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dc.creatorLaissue, Paul 
dc.creatorLakha, Besma 
dc.creatorVatin, Magalie 
dc.creatorBatista, Frank 
dc.creatorBurgio, Gaetan 
dc.creatorMercier, Eric 
dc.creatorDos Santos, Esther 
dc.creatorBuffat, Christophe 
dc.creatorSierra Diaz, Diana Carolina 
dc.creatorRenault, Gilles 
dc.creatorMontagutelli, Xavier 
dc.creatorSalmon, Jane 
dc.creatorMonget, Philippe 
dc.creatorVeitia, Reiner 
dc.creatorMeháts, Céline 
dc.creatorFellous, Marc 
dc.creatorGris, Jean-Christophe 
dc.creatorCocquet, Julie 
dc.creatorVaiman, Daniel 
dc.date.accessioned2020-05-12T00:22:30Z
dc.date.available2020-05-12T00:22:30Z
dc.date.created2016-10-01
dc.date.issued2016
dc.identifier.issn2046-2441
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/21963
dc.description.abstractRecurrent spontaneous abortion (RSA) is a common cause of infertility, but previous attempts at identifying RSA causative genes have been relatively unsuccessful. Such failure to describe RSA aetiological genes might be explained by the fact that reproductive phenotypes should be considered as quantitative traits resulting from the intricate interaction of numerous genetic, epigenetic and environmental factors. Here, we studied an interspecific recombinant congenic strain (IRCS) of Mus musculus from the C57BL6/J strain of mice harbouring an approximate 5 Mb DNA fragment from chromosome 13 from Mus spretus mice (66H-MMU13 strain), with a high rate of embryonic resorption (ER). Transcriptome analyses of endometrial and placental tissues from these mice showed a deregulation of many genes associated with the coagulation and inflammatory response pathways. Bioinformatics approaches led us to select Foxd1 as a candidate gene potentially related to ER and RSA. Sequencing analysis of Foxd1 in the 66H-MMU13 strain, and in 556 women affected by RSA and 271 controls revealed non-synonymous sequence variants. In vitro assays revealed that some led to perturbations in FOXD1 transactivation properties on promoters of genes having key roles during implantation/placentation, suggesting a role of this gene in mammalian implantation processes. © 2016 The Authors.
dc.format.mimetypeapplication/pdf
dc.language.isoeng
dc.relation.ispartofOpen biology, ISSN: 2046-2441 Vol. 6, No. 10 (Septiembre 2016); 13 pp.
dc.relation.urihttps://royalsocietypublishing.org/doi/10.1098/rsob.160109
dc.subject.ddcEvolución & genética 
dc.subject.ddcGinecología & otras especialidades médicas 
dc.titleAssociation of FOXD1 variants with adverse pregnancy outcomes in mice and humans
dc.typearticle
dc.subject.keywordDevelopmental biology
dc.subject.keywordGenetics
dc.subject.keywordGenomics
dc.subject.keywordFOXD1 protein
dc.subject.keywordEmbryo death
dc.subject.keywordRecurrent spontaneous abortion
dc.subject.keywordInterspecific recombinant congenic mice
dc.subject.keywordDNA microarray
dc.subject.keywordForkhead transcription factor
dc.subject.keywordChlorocebus aethiops
dc.subject.keywordC57BL mouse
dc.subject.keywordCV-1 cell line
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.type.spaArtículo
dc.rights.accesoAbierto (Texto Completo)
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.creator.googleLaissue, P.
dc.creator.googleLakhal, B.
dc.creator.googleVatin, M.
dc.creator.googleBatista, F.
dc.creator.googleBurgio, G.
dc.creator.googleMercier, E.
dc.creator.googleSantos, E.D.
dc.creator.googleBuffat, C.
dc.creator.googleSierra-Diaz, D.C.
dc.creator.googleRenault, G.
dc.creator.googleMontagutelli, X.
dc.creator.googleSalmon, J.
dc.creator.googleMonget, P.
dc.creator.googleVeitia, R.A.
dc.creator.googleMéhats, C.
dc.creator.googleFellous, M.
dc.creator.googleGris, J.-C.
dc.creator.googleCocquet, J.
dc.creator.googleVaiman, D.
dc.identifier.doihttps://doi.org/10.1098/rsob.160109


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