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dc.creatorCastellsagué, Xavier 
dc.creatorAult, Kevin A. 
dc.creatorBosch, F. Xavier 
dc.creatorBrown, Darron 
dc.creatorCuzick, Jack 
dc.creatorFerris, Daron G. 
dc.creatorJoura, Elmar A. 
dc.creatorGarland, Suzanne M. 
dc.creatorGiuliano, Anna R 
dc.creatorHernandez-Avila, Mauricio 
dc.creatorHuh, Warner 
dc.creatorIversen, Ole-Erik 
dc.creatorKjaer, Susanne K. 
dc.creatorLuna, Joaquin 
dc.creatorMonsonego, Joseph 
dc.creatorMuñoz, Nubia 
dc.creatorMyers, Evan 
dc.creatorPaavonen, Jorma 
dc.creatorPitisuttihum, Punnee 
dc.creatorSteben, Marc 
dc.creatorWheeler, Cosette M. 
dc.creatorPerez, Gonzalo 
dc.creatorSaah, Alfred 
dc.creatorPitisuttihum, Punnee 
dc.creatorSteben, Marc 
dc.creatorWheeler, Cosette M. 
dc.creatorPerez, Gonzalo 
dc.creatorSaah, Alfred 
dc.creatorLuxembourg, Alain 
dc.creatorSings, Heather L 
dc.creatorVelicer, Christine 
dc.date.accessioned2019-01-22T16:23:31Z
dc.date.available2019-01-22T16:23:31Z
dc.date.created2016
dc.date.issued2016 
dc.identifier.issnISSN 2405-8521
dc.identifier.urihttp://repository.urosario.edu.co/handle/10336/18903
dc.descriptionBackground: We estimated the proportion of cervical intraepithelial neoplasia (CIN) cases attributed to 14 HPV types, including quadrivalent (qHPV) (6/11/16/18) and 9-valent (9vHPV) (6/11/16/18/31/33/45/52/58) vaccine types, by region. Methods: Women ages 15-26 and 24-45 years from 5 regions were enrolled in qHPV vaccine clinical trials. Among 10,706 women (placebo arms), 1539 CIN1, 945 CIN2/3, and 24 adenocarcinoma in situ (AIS) cases were diagnosed by pathology panel consensus. Results: Predominant HPV types were 16/51/52/56 (anogenital infection), 16/39/51/52/56 (CIN1), and 16/31/52/58 (CIN2/3). In regions with largest sample sizes, minimal regional variation was observed in 9vHPV type prevalence in CIN1 (~50%) and CIN2/3 (81-85%). Types 31/33/45/52/58 accounted for 25-30% of CIN1 in Latin America and Europe, but 14-18% in North America and Asia. Types 31/33/45/52/58 accounted for 33-38% of CIN2/3 in Latin America (younger women), Europe, and Asia, but 17-18% of CIN2/3 in Latin America (older women) and North America. Non-vaccine HPV types 35/39/51/56/59 had similar or higher prevalence than qHPV types in CIN1 and were attributed to 2-11% of CIN2/3. Conclusions: The 9vHPV vaccine could potentially prevent the majority of CIN1-3, irrespective of geographic region. Notwithstanding, non-vaccine types 35/39/51/56/59 may still be responsible for some CIN1, and to a lesser extent CIN2/3. © 2016 The Authors.
dc.format.mimetypeapplication/pdf
dc.language.isoeng
dc.relation.ispartofPapillomavirus Research, ISSN: 2405-8521, Vol. 2 (2016) pp. 61-69
dc.relation.urihttps://ac.els-cdn.com/S2405852116000045/1-s2.0-S2405852116000045-main.pdf?_tid=4b0c0ae3-4d15-4359-a3c9-f9aa1f8e773a&acdnat=1540055637_03fa2081b10b81e09218a0ae8399ca86
dc.rights.uri
dc.subjectHuman papillomavirus
dc.subjectCervical cancer
dc.subjectCervical intraepithelial neoplasia
dc.subjectAdenocarcinoma in situ
dc.subject.ddcEnfermedades 
dc.subject.lembPapiloma
dc.subject.lembNeoplasmas
dc.subject.lembAdenocarcinoma in Situ
dc.titleHuman papillomavirus detection in cervical neoplasia attributed to 12 high-risk human papillomavirus genotypes by region
dc.typearticle
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.subject.decsWart Virus Vaccine
dc.subject.decsAdenocarcinoma In Situ
dc.subject.decsAge Distribution
dc.subject.decsArticle
dc.subject.decsCondyloma Acuminatum
dc.subject.decsGenotype
dc.subject.decsGeographic Distribution
dc.subject.decsHealth Program
dc.subject.decsHuman
dc.subject.decsHuman Papillomavirus Type 11
dc.subject.decsHuman Papillomavirus Type 16
dc.subject.decsHuman Papillomavirus Type 18
dc.subject.decsHuman Papillomavirus Type 31
dc.subject.decsHuman Papillomavirus Type 33
dc.subject.decsHuman Papillomavirus Type 45
dc.subject.decsHuman Papillomavirus Type 52
dc.subject.decsHuman Papillomavirus Type 58
dc.subject.decsHuman Papillomavirus Type 6
dc.subject.decsImmunization
dc.subject.decsInfection Risk
dc.subject.decsMixed Infection
dc.subject.decsMolecular Epidemiology
dc.subject.decsNonhuman
dc.subject.decsPrevalence
dc.subject.decsPriority Journal
dc.subject.decsSystematic Review
dc.subject.decsUterine Cervix Carcinoma In Situ
dc.subject.decsVirus Detection
dc.subject.decsWart Virus
dc.subject.decsAdenocarcinoma
dc.subject.decsAdolescent
dc.subject.decsAdult
dc.subject.decsAsia
dc.subject.decsClassification
dc.subject.decsEurope
dc.subject.decsFemale
dc.subject.decsGenetics
dc.subject.decsIsolation And Purification
dc.subject.decsMiddle Aged
dc.subject.decsNorth America
dc.subject.decsPapillomaviridae
dc.subject.decsRandomized Controlled Trial (Topic)
dc.subject.decsSouth And Central America
dc.subject.decsUterine Cervix Carcinoma In Situ
dc.subject.decsVirology
dc.subject.decsYoung Adult
dc.subject.decsAdenocarcinoma
dc.subject.decsAdolescent
dc.subject.decsAdult
dc.subject.decsAsia
dc.subject.decsCervical Intraepithelial Neoplasia
dc.subject.decsEurope
dc.subject.decsFemale
dc.subject.decsGenotype
dc.subject.decsHumans
dc.subject.decsLatin America
dc.subject.decsMiddle Aged
dc.subject.decsNorth America
dc.subject.decsPapillomaviridae
dc.subject.decsRandomized Controlled Trials As Topic
dc.subject.decsYoung Adult
dc.type.spaArtículo
dc.rights.accesoAbierto (Texto Completo)
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.source.bibliographicCitationJoura, E.A., Giuliano, A.R., Iversen, O.E., Bouchard, C., Mao, C., Mehlsen, J., A 9-valent HPV vaccine against infection and intraepithelial neoplasia in women (2015) N. Engl. J. Med., 372, pp. 711-723
dc.rights.cchttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.creator.googleCastellsagué X., Ault K.A., Bosch F.X., Brown D., Cuzick J., Ferris D.G., Joura E.A., Garland S.M., Giuliano A.R., Hernandez-Avila M., Huh W., Iversen O.-E., Kjaer S.K., Luna J., Monsonego J., Muñoz N., Myers E., Paavonen J., Pitisuttihum P., Steben M., Wheeler C.M., Perez G., Saah A., Luxembourg A., Sings H.L., Velicer C.
dc.creator.googleCastellsagué, Xavier
dc.creator.googleAult, Kevin A.
dc.creator.googleBosch, F. Xavier
dc.creator.googleBrown, Darron
dc.creator.googleCuzick, Jack
dc.creator.googleFerris, Daron G.
dc.creator.googleJoura, Elmar A.
dc.creator.googleGarland, Suzanne M.
dc.creator.googleGiuliano, Anna R
dc.creator.googleHernandez-Avila, Mauricio
dc.creator.googleHuh, Warner
dc.creator.googleIversen, Ole-Erik
dc.creator.googleKjaer, Susanne K.
dc.creator.googleLuna, Joaquin
dc.creator.googleMonsonego, Joseph
dc.creator.googleMuñoz, Nubia
dc.creator.googleMyers, Evan
dc.creator.googlePaavonen, Jorma
dc.creator.googlePitisuttihum, Punnee
dc.creator.googleSteben, Marc
dc.creator.googleWheeler, Cosette M.
dc.creator.googlePerez, Gonzalo
dc.creator.googleSaah, Alfred
dc.creator.googlePitisuttihum, Punnee
dc.creator.googleSteben, Marc
dc.creator.googleWheeler, Cosette M.
dc.creator.googlePerez, Gonzalo
dc.creator.googleSaah, Alfred
dc.creator.googleLuxembourg, Alain
dc.creator.googleSings, Heather L
dc.creator.googleVelicer, Christine


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