Browsing by Author "Anaya, Juan-Manuel"
Now showing items 1-20 of 420
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16/6-idiotype expressing antibodies induce brain inflammation and cognitive impairment in mice: the mosaic of central nervous system involvement in lupus
Shaye, Kivity; Katzav, Aviva; Arango, María-Teresa; Landau-Rabi, Moran; Zafrir, Yaron; Agmon-Levin, Nancy; Blank, Miri; Anaya, Juan-Manuel; Mozes, Edna; Chapman, Joab; Shoenfeld, YehudaBackground: The 16/6-idiotype (16/6-Id) of the human anti-DNA antibody was found to induce experimental lupus in naive mice, manifested by production of autoantibodies, leukopenia and elevated inflammatory markers, as well ...Artículo. 2013
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A comprehensive analysis and immunobiology of autoimmune neurological syndromes during the Zika virus outbreak in Cúcuta, Colombia
Anaya, Juan-Manuel; Rodríguez, Yhojan; Monsalve-Carmona, Diana; Vega, Daniel; Ojeda, Ernesto; Gonzalez-Bravo, Diana; Rodríguez-Jímenez, Mónica; Pinto-Díaz, Carlos A.; Chaparro, Pablo; Gunturiz, María L.; Ansari, Aftab A.; Gershwin, M. Eric; Molano-González, Nicolas; Ramirez-Santana, Carolina; Acosta-Ampudia, YenyWe have focused on the epidemiology and immunobiology of Zika virus (ZIKV) infection and factors associated with the development of Guillain-Barré syndrome (GBS) and other neurological syndromes in Cúcuta, the capital of ...Artículo. 2017
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A functional haplotype of UBE2L3 confers risk for systemic lupus erythematosus
Wang, S; Adrianto, I; Wiley, G B; Lessard, C J; Kelly, J A; Adler, A J; Glenn, S B; Williams, A H; Ziegler, J T; Comeau, M E; Marion, M C; Wakeland, B E; Liang, C; Kaufman, K M; Guthridge, J M; Alarcón-Riquelme, M E; Alarcón, G S; Anaya, Juan-Manuel; Bae, S-C; Kim, J-H; Joo, Y B; Boackle, S A; Brown, E E; Petri, M A; Ramsey-Goldman, R; Reveille, J D; Vilá, L M; Criswell, L A; Edberg, J C; Freedman, B I; Gilkeson, G S; Jacob, C O; James, J A; Kamen, D L; Kimberly, R P; Martin, J; Merrill, J T; Niewold, T B; Pons-Estel, B A; Scofield, R H; Stevens, A M; Tsao, B P; Vyse, T J; Langefeld, C D; Harley, J B; Wakeland, E K; Moser, K L; Montgomery, C G; Gaffney, P MSystemic lupus erythematosus (SLE) is an autoimmune disease with diverse clinical manifestations characterized by the development of pathogenic autoantibodies manifesting in inflammation of target organs such as the kidneys, ...Artículo. 2012
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A latitudinal gradient study of common anti-infectious agent antibody prevalence in Italy and Colombia
Pordeus V.; Barzilai O.; Sherer Y.; Luiz R.R.; Blank M.; Bizzaro N.; Villalta D.; Anaya, Juan-Manuel; Shoenfeld Y.Background: Infectious agents are important in the pathogenesis of autoimmune disease since they are a major part of the environmental trigger of autoimmunity. A negative relationship between latitude and infectious disease ...Artículo. 2008
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A plausibly causal functional lupus-associated risk variant in the STAT1-STAT4 locus
Patel, Zubin H; Lu, Xiaoming; Miller, Daniel; Forney, Carmy R; Lee, Joshua; Lynch, Arthur; Schroeder, Connor; Parks, Lois; Magnusen, Albert F; Chen, Xiaoting; Pujato, Mario; Maddox, Avery; Zoller, Erin E; Namjou, Bahram; Brunner, Hermine I; Henrickson, Michael; Huggins, Jennifer L; Williams, Adrienne H; Ziegler, Julie T; Comeau, Mary E; Marion, Miranda C; Glenn, Stuart B; Adler, Adam; Shen, Nan; Nath, Swapan K; Stevens, Anne M; Freedman, Barry I; Pons-Estel, Bernardo A; Tsao, Betty P; Jacob, Chaim O; Kamen, Diane L; Brown, Elizabeth E; Gilkeson, Gary S; Alarcón, Graciela S; Martin, Javier; Reveille, John D; Anaya, Juan-Manuel; James, Judith A; Sivils, Kathy L; Criswell, Lindsey A; Vilá, Luis M; Petri, Michelle; Scofield, R Hal; Kimberly, Robert P; Edberg, Jeffrey C; Ramsey-Goldman, Rosalind; Bang, So-Young; Lee, Hye-Soon; Bae, Sang-Cheol; Boackle, Susan A; Graham, Deborah Cunninghame; Vyse, Timothy J; Merrill, Joan T; Niewold, Timothy B; Ainsworth, Hannah C; Silverman, Earl D; Weisman, Michael H; Wallace, Daniel J; Raj, Prithvi; Guthridge, Joel M; Gaffney, Patrick M; Kelly, Jennifer A; Alarcón-Riquelme, Marta E; Langefeld, Carl D; Wakeland, Edward K; Kaufman, Kenneth M; Weirauch, Matthew T; Harley, John B; Kottyan, Leah CSystemic lupus erythematosus (SLE or lupus) (OMIM: 152700) is a chronic autoimmune disease with debilitating inflammation that affects multiple organ systems. The STAT1-STAT4 locus is one of the first and most highly ...Artículo. 2018
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A polymorphism in the inducible nitric oxide synthase gene is associated with tuberculosis
Gómez, Luis Miguel; Anaya, Juan-Manuel; Vilchez, José Ramón; Cadena, Jose; Hinojosa, Rosa; Vélez, Luciano; Lopez-Nevot, Miguel Angel; Martín, JavieriNOS or NOS2 is a molecule that plays a key role in the immunological control of a broad spectrum of infectious agents. Investigation is hampered by difficulty in estimating in vivo production of nitric oxide (NO), but ...Artículo. 2007
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AB0403 Cigarette smoking and coffee consumption independently influence the risk of developing cardiovascular disease in systemic lupus erythematosus
Amaya-Amaya, J.; Pérez-Fernández, J. L.; Molano-González, Nicolas; Mantilla, R. D.; Rojas-Villarraga, A.; Anaya, Juan-ManuelBackground Cardiovascular disease (CVD) is a major cause of morbidity and mortality in patients with systemic lupus erythematosus (SLE), a 50-fold than general population. Traditional risk factors, such as, cigarette smoking ...Documento de conferencia. 2013
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AB0405 Factors associated with lupus nephritis in a highly admixed population
Pérez-Fernández, J. L.; Amaya-Amaya, J.; Molano-González, Nicolas; Mantilla, R.-D.; Rojas-Villarraga, A.; Anaya, Juan-ManuelBackground Lupus nephritis (LN) is one of the most serious complications of systemic lupus erythematous (SLE). Multiple clinical and serological risk and protective factors for LN have been identified in Caucasians.Documento de conferencia. 2013
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AB0421 Cutaneous involvement in systemic lupus erythematosus.a latenttraitanalysis
Molano-González, Nicolas; Pérez-Fernández, J. L.; Amaya-Amaya, J.; Mantilla, R. D.; Rojas-Villarraga, A.; Anaya, Juan-ManuelBackground Cutaneous involvement is one of the most frequent manifestations of systemic lupus erythematosus (SLE); however ethnicity may influence its prevalence and clinical expression.Documento de conferencia. 2013
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ABIN1 dysfunction as a genetic basis for lupus nephritis
Caster, Dawn J.; Korte, Erik A.; Nanda, Sambit K.; McLeish, Kenneth R.; Oliver, Rebecca K.; G'Sell, Rachel T.; Sheehan, Ryan M.; Freeman, Darrell W.; Coventry, Susan C.; Kelly, Jennifer A.; Guthridge, Joel M.; James, Judith A.; Sivils, Kathy L.; Alarcon-Riquelme, Marta E.; Scofield, R. Hal; Adrianto, Indra; Gaffney, Patrick M.; Stevens, Anne M.; Freedman, Barry I.; Langefeld, Carl D.; Tsao, Betty P.; Pons-Estel, Bernardo A.; Jacob, Chaim O.; Kamen, Diane L.; Gilkeson, Gary S.; Brown, Elizabeth E.; Alarcon, Graciela S.; Edberg, Jeffrey C.; Kimberly, Robert P.; Martin, Javier; Merrill, Joan T.; Harley, John B.; Kaufman, Kenneth M.; Reveille, John D.; Anaya, Juan-Manuel; Criswell, Lindsey A.; Vila, Luis M.; Petri, Michelle; Ramsey-Goldman, Rosalind; Bae, Sang-Cheol; Boackle, Susan A.; Vyse, Timothy J.; Niewold, Timothy B.; Cohen, Philip; Powell, David W.The genetic factors underlying the pathogenesis of lupus nephritis associated with systemic lupus erythematosus are largely unknown, although animal studies indicate that nuclear factor (NF)-?B is involved. We reported ...Artículo. 2013
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Abnormality of Oct-1 DNA binding in T cells from Sjogren's syndrome patients
Flescher, Eliezer; Vela Roch, Norma; Ogawa, Noriyoshi; Nakabayashi, Toru; Escalante, Agustin; Anaya, Juan-ManuelPrimary Sjögren's syndrome (SS) is an autoimmune rheumatic disease characterized by T cell hypoactivity. To understand the diminished T cell response to activation signals, we measured nucleoprotein DNA?binding activities ...Artículo. 1996
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Absence of a distinctive autoantibody profile in black women with lupus nephritis: comment on the article by McCarty et al
Joseph, Jasmine; Anaya, Juan-Manuel; Sandifer, Michele; Scopelitis, Eve; Wilson, Wendell; Espinoza, Luis R.McCarty and coworkers have pointed out a distinc- tive serologic profile in black women with lupus nephritis (1). We have reviewed the autoantibody profile in 42 of our black patients with systemic lupus erythematosus ...Artículo. 1994
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Accelerated nodulosis and systemic manifestations during methotrexate therapy for rheumatoid arthritis
Anaya, Juan-Manuel; Sany, J.; Combe, B; Didry, C; Gutiérrez-Peláez, MiguelObjectives: Methotrexate is successfully used in the treatment of arthritis but little is known about its effects on extra-articular manifestations of rheumatoid arthritis. We focused this work on the incidence and clinical ...Artículo. 1993
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Acceso a la atención en salud: En busca de la medicina personalizada y el sistema P5
Anaya, Juan-ManuelUna proporción significativa de las personas con necesidades de atención médica no recurren a los servicios de salud, encuentran barreras en el uso de esos servicios, y afirman que su problema no se resuelve, lo que indica ...Artículo. 2014
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Afecciones Autoinmunes endocrinas
Rojas M., William; Anaya, Juan-ManuelEn individuos genéticamente predispuestos, se han descrito afecciones autoinmunes en todas las glándulas endocrinas. En algunas enfermedades priman las reacciones citotóxicas, en tanto que en otras la ?siopatología se basa ...Parte de libro. 2015
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An antibody profile of systemic lupus erythematosus detected by antigen microarray
Fattal, Ittai; Shental, Noam; Mevorach, Dror; Anaya, Juan-Manuel; Livneh, Avi; Langevitz, Pnina; Zandman?Goddard, Gisele; Pauzner, Rachel; Lerner, Miriam; Blank, Miri; Hincapie, Maria?Eugenia; Gafter, Uzi; Naparstek, Yaakov; Shoenfeld, Yehuda; Domany, Eytan; Cohen, Irun R.Patients with systemic lupus erythematosus (SLE) produce antibodies to many different self-antigens. Here, we investigated antibodies in SLE sera using an antigen microarray containing many hundreds of antigens, mostly ...Artículo. 2010
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Analysis of DC-SIGN (CD209) Functional Variants in Patients with Tuberculosis
Gómez L.M.; Anaya, Juan-Manuel; Sierra-Filardi E.; Cadena J.; Corbí Á.; Martín J.Several lines of evidence suggest that host genetic factors controlling the immune response influence infection by Mycobacterium tuberculosis. Recently, DC-SIGN has been shown to be the major M. tuberculosis receptor on ...Artículo. 2006
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Analysis of IL1B, TAP1, TAP2 and IKBL polymorphisms on susceptibility to tuberculosis
Gomez L.M.; Camargo J.F.; Castiblanco J.; Ruiz-Narváez E.A.; Cadena J.; Anaya, Juan-ManuelGenetic determinants of human susceptibility to tuberculosis (TB) have not been completely elucidated. Interleukin-1 beta (IL-1?) and the inhibitor of kB-like (IkBL) are important molecules that participate in the inflammatory ...Artículo. 2006
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Anti-alpha-actinin antibodies are part of the anti-cell membrane antibody spectrum that characterize patients with lupus nephritis
Seret, Guillaume; Cañas, Felipe; Costanzo, Laurence Pougnet-Di; Hanrotel-Saliou, Catherine; Jousse-Joulin, Sandrine; Le Meur, Yannick; Saraux, Alain; Valeri, Antoine; Putterman, Chaim; Youinou, Pierre; Rojas-Villarraga, Adriana; Anaya, Juan-Manuel; Renaudineau, YvesAnti-membrane autoantibodies (MbA) have been reported in sera from patients with lupus nephritis (LN) but the targets of the MbA remain to be explored, which is the aim of the current study. Sera were collected from 40 ...Artículo. 2015
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Anti-CCP antibodies are associated with early age at onset in patients with rheumatoid arthritis
Diaz F.J.; Rojas-Villarraga A.; Salazar J.C.; Iglesias-Gamarra A.; Mantilla R.D.; Anaya, Juan-ManuelObjectives: To determine factors influencing the age at onset of rheumatoid arthritis (RA). Methods: A sample of 152 Colombian patients was investigated. Hazard ratios (HRs) that measured the effect size of risk factors ...Artículo. 2011