Browsing by Author "Patarroyo, Manuel A."
Now showing items 1-20 of 87
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3D Analysis of the TCR/pMHCII Complex Formation in Monkeys Vaccinated with the First Peptide Inducing Sterilizing Immunity against Human Malaria
T-cell receptor gene rearrangements were studied in Aotus monkeys developing high antibody titers and sterilizing immunity against the Plasmodium falciparum malaria parasite upon vaccination with the modified synthetic ...
Artículo. 2010
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A single amino acid change in the Plasmodium falciparum RH5 (PfRH5) human RBC binding sequence modifies its structure and determines species-specific binding activity
"Identifying the ligands or regions derived from them which parasites use to invade their target cells has proved to be an excellent strategy for identifying targets for vaccine development. Members of the reticulocyte-binding ... Artículo. 2012
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Annotation and characterization of the Plasmodium vivax rhoptry neck protein 4 (PvRON4)
Background: The tight junction (TJ) is one of the most important structures established during merozoite invasion of host cells and a large amount of proteins stored in Toxoplasma and Plasmodium parasites’ apical organelles ... Artículo. 2013
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"Binding activity, structure, and immunogenicity of synthetic peptides derived from Plasmodium falciparum CelTOS and TRSP proteins"
"Several sporozoite proteins have been associated with Plasmodium falciparum cell traversal and hepatocyte invasion, including the cell-traversal protein for ookinetes and sporozoites (CelTOS), and thrombospondin-related ... Artículo. 2012
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Characterising a microsatellite for DRB typing in Aotus vociferans and Aotus nancymaae (Platyrrhini)
Non-human primates belonging to the Aotus genus have been shown to be excellent experimental models for evaluating drugs and vaccine candidates against malaria and other human diseases. The immune system of this animal ... Artículo. 2014
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Characterising atypical Candida albicans clinical isolates from six third-level hospitals in Bogotá, Colombia
Background: Candida species are the most frequently found fungal pathogens causing nosocomial disease in a hospital setting. Such species must be correctly identified to ensure that appropriate control measures are taken ... Artículo. 2015
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Characterization of Plasmodium falciparum integral membrane protein Pf25-IMP and identification of its red blood cell binding sequences inhibiting merozoite invasion in vitro
"The identification of proteins present on the surface of Plasmodium falciparum-infected red blood cells as well as of free merozoites has been widely considered as one of the main areas of research in the development of ... Artículo. 2008
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Characterizing PvARP, a novel Plasmodium vivax antigen
Background Plasmodium vivax continues to be the most widely distributed malarial parasite species in tropical and sub-tropical areas, causing high morbidity indices around the world. Better understanding of the proteins ... Artículo. 2013
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Chlamydia trachomatis frequency in a cohort of HPV-infected colombian women
Background Chlamydia trachomatis (C. trachomatis), an obligate intracellular bacterium, is the commonest infectious bacterial agent of sexual transmission throughout the world. It has been shown that the presence of this ... Artículo. 2016
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Complement Receptor 1 availability on red blood cell surface modulates Plasmodium vivax invasion of human reticulocytes
"Plasmodium vivax parasites preferentially invade reticulocyte cells in a multistep process that is still poorly understood. In this study, we used ex vivo invasion assays and population genetic analyses to investigate the ... Artículo. 2019
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Computational prediction and experimental assessment of secreted/surface proteins from Mycobacterium tuberculosis H37Rv
The mycobacterial cell envelope has been implicated in the pathogenicity of tuberculosis and therefore has been a prime target for the identification and characterization of surface proteins with potential application in ... Artículo. 2010
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Conserved high activity binding peptides from the Plasmodium falciparum Pf34 rhoptry protein inhibit merozoites in vitro invasion of red blood cells
"Rhoptries are specialized secretory organelles found in all members of the genus Plasmodium whose proteins have been considered as promising vaccine candidates due to their involvement in cell invasion and the formation ... Artículo. 2010
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Conserved regions of the Plasmodium falciparum rhoptry-associated protein 3 mediate specific host-pathogen interactions during invasion of red blood cells
"Invasion of red blood cells (RBCs) by the Plasmodium falciparum malaria merozoite is mediated by parasite surface molecules and proteins contained within apical organelles that are capable of recognizing receptors on the ... Artículo. 2010
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Determining Clostridium difficile intra-taxa diversity by mining multilocus sequence typing databases
Background: Multilocus sequence typing (MLST) is a highly discriminatory typing strategy; it is reproducible and scalable. There is a MLST scheme for Clostridium difficile (CD), a gram positive bacillus causing different ... Artículo. 2017
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Diagnostic accuracy of combinations of serological biomarkers for identifying clinical tuberculosis
Introduction: Confirmation of tuberculosis (TB) cases in endemic TB settings is a challenge; obtaining fast and cheap, though accurate, diagnostic tools such as biomarkers is thus urgently needed to enable the early detection ... Artículo. 2018
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Distribution patterns of infection with multiple types of human papillomaviruses and their association with risk factors
Background: Infection with multiple types of human papillomavirus (HPV) is one of the main risk factors associated with the development of cervical lesions. In this study, cervical samples collected from 1,810 women with ... Artículo. 2011
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Easy and fast method for expression and native extraction of Plasmodium vivax Duffy binding protein fragments
Background: The Plasmodium vivax Duffy binding protein (PvDBP) has been the most studied ligand binding human reticulocytes to date. This molecule has a cysteine-rich domain in region II (RII) which has been used as control ... Artículo. 2018
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Enhanced virulence of Beauveria bassiana against Diatraea saccharalis using a soluble recombinant enzyme with endo- and exochitinase activity
"Beauveria bassiana chitinases are involved in degrading the chitin in insects’ exoskeletons and internal structures, and thus are important virulence factors as they participate in initial to final steps of infection. In ... Artículo. 2020
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Evaluating Sarconesiopsis magellanica blowfly-derived larval therapy and comparing it to Lucilia sericata-derived therapy in an animal model
"Larval therapy is used as alternative treatment for hard-to-heal chronic and infected wounds. Lucilia sericata is the most used blowfly species. However, it has been shown recently that Sarconesiopsis magellanica larval ... Artículo. 2016
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Evaluating the biological cycle and reproductive and population parameters of calliphora vicina (Diptera: Calliphoridae) reared on three different diets
"This work was aimed at evaluating Calliphora vicina Robineau-Desvoidy (Diptera: Calliphoridae) life cycle, life tables, and reproductive and population parameters. This species is a necrophagous, synanthropic, cosmopolitan ... Artículo. 2016
