Studies in uveal physiology. II. Clinical studies of the anterior chamber clearance of isotopic tracers - O'Rourke, J; Macri, F J (Arch Ophthalmol, 1970)

Effect of topical betaxolol on acute rise of aqueous flare induced by prostaglandin E(2) in pigmented rabbits - Yanagisawa, S; Hayasaka, S; Zhang, X Y; Hayasaka, Y; Nagaki, Y; Kitagawa, K (Jpn J Ophthalmol, 2001)
PURPOSE: To evaluate the effects of topical betaxolol on experimental ocular inflammation. METHODS: Transcorneal diffusion of 25 microg/mL (7.09 x 10(-2) mmol/L) of prostaglandin E(2) (PGE(2)), placed in a glass cylinder, was employed to induce aqueous flare elevation in pigmented rabbits. Betaxolol was administered topically before PGE(2) application. Aqueous flare was measured with a laser flare cell meter. RESULTS: Four-, two-, and one-time topical instillations of betaxolol inhibited the PGE(2)-induced aqueous flare elevation by 44% +/- 8%, 32 +/- 7%, and 8 +/- 6%(mean +/- SD), respectively. The inhibition of flare elevation was dependent on the number of betaxolol instillations. CONCLUSION: Topical betaxolol has an inhibitory effect on PGE(2)-induced aqueous flare elevation in rabbit eyes.

The role of altered vascular permeability in recurrent uveitis - Limaye, S R; Rao, N A; Phillips, T M; Marak, G E (Int Ophthalmol, 1981)
Increasing ocular vascular permeability by topical application of prostaglandin E2 was found not to be a sufficient stimulus to induce the inflammation in either spontaneous immune disease in NZB or induced immune complex disease in rabbits.

A new implant for glaucoma. Effect of removing implants - Molteno, A C (Br J Ophthalmol, 1971)

Possible bilateral anterior uveitis secondary to metipranolol (OptiPranolol) therapy - KeBler, C (Arch Ophthalmol, 1994)

[ON LEPTOSPIRAL UVEITIS] - Tarkkanen, A; Raitta, C (Ophthalmologica, 1964)
Keywords: PHENYLEPHRINE; PREDNISOLONE, TOPICAL; UVEITIS; GERIATRICS; ATROPINE; ANTIBIOTICS; COMPLEMENT FIXATION TESTS; EPIDEMIOLOGY; FINLAND; HEMAGGLUTINATION; LATEX FIXATION TESTS; LEPTOSPIRA CANICOLA; LEPTOSPIRA ICTEROHAEMORRHAGIAE; LEPTOSPIROSIS; PREDNISOLONE, THERAPEUTIC

Anterior uveitis associated with fixed-combination latanoprost and timolol - Ornek, Kemal; Onaran, Zafer; Turgut, Yeliz (Can J Ophthalmol, 2008)

Bilateral granulomatous uveitis as a side effect of topical brimonidine: two case reports - Hondeghem, K; Augustinus, B; De Smet, M D (Bull Soc Belge Ophtalmol, 2009)

[Iontophoresis of calcium and adrenaline in treatment of inflammatory conditions of the eyes] - Mika, T; Szymankowa, G; Lisowski, Z; Merz, M (Klin Oczna, 1968)

[Comparative clinical-pharmacological studies on the effect and tolerance of "Pholedrin" and "Neosynephrine"] - Tost, M; Hammer, R (Dtsch Gesundheitsw, 1971)

Possible bilateral anterior uveitis secondary to metipranolol (optipranolol) therapy - Schultz, J S; Hoenig, J A; Charles, H (Arch Ophthalmol, 1993)

DANGERS OF STEROIDS IN OPHTHALMOLOGY WITH REPORT OF A CASE OF MYCOTIC PERFORATING CORNEAL ULCER - Warren, C M, Jr (J Med Assoc State Ala, 1964)
Keywords: ACETAZOLAMIDE; METHYLPREDNISOLONE; TOXICOLOGIC REPORT; UVEITIS; DEXAMETHASONE; BENDROFLUMETHIAZIDE; BETAMETHASONE; CORNEA; EYE INJURIES; MYCOSES; ULCER

Conservative management of the glaucomas - Phillips, C I (Trans Ophthalmol Soc U K, 1966)

[Diagnostic value of enzyme and hormone activity in the diagnosis and choice of treatment of eye diseases in children] - Faustov, V S; Kovalevskiĭ, E I; Kotiasheva, G I; Faustova, L A (Vestn Oftalmol, 1977)

Adult cytomegalic inclusion retinitis - Merritt, J C; Callender, C O (Ann Ophthalmol, 1978)
Two cases of adult cytomegalic inclusion retinitis are described in renal transplant patients. The areas of initial involvement by the retinitis were left atrophic and demarcated from normal retina by a hypopigmented area in the retina. Both cases were complicated by the development of a secondary glaucoma with open angles. The glaucoma in each patient was successfully managed by carbonic anhydrase inhibitors, epinephrine drops, and cycloplegias. One patient still retains normal visual acuity in the eye which had active retinitis.

Scleral buckling procedures. 8. Preoperative complications - Brockhurst, R J; Schepens, C L; Okamura, I D; Regan, C D; McMeel, J W (Arch Ophthalmol, 1965)

Oral prostaglandin E1 as a therapeutic modality for leg ulcers in Behçet's disease - Takeuchi, A; Hashimoto, T (Int J Clin Pharmacol Res, 1987)
Prostaglandin E1 (PGE1) has been generally given only by intravascular injection. Recently, an oral PGE1 named OP1206 has been developed. OP1206 is a potent inhibitor of platelet aggregation as well as a strong vasodilator, and its half-life in humans is extremely prolonged because it is not metabolized in the lungs. Leg ulceration is one of the cutaneous manifestations in Behçet's disease and sometimes is very difficult to treat. In this investigation five patients having Behçet's disease with leg ulcers were treated with OP1206. All of the patients had the leg ulcers for more than 2 months. Fifteen micrograms of OP1206 was given initially, and the dosage was increased to 30 micrograms whenever there were no adverse effects. All the patients were soon able to tolerate the drug and increased dosage. Within 2 weeks, regeneration of granulomatous tissues was observed in all cases. Furthermore, the leg ulcers healed within one year. Only one patient developed diarrhoea, but this symptom disappeared when he adjusted to the dosage. The findings strongly indicate that OP1206 is a safe and promising drug for the treatment of leg ulcers in Behçet's disease.

[Naphazoline therapy of iridocyclitis and episcleritis] - Von Nordheim, R W (Ned Tijdschr Geneeskd, 1954)
Keywords: IRIDOCYCLITIS/therapy; SYMPATHOMIMETICS/therapeutic use; SCLERA/diseases

UNILATERAL ACUTE RISE IN INTRAOCULAR PRESSURE FOLLOWING LONG-TERM BILATERAL LOCAL TREATMENT WITH PREDNISONE (ULTRACORTENOL) IN A CASE OF UVEITIS - Spiers, F (Acta Ophthalmol (Copenh), 1965)
Keywords: INTRAOCULAR PRESSURE; IRIDOCYCLITIS; DRUG THERAPY; TOXICOLOGIC REPORT; UVEITIS; PREDNISONE TOXICOLOGY; PREDNISONE, THERAPEUTIC

Aspiration of congenital and soft cataracts in foals and young horses - Gelatt, K N; Myers, V S, Jr; McClure, J R, Jr (J Am Vet Med Assoc, 1974)

[Diagnosis and therapy of Posner-Schlossman syndrome] - Hollwich, F (Ber Zusammenkunft Dtsch Ophthalmol Ges, 1978)

[Ophthalmological emergencies. 1. The acute red eye] - Gabler, B (MMW Fortschr Med, 2002)

[Age-specific characteristics of uveitis and the role of biogenic amines in their development] - Proshina, L Ia (Vestn Oftalmol, 1973)

Effect of propranolol and phenylbutazone on the prostaglandin like activity of the rabbit's iris in endotoxin induced iritis - el-Hawary, M B; el-Shiwy, T; Isaak, Z; Abdel-Wahed, S; Khayyal, M A (Bull Ophthalmol Soc Egypt, 1976)

[The treatment of posner-schlossmann's syndrome. (acute glaucomatocyclitic crises) (author's transl)] - Huismans, H (Klin Monbl Augenheilkd, 1975)
In the surgery two patients with Posner-Schlossmann-Syndrome were observed for several months. The therapy of the acute attack secondary glaucoma was the combination of Diamox, Cortison - and Neosynephrine eye-drops. With Pilocarpine the I.O.P. lowering was insufficient. In one case corneal precipitates typical for Heterochromia complicata Fuchs were observed.

Deposits in the superficial corneal stroma after combined topical corticosteroid and beta-blocking medication - Huige, W M; Beekhuis, W H; Rijneveld, W J; Schrage, N; Remeijer, L (Eur J Ophthalmol, 1991)

CME and anterior uveitis with latanoprost use - Camras, C B (Ophthalmology, 1998)

[Glaucoma related with photoreceptor outer segments in aqueous humor. Schwartz-Matsuo syndrome] - Gutiérrez, C; Merayo, J; Cuevas, J; Lázaro, M; Rebolleda, G; Muñoz-Negrete, F J (Arch Soc Esp Oftalmol, 2001)
CASE REPORT: We present the case of a patient who was initially diagnosed of hypertensive uveitis with marked fluctuation that was resistant to the common treatment. After a systematic examination, retinal detachment of the ora serrata in the inferotemporal quadrant was diagnosed. The sample of aqueous humor showed melanic pigment and degenerated photoreceptor outer segments. After retinal detachment surgery, the intraocular pressure returned to normal levels without antiglaucoma medication. DISCUSSION: The presence of photoreceptor outer segments in aqueous humor confirms the diagnosis of Schwartz-Matsuo syndrome, which should be considered as a differential diagnosis of iritis and glaucoma.

CME and anterior uveitis with latanoprost use - Eisenberg, D (Ophthalmology, 1998)

[Therapeutical difficulties in a patient with TB panuveitis and open angle glaucoma] - de Popa, Doina Pop; Smochină, Simona (Oftalmologia, 2002)
The article present the case of a young female patient showing TB panuveitis associated with primary glaucoma, as well as all the implications of the symptomatic and ethiological treatment of TB panuveitis on the increased intraocular pressions (IOP). There are also underlined the difficulties of maintaining the IOP between normal ranges under combined therapy for glaucoma.

Metipranolol associated granulomatous anterior uveitis: not so uncommon as thought - Burvenich, H (Bull Soc Belge Ophtalmol, 1995)
Two case reports of bilateral granulomatous anterior uveitis are described in patients with open angle glaucoma treated with metripranolol 0.6% eye drops. Several cases have been described in the United Kingdom and recently in the United States. In my opinion this reaction is not so uncommon as thought. Possible causes of this phenomenon are proposed keeping in mind that a hypotensive drug can cause intra ocular pressure rise. The incidence of similar cases seems to increase.

CLINICAL EVALUATION OF PROTOPAM - Byron, H M; Posner, I (Am J Ophthalmol, 1964)
Keywords: CATARACT EXTRACTION; PHENYLEPHRINE; TOXICOLOGIC REPORT; UVEITIS; CATARACT; GERIATRICS; EPINEPHRINE; ATROPINE; BELLADONNA; INFANT; OPHTHALMOLOGY; OXIMES; PARASYMPATHOMIMETICS; PHARMACOLOGY; PYRIDINES; SCOPOLAMINE

Studies on the mechanism of the breakdown of the blood-aqueous barrier in the rabbit eye - Bengtsson, E (Acta Ophthalmol Suppl, 1977)

[Secondary glaucoma, pathogenesis and clinic (author's transl)] - Merté, H J (Klin Monbl Augenheilkd, 1974)

[Glaucon and hypertensive iridocyclitis] - Anton, M; Kumstát, Z (Cesk Oftalmol, 1971)

Does timolol LA enhance the disrupting effect of travoprost on the blood-aqueous barrier? - Vishwanath, Mandagere R; Charles, Stephen J (Acta Ophthalmol Scand, 2006)

[EXPERIMENTAL STUDIES ON THE PROBLEM OF UVEITIS INDUCED BY STIMULATION OF THE EAR] - Meyerratken, E (Ber Zusammenkunft Dtsch Ophthalmol Ges, 1964)
Keywords: UVEITIS; PHARMACOLOGY; EAR; ERGOTAMINE; EXPERIMENTAL LAB STUDY; POLYVINYLPYRROLIDONE; RABBITS

A rationale for the treatment of symptoms in allergic diseases - Blue, J A (Ann Allergy, 1971)

The facility of aqueous outflow calculated from the rate of fall in applanation pressure after intravenous acetazolamide in man - Nissen, O I; Hoppe, R F (Acta Ophthalmol (Copenh), 1974)

[Significance of the use of adrenaline bitartrate associated with certain hypertensive iridocyclitis] - Amalric, P; Bessou, P; Farenc, M (Bull Soc Ophtalmol Fr, 1964)

[Studies on chorioretinitis induced in rabbits by stress (repeated administration of epinephrine)] - Miki, T; Sunada, I; Higaki, T (Nippon Ganka Gakkai Zasshi, 1972)

[Fluorescein angiographic findings in experimental retinopathy produced by intravenous adrenaline injection. Preliminary report] - Yoshioka, H; Sugita, T; Nagayoshi, K (Nihon Ganka Kiyo, 1970)

[Uveal reaction in an asthmatic patient treated by a local beta-blocker] - Agenos, B (Bull Soc Ophtalmol Fr, 1988)

[Two cases of temporary blindness after retrobulbar injection of novocaine-adrenalin carried out for the purpose of iridencleisis, occurring in hypertensive iridocyclitic patients] - Sedan, J (Bull Soc Ophtalmol Fr, 1959)
Keywords: IRIDOCYCLITIS/therapy; EPINEPHRINE/toxicology; PROCAINE/toxicology

[Effects of diamox on iridocyclitis] - Koyama, A; Sarai, K (Nihon Ganka Kiyo, 1962)
Keywords: ACETAZOLAMIDE; IRIDOCYCLITIS; FIBRIN

Oxygen uptake by canine uveal tissue: in vitro and in vivo methods compared - O'Rourke, J; Benson, C (Invest Ophthalmol, 1970)

Anterior uveitis in Papua New Guinea - Dethlefs, R (P N G Med J, 1981)

[Thermoelectrical studies in inflammatory eye diseases] - Matthaeus, W (Ber Zusammenkunft Dtsch Ophthalmol Ges, 1961)
Keywords: CONJUNCTIVITIS/physiology; EPINEPHRINE/pharmacology; EYE/pharmacology; IRITIS/physiology; KERATITIS/physiology; SYMPATHOLYTICS/pharmacology; TEMPERATURE

[Experimental naphazoline treatment of tuberculosis iridocyclitis] - Coster, J F; Von Nordheim, R W (Ned Tijdschr Geneeskd, 1957)
Keywords: SYMPATHOMIMETICS/effects; TUBERCULOSIS, OCULAR/experimental

Withdrawal of 0.6% Glauline (metipranolol) - Geraint, M (Br J Ophthalmol, 1991)

[Choroidal detachment after glaucoma surgery] - Sakai, T; Yamashita, S (Nihon Ganka Kiyo, 1968)

DEEP-CHAMBER GLAUCOMA AFTER CATARACT EXTRACTION - Gorin, G (Int Ophthalmol Clin, 1964)
Keywords: CATARACT EXTRACTION; GLAUCOMA; IRIDOCYCLITIS; POSTOPERATIVE COMPLICATIONS; DRUG THERAPY; PHENYLEPHRINE; TOXICOLOGIC REPORT; UVEITIS; STEROIDS; GERIATRICS; ANTERIOR CHAMBER; AQUEOUS HUMOR; CHILD; CYCLOPLEGICS; ECHOTHIOPHATE IODIDE; HEMORRHAGE

Clinical experience with propranolol in the treatment of glaucoma - Ohrström, A (Acta Ophthalmol (Copenh), 1973)

[Electron microscopic studies of epinephrine choroiditis in rabbits. 3. Scanning electron microscopic observations of the retinal pigment epithelial cells in the early stage (author's transl)] - Sunada, I; Mii, T; Inoue, K; Sato, T; Yasuzumi, T (Nippon Ganka Gakkai Zasshi, 1975)

Bilateral anterior uveitis associated with 0.3% minims metipranolol - Kamalarajah, S; Johnston, P B (Eye (Lond), 1999)

Stromal herpes, I.D.U. and steroids - DuToit, M M (Can J Ophthalmol, 1973)

[Sympathetic ophthalmia, sulfonamides and antibiotics] - Saubermann, G (Ophthalmologica, 1948)
Keywords: ANTIBIOTICS; EPINEPHRINE/toxicity; OPHTHALMIA/sympathetic; SULFONAMIDES

[Electronmicroscopic studies of epinephrine choroiditis in rabbits. I. Pigment epithelium and Bruch's membrane in the healed stage (author's transl)] - Yasuzumi, T; Miki, T; Sugimoto, K (Nippon Ganka Gakkai Zasshi, 1974)

[Studies on experimental central serous chorioretinopathy. Fluorescein angiographic findings (author's transl)] - Yoshioka, H; Katsume, Y; Akune, H; Ishibashi, R; Nagasaki, H (Nippon Ganka Gakkai Zasshi, 1981)

[Experimental study of choroidoretinopathy by intravenous injection of adrenaline] - Nagayoshi, K (Nippon Ganka Gakkai Zasshi, 1971)

Intra-ocular medication with special reference to depomedrone - Phillpotts, J S (Trans Ophthalmol Soc U K, 1969)

[Changes in intraocular tension of inflammatory origin] - Weekers, R (Arch Ophtalmol Rev Gen Ophtalmol, 1973)

MANAGEMENT OF HERPES ZOSTER OPHTHALMICUS. A CLINICAL STUDY OF 78 CASES - Jain, B S; Nath, J; Srivastava, K N (J Indian Med Assoc, 1964)
Keywords: IRIDOCYCLITIS; TOXICOLOGIC REPORT; ADOLESCENCE; GERIATRICS; ATROPINE; CORNEA; BELLADONNA; ERGOTAMINE; CHILD; CHICKENPOX; HERPES ZOSTER, OCULAR; HYDROCORTISONE, TOPICAL; INDIA; NEURALGIA; OXYTETRACYCLINE; PENICILLIN; PHYSIOLOGY; TETRACYCLINE

[Biochemical shifts in experimental uveitis as a guideline for clinical studies] - Kovalevskiĭ, E I; Kuznetsova, T P; Proshina, L Ia (Vestn Oftalmol, 1975)

[Platelet function in patients with Behçet's disease--a study on platelet aggregability] - Ohsone, T; Yoshikawa, K; Kogure, M (Nippon Ganka Gakkai Zasshi, 1988)

[Iritis with synechia incorrectly treated] (Lakartidningen, 1976)

[A CASE OF BLENNORRHAGIC IRIDOCYCLITIS IN A SCHIZOPHRENIC] - Zlatar, P (Ophthalmologica, 1964)
Keywords: IRIDOCYCLITIS; DRUG THERAPY; EPINEPHRINE; ATROPINE; PENICILLIN; ARTHRITIS; COCAINE; GONORRHEA; SCHIZOPHRENIA; URETHRITIS

Liberation of iris pigment in the anterior chamber - Aggarwal, J L; Beveridge, B (Br J Ophthalmol, 1971)

Anatomy and physiology of the cornea - DelMonte, Derek W.; Kim, Terry (Journal of Cataract and Refractive Surgery, 2011)

Comparison of corneal endothelial cell analysis in patients with uveitis and healthy subjects - Guclu, Hande; Gurlu, Vuslat (International Ophthalmology, 2019)

Comparison of corneal endothelial cell analysis in patients with uveitis and healthy subjects - Guclu, Hande; Gurlu, Vuslat (International Ophthalmology, 2019)

Corneal Endothelium in Patients with Anterior Uveitis - Alfawaz, Abdullah M.; Holland, Gary N.; Yu, Fei; Margolis, Mathew S.; Giaconi, JoAnn A.; Aldave, Anthony J. (Ophthalmology, 2016)

Corneal Endothelium in Patients with Anterior Uveitis - Alfawaz, Abdullah M.; Holland, Gary N.; Yu, Fei; Margolis, Mathew S.; Giaconi, JoAnn A.; Aldave, Anthony J. (Ophthalmology, 2016)

Potential Factors of Corneal Endothelial Cells for Progression in Children with Uveitis - Chen, Xu; Shao, Yi; Wu, Shi-Nan; Zhou, Shan-Bi (Disease Markers, 2021)
Objective. To observe the morphological changes and abnormal structure of corneal endothelial cells in children with uveitis, to analyze the related factors affecting the morphological changes of corneal endothelial cells, and to explore the clinical application of a corneal endothelial microscope in children with uveitis. Methods. The corneal endothelial cells of 70 patients with uveitis were photographed with the Topcon SP-3000 noncontact corneal endothelial microscope, and the corneal endothelial cell density (CD), average cell area (AVE), coefficient of variation of the cell area (CV), and percentage of hexagonal cells (PHC) were measured with the IMAGEnet system. Twenty-eight patients (56 eyes) with monocular uveitis were selected, with the affected eyes (28 eyes) as the experimental group and the contralateral healthy eyes (28 eyes) as the control group. The corneal endothelial cell parameters between the two groups were statistically analyzed. The parameters of corneal endothelial cells in 70 children with uveitis were compared, and the effects of the course of the disease, inflammatory cells in the anterior chamber, and posterior corneal deposition (KP) on the parameters of corneal endothelial cells were analyzed. Results. There are four abnormal forms of the corneal endothelium in children with uveitis: enlarged cell area gap, irregular cell shape, blurred intercellular space, and cell loss. KP showed irregular high reflective white spots in the corneal endothelial microscope images, surrounded by dark areas, and existed in all the eyes with dusty KP found in slit lamp examination and a small number of eyes without obvious KP. Comparing the corneal endothelial cell parameters between the experimental group and the control group, it was found that the corneal endothelial CD and PHC of the former were lower than those of the latter, and the difference was statistically significant ( P < 0.001 and P = 0.018 , respectively). The AVE and CA of the former were higher than those of the latter ( P = 0.013 and P = 0.046 , respectively). The corneal endothelial cell density of the eyes with a course of the disease of more than 1 year was lower than that of the eyes with a course of the disease less than 1 year, the coefficient of variation of the corneal endothelial cell area of the eyes with KP was higher than that of the eyes without KP, and the difference was statistically significant ( P = 0.003 and P = 0.030 , respectively). Conclusion. Corneal endothelial microscopy is one of the important methods for the detection of uveitis with high sensitivity. The change of morphological parameters of corneal endothelial cells is one of the important indexes to assist in the diagnosis of uveitis and can be further promoted in ophthalmological examination.

Health-related quality of life in patients with uveitis - Shamdas, Mohith; Bassilious, Kerolos; Murray, Philip Ian (British Journal of Ophthalmology, 2019)
Background/aims To measure health-related quality of life (HRQOL) in patients with uveitis using time trade-off (TTO) and standard gamble (SG) methods of direct utility analysis. Methods Consecutive patients attending a tertiary referral uveitis clinic were administered standardised, interview-delivered TTO and SG questionnaires and completed the European Quality of Life Five Dimensions Five Level (EQ5D-5L) questionnaire. Clinical data recorded included best-corrected visual acuity, uveitis anatomical and clinical classifications, duration since diagnosis, disease activity, current medication and any ocular or systemic comorbidities. Results Two hundred patients with uveitis (124 female, 76 male, median age 54 years) were included. Overall mean TTO utility was 0.831 (95% CI 0.802 to 0.860); mean SG utility was 0.868 (95% CI 0.840 to 0.896) and mean EQ5D-5L utility was 0.742 (95% CI 0.702 to 0.782). There was a negative correlation between visual acuity and mean HRQOL (6/12 or better: TTO 0.86, SG 0.893; 6/15–6/60: TTO 0.662, SG 0.742; worse than 6/60: TTO 0.608, SG 0.712). Poor vision in the better- seeing eye (p=0.004), bilateral disease (p=0.047) and concurrent glaucomatous optic neuropathy (p=0.005) were predictors of poor TTO HRQOL. No correlation was found between HRQOL and duration of diagnosis, a flare of uveitis or being on systemic therapy. Patients with uveitis with poor vision have a TTO value worse than patients with end-stage renal failure on haemodialysis or those with AIDS. Conclusion Loss of vision resulting from uveitis is associated with reduced HRQOL. The TTO and SG utility values appear directly dependent on the degree of vision loss and not on the duration of disease or systemic medications.

A Focus on the Epidemiology of Uveitis - Tsirouki, Theodora; Dastiridou, Anna; Symeonidis, Chrysanthos; Tounakaki, Ourania; Brazitikou, Irini; Kalogeropoulos, Christos; Androudi, Sofia (Ocular Immunology and Inflammation, 2018)

Understanding uveitis: The impact of research on visual outcomes - de Smet, Marc D.; Taylor, Simon R.J.; Bodaghi, Bahram; Miserocchi, Elisabetta; Murray, Philip I.; Pleyer, Uwe; Zierhut, Manfred; Barisani-Asenbauer, Talin; LeHoang, Phuc; Lightman, Sue (Progress in Retinal and Eye Research, 2011)

Prevalence of Noninfectious Uveitis in the United States: A Claims-Based Analysis - Thorne, Jennifer E.; Suhler, Eric; Skup, Martha; Tari, Samir; Macaulay, Dendy; Chao, Jingdong; Ganguli, Arijit (JAMA Ophthalmology, 2016)

Optical coherence tomography and optical coherence tomography angiography in uveitis: A review - Invernizzi, Alessandro; Cozzi, Mariano; Staurenghi, Giovanni (Clinical & Experimental Ophthalmology, 2019)

Comparison of corneal endothelial cell analysis in patients with uveitis and healthy subjects - Guclu, Hande; Gurlu, Vuslat (International Ophthalmology, 2019)

The human corneal endothelium: New insights into electrophysiology and ion channels - Mergler, Stefan; Pleyer, Uwe (Progress in Retinal and Eye Research, 2007)

The human corneal endothelium: New insights into electrophysiology and ion channels - Mergler, Stefan; Pleyer, Uwe (Progress in Retinal and Eye Research, 2007)

Regulation of corneal endothelial barrier function by adenosine, cyclic AMP, and protein kinases - Riley, M. V.; Winkler, B. S.; Starnes, C. A.; Peters, M. I.; Dang, L. (Investigative Ophthalmology & Visual Science, 1998)
PURPOSE: To determine which processes or factors that regulate corneal hydration are responsible for the hydration-modulating effects of adenosine. Influx of fluid to the stroma and efflux to the aqueous humor are governed, respectively, by the imbibition pressure of the stromal matrix and the transendothelial ionic gradients determined by the permeability and active transport characteristics of this monolayer. The focus of this study was to assess the effects of adenosine on these endothelial parameters. METHODS: Isolated corneas freshly dissected from rabbit eyes were used throughout. Active ion transport was assessed by measurement of 86Rb+ uptake by the endothelial cells of intact corneas incubated for 30 minutes in 25 mM HCO3(-)-Ringer with agents promoting corneal deturgescence or corneal swelling. Intracellular and extracellular fluid in the scraped endothelial cell mass was estimated from simultaneous counts of 3H-mannitol and 14C-urea, allowing calculation of tissue-to-medium (T-M) ratios of 86Rb+ in cell water. Permeability of the endothelium was determined by measuring the efflux into the superfusate of 5-carboxyfluorescein (CF) applied to the stroma of deepithelialized corneas superfused at the endothelial surface with the same media described for 86Rb+ uptake. Thickness of these corneas and of others fixed for scanning electron microscopy was monitored with a specular microscope. RESULTS: In the control medium, 25 mM HCO3(-)-Ringer, 86Rb+ was accumulated to yield a T-M ratio of 6.21. Neither adenosine nor other agents that increase cyclic adenosine monophosphate (cAMP)--that is, forskolin and dibutyryl cAMP--changed this value to a significant extent. Bumetanide had no effect, but ouabain caused a decrease in T-M to 1.30, a 79% inhibition. Elimination of Na+ or HCO3- also caused marked decreases in uptake. Permeability to CF in control medium was 3.40 x 10(-4) cm/min. A decrease of more than 20% (P < 0.05) was seen in the presence of adenosine and cAMP promoters and also with the protein kinase inhibitor H-8, whereas phorbol myristate acetate caused an increase to 4.50 x 10(-4) cm/min (P < 0.01). Ouabain caused no change, but blocked the effects of adenosine. Reducing the Ca2+ concentration of the superfusing medium caused time-dependent increases in permeability to 4.57 at 15 to 45 minutes and 12.5 at 80 to 110 minutes. At the earlier time, this increase in permeability could be prevented by the addition of adenosine or H-8. Elimination of Na+ or HCO3- ions from the medium caused a small decrease in permeability and, like ouabain, blocked the effect of adenosine. Changes in thickness of corneas were consistent, in most cases, with the observed alterations in 86Rb+ uptake or permeability to CF. Scanning electron microscopy showed contraction and rounding of endothelial cells in low Ca2+ medium, with stretching of intercellular borders, features that were largely eliminated when adenosine was also present. CONCLUSIONS: Adenosine, through increasing cAMP, decreases permeability of the corneal endothelium. This effect, rather than a change in the active transport (fluid pump) mechanism, is responsible for the promotion of deturgescence and maintenance of lower steady state thickness of corneas exposed to adenosine. The mechanism may involve the phosphorylation state of cytoskeletal proteins and seems to be dependent on an undisturbed environment of monovalent ions.
Keywords: Animals; Permeability; Rabbits; Adenosine; Biological Transport, Active; Body Water; Calcium; Cyclic AMP; Endothelium, Corneal; Enzyme Inhibitors; Fluoresceins; Ion Transport; Isoquinolines; Microscopy, Electron, Scanning; Ouabain; Protein Kinase Inhibitors; Protein Kinases; Rubidium Radioisotopes; Sodium

Clinical specular microscopy - Sugar, Alan (Survey of Ophthalmology, 1979)

Changes in the normal corneal endothelial cellular pattern as a function of age - Yee, Richard W.; Matsuda, Mamoru; Schultz, Richard O.; Edelhauser, Henry F. (Current Eye Research, 1985)

Changes in the normal corneal endothelial cellular pattern as a function of age - Yee, Richard W.; Matsuda, Mamoru; Schultz, Richard O.; Edelhauser, Henry F. (Current Eye Research, 1985)

Endothelial Cell Density to Predict Endothelial Graft Failure After Penetrating Keratoplasty - Lass, Jonathan H. (Archives of Ophthalmology, 2010)

Donor Age and Corneal Endothelial Cell Loss 5 Years after Successful Corneal Transplantation (Ophthalmology, 2008)

Donor Age and Factors Related to Endothelial Cell Loss 10 Years after Penetrating Keratoplasty - Lass, Jonathan H.; Benetz, Beth Ann; Gal, Robin L.; Kollman, Craig; Raghinaru, Dan; Dontchev, Mariya; Mannis, Mark J.; Holland, Edward J.; Chow, Christopher; McCoy, Kristen; Price, Francis W.; Sugar, Alan; et al. (Ophthalmology, 2013)

Changes in the normal corneal endothelial cellular pattern as a function of age - Yee, Richard W.; Matsuda, Mamoru; Schultz, Richard O.; Edelhauser, Henry F. (Current Eye Research, 1985)

Corneal Decompensation in Uveitis Patients: Incidence, Etiology, and Outcome - Wong, Shiao W.; Carley, Fiona; Jones, Nicholas P. (Ocular Immunology and Inflammation, 2021)

Corneal Decompensation in Uveitis Patients: Incidence, Etiology, and Outcome - Wong, Shiao W.; Carley, Fiona; Jones, Nicholas P. (Ocular Immunology and Inflammation, 2021)

The PRISMA 2020 statement: an updated guideline for reporting systematic reviews - Page, Matthew J; McKenzie, Joanne E; Bossuyt, Patrick M; Boutron, Isabelle; Hoffmann, Tammy C; Mulrow, Cynthia D; Shamseer, Larissa; Tetzlaff, Jennifer M; Akl, Elie A; Brennan, Sue E; Chou, Roger; Glanville, Julie; et al. (BMJ, 2021)

Assessment of publication bias and outcome reporting bias in systematic reviews of health services and delivery research: A meta-epidemiological study - Ayorinde, Abimbola A.; Williams, Iestyn; Mannion, Russell; Song, Fujian; Skrybant, Magdalena; Lilford, Richard J.; Chen, Yen-Fu (PLOS ONE, 2020)

The Standardization of Uveitis Nomenclature (SUN) Project: Development of a Clinical Evidence Base Utilizing Informatics Tools and Techniques - Trusko, B.; Thorne, J.; Jabs, D.; Belfort, R.; Dick, A.; Gangaputra, S.; Nussenblatt, R.; Okada, A.; Rosenbaum, J.; for The Standardization of Uveitis Nomenclature (SUN) Project (Methods of Information in Medicine, 2013)
Summary Background: Given the recent increased focus on evidence-based medicine, it is critical that diseases and syndromes have accurate and complete descriptions, including standardized and widely accepted terminologies. Standardizing these descriptions and terminologies is necessary to develop tools such as computerized data entry forms and classification criteria. This need is especially true for diseases that are relatively uncommon, such as uveitis. Objectives: To develop a standardized and internationally accepted terminology for the field of uveitis. Methods: The Standardization of Uveitis Nomenclature (SUN) Working Group (WG) is an international group of 79 uveitis experts from 18 countries and 62 clinical centers. Initial terminology was developed utilizing a “modified” green field approach, which was enhanced through web-based surveys and teleconferences via a “modified” Delphi technique. Terms were mapped provisionally into ontologic dimensions for each syndrome. The Working Group then met and utilized nominal group techniques as a formalized method of finalizing the mappings. Results: Mapping of terms into dimensions to describe 28 major uveitic diseases was confirmed using nominal group techniques (achieving super-majority consensus) for each of the diseases at a meeting of the entire WG. Conclusions: The SUN WG utilized an informatics-based approach to develop a stand ardized and internationally accepted terminology for the uveitides.

Ocular complications of pediatric uveitis - Rosenberg, Krista D.; Feuer, William J.; Davis, Janet L. (Ophthalmology, 2004)

Vision loss in anterior uveitis - Al-Ani, Haya H; Sims, Joanne L; Tomkins-Netzer, Oren; Lightman, Susan; Niederer, Rachael L (British Journal of Ophthalmology, 2020)
Aims To evaluate the long-term risk of permanent vision loss in subjects with anterior uveitis. Methods Retrospective study of subjects attending uveitis clinic at Auckland District Health Board and Moorfields Eye Hospital between 2008 and 2018. Main outcome measures were: best corrected visual acuity (BCVA); moderate vision loss (MVL ≤20/50); and severe vision loss (SVL ≤20/200). Results 2526 eyes of 1814 subjects were included with a mean follow-up of 6.8 years (17 235.4 eye-years of follow-up). MVL occurred in 240 eyes (9.5%) during the follow-up period, of which 97 (3.8%) had permanent MVL due to uveitis. The incidence of permanent MVL due to uveitis was 0.006 per eye-year with a cumulative risk at 10 years of 6.6% (5.2%–8.4%). The most common cause of permanent MVL due to uveitis was uveitic glaucoma (31.3%), followed by cystoid macular oedema (27.1%) and corneal scar (21.9%). SVL occurred in 80 eyes (3.2%) during the follow-up period, of which 39 (1.5%) had permanent SVL due to uveitis. The incidence of permanent SVL due to uveitis was 0.002 per eye-year with a cumulative risk at 10 years of 2.6% (1.8%–3.7%). Multivariate analysis showed older age at presentation, chronic anterior uveitis (CAU), infectious aetiology and poor presenting BCVA were all risk factors for permanent MVL due to uveitis. Conclusions Although vision loss is an uncommon complication in anterior uveitis, the risk is greatest in those with CAU, infectious aetiology and poor presenting BCVA. Uveitic glaucoma is the most common cause of vision loss.

Optical coherence tomography and optical coherence tomography angiography in uveitis: A review - Invernizzi, Alessandro; Cozzi, Mariano; Staurenghi, Giovanni (Clinical & Experimental Ophthalmology, 2019)

Comparison of corneal endothelial cell analysis in patients with uveitis and healthy subjects - Guclu, Hande; Gurlu, Vuslat (International Ophthalmology, 2019)

Foodborne streptococcal tonsillopharyngitis outbreak in a hospital - Karabela, Şemsi Nur; Şenoğlu, Sevtap; Altuntaş Aydin, Özlem; Baydili, Kürşad Nuri; Aksu, Özlem; Kart Yaşar, Kadriye (Central European Journal of Public Health, 2022)

Intraocular Inflammation - Zierhut, Manfred; Pavesio, Carlos; Ohno, Shigeaki; Orefice, Fernando; Rao, Narsing A. (Springer Berlin Heidelberg, 2016)

Corneal Endothelium in Patients with Anterior Uveitis - Alfawaz, Abdullah M.; Holland, Gary N.; Yu, Fei; Margolis, Mathew S.; Giaconi, JoAnn A.; Aldave, Anthony J. (Ophthalmology, 2016)

Intraocular Inflammation - Zierhut, Manfred; Pavesio, Carlos; Ohno, Shigeaki; Orefice, Fernando; Rao, Narsing A. (Springer Berlin Heidelberg, 2016)

Review on the Worldwide Epidemiology of Uveitis - Miserocchi, Elisabetta; Fogliato, Giovanni; Modorati, Giulio; Bandello, Francesco (European Journal of Ophthalmology, 2013)

Quality of life in patients with uveitis: data from the ULISSE study (Uveitis: cLInical and medico-economic evaluation of a Standardised Strategy for the Etiological diagnosis) - Bertrand, Pierre-jean; Jamilloux, Yvan; Kodjikian, Laurent; Errera, Marie-Helene; Perard, Laurent; Pugnet, Gregory; Tieulie, Nathalie; Andre, Marc; Bielefeld, Philip; Bron, Alain M; Decullier, Evelyne; Bin, Sylvie; et al. (British Journal of Ophthalmology, 2021)
Aims To assess vision-related (VR-QOL) and health-related quality of life (HR-QOL) in a large series of patients with de novo uveitis at baseline and 6-month follow-up. Methods Non-inferiority, prospective, multicentre, cluster randomised controlled trial registered under the Unique Identifier: NCT01162070 . VR-QOL and HR-QOL were assessed by the 25-item National Eye Institute Visual Function Questionnaire (VFQ-25) and the Medical Outcomes Study 36-item Short Form Survey (SF-36). Results At inclusion, 466 patients completed the VFQ-25. The mean composite score was 80.0 (±16.7). In multivariate analysis, higher age, female sex and insidious onset were significantly associated with lower QOL. At 6 months, 138 patients completed the VFQ-25, with a significantly higher mean composite score of 82.6 (±16.7). SF-36 mental component was 42.9 (±11.3) and physical component was 47.2 (±8.5) at inclusion (n=425). HR-QOL improvement at 6 months was not clinically significant. Conclusion QOL seems relatively well preserved in this cohort; only VR-QOL improved significantly at 6 months, especially in patients with low initial visual acuity.

Corneal Endothelium in Patients with Anterior Uveitis - Alfawaz, Abdullah M.; Holland, Gary N.; Yu, Fei; Margolis, Mathew S.; Giaconi, JoAnn A.; Aldave, Anthony J. (Ophthalmology, 2016)

Potential Factors of Corneal Endothelial Cells for Progression in Children with Uveitis - Chen, Xu; Shao, Yi; Wu, Shi-Nan; Zhou, Shan-Bi (Disease Markers, 2021)
Objective. To observe the morphological changes and abnormal structure of corneal endothelial cells in children with uveitis, to analyze the related factors affecting the morphological changes of corneal endothelial cells, and to explore the clinical application of a corneal endothelial microscope in children with uveitis. Methods. The corneal endothelial cells of 70 patients with uveitis were photographed with the Topcon SP-3000 noncontact corneal endothelial microscope, and the corneal endothelial cell density (CD), average cell area (AVE), coefficient of variation of the cell area (CV), and percentage of hexagonal cells (PHC) were measured with the IMAGEnet system. Twenty-eight patients (56 eyes) with monocular uveitis were selected, with the affected eyes (28 eyes) as the experimental group and the contralateral healthy eyes (28 eyes) as the control group. The corneal endothelial cell parameters between the two groups were statistically analyzed. The parameters of corneal endothelial cells in 70 children with uveitis were compared, and the effects of the course of the disease, inflammatory cells in the anterior chamber, and posterior corneal deposition (KP) on the parameters of corneal endothelial cells were analyzed. Results. There are four abnormal forms of the corneal endothelium in children with uveitis: enlarged cell area gap, irregular cell shape, blurred intercellular space, and cell loss. KP showed irregular high reflective white spots in the corneal endothelial microscope images, surrounded by dark areas, and existed in all the eyes with dusty KP found in slit lamp examination and a small number of eyes without obvious KP. Comparing the corneal endothelial cell parameters between the experimental group and the control group, it was found that the corneal endothelial CD and PHC of the former were lower than those of the latter, and the difference was statistically significant ( P < 0.001 and P = 0.018 , respectively). The AVE and CA of the former were higher than those of the latter ( P = 0.013 and P = 0.046 , respectively). The corneal endothelial cell density of the eyes with a course of the disease of more than 1 year was lower than that of the eyes with a course of the disease less than 1 year, the coefficient of variation of the corneal endothelial cell area of the eyes with KP was higher than that of the eyes without KP, and the difference was statistically significant ( P = 0.003 and P = 0.030 , respectively). Conclusion. Corneal endothelial microscopy is one of the important methods for the detection of uveitis with high sensitivity. The change of morphological parameters of corneal endothelial cells is one of the important indexes to assist in the diagnosis of uveitis and can be further promoted in ophthalmological examination.

Intraocular Inflammation - Zierhut, Manfred; Pavesio, Carlos; Ohno, Shigeaki; Orefice, Fernando; Rao, Narsing A. (Springer Berlin Heidelberg, 2016)

Prevalence and Incidence of Uveitis: A Systematic Review and Meta-analysis - García-Aparicio, Ángel; García De Yébenes, M. Jesús; Otón, Teresa; Muñoz-Fernández, Santiago (Ophthalmic Epidemiology, 2021)

Standardization of Uveitis Nomenclature for Reporting Clinical Data. Results of the First International Workshop (American Journal of Ophthalmology, 2005)

Intraocular Inflammation - Zierhut, Manfred; Pavesio, Carlos; Ohno, Shigeaki; Orefice, Fernando; Rao, Narsing A. (Springer Berlin Heidelberg, 2016)

Standardization of Uveitis Nomenclature for Reporting Clinical Data. Results of the First International Workshop (American Journal of Ophthalmology, 2005)

Intraocular Inflammation - Zierhut, Manfred; Pavesio, Carlos; Ohno, Shigeaki; Orefice, Fernando; Rao, Narsing A. (Springer Berlin Heidelberg, 2016)

Standardization of Uveitis Nomenclature for Reporting Clinical Data. Results of the First International Workshop (American Journal of Ophthalmology, 2005)

Intraocular Inflammation - Zierhut, Manfred; Pavesio, Carlos; Ohno, Shigeaki; Orefice, Fernando; Rao, Narsing A. (Springer Berlin Heidelberg, 2016)

Vision Loss in Uveitis - E.Cunningham, Emmett T.; Zierhut, Manfred (Ocular Immunology and Inflammation, 2021)

Understanding uveitis: The impact of research on visual outcomes - De Smet, Marc D.; Taylor, Simon R.J.; Bodaghi, Bahram; Miserocchi, Elisabetta; Murray, Philip I.; Pleyer, Uwe; Zierhut, Manfred; Barisani-Asenbauer, Talin; LeHoang, Phuc; Lightman, Sue (Progress in Retinal and Eye Research, 2011)

Ethnic and Mouse Strain Differences in Central Corneal Thickness and Association with Pigmentation Phenotype - Dimasi, David P.; Hewitt, Alex W.; Kagame, Kenneth; Ruvama, Sam; Tindyebwa, Ludovica; Llamas, Bastien; Kirk, Kirsty A.; Mitchell, Paul; Burdon, Kathryn P.; Craig, Jamie E. (PLoS ONE, 2011)

Intraocular Pressure, Central Corneal Thickness, and Prevalence of Open-Angle Glaucoma: The Los Angeles Latino Eye Study - Francis, Brian A.; Varma, Rohit; Chopra, Vikas; Lai, Mei-Ying; Shtir, Corina; Azen, Stanley P. (American Journal of Ophthalmology, 2008)

Ocular Hypertension Treatment Study (OHTS) commentary: - Lee, Brian L.; Wilson, M. Roy (Current Opinion in Ophthalmology, 2003)

Uveitic glaucoma - Anesi, Stephen; Metzinger, Jamie Lynne; Cerón, Olga; Foster, C. Stephen (Eye and vision research developments, 2016)
Keywords: Glaucoma; Uveitis

Comparison of corneal endothelial cell analysis in patients with uveitis and healthy subjects - Guclu, Hande; Gurlu, Vuslat (International Ophthalmology, 2019)

Comparison of corneal endothelial cell analysis in patients with uveitis and healthy subjects - Guclu, Hande; Gurlu, Vuslat (International Ophthalmology, 2019)

Changes in Corneal Thickness and Specular Microscopic Indices in Acute Unilateral Anterior Uveitis - Banaee, Tooka; Shafiee, Masoud; Alizadeh, Reza; Naseri, Mohamad Hashem (Ocular Immunology and Inflammation, 2016)

Declaración PRISMA 2020: una guía actualizada para la publicación de revisiones sistemáticas - Page, Matthew J.; McKenzie, Joanne E.; Bossuyt, Patrick M.; Boutron, Isabelle; Hoffmann, Tammy C.; Mulrow, Cynthia D.; Shamseer, Larissa; Tetzlaff, Jennifer M.; Akl, Elie A.; Brennan, Sue E.; Chou, Roger; Glanville, Julie; et al. (Revista Española de Cardiología, 2021)

Methodological quality and synthesis of case series and case reports - Murad, Mohammad Hassan; Sultan, Shahnaz; Haffar, Samir; Bazerbachi, Fateh (BMJ Evidence-Based Medicine, 2018)
Case reports and case series are uncontrolled study designs known for increased risk of bias but have profoundly influenced the medical literature and continue to advance our knowledge. In this guide, we present a framework for appraisal, synthesis and application of evidence derived from case reports and case series. We propose a tool to evaluate the methodological quality of case reports and case series based on the domains of selection, ascertainment, causality and reporting and provide signalling questions to aid evidence-based practitioners and systematic reviewers in their assessment. We suggest using evidence derived from case reports and case series to inform decision-making when no other higher level of evidence is available.

Assessing risk of bias in prevalence studies: modification of an existing tool and evidence of interrater agreement - Hoy, Damian; Brooks, Peter; Woolf, Anthony; Blyth, Fiona; March, Lyn; Bain, Chris; Baker, Peter; Smith, Emma; Buchbinder, Rachelle (Journal of Clinical Epidemiology, 2012)

Assessment of publication bias and outcome reporting bias in systematic reviews of health services and delivery research: A meta-epidemiological study - Ayorinde, Abimbola A.; Williams, Iestyn; Mannion, Russell; Song, Fujian; Skrybant, Magdalena; Lilford, Richard J.; Chen, Yen-Fu (PLOS ONE, 2020)

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Methodological quality and synthesis of case series and case reports - Murad, Mohammad Hassan; Sultan, Shahnaz; Haffar, Samir; Bazerbachi, Fateh (BMJ Evidence-Based Medicine, 2018)
Case reports and case series are uncontrolled study designs known for increased risk of bias but have profoundly influenced the medical literature and continue to advance our knowledge. In this guide, we present a framework for appraisal, synthesis and application of evidence derived from case reports and case series. We propose a tool to evaluate the methodological quality of case reports and case series based on the domains of selection, ascertainment, causality and reporting and provide signalling questions to aid evidence-based practitioners and systematic reviewers in their assessment. We suggest using evidence derived from case reports and case series to inform decision-making when no other higher level of evidence is available.

Assessing risk of bias in prevalence studies: modification of an existing tool and evidence of interrater agreement - Hoy, Damian; Brooks, Peter; Woolf, Anthony; Blyth, Fiona; March, Lyn; Bain, Chris; Baker, Peter; Smith, Emma; Buchbinder, Rachelle (Journal of Clinical Epidemiology, 2012)

Changes in the normal corneal endothelial cellular pattern as a function of age - Yee, Richard W.; Matsuda, Mamoru; Schultz, Richard O.; Edelhauser, Henry F. (Current Eye Research, 1985)

Résultats de la microscopie spéculaire au cours des uvéites actives - Zina, S.; Khochtali, S.; Sayadi, S.; Ksiaa, I.; Abroug, N.; Khairallah, M. (Journal Français d'Ophtalmologie, 2021)

Corneal endothelium in unilateral Fuchs heterochromic iridocyclitis - Sravani, NGeetha; Mohamed, Ashik; Chaurasia, Sunita; Durgam, ShravyaSri; Murthy, SomasheilaI (Indian Journal of Ophthalmology, 2020)

Potential Factors of Corneal Endothelial Cells for Progression in Children with Uveitis - Chen, Xu; Shao, Yi; Wu, Shi-Nan; Zhou, Shan-Bi (Disease Markers, 2021)
Objective. To observe the morphological changes and abnormal structure of corneal endothelial cells in children with uveitis, to analyze the related factors affecting the morphological changes of corneal endothelial cells, and to explore the clinical application of a corneal endothelial microscope in children with uveitis. Methods. The corneal endothelial cells of 70 patients with uveitis were photographed with the Topcon SP-3000 noncontact corneal endothelial microscope, and the corneal endothelial cell density (CD), average cell area (AVE), coefficient of variation of the cell area (CV), and percentage of hexagonal cells (PHC) were measured with the IMAGEnet system. Twenty-eight patients (56 eyes) with monocular uveitis were selected, with the affected eyes (28 eyes) as the experimental group and the contralateral healthy eyes (28 eyes) as the control group. The corneal endothelial cell parameters between the two groups were statistically analyzed. The parameters of corneal endothelial cells in 70 children with uveitis were compared, and the effects of the course of the disease, inflammatory cells in the anterior chamber, and posterior corneal deposition (KP) on the parameters of corneal endothelial cells were analyzed. Results. There are four abnormal forms of the corneal endothelium in children with uveitis: enlarged cell area gap, irregular cell shape, blurred intercellular space, and cell loss. KP showed irregular high reflective white spots in the corneal endothelial microscope images, surrounded by dark areas, and existed in all the eyes with dusty KP found in slit lamp examination and a small number of eyes without obvious KP. Comparing the corneal endothelial cell parameters between the experimental group and the control group, it was found that the corneal endothelial CD and PHC of the former were lower than those of the latter, and the difference was statistically significant ( P < 0.001 and P = 0.018 , respectively). The AVE and CA of the former were higher than those of the latter ( P = 0.013 and P = 0.046 , respectively). The corneal endothelial cell density of the eyes with a course of the disease of more than 1 year was lower than that of the eyes with a course of the disease less than 1 year, the coefficient of variation of the corneal endothelial cell area of the eyes with KP was higher than that of the eyes without KP, and the difference was statistically significant ( P = 0.003 and P = 0.030 , respectively). Conclusion. Corneal endothelial microscopy is one of the important methods for the detection of uveitis with high sensitivity. The change of morphological parameters of corneal endothelial cells is one of the important indexes to assist in the diagnosis of uveitis and can be further promoted in ophthalmological examination.

Are There Any Changes in Corneal Biomechanics and Central Corneal Thickness in Fuchs’ Uveitis? - Sen, Emine; Ozdal, Pinar; Balikoglu-Yilmaz, Melike; Nalcacioglu Yuksekkaya, Pinar; Elgin, Ufuk; Tirhiş, Mehmet Hakan; Ozturk, Faruk (Ocular Immunology and Inflammation, 2016)

TRANSIENT CHANGES IN SPECULAR APPEARANCE OF THE CORNEAL ENDOTHELIUM AND IN CORNEAL THICKNESS DURING ANTERIOR UVEITIS - Olsen, Thomas (Acta Ophthalmologica, 2009)

Corneal Endothelium in Herpetic Keratouveitis - Vannas, A.; Ahonen, R.; Makitie, J. (Archives of Ophthalmology, 1983)

Characteristics of corneal endothelial cells in Fuchs' heterochromic cyclitis - Alanko, Hannu I.; Vuorre, Ilkka; Saari, K. Matti (Acta Ophthalmologica, 2009)

Corneal Endothelium in Patients with Anterior Uveitis - Alfawaz, Abdullah M.; Holland, Gary N.; Yu, Fei; Margolis, Mathew S.; Giaconi, JoAnn A.; Aldave, Anthony J. (Ophthalmology, 2016)

The Association between Systemic Glucocorticoid Use and the Risk of Cataract and Glaucoma in Patients with Rheumatoid Arthritis: A Systematic Review and Meta-Analysis - Black, Rachel J.; Hill, Catherine L.; Lester, Susan; Dixon, William G. (PLOS ONE, 2016)

Steroid-induced glaucoma: Epidemiology, pathophysiology, and clinical management - Roberti, Gloria; Oddone, Francesco; Agnifili, Luca; Katsanos, Andreas; Michelessi, Manuele; Mastropasqua, Leonardo; Quaranta, Luciano; Riva, Ivano; Tanga, Lucia; Manni, Gianluca (Survey of Ophthalmology, 2020)

Changes in corneal endothelial cell density in patients with normal-tension glaucoma - Cho, Sung Woo; Kim, Joon Mo; Choi, Chul Young; Park, Ki Ho (Japanese Journal of Ophthalmology, 2009)

CORNEAL ENDOTHELIAL CELL DENSITY AFTER AN ATTACK OF ACUTE GLAUCOMA - Setälä, Kirsi (Acta Ophthalmologica, 2009)

Corneal Endothelial Changes in Primary Acute Angle-closure Glaucoma - Bigar, Francis; Witmer, Rudolf (Ophthalmology, 1982)

Corneal Status in Primary Angle-closure Glaucoma With a History of Acute Attack - Chen, Mei-Ju; Liu, Catherine Jui-Ling; Cheng, Ching-Yu; Lee, Shui-Mei (Journal of Glaucoma, 2012)

Changes in corneal endothelial cell density in patients with normal-tension glaucoma - Cho, Sung Woo; Kim, Joon Mo; Choi, Chul Young; Park, Ki Ho (Japanese Journal of Ophthalmology, 2009)

Prevalence and Visual Outcome of Glaucoma With Uveitis in a Thai Population - Pathanapitoon, Kessara; Smitharuck, Sarunya; Kunavisarut, Paradee; Rothova, Aniki (Journal of Glaucoma, 2017)

Analysis of Corneal Densitometry and Endothelial Cell Function in Fuchs Uveitis Syndrome - Simsek, Mert; Cakar Ozdal, Pinar; Cankurtaran, Mahmut; Ozdemir, Huseyin Baran; Elgin, Ufuk (Eye & Contact Lens: Science & Clinical Practice, 2021)

Corneal endothelium in unilateral Fuchs heterochromic iridocyclitis - Sravani, NGeetha; Mohamed, Ashik; Chaurasia, Sunita; Durgam, ShravyaSri; Murthy, SomasheilaI (Indian Journal of Ophthalmology, 2020)

Are There Any Changes in Corneal Biomechanics and Central Corneal Thickness in Fuchs’ Uveitis? - Sen, Emine; Ozdal, Pinar; Balikoglu-Yilmaz, Melike; Nalcacioglu Yuksekkaya, Pinar; Elgin, Ufuk; Tirhiş, Mehmet Hakan; Ozturk, Faruk (Ocular Immunology and Inflammation, 2016)

Evaluation of Retinal Nerve Fiber Layer Thickness in Eyes With Hypertensive Uveitis - Din, Norshamsiah M.; Taylor, Simon R. J.; Isa, Hazlita; Tomkins-Netzer, Oren; Bar, Asaf; Talat, Lazha; Lightman, Sue (JAMA Ophthalmology, 2014)

Retinal Nerve Fiber Layer Thickness Measurements: Uveitis, A Major Confounding Factor - Moore, Daniel B.; Jaffe, Glenn J.; Asrani, Sanjay (Ophthalmology, 2015)

Paradoxical Changes of Retinal Nerve Fiber Layer Thickness in Uveitic Glaucoma - Asrani, Sanjay; Moore, Daniel B.; Jaffe, Glenn J. (JAMA Ophthalmology, 2014)

Tool to Assess Risk of Bias in Case Control Studies - CLARITY Group, McMaster University (2023)

The Comprehensive R Archive Network - Institute for Statistics and Mathematics, WU (Wirtschaftsuniversität Wien). (The Comprehensive R Archive Network)

External Disease and Cornea

2020-2021 BASIC AND CLINICAL SCIENCE COURSE (BCSC), COMPLETE SET - AMERICAN ACADEMY OF OPHTHALMOLOGY (8, 2020)