Browsing by Author "Vanegas, Magnolia"
Now showing items 1-10 of 10
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Atomic evidence that modification of H-bonds established with amino acids critical for host-cell binding induces sterile immunity against malaria
"Based on the 3D X-ray crystallographic structures of relevant proteins of the malaria parasite involved in invasion to host cells and 3D NMR structures of High Activity Binding Peptides (HABPs) and their respective ...
Artículo. 2010
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Computational prediction and experimental assessment of secreted/surface proteins from Mycobacterium tuberculosis H37Rv
The mycobacterial cell envelope has been implicated in the pathogenicity of tuberculosis and therefore has been a prime target for the identification and characterization of surface proteins with potential application in ... Artículo. 2010
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Diagnostic accuracy of combinations of serological biomarkers for identifying clinical tuberculosis
Introduction: Confirmation of tuberculosis (TB) cases in endemic TB settings is a challenge; obtaining fast and cheap, though accurate, diagnostic tools such as biomarkers is thus urgently needed to enable the early detection ... Artículo. 2018
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Immunologic evaluation and validation of methods using synthetic peptides derived from Mycobacterium tuberculosis for the diagnosis of tuberculosis infection
The goal of this study was to demonstrate the usefulness of an enzyme-linked immunosorbent assay (ELISA) for the serodiagnosis of pulmonary tuberculosis (PTB) and extrapulmonary TB (EPTB). This assay used 20 amino acid-long, ... Artículo. 2013
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IMPIPS : The Immune Protection-Inducing Protein Structure concept in the search for steric-electron and topochemical principles for complete fully-protective chemically synthesised vaccine development
Determining immune protection-inducing protein structures (IMPIPS) involves defining the stereo-electron and topochemical characteristics which are essential in MHC-p-TCR complex formation. Modified high activity binding ... Artículo. 2015
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Problemas y logros en la lucha contra la trata de personas en Colombia
La trata de personas es un delito que ha tomado fuerza fuerza en los últimos alis alrdedor del mundo. Las diferentes víctimas son sometidas a toda clase de flagelos como lo son la explotación laboral, el trabajo forzoso y ... Documento de trabajo. 2011
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Protecting capacity against malaria of chemically defined tetramer forms based on the Plasmodium falciparum apical sushi protein as potential vaccine components
"Developing novel generations of subunit-based antimalarial vaccines in the form of chemically-defined macromolecule systems for multiple antigen presentation represents a classical problem in the field of vaccine development. ... Artículo. 2014
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Specific β-Turns Precede PPIIL Structures Binding to Allele-Specific HLA-DRβ1 ∗ PBRs in Fully-Protective Malaria Vaccine Components
The 3D structural analysis of 62 peptides derived from highly pathogenic Plasmodium falciparum malaria parasite proteins involved in host cell invasion led to finding a striking association between particular β-turn types ... Artículo. 2018
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Towards designing a synthetic antituberculosis vaccine : The Rv3587c peptide inhibits mycobacterial entry to host cells
Mycobacterium tuberculosis is considered one of the most successful pathogens in the history of mankind, having caused 1.7 million deaths in 2016. The amount of resistant and extensively resistant strains has increased; ... Artículo. 2018
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Using the PfEMP1 Head Structure Binding Motif to Deal a Blow at Severe Malaria
Plasmodium falciparum (Pf) malaria causes 200 million cases worldwide, 8 million being severe and complicated leading to similar to 1 million deaths and similar to 100,000 abortions annually. Plasmodium falciparum erythrocyte ... Artículo. 2014
