Now showing items 1-20 of 23

    • 22q11.2 DS syndrome as a genetic subtype of schizophrenia 

      Huertas-Rodríguez, Cindy Katherin; Payan-Gomez, Cesar; Forero-Castro, Ruth Maribel
      Introduction The 22q11.2 deletion syndrome (22q11.2 DS) is associated with the microdeletion of this chromosomal region, and represents the second most common genetic syndrome after Down's syndrome. In patients with ...
       Artículo. 2015
    • A propósito de 5 casos de paraparesia espástica tropical en Puerto Tejada (Cauca) 

      Zaninovic, Vladimir; Moreno, Diego; Payan-Gomez, Cesar; Rodríguez, Adriana
      Debido a que durante los últimos años han llegado al Hospital Universitario del Valle(HUV), Cali, 5 pacientes de Puerto Tejada con paraparesia espástica tropical (PET)asociada con el virus linfotrópico humano de células T ...
       Artículo. 1997
    • BACH2: A marker of DNA damage and ageing 

      Uittenboogaard, L.M.; Payan-Gomez, Cesar; Pothof, J.; van IJcken, W.; Mastroberardino, P.G.; van der Pluijm, I.; Hoeijmakers, J.H.J.; Tresini, M.
      DNA damage and ageing share expression changes involving alterations in many aspects of metabolism, suppression of growth and upregulation of defence and genome maintenance systems. 'Omics' technologies have permitted ...
       Artículo. 2013
    • Bioenergetic and proteolytic defects in fibroblasts from patients with sporadic Parkinson's disease 

      Ambrosi, Giulia; Ghezzi, Cristina; Sepe, Sara; Milanese, Chiara; Payan-Gomez, Cesar; Bombardieri, Cintia R.; Armentero, Marie-Therese; Zangaglia, Roberta; Pacchett, Claudio; Mastroberardino, Pier Giorgio; Blandini, Fabio
      Background: Parkinson's disease (PD) is a complex disease and the current interest and focus of scientific research is both investigating the variety of causes that underlie PD pathogenesis, and identifying reliable ...
       Artículo. 2014
    • Brief history of bioinformatics 

      Franco M.L.; Cediel-Becerra, Juan-Fernado; Payan-Gomez, Cesar
      Bioinformatics appears as the result of the indissoluble marriage between informatics technology and life sciences. Although it was conceived in principle to resolve questions such as the following: How to store and organize ...
       Artículo. 2008
    • Christiaan Barnard: 40 años del primer transplante de corazón humano 

      Reynolds, Jorge; Cediel-Becerra, Juan-Fernado; Payan-Gomez, Cesar
      «El sábado, yo era un cirujano en Sudáfrica, poco conocido. El lunes, yo era una celebridad mundial» Fueron éstas las palabras pronunciadas por Christiaan Neethling Barnard para referirse al domingo 3 de diciembre de 1967 ...
       Artículo. 2007
    • Co-Expression Network Analysis Identifies Possible Hub Genes in Aging of the Human Prefrontal Cortex 

      Payan-Gomez, Cesar; Riaño-Moreno, MD, MSc, Julián; Amador-Munoz, Diana Patricia; Ramírez-Clavijo, Sandra
      Introducción: el envejecimiento es el principal factor de riesgo para el desarrollo de enfermedades crónicas como el cáncer, la diabetes, el Parkinson y el Alzheimer. El sistema nervioso central es particularmente susceptible ...
       Artículo. 2019
    • Cysteine oxidation and redox signaling in dopaminergic neurons physiology and in Parkinson's disease 

      Milanese, Chiara; Payan-Gomez, Cesar; Mastroberardino, Pier G
      Parkinson's disease (PD)is a neurological disorder affecting dopaminergic neurons in the nigrostriatal pathways of the brain. PD is a multifactorial disease and its causes should be sought in detrimental interactions between ...
       Artículo. 2019
    • Differences and homologies of chromosomal alterations within and between breast cancer cell lines : A clustering analysis 

      Rondón-Lagos, Milena; Verdun Di Cantogno, Ludovica; Marchió, Caterina; Rangel, Nelson; Payan-Gomez, Cesar; Gugliotta, Patrizia; Botta, Cristina; Bussolati, Gianni; Ramírez-Clavijo, Sandra; Pasini, Barbara; Sapino, Anna
      Background: The MCF7 (ER+/HER2-), T47D (ER+/HER2-), BT474 (ER+/HER2+) and SKBR3 (ER-/HER2+) breast cancer cell lines are widely used in breast cancer research as paradigms of the luminal and HER2 phenotypes. Although they ...
       Artículo. 2014
    • DNA damage and transcription stress cause ATP-mediated redesign of metabolism and potentiation of anti-oxidant buffering 

      Milanese, Chiara; Bombardieri, Cíntia R.; Sepe, Sara; Barnhoorn, Sander; Payan-Gomez, Cesar; Caruso, Donatella; Audano, Matteo; Pedretti, Silvia; Vermeij, Wilbert P.; Brandt, Renata M. C.; Gyenis, Akos; Wamelink, Mirjam M.; de Wit, Annelieke S.; Janssens, Roel C.; Leen, René; van Kuilenburg, André B. P.; Mitro, Nico; Hoeijmakers, Jan H. J.; Mastroberardino, Pier G.
      Accumulation of DNA lesions causing transcription stress is associated with natural and accelerated aging and culminates with profound metabolic alterations. Our understanding of the mechanisms governing metabolic redesign ...
       Artículo. 2019
    • Ebstein anomaly associated with cri du chat (cat's cry) syndrome and 20q duplication 

      Olivella, Alberto; Manotas, Hernan; Payan-Gomez, Cesar; Piñeros, Juan Gabriel
      Ebstein anomaly is a congenital heart defect with a low prevalence and high mortality in the early stages of life. In medical literature, there is no reported association between Ebstein anomaly and cri du chat syndrome. ...
       Artículo. 2020
    • Enfermedad de Creutzfeldt-Jakob esporádica: estudio clínico, patológico y molecular de un caso 

      Villegas, Victoria E.; Velandia-Hurtado, Fernando; Payan-Gomez, Cesar
      Generalidades. Las encefalopatías espongiformes transmisibles son enfermedades neurodegenerativas ocasionadas por la acumulación anormal de una variante mal plegada de la proteína priónica, lo cual induce la formación de ...
       Artículo. 2010
    • Expresión de TRF2 y GAPDH en el envejecimiento de las células del epitelio superficial del ovario in vitro 

      Chuaire-Noack, Lilian; Monterrey, Pedro; Payan-Gomez, Cesar
      Se ha demostrado que la proteína GAPDH se puede unir al ADN telomérico de cadena sencilla, tanto in vitro como in vivo. Por lo tanto, se ha planteado la hipótesis de que la GAPDH juega un papel importante en la protección ...
       Artículo. 2011
    • Fragile X syndrome and connective tissue dysregulation 

      Ramírez-Cheyne J.A.; Duque G.A.; Ayala-Zapata S.; Saldarriaga-Gil W.; Hagerman P.; Hagerman R.; Payan-Gomez, Cesar
      Fragile X syndrome (FXS) is the most common cause of inherited intellectual disabilities and autism spectrum disorders, and it is an X-linked disorder in which there is a deficiency of the fragile X mental retardation 1 ...
       Artículo. 2019
    • Identification of transcriptomic responses related to normal, healthy and accelerated aging 

      Payan-Gomez, Cesar
      El envejecimiento es la reducción de las capacidades fisiológicas y adaptativas del organismo con el paso del tiempo. La acumulación de daño en el ADN podría ser el evento central desencadenante del proceso de envejecimiento. ...
       Tesis de doctorado. 2018
    • Immunohistochemical and molecular profiling of histologically defined apocrine carcinomas of the breast 

      Vranic, Semir; Marchiò, Caterina; Castellano, Isabella; Botta, Cristina; Scalzo, Maria Stella; Bender, Ryan P.; Payan-Gomez, Cesar; di Cantogno, Ludovica Verdun; Gugliotta, Patrizia; Tondat, Fabrizio; di Celle, Paola Francia; Mariani, Sara; Gatalica, Zoran; Sapino, Anna
      Summary Despite the marked improvement in the understanding of molecular mechanisms and classification of apocrine carcinoma, little is known about its specific molecular genetic alterations and potentially targetable ...
       Documento de conferencia. 2015
    • Inefficient DNA repair is an aging-related modifier of parkinson's disease 

      Sepe, Sara; Milanese, Chiara; Gabriels, Sylvia; Derks, Kasper W.J.; Payan-Gomez, Cesar; van IJcken, Wilfred F.J.; Rijksen, Yvonne M.A.; Nigg, Alex L.; Moreno, Sandra; Cerri, Silvia; Blandini, Fabio; Hoeijmakers, Jan H.J.; Mastroberardino, Pier G.
      The underlying relation between Parkinson's disease (PD) etiopathology and its major risk factor, aging, is largely unknown. In light of the causative link between genome stability and aging, we investigate a possible nexus ...
       Artículo. 2016
    • Integrative analysis of global gene expression identifies opposite patterns of reactive astrogliosis in aged human prefrontal cortex 

      Payan-Gomez, Cesar; Rodríguez, Diego; Amador-Munoz, Diana Patricia; Ramírez-Clavijo, Sandra
      The prefrontal cortex (PFC) is one of the brain regions with more prominent changes in human aging. The molecular processes related to the cognitive decline and mood changes during aging are not completely understood. To ...
       Artículo. 2018
    • Nucleotide excision repair in chronic neurodegenerative diseases 

      Sepe, Sara; Payan-Gomez, Cesar; Milanese, Chiara; Hoeijmakers, Jan H.; Mastroberardino, Pier G.
      Impaired DNA repair involving the nucleotide excision repair (NER)/transcription-coupled repair (TCR) pathway cause human pathologies associated with severe neurological symptoms. These clinical observations suggest that ...
       Artículo. 2013
    • Peripheral mitochondrial function correlates with clinical severity in idiopathic Parkinson’s disease 

      Milanese, Chiara; Payan-Gomez, Cesar; Galvani, Marta; González, Nicolás Molano; Tresini, Maria; Abdellah, Soraya Nait; van Roon?Mom, Willeke M. C.; Figini, Silvia; Marinus, Johan; van Hilten, Jacobus J.; Mastroberardino, Pier G.
      Background: Parkinson’s disease is an intractable disorder with heterogeneous clinical presentation that may reflect different underlying pathogenic mechanisms. Surrogate indicators of pathogenic processes correlating with ...
       Artículo. 2019