TY - GEN
T1 - Electrocardiographic alterations associated with heart transplantation. Triggers, mechanisms and meaning
A1 - Figueroa-Bohórquez, David Mauricio
A1 - Benavides, Xiomara
A1 - Garzón, Luz
A1 - Espinel, Daniel
A1 - Suarez, Luis
A1 - Uribe, María
A1 - Gómez-Aristizabal, Linda
A1 - Lozano-Márquez, Eyner
Y1 - 2017///
KW - Arrhythmias
KW - Bradycardia
KW - Cardiac
KW - Heart transplantation
KW - Tachycardia (MeSH)
JF - Revista Facultad de Medicina
VL - 65
IS - 3
SP - 483
EP - 489
DO - 10.15446/revfacmed.v65n3.57498
N2 - Introduction: Heart rhythm disorders are associated with increased morbidity and mortality. However, triggers and implications in patients with heart transplantation are not clear. Objectives: The purpose of this research paper is to identify and explain the determinants for the onset of electrical conductivity alterations in patients with a heart transplant, as well as to describe the most common arrhythmias and their pathological implications. Materials and methods: A literature review was made in the PubMed online database for a total of 411 results. In addition, clinical practice guidelines on cardiac transplantation, cardiovascular electrophysiology and infective endocarditis were searched. Sixty articles related to the objectives of this study were chosen. Results: Surgical technique, heart denervation, sinus node trauma, graft rejection, endomyocardial biopsies and infections are the main factors that compromise organ viability and the life of transplanted patients. These factors can be observed as sinus rhythm disturbances. Conclusions: When a cardiac arrhythmia is detected, the medical team must provide a treatment that is not limited to symptomatic and sinus rhythm control. An active search of the etiology must be initiated since it may indicate an underlying pathological process.
ER -
TY - JOUR
T1 - Resolución 8430 de 1993
A1 - Ministerio de Salud
Y1 - 1993///
JF - Ministerio de Salud y Protección Social, República de Colombia
VL - 1993
IS - Octubre 4
SP - 1
EP - 19
SN - 0000100000030
DO - 10.2353/jmoldx.2008.080023
N2 - Por la cual se establecen las normas científicas, técnicas y administrativas para la investigación en salud.
ER -
TY - JOUR
T1 - Trasplante de corazón
A1 - H, Alberto Villegas; G, Juan C Jaramillo; J, Gloria Franco
Y1 - 2001///
JF - Revista colombiana de cardiologia Vol. 9 Nº 1 Julio/Agosto 2001
VL - 9
SP - 23
EP - 39
N2 - We want to present our experience in 132 cardiac transplants made in 129 patients during a 15 years time period from 1985 until now, in a specialized center in cardiac surgery. The mean age was 44.5 ± (11.8) for the group, with a gender relation of 81% for male population. 50.8% of patients was in functional class III or IV from NYHA. When there were compare the risks factors in the preoperative and intraoperative period against the post- operative complications it was found that the preoperative anticoagulation, prolonged perfusion time (longer than 180 minutes) and the pulmonary hypertension were the risk factors for postoperative complications including dead, having p values of 0.000 When the postoperative complications were analyzed, we found that the long perfusion time and the long drug support had a high statistic correlation with p value = 0.000 Analyzing the survival actuarial curves we found that the long term survival rate was 55.1%, being similar to the report of the International Society of Heart and Lung Trasplantation. (Rev.
ER -
TY - JOUR
T1 - A brain within the heart: A review on the intracardiac nervous system
A1 - Durães Campos, Isabel
A1 - Pinto, Vitor
A1 - Sousa, Nuno
A1 - Pereira, Vitor H.
Y1 - 2018///
KW - Autonomic nervous system
KW - Cardiovascular diseases
KW - Intracardiac ganglia
KW - Intracardiac nervous system
KW - Intracardiac neurons
PB - Elsevier
JF - Journal of Molecular and Cellular Cardiology
VL - 119
IS - December 2017
SP - 1
EP - 9
DO - 10.1016/j.yjmcc.2018.04.005
UR - https://doi.org/10.1016/j.yjmcc.2018.04.005
N2 - Cardiac function is under the control of the autonomic nervous system, composed by the parasympathetic and sympathetic divisions, which are finely tuned at different hierarchical levels. While a complex regulation occurs in the central nervous system involving the insular cortex, the amygdala and the hypothalamus, a local cardiac regulation also takes place within the heart, driven by an intracardiac nervous system. This complex system consists of a network of ganglionic plexuses and interconnecting ganglions and axons. Each ganglionic plexus contains numerous intracardiac ganglia that operate as local integration centres, modulating the intricate autonomic interactions between the extrinsic and intracardiac nervous systems. Herein, we summarize the current understanding on the intracardiac nervous system, and acknowledge its role in the pathophysiology of cardiovascular diseases.
ER -
TY - JOUR
T1 - Guías colombianas de cardiologia - Trasplante cardíaco
A1 - Sociedad colombiana de cardiología y cirugía cardiovascular
Y1 - 2009///
JF - Revista colombiana de cardiología
VL - 16
IS - 2
SP - 20
EP - 69
DO - 0120-5633
ER -
TY - JOUR
T1 - Decreto Numero 3380 De 1981
Y1 - 1981///
JF - DIARIO OFICIAL 35914 Miércoles 30 diciembre de 1981 DECRETO NUMERO 3380 DE 1981 (noviembre 30) por el cual se reglamenta la Ley 23 de 1981.
VL - 1981
IS - noviembre 30
SP - 1
EP - 6
UR - http://www.mineducacion.gov.co/1621/articles-103328_archivo_pdf.pdf
N2 - DIARIO OFICIAL 35914 Miércoles 30 diciembre de 1981 DECRETO NUMERO 3380 DE 1981 (noviembre 30) por el cual se reglamenta la Ley 23 de 1981. El Presidente de la república de Colombia, en ejercicio de las facultades constitucionales conferidas por el artículo 120, numeral 3 de la Constitución Política, DECRETA: Del juramento. Artículo 1º. Las autoridades académicas o sus delegados que confieran los títulos de médicos, tomarán el juramento médico. De las relaciones del médico con el paciente. Artículo 2º. En el trabajo institucional el derecho de libre elección del médico por parte del paciente estará sujeto a las posibilidades ofrecidas por cada institución. Artículo 3º. Para señalar la responsabilidad médica frente a los casos de emergencia o urgencia, entíendese por ésta, todo tipo de afección que ponga en peligro la vida o integridad de la persona y que requiera atención inmediata de acuerdo con el dictamen médico. Artículo 4º. Con excepción de los casos de urgencia, el médico podrá excusarse de asistir a un enfermo o interrumpir la prestación de sus servicios por las siguientes causas; a) Si se comprueba que le caso n corresponde a su especialidad, previo exámen general; b) Que el paciente reciba la atención de otro profesional que excluya la suya sin su previo consentimiento; c) Que el enfermo rehusé cumplir las indicaciones prescritas, entendiéndose por éstas, no sólo la formulación de tratamientos sino también los exámenes, juntas médicas, interconsultas y otras indicaciones generales que pro su no realización afecten la salud del paciente. Artículo 5º. El médico respetará la liberad del enfermo para prescindir de sus servicios, siempre y cuando el paciente tenga capacidad de manifestar su libre albedrío.
ER -
TY - JOUR
T1 - The Registry of the International Society for Heart and Lung Transplantation: Thirty-fourth Adult Heart Transplantation Report—2017; Focus Theme: Allograft ischemic time
A1 - Lund, Lars H.
A1 - Khush, Kiran K.
A1 - Cherikh, Wida S.
A1 - Goldfarb, Samuel
A1 - Kucheryavaya, Anna Y.
A1 - Levvey, Bronwyn J.
A1 - Meiser, Bruno
A1 - Rossano, Joseph W.
A1 - Chambers, Daniel C.
A1 - Yusen, Roger D.
A1 - Stehlik, Josef
Y1 - 2017///
PB - Elsevier Inc.
JF - Journal of Heart and Lung Transplantation
VL - 36
IS - 10
SP - 1037
EP - 1046
SN - 1557-3117 (Electronic) 1053-2498 (Linking)
DO - 10.1016/j.healun.2017.07.019
UR - http://dx.doi.org/10.1016/j.healun.2017.07.019
N2 - This year marks the 50th anniversary of the first heart transplant, performed in 1967. Since then, and in particular since the introduction of cyclosporine immunosuppression in the 1970s, heart transplantation has grown worldwide. This 34th adult heart transplant report is based on data submitted to the International Society for Heart and Lung Transplantation (ISHLT) Registry on 135,387 heart trans-plants in recipients of all ages (including 120,991 adult heart transplants) through June 30, 2016. With each year's report we now also provide more detailed analyses on a particular focus theme. Since 2013, these have been donor and recipient age, retransplantation, early graft failure, indication for transplant, and in 2017, allograft ischemic time.
ER -
TY - JOUR
T1 - AAEM minimonograph 48: Autonomic nervous system testing
A1 - Ravits, John M.
Y1 - 1997///
KW - 30:15 ratio
KW - Autonomic function
KW - Head-up tilt-table testing
KW - Quantitative sudomotor axon reflex
KW - Sinus arrhythmia
KW - Sweat imprint test
KW - Sympathetic skin response
KW - Thermoregulatory sweat test
KW - Valsalva ratio
JF - Muscle and Nerve
VL - 20
IS - 8
SP - 919
EP - 937
SN - 0148-639X (Print)\n0148-639x
DO - 10.1002/(SICI)1097-4598(199708)20:8<919::AID-MUS1>3.0.CO;2-9
N2 - The autonomic nervous system maintains internal homeosta-sis by regulating cardiovascular, thermoregulatory, gastrointestinal, genito-urinary, exocrine, and pupillary function. Testing and quantifying autonomic nervous system function is an important but difficult area of clinical neuro-physiology. Tests of parasympathetic cardiovagal regulation include heart rate analysis during standing (the 30:15 ratio), heart rate variation with deep breathing, and the Valsalva ratio. Tests of sympathetic adrenergic vascular regulation include blood pressure analysis while standing, the Valsalva maneuver, sustained handgrip, mental stress, and cold water immersion. Tests of sympathetic cholinergic sudomotor function include the sympathetic skin response, quantitative sudomotor axon reflex test, sweat box testing, and quantification of sweat imprints. Pupil function is tested pharmacol-ogically and with pupillographic techniques. Tests of gastrointestinal and genitourinary function do not satisfactorily isolate autonomic regulation from their other functions. The available tests have various sensitivities and ease of administration. They are typically administered in a battery of mult-iple tests, which improves sensitivity and reliability, and allows probing of various autonomic functions.
ER -
TY - JOUR
T1 - Variabilidad de la frecuencia cardiaca y alteraciones del ritmo cardiaco asociados a la terapia con células progenitoras en enfermedad cardiovascular
A1 - Orrego, Carlos M
A1 - Astudillo, Boris V
A1 - Senior, Juan M
A1 - Cuéllar, Francisco
A1 - Velásquez, Óscar
A1 - Velásquez, Margarita
Y1 - 2007///
KW - arritmias ventriculares
KW - cardiaca
KW - cardiopatía isquémica
KW - colombia
KW - de paúl -
KW - hospital universitario san vicente
KW - la médula ósea
KW - medellín
KW - sdnn
KW - trasplante autólogo derivado de
KW - trasplantes
KW - unidad cardiovascular y de
KW - universidad de antioquia
KW - variabilidad de la frecuencia
VL - 14
IS - 6
SP - 353
EP - 358
ER -
TY - JOUR
T1 - The 2016 International Society for Heart Lung Transplantation listing criteria for heart transplantation: A 10-year update
A1 - Mehra, Mandeep R.
A1 - Canter, Charles E.
A1 - Hannan, Margaret M.
A1 - Semigran, Marc J.
A1 - Uber, Patricia A.
A1 - Baran, David A.
A1 - Danziger-Isakov, Lara
A1 - Kirklin, James K.
A1 - Kirk, Richard
A1 - Kushwaha, Sudhir S.
A1 - Lund, Lars H.
A1 - Potena, Luciano
A1 - Ross, Heather J.
A1 - Taylor, David O.
A1 - Verschuuren, Erik A.M.
A1 - Zuckermann, Andreas
Y1 - 2016///
PB - Elsevier
JF - Journal of Heart and Lung Transplantation
VL - 35
IS - 1
SP - 1
EP - 23
SN - 1557-3117 (Electronic) 1053-2498 (Linking)
DO - 10.1016/j.healun.2015.10.023
UR - http://dx.doi.org/10.1016/j.healun.2015.10.023
N2 - ...patients with improved renalfunction after VAD support generally maintain renalfunction after HT. However...patients with severe renaldysfunction at the time...substance abuse, and psychosocialevaluation in candidate...Any patient for whom socialsupports are deemed insufficient...
ER -
TY - JOUR
T1 - The Past, Present and Future of Heart Transplantation
A1 - Kim, In-Cheol
A1 - Youn, Jong-Chan
A1 - Kobashigawa, Jon A.
Y1 - 2018///
JF - Korean Circulation Journal
VL - 48
IS - 7
SP - 565
EP - 565
DO - 10.4070/kcj.2018.0189
UR - https://synapse.koreamed.org/DOIx.php?id=10.4070/kcj.2018.0189
ER -
TY - JOUR
T1 - How heterogeneous is the cardiac autonomic innervation?
A1 - Momose, Mitsuru
A1 - Tyndale-Hines, Leisha
A1 - Bengel, Frank Michael
A1 - Schwaiger, Markus
Y1 - 2001///
JF - Basic Research in Cardiology
VL - 96
IS - 6
SP - 539
EP - 546
DO - 10.1007/s003950170004
UR - http://link.springer.com/10.1007/s003950170004
ER -
TY - JOUR
T1 - Resolucion Numero 1995 De 1999
A1 - Salud, Ministerio de
Y1 - 1999///
JF - Republica de colombia
VL - 1999
IS - Julio 8
SP - 1
EP - 8
SN - 4917754933
N2 - POR LA CUAL SE ESTABLECEN NORMAS PARA EL MANEJO DE LA HISTORIA CLINICA
ER -
TY - JOUR
T1 - Prognostic Significance of Heart Rate and its Long-term Trend in Cardiac Transplant Patients
A1 - Barge-Caballero, Eduardo
A1 - Jiménez-López, Jesús
A1 - Chávez-Leal, Sergio
A1 - Barge-Caballero, Gonzalo
A1 - Paniagua-Martin, María Jesús
A1 - Marzoa Rivas, Raquel
A1 - Grille-Cancela, Zulaika
A1 - Cuenca-Castillo, José Joaquín
A1 - Castro-Beiras, Alfonso
A1 - Crespo-Leiro, María G.
Y1 - 2015///
KW - Frecuencia cardiaca
KW - Heart rate
KW - Prognosis
KW - Pronóstico
KW - Transplantation
KW - Trasplante
JF - Revista espanola de cardiologia (English ed.)
VL - 68
IS - 11
SP - 943
EP - 950
DO - 10.1016/j.rec.2014.09.028
N2 - INTRODUCTION AND OBJECTIVES: The aim of the present study was to examine the prognostic significance of heart rate and its trend in heart transplantation.
METHODS: This observational study enrolled 170 patients who received a bicaval heart transplant between 1995 and 2005; all were in sinus rhythm. The resting heart rate was determined via electrocardiography at the end of the first posttransplant year and annually until the tenth year. Cox analysis was used to evaluate the incidence of adverse events with a mean (standard deviation) follow-up of 8.9 (3.1) years. The primary study end point was the composite outcome of death or graft dysfunction.
RESULTS: The resting heart rate at the end of the first posttransplant year was an independent predictor of the primary composite end point (hazard ratio=1.054; 95% confidence interval, 1.028-1.080; P<.001) and was significantly associated with total mortality (hazard ratio=1.058; 95% confidence interval, 1.030-1.087; P<.001) and mortality from cardiac causes (hazard ratio=1.069; 95% confidence interval, 1.026-1.113; P=.001), but not with graft dysfunction (hazard ratio=1.028; 95% confidence interval, 0.989-1.069; P=.161). For patients with a heart rate ≥ 105 or<90 bpm vs those with 90-104 bpm, the hazard ratios of the primary end point were 2.233 (95% confidence interval, 1.250-3.989; P=.007) and 0.380 (95% confidence interval, 0.161-0.895; P=.027), respectively. Heart rate tended to decrease in the first 10 years after transplantation (P=.001). Patients with a net increase in heart rate during follow-up showed a higher incidence of adverse events.
CONCLUSIONS: An elevated heart rate is an adverse prognostic marker after heart transplantation.
ER -
TY - JOUR
T1 - Ley 100 de 1993
A1 - Ministerio de salud y protección social
Y1 - 1993///
JF - Ley
VL - 100
IS - 41
SP - 500
EP - 500
SN - 9788578110796
DO - 10.1017/CBO9781107415324.004
UR - https://docs.supersalud.gov.co/PortalWeb/Juridica/Leyes/L0100_93.pdf
N2 - (Diciembre 23) Diario Oficial No. 41.148 de 23 de diciembre de 1993 Por la cual se crea el sistema de seguridad social integral y se dictan otras disposiciones NOTAS DE VIGENCIA: -Modificada por la Ley 1702 de 2013, "por la cual se crea la agencia nacional de seguridad vial y se dictan otras disposiciones", publicada en el Diario Oficial No. 49.016 de 27 de diciembre de 2013. -Modificado por la Ley 1607 de 2012, "por la cual se expiden normas en materia tributaria y se dictan otras disposiciones", publicada en el Diario Oficial No. 48.655 de 26 de diciembre de 2012 -Modificada por la Ley 1580 de 2012, "por la cual se crea la pensión familiar", publicada en el Diario Oficial No. 48.570 de 1 de octubre de 2012 -Modificado por la Ley 1562 de 2012, publicada en el Diario Oficial No. 48.488 de 11 de julio de 2012, "Por la cual se modifica el Sistema de Riesgos Laborales y se dictan otras disposiciones en materia de Salud Ocupacional" -Modificada por el Decreto 19 de 2012, publicado en el Diario Oficial No. 48.308 de 10 de enero de 2012, "Por el cual se dictan normas para suprimir o reformar regulaciones, procedimientos y trámites innecesarios existentes en la Administración Pública" -Modificada por el Decreto 4465 de 2011, publicado en el Diario Oficial No. 48.264 de 25 de noviembre de 2011, "Por el cual se adopta un mecanismo transitorio para garantizar la afiliación al Régimen Contributivo del Sistema General de Seguridad Social en Salud" -Modificada por la Ley 1450 de 2011, publicada en el Diario Oficial No. 48.102 de 16 de junio de 2011, "Por la cual se expide el Plan Nacional de Desarrollo, 2010-2014" -Modificada por la Ley 1438 de 2011, publicada en el Diario Oficial No. 47. 957 de 19 de enero de 2011, "Por medio de la cual se reforma el Sistema General de Seguridad Social en Salud y se dictan otras disposiciones" -Modificada por el Decreto 132 de 2010, publicado en el Diario Oficial No. 47.599 de 21 de enero de 2010, "Por el cual se establecen mecanismos para administrar y optimizar el flujo de recursos que financian el Régimen Subsidiado de Salud del Sistema General de Seguridad Social en Salud y se dictan otras disposiciones". Decreto expedido bajo el estado de emergencia social decretado mediante el Decreto 4975 de 2009. INEXEQUIBLE. 37. Modificada por el Decreto 131 de 2010, publicado en el Diario Oficial No. 47.599 de 21 de enero de 2010, "Por medio del cual se crea el Sistema Técnico Científico en Salud, se regula la autonomía profesional y se definen aspectos del aseguramiento del Plan Obligatorio de Salud y se dictan otras disposiciones". Decreto expedido bajo el estado de emergencia social decretado mediante el Decreto 4975 de 2009. INEXEQUIBLE. 36. Modificada por el Decreto 128 de 2010, publicado en el Diario Oficial No. 47.599 de 21 de enero de 2010, "Por medio del cual se regulan las prestaciones excepcionales en salud y se dictan otras disposiciones". Decreto expedido bajo el estado de emergencia social decretado mediante el Decreto 4975 de 2009. INEXEQUIBLE.
ER -
TY - JOUR
T1 - Early denervation and later reinnervation of the heart following cardiac transplantation: A review
A1 - Awad, Morcos
A1 - Czer, Lawrence S.C.
A1 - Hou, Margaret
A1 - Golshani, Sarah S.
A1 - Goltche, Michael
A1 - De Robertis, Michele
A1 - Kittleson, Michelle
A1 - Patel, Jignesh
A1 - Azarbal, Babak
A1 - Kransdorf, Evan
A1 - Esmailian, Fardad
A1 - Trento, Alfredo
A1 - Kobashigawa, Jon A.
Y1 - 2016///
KW - Electrophysiology
KW - Exercise
KW - Hemodynamics
KW - Imaging
KW - Nervous system autonomic
KW - Transplantation
JF - Journal of the American Heart Association
VL - 5
IS - 11
SP - 1
EP - 22
DO - 10.1161/JAHA.116.004070
ER -
TY - JOUR
T1 - Informe Ejecutivo Red De Donación Y Trasplantes
A1 - SALUD, INSTITUTO NACIONAL DE
Y1 - 2015///
KW - Mobile
KW - Named entity disambiguation
KW - Natural language processing
KW - News
KW - Recommender system
JF - CEUR Workshop Proceedings
VL - 1542
IS - 9
SP - 33
EP - 36
SN - 9788578110796
DO - 10.1017/CBO9781107415324.004
N2 - Predicting the binding mode of flexible polypeptides to proteins is an important task that falls outside the domain of applicability of most small molecule and protein−protein docking tools. Here, we test the small molecule flexible ligand docking program Glide on a set of 19 non-α-helical peptides and systematically improve pose prediction accuracy by enhancing Glide sampling for flexible polypeptides. In addition, scoring of the poses was improved by post-processing with physics-based implicit solvent MM- GBSA calculations. Using the best RMSD among the top 10 scoring poses as a metric, the success rate (RMSD ≤ 2.0 Å for the interface backbone atoms) increased from 21% with default Glide SP settings to 58% with the enhanced peptide sampling and scoring protocol in the case of redocking to the native protein structure. This approaches the accuracy of the recently developed Rosetta FlexPepDock method (63% success for these 19 peptides) while being over 100 times faster. Cross-docking was performed for a subset of cases where an unbound receptor structure was available, and in that case, 40% of peptides were docked successfully. We analyze the results and find that the optimized polypeptide protocol is most accurate for extended peptides of limited size and number of formal charges, defining a domain of applicability for this approach.
ER -
TY - JOUR
T1 - Sympathetic reinnervation of sinus node and left ventricle after heart transplantation in humans: Regional differences assessed by heart rate variability and positron emission tomography
A1 - Überfuhr, Peter
A1 - Frey, Axel W.
A1 - Ziegler, Sibylle
A1 - Reichart, Bruno
A1 - Schwaiger, Markus
Y1 - 2000///
JF - Journal of Heart and Lung Transplantation
VL - 19
IS - 4
SP - 317
EP - 323
SN - 1053-2498 (Print)\r1053-2498 (Linking)
DO - 10.1016/S1053-2498(00)00060-7
N2 - Background: Orthotopic heart transplantation (HTx) results in complete cardiac denervation. Reestablished partial sympathetic nerve function has been found in patients some years after HTx. However, the atrial and ventricular regional patterns of reinnervation have not been established. Methods: Two parallel methods were used to evaluate the regional restoration of sympathetic nerves in the myocardium. Patients were investigated with respect to ventricular reinnervation (VI) using positron emission tomography (PET) and the norepinephrine analogue C-11-hydroxyephedrine (HED). Tracer uptake was quantified using dynamic imaging protocols, yielding regional HED retention fraction. A regional value above 7%/minute ( ± 2.5 SD above the mean value of denervated hearts) was considered evidence of sympathetic reinnervation. Spectral analysis of heart rate variability (HRV) served as a quantitative marker for reinnervation at the sinus node (SI). Spectra of HRV during positive head-up tilt were calculated. The low frequency (LF) power spectral density (0.05 to 0.18 Hz) was evaluated. Results. After HTx (4.6 ± 3.9 years; range, 0.2 to 13.6 years), 38 patients (aged 50.9 ± 7.6 years; range, 37 to 65 years) were investigated by PET imaging and HRV. Twenty-two patients with a mean HED retention of 10.7 ± 2.6%/minute were classified as left ventricular reinnervated. Sixteen patients with a mean HED retention of 4.8 ± 0.8%/minute did not reach the threshold. The time difference after HTx was significant for these 2 groups, 5.3 ± 3.0 years vs 3.8 ± 4.7 years ( p < 0.05 ). The LF power spectral density of the ventricular reinnervated patients was 5.9 ± 8.6 ms2, and 1.8 ± 4.4 ms2(p <0.005 ) for those not reinnervated . Low frequency showed small values and narrow distribution for the patients not reinnervated, assuming sinus node denervation, and showed extended distribution for the reinnervated, suggesting a heterogeneous reinnervation pattern. Conclusion: Two non-invasive parallel methods were used to investigate regional reestablishment of cardiac nerves in the myocardium in HTx patients. Left VI assessed by PET imaging and SI by HRV was congruent in 60% of HTx patients. Lack of SI paralleled absence of VI. Our results suggest that partial VI occurs prior to SI. Copyright (C) 2000 International Society for Heart and Lung Transplantation.
ER -
TY - JOUR
T1 - Heart rate variability: Standards of Measurement, Physiological
A1 - Guidelines
Y1 - 1996///
KW - american
KW - autonomic nervous system
KW - co-sponsored by the north
KW - computers
KW - electrocardiography
KW - established by the board
KW - heart rate
KW - of the european
KW - risk factors
KW - society of cardiology and
KW - the task force was
JF - European Heart Journal
VL - 17
SP - 354
EP - 381
SN - 0195-668X
DO - 10.1161/01.CIR.93.5.1043
UR - http://www.mendeley.com/research/guidelines-heart-rate-variability-2/
N2 - The last two decades have witnessed the recognition of a significant relationship between the autonomic nervous system and cardiovascular mortality, including sudden cardiac death[1–4]. Experimental evidence for an associ- ation between a propensity for lethal arrhythmias and signs of either increased sympathetic or reduced vagal activity has encouraged the development of quantitative markers of autonomic activity. Heart rate variability (HRV) represents one of the most promising such markers. The apparently easy derivation of this measure has popularized its use. As many commercial devices now provide automated measurement of HRV, the cardiologist has been pro- vided with a seemingly simple tool for both research and clinical studies[5]. However, the significance and meaning of the many different measures of HRV are more complex than generally appreciated and there is a potential for incorrect conclusions and for excessive or unfounded extrapolations. Recognition of these problems led the European Society of Cardiology and the North American Society
ER -
TY - JOUR
T1 - Heart rate variability after heart transplantation : A 10-year longitudinal follow-up study
A1 - Cornelissen, Véronique A
A1 - Vanhaecke, Johan
A1 - Aubert, André E
A1 - Fagard, Robert H
Y1 - 2012///
PB - Japanese College of Cardiology
JF - Journal of Cardiology
VL - 59
IS - 2
SP - 220
EP - 224
DO - 10.1016/j.jjcc.2011.12.002
UR - http://dx.doi.org/10.1016/j.jjcc.2011.12.002
ER -
TY - JOUR
T1 - Reinnervation post-Heart transplantation
A1 - Grupper, Avishay
A1 - Gewirtz, Henry
A1 - Kushwaha, Sudhir
Y1 - 2017///
KW - heart transplantation
JF - European Heart Journal
IS - March
SP - ehw604
EP - ehw604
DO - 10.1093/eurheartj/ehw604
UR - https://academic.oup.com/eurheartj/article-lookup/doi/10.1093/eurheartj/ehw604
ER -
TY - JOUR
T1 - Honoring 50 Years of Clinical Heart Transplantation in Circulation
A1 - Stehlik, Josef
A1 - Kobashigawa, Jon
A1 - Hunt, Sharon A.
A1 - Reichenspurner, Hermann
A1 - Kirklin, James K.
Y1 - 2018///
KW - heart transplantation
KW - immunosuppression
KW - survival
JF - Circulation
VL - 137
IS - 1
SP - 71
EP - 87
DO - 10.1161/CIRCULATIONAHA.117.029753
UR - http://circ.ahajournals.org/lookup/doi/10.1161/CIRCULATIONAHA.117.029753
ER -
TY - GEN
T1 - Performance Limitations in Heart Transplant Recipients
A1 - Tucker, Wesley J
A1 - Beaudry, Rhys I
A1 - Haykowsky, Mark J
A1 - Samuel, T Jake
A1 - Nelson, Michael D
A1 - Halle, Martin
A1 - Baggish, Aaron L
KW - Physiology
KW - Sport Sciences
KW - cardiac reinnervation
KW - cardiovascular function
KW - exercise training
KW - peak oxygen uptake
KW - skeletal muscle function
JF - EXERCISE AND SPORT SCIENCES REVIEWS
VL - 46
IS - 3
SP - 144
EP - 151
SN - 00916331
UR - http://ez.urosario.edu.co/login?url=http://search.ebscohost.com/login.aspx?direct=true&db=edswsc&AN=000435347100003&lang=es&site=eds-live&scope=site
N2 - We hypothesize that the reduced peak aerobic power (peak VO2) after heart transplantation is due to impaired cardiovascular and skeletal muscle function, and its improvement with short-term (<= 1 yr) exercise training is primarily due to favorable skeletal muscle adaptations. Furthermore, the increased peak VO2 with long-term (>2 yr) training is primarily mediated by cardiac (sympathetic) reinnervation.
ER -
TY - JOUR
T1 - UK guidelines for referral and assessment of adults for heart transplantation
A1 - Banner, Nicholas R.
A1 - Bonser, Robert S.
A1 - Clark, Andrew L.
A1 - Clark, Stephen
A1 - Cowburn, Peter J.
A1 - Gardner, Roy S.
A1 - Kalra, Paul R.
A1 - McDonagh, Theresa
A1 - Rogers, Chris A.
A1 - Swan, Lorna
A1 - Parameshwar, Jayan
A1 - Thomas, Helen L.
A1 - Williams, Simon G.
Y1 - 2011///
JF - Heart
VL - 97
IS - 18
SP - 1520
EP - 1527
SN - 1468-201X (Electronic)\n1355-6037 (Linking)
DO - 10.1136/heartjnl-2011-300048
N2 - Patients with advanced heart failure have a dismal prognosis and poor quality of life. Heart transplantation provides an effective treatment for a subset of these patients. This article provides cardiologists with up-to-date information about referral for transplantation, the role of left ventricular assist devices prior to transplant, patient selection, waiting-list management and donor heart availability. Timing is of central importance; patients should be referred before complications (eg, cardiorenal syndrome or secondary pulmonary hypertension) have developed that will increase the risk of, or potentially contraindicate, transplantation. Issues related to heart failure aetiology, comorbidity and adherence to medical treatment are reviewed. Finally, the positive role that cardiologists can play in promoting and facilitating organ donation is discussed.
ER -
TY - JOUR
T1 - Código de Ética Médica. Colombia
A1 - Kraus, Arnoldo
Y1 - 1996///
KW - Ética médica
JF - Nexos
VL - 19
IS - 223
SP - 30
EP - 33
SN - 8433561219
N2 - Esta Secção visa ressaltar os aspectos éticos envolvidos em condutas adotadas em casos clínicos, de preferência reais. Faz-se a descrição de um caso clínico, solicitando-se a opinião de profissionais reconhecidamente competentes. Para garantir a utilidade social e acadêmica da Secção, os responsáveis solicitam e agradecem a contribuição dos leitores. Espera-se receber casos reais para discussão, comentários relativos às posições dos profissionais selecionados e informações que possibilitem o exame ético dessas mesmas posições.
ER -
TY - JOUR
T1 - Reinnervation of the transplanted human heart as evidenced from heart rate variability studies
A1 - Halpert, I.
A1 - Goldberg, A. D.
A1 - Levine, A. B.
A1 - Levine, T. B.
A1 - Kornberg, R.
A1 - Kelly, C.
A1 - Lesch, M.
Y1 - 1996///
JF - American Journal of Cardiology
VL - 77
IS - 2
SP - 180
EP - 183
SN - 0002-9149 (Print)\r0002-9149 (Linking)
DO - 10.1016/S0002-9149(96)90592-5
N2 - This study evaluated heart rate variability (HRV) after cardiac transplantation in humans in an attempt to test the hypothesis that cardiac reinnervation occurs in the post-transplant period. HRV was measured using 24-hour Holter recordings performed on 37 ambulant patients 1 to 122 months after cardiac transplantation. All patients were free of histologic rejection and were taking no medication likely to influence HRV. Time and frequency domain were analyzed and circadian rhythm of hourly average heart rate was calculated. HRV increased with time after the transplant. Compared with patients in the early post-transplant period, patients >36 months after transplant had lower 24-hour heart rates (86 vs 93 beats/min), an increased average of all 5-minute SDs of NN intervals (17.6 vs 11.3), and higher low- and high-frequency power. Ten of the 27 patients >3 years after transplantation had evidence of functional cardiac reinnervation. Compared with patients who had no reinnervation, these patients had increased circadian variability with lower nocturnal heart rates (76 vs 91 beats/min) and greater sympathetic activity during both daytime (natural logarithm sympathetic power-0.36 vs-1.45) and nighttime (natural logarithm sympathetic power -0.43 vs -1.98). Despite lower nocturnal heart rates, them was no HRV evidence for an increase in parasympathetic ability. Thus, patients late after cardiac transplantation have HRV evidence for an increase in sympathetic control of the heart.
ER -
TY - JOUR
T1 - Analysis of Heart Rate Variability With Electromyography in Heart Transplant Recipients
A1 - On, Arzu
A1 - Karapolat, Hale
A1 - Zoghi, Mehdi
A1 - Nalbantgil, Sanem
A1 - Yagdi, Tahir
A1 - Ozbaran, Mustafa
Y1 - 2009///
KW - Heart transplantation
KW - Rehabilitation
PB - Elsevier Inc.
JF - Archives of Physical Medicine and Rehabilitation
VL - 90
IS - 9
SP - 1635
EP - 1638
DO - 10.1016/j.apmr.2009.03.012
UR - http://dx.doi.org/10.1016/j.apmr.2009.03.012
N2 - On A, Karapolat H, Zoghi M, Nalbantgil S, Yagdi T, Ozbaran M. Analysis of heart rate variability with electromyography in heart transplant recipients. Objective: To investigate vagal parasympathetic functions by electromyographic R-R interval variation analyses in heart transplant recipients. Design: Cross-sectional and longitudinal study. Setting: Department of physical medicine and rehabilitation, university hospital. Participants: Early (n=8; <3mo) and late (n=17; >1y) heart transplant recipients and healthy volunteers (n=20) were included. Interventions: Not applicable. Main Outcome Measures: The R-R interval variations at rest and in response to deep breathing, Valsalva, and tilt/standup maneuvers were analyzed in all patient and control groups. Further, 8 early heart transplant recipients were followed up at the sixth and twelfth months after transplantation. Results: Compared with controls, both early and late transplant recipients had significantly lower R-R interval variation ratios (P<.05). There were no statistically significant differences between the early and late groups (P>.05). R-R interval variation ratios showed no significant changes from baseline (P>.025) in the early heart transplant recipients. Conclusions: The findings of the study suggest that parasympathetic activities are suppressed in the early stage after heart transplantation and do not significantly recover with time. The electromyographic analysis of R-R interval variation is a simple test that may offer an attractive alternative for routine evaluation of autonomic dysfunction in heart transplant recipients. © 2009 American Congress of Rehabilitation Medicine.
ER -
TY - BOOK
T1 - Heart Rate Variability
A1 - Electrophysiology, Task Force of the European Society
Y1 - 1996///
KW - Heart rate variability
KW - Sydämen sykevaihtelu
KW - atherosclerosis
KW - autonomic cardiac control
KW - autonomic nervous system
KW - autonominen hermosto
KW - metabolic syndrome
KW - metabolinen oireyhtymä
KW - reference values
KW - valtimonkovettumatauti
KW - viitearvot
JF - Circulation
VL - 93
IS - 5
SP - 1043
EP - 1065
SN - 0195-668X
DO - 10.1161/01.CIR.93.5.1043
UR - https://www.ahajournals.org/doi/10.1161/01.CIR.93.5.1043
ER -
TY - JOUR
T1 - Declaración de Helsinki
A1 - Valdespino Gómez, J. L.
A1 - García García, M. D.L.
Y1 - 2001///
JF - Gaceta Medica de Mexico
VL - 137
IS - 4
SP - 391
EP - 391
SN - 1549-1676 (Electronic)\r1549-1277 (Linking)
DO - 10.1177/1524839913507280
N2 - Principios éticos para las investigaciones médicas en seres humanos Adoptada por la 18.ª Asamblea Médica Mundial Helsinki, Finlandia, junio 1964 y enmendada por la 29.ª Asamblea Médica Mundial Tokio, Japón, octubre 1975 35.ª Asamblea Médica Mundial Venecia, Italia, octubre 1983 41.ª Asamblea Médica Mundial Hong Kong, septiembre 1989 48.ª Asamblea General Somerset West, Sudáfrica, octubre 1996 y la 52.ª Asamblea General Edimburgo, Escocia, octubre 2000 Nota de Clarificación del Párrafo 29, agregada por la Asamblea General de la AMM, Washington 2002 Nota de Clarificación del Párrafo 30, agregada por la Asamblea General de la AMM, Tokio 2004
ER -
TY - JOUR
T1 - Recurrence Plots: a New Tool for Quantification of Cardiac Autonomic Nervous System Recovery after Transplant
A1 - Takakura, Isabela Thomaz
A1 - Hoshi, Rosangela Akemi
A1 - Santos, Márcio Antonio
A1 - Pivatelli, Flávio Correa
A1 - Nóbrega, João Honorato
A1 - Guedes, Débora Linhares
A1 - Nogueira, Victor Freire
A1 - Frota, Tuane Queiroz
A1 - Castelo, Gabriel Castro
A1 - Godoy, Moacir Fernandes de
Y1 - 2017///
KW - autonomic nervous
KW - heart failure
KW - transplantation
JF - Brazilian Journal of Cardiovascular Surgery
VL - 32
IS - 4
SP - 245
EP - 252
DO - 10.21470/1678-9741-2016-0035
UR - http://www.bjcvs.org/index
N2 - Objective: To evaluate a possible evolutionary post-heart transplant return of autonomic function using quantitative and qualitative information from recurrence plots. Methods: Using electrocardiography, 102 RR tachograms of 45 patients (64.4% male) who underwent heart transplantation and that were available in the database were analyzed at different follow-up periods. The RR tachograms were collected from patients in the supine position for about 20 minutes. A time series with 1000 RR intervals was analyzed, a recurrence plot was created, and the following quantitative variables were evaluated: percentage of determinism, percentage of recurrence, average diagonal length, Shannon entropy, and sample entropy, as well as the visual qualitative aspect. Results: Quantitative and qualitative signs of heart rate variability recovery were observed after transplantation. Conclusion: There is evidence that autonomic innervation of the heart begins to happen gradually after transplantation. Quantitative and qualitative analyses of recurrence can be useful tools for monitoring cardiac transplant patients and detecting the gradual return of heart rate variability. Abbreviations, acronyms & symbols AF ApEn CD DET DFA ENTR HRV LAM Lmax Lmean REC RPs RR SampEn ShEn TT = Atrial fibrillation = Approximate entropy = Correlation dimension = Determinism = Detrended fluctuations analysis = Entropy = Heart rate variability = Laminarity = Maximum line = Average diagonal length = Recurrence = Recurrence plots = RR intervals = Sample entropy = Shannon entropy = Trapping time
ER -
TY - JOUR
T1 - Ley Estatutaria 1581 De 2012
A1 - Soediono, Budi
Y1 - 1989///
KW - icle
JF - Journal of Chemical Information and Modeling
VL - 53
IS - Octubre 17
SP - 160
EP - 160
SN - 9788578110796
DO - 10.1017/CBO9781107415324.004
N2 - Predicting the binding mode of flexible polypeptides to proteins is an important task that falls outside the domain of applicability of most small molecule and protein−protein docking tools. Here, we test the small molecule flexible ligand docking program Glide on a set of 19 non-α-helical peptides and systematically improve pose prediction accuracy by enhancing Glide sampling for flexible polypeptides. In addition, scoring of the poses was improved by post-processing with physics-based implicit solvent MM- GBSA calculations. Using the best RMSD among the top 10 scoring poses as a metric, the success rate (RMSD ≤ 2.0 Å for the interface backbone atoms) increased from 21% with default Glide SP settings to 58% with the enhanced peptide sampling and scoring protocol in the case of redocking to the native protein structure. This approaches the accuracy of the recently developed Rosetta FlexPepDock method (63% success for these 19 peptides) while being over 100 times faster. Cross-docking was performed for a subset of cases where an unbound receptor structure was available, and in that case, 40% of peptides were docked successfully. We analyze the results and find that the optimized polypeptide protocol is most accurate for extended peptides of limited size and number of formal charges, defining a domain of applicability for this approach.
ER -
TY - JOUR
T1 - Angina secundaria a lesión de tronco coronario izquierdo post trasplante cardiaco. Evidencias de reinervación simpática tardía
A1 - Riedemann S, Erick
A1 - Castro G, Pablo
A1 - Quintana F, Juan Carlos
A1 - Pérez P, Osvaldo
A1 - Mc-Nab M, Paul
Y1 - 2007///
KW - Coronary artery bypass
KW - Coronary disease
KW - Heart transplantation
JF - Revista Medica de Chile
VL - 135
IS - 12
SP - 1577
EP - 1581
N2 - We report a 56 years-old man presenting with chest pain with exercise, seven years after an orthotopic heart transplant. A coronary angiography showed an atherosclerotic lesion in the common left main coronary artery with more than 90 percent obstruction. The lesion was successfully treated with a transluminal angioplasty with stenting. A 131-1 metaiodobenylguanidine (MIBG) scan demonstrated sympathetic reinnervation. Sixteen months later, due to progression of allograft vasculopathy, coronary artery bypass was required.(AU)
ER -
TY - JOUR
T1 - The use of heart rate variability measures as indicators of autonomic nervous modulation must be careful in patients after orthotopic heart transplantation
A1 - Lu, Wan An
A1 - Chen, Gau Yang
A1 - Shih, Chun Che
A1 - Kuo, Cheng Deng
Y1 - 2016///
KW - Autonomic nervous system
KW - Heart rate variability
KW - Heart transplantation
KW - Re-innervation
PB - Springer Netherlands
JF - Journal of Clinical Monitoring and Computing
VL - 30
IS - 5
SP - 687
EP - 697
SN - 1573-2614 (Electronic)\r1387-1307 (Linking)
DO - 10.1007/s10877-015-9747-y
N2 - © 2015 The Author(s) The precise relation between heart rate variability (HRV) and autonomic re-innervation has not been established explicitly in patients after orthotopic heart transplantation (OHT), but can be inferred from the fact that the HRV is reduced immediately after OHT and may increase gradually with time. The aim of this study was to investigate the residual HRV in patients about 1–2 years after OHT, as compared with patients after coronary artery bypass graft (CABG) surgery. Thirteen patients who had received OHT and 14 patients who had received CABG surgery were recruited. HRV analysis was performed and the HRV measures in supine position were compared between these two groups of patients. We found that the mean (mRRI), standard deviation and coefficient of variation of RR intervals, total power, very low frequency power (VLFP), low frequency power, high frequency power (HFP), normalized VLFP (nVLFP) and low-/high-frequency power ratio in the OHT group were all significantly decreased, while the heart rate (HR) and normalized HFP (nHFP) were significantly increased, as compared with the CABG group. The decrease in HRV was more severe in the VLFP region. A smaller nVLFP and a greater nHFP were associated with a smaller mRRI and a larger HR in the OHT patients. The slope of the power law relation of HRV became positive in OHT patients, instead of negative in CABG patients. We conclude that patients after OHT have residual HRV which were characterized by severely depressed time and frequency domain HRV, increased HR and nHFP, decreased nVLFP, and positive slope of the power-law relation of HRV. The use of nHFP as the indicator of vagal modulation and the use of nVLFP as the indicator of renin-angiotensin modulation, thermoregulation and vagal withdrawal must be careful in the OHT patients.
ER -
TY - JOUR
T1 - Heart rate variability: a review
A1 - Rajendra, U
A1 - Ae, Acharya
A1 - Paul, K
A1 - Ae, Joseph
A1 - Kannathal, N
A1 - Choo, A E
A1 - Lim, Min
A1 - Jasjit, A E
A1 - Suri, S
KW - ANOVA test
KW - Approximate entropy
KW - Autonomic nervous system
KW - Correlation dimension
KW - Heart rate variability
KW - Hurst exponent
KW - Lyapunov exponent
KW - Phase space plot
KW - Poincare plot
KW - Recurrent plot
KW - Sample entropy
KW - Surrogate data
KW - Wavelet transform
DO - 10.1007/s11517-006-0119-0
N2 - Heart rate variability (HRV) is a reliable reflection of the many physiological factors modulating the normal rhythm of the heart. In fact, they provide a powerful means of observing the interplay between the sympathetic and parasympathetic nervous systems. It shows that the structure generating the signal is not only simply linear, but also involves nonlinear contributions. Heart rate (HR) is a nonstationary signal; its variation may contain indicators of current disease, or warnings about impending cardiac diseases. The indicators may be present at all times or may occur at random-during certain intervals of the day. It is strenuous and time consuming to study and pinpoint abnormalities in voluminous data collected over several hours. Hence, HR variation analysis (instanta-neous HR against time axis) has become a popular noninvasive tool for assessing the activities of the autonomic nervous system. Computer based analytical tools for in-depth study of data over daylong intervals can be very useful in diagnostics. Therefore, the HRV signal parameters, extracted and analyzed using computers , are highly useful in diagnostics. In this paper, we have discussed the various applications of HRV and different linear, frequency domain, wavelet domain, nonlinear techniques used for the analysis of the HRV.
ER -
TY - ICOMM
T1 - Trasplante de corazón | Clínica Cardio VID
UR - https://www.cardiovid.org.co/index.php/trasplante-de-corazon/
ER -
TY - RPRT
T1 - La palpitante historia de un trasplante
A1 - Clinica cardiovascular
A1 - Congregación mariana
Y1 - 2010///
UR - https://www.cardiovid.org.co/wp-content/uploads/2014/10/libro252.pdf
ER -
TY - ICOMM
T1 - Trasplante de corazón y Clínica de Falla Cardiaca | Clínica Shaio
UR - https://www.shaio.org/trasplante-de-corazon-y-clinica-de-falla-cardiaca
ER -
TY - JOUR
T1 - Unexpected Interaction Between /3-Adrenergic Blockade and Heart Rate Variability Before and After Myocardial Infarction A Longitudinal Study in Dogs at High and Low Risk for Sudden Death
A1 - Adamson, Philip B
A1 - Huang, Ming H
A1 - Vanoli, Emilio
A1 - Foreman, Robert D
A1 - Schwartz, Peter J
A1 - Hull, Stephen S
Y1 - 1994///
UR - http://ahajournals.org
ER -
TY - JOUR
T1 - Can power spectral analysis of heart rate variability identify a high risk subgroup of congestive heart failure patients with excessive sympathetic activation? A pilot study before and after heart transplantation
A1 - Mortara, Andrea
A1 - Teresa, Maria
A1 - Rovere, La
A1 - Signorini, Maria Gabriella
A1 - Pantaleo, Paolo
A1 - Pinna, Gianni
A1 - Martinelli, Luigi
A1 - Ceconi, Claudio
A1 - Cerutti, Sergio
A1 - Tavazzi, Luigi
A1 - Mortara, A
A1 - Pantaleo, P
A1 - Pinna, G
A1 - Tavazzi, L
Y1 - 1994///
JF - Br Heart3r
VL - 71
SP - 422
EP - 430
UR - http://heart.bmj.com/
N2 - Background and objectives-Autonomic dysfunction seems to be involved in the progression and prognosis of severe congestive heart failure. Parasympa-thetic activity can still be abnormal 4-8 weeks after haemodynamic improvement by heart transplantation. To identify patients in heart failure with a more pronounced neural derangement and to analyse the changes in sympathetic and parasympathetic activity soon after heart transplantation, spectral indices of heart rate variability were assessed in 30 patients in severe heart failure and in 13 patients after heart transplantation; a group of 15 age-matched subjects served as controls. Methods and results-Heart rate variability was assessed by standard electro-cardiography (ECG) in patients in heart failure and by oesophageal ECG in patients after heart transplantation. Compared with controls, the mean RR interval and total power were reduced in heart failure. The 30 patients showed two different patterns of heart rate variability: in 14 no power was detected in the low frequency band (0.03-0.15 Hz) (LF) and total power was mainly concentrated in the high frequency band (0.15-0-45 Hz) (HF), whereas in the remaining 16 patients power in the LF band was increased and power in HF band was reduced compared with the controls. Patients with undetectable LF had a lower mean RR interval and total power (745(25) v 864(36) ms, p < 0 05; 118(16) v 902(202) ms', p < 0.001), higher concentration of plasma noradrenaline (635(75) v 329(54) pg/ml, p < 0.05), and worse clinical status and prognosis (4 deaths v no deaths at 6 month follow up) than patients with a dominant LF band. In the post-transplant patients both the mean PP interval of the remnant atrium and total power resembled results in the patients with heart failure; in 7 of the 13 post-transplant patients no power was detectable in the LF band: when both HF and LF power were present the results resembled those in the 16 patients in heart failure. Conclusions-These data suggest that in more advanced stages of congestive heart failure, power spectral analysis of heart rate variability allows identification of a subgroup of patients with higher sympathetic activation and poorer clinical status who are at major risk of adverse events. In the short term after cardiac transplantation the spectral profile of the rhythm variability of the remnant atrium was not improved, suggesting that parasympathetic withdrawal and sympathetic hyperactivity persist, despite the restoration of ventricular function. (Br Heart J7 1994;71:422-430) Heart failure in both experimental and clinical settings is associated with considerable neuro-humoral excitation, resulting in abnormal autonomic control of cardiovascular function. Increased sympathetic activity and plasma concentrations of noradrenaline.' 2 parasym-pathetic withdrawal,3-5 and impaired barore-flex gain68 have been reported. This excessive neurohumoral activation is involved in progression of heart failure and in prognosis. Analysis of heart rate variability is regarded a valid technique to assess non-invasively the sympathovagal balance of the heart. Frequency domain analysis of heart rate fluctuations identifies the relative influence of the two neural limbs that regulate heart rhythm.9-"1 When this technique was used to study patients in congestive heart failure the results did not accord, perhaps because methods and patient selection differed.45 Parasympathetic activity assessed by time domain analysis of the variability of the sinus rhythm in the remnant remained subnormal 4-8 weeks after cardiac transplantation despite restoration of normal left ventricular function.'2 There are no data on frequency domain measurements of recipient sinus rhythm variability. Such analysis might give better discrimination of the role of sympathetic activity in the recovery of autonomic function. In our present study we tested the hypothesis that power spectrum analysis of heart rate variability in congestive heart failure may identify patients with a more pronounced 422 group.bmj.com on June 9, 2015-Published by http://heart.bmj.com/ Downloaded from
ER -
TY - ICOMM
T1 - Guía Elaboración Consentimiento Informado
A1 - Organización Mundial de la Salud (OMS)
UR - http://cec.ufro.cl/index.php/modelos-tipo?id=10
ER -
TY - JOUR
T1 - Perioperative mortality is the Achilles heel for cardiac transplantation in adults with congenital heart disease: Evidence from analysis of the UNOS registry
A1 - Shah, Dipesh K.
A1 - Deo, Salil V.
A1 - Althouse, Andrew D.
A1 - Teuteberg, Jeffery J.
A1 - Park, Soon J.
A1 - Kormos, Robert L.
A1 - Burkhart, Harold M.
A1 - Morell, Victor O.
Y1 - 2016///
JF - Journal of Cardiac Surgery
VL - 31
IS - 12
SP - 755
EP - 764
DO - 10.1111/jocs.12857
N2 - BACKGROUND: Adults with congenital heart disease may present with end-stage heart failure necessitating orthotopic heart transplant (OHT). We sought to review the United Network for Organ Sharing (UNOS) experience with this unique cohort focusing on surgical outcomes and survival. METHODS: From the UNOS registry, 737 adult congenital heart disease recipients (ACHDR) out of 26,993 OHT patients (2.7%) who underwent OHT were studied to analyze early and late outcomes and compared to non-congenital recipients (NCR) over a 15-year period (2000-2014). RESULTS: More ACHDR underwent OHT in the recent-era (3.1%; 2010-2014) as compared to the initial-era (2.5%; 2000-2004; p=0.03). ACHDR were more likely female (40% vs. 24%; p10%; p<0.01, and were listed for a longer time (249 vs. 181 days; p<0.01). When compared to the NCR in the same period, the ACHDR cohort had longer postoperative length of stay (27 vs. 20 days; p<0.01), higher operative mortality (11.5% vs. 4.6% p<0.001), higher incidence of primary graft dysfunction (4.3% vs. 2.6%; p<0.01), and higher need for dialysis (20% vs. 9%; p<0.01). Primary graft dysfunction is the most common cause of death in (5.8%) ACHDR. Although short-term survival is poorer, long-term survival of ACHDR was found to be equivalent or better than NCR in long term. CONCLUSIONS: Perioperative morbidity and mortality adversely affects short-term survival in ACHDR. ACHDR who survive the first post-transplant year have equivalent or better long-term survival than NCR. Copyright © 2016 Wiley Periodicals, Inc.
ER -
TY - JOUR
T1 - Visualization of heart rate variability of long-term heart transplant patient by transition networks: A Case Report
A1 - Wdowczyk, Joanna
A1 - Makowiec, Danuta
A1 - Dorniak, Karolina
A1 - Gruchala, Marcin
Y1 - 2016///
KW - Arrhythmias
KW - Cardiac autonomic modulation
KW - Heart rate variability
KW - Heart transplantation
KW - Hearth rhythm dynamics
KW - Reinnervation
JF - Frontiers in Physiology
VL - 7
IS - MAR
SP - 2012
EP - 2017
DO - 10.3389/fphys.2016.00079
N2 - We present a heart transplant patient at his 17th year of uncomplicated follow-up. Within a frame of routine check out several tests were performed. With such a long and uneventful follow-up some degree of graft reinnervation could be anticipated. However, the patient's electrocardiogram and exercise parameters seemed largely inconclusive in this regard. The exercise heart rate dynamics were suggestive of only mild, if any parasympathetic reinnervation of the graft with persisting sympathetic activation. On the other hand, traditional heart rate variability (HRV) indices were inadequately high, due to erratic rhythm resulting from interference of the persisting recipient sinus node or non-conducted atrial parasystole. New tools, originated from network representation of time series, by visualization short-term dynamical patterns, provided a method to discern HRV increase due to reinnervation from other reasons.
ER -
TY - JOUR
T1 - Early parasympathetic reinnervation is not related to reconnection of major branches of the vagus nerve after heart transplantation
A1 - Lee, So Ryoung
A1 - Kang, Do Yoon
A1 - Cho, Youngjin
A1 - Cho, Hyun Jai
A1 - Lee, Hae Young
A1 - Choi, Eue Keun
A1 - Oh, Seil
Y1 - 2016///
KW - Heart transplantation
KW - Parasympathetic
KW - Reinnervation
KW - Vagus nerve
JF - Korean Circulation Journal
VL - 46
IS - 2
SP - 197
EP - 206
DO - 10.4070/kcj.2016.46.2.197
N2 - BACKGROUND AND OBJECTIVES Bicaval heart transplantation (HTx) may promote parasympathetic reinnervation. However, the prevalence and timing of reinnervation have not been fully investigated. Heart rate variability (HRV) and direct vagal stimulation were used to evaluate the presence of parasympathetic reinnervation after bicaval HTx. SUBJECTS AND METHODS A total of 21 patients (time after HTx 0.52-4.41 years, mean 1.8±1.2 years) who received a bicaval HTx was enrolled. Reinnervation was evaluated using HRV values from 24-hour Holter recordings. A cross-sectional analysis of the HRV at 0.5-1, 1-2, and >2 years after HTx was performed. We also applied high-frequency electrical stimulation (16.7 Hz, 1 msec pulse width, ≤10 V) to the cardiac branches of the vagus nerve at the level of the superior vena cava in eight patients at 6 and 12 months after HTx. RESULTS The degree of parasympathetic reinnervation corresponded to the time after HTx. The HRV analysis revealed that the root mean square of the successive differences between consecutive RR-intervals (RMSSD) and high-frequency power were significantly higher during the late period (>2 years) compared with the early period (0.5-1 year) after HTx. None of the eight patients who underwent direct vagal stimulation responded during the stimulation at 6 and 12 months, whereas incremental trends in HRV parameters were observed, which indicated that parasympathetic reinnervation began within 1 year after HTx. CONCLUSION Parasympathetic reinnervation seemed to begin in the early period (<1 year) after bicaval HTx. Reconnection of major branches of the vagus nerve may not be related to early reinnervation.
ER -
TY - JOUR
T1 - Parasympathetic reinnervation accompanied by improved post-exercise heart rate recovery and quality of life in heart transplant recipients.
A1 - Imamura, Teruhiko
A1 - Kinugawa, Koichiro
A1 - Okada, Ikuko
A1 - Kato, Naoko
A1 - Fujino, Takeo
A1 - Inaba, Toshiro
A1 - Maki, Hisataka
A1 - Hatano, Masaru
A1 - Kinoshita, Osamu
A1 - Nawata, Kan
A1 - Kyo, Shunei
A1 - Ono, Minoru
Y1 - 2015///
KW - Adult
KW - Exercise
KW - Exercise Test
KW - Exercise Tolerance
KW - Female
KW - Follow-Up Studies
KW - Heart
KW - Heart Failure
KW - Heart Rate
KW - Heart Transplantation
KW - Humans
KW - Male
KW - Middle Aged
KW - Oxygen Consumption
KW - Parasympathetic Nervous System
KW - Quality of Life
KW - Recovery of Function
KW - Surveys and Questionnaires
KW - Time Factors
KW - Treatment Outcome
KW - Young Adult
KW - innervation
KW - physiology
KW - physiopathology
KW - surgery
JF - International heart journal
VL - 56
IS - 2
SP - 180
EP - 185
SN - 1349-2365
DO - 10.1536/ihj.14-292
N2 - Although sympathetic reinnervation is accompanied by the improvement of exercise tolerability during the first years after heart transplantation (HTx), little is known about parasympathetic reinnervation and its clinical impact. We enrolled 21 recipients (40 +/- 16 years, 71% male) who had received successive cardiopulmonary exercise testing at 6 months, and 1 and 2 years after HTx. Exercise parameters such as peak oxygen consumption or achieved maximum load remained unchanged, whereas recovery parameters including heart rate (HR) recovery during 2 minutes and the delay of peak HR, which are influenced by parasympathetic activity, improved significantly during post-HTx 2 years (P < 0.05 for both). HR variability was analysed at post-HTx 6 months in 18 recipients, and high frequency power, representing parasympathetic activity, was significantly associated with the 2 recovery parameters (P < 0.05 for all). We also assessed quality of life using the Minnesota Living with Heart Failure (HF) Questionnaire at post-HTx 6 months and 2 years in the same 18 recipients, and those with improved recovery parameters enjoyed a better HF-specific quality of life (P < 0.05 for both). In conclusion, parasympathetic reinnervation emerges along with improved post-exercise recovery ability of HR and quality of life during post-HTx 2 years.
ER -
TY - JOUR
T1 - Evidence for differential sympathetic and parasympathetic reinnervation after heart transplantation in humans
A1 - Tio, René A.
A1 - Reyners, An K.L.
A1 - Van Veldhuisen, Dirk J.
A1 - Van den Berg, Maarten P.
A1 - Brouwer, René M.H.J.
A1 - Haaksma, Jaap
A1 - Smit, Andries J.
A1 - Crijns, Harry J.G.M.
Y1 - 1997///
KW - Autonomic testing
KW - Heart rate variability
KW - Heart transplantation
KW - Human
KW - Reinnervation
JF - Journal of the Autonomic Nervous System
VL - 67
IS - 3
SP - 176
EP - 183
SN - 0165-1838
DO - 10.1016/S0165-1838(97)00104-5
N2 - During heart transplantation (HTX) all neural connections are severed. In humans, signs of autonomic reinnervation have been found. In this study non-invasive tests were used to compare signs of sympathetic and parasympathetic reinnervation. Non-invasive autonomic function tests and heart rate variability parameters (HRV; 24 h electrocardiographic registration) were used to investigate signs of reinnervation. 16 HTX patients (14 males) were compared with age- and sex-matched controls. Parasympathetic heart rate changes in HTX compared to controls were attenuated during the diving test, deep breathing, the Valsalva maneuver and standing up but not during carotid sinus massage. Sympathetic heart rate increases were lower during the cold presser test and mental stress. The blood pressure responses were comparable to the control group, but not during active standing and tilting. This finding suggests an obligatory 'blood pressure' role for the innervated heart in these two tests. All HRV parameters were lower in HTX. One or more normal parasympathetic responses were found in 13 out of 16 patients versus 4 out of 16 with normal sympathetic responses (p < 0.05). Heart rate variations were less in case of a higher donor age, and higher in case of a longer time after HTX. Parasympathetic signs of reinnervation are more common than sympathetic signs of reinnervation. A higher donor age reduces signs of reinnervation. If the sympatho-vagal balance is a prognostic factor in HTX patients as it is in other cardiac diseases these findings are clinically relevant.
ER -
TY - ICOMM
T1 - Donación y trasplantes de órganos
UR - https://www.minsalud.gov.co/salud/MT/Paginas/donacion-y-trasplantes-de-organos.aspx
ER -
TY - JOUR
T1 - Absence of Parasympathetic Control of Heart Rate After Human Orthotopic Cardiac Transplantation
A1 - Arrowood, James A.
A1 - Minisi, Anthony J.
A1 - Goudreau, Evelyne
A1 - Davis, Annette B.
A1 - King, Anne L.
Y1 - 1997/11//
KW - autonomic
KW - heart rate
KW - nervous system, autonomic
KW - reflex
KW - transplantation
KW - vagus nerve
PB - Lippincott Williams & Wilkins
JF - Circulation
VL - 96
IS - 10
SP - 3492
EP - 3498
DO - 10.1161/01.CIR.96.10.3492
UR - https://www.ahajournals.org/doi/abs/10.1161/01.cir.96.10.3492
N2 - Background Partial reinnervation of cardiac sympathetic nerves has been observed after heart transplantation; we hypothesized that parasympathetic control to the heart after transplantation may ret...
ER -
TY - JOUR
T1 - Long-Term Assessment of Heart Rate Variability in Cardiac Transplant Recipients
A1 - Keeley, Ellen C
A1 - Toth, Zoltan K
A1 - Goldberg, A David
A1 - Wiener, Michael A
Y1 - 2000///
JF - J Heart Lung Transplant
VL - 19
SP - 310
EP - 312
N2 - Sympathetic and parasympathetic reinnervation of the transplanted heart were evaluated by assessing time and frequency domain measurements of heart rate variability at 5 and 8 years. Continuous 24-hour ECG measurements were performed in 13 patients (57 6 months and 90 7 months) after orthotopic cardiac transplantation and in 22 healthy age and gender-matched controls, and were analyzed for heart rate variability in the time and frequency domains. Heart rate variability measures reflective of sympathetic reinnervation were sub-normal at 5 years and unchanged at 8 years: those reflective of parasympathetic reinnervation were absent. Heart rate variability (HRV), the measurement of the beat-to-beat variation in heart rate provides a non-invasive means to quantify the influence of the autonomic nervous system on the heart. Spectral analysis of HRV allows distinction between frequencies related to respiration and vagal activity (high frequency), and those related mainly to sympathetic activity (low frequency). The balance between the sympathetic and parasympathetic influence on cardiac function, as measured by HRV, has been shown to be abnormal in patients after heart transplanta-tion. 1 Cardiac transplantation results in complete de-nervation of the donor heart. As a result of dener-vation, HRV is undetectable early after heart trans-plantation. 1-2 Whereas in canine models, both sympathetic and parasympathetic reinnervation occur within 6 months after heart transplantation, 3-4 studies of human cardiac transplantation recipients have yielded conflicting results. 5-9 In the present study, we hypothesized that 1) the sympathetic influence on the heart continues to increase beyond 3 years after heart transplantation, approaching normal levels; and 2) the transplanted heart becomes innervated by the parasympathetic nervous system beyond 3 years after transplantation. To test these hypotheses, the sympathetic and para-sympathetic influence on the transplanted heart were evaluated by obtaining time and frequency domain measurements of HRV in each of 13 patients 5 and 8 years after heart transplantation. METHODS The study group consisted of 13 patients who underwent orthotopic cardiac transplantation. Each patient underwent 24-hour continuous ECG monitoring for HRV analysis at 57 6 months and again 90 7 months after heart transplantation. Average age of the patients was 46 7 years. In addition to immunosuppressive medications, all were taking angiotensin-converting enzyme inhibitors and calcium channel blockers. None received a beta-agonist, beta-antagonist, clonidine or anti-arrhyth-From the Henry Ford Heart and Vascular Institute,
ER -
TY - JOUR
T1 - Sympathetic reinnervation 1 year after heart transplantation, assessed using iodine-123 metaiodobenzylguanidine imaging.
A1 - F, Buendia-Fuentes
A1 - L, Almenar
A1 - C, Ruiz
A1 - JL, Vercher
A1 - I, Sánchez-Lázaro
A1 - L, Martínez-Dolz
A1 - J, Navarro
A1 - P, Bello
A1 - A, Salvador
Y1 - 2011/07//
KW - Europe PMC
KW - Europe PubMed Central
KW - ORCIDs
KW - REST APIs
KW - abstracts
KW - bioinformatics
KW - biological patents
KW - biomedical journals
KW - biomedical research
KW - citation networks
KW - citation search
KW - clinical guidelines
KW - full text
KW - journal articles
KW - life sciences
KW - literature search
KW - open access
KW - research articles
KW - text mining
JF - Transplantation Proceedings
VL - 43
IS - 6
SP - 2247
EP - 2248
DO - 10.1016/J.TRANSPROCEED.2011.05.020
UR - https://europepmc.org/article/med/21839246
N2 - Complete allograft denervation occurs during heart transplantation (HT). Partial ventricular sympathetic reinnervation that may develop after transplantation can be measured using iodine-123 meta iodobenzylguanidine (MIBG) uptake. Previous studies have suggested that reinnervation is likely to be a slow process, only occurring after 1 year posttransplantation. However, the reinnervation prevalence at 1 year after HT remains unknown. This study sought to determine sympathetic reinnervation measured by MIBG at 12 months after surgery. We performed serial cardiac MIBG imaging in 45 cardiac transplant recipients, including 32 males and 13 females, early (2 months) and late (12 months) after the operation. The intensity of myocardial MIBG uptaken was quantified by heart-to-mediastinum ratios (HMR). Reinnervation was considered when the HMR was >1.3. HMR was significantly higher at 12 months: 1.16 ± 0.10 at 2 vs 1.30 ± 0.15 at 12 months (P <.001). Eighteen (40%) of 45 subjects developed visible cardiac MIBG uptake at 1 year after transplantation with HMR >1.3. In conclusion, partial sympathetic reinnervation increases with time after HT; it was seen in 40% of patients at 1 year after the operation. © 2011 by Elsevier Inc. All rights reserved.
ER -
TY - JOUR
T1 - RR variability in healthy, middle-aged persons compared with patients with chronic coronary heart disease or recent acute myocardial infarction
A1 - Bigger, J. Thomas
A1 - Fleiss, Joseph L.
A1 - Steinman, Richard C.
A1 - Rolnitzky, Linda M.
A1 - Schneider, William J.
A1 - Stein, Phyllis K.
Y1 - 1995/04//
KW - aging
KW - electrocardiography
KW - heart rate
KW - nervous system
KW - sinoatrial node
KW - spectrum analysis
PB - Lippincott Williams and Wilkins
JF - Circulation
VL - 91
IS - 7
SP - 1936
EP - 1943
DO - 10.1161/01.CIR.91.7.1936
N2 - Background: The purpose of this investigation was to establish normal values of RR variability for middle-aged persons and compare them with values found in patients early and late after myocardial infarction. We hypothesized that presence or absence of coronary heart disease, age, and sex (in this order of importance) are all correlated with RR variability. Methods and Results: To determine normal values for RR variability in middle-aged persons, we recruited a sample of 274 healthy persons 40 to 69 years old. To determine the effect of acute myocardial infarction RR variability, we compared measurements of RR variability made 2 weeks after myocardial infarction (n=684) with measurements made on age- and sex-matched middle- aged subjects with no history of cardiovascular disease (n=274). To determine the extent of recovery of RR variability after myocardial infarction, we compared measurements of RR variability made in the group of healthy middle- aged persons with measurements made in 278 patients studied 1 year after myocardial infarction. We performed power spectral analyses on continuous 24- hour ECG recordings to quantify total power, ultralow-frequency (ULF) power, very-low-frequency (VLF) power, low-frequency (LF) power, high-frequency (HF) power, and the ratio of LF to HF (LF/HF) power. Time-domain measures also were calculated. All measures of RR variability were significantly and substantially lower in patients with chronic or subacute coronary heart disease than in healthy subjects. The difference from normal values was much greater 2 weeks after myocardial infarction than 1 year after infarction, but the fractional distribution of total power into its four component bands was similar for the three groups. In healthy subjects, ULF power did not change significantly with age; VLF, LF, and HF power decreased significantly as age increased. Patients with chronic coronary heart disease showed little relation between power spectral measures of RR variability and age. Patients with a recent myocardial infarction showed a strong inverse relation between VLF, LF, and HF power and age and a weak inverse relation between ULF power and age. ULF power best separates the healthy group from either of the two coronary heart disease groups. Differences in RR variability between men and women were small and inconsistent among the three groups. Conclusions: All measures of RR variability were significantly and substantially higher in healthy subjects than in patients with chronic or subacute coronary heart disease. The difference between healthy middle-aged persons and those with coronary heart disease was much greater 2 weeks after myocardial infarction than 1 year after infarction, but the fractional distribution of total power into its four component bands was similar for the healthy group and the two coronary heart disease groups. Values of RR variability previously reported to predict death in patients with known chronic coronary heart disease are rarely (≃1%) found in healthy middle-aged individuals. Thus, when measures of RR variability are used to screen groups of middle-aged persons to identify individuals who have substantial risk of coronary deaths or arrhythmic events, misclassification of healthy middle-aged persons should be rare.
ER -
TY - JOUR
T1 - No Title
A1 - Ewing, D J
A1 - Borsey, D Q
A1 - Bellavere, F
A1 - Clarke, B F
A1 - DJ, Ewing
A1 - DQ, Borsey
A1 - F, Bellavere
A1 - BF, Clarke
Y1 - 1981/07//
KW - Adult
KW - Aged
KW - B F Clarke
KW - Computers
KW - D J Ewing
KW - D Q Borsey
KW - Diabetes mellitus
KW - Diabetic Neuropathies / physiopathology*
KW - Female
KW - Heart / innervation*
KW - Heart / physiopathology
KW - Heart Rate*
KW - Humans
KW - MEDLINE
KW - Male
KW - Middle Aged
KW - NCBI
KW - NIH
KW - NLM
KW - National Center for Biotechnology Information
KW - National Institutes of Health
KW - National Library of Medicine
KW - Non-U.S. Gov't
KW - PubMed Abstract
KW - R-R interval variation
KW - Research Support
KW - Respiration
KW - autonomic neuro-pathy
KW - doi:10.1007/BF03216217
KW - pmid:7274613
KW - tests of autonomic function
PB - Diabetologia
JF - Diabetologia
VL - 21
IS - 1
SP - 18
EP - 24
DO - 10.1007/BF03216217
UR - https://pubmed.ncbi.nlm.nih.gov/7274613/
ER -
TY - JOUR
T1 - Mortalidad precoz en trasplante cardíaco
A1 - Juan Esteban Gómeza,∗, Noel Flóreza, Pastor Olayaa, Stephany Jaramillob, Julián Chicab, Martín Ramosa, Erika Rincóna y Diana Cristina Carrillo
Y1 - 2017///
KW - Cardiac transplant
KW - Mortality
KW - Trasplant
JF - Revista colombiana de cardiologia
VL - 24
IS - 5
SP - 442
EP - 447
N2 - Objetivo: describir las principales causas de mortalidad en los 30 primeros días postrasplante cardíaco. Métodos: cohorte retrospectiva de pacientes con trasplante cardiaco realizado de 2008 a 2015, que murieron en los primeros 30 días luego del procedimiento. La información se recolectó del registro institucional de trasplante cardíaco. Se describieron variables sociodemográficas, clínicas, características del receptor, causas de muerte, complicaciones y características del pre- intra- y postoperatorio. Resultados: desde enero de 2008 hasta agosto de 2015 se realizaron 74 trasplantes cardíacos. De estos, 10 pacientes murieron en los primeros 30 días postrasplante (mortalidad de 13,51%). La mediana de edad fue 55 a˜ nos (rango intercuartil [RIQ] 26-62 a˜ nos) y 50% de ellos fueron de sexo masculino. La mediana de fracción de eyección pretrasplante fue 24% (RIQ 18-47) y el tiempo en lista de espera 81 días (RIQ 12-157 días). Cuatro pacientes se encontraban en estadio 0 A y los seis restantes en estadio 1. La mediana de tiempo entre el trasplante y la muerte fue un día (RIQ 0-3 día) y la mortalidad más tardía se presentó a los 18 días. Las principales causas de muerte fueron: falla multiorgánica (5 casos), falla aguda del injerto (3 casos) y coagulopatía perioperatoria (2 casos). Conclusiones: en una institución de referencia para trasplante cardíaco del suroccidente colom- biano, la mortalidad precoz postrasplante cardíaco fue del 13,51%, similar a la reportada por registros internacionales. La principal causa de muerte fue la falla multiorgánica, que ocurrió principalmente en las primeras 24 horas después del trasplante cardíaco
ER -