dc.creator | Jongbloed, Franny |
dc.creator | de Bruin, Ron W. F. |
dc.creator | Pennings, Jeroen L. A. |
dc.creator | Payán-Gómez, César |
dc.creator | Engel, Sandra van den |
dc.creator | Oostrom, Conny T. van |
dc.creator | de Bruin, Alain |
dc.creator | Hoeijmakers, Jan H. J. |
dc.creator | Steeg, Harry van |
dc.creator | IJzermans, Jan N. M. |
dc.creator | Dollé, Martijn E. T. |
dc.date.accessioned | 2018-11-19T15:04:32Z |
dc.date.available | 2018-11-19T15:04:32Z |
dc.date.created | 2014 |
dc.date.issued | 2014 |
dc.identifier.issn | ISSN 1932-6203 |
dc.identifier.uri | http://repository.urosario.edu.co/handle/10336/18701 |
dc.description | Ischemia-reperfusion injury (IRI) is inevitable during kidney transplantation leading to oxidative stress and inflammation. We previously reported that preoperative fasting in young-lean male mice protects against IRI. Since patients are generally of older age with morbidities possibly leading to a different response to fasting, we investigated the effects of preoperative fasting on renal IRI in aged-overweight male and female mice. Male and female F1-FVB/C57BL6-hybrid mice, average age 73 weeks weighing 47.2 grams, were randomized to preoperative ad libitum feeding or 3 days fasting, followed by renal IRI. Body weight, kidney function and survival of the animals were monitored until day 28 postoperatively. Kidney histopathology was scored for all animals and gene expression profiles after fasting were analyzed in kidneys of young and aged male mice. Preoperative fasting significantly improved survival after renal IRI in both sexes compared with normal fed mice. Fasted groups had a better kidney function shown by lower serum urea levels after renal IRI. Histopathology showed less acute tubular necrosis and more regeneration in kidneys from fasted mice. A mRNA analysis indicated the involvement of metabolic processes including fatty acid oxidation and retinol metabolism, and the NRF2-mediated stress response. Similar to young-lean, healthy male mice, preoperative fasting protects against renal IRI in aged-overweight mice of both genders. These findings suggest a general protective response of fasting against renal IRI regardless of age, gender, body weight and genetic background. Therefore, fasting could be a non-invasive intervention inducing increased oxidative stress resistance in older and overweight patients as well. © 2014 Jongbloed et al. |
dc.format.mimetype | application/pdf |
dc.language.iso | eng |
dc.relation.ispartof | PLoS ONE, ISSN: 1932-6203, Vol. 9/No. 6 (2014) |
dc.relation.uri | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0100853&type=printable |
dc.rights.uri | |
dc.subject | Glutathione Transferase A2 |
dc.subject | Messenger Rna |
dc.subject | Retinol |
dc.subject | Transcription Factor Nrf2 |
dc.subject | Urea |
dc.subject | Age Distribution |
dc.subject | Aged |
dc.subject | Animal Experiment |
dc.subject | Animal Model |
dc.subject | Animal Tissue |
dc.subject | Article |
dc.subject | Body Weight |
dc.subject | Controlled Study |
dc.subject | Cyp4A14 Dgene |
dc.subject | Diet Restriction |
dc.subject | Fatty Acid Oxidation |
dc.subject | Female |
dc.subject | Gene |
dc.subject | Gene Expression Profiling |
dc.subject | Gsta2 Gene |
dc.subject | Histopathology |
dc.subject | Kidney Function |
dc.subject | Kidney Injury |
dc.subject | Kidney Ischemia |
dc.subject | Kidney Tubule Necrosis |
dc.subject | Male |
dc.subject | Mouse |
dc.subject | Nonhuman |
dc.subject | Nucleotide Sequence |
dc.subject | Obesity |
dc.subject | Ppara Gene |
dc.subject | Preoperative Period |
dc.subject | Renal Protection |
dc.subject | Reperfusion Injury |
dc.subject | Sc4Mol Gene |
dc.subject | Stress |
dc.subject | Survival Rate |
dc.subject | Tissue Regeneration |
dc.subject | Urea Blood Level |
dc.subject | Vitamin Metabolism |
dc.subject | Adverse Effects |
dc.subject | Age |
dc.subject | Animal |
dc.subject | C57Bl Mouse |
dc.subject | Kidney |
dc.subject | Kidney Transplantation |
dc.subject | Metabolism |
dc.subject | Obesity |
dc.subject | Oxidative Stress |
dc.subject | Pathology |
dc.subject | Reperfusion Injury |
dc.subject | Urea Nitrogen Blood Level |
dc.subject | Age Factors |
dc.subject | Animals |
dc.subject | Blood Urea Nitrogen |
dc.subject | Fasting |
dc.subject | Female |
dc.subject | Kidney |
dc.subject | Kidney Transplantation |
dc.subject | Male |
dc.subject | Metabolic Networks And Pathways |
dc.subject | Mice |
dc.subject | Mice, Inbred C57Bl |
dc.subject | Overweight |
dc.subject | Oxidative Stress |
dc.subject | Reperfusion Injury |
dc.subject.lemb | Trasplante de riñon |
dc.subject.lemb | Isquemia |
dc.subject.lemb | Reperfusión |
dc.title | Preoperative fasting protects against renal ischemia-reperfusion injury in aged and overweight mice |
dc.type | article |
dc.rights.accesRights | info:eu-repo/semantics/openAccess |
dc.type.spa | Artículo |
dc.rights.acceso | Abierto (Texto Completo) |
dc.type.hasVersion | info:eu-repo/semantics/publishedVersion |
dc.source.bibliographicCitation | Tonelli, M., Wiebe, N., Knoll, G., Bello, A., Browne, S., Systematic review: Kidney transplantation compared with dialysis in clinically relevant outcomes (2011) Am J Transplant, 11, pp. 2093-2109 |
dc.rights.cc | https://creativecommons.org/licenses/by/4.0/ |
dc.creator.google | Jongbloed, Franny |
dc.creator.google | de Bruin, Ron W. F. |
dc.creator.google | Pennings, Jeroen L. A. |
dc.creator.google | Payán-Gómez, César |
dc.creator.google | Engel, Sandra van den |
dc.creator.google | Oostrom, Conny T. van |
dc.creator.google | de Bruin, Alain |
dc.creator.google | Hoeijmakers, Jan H. J. |
dc.creator.google | Steeg, Harry van |
dc.creator.google | IJzermans, Jan N. M. |
dc.creator.google | Dollé, Martijn E. T. |