Browsing by Author "Salazar, Luz Mary"
Now showing items 1-8 of 8
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Elongating modified conserved peptides eliminates their immunogenicity and protective efficacy against P. falciparum malaria
"Plasmodium falciparum malaria protein peptides were synthesised in the search for more effective routes for inducing a protective immune response against this deadly parasite and this information has been associated with ...
Artículo. 2005
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Evidence supporting the hypothesis that specifically modifying a malaria peptide to fit into HLA-DR?1 *03 molecules induces antibody production and protection
"La proteína EBA-175 se utiliza como ligando en la unión de Plasmodium falciparum a los eritrocitos. La evidencia muestra que el péptido 1815 conservado de esta proteína que tiene una alta capacidad de unión a los glóbulos ... Artículo. 2005
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High non-protective, long-lasting antibody levels in malaria are associated with haplotype shifting in MHC-peptide-TCR complex formation: a new mechanism for immune evasion
"An effective malarial vaccine must contain multiple immunogenic, protection-inducing epitopes able to block and destroy the P. falciparum malaria parasite, the most lethal form of this disease in the world. Our strategy ... Artículo. 2006
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HLA-DR allele reading register shifting is associated with immunity induced by SERA peptide analogues
SERA protein is a leading candidate molecule to be included in an antimalarial vaccine. Conserved high activity binding peptides (HABP) binding to red blood cells (RBC) have been identified in this protein. One of them ... Artículo. 2008
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Induction and displacement of an helix in the 6725 SERA peptide analogue confers protection against P. falciparum malaria.
"The protein called serine repeat antigen (SERA) is a Plasmodium falciparum malaria antigen; high activity erythrocyte binding peptides have been identified in this protein. One of these, the 6725 peptide (non-immunogenic ... Artículo. 2004
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Mapping the anatomy of a Plasmodium falciparum MSP-1 epitope using pseudopeptide-induced mono- and polyclonal antibodies and CD and NMR conformation analysis
"Antigen structure modulation represents an approach towards designing subunit malaria vaccines. A specific epitope's ? carbon stereochemistry, as well as its backbone topochemistry, was assessed for obtaining novel malarial ... Artículo. 2004
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Quantifying intracellular Mycobacterium tuberculosis : An essential issue for in vitro assays
Many studies about intracellular microorganisms which are important regarding diseases affecting public health have been focused on the recognition of host–pathogen interactions, thereby ascertaining the mechanisms by which ...
Revisión. 2018
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Serine Repeat Antigen Peptides which bind specifically to Red Blood Cells.
It has been reported that serine repeat antigen (SERA) binds directly to human erythrocyte membranes, inside-out vesicles and intact mouse erythrocytes. Similarly, mAbs specific against SERA are effective in blocking red ... Artículo. 2000
