Now showing items 1-2 of 2

    • Inefficient DNA repair is an aging-related modifier of parkinson's disease 

      Sepe, Sara; Milanese, Chiara; Gabriels, Sylvia; Derks, Kasper W.J.; Payan-Gomez, Cesar; van IJcken, Wilfred F.J.; Rijksen, Yvonne M.A.; Nigg, Alex L.; Moreno, Sandra; Cerri, Silvia; Blandini, Fabio; Hoeijmakers, Jan H.J.; Mastroberardino, Pier G.
      The underlying relation between Parkinson's disease (PD) etiopathology and its major risk factor, aging, is largely unknown. In light of the causative link between genome stability and aging, we investigate a possible nexus ...
       Artículo. 2016
    • Preoperative fasting protects against renal ischemia-reperfusion injury in aged and overweight mice 

      Jongbloed, Franny; de Bruin, Ron W. F.; Pennings, Jeroen L. A.; Payán-Gómez, César; Engel, Sandra van den; Oostrom, Conny T. van; de Bruin, Alain; Hoeijmakers, Jan H. J.; Steeg, Harry van; IJzermans, Jan N. M.; Dollé, Martijn E. T.
      Ischemia-reperfusion injury (IRI) is inevitable during kidney transplantation leading to oxidative stress and inflammation. We previously reported that preoperative fasting in young-lean male mice protects against IRI. ...
       Artículo. 2014