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dc.creatorJongbloed, Franny 
dc.creatorde Bruin, Ron W. F. 
dc.creatorPennings, Jeroen L. A. 
dc.creatorPayán-Gómez, César 
dc.creatorEngel, Sandra van den 
dc.creatorOostrom, Conny T. van 
dc.creatorde Bruin, Alain 
dc.creatorHoeijmakers, Jan H. J. 
dc.creatorSteeg, Harry van 
dc.creatorIJzermans, Jan N. M. 
dc.creatorDollé, Martijn E. T. 
dc.date.accessioned2018-11-19T15:04:32Z
dc.date.available2018-11-19T15:04:32Z
dc.date.created2014
dc.date.issued2014 
dc.identifier.issnISSN 1932-6203
dc.identifier.urihttp://repository.urosario.edu.co/handle/10336/18701
dc.descriptionIschemia-reperfusion injury (IRI) is inevitable during kidney transplantation leading to oxidative stress and inflammation. We previously reported that preoperative fasting in young-lean male mice protects against IRI. Since patients are generally of older age with morbidities possibly leading to a different response to fasting, we investigated the effects of preoperative fasting on renal IRI in aged-overweight male and female mice. Male and female F1-FVB/C57BL6-hybrid mice, average age 73 weeks weighing 47.2 grams, were randomized to preoperative ad libitum feeding or 3 days fasting, followed by renal IRI. Body weight, kidney function and survival of the animals were monitored until day 28 postoperatively. Kidney histopathology was scored for all animals and gene expression profiles after fasting were analyzed in kidneys of young and aged male mice. Preoperative fasting significantly improved survival after renal IRI in both sexes compared with normal fed mice. Fasted groups had a better kidney function shown by lower serum urea levels after renal IRI. Histopathology showed less acute tubular necrosis and more regeneration in kidneys from fasted mice. A mRNA analysis indicated the involvement of metabolic processes including fatty acid oxidation and retinol metabolism, and the NRF2-mediated stress response. Similar to young-lean, healthy male mice, preoperative fasting protects against renal IRI in aged-overweight mice of both genders. These findings suggest a general protective response of fasting against renal IRI regardless of age, gender, body weight and genetic background. Therefore, fasting could be a non-invasive intervention inducing increased oxidative stress resistance in older and overweight patients as well. © 2014 Jongbloed et al.
dc.format.mimetypeapplication/pdf
dc.language.isoeng
dc.relation.ispartofPLoS ONE, ISSN: 1932-6203, Vol. 9/No. 6 (2014)
dc.relation.urihttps://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0100853&type=printable
dc.rights.uri
dc.subjectGlutathione Transferase A2
dc.subjectMessenger Rna
dc.subjectRetinol
dc.subjectTranscription Factor Nrf2
dc.subjectUrea
dc.subjectAge Distribution
dc.subjectAged
dc.subjectAnimal Experiment
dc.subjectAnimal Model
dc.subjectAnimal Tissue
dc.subjectArticle
dc.subjectBody Weight
dc.subjectControlled Study
dc.subjectCyp4A14 Dgene
dc.subjectDiet Restriction
dc.subjectFatty Acid Oxidation
dc.subjectFemale
dc.subjectGene
dc.subjectGene Expression Profiling
dc.subjectGsta2 Gene
dc.subjectHistopathology
dc.subjectKidney Function
dc.subjectKidney Injury
dc.subjectKidney Ischemia
dc.subjectKidney Tubule Necrosis
dc.subjectMale
dc.subjectMouse
dc.subjectNonhuman
dc.subjectNucleotide Sequence
dc.subjectObesity
dc.subjectPpara Gene
dc.subjectPreoperative Period
dc.subjectRenal Protection
dc.subjectReperfusion Injury
dc.subjectSc4Mol Gene
dc.subjectStress
dc.subjectSurvival Rate
dc.subjectTissue Regeneration
dc.subjectUrea Blood Level
dc.subjectVitamin Metabolism
dc.subjectAdverse Effects
dc.subjectAge
dc.subjectAnimal
dc.subjectC57Bl Mouse
dc.subjectKidney
dc.subjectKidney Transplantation
dc.subjectMetabolism
dc.subjectObesity
dc.subjectOxidative Stress
dc.subjectPathology
dc.subjectReperfusion Injury
dc.subjectUrea Nitrogen Blood Level
dc.subjectAge Factors
dc.subjectAnimals
dc.subjectBlood Urea Nitrogen
dc.subjectFasting
dc.subjectFemale
dc.subjectKidney
dc.subjectKidney Transplantation
dc.subjectMale
dc.subjectMetabolic Networks And Pathways
dc.subjectMice
dc.subjectMice, Inbred C57Bl
dc.subjectOverweight
dc.subjectOxidative Stress
dc.subjectReperfusion Injury
dc.subject.lembTrasplante de riñon
dc.subject.lembIsquemia
dc.subject.lembReperfusión
dc.titlePreoperative fasting protects against renal ischemia-reperfusion injury in aged and overweight mice
dc.typearticle
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.type.spaArtículo
dc.rights.accesoAbierto (Texto Completo)
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.source.bibliographicCitationTonelli, M., Wiebe, N., Knoll, G., Bello, A., Browne, S., Systematic review: Kidney transplantation compared with dialysis in clinically relevant outcomes (2011) Am J Transplant, 11, pp. 2093-2109
dc.rights.cchttps://creativecommons.org/licenses/by/4.0/
dc.creator.googleJongbloed, Franny
dc.creator.googlede Bruin, Ron W. F.
dc.creator.googlePennings, Jeroen L. A.
dc.creator.googlePayán-Gómez, César
dc.creator.googleEngel, Sandra van den
dc.creator.googleOostrom, Conny T. van
dc.creator.googlede Bruin, Alain
dc.creator.googleHoeijmakers, Jan H. J.
dc.creator.googleSteeg, Harry van
dc.creator.googleIJzermans, Jan N. M.
dc.creator.googleDollé, Martijn E. T.


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