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dc.contributor.advisorBuendia, Richard 
dc.contributor.advisorRoa Rodríguez, Sandra Maricela 
dc.creatorReino Escobar, Adelaida Andrea 
dc.date.accessioned2017-07-17T18:06:21Z
dc.date.available2017-07-17T18:06:21Z
dc.date.created2017-07-10
dc.date.issued2017 
dc.identifier.urihttp://repository.urosario.edu.co/handle/10336/13537
dc.descriptionIntroducción Debido a nuevas terapias para el tratamiento del cáncer en niños, son más los sobrevivientes. Presentan frecuentemente efectos secundarios a agentes específicos. Los pacientes con tumores cerebrales, por las terapias dirigidas al sistema nervioso central, tienen mayor riesgo de presentar manifestaciones endocrinas que de no recibir un diagnóstico oportuno y manejo adecuado pueden aumentar la morbi-mortalidad en la evolución del paciente. Este estudio pretende caracterizar las manifestaciones endocrinas en sobrevivientes de tumores cerebrales, que acudieron a la consulta de endocrinología pediátrica en la Clínica Infantil Colsubsidio, Bogotá. Metodología Estudio descriptivo, retrospectivo de corte transversal. Se estableció la correlación entre el antecedente de tumor cerebral y alteraciones hormonales, que determinarían la presencia o no de manifestaciones endocrinas con otros factores asociados mediante un análisis multivariado. Resultados Se incluyeron 30 pacientes, 18 niñas (60%) y 12 niños (40%) y se encontró que de estos, 13 y 10 respectivamente, presentaron alguna manifestación endocrina. Algunos tumores cerebrales, no presentaron manifestación, otros una o varias manifestaciones endocrinas, las más frecuentes fueron baja talla, diabetes insípida, obesidad, hipotiroidismo central y pubertad precoz. Hubo valoración tardía por endocrinología pediátrica, después de la enfermedad 14.9 +/- 23,57 meses. Conclusión Los niños sobrevivientes a tumores cerebrales, pueden tener varias manifestaciones endocrinas. Se desconoce el momento exacto, en el cual presentaran alteraciones del eje hipotálamo-hipófisis por lo que deben tener un seguimiento multidisciplinario, guiado desde el punto de vista hormonal por el endocrinólogo pediatra, vigilando repercusiones sobre órganos endocrinos que pueden tener a su vez repercusiones sistémicas.
dc.description.abstractIntroduction Because of new therapies for the treatment of cancer in children, more survivors. They often have side effects to specific agents. Patients with brain tumors, due to therapies directed to the central nervous system, are at increased risk of endocrine manifestations, which, if not promptly diagnosed and adequately managed, may increase morbidity and mortality in patient evolution. This study aims to characterize endocrine manifestations in survivors of brain tumors, who attended the pediatric endocrinology consultation at the Colsubsidio Children's Clinic in Bogotá. Methodology Descriptive, retrospective cross-sectional study. The correlation between the antecedent of brain tumor and hormonal alterations was established, which would determine the presence or not of endocrine manifestations with other associated factors through a multivariate analysis. Results We included 30 patients, 18 girls (60%) and 12 children (40%), and found that of these, 13 and 10 respectively, presented some endocrine manifestation. Some brain tumors showed no manifestation, others one or more endocrine manifestations, the most frequent were low stature, diabetes insipidus, obesity, central hypothyroidism and precocious puberty. There was a late evaluation by pediatric endocrinology, after the disease 14.9 +/- 23.57 months. Conclusion Children surviving brain tumors may have several endocrine manifestations. The exact moment in which they present alterations of the hypothalamus-pituitary axis is unknown, so they must have a multidisciplinary follow-up, guided from the hormonal point of view by the pediatric endocrinologist, monitoring repercussions on endocrine organs that may have systemic repercussions
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dc.language.isospa
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/2.5/co/
dc.sourcereponame:Repositorio Institucional EdocUR
dc.sourceinstname:Universidad del Rosario
dc.subjectTumor cerebral
dc.subjectManifestación endocrina
dc.subjectSobrevivientes al cáncer
dc.subjectNiños
dc.subject.ddcEnfermedades 
dc.subject.lembEndocrinología
dc.titleCaracterización de manifestaciones endocrinológicas de pacientes pediátricos con tumores cerebrales en Clínica Infantil Colsubsidio entre 2008 - 2014
dc.typebachelorThesis
dc.publisherUniversidad del Rosario
dc.creator.degreeEspecialista en Pediatría
dc.publisher.programEspecialización en Pediatría
dc.publisher.departmentFacultad de medicina
dc.subject.keywordBrain tumor
dc.subject.keywordEndocrine manifestation
dc.subject.keywordCancer survivors
dc.subject.keywordChildren
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.subject.decsEndocrinología
dc.subject.decsNeoplasias encefálicas
dc.subject.decsHipopituitarismo
dc.subject.decsHiperprolactinemia
dc.type.spaTrabajo de grado
dc.rights.accesoAbierto (Texto completo)
dc.type.hasVersioninfo:eu-repo/semantics/acceptedVersion
dc.source.bibliographicCitationMurali Chintagumpala, Amar Gajjar. Brain Tumors. Pediatric Clinics of North America, Volumen 62 , Issue 1, February 2015, Pages 167 – 178.
dc.source.bibliographicCitationJ. W. Han, S. Y. Kwon, S. C. Won, Y. J. Shin, J. H. Ko & C. J. Lyu. Comprehensive clinical follow-up of late effects in childhood cancer survivors shows the need for early and well-timed intervention. Annals of Oncology 20: 1170–1177, 2009. doi:10.1093/annonc/mdn778.
dc.source.bibliographicCitationJames G. Gurney, Nina S. Kadan-Lottick, Roger J. Packer, Joseph P. Neglia, Charles A. Sklar, Judy A. Punyko, Marilyn Stovall, Yutaka Yasui, H. Stacy Nicholson, Suzanne Wolden, Dawn E. McNeil, Ann C. Mertens, Leslie L. Robison, Endocrine and Cardiovascular Late Effects among Adult Survivors of Childhood Brain Tumors. Cancer 2003;97:663–73. DOI 10.1002/cncr.11094.
dc.source.bibliographicCitationYoko Miyoshi , Hideaki Ohta, Yoshiko Hashii, Sadao Tokimasa, Noriyuki Namba, Sotaro Mushiake, Junichi Hara and Keiichi Ozono. Endocrinological analysis of 122 japanese childhood cancer survivors in a single hospital. Endocrine Journal 2008, 55(6), 1055-1063.
dc.source.bibliographicCitationSari Pietila, MD, Anne Makipernaa, MD, PhD, Harri Sievanen, ScD, Anna-Maija Koivisto, MSc, Tuija Wigren, MD, PhD, and Hanna L. Lenko, MD, PhD. Obesity and metabolic changes are common in young childhood brain tumor survivors. Pediatr Blood Cancer 2009; 52: 853–859. DOI 10.1002/pbc.21936.
dc.source.bibliographicCitationRobert H. Lustig, Susan R. Post, Kle ebsabai Srivannaboon, Susan R. Rose,Robert k. Danish, George A. Burghen, Xiaoping Xiong, Shengjie Wu, and Thomas E. Merchant. Risk factors for the development of obesity in children surviving brain tumors. The Journal of Clinical Endocrinology & Metabolism 88(2):611–616. doi: 10.1210/jc.2002-021180.
dc.source.bibliographicCitationPeter Kaatsch. Epidemiology of childhood cáncer. Cancer Treatment Reviews 36 (2010) 277–285. doi:10.1016/j.ctrv.2010.02.003.
dc.source.bibliographicCitationPaul A Northcott, David TW Jones, Marcel Kool, Giles W Robinson, Richard J Gilbertson, Yoon-Jae Cho, Scott L Pomeroy, Andrey Korshunov, Peter Lichter, Michael D Taylor and Stefan M Pfister. Medulloblastomics: The End of the Beginning. Nat Rev Cancer. 2012 December ; 12(12): 818–834. doi:10.1038/nrc3410.
dc.source.bibliographicCitationFausto J. Rodriguez, Kah Suan Lim, Daniel Bowers, and Charles G. Eberhart. Pathological and Molecular Advances in Pediatric Low Grade Astrocytoma. Annu Rev Pathol. 2013 January 24; 8: 361–379. doi:10.1146/annurev-pathol-020712-164009.
dc.source.bibliographicCitationMatthias Karajannis, Jeffrey C. Allen and Elizabeth W. Newcomb. Treatment of Pediatric Brain Tumors. J Cell Physiol. 2008 December ; 217(3): 584–589. doi:10.1002/jcp.21544.
dc.source.bibliographicCitationIris Fried, Uri Tabori, Tarik Tihan, Arun Reginald & Eric Bouffet. Optic pathway gliomas: a review. CNS Oncol. (2013) 2(2), 143–159.
dc.source.bibliographicCitationT. J. MacDonald, D. Aguilera, and C. M. Kramm. Treatment of high-grade glioma in children and adolescents. Neuro-Oncology 13(10):1049–1058, 2011. doi:10.1093/neuonc/nor092.
dc.source.bibliographicCitationH J Schneider, S Rovere, G Corneli , C G Croce , V Gasco , R Ruda , S Grottoli , G K Stalla , R Soffietti , E Ghigo and G Aimaretti1. Endocrine dysfunction in patients operated on for non-pituitary intracranial tumors. European Journal of Endocrinology (2006) 155 559–566.
dc.source.bibliographicCitationMehran Mahvash MD, Heinz-Herrmann Hugo MD, Homajoun Maslehaty MD, Hubertus Maximilian Mehdorn MD, Andreas Martin Stark MD. Glioblastoma Multiforme in Children: Report of 13 Cases and Review of the Literature. Pediatric Neurology 45 (2011) 178e180. doi:10.1016/j.pediatrneurol.2011.05.004.
dc.source.bibliographicCitationMatthew R Garnett, Stéphanie Puget, Jacques Grill and Christian SainteRose. Craniopharyngioma. Orphanet Journal of Rare Diseases 2007, 2:18 doi:10.1186/1750-1172-2-18.
dc.source.bibliographicCitationRobert M. Kliegman. Nelson Textbook of Pediatrics, 19th Edition 2011. Elsevier Saunders. Chapter 491.
dc.source.bibliographicCitationJoseph D. Dickerman. The Late Effects of Childhood Cancer Therapy. Department of Pediatrics, University of Vermont College of Medicine, Burlington, Vermont. www.pediatrics.org/cgi/doi/10.1542/peds.2006-2826doi:10.1542/peds.2006-2826
dc.source.bibliographicCitationStewart Goldman, Christopher D. Turner. Late Effects of Treatment for Brain Tumors. London, New York: Springer; 2009.
dc.source.bibliographicCitationAndrew A. Toogood, MD FRCP, Paul M. Stewart, FRCP, FMedSci. Hypopituitarism: Clinical Features, Diagnosis, and Management. Endocrinol Metab ClInic N Am 37 (2008) 235 – 261. Doi: 10.1016/j.ecl.2007.10.004.
dc.source.bibliographicCitationH K Gleeson and S M Shalet . The impact of cancer therapy on the endocrine system in survivors of childhood brain tumours Endocrine-Related Cancer (2004) 11 589–602.
dc.source.bibliographicCitationJames G. Gurney, Kirsten K. Ness, Marilyn Stovall, Suzanne Wolden,Judy A. Punyko, Joseph P. Neglia, Ann C. Mertens, Roger J. Packer, Leslie L. Robison, and Charles A. Sklar. Final Height and Body Mass Index among Adult Survivors of Childhood Brain Cancer: Childhood Cancer Survivor Study. J Clin Endocrinol Metab 88: 4731–4739, 2003. doi: 10.1210/jc.2003-030784.
dc.source.bibliographicCitationStephen J. Laughton, Thomas E. Merchant, Charles A. Sklar, Larry E. Kun, Maryam Fouladi, Alberto Broniscer, E. Brannon Morris, Robert P. Sanders, Matthew J. Krasin, John Shelso, Zang Xiong, Dana Wallace, and Amar Gajjar. Endocrine Outcomes for Children With Embryonal Brain Tumors After Risk-Adapted Craniospinal and Conformal Primary-Site Irradiation and High-Dose Chemotherapy With Stem-Cell Rescue on the SJMB-96 Trial. J Clin Oncol 26:1112-1118. DOI: 10.1200/JCO.2008.13.5293.
dc.source.bibliographicCitationWassim Chemaitilly and Charles A Sklar. Endocrine complications in long-term survivors of childhood cancers. Endocrine-Related Cancer (2010) 17 R141–R159. DOI: 10.1677/ERC-10-0002.
dc.source.bibliographicCitationThomas E. Merchant, Susan R. Rose, Christina Bosley, Shengjie Wu, Xiaoping Xiong, and Robert H. Lustig. Growth Hormone Secretion After Conformal Radiation Therapy in Pediatric Patients With Localized Brain Tumors. J Clin Oncol 29:4776-4780. 2011 by American Society of Clinical Oncology. DOI:
dc.source.bibliographicCitationKen H. Darzy, Suzan S. Pezzoli, Michael O. Thorner, and Stephen M. Shalet. Cranial Irradiation and Growth Hormone Neurosecretory Dysfunction: A Critical Appraisal. The Journal of Clinical Endocrinology & Metabolism 92(5):1666–1672. doi: 10.1210/jc.2006-2599.
dc.source.bibliographicCitationKen H. Darzy and Stephen M. Shalet. Department of Endocrinology, Christie Hospital NHS Trust, Wilmslow Road, Withington, Manchester. Hypopituitarism as a consequence of brain tumours and radiotherapy. Pituitary 8: 203–211, 2005. DOI: 10.1007/s11102-006-6042-4.
dc.source.bibliographicCitationKen H. Darzy Æ Stephen M. Shalet. Hypopituitarism following Radiotherapy. Pituitary (2009) 12:40–50. DOI 10.1007/s11102-008-0088-4.
dc.source.bibliographicCitationSecuelas endocrinas de la quimio/radioterapia. Sociedad Española de Endocrinología Pediatrica. Cap 27.
dc.source.bibliographicCitationAlicia Martinez, Martha Suarez, Hector Jasper, Et al. Secuelas endocrinológicas del tratamiento de enfermedades oncológicas en la infancia y adolescencia. Revista Argentina de Endocrinología y Metabolismo. Vol 46. No. 1
dc.source.bibliographicCitationThomas E. Merchant, D.O., Ph.D.,Tani Williams, R.N., B.S.N., Julie M. Smith, R.N., B.S.ED., Susan R. Rose, M.D., Robert k. Danish, M.D., George A. Burghen, M.D., Larry E. Kun, M.D., and Robert H. Lustig, M.D. Preirradiation endocrinopathies in pediatric brain tumor patients determined by dynamic tests of endocrine function. Int. J. Radiation Oncology Biol. Phys., Vol. 54, No. 1, pp. 45–50, 2002
dc.source.bibliographicCitationArnold C. Paulino, M.D. Hypothyroidism in children with medulloblastoma: a comparison of 3600 and 2340 CGY cranioespinal radiotherapy. Int. J. Radiation Oncology Biol. Phys., Vol. 53, No. 3, pp. 543–547, 2002.
dc.source.bibliographicCitationLouis S. Constine, M.d., Paul D. Woolf, M.D., Donald Cann, M.D., Gail Mick, M.D. Kenneth McCormick, M.D.,Richard F. Rauberta,Ph.D., and Philip Rubin, M.D. Hypoyhalamic pituitary dysfunction after radiation for brain tumors. The New England Journal of Medicine, Jan 14, 1993.
dc.source.bibliographicCitationSusan R. Rose. Cranial irradiation and central hypothyroidism. Trends in Endocrinology & Metabolism Vol.12 No.3 April 2001.
dc.source.bibliographicCitationLaurie E. Cohen, MD. Endocrine Late Effects of Cancer Treatment. Endocrinol Metab Clin N Am 34 (2005) 769–789.
dc.source.bibliographicCitationM Maghnie, E Uga, F Temporini, N Di Iorgi, A Secco, C Tinelli, A Papalia, MR Casini and S Loche. Evaluation of adrenal function in patients with growth hormone deficiency and hypothalamic–pituitary disorders: comparison between insulin-induced hypoglycemia, low-dose ACTH, standard ACTH and CRH stimulation tests. European Journal of Endocrinology (2005) 152 735–741.
dc.source.bibliographicCitationChristian Roth, Heinz Schmidberger, Max Lakomek, Olaf Witt, Wolfgang Wuttke, Hubertus Jarry. Reduction of g-aminobutyric acid-ergic neurotransmission as a putative mechanism of radiation induced activation of the gonadotropin releasing-hormone-pulse generator leading to precocious puberty in female rats. Neuroscience Letters 297 (2001) 45±4
dc.source.bibliographicCitationMarianne Schmiegelow, Søren Lassen, Hans Skovgaard Poulsen, Kjeld Schmiegelow, Henrik Hertz, Anna-Maria Andersson, Niels e. Skakkebæk, and Jørn Muller. Gonadal Status in Male Survivors following Childhood Brain Tumors. The Journal of Clinical Endocrinology & Metabolism.
dc.source.bibliographicCitationSari Pietila, Harri Sieva Nen, Marja Ala-Houhala, Anna-Maija, Koivisto, Hanna Liisa Lenko & Anne Ma Kipernaa. Bone mineral density is reduced in brain tumour patients treated in childhood. Acta Pædiatrica, 2006; 95: 1291_1297. DOI: 10.1080/08035250600586484.
dc.source.bibliographicCitationT. A. M. Abdu, T. A. Elhadd, R. Neary, and R. N. Clayton. Comparison of the low dose short synacthen test (1 microg), the conventional dose short synacthen test (250 microg), and the insulin tolerance test for assessment of the hypothalamo-pituitary-adrenal axis in patients with pituitary disease. The Journal of Clinical Endocrinology & Metabolism. 1999.
dc.source.bibliographicCitationEglé Ramanauskiené, Liutauras Labanauskas, Rasa Verkauskiené, Rima Sileikiené. Early development of endocrine and metabolic consequences after treatment of central nervous system tumors in children. Medicina. Volume 50, Issue 5, 2014, Pages 275 – 280. doi:10.1016/j.medici.2014.10.006.
dc.source.bibliographicCitationAyla Akca Cağlar, Aynur Oğuz, Faruk Guclu Pınarl, Ceyda Karadeniz, Arzu Okur, Aysun Bideci, Ulker Kocak, Huseyin Bora. Thyroid Abnormalities in Survivors of Childhood Cancer. J Clin Res Pediatr Endocrinol 2014;6(3):144-151. DOI:10.4274/jcrpe.1326.
dc.source.bibliographicCitationEndocinology expected values & S. I. Unit conversión tables. Laboratory Corporation of América Holdings All rights reserved
dc.source.bibliographicCitationUrquhart, T., & Collin, J. Understanding the endocrinopathies associated with the treatment of childhood cancer: part 2. Nursing children and young people, (2016). 28(9), 36-43.
dc.source.bibliographicCitationOgilvy-Stuart AL, Shalet SM. Growth and puberty after growth hormone treatment after irradiation for brain tumours. Archives of Disease in Childhood. 1995;73(2):141-146.
dc.source.bibliographicCitationWang, Zhi-Feng et al. Growth hormone treatment and risk of recurrence or development of secondary neoplasms in survivors of pediatric brain tumors. Journal of Clinical Neuroscience , Volume 21 , Issue 12 , (2014) 2155 – 2159.
dc.source.bibliographicCitationBogarin, R. & Steinbok. Growth hormone treatment and risk of recurrence or progression of brain tumors in children: a review, P. Childs Nerv Syst (2009) 25: 273-279.
dc.source.bibliographicCitationMostoufi-Moab, S., Seidel, K., Leisenring, W. M., Armstrong, G. T., Oeffinger, K. C., Stovall, M.& Robison, L. L. Endocrine abnormalities in aging survivors of childhood cancer: A report from the Childhood Cancer Survivor Study. Journal of Clinical Oncology, (2016). 34(27), 3240-3247.
dc.source.bibliographicCitationRutter, M. M., & Rose, S. R. Long-term endocrine sequelae of childhood cancer. Current opinion in pediatrics, (2007). 19(4), 480-487.
dc.source.bibliographicCitationFelicetti, F., Fortunati, N., Arvat, E., & Brignardello, E. GH deficiency in adult survivors of childhood cancer. Best Practice & Research Clinical Endocrinology & Metabolism, (2016). 30(6), 795-804.
dc.source.bibliographicCitationRose, S. R., Horne, V. E., Howell, J., Lawson, S. A., Rutter, M. M., Trotman, G. E., & Corathers, S. D. Late endocrine effects of childhood cancer. Nature Reviews Endocrinology, 12(6), 319-336.
dc.source.bibliographicCitationNeville, K. A. (2016)., & Cohn, R. J. Bone health in survivors of childhood cancer. The lancet. Diabetes & endocrinology, (2015). 3(7), 496.
dc.source.bibliographicCitationGunn Harriet M., Rinne Ida, Emilsson Hanna, Gabriel Melissa, Maguire Ann M., and Steinbeck Katharine S. Primary Gonadal Insufficiency in Male and Female Childhood Cancer Survivors in a Long-Term Follow-Up Clinic. Journal of Adolescent and Young Adult Oncology. December 2016, 5(4): 344-350.
dc.source.bibliographicCitationNandagopal, R., Laverdière, C., Mulrooney, D., Hudson, M. M., & Meacham, L. (2008). Endocrine late effects of childhood cancer therapy: a report from the Children’s Oncology Group. Hormone Research in Paediatrics, 69(2), 65-74.
dc.source.bibliographicCitationChemaitilly, W., & Cohen, L. E. (2017). Diagnosis of endocrine disease: Endocrine late-effects of childhood cancer and its treatments. European Journal of Endocrinology, 176(4), R183-R203.
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