune response to C. neoformans offer a promising template for a successful approach to intervention, by scavenging GXM to attenuate its negative signals, while preserving the positive effects of MP. AU - Vecchiarelli, A. DO - 10.1080/714030973 IS - 6 KW - Cryptococcus neoformans KW - Galactoxylomannan KW - Glucuronoxylomannan KW - Mannoprotein PY - 2000 SP - 407 EP - 417 TI - Immunoregulation by capsular components of Cryptococcus neoformans T2 - Medical Mycology VL - 38 ER - TY - JOUR AB - Summary This chapter reviews the evidence of disease after acute infection and reactivation of latent infection, considering the newer epidemiological and serological studies and the older anatomical evidence. Cryptococcal meningitis was diagnosed in an HIV-infected patient who helped dismantle an aviary, and another patient had pigeons nesting in the ceiling above his desk. Cryptococcal infection occurs in children as demonstrated by the existence of antibodies to Cryptococcus neoformans in children. Primary pulmonary cryptococcosis may be asymptomatic or confused with viral infections frequently observed during childhood. The high incidence of disease reported in the Vancouver Island outbreak may not be the norm, even though it appears from epidemiological studies that C. neoformans has a greater potential for reactivation of infection leading to disease than C. gattii. The overwhelming majority of individuals with persistent/latent infection would remain asymptomatic as long as they retained an intact immune system. In murine inhalational models acute pulmonary infection with C. neoformans is rapidly followed by the appearance of cryptococci both free and within macrophages in the lymphoid sinuses of hilar (draining) lymph nodes. The best animal model available for the study of latency and reactivation is experimental rat pulmonary cryptococcosis. AU - Dromer, Françoise AU - Casadevall, Arturo AU - Perfect, John AU - Sorrell, Tania DO - 10.1128/9781555816858.ch31 PY - 2014 SP - 429 EP - 439 TI - Cryptococcus neoformans : Latency and Disease T2 - Cryptococcus ER - TY - JOUR AB - The present study dissected the role of a Th2 bias in pathogenesis of Cryptococcus neoformans H99 infection by comparing inhalational H99 infections in wild-type BALB/c and IL-4/IL-13 double knockout mice. H99-infected wild-type mice showed all major hallmarks of Th2 but not Th1/Th17 immunity in the lungs and lung-associated lymph nodes. In contrast, the IL-4/13-/- mice developed robust hallmarks of Th1 and Th17 but not Th2 polarization. The IL-4/IL-13 deletion prevented pulmonary eosinophilia, goblet cell metaplasia in the airways and resulted in elevated serum IgE, and a switch from alternative to classical activation of macrophages. The development of a robust Th1/Th17 response and classical activation of macrophages resulted in significant containment of H99 in the lungs of IL-4/13-/- mice compared with unopposed growth of H99 in the lungs of wild-type mice. However, IL-4/13 -/- mice showed only 1-week longer survival compared with wild-type mice. The comparison of brain and spleen cryptococcal loads at weeks 2, 3, and 4 postinfection revealed that the systemic dissemination in IL-4/13-/- mice occurred with an approximate 1-week delay but subsequently progressed with similar rate as in the wild-type mice. Furthermore, wild-type and IL-4/13 -/- mice developed equivalently severe meningitis/encephalitis at the time of death. These data indicate that the Th2 immune bias is a crucial mechanism for pulmonary virulence of H99, whereas other mechanisms are largely responsible for its central nervous system tropism and systemic dissemination. Copyright © American Society for Investigative Pathology. AU - Zhang, Yanmei AU - Wang, Fuyuan AU - Tompkins, Kristin C. AU - McNamara, Andrew AU - Jain, Aditya V. AU - Moore, Bethany B. AU - Toews, Galen B. AU - Huffnagle, Gary B. AU - Olszewski, Michal A. DO - 10.2353/ajpath.2009.090530 IS - 6 PB - American Society for Investigative Pathology PY - 2009 SP - 2489 EP - 2500 TI - Robust Th1 and Th17 immunity supports pulmonary clearance but cannot prevent systemic dissemination of highly virulent Cryptococcus neoformans H99 T2 - American Journal of Pathology UR - http://dx.doi.org/10.2353/ajpath.2009.090530 VL - 175 ER - TY - JOUR AB - La criptococosis es una entidad infecciosa que afecta con frecuencia el Sistema Nervioso Central. Después de la aparición del virus de inmunodefi ciencia humana/síndrome de inmu- nodefi ciencia adquirida, se ha convertido en una de las principales causas de neuroinfección en este grupo poblacional, cursando con alta morbilidad y mortalidad. Objetivos: Describir las características clínicas, factores predisponentes y hallazgos más frecuentes en la diferentes ayudas diagnosticas de esta infección usualmente oportunista en la población a estudio. Materiales y Métodos: Estudio descriptivo, retrospectivo donde se revisaron historias clínicas de pacientes con diagnóstico de crip- tococosis meníngea con cultivo positivo, ingresados al Hospital Universitario San José en el periodo comprendido entre 1998 y 2012. Se evaluó género, edad, antecedentes patológicos y factores predis- ponentes, así como presentación clínica, hallazgos imagenológicos y microbiológicos a nivel cerebral y del LCR respectivamente. Resultados: se incluyeron 12 casos en el estudio. La edad promedio encontrada fue de 39 años, el factor predisponente más frecuente es el VIH/SIDA con un 58.3%. En la presentación clínica el síntoma más frecuente fue la cefalea con un 91.7% y la presencia de signos meníngeos con un 33.3%. El diagnóstico fue con cultivo positivo para Criptococo neoformans en el 91.7%, mientras que en el 8,3% restante se aisló Criptococo neoformans variedad gattii. De los pacientes ingresados al estudio el 66.7% sobrevivió y el 33.3% restante había fallecido al término del estudio. Conclusiones: La criptococosis es una de las principales causas de compromiso meníngeo y los más afectados por este germen oportunista son los pacientes con VIH/SIDA. AU - Omar, Tomas AU - Bastidas, Zamora AU - Karina, Diana AU - Reyes, Agredo AU - Silvio, John AU - Salazar, Agredo IS - 2 KW - Brain cryptococcosis KW - Central Nervous System KW - Criptococosis cerebral KW - Meningitis. KW - meningitis KW - sistema nervioso central PY - 2013 SP - 104 EP - 122 TI - Criptococosis cerebral Análisis de 12 casos y revisión de la literatura T2 - Medicina VL - 35 ER - TY - JOUR AB - The immune reconstitution inflammatory syndrome (IRIS) is an uncommon but serious complication that increases the morbi-mortality of some patients whose immune status begins to recover following immunosuppressant withdrawal, therefore responding to a previously acquired opportunistic infection. Such response is excessive and worsens the symptoms of the infection, leading to a severe and paradoxical deterioration of clinical status despite appropriate ongoing therapy for the infection. We present the case of a 67-year-old female with immunosuppression following hepatorenal transplantation, who exhibited general deterioration with decrease in food intake, somnolence and headache. She was diagnosed with meningeal cryptococcosis and initiated antifungal treatment with an initial favorable response. Two months after the patient suffered a relapse of her symptoms after which added greater neurological involvement. The present case report identifies the differential diagnoses that should be taken into account in cases similar to the one presented by our patient, highlighting the importance of considering the IRIS. © 2011 Sociedad Neurológica Argentina. Published by Elsevier España, S.L. All rights reserved. AU - Pontello, Noelia AU - Gleichgerrcht, Ezequiel AU - Facundo, Manes AU - Sinay, Vladimiro DO - 10.1016/j.neuarg.2011.07.002 IS - 1 KW - Cryptococcosis KW - Hepatorenal transplantation KW - Immune reconstitution KW - Immune restoration KW - Meningeal cryptococcosis in transplant recipients, PY - 2012 SP - 31 EP - 34 TI - Criptococosis meníngea en inmunosuprimidos: rol del síndrome inflamatorio de reconstitución inmune T2 - Neurologia Argentina VL - 4 ER - TY - JOUR AB - La criptococosis es una micosis causada por dos hongos levaduriformes encapsulados del género Cryptoccoccus, ingresa al organismo por vía inhalatoria con diseminación al sistema nervioso central, su prevalencia es mayor en inmunodeprimidos por VIH SIDA. Presentamos el caso de un paciente masculino de 13 años de edad, VIH negativo, de la etnia Lenca, procedente de zona rural de Honduras, con historia de contacto prolongado con heces de paloma (Columba livia), quien se presentó con síndrome de hipertensión endocraneana. Tinta china de líquido cefalorraquídeo reportó levaduras encapsuladas compatibles con Cryptococcus neoformans spp confirmado por cultivo. Su único antecedente de inmunosupresión fue la desnutrición. Tuvo evolución favorable con la terapia combinada anfotericina b y fluconazol. AU - Trejo-Espino, A. Wilfredo AU - Ramírez-Izcoa, Alejandro AU - Alvarado-Rivera, Swany AU - Godoy-Mejía, Carlos AU - Valenzuela-Castillo, Renato DO - 10.35663/amp.2016.333.118 IS - 3 KW - 08 KW - 2016 KW - 22 KW - anfotericina b KW - cryptococcus neoformans KW - decs bireme KW - desnutrición KW - fuente KW - meningoencefalitis KW - micosis KW - recibido PY - 2016 SP - 232 EP - 232 TI - Meningoencefalitis por Cryptococcus neoformans en adolescente con desnutrición T2 - Acta Medica Peruana VL - 33 ER - TY - JOUR AB - Antibodies reactive with the cryptococcal polysaccharide glucuronoxylomannan (GXM) are present in sera from both human immunodeficiency virus (HIV)-uninfected and -infected adults. However, the prevalence of these antibodies in US children is unknown. An antigen-capture ELISA was used to determine the presence, serotype specificity, isotype, and IgG subclass distribution of antibodies to GXM in sera from 27 HIV-uninfected and 34 HIV-infected children. The children were of similar age and socioeconomic background. IgG and IgM to GXM were present in sera from all children, although HIV-uninfected children had significantly higher titers. HIV-uninfected children had IgG1 and IgG2 to GXM and significantly greater IgG2 than in HIV-infected children. These findings of type-specific antibodies to GXM in early childhood suggest that exposure to or subclinical infection with Cryptococcus neoformans may be an early childhood event. AU - Abadi, Jacobo AU - Pirofski, Liise Anne DO - 10.1086/314953 IS - 3 PY - 1999 SP - 915 EP - 919 TI - Antibodies reactive with the cryptococcal capsular polysaccharide glucuronoxylomannan are present in sera from children with and without human immunodeficiency virus infection T2 - Journal of Infectious Diseases VL - 180 ER - TY - JOUR AB - Only two decades ago antibodies to fungi were thought to have little or no role in protection against fungal diseases. However, subsequent research has provided convincing evidence that certain antibodies can modify the course of fungal infection to the benefit or detriment of the host. Hybridoma technology was the breakthrough that enabled the characterization of antibodies to fungi, illuminating some of the requirements for antibody efficacy. As discussed in this review, fungal-specific antibodies mediate protection through direct actions on fungal cells and through classical mechanisms such as phagocytosis and complement activation. Although mechanisms of antibody-mediated protection are often species-specific, numerous fungal antigens can be targeted to generate vaccines and therapeutic immunoglobulins. Furthermore, the study of antibody function against medically important fungi has provided fresh immunological insights into the complexity of humoral immunity that are likely to apply to other pathogens. © 2012 Elsevier Inc. AU - Casadevall, Arturo AU - Pirofski, Liise Anne DO - 10.1016/j.chom.2012.04.004 IS - 5 PY - 2012 SP - 447 EP - 456 TI - Immunoglobulins in defense, pathogenesis, and therapy of fungal diseases T2 - Cell Host and Microbe VL - 11 ER - TY - JOUR AB - Cryptococcus gattii traditionally infects immunocompetent hosts and causes devastating pulmonary or central nervous system disease. However, this infection rarely occurs in patients infected with HIV. We report 3 cases of HIV-associated C. gattii complex infections in the southeastern United States. Detection of C. gattii in HIV-infected patients in this region warrants increased awareness of this threat to ensure appropriate diagnosis and treatment to optimize patient outcomes. AU - Bruner, Kaylee T. AU - Franco-Paredes, Carlos AU - Henao-Martínez, Andrés F. AU - Steele, Gregory M. AU - Chastain, Daniel B. DO - 10.3201/eid2411.180787 IS - 11 PY - 2018 SP - 1998 EP - 2002 TI - Cryptococcus gattii complex infections in HIV-infected patients, southeastern United States T2 - Emerging Infectious Diseases VL - 24 ER - TY - JOUR AB - Cryptococcus gattii is a fungal pathogen that can cause life-threatening respiratory and disseminated infections in immune-competent and immune-suppressed individuals. Currently, there are no standardized vaccines against cryptococcosis in humans, underlying an urgent need for effective therapies and/or vaccines. In this study, we evaluated the efficacy of intranasal immunization with C. gattii cell wall associated (CW) and/or cytoplasmic (CP) protein preparations to induce protection against experimental pulmonary C. gattii infection in mice. BALB/c mice immunized with C. gattii CW and/or CP protein preparations exhibited a significant reduction in pulmonary fungal burden and prolonged survival following pulmonary challenge with C. gattii. Protection was associated with significantly increased pro-inflammatory and Th1-type cytokine recall responses, in vitro and increased C. gattii-specific antibody production in immunized mice challenged with C. gattii. A number of immunodominant proteins were identified following immunoblot analysis of C. gattii CW and CP protein preparations using sera from immunized mice. Immunization with a combined CW and CP protein preparation resulted in an early increase in pulmonary T cell infiltrates following challenge with C. gattii. Overall, our studies show that C. gattii CW and CP protein preparations contain antigens that may be included in a subunit vaccine to induce prolonged protection against pulmonary C. gattii infection. © 2014 Chaturvedi et al. AU - Chaturvedi, Ashok K. AU - Hameed, Rumanasma S. AU - Wozniak, Karen L. AU - Hole, Camaron R. AU - Wager, Chrissy M.Leopold AU - Weintraub, Susan T. AU - Lopez-Ribot, Jose L. AU - Wormley, Floyd L. DO - 10.1371/journal.pone.0104316 IS - 8 PY - 2014 TI - Vaccine-mediated immune responses to experimental pulmonary cryptococcus gattii infection in mice T2 - PLoS ONE VL - 9 ER - TY - JOUR AB - Over the past 40 years, rigorous examination of brain function, structure, and attending factors through multidisciplinary research has helped identify the substrates of alcohol-related damage in the brain. One main area of this research has focused on the neuropsychological sequelae of alcoholism, which has resulted in the description of a pattern of sparing and impairment that provided an essential understanding of the functional deficits as well as of spared capabilities that could be useful in recovery. These studies have elucidated the component processes of memory, problem solving, and cognitive control, as well as visuospatial, and motor processes and their interactions with cognitive control processes. Another large area of research has focused on observable brain pathology, using increasingly sophisticated imaging technologies—progressing from pneumoencephalography to computed tomography, magnetic resonance imaging (MRI), diffusion tensor imaging, and functional MRI—that have enabled ever more detailed insight into brain structure and function. These advancements also have allowed analysis of the course of brain structural changes through periods of drinking, abstinence, and relapse. Keywords AU - Chaturvedi, Ashok K. AU - Weintraub, Susan T. AU - Lopez-Ribot, Jose L. AU - Jr., Floyd L. Wormley DO - 10.1002/pmic.201300213.Identification IS - 1 KW - epiblast KW - gfp fusion KW - histone h2b- KW - icm KW - lineage specification KW - live imaging KW - mouse blastocyst KW - pdgfr α KW - primitive endoderm PY - 2012 SN - 6176321972 SP - 1 EP - 7 TI - Identification and Characterization of Cryptococcus neoformans Protein T2 - Bone UR - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3624763/pdf/nihms412728.pdf VL - 23 ER - TY - JOUR AB - The prevalence and specificity of serum antibodies to Cryptococcus neoformans proteins was studied in mice and rats with experimental infection, in individuals with or without a history of potential laboratory exposure to C. neoformans, human immunodeficiency virus (HIV)-positive individuals who developed cryptococcosis, in matched samples from HIV-positive individuals who did not develop cryptococcosis, and in HIV-negative individuals. Rodents had little or no serum antibody reactive with C. neoformans proteins prior to infection. The intensity and specificity of the rodent antibody response were dependent on the species, the mouse strain, and the viability of the inoculum. All humans had serum antibodies reactive with C. neoformans proteins regardless of the potential exposure, the HIV infection status, or the subsequent development of cryptococcosis. Our results indicate (i) a high prevalence of antibodies reactive with C. neoformans proteins in the sera of rodents after cryptococcal infection and in humans with or without HIV infection; (ii) qualitative and quantitative differences in the antibody profiles of HIV-positive individuals; and (iii) similarities and differences between humans, mice, and rats with respect to the specificity of the antibodies reactive with C. neoformans proteins. The results are consistent with the view that C. neoformans infections are common in human populations, and the results have implications for the development of vaccination strategies against cryptococcosis. AU - Chen, Lin Chi AU - Goldman, David L. AU - Doering, Tamara L. AU - Pirofski, Liise Anne AU - Casadevall, Arturo DO - 10.1128/iai.67.5.2218-2224.1999 IS - 5 PY - 1999 SP - 2218 EP - 2224 TI - Antibody response to Cryptococcus neoformans proteins in rodents and humans T2 - Infection and Immunity VL - 67 ER - TY - JOUR AB - Background. Longer-term morbidity and outcomes of Cryptococcus gattii infection are not described. We analyzed clinical, microbiological, and outcome data in Australian patients followed for 12 months, to identify prognostic determinants.Methods.Culture-confirmed C. gattii cases from 2000 to 2007 were retrospectively evaluated. Clinical, microbiological, radiological, and outcome data were recorded at diagnosis and at 6 weeks, 6 months, and 12 months. Clinical and laboratory variables associated with mortality and with death and/or neurological sequelae were determined.Results.Annual C. gattii infection incidence was 0.61 per 106 population. Sixty-two of 86 (72) patients had no immunocompromise; 6 of 24 immunocompromised hosts had idiopathic CD4 lymphopenia, and 1 had human immunodeficiency virus/AIDS. Clinical and microbiological characteristics of infection were similar in immunocompromised and healthy hosts. Isolated lung, combined lung and central nervous system (CNS), and CNS only disease was reported in 12, 51 and 34 of the cases, respectively. Complications in CNS disease included raised intracranial pressure (42), hydrocephalus (30), neurological deficits (27; 6 developed during therapy) and immune reconstitutionlike syndrome (11). Geometric mean serum cryptococcal antigen (CRAG) titers in CNS disease were 563.9 (vs 149.3 in isolated lung infection). Patient immunocompromise was associated with increased mortality risk. An initial cerebrospinal fluid CRAG titer of ≥256 predicted death and/or neurological sequelae (P =. 05).Conclusions.Neurological C. gattii disease predominates in the Australian endemic setting. Lumbar puncture and cerebral imaging, especially if serum CRAG titers are ≥512, are essential. Long-term follow up is required to detect late neurological complications. Immune system evaluation is important because host immunocompromise is associated with reduced survival. © 2012 The Author. AU - Chen, Sharon C.A. AU - Slavin, Monica A. AU - Heath, Christopher H. AU - Geoffrey Playford, E. AU - Byth, Karen AU - Marriott, Deborah AU - Kidd, Sarah E. AU - Bak, Narin AU - Currie, Bart AU - Hajkowicz, Krispin AU - Korman, Tony M. AU - McBride, William J.H. AU - Meyer, Wieland AU - Murray, Ronan AU - Sorrell, Tania C. DO - 10.1093/cid/cis529 IS - 6 PY - 2012 SP - 789 EP - 798 TI - Clinical manifestations of cryptococcus gattii infection: Determinants of neurological sequelae and death T2 - Clinical Infectious Diseases VL - 55 ER - TY - JOUR AB - Hypergammaglobulinemia and defective humoral immunity are hallmarks of HIV-1 infection. Naive B cells have been recently suggested as the major source of hypergammaglobulinemia in chronic viral infections. We recently reported that HIV-1-infected patients carry low levels of memory B cells. Here we studied whether defects in the naive and memory B cells in HIV-1-infected patients translated into hypergammaglobulinemia and defective humoral immunity against specific antigens. Naive B cells from HIV-1-infected patients exhibited abnormal expression of the activation/differentiation markers CD70 and leukocyte-associated Ig-like receptor (LAIR-1). Activated naive B cells from patients showed a significant increase in the intracellular immunoglobulin G (IgG) content ex vivo and this activated phenotype correlated to hypergammaglobulinemia and to the ability of naive B cells from patients to secrete IgG in vitro. We analyzed the levels of antibodies to tetanus toxold, measles, and HIV-1 in relation to memory B cells and observed a significant reduction of antigen-specific antibodies in patients with low-memory B lymphocytes. Nevertheless, hypergammaglobulinemia and levels of polyspecific self-reactive antibodies were comparable in patients with normal and low memory B cells. We conclude that reduction of memory B lymphocytes in HIV-1 infection correlates with defective humoral immunity and that hyperactivated naive B cells may represent the source of abnormal IgG production in HIV-1 infection. Our results may be relevant to the design of HIV-1 therapeutical vaccines and to the clinical management of HIV-1-infected patients. © 2004 by The American Society of Hematology. AU - De Milito, Angelo AU - Nilsson, Anna AU - Titanji, Kehmia AU - Thorstensson, Rigmor AU - Reizenstein, Elisabet AU - Narita, Mitsuo AU - Grutzmeier, Sven AU - Sönnerborg, Anders AU - Chiodi, Francesca DO - 10.1182/blood-2003-07-2375 IS - 6 PY - 2004 SP - 2180 EP - 2186 TI - Mechanisms of hypergammaglobulinemia and impaired antigen-specific humoral immunity in HIV-1 infection T2 - Blood VL - 103 ER - TY - JOUR AB - The importance of humoral immunity for resistance to Cryptococcus neoformans is uncertain. A case-controlled study of the human antibody response to C. neoformans comparing the serum antibody profiles of human immunodeficiency virus (HIV)-infected persons who did (HIV+/CM+) or did not (HIV-infected controls) develop cryptococcal meningitis (CM) and HIV- uninfected persons with samples obtained from the Multicenter AIDS Cohort Study was performed. Total immunoglobulin concentrations were determined, and the specificity, isotype, and idiotype expression of antibodies to C. neoformans capsular glucuronoxylomannan were analyzed by ELISA. Compared with the HIV+/CM+ group, the HIV-infected control group had significantly lower levels of total IgM, IgA, and antibodies expressing a certain V(H)3 determinant. The HIV-infected control group manifested an increase in immunoglobulin levels with a decrease in CD4 lymphocytes. The findings suggest a possible association between reduced expression of certain immunoglobulin subsets and HIV-associated CM. AU - Fleuridor, R. AU - Lyles, R. H. AU - Pirofski, Liise Anne DO - 10.1086/315102 IS - 5 PY - 1999 SP - 1526 EP - 1535 TI - Quantitative and qualitative differences in the serum antibody profiles of human immunodeficiency virus-infected persons with and without Cryptococcus neoformans meningitis T2 - Journal of Infectious Diseases VL - 180 ER - TY - JOUR AB - Cryptococcosis is a life-threatening fungal infection caused by the encapsulated yeasts Cryptococcus neoformans and C. gattii, acquired from the environment. In Latin America, as occurring worldwide, C. neoformans causes more than 90% of the cases of cryptococcosis, affecting predominantly patients with HIV, while C. gattii generally affects otherwise healthy individuals. In this region, cryptococcal meningitis is the most common presentation, with amphotericin B and fluconazole being the antifungal drugs of choice. Avian droppings are the predominant environmental reservoir of C. neoformans, while C. gattii is associated with several arboreal species. Importantly, C. gattii has a high prevalence in Latin America and has been proposed to be the likely origin of some C. gattii populations in North America. Thus, in the recent years, significant progress has been made with the study of the basic biology and laboratory identification of cryptococcal strains, in understanding their ecology, population genetics, host-pathogen interactions, and the clinical epidemiology of this important mycosis in Latin America. AU - Firacative, Carolina AU - Lizarazo, Jairo AU - Illnait-Zaragozí, María Teresa AU - Castañeda, Elizabeth AU - Arechavala, Alicia AU - Córdoba, Susana AU - Mazza, Mariana AU - Taverna, Con Stanza AU - Isla, Guillermina AU - Chiapello, Laura AU - Vergara, Mario León Silva AU - Melhem, Marcia S.C. AU - Szeszs, Maria Walderez AU - Martins, Marilena Dos Anjos AU - Bonfietti, Lucas Xavier AU - de Oliveira, Rogério Antonio AU - de Oliveira, Lidiane AU - Santos, Dayane Christine Silva AU - Lazera, Marcia S. AU - Wanke, Bodo AU - Díaz, María Cristina AU - Escandón, Patricia AU - Noguera, María Clara AU - Andreu, Carlos Manuel Fernández AU - Castril­Lón, Laura AU - Bustamante, Beatriz AU - Dolande, Maribel AU - Ferrara, Giussepe DO - 10.1590/0074-02760170554 IS - 7 KW - Cryptococcosis KW - Cryptococcus gattii KW - Cryptococcus neoformans KW - Latin America PY - 2018 SP - 1 EP - 23 TI - The status of cryptococcosis in latin America T2 - Memorias do Instituto Oswaldo Cruz VL - 113 ER - TY - JOUR AB - The vast majority of infection with cryptococcal species occurs with Cryptococcus neoformans in the severely immunocompromised. A significant exception to this is the infections of those with apparently normal immune systems by Cryptococcus gattii. Susceptibility to cryptococcosis can be broadly categorised as a defect in adaptive immune responses, especially in T cell immunity. However, innate immune cells such as macrophages play a key role and are likely the primary effector cell in the killing and ultimate clearance of cryptococcal infection. In this review we discuss the current state of our understanding of how the immune system responds to cryptococcal infection in health and disease, with reference to the work communicated at the 9th International Conference on Cryptococcus and Cryptococcosis (ICCC9). We have focussed on cell mediated responses, particularly early in infection, but with the aim of presenting a broad overview of our understanding of immunity to cryptococcal infection, highlighting some recent advances and offering some perspectives on future directions. AU - Gibson, Josie F. AU - Johnston, Simon A. DO - 10.1016/j.fgb.2014.11.006 KW - Cryptococcosis KW - Cryptococcus gattii KW - Cryptococcus neoformans KW - Immunity KW - Macrophages KW - T cells PB - Elsevier Inc. PY - 2015 SP - 76 EP - 86 TI - Immunity to Cryptococcus neoformans and C. gattii during cryptococcosis T2 - Fungal Genetics and Biology UR - http://dx.doi.org/10.1016/j.fgb.2014.11.006 VL - 78 ER - TY - JOUR AB - Over the past 40 years, rigorous examination of brain function, structure, and attending factors through multidisciplinary research has helped identify the substrates of alcohol-related damage in the brain. One main area of this research has focused on the neuropsychological sequelae of alcoholism, which has resulted in the description of a pattern of sparing and impairment that provided an essential understanding of the functional deficits as well as of spared capabilities that could be useful in recovery. These studies have elucidated the component processes of memory, problem solving, and cognitive control, as well as visuospatial, and motor processes and their interactions with cognitive control processes. Another large area of research has focused on observable brain pathology, using increasingly sophisticated imaging technologies—progressing from pneumoencephalography to computed tomography, magnetic resonance imaging (MRI), diffusion tensor imaging, and functional MRI—that have enabled ever more detailed insight into brain structure and function. These advancements also have allowed analysis of the course of brain structural changes through periods of drinking, abstinence, and relapse. Keywords AU - Saha, Dolan Champa AU - Xess, Immaculata AU - Zeng, Wang Yong AU - Goldman, David L DO - 10.1080/13693780801961345.Antibody IS - 1 KW - epiblast KW - gfp fusion KW - histone h2b- KW - icm KW - lineage specification KW - live imaging KW - mouse blastocyst KW - pdgfr α KW - primitive endoderm PY - 2013 SN - 6176321972 SP - 1 EP - 7 TI - Antibody Responses to Cryptococcus neoformans in Indian Patients with Cryptococcosis T2 - Bone VL - 23 ER - TY - JOUR AB - Twenty-four sera from healthy donors, 18 from HIV-positive patients (< 200 CD4+/mm3) and 18 sera collected before and during cryptococcosis from HIV-positive patients were analysed for the presence of humoral response to C. neoformans mannoproteins. Our results show that samples from healthy subjects and from HIV-positive patients had one of three antibody response profiles: (i) presence of reactive antibodies against both 105 and 80 kilodalton mannoproteins; (ii) presence of reactive antibodies against one of the two mannoproteins; or (iii) absence of reactive antibodies. Importantly the percentage of unreactive sera increased 6-fold in HIV-positive patients and more than 10-fold in patients with cryptococcosis. In addition, in the latter patients no variation of humoral response before and during cryptococcosis was observed. These results suggest that HIV-positive patients show a marked difficulty in mounting or maintaining antibody response to mannoprotein and this could contribute to predisposition to cryptococcosis. AU - Pitzurra, L. AU - Perito, S. AU - Baldelli, F. AU - Bistoni, F. AU - Vecchiarelli, Anna DO - 10.1046/j.1365-2249.2003.02181.x IS - 1 KW - AIDS KW - Antibody response KW - C. neoformans KW - Humoral response KW - Mannoproteins PY - 2003 SP - 91 EP - 96 TI - Humoral response against Cryptococcus neoformans mannoprotein antigens in HIV-infected patients T2 - Clinical and Experimental Immunology VL - 133 ER - TY - JOUR AB - Melanins are associated with virulence in several important human pathogens, but little is known about the immune response to this ubiquitous biologic compound. We hypothesized that melanin produced by the fungus Cryptococcus neoformans was immunogenic. C. neoformans melanin was purified from melanized fungal cells and was used to immunize C57BL/6, BALB/c, and T cell-deficient (nude) BALB/c mice. The Ab response was evaluated by ELISA, immunofluorescence, and agglutination. The results demonstrate that melanin can be immunogenic, and the humoral immune response is T cell independent. Furthermore, the experiments demonstrate 1) a sensitive ELISA for the measurement of Ab to melanin, 2) that mice mount an intense Ab response to fungal melanin that includes Abs of IgM and IgG isotypes, 3) that melanins from different sources have cross-reactive epitopes, and 4) melanin in the cell wall of melanized yeast cells reacts with Abs raised to L-dopa C. neoformans melanin. The biologic significance of Ab to melanin remains to be determined, but the development of Ab suggests that this amorphous insoluble polymer can stimulate the immune system. The serologic techniques described here may prove useful for the evaluation of Ab responses to melanin in a variety of diseases. AU - Nosanchuk, J D AU - Rosas, A L AU - Casadevall, A IS - 12 PY - 1998 SP - 6026 EP - 31 TI - The antibody response to fungal melanin in mice. T2 - Journal of immunology (Baltimore, Md. : 1950) UR - http://www.ncbi.nlm.nih.gov/pubmed/9637518 VL - 160 ER - TY - JOUR AB - Background: To determine whether demographic and behavioral factors affect immunoglobulin regulation in HIV infection, we studied injection drug users, women, and minority ethnic and racial groups with and without HIV infection. Material/Methods: A prospective cross-sectional study of ambulatory persons with or at risk for HIV infection was conducted. We enrolled 48 injection drug users (IDUs) and 43 non-IDUs seropositive for HIV and 22 seronegative at-risk individuals in the Bronx, New York City. Sixteen HIV-seronegative, non-IDUs controls were also studied. Total serum immunoglobulin levels, IgG subclasses and lymphocyte phenotypes were measured. Results: Serum IgG, IgA, IgG 1 and IgG3 were increased in all stages of HIV infection controlling for injection drug use, gender, race and age (p≤0.05). Serum IgM levels were significantly decreased in HIV seropositives compared to HIV seronegatives (p<0.02). Two patterns of serum immunoglobulin level elevation were found in HIV infection: 1) IgG, IgG1 and IgG3 levels were elevated in early and advanced HIV infection; 2) IgA, IgG2 and IgG4 levels were elevated only in advanced HIV infection. IgG levels were increased in Blacks compared to Caucasians with HIV infection (p=0.01). Conclusions: Serum IgG, IgG1 and IgG3 levels are increased in early HIV infection, while serum IgA, IgG2, and IgG3 levels are increased only in advanced HIV infection. In contrast, serum IgM levels are decreased in HIV infection. HIV-seropositive Blacks have higher serum IgG levels than HIV-seropositive Caucasians. Further studies are necessary to determine the mechanism(s) underlying the different patterns of immunoglobulin elevation in HIV infection. © Med Sci Monit, 2006. AU - McGowan, Joseph P. AU - Shah, Sanjiv S. AU - Small, Catherine B. AU - Klein, Robert S. AU - Schnipper, Steven M. AU - Chang, C. J. AU - Rosenstreich, David L. IS - 1 KW - Human Immunodeficiency Virus KW - Immunoglobulin G subclasses KW - Injection drug use KW - Serum immunoglobulins PY - 2006 SP - 11 EP - 16 TI - Relationship of serum immunoglobulin and IgG subclass levels to race, ethnicity and behavioral characteristics in HIV infection T2 - Medical Science Monitor VL - 12 ER - TY - JOUR AB - Background: The primary endpoint was to investigate the prognostic factors of acute mesenteric ischemia (AMI) in ICU patients. Methods: Retrospective observational, non-interventional, monocentric study of a cohort of 214 ICU patients with a confirmed diagnosis of arterial AMI. Results: We collected demographics, mortality, hospital stay, prior medical history, comorbidities, reasons for ICU admission, laboratory investigations, diagnostic procedures, therapy, severity scores. The 30-day mortality rate was 71% for the 214 patients with arterial AMI. The incidence of nonocclusive mesenteric ischemia was particularly high. AMI was a secondary diagnosis in 58% of patients. Half of the population was represented by surgical patients who mostly required an urgent procedure. The mortality rate was not different in the subgroup with aortic surgery. Three factors were associated with an increase or decrease in mortality: the maximal dose of vasopressors (VP) administered to the patient (OR = 1.20; 95%CI = 1.08-1.33; p < 0.001), arterial change in lactate values within the first 24 h of admission (OR = 1.24; 95%CI = 1.05-1.48; p = 0.012) and anticoagulation (OR = 0.19; 95%CI = 0.043-0.84; p = 0.029). Conclusions: Fatalities after AMI were related to a high incidence of multi-organ failure. The monitoring of arterial lactate appeared helpful to identify the patients with a poor prognosis. AU - Caluwaerts, Martin AU - Castanares-Zapatero, Diego AU - Laterre, Pierre François AU - Hantson, Philippe DO - 10.1186/s12876-019-0999-8 IS - 1 KW - Arterial acute mesenteric ischemia KW - ICU patients KW - Mortality KW - Prognostic factors PB - BMC Gastroenterology PY - 2019 SP - 1 EP - 10 TI - Prognostic factors of acute mesenteric ischemia in ICU patients T2 - BMC Gastroenterology VL - 19 ER - TY - JOUR AB - Symptomatic visceral atherosclerosis is a major surgical challenge because of its life-threatening course and the complexity of its definitive operative treatment. Evolution in the operative approach to the visceral aorta and progress in the intraoperative management of patients undergoing complex vascular reconstructions prompted a review of the authors' cumulative experience in the surgical management of chronic visceral ischemia. Among all patients undergoing visceral revascularization at the University of California, San Francisco during the past three decades, 74 patients were identified whose primary reconstruction used transaortic endarterectomy (TA TEA) (n = 48) or antegrade bypass (AB) (n = 26), the authors' preferred revascularization techniques. The two treatment groups were comparable in gender distribution, age, presenting symptoms, and physical findings, although the amount of preoperative weight loss was greater in the AB group (35.8 ± 19.5 versus 22.4 ± 12.0, p = 0.003). The groups were also comparable in the prevalence of atherosclerosis risk factors, symptomatic vascular disease at other sites, and previous vascular operations. However associated renal artery atherosclerosis was slightly greater in the TA TEA group (58.3% versus 23.1%, p = 0.07) when compared to the AB group. Antegrade bypass was usually performed transabdominally (88.5%), while TA TEA was approached thoracoretroperitoneally (75.0%). Celiac revascularization was almost universal in both treatment groups, but the TA TEA group underwent significantly more frequent superior mesenteric artery (SMA) revascularization (93.8% versus 46.2%, p = 0.0001) and slightly more frequent inferior mesenteric repair (18.8% versus 3.8%, p = 0.07) than the AB group. In addition the frequency of combined renal and visceral repair (25.0% versus 0.0%, p = 0.01) as well as combined aortic, renal, and visceral repair (22.9% versus 3.8%, p = 0.03) was significantly greater in the TA TEA group. The obligatory interval of renal and visceral ischemia did not differ between the two approaches. The perioperative mortality rate was 12.2% and was the same for TA TEA (14.6%) and AB (7.7%). Overall the incidence of complications was the same with either operative approach, although patients in the TA TEA group tended to have multiple complications (17.1% versus 0.0, p = 0.03) and all significant pulmonary complications occurred in this group. Two patients were lost to follow-up. The cumulative percentage of patients who remained asymptomatic following AB or TA TEA was (respectively) 95.8% and 97.3% at 1 year and 86.5% and 86.1% at 5 years. Both of these operative approaches provide durable symptom relief with acceptable operative morbidity and mortality rates. These results are attributed to intraoperative transesophageal echocardiography, to intraoperative assessment of the visceral reconstruction with Duplex ultrasonography, and to the increasing use of the transabdominal approach, with medial visceral rotation, to provide aortic exposure for both AB and TA TEA techniques. AU - Cunningham, C. G. AU - Reilly, L. M. AU - Rapp, J. H. AU - Schneider, P. A. AU - Stoney, R. J. DO - 10.1097/00000658-199109000-00010 IS - 3 PY - 1991 SP - 276 EP - 288 TI - Chronic visceral ischemia: Three decades of progress T2 - Annals of Surgery VL - 214 ER - TY - JOUR AB - Mesenteric venous thrombosis is an uncommon but potentially lethal cause of bowel ischemia. Several imaging methods are available for diagnosis, each of which has advantages and disadvantages. Doppler ultrasonography allows direct evaluation of the mesenteric and portal veins, provides semiquantitative flow information, and allows Doppler waveform analysis of the visceral vessels; however, it is operator dependent and is often limited by overlying bowel gas. Conventional contrast material-enhanced computed tomography (CT) allows sensitive detection of venous thrombosis within the central large vessels of the portomesenteric circulation and any associated secondary findings; however, it is limited by respiratory misregistration, motion artifact, and substantially decreased longitudinal spatial resolution. Helical CT and CT angiography, especially when performed with multi-detector row scanners, and magnetic resonance (MR) imaging, particularly gadolinium-enhanced MR angiography, enable volumetric acquisitions in a single breath hold, eliminating motion artifact and suppressing respiratory misregistration. Helical CT angiography and three-dimensional gadolinium-enhanced MR angiography should be considered the primary diagnostic modalities for patients with a high clinical suspicion of mesenteric ischemia. Conventional angiography is reserved for equivocal cases at noninvasive imaging and is also used in conjunction with transcatheter therapeutic techniques in management of symptomatic portal and mesenteric venous thrombosis. © RSNA, 2002. AU - Bradbury, Michelle S. AU - Kavanagh, Peter V. AU - Bechtold, Robert E. AU - Chen, Michael Y. AU - Ott, David J. AU - Regan, John D. AU - Weber, Therese M. DO - 10.1148/radiographics.22.3.g02ma10527 IS - 3 KW - Computed tomography (CT), angiography, 957.12916, KW - Magnetic resonance (MR), vascular studies, 957.129 KW - Portal vein, thrombosis, 957.751 KW - Veins, mesenteric, 959.751 KW - Veins, thrombosis, 957.751, 959.751 PY - 2002 SP - 527 EP - 541 TI - Mesenteric venous thrombosis: Diagnosis and noninvasive imaging T2 - Radiographics VL - 22 ER - TY - JOUR AB - El tratamiento quirúrgico de la isquemia digestiva se basa en un conocimiento adecuado de la fisiopatología de la isquemia mesentérica, del tratamiento quirúrgico urgente, de la necrosis digestiva y de las técnicas clásicas de revascularización (trombectomías, endarterectomías y derivaciones), así como en la angioplastia con colocación de endoprótesis en las arterias viscerales, cuyas indicaciones son cada vez más frecuentes. Los progresos de las pruebas de imagen han permitido definir mejor las lesiones accesibles a un tratamiento etiológico, incluso en las situaciones urgentes. De forma paralela, los avances en cirugía digestiva y el papel del gastroenterólogo han participado en la mejora de la estrategia terapéutica. AU - Brunetti, F. AU - Kobeiter, H. AU - Le Baleur, Y. AU - Marzelle, J. DO - 10.1016/s1282-9129(17)83672-2 IS - 2 KW - angioplastia KW - celíaco KW - colon KW - derivación KW - embolia KW - endarterectomía KW - endoscopia KW - infarto mesentérico KW - intestino delgado KW - isquemia digestiva KW - laparotomía KW - mesentérica KW - reanimación KW - tomografía computarizada KW - trombosis PY - 2017 SP - 1 EP - 17 TI - Tratamiento quirúrgico de la isquemia digestiva T2 - EMC - Técnicas Quirúrgicas - Aparato Digestivo VL - 33 ER - TY - JOUR AB - Background Nonocclusive mesenteric ischemia can cause intestinal infarction but the diagnosis is challenging. This prospective study evaluated three plasma biomarkers of intestinal infarction after cardiac surgery. Materials and methods Patients were recruited after cardiac surgery if they required laparotomy (with or without intestinal resection) for suspected nonocclusive mesenteric ischemia. Plasma levels of D-lactate, intestinal fatty acid–binding protein (i-FABP), and smooth muscle actin (SMA) before laparotomy were measured. Results Twenty patients were recruited (68 ± 9 y, EuroSCORE: 8.7 ± 2.8, mortality 70%). A positive laparotomy (n = 13) was associated with no change in D-lactate (P = 0.95), decreased i-FABP (P = 0.007), and increased SMA (P = 0.01). All patients with high SMA had a positive laparotomy. A subgroup analysis was undertaken in the eight patients who required multiple laparotomies. D-lactate increased between the two laparotomies in nonsurvivors (n = 4). Plasma i-FABP (P = 0.008) and SMA (P = 0.036) significantly decreased after the bowel resection, regardless of survival outcome. Conclusions None of the biomarkers were accurate enough to reliably diagnose intestinal infarction. However, all patients with high values of SMA developed intestinal infarction, thus warranting further investigation. An increasing D-lactate after intestinal resection suggests impending death. AU - Hong, Jiwon AU - Gilder, Eileen AU - Blenkiron, Cherie AU - Jiang, Yannan AU - Evennett, Nicholas J. AU - Petrov, Maxim S. AU - Phillips, Anthony R.J. AU - Windsor, John A. AU - Gillham, Michael DO - 10.1016/j.jss.2016.12.001 KW - Biomarker KW - D-lactate KW - Intestinal fatty acid–binding protein KW - Nonocclusive mesenteric ischemia KW - Smooth muscle actin PB - Elsevier Inc PY - 2017 SP - 21 EP - 29 TI - Nonocclusive mesenteric infarction after cardiac surgery: potential biomarkers T2 - Journal of Surgical Research UR - http://dx.doi.org/10.1016/j.jss.2016.12.001 VL - 211 ER - TY - JOUR AB - Acute mesenteric ischemia is a rare life-threatening condition that accounts for approximately one in 1000 hospital admissions. The mortality rate is 50%–69% owing to the absence of specific symptoms and laboratory data, which makes early detection of this condition difficult. If the use of contrast material is possible, biphasic contrast material–enhanced multidetector computed tomography (CT) is the first-line imaging test for early diagnosis of the disease and for differentiation from other causes of acute abdomen. Multidetector CT can depict mesenteric ischemia, its underlying causes, and its severity. Mesenteric ischemia is classified as either acute or chronic. The causes of AMI include arterial embolism, arterial thrombosis, venous thrombosis, and nonocclusive mesenteric ischemia, among which arterial causes are far more common than venous causes. Recently, endovascular procedures such as thrombolysis, thrombectomy, thrombus fragmentation, and stent placement have been successfully and safely performed when the ischemia is reversible. AU - Kanasaki, Shuzo AU - Furukawa, Akira AU - Fumoto, Kanako AU - Hamanaka, Yasuyo AU - Ota, Shinichi AU - Hirose, Tomohiro AU - Inoue, Akitoshi AU - Shirakawa, Takako AU - Nguyen, Linh Dai Hung AU - Tulyeubai, Syerikjan DO - 10.1148/rg.2018170163 IS - 3 PY - 2018 SN - 2018170163 SP - 945 EP - 961 TI - Acute mesenteric Ischemia: Multidetector CT findings and endovascular management T2 - Radiographics VL - 38 ER - TY - JOUR AB - Intestinal ischemia and infarction are a heterogeneous group of diseases that have as their unifying theme hypoxia of the small bowel or colon. The incidence of bowel ischemia and infarction is on the rise for several reasons: the aging of the population, the ability of intensive care units to salvage critically ill patients, and heightened clinical awareness of these disorders. Improvements in diagnostic imaging techniques have greatly contributed to the earlier diagnosis of intestinal ischemia, which can have a positive influence on patient outcomes. In this article, role of radiology in the detection, differential diagnosis, and management of patients who have intestinal ischemia and infarction is discussed. © 2008 Elsevier Inc. All rights reserved. AU - Gore, Richard M. AU - Yaghmai, Vahid AU - Thakrar, Kiran H. AU - Berlin, Jonathan W. AU - Mehta, Uday K. AU - Newmark, Geraldine M. AU - Miller, Frank H. DO - 10.1016/j.rcl.2008.05.004 IS - 5 KW - CT colon KW - CT small bowel KW - Ischemic colitis KW - Mesenteric infarction KW - Mesenteric ischemia PY - 2008 SP - 845 EP - 875 TI - Imaging in Intestinal Ischemic Disorders T2 - Radiologic Clinics of North America VL - 46 ER - TY - JOUR AB - Abstract: Acute mesenteric ischaemia (AMI) is an uncommon cause of acute hospital admission with high mortality rates (50–90%) that requires early diagnosis and treatment. With the increase in average life expectancy, AMI represents one of the most threatening abdominal conditions in elderly patients. Untreated, AMI will cause mesenteric infarction, intestinal necrosis, an overwhelming inflammatory response and death. Early intervention can reverse this process leading to a full recovery, but the diagnosis of AMI is difficult. The failure to recognise AMI before intestinal necrosis has developed is responsible for the high mortality of the disease. Unfortunately, common CT findings in bowel ischaemia are not specific. Therefore, it is often a combination of nonspecific clinical, laboratory and radiological findings that helps most in the correct interpretation of CT findings. The purpose of this article is to provide an overview of the anatomy, physiology of mesenteric perfusion and discussions of causes, pathogenesis and CT findings in various types of acute bowel ischaemia. Familiarity with various imaging features of mesenteric injury is essential to make a timely diagnosis that will lead to improved patient outcomes. Teaching Points: • AMI is a potentially life-threatening disorder whose prognosis depends on early recognition, accurate diagnosis and timely intervention. • Arterial inflow occlusion due to thrombosis or embolisation is the most common cause of AMI. • Four aetiological types of AMI have been associated with different characteristics and risk factors (EAMI, TAMI, VAMI and NOMI). • Physical examination and laboratory findings are not sensitive or specific for diagnosing AMI; therefore, MDCT is still the first-line imaging method in suspected AMI. • Although a number of scoring systems for prognosis have been proposed, these have not been validated in large-scale studies. AU - Florim, S. AU - Almeida, A. AU - Rocha, D. AU - Portugal, P. DO - 10.1007/s13244-018-0641-2 IS - 5 KW - Computed tomography KW - Ischaemia/diagnosis KW - Mesenteric ischaemia KW - Mesenteric vascular occlusion/diagnosis KW - Pneumatosis intestinal PB - Insights into Imaging PY - 2018 SN - 1324401806412 SP - 673 EP - 682 TI - Acute mesenteric ischaemia: a pictorial review T2 - Insights into Imaging VL - 9 ER - TY - JOUR AB - These guidelines are dedicated to Paola De Rango, University of Perugia, Italy. She participated very actively in the process of developing these guidelines, in particular the important chapters on chronic arterial and venous mesenteric ischaemia. Six days after the second meeting of the task force she died unexpectedly, to our great despair and loss. We honour her dedication and scientific integrity by completing these guidelines. Among many other commitments she was a very productive reviewer and an associate editor of this journal. You can read more about Paola's important contributions to science and to the vascular community in the April 2016 issue of the European Journal of Vascular and Endovascular Surgery.1[Figure presented] Dr Paola De Rango, July 28, 1966 – February 21, 2016 AU - Björck, M. AU - Koelemay, M. AU - Acosta, S. AU - Bastos Goncalves, F. AU - Kölbel, T. AU - Kolkman, J. J. AU - Lees, T. AU - Lefevre, J. H. AU - Menyhei, G. AU - Oderich, G. AU - Kolh, P. AU - de Borst, G. J. AU - Chakfe, N. AU - Debus, S. AU - Hinchliffe, R. AU - Kakkos, S. AU - Koncar, I. AU - Sanddal Lindholt, J. AU - Vega de Ceniga, M. AU - Vermassen, F. AU - Verzini, F. AU - Geelkerken, B. AU - Gloviczki, P. AU - Huber, T. AU - Naylor, R. AU - Kolh, P. AU - de Borst, G. J. AU - Chakfe, N. AU - Debus, S. AU - Hinchliffe, R. AU - Sanddal Lindholt, J. AU - Vega de Ceniga, M. AU - Vermassen, F. DO - 10.1016/j.ejvs.2017.01.010 IS - 4 KW - Acute mesenteric ischaemia KW - Arterial embolism KW - Arterial thrombosis KW - Chronic mesenteric ischaemia KW - Guidelines KW - Isolated dissections of the mesenteric arteries KW - Mesenteric arterial aneurysms KW - Mesenteric venous thrombosis KW - Non-occlusive mesenteric ischaemia KW - Venous mesenteric ischaemia PB - Elsevier Ltd PY - 2017 SP - 460 EP - 510 TI - Editor's Choice – Management of the Diseases of Mesenteric Arteries and Veins: Clinical Practice Guidelines of the European Society of Vascular Surgery (ESVS) T2 - European Journal of Vascular and Endovascular Surgery UR - http://dx.doi.org/10.1016/j.ejvs.2017.01.010 VL - 53 ER - TY - JOUR AB - Introduction: Acute intestinal ischemia is in most cases a lethal condition with a low survival rate. Risk factors of perioperative mortality are poorly defined. The aim of this study was to define risk factors that predict an adverse outcome of acute mesenteric ischemia (AMI). Methods: A total of 132 consecutive patients (73 men, 59 women), mean ± SD age 71.96 ± 13.64 years, who underwent surgery because of AMI in a university tertiary care center were evaluated over a period of 10 years. Clinical features, laboratory findings, etiologic factors, and surgical procedures were recorded and assessed as possible risk factors for perioperative mortality. Results: Of 132 patients, 86 (65.2%) died during the perioperative period as a direct result of AMI. Significant univariate predictors of perioperative mortality were age (P = 0.01), cardiopathy (P = 0.002), digoxin intake (P = 0.015), shock (P = 0.01), urea plasma level (P < 0.001), creatinine (P < 0.001), potassium (P = 0.042), low pH (P = 0.015) and bicarbonate (P = 0.035); hemoglobin ≥ 2.48 mmol/L (P = 0.035); time delay to surgery (P = 0.023); colonic involvement (P < 0.001); small and large bowel involvement (P < 0.001); arterial versus venous ischemia (P = 0.007); and intestinal resection (P < 0.001). In the multivariate analysis, the variables previous cardiac illness (P = 0.045), urea plasma levels (P < 0.001), and small and large bowel involvement were identified as independent risk factors of perioperative mortality. Intestinal resection (P < 0.001) was a favorable predictor. Conclusions: Age, time delay to surgery, shock, and acidosis significantly increase the risk of mortality due to AMI, whereas intestinal resection has a protective effect. However, only previous cardiac illness, acute renal failure, and large bowel ischemia have a negative effect as independent risk factors of mortality of AMI. © 2006 by the Société Internationale de Chirurgie. AU - Acosta-Merida, Maria Asuncion AU - Marchena-Gomez, Joaquin AU - Hemmersbach-Miller, Marion AU - Roque-Castellano, Cristina AU - Hernandez-Romero, Juan Maria DO - 10.1007/s00268-005-0560-5 IS - 8 PY - 2006 SP - 1579 EP - 1585 TI - Identification of risk factors for perioperative mortality in acute mesenteric ischemia T2 - World Journal of Surgery VL - 30 ER - TY - JOUR AB - Background: Despite constant improvements in diagnostic as well as interventional and surgical techniques, acute mesenteric ischemia (AMI) remains a life-threatening emergency with high mortality rates. The time to diagnosis of AMI is the most important predictor of patients' outcome; therefore, prompt diagnosis and intervention are essential to reduce mortality in patients with AMI. The present review was performed to analyze potential risk factors and to help find ways to improve the outcome of patients with AMI. Summary: Whereas AMI only applies to approximately 1%of all patients with an "acute abdomen,"its incidence is rising up to 10%in patients >70 years of age. The initial clinical stage of AMI is characterized by a sudden onset of strong abdominal pain followed by a painless interval. Depending on the extent of disease, the symptoms of nonocclusive mesenteric ischemia (NOMI) and patients with a venous thrombosis can be very different from those of acute occlusive ischemia. Biphasic contrast-enhanced CT represents the gold standard for the diagnosis of arterial and venous occlusion. In case of a central occlusion of the superior mesenteric artery or signs of peritonitis, immediate surgery should be performed. If major bowel resection becomes necessary, critical residual intestinal length limits must be kept in mind. Endovascular techniques for arterial occlusion have taken on a much greater importance today. For stable patients with NOMI, interventional catheter angiography is recommended because it enables diagnosis and treatment with selective application of vasodilators. Depending on its degree, interventional treatment with a transhepatic catheter lysis should be considered for acute and chronic portal vein thrombosis. Key Message: The prompt and targeted use of the appropriate diagnostics and interventions appears to be the only way to reduce the persistently high mortality rates for AMI. AU - Oldenburg, W. Andrew AU - Lau, Louis AU - Rodenberg, Thomas AU - Edmonds, Hope AU - Burger, Charles DO - 10.1159/000508739 IS - 4 KW - Acute mesenteric ischemia KW - Critical care KW - Diagnosis KW - Diagnostic imaging KW - Endovascular procedures KW - Mortality KW - Portal vein thrombosis KW - Surgery PY - 2020 SP - 256 EP - 263 TI - Acute Mesenteric Ischemia T2 - Visceral Medicine VL - 36 ER - TY - JOUR AB - Acute mesenteric ischemia (AMI) is typically defined as a group of diseases characterized by an interruption of the blood supply to varying portions of the small intestine, leading to ischemia and secondary inflammatory changes. If untreated, this process will eventuate in life threatening intestinal necrosis. The incidence is low, estimated at 0.09-0.2% of all acute surgical admissions. Therefore, although the entity is an uncommon cause of abdominal pain, diligence is always required because if untreated, mortality has consistently been reported in the range of 50%. Early diagnosis and timely surgical intervention are the cornerstones of modern treatment and are essential to reduce the high mortality associated with this entity. The advent of endovascular approaches in parallel with modern imaging techniques may provide new options. Thus, we believe that a current position paper from World Society of Emergency Surgery (WSES) is warranted, in order to put forth the most recent and practical recommendations for diagnosis and treatment of AMI. This review will address the concepts of AMI with the aim of focusing on specific areas where early diagnosis and management hold the strongest potential for improving outcomes in this disease process. Some of the key points include the prompt use of CT angiography to establish the diagnosis, evaluation of the potential for revascularization to re-establish blood flow to ischemic bowel, resection of necrotic intestine, and use of damage control techniques when appropriate to allow for re-assessment of bowel viability prior to definitive anastomosis and abdominal closure. AU - Bala, Miklosh AU - Kashuk, Jeffry AU - Moore, Ernest E. AU - Kluger, Yoram AU - Biffl, Walter AU - Gomes, Carlos Augusto AU - Ben-Ishay, Offir AU - Rubinstein, Chen AU - Balogh, Zsolt J. AU - Civil, Ian AU - Coccolini, Federico AU - Leppaniemi, Ari AU - Peitzman, Andrew AU - Ansaloni, Luca AU - Sugrue, Michael AU - Sartelli, Massimo AU - Di Saverio, Salomone AU - Fraga, Gustavo P. AU - Catena, Fausto DO - 10.1186/s13017-017-0150-5 IS - 1 KW - Guidelines KW - Mesenteric angiography KW - Mesenteric arterial occlusion KW - Mesenteric artery stenting KW - Mesenteric ischemia KW - Recommendations KW - Small bowel ischemia PB - World Journal of Emergency Surgery PY - 2017 SP - 1 EP - 11 TI - Acute mesenteric ischemia: Guidelines of the World Society of Emergency Surgery T2 - World Journal of Emergency Surgery VL - 12 ER - TY - JOUR AB - Background: Early identification of patients with acute mesenteric ischemia (AMI) involving the large bowel may play a decisive role in improving the prognosis of AMI. This study aims to compare the outcomes between patients with isolated AMI and AMI patients with colon involvement (CI) and to identify the predictors of worse outcomes. The different surgical modalities for AMI patients with CI were also evaluated. Methods: This retrospective cohort study included 199 AMI patients admitted from January 2005 to January 2014. Based on colonoscopy and pathology reports, 39 patients were diagnosed as AMI with CI, and 160 were AMI patients without CI. The clinical outcomes and different surgical modalities were compared. Risk factors of 30-d mortality and short bowel syndrome (SBS) were identified. Results: The 30-d mortality (10% versus 49%, P < 0.01) and SBS incidence (19% versus 49%, P < 0.01) were higher in AMI patients with CI than AMI patients without CI. AMI patients with CI have higher rate of bowel resection (68% versus 95%, P < 0.001) and second-look laparotomy (25% versus 54%, P < 0.001) than patients with AMI alone. For AMI patients with CI, emergent laparotomy was associated with shorter hospital stay (P = 0.04) and less incidence of SBS (74% versus 25%, P < 0.001) than initial endovascular therapy. Patients with ostomy had less repeated bowel resection (11% versus 63%, P = 0.001) and rate of SBS (21% versus 79%, P < 0.001) than patients with primary bowel anastomosis. Serum procalcitonin level and colon ischemia were risk factors of 30-d mortality and SBS for AMI. Conclusions: AMI patients with CI represent a special cohort of AMI patients with higher risk of poor outcome. Compared to initial endovascular therapy, emergent laparotomy was associated with shorter length of hospital stay and reduced incidence of SBS. AU - Yang, Shuofei AU - Zhao, Yiping AU - Chen, Jiaquan AU - Ni, Qihong AU - Guo, Xiangjiang AU - Huang, Xiaozhong AU - Xue, Guanhua AU - Zhang, Lan DO - 10.1016/j.jss.2018.08.010 KW - Acute bowel infarction KW - Anatomic patterns KW - Colon ischemia KW - Surgical modality PB - Elsevier Inc PY - 2019 SP - 231 EP - 239 TI - Clinical features and outcomes of patients with acute mesenteric ischemia and concomitant colon ischemia: a retrospective cohort study T2 - Journal of Surgical Research UR - https://doi.org/10.1016/j.jss.2018.08.010 VL - 233 ER - TY - JOUR AB - The short bowel syndrome (SBS) is a complex entity due to anatomical or functional loss of part of the small bowel originating a clinical picture with severe metabolic and nutritional impairments due to reduction of the effective absorptive surface area of the gut. SBS is one of the causes of a larger entity known as "intestinal failure". Currently, mesenteric vascular accidents are the main cause in adults, followed by inflammatory bowel disease, and radiation enteritis, whereas in children, the main causes are congenital and perinatal diseases. The clinical picture associated with SBS varies according to the length and location of affected small bowel, the presence of underlying disease, the presence or absence of the large bowel and ileocecal valve, and the nature of the underlying disease. Intestinal adaptation is the process by which, throughout 1-2 years, intestinal absorption is reestablished to the situation prior to intestinal resection, and is a key factor determining whether a patient with SBS will progress to intestinal failure and depend on DPN. Intestinal adaptation may take place if the patient does oral intake higher than the usual one (hyperphagia); besides, the bowel may also adapt to secure a more effective absorption per surface area unit, either by increasing the absorptive surface area (structural adaptation) and/or slowing intestinal transit (functional adaptation). These changes are not still clearly established in humans, but there are so in animal models. The presence of nutrients within the intestinal lumen and certain gastrointestinal hormones, particularly GLP-2, have an influence on a successful adaptation process. Patients with SBS are prone to the occurrence of bacterial overgrowth that makes adaptation difficult and worsens the symptoms, besides being a factor for dependence on parenteral nutrition. AU - Ballesteros Pomar, María D. AU - Vidal Casariego, A. IS - SUPPL. 2 KW - Bacterial overgrowth KW - Intestinal adaptation KW - Intestinal failure KW - Short bowel PY - 2007 SP - 74 EP - 85 TI - Síndrome de intestino corto: Definición, causas, adaptación intestinal y sobrecrecimiento bacteriano T2 - Nutricion Hospitalaria VL - 22 ER - TY - JOUR AU - Boley, Scott J AU - Brandt, Lawrence J AU - Sammartano, Robert J IS - 2 PY - 1997 TI - History of mesenteric ischemia the evolution of a diagnosis and managenement T2 - surgical clinics of north america VL - 77 ER - TY - JOUR AB - Thromboembolic episode is a well known extraintestinal manifestation of inflammatory bowel disease, but it is a clinical rare complication. Histological and hematological studies suggest that a hypercoagulable state is involved in the pathogenesis of inflammatory bowel disease. However, the exact mechanism of hypercoagulability is still unknown. During the acute recurrences there is an increase of factor offactor VIII, fibrinogen, platelet, factor V and decrease of antithrombin 111. Hematologic disorders seem markedly correlated with the activity of the disease. We report on two patients with Inflammatory bowel disease and hypercoagulable state. We review the literature and discuss about the pathogenic mechanisms of such complication. AU - Baños Madrid, Ramón AU - Salama Benarroch, H. AU - Martínez Crespo, J. AU - Morán Sánchez, S. AU - Vargas Acosta, A. AU - Mercader Martínez, J. DO - 10.4321/s0212-71992003000200008 IS - 2 KW - Extraintestinal manifestations KW - Hypercoagulability KW - Inflammatory bowel disease PY - 2003 SP - 81 EP - 84 TI - Complicaciones vasculares asociadas a la enfermedad inflamatoria intestinal T2 - Anales de Medicina Interna VL - 20 ER - TY - JOUR AB - BACKGROUND Mesenteric vein thrombosis occurs rarely and is responsible for approximately 5-15% of all cases of acute mesenteric ischemia. The aim of this report was to discuss the management of mesenteric vein thrombosis based on our experience with 34 patients. METHODS In the present study, 34 patients who were admitted to our emergency surgery department between January 2007 and January 2010 with a diagnosis of acute mesenteric vein thrombosis were assessed retrospectively. Patients with peritoneal signs first underwent diagnostic laparoscopy to rule out perforation or bowel gangrene. We performed a second-look laparoscopy within 72 hours of the first operation. All patients were administered 100 mg/kg of the anticoagulant enoxaparin twice daily. In the 6th and 12th months of follow up, CT angiography was performed to evaluate recanalization of the veins. RESULTS CT angiography revealed superior mesenteric vein thrombosis in 25 (73%) patients, portal vein thrombosis in 24 (70%) patients, and splenic vein thrombosis in 12 (35%) patients. Eleven patients with peritoneal signs underwent diagnostic laparoscopy; eight of the patients underwent small bowel resection, anastomosis, and trocar insertion. During second-look laparoscopy, small bowel ischemia was found in two patients and re-resection was performed. CONCLUSION Early diagnosis with CT angiography, surgical and nonsurgical blood flow restoration, proper anticoagulation, and supportive intensive care are the cornerstones of successful treatment of mesenteric vein thrombosis. AU - Yanar, Fatih AU - Aǧcaoǧlu, Orhan AU - Gök, Ali Fuat Kaan AU - Sarici, Inanç Şamil AU - Özçinar, Beyza AU - Aksakal, Nihat AU - Aksoy, Murat AU - Özkurt, Enver AU - Kurtoǧlu, Mehmet DO - 10.5505/tjtes.2013.47542 IS - 3 KW - Algorithm KW - Antithrombotic therapy KW - Mesenter vein KW - Thrombosis PY - 2013 SP - 223 EP - 228 TI - The management of mesenteric vein thrombosis: A single institution's experience T2 - Ulusal Travma ve Acil Cerrahi Dergisi VL - 19 ER - TY - JOUR AB - A 79-yr-old man with previously documented atherosclerotic vascular disease presented with acute abdominal pain, signs of peritoneal irritation, and guaiac-positive stool. A mesenteric arteriogram showed high-grade stenosis of the superior mesenteric artery with a pressure gradient of 70 mmHg and complete occlusion of the inferior mesenteric artery. Percutaneous transluminal angioplasty of the superior mesenteric artery was performed with immediate reduction of the pressure gradient, increase in vessel caliber, and relief of abdominal pain. The patient went on to complete recovery and remains pain-free 6 mo after discharge from the hospital. To our knowledge, this is the first report of percutaneous transluminal angioplasty used to treat acute mesenteric ischemia. © 1986. AU - VanDeinse, William H. AU - Zawacki, John K. AU - Phillips, David DO - 10.1016/0016-5085(86)90586-X IS - 2 PB - Elsevier Inc. PY - 1986 SP - 475 EP - 478 TI - Treatment of acute mesenteric ischemia by percutaneous transluminal angioplasty T2 - Gastroenterology UR - http://dx.doi.org/10.1016/0016-5085(86)90586-X VL - 91 ER - TY - JOUR AB - Background: To analyze demography, clinical signs, and survival of intensive care patients diagnosed with nonocclusive mesenteric ischemia (NOMI) and to evaluate the effect of a local intra-arterial prostaglandin therapy. Methods: Retrospective observational study screening 455 intensive care patients with acute arterial mesenteric perfusion disorder in a tertiary care hospital within the past 8 years. Lastly, 32 patients with NOMI were enrolled, of which 11 received local intra-arterial prostaglandin therapy. The diagnosis of NOMI was based on the clinical presentation and established biphasic computed tomography criteria. Clinical and biochemical data were obtained 24 hours before, at the time, and 24 hours after diagnosis. Results: Patients were 60.5 (49.3-73) years old and had multiple comorbidities. Most of them were diagnosed with septic shock requiring high doses of norepinephrine (NE: 0.382 [0.249-0.627] μg/kg/min). The Sequential Organ Failure Assessment (SOFA) score was 18 (16-20). A decrease in oxygenation (Pao2/Fio2), pH, and bicarbonate and an increase in international normalized ratio, lactate, bilirubin, leucocyte count, and NE dose were early indicators of NOMI. Median SOFA score significantly increased in the last 24 hours before diagnosis of NOMI (16 vs 18, P <.0001). Overall, 28-day mortality was 75% (81% nonintervention vs 64% intervention cohort; P =.579). Median SOFA scores 24 hours after intervention increased by +5% in the nonintervention group and decreased by 5.5% in the intervention group (P =.0059). Conclusions: Our data suggest that NOMI is a detrimental disease associated with progressive organ failure and a high mortality. Local intra-arterial prostaglandin application might hold promise as a rescue treatment strategy. These data encourage future randomized controlled trials are desirable. AU - Stahl, Klaus AU - Busch, Markus AU - Maschke, Sabine K. AU - Schneider, Andrea AU - Manns, Michael P. AU - Fuge, Jan AU - Wiesner, Olaf AU - Meyer, Bernhard C. AU - Hoeper, Marius M. AU - Hinrichs, Jan B. AU - David, Sascha DO - 10.1177/0885066619837911 IS - 11 KW - intestinal failure KW - nonocclusive mesenteric ischemia KW - sepsis KW - shock PY - 2020 SP - 1162 EP - 1172 TI - A Retrospective Analysis of Nonocclusive Mesenteric Ischemia in Medical and Surgical ICU Patients: Clinical Data on Demography, Clinical Signs, and Survival T2 - Journal of Intensive Care Medicine VL - 35 ER - TY - JOUR AB - Chronic mesenteric ischemia (CMI) is the most common vascular disorder involving the intestines, however it is unusual in clinical practice. The redundancy of the visceral circulation with multiple interconnections between the superior mesenteric artery (SMA) and the inferior mesenteric artery (IMA) is the most likely explanation for the infrequent occurrence of CMI in clinical practice. Atherosclerosis is by the far the most common etiology of CMI. The increased utilization of diagnostic abdominal cross-sectional imaging has increased the recognition of atherosclerotic mesenteric stenoses. CMI is a clinical diagnosis, based upon symptoms and consistent anatomic findings. The classic setting for CMI is a female patient presenting with post-prandial abdominal discomfort that results in significant weight loss. Endovascular therapy with stenting has become the most common method chosen for revascularization having replaced open surgery with its associated morbidity and mortality. © 2011 Elsevier Inc. AU - White, Christopher J. DO - 10.1016/j.pcad.2011.04.005 IS - 1 KW - Chronic mesenteric ischemia KW - Mesenteric artery disease KW - Mesenteric stenosis KW - Mesenteric stent KW - Revascularization KW - Visceral ischemia PB - Elsevier Inc. PY - 2011 SP - 36 EP - 40 TI - Chronic Mesenteric Ischemia: Diagnosis and Management T2 - Progress in Cardiovascular Diseases UR - http://dx.doi.org/10.1016/j.pcad.2011.04.005 VL - 54 ER - TY - JOUR AU - Madison H. Fletcher, and William M. Wuest Sean E. Rossiter DO - 10.1016/j.jss.2019.01.034.Magnetoenterography IS - 3 KW - endothelium KW - estrogen KW - estrogen receptors KW - vascular smooth muscle PY - 2019 SP - 31 EP - 37 TI - Magnetoenterography for the Detection of Partial Mesenteric Ischemia T2 - J Surg Res VL - 239 ER - TY - JOUR AB - Objectives: Despite modern advances in diagnosis and treatment, acute arterial mesenteric ischaemia (AMI) remains a high mortality disease. One of the key modifiable factors in AMI is the first door to operation time, but the factors attributing to this parameter are largely unknown. The aim of this study was to evaluate the factors affecting delay, with special focus on the pathways to treatment. Methods: This was a single academic centre retrospective study. Patients undergoing intervention for AMI caused by thrombosis or embolism of the superior mesenteric artery between 2006 and 2015 were identified from electronic patient records. Patients not eligible for intervention or with chronic, subacute onset, colonic only, venous, or non-occlusive mesenteric ischaemia were excluded. Patients were divided into two groups according to the first speciality examining the patient (surgical emergency room [SER], surgeon examining the patient first or non-surgical emergency room [non-SER], internist examining the patient first). The primary endpoint was first door to operation time and secondary endpoints were length of stay and 90 day mortality. Results: Eighty-one patients with AMI were included. Fifty patients (62%) died during the first 30 days and 53 (65%) within 90 days. Presenting first in non-SER (vs. SER) was independently associated with a first door to operation time of over 12 h (OR 3.7 [95% CI 1.3–10.2], median time 15.2 h [IQR 10.9–21.2] vs. 10.1 h [IQR 6.9–18.5], respectively, p =.025). The length of stay was shorter (median 6.5 days [4.0–10.3] vs. 10.8 days [7.0–22.3], p =.045) and 90 day mortality was lower in the SER group (50.0% vs. 74.5%, p =.025). Conclusions: The first specialty that the patient encounters seems to be crucial for both delayed management and early survival of AMI. Developing fast/direct pathways to a unit with both gastrointestinal and vascular surgeons offers the possibility of improving the outcome of AMI. AU - Lemma, Aurora N. AU - Tolonen, Matti AU - Vikatmaa, Pirkka AU - Mentula, Panu AU - Vikatmaa, Leena AU - Kantonen, Ilkka AU - Leppäniemi, Ari AU - Sallinen, Ville DO - 10.1016/j.ejvs.2019.01.002 IS - 6 KW - Delay KW - Embolus KW - Emergency KW - Revascularisation KW - Thrombosis PB - Elsevier Ltd PY - 2019 SP - 842 EP - 849 TI - Choice of First Emergency Room Affects the Fate of Patients With Acute Mesenteric Ischaemia: The Importance of Referral Patterns and Triage T2 - European Journal of Vascular and Endovascular Surgery UR - https://doi.org/10.1016/j.ejvs.2019.01.002 VL - 57 ER - TY - JOUR AB - This review focuses on the radiology of mesenteric ischaemia. Covering the acute and chronic presentations, both of which result from impaired vascularisation of the gastrointestinal tract, we evaluate the role of radiographs, ultrasound, CT, MRI, and catheter angiography in the diagnosis of these conditions. Looking to the future, we also assess some of the emerging imaging techniques. Across medicine and surgery there has been a significant shift towards minimally invasive interventions. Although percutaneous revascularisation of chronic mesenteric ischaemia has been performed for some time, there has been a developing trend for the use of such techniques in acute mesenteric ischaemia. We evaluate the available evidence for the use of these percutaneous interventions and assess how they compare with or in some instances compliment traditional surgical alternatives. AU - McCarthy, E. AU - Little, M. AU - Briggs, J. AU - Sutcliffe, J. AU - Tapping, C. R. AU - Patel, R. AU - Bratby, M. J. AU - Uberoi, R. DO - 10.1016/j.crad.2015.02.012 IS - 7 PB - The Royal College of Radiologists PY - 2015 SP - 698 EP - 705 TI - Radiology and mesenteric ischaemia T2 - Clinical Radiology UR - http://dx.doi.org/10.1016/j.crad.2015.02.012 VL - 70 ER - TY - JOUR AB - Acute mesenteric ischemia (AMI) is generally thought to be a rare disease, but in fact, it is more common cause of acute abdomen than appendicitis or ruptured abdominal aortic aneurysm in patients over 75 years of age. In occlusive AMI, surgical treatment without revascularization is associated with as high as 80% overall mortality. It has been shown that early diagnosis with contrast-enhanced computed tomography and revascularization can reduce the overall mortality in AMI by up to 50%. However, only a minority of patients with AMI are being treated actively with revascularization in the United States, and the situation is very likely similar in Europe as well. What can we do to improve diagnostic performance, so that more patients get proper treatment? The diagnosis is a collaborative effort of emergency department surgeons, gastrointestinal and vascular surgeons, and radiologists. The etiological categorization of AMI should be practical and guide the therapy. Furthermore, the limitations of the diagnostic examinations need to be understood with special emphasis on computed tomography findings on patients with slowly progressing “acute-on-chronic” mesenteric ischemia. AU - Kärkkäinen, Jussi M. AU - Acosta, Stefan DO - 10.1016/j.bpg.2016.10.018 IS - 1 KW - Acute mesenteric ischemia KW - Acute on chronic mesenteric ischemia KW - Computed tomography KW - Diagnosis KW - Etiology KW - Incidence KW - Mesenteric venous thrombosis KW - Nonocclusive mesenteric ischemia PY - 2017 SP - 15 EP - 25 TI - Acute mesenteric ischemia (part I) – Incidence, etiologies, and how to improve early diagnosis T2 - Best Practice and Research: Clinical Gastroenterology VL - 31 ER - TY - JOUR AB - Background: Acute mesenteric ischemia is a vascular emergency with mortality above 60%, which requires opportune treatment. However, due to its heterogeneous pathophysiology and differences in degree and extent of ischemic damage, the clinical and radiological manifestations are varied and often nonspecific; consequently, a thorough analysis of antecedents, laboratory studies, and clinical and radiological findings is recommended in order to establish a timely diagnosis. AU - Motta-Ramírez GA, Sánchez-García JC, Ontiveros-Rodríguez A, López-Ramírez MA, Rebollo-Hurtado V, García-Ruiz A, Noyola-Villalobos H PY - 2015 SP - 66 EP - 88 TI - Isquemia mesentérica aguda Acute mesenteric ischemia: an emergency which requires a comprehensive diagnostic approach T2 - Scielo UR - http://webcir.org/revistavirtual/articulos/2016/3_agosto/mex/isquemia_mesenterica.pdf ER - TY - JOUR AB - Background: Acute mesenteric ischemia (AMI) is associated with high morbidity and mortality due in part to its diagnostic difficulty and operative challenges. The purpose of this study was to review our experience of surgical management in patients with this condition and to identify variables associated with adverse outcomes following surgical interventions. Methods: Hospital records and clinical data of all patients undergoing surgical interventions for AMI were reviewed during a recent 12-year period. Clinical outcomes as well as factors influencing mortality were analyzed. Results: A total of 72 patients (41 females, overall mean age 65 years, range 34 to 83 years) were included in the study. Thrombosis and embolism were the cause of AMI in 48 patients (67%) and 24 patients (33%), respectively. Abdominal pain was the most common presenting symptom (96%), followed by nausea (56%). Preoperative angiogram was performed in 61 patients (85%). All patients underwent operative interventions, which included thromboembolectomy (n = 22, 31%), mesenteric bypass grafting (n = 33, 46%), patch angioplasty (n = 9, 12%), reimplantation (n = 5, 7%), and endarterectomy (n = 3, 4%). Bowel resection was necessary in 22 patients (31%) during the initial operation, and second-look operation was performed in 38 patients (53%). Perioperative morbidity and 30-day mortality rates were 39% and 31%, respectively. Univariate analysis showed renal insufficiency (P < .02), age >70 (P < .001), metabolic acidosis (P < .02), and symptom duration (P < .005), and bowel resection in second-look operations (P < .01) were associated with mortality. Logistic regression analysis showed age >70 (P = .03) and prolonged symptom duration (P = .02) were independent predictors of mortality. Conclusions: Elderly patients and those with a prolonged duration of symptoms had worse outcomes following surgical intervention for AMI. A high index of suspicion with prompt diagnostic evaluation may reduce time delay prior to surgical intervention, which may lead to improved patient survival. Aggressive surgical intervention should be performed as promptly as possible in patients once the diagnosis of AMI is made. © 2007 The Society for Vascular Surgery. AU - Kougias, Panagiotis AU - Lau, Donald AU - El Sayed, Hosam F. AU - Zhou, Wei AU - Huynh, Tam T. AU - Lin, Peter H. DO - 10.1016/j.jvs.2007.04.045 IS - 3 PY - 2007 SP - 467 EP - 474 TI - Determinants of mortality and treatment outcome following surgical interventions for acute mesenteric ischemia T2 - Journal of Vascular Surgery VL - 46 ER - TY - JOUR AU - del rio sola, M.L. AU - Gonzalez-fajardo, J.A. AU - Vaquero puerta, C. IS - 2 KW - isquemia intestinal PY - 2015 TI - Isquemia mesentérica aguda. Diagnóstico y tratamiento T2 - Angiologia VL - 67 ER - TY - JOUR AB - Intestinal ischemia includes all the conditions in which the blood supply to the gastrointestinal tract is not adequate to its metabolic demand. Several ischemic intestinal disorders differ in clinical presentation (acute versus chronic), etiology (occlusive versus nonocclusive), pathophysiology (arterial or venous), severity (mucosal versus transmural necrosis), and location (small bowel versus large bowel). Atherosclerosis, thromboembolic disease, hypoperfusion states, and hypercoagulable disorders are the most common causes. Reperfusion, oxygen-derived free radicals, and eicosanoids contribute to the pathogenesis of bowel injury and the systemic response that occur after ischemia. The diagnosis and treatment of intestinal ischemia are still challenging despite the advances of radiology, intensive care, and surgery. This article reviews the latest data about etiology and pathophysiology of bowel ischemia to explain the bases of diagnosis and treatment of this condition. © 2008 Elsevier Inc. All rights reserved. AU - Paterno, Flavio AU - Longo, Walter E. DO - 10.1016/j.rcl.2008.06.005 IS - 5 KW - Bowel ischemia KW - Intestinal ischemia KW - Ischemic colitis KW - Mesenteric infarction KW - Mesenteric ischemia PB - Elsevier Ltd PY - 2008 SP - 877 EP - 885 TI - The Etiology and Pathogenesis of Vascular Disorders of the Intestine T2 - Radiologic Clinics of North America UR - http://dx.doi.org/10.1016/j.rcl.2008.06.005 VL - 46 ER - TY - JOUR AB - Splanchnic vein thrombosis (SVT) is a broad term that includes Budd-Chiari syndrome and occlusion of veins that constitute the portal venous system. Due to the common risk factors involved in the pathogenesis of these clinically distinct disorders, concurrent involvement of two different regions is quite common. In acute and subacute SVT, the symptoms may overlap with a variety of other abdominal emergencies while in chronic SVT, the extent of portal hypertension and its attendant complications determine the clinical course. As a result, clinical diagnosis is often difficult and is frequently reliant on imaging. Tremendous improvements in vascular imaging in recent years have ensured that this once rare entity is being increasingly detected. Treatment of acute SVT requires immediate anticoagulation. Transcatheter thrombolysis or transjugular intrahepatic portosystemic shunt is used in the event of clinical deterioration. In cases with peritonitis, immediate laparotomy and bowel resection may be required for irreversible bowel ischemia. In chronic SVT, the underlying cause should be identified and treated. The imaging manifestations of the clinical syndromes resulting from SVT are comprehensively discussed here along with a brief review of the relevant clinical features and therapeutic approach. AU - Rajesh, S. AU - Mukund, Amar AU - Arora, Ankur DO - 10.1155/2015/101029 IS - Figure 2 PB - Hindawi Publishing Corporation PY - 2015 TI - Imaging Diagnosis of Splanchnic Venous Thrombosis T2 - Gastroenterology Research and Practice VL - 2015 ER - TY - JOUR AU - Singh, Manpreet AU - Koyfman, Alex AU - Martinez, Joseph P. DO - 10.1016/j.emc.2015.12.014 IS - 2 KW - Aorto-enteric fistula KW - Gastrointestinal bleeding KW - Mesenteric ischemia KW - Ruptured abdominal aortic aneurysm PB - Elsevier Inc PY - 2016 SP - 327 EP - 339 TI - Abdominal Vascular Catastrophes T2 - Emergency Medicine Clinics of North America UR - http://dx.doi.org/10.1016/j.emc.2015.12.014 VL - 34 ER - TY - JOUR AU - Rhee, Robert Y AU - Gloviczki, Peter DO - 10.1161/CIRCULATIONAHA.114.012871 IS - 18 PY - 2015 SP - 1599 EP - 1603 TI - Mesenteric venous thrombosis T2 - Circulation VL - 131 ER - TY - GEN TI - Acute Mesenteric Ischemia - StatPearls - NCBI Bookshelf UR - https://www.ncbi.nlm.nih.gov/books/NBK431068/ ER - TY - JOUR AB - The use of a central line or central venous catheterization was brought to attention in 1929 when Dr. Werner Forssmann self-inserted a ureteric catheter through his cubital vein and into the right side of his heart. Since that time the central line technique has developed further and has become essential for the treatment of decompensating patients. Central lines are widely used for anything from rapid fluid resuscitation, to drug administration, to parenteral nutrition, and even for administering hemodialysis. Central lines come in different sizes, types, and sites of administration. Sometimes their use can be associated with complications as well. The following review article addresses these parameters of central lines and goes into detail regarding their complications. AU - Patel, Avani R AU - Patel, Amar R AU - Singh, Shivank AU - Singh, Shantanu AU - Khawaja, Imran DO - 10.7759/cureus.4717 IS - 5 KW - bleeding KW - catheter knot KW - central line is often KW - central venous catheterization KW - complication KW - complications KW - crucial to the improvement KW - infection KW - insertion KW - introduction and background KW - of critically ill patients KW - pneumothorax KW - subclavian vein cannula KW - subclavian vein cannula insertion KW - the KW - the use of a PY - 2019 TI - Central Line Catheters and Associated Complications: A Review T2 - Cureus VL - 11 ER - TY - JOUR AB - Objective: To share with clinicians supporting evidence of the safest and the most effective processes for central venous catheter insertion and maintenance as a strategy to prevent catheter-associated bloodstream infections. Materials and Methods: A literature search was conducted in the Medline via PubMed, Embase Central and Lilacs databases based on a set of clinical questions aimed at improving safety and effectiveness at key moments in the process of central venous catheter insertion and maintenance. The rapid literature review methodology was used. The studies identified were assessed from the quality point of view, using the Joanna Briggs Institute (JBI) tools for qualitative and quantitative studies and for systematic reviews. Clinical practice guidelines were assessed using the AGREE II tool. The evidence is presented in the form of evidence-based clinical recommendations, which were graded in accordance with the JBI methodology. Results: Twelve clinical evidence summaries containing evidence related to the safe and effective use of central venous catheters are presented, including the following topics: central venous catheter insertion (CVC), peripherally inserted central catheters (PICC), preoperative assessment, the use of analgesia, field preparation, choice between CVC or PICC, CVC care and maintenance, prevention of complications, and general considerations pertaining to the use of central venous catheters in oncologic patients and in parenteral nutrition. Conclusions: Recommendations on the safe and effective use of central venous access catheters in relation to CVC insertion and maintenance processes are presented in the evidence-based summary model. It is necessary to evaluate their implementation in health outcomes in the institutions where they are developed. AU - Estrada-Orozco, Kelly AU - Cantor-Cruz, Francy AU - Larrotta-Castillo, Diego AU - Díaz-Ríos, Stefany AU - Ruiz-Cardozo, Miguel A. DO - 10.18597/RCOG.3413 IS - 2 KW - Bacteremia KW - Catheter-related infections KW - Clinical protocols KW - Patient safety KW - Safety measures PY - 2020 SP - 115 EP - 162 TI - Central venous catheter insertion and maintenance: Evidence-based clinical recommendations T2 - Revista Colombiana de Obstetricia y Ginecologia VL - 71 ER - TY - JOUR AB - Resumen El empleo de catéter venoso central en la práctica clínica ha surgido como una opción de acceso vascular en pacientes con estancias hospitalarias prolongadas por diversas patologías del nuevo espectro epidemiológico. Se le llama así a un acceso al torrente sanguíneo a nivel central, para la administración de medicamentos entre otras funciones. Existen varios tipos de catéter venoso central, dependiendo de la necesidad del paciente así se elige el indicado. Sin embargo, las infecciones por el uso de dichos instrumentos invasivos, así como otras complicaciones no infecciosas, divididas en inmediatas como lo son la punción arterial, el sangrado, neumotórax o hemotórax, arritmia, embolismo aéreo o malposición del catéter y complicaciones tardías entre estas la estenosis venosa, trombosis venosa, la migración de catéter, la perforación miocárdica o el daño nervioso plantean un nuevo reto para la medicina actual. Este artículo describe las complicaciones, el manejo respectivo de cada una y estrategias para reducir la incidencia de las mismas. Abstract The use of central venous catheter in clinical practice has emerged as a vascular access option in patients with prolonged hospital stays due to various pathologies of the new epidemiological spectrum. This is called an access to the bloodstream at the central level for the administration of medications and among other functions. There are several types of central venous catheters, depending on the patient's need so the one chosen is chosen. However, infections due to the use of such invasive instruments, as well as other non-infectious complications divided into immediate ones such as arterial puncture, bleeding, pneumothorax or hemothorax, arrhythmia, air embolism or catheter malposition and late complications between them venous AU - Carranza, A. García, aleria Caro AU - Cárdenas, Guiliana Quirós AU - José, María AU - Badilla, Monge AU - Quirós, Alejandra Arroyo AU - Alejandra, Dra AU - Carranza, García IS - 1 KW - bacteriemia KW - catéteres KW - catéteres venosos centrales KW - infecciones relacionadas con catéteres KW - prevención KW - secundaria PY - 2020 SP - 2020 EP - 2020 TI - Catéter venoso central y sus complicaciones Central Venous Catheter and its complications Palabras claves T2 - Revista Medicina Legal de Costa Rica UR - https://www.scielo.sa.cr/scielo.php?script=sci_arttext&pid=S1409-00152020000100074 VL - 37 ER - TY - JOUR AB - Cómo citar este artículo: Resumen Fundamento: En los últimos tiempos se está realizando con mayor frecuencia el acceso venoso por vía media con la técnica descrita por English, lo que supone menor riesgo de neumotórax y de punción arterial, además de su fácil realización. Objetivo: caracterizar el empleo del acceso venoso central por vía yugular media con uso de Seldinger en pacientes con enfermedades hematológicas y/o tratamiento con anticoagulantes. Métodos: estudio descriptivo, realizado desde enero a diciembre del 2009, en la Unidad Quirúrgica del Hospital de Cienfuegos. Se realizó cateterismo venoso central por vía media con la técnica de English a 47 pacientes con enfermedades hematológicas. Las variables analizadas fueron: número de intentos, indicaciones y complicaciones. Resultados: se obtuvo éxito en 43 accesos venosos centrales (91,48 %), de los cuales 35 se lograron al primer intento. En más de la mitad de los casos, la indicación fue el uso de citostáticos (55,31 %). Se observaron complicaciones en 5 pacientes, siendo la más frecuente la punción arterial (6,38 %). Conclusión: el acceso venoso central por vía media con Seldinger es una opción adecuada para pacientes con enfermedades hematológicas. En pacientes tratados con anticoagulantes minimiza las complicaciones. En general, es de fácil acceso y presenta un alto índice de éxito. Palabras clave: cateterismo venoso central, venas yugulares, anticoagulantes, neumotórax Abstract Background: In recent years, venous access via middle approach with the technique described by English has been frequently used, leading to lower risk of pneumothorax and arterial puncture. In addition, it is easy to perform. Objective: to characterize the performance of central venous access via the middle approach to the internal jugular vein using the Seldinger guidewire in patients with hematologic diseases and/or anticoagulant therapy. Methods: a descriptive study was conducted from January to December 2009 in the Surgical Unit of the Dr. Gustavo Aldereguía Lima University General Hospital in Cienfuegos. Central venous access via middle approach using the technique described by English was performed in 47 patients suffering from hematologic diseases. Variables analysed were: number of attempts, indications and complications. Results: 43 central venous catheterizations were successful (91.48 %), 35 of them were achieved in the first attempt. The use of cytostatics was indicated in more than half of the cases (55.31 %). Complications were observed in 5 patients; arterial puncture was the most common (6.38 %). Conclusions: central venous access via the middle approach using the Seldinger guidewire is a suitable option for patients with hematologic diseases. It minimizes complications in patients treated with anticoagulants. In general, it is easily accessible and has a high success rate. AU - Muñoz Cepero, Miguel AU - García Almeida, Asiris AU - Muñoz López, Lisandra IS - 4 KW - anticoagulantes KW - cateterismo venoso central KW - neumotórax KW - venas KW - yugulares PY - 2013 SP - 394 EP - 398 TI - Acceso venoso central por vía yugular media con uso de Seldinger T2 - MediSur VL - 11 ER - TY - JOUR AB - Antiseptics are chemical substances that when applied topically onto intact skin, mucous membranes or wounds partially or completely reduces the population of living microorganisms in those tissues. Different types of antiseptics are available - those most commonly used in clinical practice being alcohols, iodinated compounds and chlorhexidine. When using an antiseptic, consideration is required of its spectrum of antimicrobial activity, latency, residual effects, possible interferences of the presence of organic material with the activity of the antiseptic, its side effects, compatibility with other antiseptics, and cost. This article is part of a supplement entitled “Antisepsis in the critical patient”, which is sponsored by Becton Dickinson. AU - del Río-Carbajo, L. AU - Vidal-Cortés, P. DO - 10.1016/j.medin.2018.09.013 IS - xx KW - Alcohol KW - Antiseptics KW - Chlorhexidine KW - Iodinated compounds PB - Elsevier España, S.L.U. y SEMICYUC PY - 2019 SP - 7 EP - 12 TI - Types of antiseptics, presentations and rules of use T2 - Medicina Intensiva UR - https://doi.org/10.1016/j.medin.2018.09.013 VL - 43 ER - TY - JOUR AU - O'Grady, Naomi P. AU - Alexander, Mary AU - Burns, Lillian A. AU - Dellinger, E. Patchen AU - Garland, Jeffrey AU - Heard, Stephen O. AU - Lipsett, Pamela A. AU - Masur, Henry AU - Mermel, Leonard A. AU - Pearson, Michele L. AU - Raad, Issam I. AU - Randolph, Adrienne G. AU - Rupp, Mark E. AU - Saint, Sanjay AU - Healthcare Infection Control Practices Advisory Committee (HICPAC) DO - 10.1093/cid/cir257 IS - 9 PY - 2011 TI - Guidelines for the prevention of intravascular catheter-related infections. T2 - Clinical infectious diseases : an official publication of the Infectious Diseases Society of America VL - 52 ER - TY - JOUR AB - The use of central venous catheters (CVCs) in children is escalating, which is likely linked to the increased incidence of pediatric venous thromboembolism (VTE). In order to better understand the specific risk factors associated with CVC-VTE in children, as well as available prevention methods, a literature review was performed. The overall incidence of CVC-VTE was found to range from 0 to 74%, depending on the patient population, CVC type, imaging modality, and study design. Throughout the available literature, there was not a consistent determination regarding whether a particular type of central line (tunneled vs. non-tunneled vs. peripherally inserted vs. implanted), catheter material, insertion technique, or insertion location lead to an increased VTE risk. The patient populations who were found to be most at risk for CVC-VTE were those with cancer, congenital heart disease, gastrointestinal failure, systemic infection, intensive care unit admission, or involved in a trauma. Both mechanical and pharmacological prophylactic techniques have been shown to be successful in preventing VTE in adult patients, but studies in children have yet to be performed or are underpowered. In order to better determine true CVC-VTE risk factors and best preventative techniques, an increase in large, prospective pediatric trials needs to be performed. AU - Jaffray, Julie AU - Bauman, Mary AU - Massicotte, Patti DO - 10.3389/fped.2017.00005 IS - January KW - Central venous catheter KW - Pediatric KW - Peripherally inserted central catheter KW - Thromboprophylaxisl KW - Tunneled line KW - Venous thromboembolism KW - Venous thrombosis PY - 2017 SP - 1 EP - 6 TI - The impact of central venous catheters on pediatric venous thromboembolism T2 - Frontiers in Pediatrics VL - 5 ER - TY - JOUR AU - Galvis Rincón, Juan Carlos AU - Rojas Nayzir, Diana Marcela AU - Roa Páez, Sandra Carolina IS - 13 KW - calid KW - calidad de vida KW - changesinphysicalqualitiesandqualityoflifeafteraph KW - compliance and regulations of KW - diálisis renal KW - ejercicio KW - gjmr-f classification KW - insuficiencia renal crónica KW - nlmc code KW - strictly as per the KW - wb 460 PY - 2020 TI - Changes in Physical Qualities and Quality of Life after a Physical Conditioning Program in Hemodialysis Patients at the San José Renal Unit, Bogotá VL - 20 ER - TY - GEN AB - Resumen La Enfermedad Renal Crónica (ERC) es una entidad patológica progresiva no transmisible con múltiples enfermedades asociadas, principalmente cardiovasculares y diabetes Mellitus, aunque es prevenible, su ocurrencia incrementa mundialmente y Colombia no es la excepción. Su complejidad trae consigo tratamientos de larga duración y costos elevados, considerándose una enfermedad de alto costo para la salud pública del país. Tanto la enfermedad como los tratamientos sustitutivos incrementan condiciones limitantes de la función física restringiendo el desempeño en roles socioculturales y laborales. Entre los tratamientos no farmacológicos a nivel mundial se tiene la práctica de ejercicio físico antes o durante la hemodiálisis, sin embargo en Colombia no se reportan comunmente las intervenciones relacionadas con la práctica de ejercicio físico en pacientes con hemodiálisis de mantenimiento, razón por la que se diseña un programa de ejercicio físico basado en la evidencia a través de un estudio de tipo scoping review y posteriormente se realiza un panel de expertos en temáticas de ejercicio físico y ERC siguiendo el método Delphi, buscando una propuesta de intervención segura para los pacientes desde la evidencia y desde la experiencia de los expertos. Palabras clave: ejercicio físico, ejercicio intradialítico, hemodiálisis, Enfermedad Renal Crónica. AU - Cuasialpud Córdoba, Nathaly KW - Enfermedad Renal Crónica. KW - ejercicio físico KW - ejercicio intradialítico KW - hemodiálisis PY - 2020 SP - 107 EP - 107 TI - Diseño de un programa de ejercicio físico intradialítico basado en la Evidencia UR - https://repositorio.unal.edu.co/bitstream/handle/unal/75892/1020767467.2020.pdf?sequence=1&isAllowed=y ER - TY - GEN AU - Sutherland, Sheera IS - December PY - 2021 TI - Development of an acceptable, safe and feasible physical activity intervention for haemodialysis patients. UR - https://radar.brookes.ac.uk/radar/file/39726d9e-6166-40e9-a1f7-8323773087df/1/Development of an acceptable safe and feasible physical intervention for haemodialysis patients.pdf ER - TY - JOUR AB - Background/Aims: Scarce physical activity predicts shorter survival in dialysis patients. However, the relationship between physical (motor) fitness and clinical outcomes has never been tested in these patients. Methods: We tested the predictive power of an established metric of motor fitness, the Six-Minute Walking Test (6MWT), for death, cardiovascular events and hospitalization in 296 dialysis patients who took part in the trial EXCITE (ClinicalTrials.gov Identifier: NCT01255969). Results: During follow up 69 patients died, 90 had fatal and non-fatal cardiovascular events, 159 were hospitalized and 182 patients had the composite outcome. In multivariate Cox models - including the study allocation arm and classical and non-classical risk factors - an increase of 20 walked metres during the 6MWT was associated to a 6% reduction of the risk for the composite end-point (P=0.001) and a similar relationship existed between the 6MWT, mortality (P<0.001) and hospitalizations (P=0.03). A similar trend was observed for cardiovascular events but this relationship did not reach statistical significance (P=0.09). Conclusions: Poor physical performance predicts a high risk of mortality, cardiovascular events and hospitalizations in dialysis patients. Future studies, including phase-2 EXCITE, will assess whether improving motor fitness may translate into better clinical outcomes in this high risk population. AU - Torino, Claudia AU - Manfredini, Fabio AU - Bolignano, Davide AU - Aucella, Filippo AU - Baggetta, Rossella AU - Barillà, Antonio AU - Battaglia, Yuri AU - Bertoli, Silvio AU - Bonanno, Graziella AU - Castellino, Pietro AU - Ciurlino, Daniele AU - Cupisti, Adamasco AU - D'Arrigo, Graziella AU - De Paola, Luciano AU - Fabrizi, Fabrizio AU - Fatuzzo, Pasquale AU - Fuiano, Giorgio AU - Lombardi, Luigi AU - Lucisano, Gaetano AU - Messa, Piergiorgio AU - Rapanà, Renato AU - Rapisarda, Francesco AU - Rastelli, Stefania AU - Rocca-Rey, Lisa AU - Summaria, Chiara AU - Zuccalà, Alessandro AU - Tripepi, Giovanni AU - Catizone, Luigi AU - Zoccali, Carmine AU - Mallamaci, Francesca DO - 10.1159/000355798 KW - Chronic kidney disease KW - Clinical outcomes KW - Dialysis KW - Physical performance KW - Six-minute walking test PY - 2014 SP - 205 EP - 211 TI - Physical performance and clinical outcomes in dialysis patients: A secondary analysis of the excite trial EXCITE working group T2 - Kidney and Blood Pressure Research VL - 39 ER - TY - JOUR AB - Background: Hemodialysis patients are suffering from depressive symptoms. Brain-de-rived neurotrophic factor (BDNF) levels are negatively associated with depressive symptoms and decrease during a single hemodialysis session. Resistance training (RT) might be an additional non-pharmacological tool to increase BDNF and promote mental health. Methods: Two randomized groups of hemodialysis patients: control (CTL, n = 76/F36; 66.33 ± 3.88 years) and RT (n = 81/F35; 67.27 ± 3.24 years). RT completed six months of training thrice a week under the supervision of strength and conditioning professional immediately before the dialysis session. Training loads were adjusted using the OMNI rating of perceived exertion. The total antioxidant capacity (TROLOX), glutathione (GSH), thiobarbituric acid reactive substance (TBARS), and BDNF levels were analyzed in serum samples. Quality of life (assessed through Medical Outcomes—SF36), and Beck Depression Inventory was applied. Results: RT improved handgrip strength (21.17 ± 4.38 vs. 27.17 ± 4.34; p = 0.001) but not for CTL (20.09 ± 5.19 vs. 19.75 ± 5.54; p = 0.001). Post-training, RT group had higher values as compared to CTL related to TROLOX (RT, 680.8 ± 225.2 vs. CTL, 589.5 ± 195.9; p = 0.001) and GSH (RT, 9.33 ± 2.09 vs. CTL,5.00 ± 2.96; p = 0.001). RT group had lower values of TBARS as compared to CTL at post-training (RT, 11.06 ± 2.95 vs. CTL, 13.66 ± 2.62; p = 0.001). BDNF increased for RT (11.66 ± 5.20 vs. 19.60 ± 7.23; p = 0.001), but decreased for CTL (14.40 ± 4.99 vs. 10.84 ± 5.94; p = 0.001). Quality of life and mental health increased (p = 0.001) for RT, but did not change for CTL (p = 0.001). BDNF levels were associated with emotional dimensions of SF36, depressive symptoms, and handgrip (p = 0.001). Conclusions: RT was effective as a non-pharmacological tool to increased BDNF levels, quality of life, temper the redox balance and decrease depressive symptoms intensity in hemodialysis patients. AU - Deus, Lysleine Alves AU - Corrêa, Hugo de Luca AU - Neves, Rodrigo Vanerson Passos AU - Reis, Andrea Lucena AU - Honorato, Fernando Sousa AU - Silva, Victor Lopes AU - Souza, Michel Kendy AU - de Araújo, Thaís Branquinho AU - de Gusmão Alves, Lucas Santos AU - Sousa, Caio Victor AU - Reis, Thaís Lucena AU - de Aguiar, Lucas Soares AU - Simões, Herbert Gustavo AU - Prestes, Jonato AU - Melo, Gislane Ferreira AU - Rosa, Thiago Santos DO - 10.3390/ijerph182111299 IS - 21 KW - Depression KW - Neuroprotection KW - Quality of life KW - Redox balance KW - SF-36 PY - 2021 SP - 1 EP - 13 TI - Are resistance training-induced BDNF in hemodialysis patients associated with depressive symptoms, quality of life, antioxidant capacity, and muscle strength? An insight for the muscle–brain–renal axis T2 - International Journal of Environmental Research and Public Health VL - 18 ER - TY - JOUR AB - Physical inactivity is a determinant of clinical disorders and psychological problems in patients with chronic kidney disease patients. In two satellite clinics, a program of physical activity (PA) was offered to 86 patients undergoing hemodialysis. Of those, 49 patients entered the PA program spontaneously and 37 remained inactive. After six months, a satisfaction self-reported questionnaire and the Modified Mini-Mental State (3MS) Examination for assessment of cognitive function were applied. Cognition was compared between inactive patients and those participating in the PA program for at least three months. Regardless of age and duration of dialysis, patients showed a cognitive deficit greater than expected. In the general group, better cognitive function was observed in active patients as compared to the inactive ones (p < 0.05). When separated by age groups, active patients over the age of 60 years had better results than the inactive ones (p < 0.05). We concluded that patients with better cognitive responses are more physically active and/or physical activity contributes to better cognitive function. AU - Martins, Carmen Tzanno Branco AU - Ramos, Geison Stein Meirelles AU - Guaraldo, Simone Adriana AU - Uezima, Clarissa Baia Bargas AU - Martins, João Paulo Lian Branco AU - Ribeiro Junior, Elzo DO - 10.1590/s0101-28002011000100003 IS - 1 KW - and training KW - chronic kidney failure KW - cognition KW - physical educational KW - renal PY - 2011 SP - 27 EP - 30 TI - Comparison of cognitive function between patients on chronic hemodialysis who carry out assisted physical activity and inactive ones. T2 - Jornal brasileiro de nefrologia : orgão oficial de Sociedades Brasileira e Latino-Americana de Nefrologia VL - 33 ER - TY - JOUR AB - BACKGROUND: There are still many barriers when implementing exercise routines within daily dialysis care, even though benefits are well-known. developing cost-effective strategies is necessary to overcome these barriers and include exercise as a complementary therapy in dialysis. aiM: to compare several exercise programs on hemodialysis patient’s functional capacity and health-related quality of life. dEsiGn: this study was a 16-week follow-up, two-parallel group trial with balanced randomization. sEttinG: participants in this study belonged to a private hospitalized care center. population: referred sample of 71 patients that suffered end-stage chronic kidney disease who underwent hemodialysis for at least 3 months and had a medical stable condition. MEthods: thirty-six participants performed for 16 weeks an intradialytic exercise program lead by the nursing staff of the hemodialysis unit and 35 a home-based program supervised by physical therapists of the hospital. RESULTS: The main researcher and the data analyst were both blinded to participant allocation. There was a significant effect in time for both groups. Participants improved significantly in the Short Performance Physical Battery (SPPB), One-Leg Heel-Rise (OLHR) and 6 Minute-Walk Test (6MWT), and in the Physical Activity Scale for the Elderly (PASE) and Short Survey Form 36 (SF-36) questionnaires. CONCLUSIONS: Nurse-led and home-based exercise interventions produce beneficial effects involving physical function, activity levels and health-related quality of life in patients undergoing hemodialysis. clinical rEhabilitation iMpact: the study emphasizes the importance of exercise rehabilitation routines in fragile populations such as dialysis patients, and the potential to overcome barriers for its daily implementation. AU - Perez-Dominguez, Borja AU - Casaña-Granell, Jose AU - Garcia-Maset, Rafael AU - Garcia-Testal, Alicia AU - Melendez-Oliva, Erika AU - Segura-Orti, Eva DO - 10.23736/s1973-9087.21.06694-6 IS - 6 KW - Dialysis KW - Exercise KW - Rehabilitation PY - 2021 SP - 994 EP - 1001 TI - Effects of exercise programs on physical function and activity levels in patients undergoing hemodialysis: a randomized controlled trial T2 - European Journal of Physical and Rehabilitation Medicine VL - 57 ER - TY - JOUR AB - Purpose: To investigate the impact of intradialytic progressive resistance exercise (IPRE) on physical fitness and quality of life in maintenance haemodialysis (MHD) patients. Methods: Subjects were allocated randomly to the exercise group received IPRE and the control group underwent a haemodialysis session alone. Outcomes measured were including physical fitness ascertained by 6-min walk test, sit-to-stand 10 test and handgrip strength. Kidney Disease Quality of Life Instrument was used to assess the quality of life, and also recorded the adverse event at each exercise session. Results: A total of 87 patients were analysed: 43 in the exercise group and 44 in the control group. After 12 weeks, there were significant improvements in physical fitness and past of the dimension of the scale in the exercise group. Conclusions: IPRE can improve the physical fitness and quality of life in patients underwent MHD with no serious adverse events or safety issues. AU - Zhang, Fan AU - Huang, Liuyan AU - Wang, Weiqiong AU - Shen, Qiyun AU - Zhang, Huachun DO - 10.1002/nop2.585 IS - 6 KW - exercise KW - fitness KW - haemodialysis KW - nurses KW - nursing KW - quality of life PY - 2020 SP - 1945 EP - 1953 TI - Effect of intradialytic progressive resistance exercise on physical fitness and quality of life in maintenance haemodialysis patients T2 - Nursing Open VL - 7 ER - TY - GEN AU - Krase, Argyro PY - 2019 SP - 1 EP - 140 TI - The effect of exercise rehabiliation regimes in combination with changes in dialysis procedures in aspects related to quality of life and health in end stage renal disease patients ER - TY - JOUR AB - Intradialytic cycling is a widely used workout mode, whereas added benefit of other exercise modalities remains unknown. This is the first randomised controlled trial on the effects and sustainability of functional training and counselling in addition to intradialytic cycling. Patients were randomly assigned to a kinesiologist-guided functional training in addition to intradialytic cycling (n = 20, experimental group) or intradialytic cycling only (n = 20, control group) over 16 weeks. The experimental group attended predialysis functional exercise in the first eight weeks and afterward performed functional training at home for the next eight weeks. The primary study endpoint was 10-repetition-sit-to-stand test time at eight weeks: at this test, the experimental group improved significantly better than controls (−4.5 ± 1.9 s, 95%CI −8.4 to −0.7; P = 0.021), which was maintained at week 16 (−4.7 ± 2.1 s, 95%CI −9.0 to −0.3; P = 0.037). At week 8, the experimental group significantly outperformed controls also at handgrip strength (P = 0.004), lower body flexibility test (P < 0.001), balance test (P < 0.001), and upper body flexibility test (P = 0.003). At week 16, superior results of the experimental group in secondary end-points remained preserved for handgrip strength, balance, and upper body flexibility tests. Functional training with exercise counselling meaningfully improves physical performance and successfully prepares patients for sustainable home exercise. AU - Bogataj, Špela AU - Pajek, Jernej AU - Buturović Ponikvar, Jadranka AU - Hadžić, Vedran AU - Pajek, Maja DO - 10.1038/s41598-020-62709-1 IS - 1 PY - 2020 SP - 1 EP - 10 TI - Kinesiologist-guided functional exercise in addition to intradialytic cycling program in end-stage kidney disease patients: a randomised controlled trial T2 - Scientific Reports VL - 10 ER - TY - GEN AU - Gregg, Donny francis IS - May PY - 2018 TI - Effects of exercise aining on skeletal muscle health in elderly dialysis patients ER - TY - JOUR AB - Exercise as a therapeutic tool used in End-stage renal disease patients (ESRD) in hemodialysis (HD) is not routinately applied, as it occurs with cardiac or respiratory patients. Lack of awareness of research in this field may contribute to the current situation. Thus, the aims of this review are: 1) to systematically review the literature of exercise training on adult HD patients or patients at a pre-HD stage; 2) to show the evidence on the benefits of exercise for counteracting physiological, functional and psychological impairments found even in older ESRD patients; 3) to recommend requirements of future research in order to include exercise prescription in the HD patients treatment. The Data bases reviewed from 2005 to 2009 were: MEDLINE (Ovid), CINAHL (EBSCOHost), SportDicus (EBSCOHost), Academic Search Complete (EBSCOHost), Fuente Académica (EBSCOHost), MedicLatina (EBSCOHost), PEDro y PubMed. Additionally, references from identified articles, several reviews on ESRD and abstracts to Nephrology Congresses were also reviewed. Randomized Controlled Trials on aerobic, strength and combined programs for HD patients were selected. Data from the studies was compiled and Van Tulder criteria were used for methodological quality assessment. Metanalysis included 6 studies on aerobic exercise, 2 on strength exercise and 5 on combined exercise programs. 640 patients were included in 16 included studies. Effects on physical function, health related quality of life and other secondary measurements were summarized by the Standardized Mean Difference (SMD) Moderate evidence exists on positive effects of aerobic training on peak oxygen consumption at the graded exercise test (SMD 6.55; CI 95%: 4.31-8.78). There is high evidence on positive effects of strength training on health related quality of life (SMD 11.03; CI 95%: 5.63-16.43). Finally, moderate evidence exists on positive effects of combined exercise on peak oxygen consumption at the graded exercise test (SMD 5.57; CI 95%: 2.52-8.61). Summarizing, moderate evidence exists on the improvement on exercise capacity of aerobic training, isolated or combined with strength training. Strength training improves health related quality of life, functional capacity and lower limbs strength. Future studies should clarify which out of the three modalities results in higher benefits for HD patients. AU - Segura-Ortí, Eva DO - 10.3265/Nefrologia.pre2010.Jan.10229 IS - 2 KW - Exercise KW - Hemodialysis KW - Metanalysis KW - Review PY - 2010 SP - 236 EP - 246 TI - Ejercicio en pacientes en hemodiálisis: Revisión sistemática de la literatura T2 - Nefrologia VL - 30 ER - TY - JOUR AB - Purpose: To assess physical activity, and its associations with health, clinical, and biochemical factors, in patients with stages 2-4 of chronic kidney disease (CKD). Methods: Cross-sectional data were collected from 120 patients with CKD enrolled in the Lipid lowering and Onset of Renal Disease (LORD) trial. Patients with serum creatinine levels >120 μmol L-1 were included, and those taking lipid-lowering medication were among those excluded. Self-report questionnaires were used to assess physical activity (Active Australia) and health (SF-36). A cutoff of 600 MET min wk-1 was used to determine those meeting national activity guidelines. Clinical and biochemical data included renal function, medications, an index of coexistent disease, lipid levels, dietary intake, liver enzymes, and full blood count measures. Univariate and multivariate analyses were used to examine associations between physical activity and health, clinical, and biochemical data. Results: Fifty percent of patients met activity guidelines, and 9% (n = 11) reported no physical activity. Patients who met the guidelines were very active, completing on average more than 2400 METIminIwkj1, predominantly achieved by walking. Patients with CKD had lower SF-36 physical component summary scores compared with a reference population; however, none of the SF-36 physical functioning measures were associated with physical activity levels or meeting activity guidelines. Conclusion: Many patients with stages 2-4 of CKD are meeting, and exceeding, recommended levels of physical activity, indicating that CKD is not necessarily a limitation to activity. Copyright © 2009 by The American College of Sports Medicine. AU - Fassett, Robert G. AU - Robertson, Iain K. AU - Geraghty, Dominic P. AU - Ball, Madeleine J. AU - Burton, Nicola W. AU - Coombes, Jeff S. DO - 10.1249/MSS.0b013e3181940aef IS - 5 KW - Active Australia KW - MET-min·wk -1 KW - Renal disease KW - Self-reported health PY - 2009 SP - 985 EP - 991 TI - Physical activity levels in patients with chronic kidney disease entering the LORD trial T2 - Medicine and Science in Sports and Exercise VL - 41 ER - TY - JOUR AB - Regular physical activity is associated with an increased quality of life and reduced morbidity and mortality in the general population and in patients with chronic kidney disease (CKD). Physical activity, cardiorespiratory fitness, and muscle mass decrease even in the early stages of CKD, and continue to decrease with disease progression; notably, full recovery is generally not achieved with transplantation. The combined effects of uraemia and physical inactivity drive the loss of muscle mass. Regular physical activity benefits cardiometabolic, neuromuscular and cognitive function across all stages of CKD, and therefore provides an approach to address the multimorbidity of the CKD population. Interestingly, maintenance of muscle health is associated with renoprotective effects. Despite evidence of its benefits, physical activity and exercise management are not routinely addressed in the care of these patients. Although studies defining the optimum frequency, duration and intensity of physical activity are lacking, evidence from related fields can guide practical approaches to the care of patients with renal disease. Optimization of metabolic and nutritional status alongside promotion of physical activity is recommended. Behavioural approaches are now recognized as crucial in helping patients to adopt lifestyle changes and might prove valuable in integrating physical activity into renal care. AU - Zelle, Dorien M. AU - Klaassen, Gerald AU - Van Adrichem, Edwin AU - Bakker, Stephan J.L. AU - Corpeleijn, Eva AU - Navis, Gerjan DO - 10.1038/nrneph.2016.187 IS - 3 PB - Nature Publishing Group PY - 2017 SP - 152 EP - 168 TI - Physical inactivity: A risk factor and target for intervention in renal care T2 - Nature Reviews Nephrology UR - http://dx.doi.org/10.1038/nrneph.2016.187 VL - 13 ER - TY - GEN AB - Objetivo: Sistematizar las evidencias sobre un programa de entrenamiento físico para mejorar la fuerza muscular en los pacientes adultos en hemodiálisis. Materiales y Métodos: El presente trabajo de investigación es una revisión sistemática que incluyo 10 artículos no mayor de diez años publicados en inglés y español, de las cuales fueron seleccionados en la base de datos: Scielo, KJIM, Elsevier, Science Scientific Journal, cual tema principal fue la fuerza física para mejorar la fuerza muscular.Resultados: De los 10 artículos científicos analizados detalladamente ,9 de ellas muestran que un programa de entrenamiento físico a través de ejercicios aeróbicos y ejercicios anaeróbico mejoran la fuerza muscular de los pacientes que reciben hemodiálisis.Conclusiones: un programa de entrenamiento físico mejora la fuerza muscular en los pacientes que reciben terapia dialítica de hemodiálisis, de esta manera podemos prevenir el deterioro físico y contribuir a una mejor calidad de vida AU - Escobar Calderon, Elena AU - Ramos Bazan, Amparo KW - ejercicios físicos. KW - fuerza física KW - fuerza muscular PY - 2020 SP - 1 EP - 36 TI - Efectividad de un programa de entrenamiento físico para mejorar la fuerza muscular de los pacientes adultos en Hemodiálisis UR - http://repositorio.uwiener.edu.pe/handle/123456789/3733 ER - TY - JOUR AU - Foundation, National Kidney DO - 10.1053/j.ajkd.2005.01.019 IS - 4 Suppl 3 PY - 2005 SP - 16 EP - 153 TI - K/DOQI clinical practice guidelines for cardiovascular disease in dialysis patients. T2 - American journal of kidney diseases : the official journal of the National Kidney Foundation VL - 45 ER - TY - JOUR AB - Background: Chronic kidney disease (CKD) is associated with an increased risk of fracture. Decreased bone mass and disruption of microarchitecture occur early in the course of CKD and worsens with the progressive decline in renal function so that at the time of initiation of dialysis at least 50% of patients have had a fracture. Despite the excess fracture risk, and the associated increases in morbidity and mortality, little is known about the factors that are associated with an increase in fracture risk. Our study aims to identify prognostic factors for bone loss and fractures in patients with stages 3 to 5 CKD. Methods: This prospective study aims to enroll two hundred and sixty men and women with stages 3 to 5 CKD. Subjects will be followed for 24 months and we will examine the ability of: 1) bone mineral density by dual x-ray absorptiometry at the spine, hip, and radius; 2) volumetric bone density by high resolution peripheral quantitated computed tomography at the radius and tibia; 3) serum markers of bone turnover; 4) bone formation rate by bone biopsy; and 5) muscle strength and balance to predict spine and non-spine fractures, identified by self-report and/or vertebral morphometry. All measurements will be obtained at baseline, at 12 and at 24 months with the exception of bone biopsy, which will be measured once at 12 months. Subjects will be contacted every 4 months to determine if there have been incident fractures or falls. Discussion: This study is one of the first that aims to identify risk factors for fracture in early stage CKD patients. Ultimately, by identifying risk factors for fracture and targeting treatments in this group-before the initiation of renal replacement therapy-we will reduce the burden of disease due to fractures among patients with CKD. © 2010 West et al; licensee BioMed Central Ltd. AU - West, Sarah L. AU - Lok, Charmaine E. AU - Jamal, Sophie A. DO - 10.1186/1471-2369-11-17 IS - 1 PY - 2010 TI - Fracture risk assessment in chronic kidney disease, prospective testing under real world environments (FRACTURE): A prospective study T2 - BMC Nephrology VL - 11 ER - TY - JOUR AB - Background. Urea rebound results as urea re-equilibrates between intracellular and intravascular compartments post haemodialysis. The mechanism of the rebound is thought to be due to either a reduced diffusion rate or blood flow. It is hypothesized that low blood flow in the skeletal muscles might be responsible. We tested this by studying the effect of exercise during dialysis on the removal of urea, creatinine and potassium. Methods. Eleven patients (aged 32-78 years) on haemodialysis (4-58 months) were studied on paired dialysis sessions; one with exercise and the other as a control. Patients pedalled on a cycle for 5-20 min at submaximal workload followed by 10 min rest to achieve a total of 60 min exercise. Plasma concentrations of urea, creatinine and potassium were measured pre-, post- and 30-min post dialysis. The post-dialysis rebound (% rebound) and reduction ratios (RR) of the solutes and equilibrated (two-pool) urea Kt/V were calculated for comparison. Results. The rebound of all three solutes was reduced significantly following exercise. The rebound of urea decreased from 12.4 to 10.9% (median, P < 0.01 Wilcoxon signed rank test), creatinine from 21.2 to 17.2% (P < 0.001) and potassium from 62 to 44% (P < 0.05). Kt/V and RR increased significantly as a result: Kt/V urea from 1.00 to 1.15 (P = 0.001), RR urea from 0.63 to 0.68 (P < 0.001); Kt/V creatinine from 0.71 to 0.84 (P < 0.01); and RR creatinine from 0.51 to 0.57 (P < 0.05). Conclusion. Exercise increased the efficiency of dialysis by reducing the rebound of solutes due to increased perfusion of the skeletal muscles. AU - Kong, Chiew H. AU - Tattersall, James E. AU - Greenwood, Roger N. AU - Farrington, Ken DO - 10.1093/ndt/14.12.2927 IS - 12 KW - Blood flow KW - Diffusion rate KW - Exercise KW - Haemodialysis KW - Solute removal KW - Urea rebound PY - 1999 SP - 2927 EP - 2931 TI - The effect of exercise during haemodialysis on solute removal T2 - Nephrology Dialysis Transplantation VL - 14 ER - TY - JOUR AB - Introduction: Chronic kidney disease (CKD) is a general term for heterogeneous disorders that affect the structure and function of the kidney. Complications of CKD significantly limit exercise (Ex) tolerance by reducing functional capacity, endurance, and strength. However, the practice of regular Ex contributes to delaying the progression of CKD and stimulating improvements in health-related quality of life (HRQOL). Ex performed during the period of hemodialysis may be the best option when stimulating adherence and being under medical supervision. The purpose of the paper is to examine the effectiveness of intradialytic (iHD) Ex on health outcomes in patients with CKD by identifying the most appropriate component of Ex. Material and method: Systematic review, based on PRISMA guidelines, performing a structured search in Medline, SciELO and Cochrane Library Plus databases. Publications from the last 5 years relating iHD Ex and CKD up to 31 December 2019 were included. The methodological quality of the articles was evaluated using the McMaster critical review form. Results: We found 7 articles that described increases in endurance, upper and lower limb muscle strength, and HRQL of CKD patients providing emotional, social and psychological improvements. In addition, iHD Ex is able to control oxidative stress, inflammation, improve the lipid profile and stimulate endothelial progenitor cells, which together reduce the risk of mortality associated with multiple comorbidities in CKD patients, especially cardiovascular ones. Conclusions: Ex provides improvements in physical function and capacity, HRQL and biological markers. Aerobic Ex, muscle strength Ex and combined Ex programs are used. AU - Fernández-Lázaro, Diego AU - Mielgo-Ayuso, Juan AU - Lázaro Asensio, María Paz AU - Martínez, Alfredo Córdova AU - Caballero-García, Alberto AU - Fernández-Lázaro, César I. DO - 10.18176/ARCHMEDDEPORTE.00017 IS - 6 KW - Biomarkers KW - Chronic renal disease KW - Health-related quality of life KW - Hemodialysis KW - Physical capacity KW - Physical exercise PY - 2020 SP - 419 EP - 429 TI - Intradialytic physical exercise in chronic kidney disease: A systematic review of health outcomes T2 - Archivos de Medicina del Deporte VL - 37 ER - TY - JOUR AB - Patients with CKD are characterized by low levels of physical functioning, which, along with low physical activity, predict poor outcomes in those treated with dialysis. The hallmark of clinical care in geriatric practice and geriatric research is the orientation to and assessment of physical function and functional limitations. Although there is increasing interest in physical function and physical activity in patients with CKD, the nephrology field has not focused on this aspect of care. This paper provides an in-depth review of the measurement of physical function and physical activity. It focuses on physiologic impairments and physical performance limitations (impaired mobility and functional limitations). The review is based on established frameworks of physical impairment and functional limitations that have guided research in physical function in the aging population. Definitions and measures for physiologic impairments, physical performance limitations, self-reported function, and physical activity are presented. On the basis of the information presented, recommendations for incorporating routine assessment of physical function and encouragement for physical activity in clinical care are provided. © 2013 by the American Society of Nephrology. AU - Painter, Patricia AU - Marcus, Robin L. DO - 10.2215/CJN.06590712 IS - 5 PY - 2013 SP - 861 EP - 872 TI - Assessing physical function and physical activity in patients with CKD T2 - Clinical Journal of the American Society of Nephrology VL - 8 ER - TY - JOUR AU - Johansen, L, Kirsten AU - Chertow, Glenn AU - Kutner, Nacy AU - Dalrymple, Lorien S. AU - Grimes, Barbara AU - Kaysen, George DO - 10.1038/ki.2010.312.Low IS - 11 KW - epiblast KW - gfp fusion KW - histone h2b- KW - icm KW - lineage specification KW - live imaging KW - mouse blastocyst KW - pdgfr α KW - primitive endoderm PY - 2010 SN - 6176321972 SP - 1164 EP - 1170 TI - Low level of self-reported physical activity in ambulatory patients new to dialysis T2 - Kidney Int. VL - 78 ER - TY - JOUR AB - Although physical activity is recommended in patients on maintenance hemodialysis (MHD), randomized controlled trials testing the effects of exercise in this population have given conflicting results. In general, aerobic exercises mostly failed to produce improvements in physical function, whereas resistance exercises, although less studied, appeared to be more promising. The use of sophisticated materials such as leg press and free weights may preclude widespread application of resistance training in patients on MHD. Simple and cheap elastic bands may thus be an attractive alternative. We tested the feasibility of a supervised intradialytic resistance band exercise training program, and its effects on physical function, in patients on MHD.A total of 11 unselected adult patients on MHD from our center, aged 70 ± 10.7 (mean ± standard deviation) years, including 8 men and 3 women, accepted to follow the program under the supervision of qualified physiotherapists. Thirty-six exercise sessions of moderate intensity (twice a week, mean duration 40 minutes each, during 4.5 to 6 months), mainly involving leg muscles against an elastic resistance, were performed.The exercise program was well tolerated and all patients completed it. Statistically significant improvements were observed in the following tests: Tinetti test, 23.9 ± 3.9 points before versus 25.7 ± 3.5 points after the program (P = .022); the Timed Up and Go test, 12.1 ± 6.6 versus 10 ± 5.8 seconds (P = .0156). Improvements in the 6-minute walk distance and in the one-leg balance tests just failed to reach statistical significance.In this single-center pilot study, an intradialytic resistance band exercise program was feasible, well tolerated, and showed encouraging results on physical function. © 2011 National Kidney Foundation, Inc. AU - Bullani, Roberto AU - El-Housseini, Youssef AU - Giordano, Fabrice AU - Larcinese, Anna AU - Ciutto, Lorella AU - Bertrand, Pauline Coti AU - Wuerzner, Grégoire AU - Burnier, Michel AU - Teta, Daniel DO - 10.1053/j.jrn.2010.10.011 IS - 1 PY - 2011 SP - 61 EP - 65 TI - Effect of intradialytic resistance band exercise on physical function in patients on maintenance hemodialysis: A pilot study T2 - Journal of Renal Nutrition VL - 21 ER - TY - JOUR AB - Parsons TL, Toffelmire EB, King-VanVlack CE. Exercise training during hemodialysis improves dialysis efficacy and physical performance. Objective: To determine the impact of a 20-week intradialytic exercise program, consisting of 60 minutes of cumulative duration, low-intensity exercise during the first 2 hours of dialysis, on dialysis efficacy, physical performance, and quality of life in self-care hemodialysis (HD) patients. Design: One-group repeated measures. Setting: Satellite HD units affiliated with a Canadian teaching hospital. Participants: A convenience sample of 13 self-care HD patients who were stable on dialysis for a minimum of 6 months and were medically screened for significant cardiac, pulmonary, and/or musculoskeletal pathology that would preclude exercise. Intervention: A 5-month intradialytic exercise program in which subjects exercised 3 times a week (cycle ergometer, mini-stepper) for 30 minutes in each of the first 2 hours of HD. Main Outcome Measures: Dialysis efficacy (in single-pool model of urea kinetics [spKt/V]) was assessed prior to and at the end of each month of the exercise program. Physical function (6-minute walk test [6MWT]), and quality of life. (Kidney Disease Quality of Life-Short Form [KDQOL]) were determined at baseline and at weeks 10 and 20 of the exercise program. Results: SpKt/V increased 11% at the end of the first month of the program (P<.05) and remained elevated for the duration of the program (18%-19%). Distance walked on the 6MWT increased by 14% at both weeks 10 and 20 (P<.05). No changes were noted in KDQOL scores. Conclusions: A low-intensity intradialytic exercise program is a viable adjunctive therapy, which improves HD efficacy and physical function in HD patients. © 2006 American Congress of Rehabilitation Medicine and the American Academy of Physical Medicine and Rehabilitation. AU - Parsons, Trisha L. AU - Toffelmire, Edwin B. AU - King-VanVlack, Cheryl E. DO - 10.1016/j.apmr.2005.12.044 IS - 5 KW - Exercise KW - Hemodialysis KW - Quality of life KW - Rehabilitation KW - Urea PY - 2006 SP - 680 EP - 687 TI - Exercise Training During Hemodialysis Improves Dialysis Efficacy and Physical Performance T2 - Archives of Physical Medicine and Rehabilitation VL - 87 ER - TY - JOUR AU - Quiroz-figueroa, Martha Saida AU - Piguave-figueroa, Tatiana Jazmin DO - 10.23857/pc.v6i2.2292 IS - 2 PY - 2021 SP - 607 EP - 617 TI - Autocuidado y calidad de vida en pacientes renales con tratamiento de hemodiálisis Self-care and quality of life in kidney patients with hemodialysis treatment Autocuidado e qualidade de vida em pacientes renais em tratamento de hemodiálise VL - 6 ER - TY - JOUR AU - Almanza, Allison AU - Giusiano, Pebbles AU - Martincorena, Natalia AU - Brites, Pablo IS - 1 KW - restricción de PY - 2022 SP - 11 EP - 21 TI - Efectos del entrenamiento físico con restricción del flujo vascular durante la hemodiálisis Effects of physical training with vascular flow restriction during VL - 42 ER - TY - JOUR AU - F., Shiraishi IS - June PY - 2010 TI - Physical Fitness Improves Arterial Stiffness in Patients T2 - Journal of Hypertension VL - 28 ER - TY - JOUR AB - En mayo de 2004, la 57ª Asamblea Mundial de la Salud aprobó la Estrategia Mundial de la Organización Mundial de la Salud sobre Régimen Alimenta- rio, Actividad Física y Salud. La Estrategia se elaboró sobre la base de una amplia serie de consultas con todas las partes interesadas, en respuesta a la petición que formularon los Estados Miembros en la Asamblea Mundial de la Salud celebrada en 2002 (resolución WHA55.23). En el presente documento figuran la mencionada Estrategia y la resolución mediante la que se aprobó (WHA57.17). AU - Organización Mundial de la Salud IS - 4 PY - 2004 SN - 92 4 359222 X SP - 24 EP - 24 TI - Estrategia mundial sobre régimen alimentario, actividad física y salud T2 - Nutricion Clinica y Dietetica Hospitalaria VL - 1 ER - TY - JOUR AB - This chapter focuses on the environmental habitats of the dominant human-pathogenic species, Cryptococcus neoformans and Cryptococcus gattii, and their varieties and subgroups. The procedures for isolating C. gattii from any environmental sample are the same as those for C. neoformans. Several researchers have sampled specific sites temporally and spatially. Many have included a variety of telluric, arboreal, aquatic, and aerial niches. C. neoformans was recovered from 62 samples of decayed wood from the hollows of five pink shower trees, two fig trees, and one November shower tree. The majority of patients diagnosed with cryptococcal meningitis in Teresina resided in Piauḭ or the adjacent state of Maranhão. Strains of VNI can readily be isolated from pigeon feces, and they are able to grow and mate on media containing pigeon feces. As cited in the chapter, the rare environmental strains of VNII have included isolations from pigeon and arboreal habitats, but their numbers have been too low to define the ecological niche of this molecular type. C. gattii is rarely isolated from pigeon feces but is associated with various tree species in Australia, Asia, North America, and South America. These different environmental niches have led to the hypothesis that C. neoformans is ubiquitous in the environment due to dissemination by pigeons following migratory and trade routes and that C. gattii is restricted to tropical and subtropical regions because it is not associated with pigeons. AU - Mitchell, Thomas G. AU - Castañeda, Elizabeth AU - Nielsen, Kirsten AU - Wanke, Bodo AU - Lazéra, Marcia S. DA - 2014/4// DO - 10.1128/9781555816858.CH18 KW - Cryptococcus gattii KW - Cryptococcus neoformans KW - environmental isolation KW - environmental niches KW - environmental sources KW - geographical distribution PB - John Wiley & Sons, Ltd PY - 2014 SP - 235 EP - 259 TI - Environmental Niches for Cryptococcus neoformans and Cryptococcus gattii T2 - Cryptococcus UR - https://onlinelibrary.wiley.com/doi/full/10.1128/9781555816858.ch18 UR - https://onlinelibrary.wiley.com/doi/abs/10.1128/9781555816858.ch18 UR - https://onlinelibrary.wiley.com/doi/10.1128/9781555816858.ch18 ER - TY - JOUR AB - The Cryptococcus gattii species complex has often been referred to as a primary pathogen due to its high infection frequency among apparently immunocompetent patients. In order to scrutinize the immune status of patients and the lineages of etiologic agents, we analyzed patient histories and the molecular types of etiologic agents from 135 global C. gattii cases. Eighty-six of 135 patients had been diagnosed as immunocompetent, although some of them had underlying medical issues, and 49 were diagnosed as immunocompromised with risk factors similar to those seen in Cryptococcus neoformans infection. We focused on the 86 apparently immunocompetent patients and were able to obtain plasma from 32 (37%) to analyze for the presence of autoantibodies against the granulocyte-macrophage colonystimulating factor (GM-CSF) since these antibodies have been reported as a hidden risk factor for C. gattii infection. Among the 32 patients, 25 were free from any known other health issues, and 7 had various medical conditions at the time of diagnosis for cryptococcosis. Importantly, plasma from 19 (76%) of 25 patients with no recognized underlying medical condition showed the presence of GM-CSF autoantibodies, supporting this antibody as a major hidden risk factor for C. gattii infection. These data indicate that seemingly immunocompetent people with C. gattii infection warrant detailed evaluation for unrecognized immunologic risks. There was no relationship between molecular type and underlying conditions of patients. Frequency of each molecular type was related to its geographic origin exemplified by the overrepresentation of VGIV in HIV-positive (HIV1) patients due to its prevalence in Africa. IMPORTANCE The C. neoformans and C. gattii species complex causes cryptococcosis. The C. neoformans species complex is known as an opportunistic pathogen since it primarily infects immunocompromised patients. C. gattii species complex has been referred to as a primary pathogen due to its high infection frequency in apparently immunocompetent people. We analyzed 135 global cases of C. gattii infection with documented patient history. Eighty-six of 135 patients were originally diagnosed as immunocompetent and 49 as immunosuppressed with similar underlying conditions reported for C. neoformans infection. A significant number of C. gattii patients without known underlying conditions possessed autoantibodies against granulocytes-macrophage colony-stimulating factor (GM-CSF) in their plasma, supporting the presence of GM-CSF antibodies as a hidden risk factor for C. gattii infection. No relationship was found between C. gattii lineages and the underlying conditions except for overrepresentation of the molecular type VGIV among HIV1 patients due to the prevalence of VGIV in Africa. AU - Yang, Dong Hoon AU - England, Matthew R. AU - Salvator, Helene AU - Anjum, Seher AU - Park, Yoon Dong AU - Marr, Kieren A. AU - Chu, Laurie A. AU - Govender, Nelesh P. AU - Lockhart, Shawn R. AU - Desnos-Ollivier, Marie AU - Chen, Sharon AU - Halliday, Catriona AU - Kan, Alex AU - Chen, Jianghan AU - Wollenberg, Kurt R. AU - Zelazny, Adrian AU - Perfect, John R. AU - Chang, Yun C. AU - Bennett, John E. AU - Holland, Steven M. AU - Meyer, Wieland AU - Williamson, Peter R. AU - Kwon-Chung, Kyung J. DA - 2021/10// DO - 10.1128/MBIO.02708-21 IS - 5 KW - Africa / epidemiology KW - Autoantibodies / blood KW - Autoantibodies / immunology KW - Cryptococcosis / etiology* KW - Cryptococcosis / immunology KW - Cryptococcosis / microbiology KW - Cryptococcus gattii / classification KW - Cryptococcus gattii / genetics KW - Cryptococcus gattii / immunology KW - Cryptococcus gattii / pathogenicity* KW - Dong-Hoon Yang KW - HIV Infections / complications KW - HIV Infections / epidemiology KW - Humans KW - Immunocompetence KW - Immunocompromised Host KW - Intramural KW - Kyung J Kwon-Chung KW - MEDLINE KW - Matthew R England KW - N.I.H. KW - NCBI KW - NIH KW - NLM KW - National Center for Biotechnology Information KW - National Institutes of Health KW - National Library of Medicine KW - Opportunistic Infections / etiology* KW - Opportunistic Infections / immunology KW - Opportunistic Infections / microbiology* KW - PMC8546560 KW - PubMed Abstract KW - Research Support KW - Risk Factors KW - doi:10.1128/mBio.02708-21 KW - pmid:34700378 PB - mBio PY - 2021 TI - Cryptococcus gattii Species Complex as an Opportunistic Pathogen: Underlying Medical Conditions Associated with the Infection T2 - mBio UR - https://pubmed.ncbi.nlm.nih.gov/34700378/ VL - 12 ER - TY - JOUR AU - Monita, Monique M AU - Gonzalez, Lorena PY - 2021 SP - 1 EP - 5 TI - Mesenteric Ischemia , Acute Pathophysiology Toxicokinetics Treatment / Management T2 - Stat Pearls ER -