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dc.creatorBermudez, Adriana 
dc.creatorAlba, Martha P. 
dc.creatorVanegas, Magnolia 
dc.creatorPatarroyo, Manuel A. 
dc.creatorPatarroyo, Manuel E. 
dc.date.accessioned2019-10-01T13:58:59Z
dc.date.available2019-10-01T13:58:59Z
dc.date.created2018
dc.date.issued2018
dc.identifier.issn2296-2646
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/20372
dc.descriptionThe 3D structural analysis of 62 peptides derived from highly pathogenic Plasmodium falciparum malaria parasite proteins involved in host cell invasion led to finding a striking association between particular β-turn types located in the N-terminal peripheral flanking residue region (preceding the polyproline II left-handed structures fitting into the HLA-DRβ* allele family) and modified immune protection-inducing protein structure induced long-lasting protective immunity. This is the first time association between two different secondary structures associated with a specific immunological function has been described: full, long-lasting protective immunity. © 2018 Bermudez, Alba, Vanegas, Patarroyo and Patarroyo.
dc.format.mimetypeapplication/pdf
dc.language.isoeng
dc.relation.ispartofFrontiers in Chemistry, ISSN:2296-2646, Vol. 6 (2018)
dc.relation.urihttps://www.frontiersin.org/articles/10.3389/fchem.2018.00106/full
dc.subjectVacuna contra la malaria
dc.subject.ddcEnfermedades 
dc.subject.lembMalaria
dc.subject.lembPlasmodium
dc.titleSpecific β-Turns Precede PPIIL Structures Binding to Allele-Specific HLA-DRβ1 ∗ PBRs in Fully-Protective Malaria Vaccine Components
dc.typearticle
dc.subject.keywordβ-turns
dc.subject.keywordStructure-function
dc.subject.keywordIMPIPS
dc.subject.keywordLLPI
dc.subject.keywordPPIIL
dc.subject.keywordMalaria vaccine
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.type.spaArtículo
dc.rights.accesoAbierto (Texto Completo)
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.source.bibliographicCitationAdzhubei, A.A., Sternberg, M.J., Makarov, A.A., Polyproline-II helix in proteins: structure and function (2013) J. Mol. Biol, 425, pp. 2100-2132
dc.creator.googleBermudez, Adriana
dc.creator.googleAlba, Martha P.
dc.creator.googleVanegas, Magnolia
dc.creator.googlePatarroyo, Manuel A.
dc.creator.googlePatarroyo, Manuel E.
dc.identifier.doi10.3389/fchem.2018.00106


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