Now showing items 1-3 of 3

    • Bioenergetic and proteolytic defects in fibroblasts from patients with sporadic Parkinson's disease 

      Ambrosi, Giulia; Ghezzi, Cristina; Sepe, Sara; Milanese, Chiara; Payan-Gomez, Cesar; Bombardieri, Cintia R.; Armentero, Marie-Therese; Zangaglia, Roberta; Pacchett, Claudio; Mastroberardino, Pier Giorgio; Blandini, Fabio
      Background: Parkinson's disease (PD) is a complex disease and the current interest and focus of scientific research is both investigating the variety of causes that underlie PD pathogenesis, and identifying reliable ...
       Artículo. 2014
    • DNA damage and transcription stress cause ATP-mediated redesign of metabolism and potentiation of anti-oxidant buffering 

      "Milanese, Chiara; Bombardieri, Cíntia R.; Sepe, Sara; Barnhoorn, Sander; Payán-Goméz, César; Caruso, Donatella; Audano, Matteo; Pedretti, Silvia; Vermeij, Wilbert P.; Brandt, Renata M. C.; Gyenis, Akos; Wamelink, Mirjam M.; de Wit, Annelieke S.; Janssens, Roel C.; Leen, René; van Kuilenburg, André B. P.; Mitro, Nico; Hoeijmakers, Jan H. J.; Mastroberardino, Pier G."
      "Accumulation of DNA lesions causing transcription stress is associated with natural and accelerated aging and culminates with profound metabolic alterations. Our understanding of the mechanisms governing metabolic redesign ...
       Artículo. 2019
    • Inefficient DNA repair is an aging-related modifier of parkinson's disease 

      Sepe, Sara; Milanese, Chiara; Gabriels, Sylvia; Derks, Kasper W.J.; Payan-Gomez, Cesar; van IJcken, Wilfred F.J.; Rijksen, Yvonne M.A.; Nigg, Alex L.; Moreno, Sandra; Cerri, Silvia; Blandini, Fabio; Hoeijmakers, Jan H.J.; Mastroberardino, Pier G.
      The underlying relation between Parkinson's disease (PD) etiopathology and its major risk factor, aging, is largely unknown. In light of the causative link between genome stability and aging, we investigate a possible nexus ...
       Artículo. 2016