Peri-articular injection of an analgesic mixture in primary total hip arthroplasty: an effective strategy for pain control during the first post-operative day
"Background: Previous studies of soft tissue infiltration in hip arthroplasty present variable results. The purpose of this study is to identify whether injection of an analgesic mixture improves pain management during the immediate post-operative period. Materials and methods: This cohort study compared 129 patients that received peri-articular soft tissue injection with 20 ml of 0.25% bupivacaine and 2 ml of ketorolac (30 mg/1 ml) in 28 ml of saline solution, with 71 patients who did not received injections. Pain intensity in the Verbal Analog Scale (VAS), opioid titration, and consumption (mg morphine equivalents) in the post-anaesthetic care unit (PACU) and during the first post-operative day were assessed for both groups. All patients received the same analgesia protocol. Results: Median VAS score in the PACU was 4 (IQR 2–7) in the injection group and 7 (IQR 4–8) in the non-injection group (p = 0.001). Median opioid titration was 0 mg for the injection group and 2.6 mg for the non-injection group (p = 0.011). In the first post-operative day, the difference in VAS scores between groups was statistically significant (p = 0.009), but there was no difference in opioid consumption. Conclusion: Soft tissue injection with local anesthetics and non-steroidal anti-inflammatory drugs allows adequate pain control in the immediate post-operative period and reduces the requirement for opioid consumption. We recommend the implementation of this safe and effective strategy in post-operative pain management after primary hip arthroplasty. Level of evidence: Level II, cohort study. © 2018, SICOT aisbl."
Analgesic agent ; intra-articular ; postoperative ; opioid ; non-steroidal ; local ; combination ; replacement ; Bupivacaine ; hip ; Fentanyl ; Hydromorphone ; Ketamine ; Ketorolac ; Morphine ; Opiate derivative ; Oxycodone ; Paracetamol ; Sodium chloride ; Tranexamic acid ; Bupivacaine ; Ketorolac ; Local anesthetic agent ; Narcotic analgesic agent ; Nonsteroid antiinflammatory agent ; Adult ; Aged ; Analgesia ; Article ; Clinical assessment ; Clinical effectiveness ; Clinical protocol ; Cohort analysis ; Controlled study ; Drug dose titration ; Drug mixture ; Female ; Hip arthroplasty ; Human ; Major clinical study ; Male ; Outcome assessment ; Pain assessment ; Pain intensity ; Periarticular drug administration ; Postoperative pain ; Postoperative period ; Priority journal ; Rating scale ; Soft tissue drug administration ; Unspecified side effect ; Verbal analog scale ; Visual analog scale ; Analgesia ; Combination drug therapy ; Drug effect ; Hip replacement ; Intraarticular drug administration ; Middle aged ; Pain measurement ; Postoperative pain ; Postoperative period ; Procedures ; Register ; Treatment outcome ; Very elderly ; Adult ; Aged ; Aged, 80 and over ; Analgesics ; Anesthetics ; Anti-inflammatory agents ; Arthroplasty ; Bupivacaine ; Cohort studies ; Drug therapy ; Female ; Humans ; Injections ; Ketorolac ; Male ; Middle aged ; Pain management ; Pain measurement ; Pain ; Postoperative period ; Registries ; Treatment outcome ; Hip arthroplasty ; Hip replacement ; Local anaesthesia ; Pain ; Pain management ; Post-operative ;
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