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dc.creatorLópez, Carolina 
dc.creatorSuárez, Carlos F. 
dc.creatorCadavid, Luis 
dc.creatorPatarroyo, Manuel E. 
dc.creatorPatarroyo, Manuel A. 
dc.date.accessioned2018-11-19T15:46:28Z
dc.date.available2018-11-19T15:46:28Z
dc.date.created2014
dc.date.issued2014 
dc.identifier.issnISSN 1932-6203
dc.identifier.urihttp://repository.urosario.edu.co/handle/10336/18702
dc.descriptionNon-human primates belonging to the Aotus genus have been shown to be excellent experimental models for evaluating drugs and vaccine candidates against malaria and other human diseases. The immune system of this animal model must be characterised to assess whether the results obtained here can be extrapolated to humans. Class I and II major histocompatibility complex (MHC) proteins are amongst the most important molecules involved in response to pathogens; in spite of this, the techniques available for genotyping these molecules are usually expensive and/or time-consuming. Previous studies have reported MHC-DRB class II gene typing by microsatellite in Old World primates and humans, showing that such technique provides a fast, reliable and effective alternative to the commonly used ones. Based on this information, a microsatellite present in MHC-DRB intron 2 and its evolutionary patterns were identified in two Aotus species (A. vociferans and A. nancymaae ), as well as its potential for genotyping class II MHC-DRB in these primates. © 2014 López et al.
dc.format.mimetypeapplication/pdf
dc.language.isoeng
dc.relation.ispartofPLoS ONE, ISSN: 1932-6203, Vol. 9/No. 5 (2014)
dc.relation.urihttps://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0096973&type=printable
dc.rights.uri
dc.subjectComplementary Dna
dc.subjectHla Dr Antigen
dc.subjectHla Drb1 Antigen
dc.subjectHla Drb3 Antigen
dc.subjectMajor Histocompatibility Antigen Class 1
dc.subjectMajor Histocompatibility Antigen Class 2
dc.subjectHla Antigen Class 2
dc.subjectMicrosatellite Dna
dc.subjectAdult
dc.subjectAllele
dc.subjectAnimal Cell
dc.subjectAotus Nancymaae
dc.subjectAotus Vociferans
dc.subjectArticle
dc.subjectControlled Study
dc.subjectDna Sequence
dc.subjectExon
dc.subjectGenetic Analysis
dc.subjectGenotype
dc.subjectGenotyping Technique
dc.subjectIntron
dc.subjectMhc Drb Gene
dc.subjectMhc Drb1 Gene
dc.subjectMhc Drb3 Gene
dc.subjectMicrosatellite Marker
dc.subjectMolecular Evolution
dc.subjectMolecular Phylogeny
dc.subjectNonhuman
dc.subjectPhylogenetic Tree
dc.subjectPlatyrrhini
dc.subjectSequence Alignment
dc.subjectShort Tandem Repeat
dc.subjectAnimal
dc.subjectAotidae
dc.subjectGenetics
dc.subjectAnimals
dc.subjectAotidae
dc.subjectGenotyping Techniques
dc.subjectHistocompatibility Antigens Class Ii
dc.subjectIntrons
dc.subjectMicrosatellite Repeats
dc.subject.lembMalaria
dc.subject.lembHistocompatibilidad
dc.subject.lembExperimentación con animales
dc.subject.lembPrimates
dc.titleCharacterising a microsatellite for DRB typing in Aotus vociferans and Aotus nancymaae (Platyrrhini)
dc.typearticle
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.type.spaArtículo
dc.rights.accesoAbierto (Texto Completo)
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.source.bibliographicCitationWard, J.M., Vallender, E.J., The resurgence and genetic implications of New World primates in biomedical research (2012) Trends Genet, 28, pp. 586-591
dc.rights.cchttps://creativecommons.org/licenses/by/4.0/
dc.creator.googleLópez, Carolina
dc.creator.googleSuárez, Carlos F.
dc.creator.googleCadavid, Luis F.
dc.creator.googlePatarroyo, Manuel E.
dc.creator.googlePatarroyo, Manuel A.


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