Now showing items 1-11 of 11

    • A Precise Computational Measure of Impulsivity that Signals Relevant Outcomes in Opioid Addiction Treatment 

      López Guzmán, Silvia
      Computational models of impulsive decision-making, like temporal discounting, are widely used to study addiction. However, clinically validating a marker supposes developing methods that provide high accuracy and reliability. ...
       parte de Libro. 2017
    • Computational Markers of Risky Decision-making for Identification of Temporal Windows of Vulnerability to Opioid Use in a Real-world Clinical Setting 

      Konova, Anna B.; López Guzmán, Silvia; Urmanche, Adelya; Ross, Stephen; Louie, Kenway; Rotrosen, John; Glimcher, Paul W.
      "Importance: Opioid addiction is a major public health problem. Despite availability of evidence-based treatments, relapse and dropout are common outcomes. Efforts aimed at identifying reuse risk and gaining more precise ...
       Artículo. 2020
    • Computational psychiatry of impulsivity and risk: how risk and time preferences interact in health and disease 

      López Guzmán, Silvia; Konova, Anna B.; Glimcher, Paul W.
      "Choice impulsivity is an important subcomponent of the broader construct of impulsivity and is a key feature of many psychiatric disorders. Choice impulsivity is typically quantified as temporal discounting, a well-documented ...
       Artículo. 2019
    • Distamycin A inhibits HMGA1-binding to the P-selectin promoter and attenuates lung and liver inflammation during murine endotoxemia 

      Baron, Rebecca M.; López Guzmán, Silvia; Riascos, Dario F.; Macias, Alvaro A.; Layne, Matthew D.; Cheng, Guiying; Harris, Cailin; Chung, Su Wol; Reeves, Raymond; von Andrian, Ulrich H.; Perrella, Mark A.
      Background The architectural transcription factor High Mobility Group-A1 (HMGA1) binds to the minor groove of AT-rich DNA and forms transcription factor complexes (“enhanceosomes”) that upregulate expression of select genes ...
       Artículo. 2010
    • Frontline Science: Targeted expression of a dominant-negative high mobility group A1 transgene improves outcome in sepsis 

      Baron, Rebecca M.; Kwon, Min?Young; Castano, Ana P.; Ghanta, Sailaja; Riascos?Bernal, Dario F.; López Guzmán, Silvia; Macias, Alvaro Andres; Ith, Bonna; Schissel, Scott L.; Lederer, James A.; Reeves, Raymond; Yet, Shaw?Fang; Layne, Matthew D.; Xiaoli, Liu; Perrella, Mark A.
      High mobility group (HMG) proteins are a family of architectural transcription factors, with HMGA1 playing a role in the regulation of genes involved in promoting systemic inflammatory responses. We speculated that blocking ...
       Artículo. 2018
    • Interaction between stress and addiction: Contributions from Latin-American neuroscience 

      Torres-Berrio, Angélica; Cuesta, Santiago; López Guzmán, Silvia; Nava-Mesa, Mauricio O.
      "Drug addiction is a chronic neuropsychiatric disorder that escalates from an initial exposure to drugs of abuse, such as cocaine, cannabis, or heroin, to compulsive drug-seeking and intake, reduced ability to inhibit ...
       Artículo. 2018
    • Polyautoimmunity and familial autoimmunity in systemic sclerosis 

      Hudson, Marie; Rojas-Villarraga, Adriana; Coral-Alvarado, Paola; López Guzmán, Silvia; Mantilla, Ruben D.; Chalem, Philippe; Group, Canadian Scleroderma Research; Group, Colombian Scleroderma Research; Baron, Murray; Anaya, Juan-Manuel
      "Characterization of the extent to which particular combinations of autoimmune diseases occur in excess of that expected by chance may offer new insights into possible common pathophysiological mechanisms. The goal of this ...
       Artículo. 2008

      ORTEGA-HERNÁNDEZ, OSCAR DANILO; López Guzmán, Silvia; Rojas-Villarraga, Adriana; ANAYA, JUAN-MANUEL
      Las enfermedades autoinmunes comprenden un conjunto de desórdenes crónicos multisistémicos y complejos de etiología desconocida, asociados a factores genéticos, hormonales y ambientales. La susceptibilidad a padecerlas ...
       Artículo. 2008
    • Risk Factors Associated with Different Stages of Atherosclerosis in Colombian Patients with Rheumatoid Arthritis 

      Rojas-Villarraga, Adriana; Ortega-Hernandez, Oscar-Danilo; Gomez, Luis F.; Pardo, Aryce L.; López Guzmán, Silvia; Arango-Ferreira, Camila; Hincapie, Maria-Eugenia; Betancur, Juan F.; Pineda-Tamayo, Ricardo; Diaz, Francisco J.; Anaya, Juan-Manuel
      Rheumatoid arthritis (RA) is associated with an increased prevalence of cardiovascular disease (CVD). Since atherosclerosis development is a gradual process of damage inside the artery wall, and the phenotype–genotype ...
       Artículo. 2008
    • Risk preferences impose a hidden distortion on measures of choice impulsivity 

      López Guzmán, Silvia; Konova, Anna B.; Louie, Kenway; Glimcher, Paul W.
      Measuring temporal discounting through the use of intertemporal choice tasks is now the gold standard method for quantifying human choice impulsivity (impatience) in neuroscience, psychology, behavioral economics, public ...
       Artículo. 2018
    • Tinitus: avances en fisiopatología y tratamiento 

      Páez Nova, Maximiliana; Caicedo, Ernesto Esteban; Espinosa, Jairo Alberto; Ladino Malagón, Diana; López Guzmán, Silvia; González González, Camilo
      "El tinitus y las alucinaciones auditivas son sensaciones de percepción de sonido en ausencia de sonido externo, afectan al 15% de la población, y puede ser completamente incapacitante para los pacientes. Se han identificado ...
       Artículo. 2006