Browsing by Author "Patarroyo, Manuel E."
Now showing items 1-11 of 11
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3D Analysis of the TCR/pMHCII Complex Formation in Monkeys Vaccinated with the First Peptide Inducing Sterilizing Immunity against Human Malaria
T-cell receptor gene rearrangements were studied in Aotus monkeys developing high antibody titers and sterilizing immunity against the Plasmodium falciparum malaria parasite upon vaccination with the modified synthetic ...
Artículo. 2010
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Characterising a microsatellite for DRB typing in Aotus vociferans and Aotus nancymaae (Platyrrhini)
Non-human primates belonging to the Aotus genus have been shown to be excellent experimental models for evaluating drugs and vaccine candidates against malaria and other human diseases. The immune system of this animal ... Artículo. 2014
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Computational prediction and experimental assessment of secreted/surface proteins from Mycobacterium tuberculosis H37Rv
The mycobacterial cell envelope has been implicated in the pathogenicity of tuberculosis and therefore has been a prime target for the identification and characterization of surface proteins with potential application in ... Artículo. 2010
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Human papillomavirus detection from human immunodeficiency virus-infected colombian women's paired urine and cervical samples
Infection, coinfection and type-specific human papillomavirus (HPV) distribution was evaluated in human immunodeficiency virus (HIV)-positive women from paired cervical and urine samples. Paired cervical and urine samples ... Artículo. 2013
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Identification of plasmodium vivax proteins with potential role in invasion using sequence redundancy reduction and profile hidden markov models
Background: This study describes a bioinformatics approach designed to identify Plasmodium vivax proteins potentially involved in reticulocyte invasion. Specifically, different protein training sets were built and tuned ... Artículo. 2011
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Identification, characterization and antigenicity of the Plasmodium vivax rhoptry neck protein 1 (PvRON1)
Background: Plasmodium vivax malaria remains a major health problem in tropical and sub-tropical regions worldwide. Several rhoptry proteins which are important for interaction with and/or invasion of red blood cells, such ... Artículo. 2011
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Immune protection-inducing protein structures (IMPIPS) against malaria : The weapons needed for beating Odysseus
The review covers the functional and structural approach followed by our group for more than 34 years in the search for a methodology that allows the rational design of chemically synthesised vaccines. An analogy between ... Artículo. 2015
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Micro-epidemiology of mixed-species malaria infections in a rural population living in the Colombian Amazon region
Malaria outbreaks have been reported in recent years in the Colombian Amazon region, malaria has been re-emerging in areas where it was previously controlled. Information from malaria transmission networks and knowledge ... Artículo. 2018
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Molecular modeling and in silico characterization of Mycobacterium tuberculosis TlyA : Possible misannotation of this tubercle bacilli-hemolysin
Background: The TlyA protein has a controversial function as a virulence factor in Mycobacterium tuberculosis (M. tuberculosis). At present, its dual activity as hemolysin and RNA methyltransferase in M. tuberculosis has ... Artículo. 2011
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Specific β-Turns Precede PPIIL Structures Binding to Allele-Specific HLA-DRβ1 ∗ PBRs in Fully-Protective Malaria Vaccine Components
The 3D structural analysis of 62 peptides derived from highly pathogenic Plasmodium falciparum malaria parasite proteins involved in host cell invasion led to finding a striking association between particular β-turn types ... Artículo. 2018
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Using the PfEMP1 Head Structure Binding Motif to Deal a Blow at Severe Malaria
Plasmodium falciparum (Pf) malaria causes 200 million cases worldwide, 8 million being severe and complicated leading to similar to 1 million deaths and similar to 100,000 abortions annually. Plasmodium falciparum erythrocyte ... Artículo. 2014
