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dc.contributor.advisorMeneses Echávez, José Francisco 
dc.creatorReyes, Alexander 
dc.date.accessioned2016-05-04T19:17:26Z
dc.date.available2016-05-04T19:17:26Z
dc.date.created2015-02-06
dc.date.issued2015 
dc.identifier.urihttp://repository.urosario.edu.co/handle/10336/11958
dc.descriptionAntecedentes. La enfermedad de Parkinson (EP) es la segunda enfermedad neurodegenerativa más común en el mundo, la cual afecta el componente físico, psicológico y social de los individuos que la padecen. Numerosos estudios han abordado los beneficios de diferentes programas de ejercicio, llegando a ser una estrategia no-farmacológica efectiva para aminorar el deterioro funcional de los pacientes con EP. Objetivo. Determinar los efectos de las diferentes modalidades de ejercicio físico en los principales desenlaces clínicos en pacientes con EP. Métodos. Se consultaron las bases de datos MEDLINE, EMBASE, Scopus, CENTRAL y PEDro desde febrero de 1990 hasta febrero de 2014 para identificar Ensayos Clínicos Aleatorizados (ECA) publicados. Además, se examinaron las listas de referencias de otras revisiones y de estudios identificados. La extracción de datos se realizó por dos autores independientes. Se empleó un modelo de efectos aleatorios en presencia de heterogeneidad estadística (I2>50%). El sesgo de publicación fue evaluado mediante el gráfico de embudo. Resultados: Un total de 18 estudios fueron incluidos. Se encontraron diferencias estadísticamente significativas en las intervenciones con ejercicio y las siguientes medidas de resultado, severidad de los síntomas motores (MDS-UPDRS) DME 1.44, IC 95% [-2.09 a -0.78] (p<0.001) I2= 87,9% y el equilibrio DME 0,52 IC 95% [0,30 a 0,74] (p<0.001) I2= 85,6%. En el análisis de subgrupos en la modalidad de ejercicio aeróbico, en MDS-UPDRS DME -1,28, IC 95% [-1,98 a -0,59] (p<0.001), 3 calidad de vida DME -1,91 IC 95% [-2,76 a -1,07] (p<0.001), equilibrio DME 0,54 IC 95% [0,31 a 0,77] (p<0.001), 10-m WT DME 0,15 IC 95% [0,06 a 0,25] (p<0.001) y Vo2 máximo DME -1,09 IC 95% [-1,31 a -0,88] (p=0.001), 6MWT DME 40,46 IC 95% [11,28 a 69,65] (p=0.007). Conclusiones: El ejercicio aeróbico produjo mejoras significativas en MDS UPDRS, equilibrio, calidad de vida, 10-m WT y y Vo2 máximo; mientras que el ejercicio combinado mejoró la fuerza.
dc.description.abstractBackground: Parkinson is the second most common neurodegenerative disease worldwide. Physical exercise has been considered as an effective non pharmacological strategy to improve functional impairment in patients with Parkinson. Objective: To determine the effects of the different modalities of physical exercise on the main clinical related outcomes in patients with Parkinson Disease (PD). Methods: MEDLINE, EMBASE, Scopus, CENTRAL and PEDro databases were searched up since February 1990 to February 2014 to identify randomized controlled trials (RTC’s). Further, reference lists and others related reviews were also checked. Data extraction was conducted by two independent authors. A random-effects model of meta-analysis was undertaken in presence of statistical heterogeneity (I2>50%). Publication bias was estimated using a funnel plot and the Egger’s test (p<0.05). Results: A total of 18 studies were included. Physical exercise produced significant improvements on motor symptoms severity (MDS-UPDRS) (SMD= 1.44, 95% CI -2.09 to -0.78; p<0.001) (I2= 87.9%) and balance (SMD= 0.52, 95%CI 0.30 to 0.74; p<0.001) (I2= 85.6%). In the subgroup analyses, aerobic exercise produced significant benefits on motor symptoms severity (SMD= -1.28, 95%CI 1.98 to -0.59; p<0.001), quality of life (SMD= -1.91, 95%CI -2.76 to -1.07; p<0.001), balance (SMD= 0.54, 95%CI 0.31 to 0.77; p<0.001), Vo2 max (SMD= 1.09, 95%CI -1.31 to -0.88; p=0.001) and 6 minutes walking test (SMD= 40.46, 95%CI 11.28 to 69.65; p=0.007). Conclusion: Aerobic exercise improves motor symptoms severity, balance, quality of life and aerobic capacity in patients with PD. Resistance training provides benefits on the muscular strength of these patients.
dc.format.mimetypeapplication/pdf
dc.language.isospa
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/2.5/co/
dc.sourceinstname:Universidad del Rosario
dc.sourcereponame:Repositorio Institucional EdocUR
dc.subjectEnfermedad idiopática de Parkinson
dc.subjectEjercicio
dc.subjectRevisión sistemática
dc.subjectMeta análisis
dc.subject.ddcEnfermedades 
dc.subject.lembEnfermedad de Parkinson
dc.titleEjercicio y resultados clínicos en pacientes con enfermedad de Parkinson: una revisión sistemática y metaanálisis
dc.typemasterThesis
dc.publisherUniversidad del Rosario
dc.creator.degreeMagíster en Ciencias Biomédicas
dc.publisher.programMaestría en Actividad Física y Salud
dc.publisher.departmentFacultad de medicina
dc.subject.keywordParkinson disease
dc.subject.keywordPhysical exercise
dc.subject.keywordSystematic review
dc.subject.keywordmeta analysis
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.subject.decsEnsayos clínicos -- diagnóstico
dc.subject.decsEnfermedad de Parkinson -- prevención primaria
dc.type.spaTesis de maestría
dc.rights.accesoAbierto (Texto completo)
dc.type.hasVersioninfo:eu-repo/semantics/acceptedVersion
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dc.rights.ccAtribución-NoComercial-SinDerivadas 2.5 Colombia
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