Now showing items 1-6 of 6

    • Bioenergetic and proteolytic defects in fibroblasts from patients with sporadic Parkinson's disease 

      Ambrosi, Giulia; Ghezzi, Cristina; Sepe, Sara; Milanese, Chiara; Payan-Gomez, Cesar; Bombardieri, Cintia R.; Armentero, Marie-Therese; Zangaglia, Roberta; Pacchett, Claudio; Mastroberardino, Pier Giorgio; Blandini, Fabio
      Background: Parkinson's disease (PD) is a complex disease and the current interest and focus of scientific research is both investigating the variety of causes that underlie PD pathogenesis, and identifying reliable ...
       Artículo. 2014
    • Differences and homologies of chromosomal alterations within and between breast cancer cell lines : A clustering analysis 

      Rondón-Lagos, Milena; Verdun Di Cantogno, Ludovica; Marchió, Caterina; Rangel, Nelson; Payan-Gomez, Cesar; Gugliotta, Patrizia; Botta, Cristina; Bussolati, Gianni; Ramírez-Clavijo, Sandra; Pasini, Barbara; Sapino, Anna
      Background: The MCF7 (ER+/HER2-), T47D (ER+/HER2-), BT474 (ER+/HER2+) and SKBR3 (ER-/HER2+) breast cancer cell lines are widely used in breast cancer research as paradigms of the luminal and HER2 phenotypes. Although they ...
       Artículo. 2014
    • Identification of transcriptomic responses related to normal, healthy and accelerated aging 

      Payan-Gomez, Cesar
      El envejecimiento es la reducción de las capacidades fisiológicas y adaptativas del organismo con el paso del tiempo. La acumulación de daño en el ADN podría ser el evento central desencadenante del proceso de envejecimiento. ...
       Tesis de doctorado. 2018
    • Immunohistochemical and molecular profiling of histologically defined apocrine carcinomas of the breast 

      "Vranic, Semir; Marchiò, Caterina; Castellano, Isabella; Botta, Cristina; Scalzo, Maria Stella; Bender, Ryan P.; Payan-Gomez, Cesar; di Cantogno, Ludovica Verdun; Gugliotta, Patrizia; Tondat, Fabrizio; di Celle, Paola Francia; Mariani, Sara; Gatalica, Zoran; Sapino, Anna"
      "Summary Despite the marked improvement in the understanding of molecular mechanisms and classification of apocrine carcinoma, little is known about its specific molecular genetic alterations and potentially targetable ...
       Documento de conferencia. 2015
    • Inefficient DNA repair is an aging-related modifier of parkinson's disease 

      Sepe, Sara; Milanese, Chiara; Gabriels, Sylvia; Derks, Kasper W.J.; Payan-Gomez, Cesar; van IJcken, Wilfred F.J.; Rijksen, Yvonne M.A.; Nigg, Alex L.; Moreno, Sandra; Cerri, Silvia; Blandini, Fabio; Hoeijmakers, Jan H.J.; Mastroberardino, Pier G.
      The underlying relation between Parkinson's disease (PD) etiopathology and its major risk factor, aging, is largely unknown. In light of the causative link between genome stability and aging, we investigate a possible nexus ...
       Artículo. 2016
    • Nucleotide excision repair in chronic neurodegenerative diseases 

      "Sepe, Sara; Payan-Gomez, Cesar; Milanese, Chiara; Hoeijmakers, Jan H.; Mastroberardino, Pier G."
      "Impaired DNA repair involving the nucleotide excision repair (NER)/transcription-coupled repair (TCR) pathway cause human pathologies associated with severe neurological symptoms. These clinical observations suggest that ...
       Artículo. 2013